WO1997037026A1 - Novel compounds - Google Patents

Abstract

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Description

NOVEL COMPOUNDS yirid of the Invention;

This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy. Preferred embodiments of the invention include Streptococcal polypeptides and polynucleotides, particularly those of Streptococcus pneumoniae. Background of the Invention;

The Streptococci make up a medically important genera of microbes known to cause several types of disease in humans, including otitis media, pneumonia and meningitis. Since its isolation more than 100 years ago, Streptococcus pneumoniae has been one of the more intensively studied microbes. For example, much of our early understanding that DNA is, in fact, the genetic material was predicated on the work of Griffith and of Avery, Macleod and McCarty using this microbe. Despite the vast amount of research with S. pneumoniae, many questions concerning the virulence of this microbe remain.

While certain Streptococcal factors associated with pathogenicity have been identified, e.g., capsule polysaccharides, peptidoglycans, pneumolysins, PspA Complement factor H binding component, autolysin, neuraminidase, peptide permeases, hydrogen peroxide, IgAl protease, the list is certainly not complete. Further very little is known concerning the temporal expression of such genes during infection and disease progression in a mammalian host. Discovering the sets of genes the bacterium is likely to be expressing at the different stages of infection, particularly when an infection is established, provides critical information for the screening and characterization of novel antibacterials which can interrupt pathogenesis. In addition to providing a fuller understanding of known proteins, such an approach will identify previously unrecognised targets. Brief Description of the Invention;

This invention provides novel proteins, particularly those from Streptococcus pneumoniae, strain 0100993, characterised in that it comprises the amino acid sequences given herein or fragments, analogues or derivatives thereof.

In accordance with another aspect of the present invention, there are provided polynucleotides (DNA or RNA) which encode such polypeptides. In particular the invention provides polynucleotides having the DNA sequences given herein.

The invention also relates to novel oligonucleotides derived from the sequences given herein which can act as PCR primers in the process herein described to determine whether or not the Streptococcus pneumoniae gene identified herein in whole or in part is expressed in infected tissue. It is recognised that such sequences will also have utility in diagnosis of the stage of infection and type of infection the pathogen has attained. The proteins so identified are also useful as targets in screens designed to identify antimicrobial compounds. It is an object of the invention to provide polypeptides that have been identified as novel polypeptides by homology between the amino acid sequence set out in the Sequence Listing and a known amino acid sequence or sequences of other proteins such as the proteins identified under the heading Identity in Table 1.

It is a further object of the invention to provide polynucleotides that encode polypeptides set forth in the Sequence Listing, particularly polynucleotides that encode the polypeptide set forth in the Sequence Listing.

In a particularly preferred embodiment of the invention the polynucleotide comprises a region encoding polypeptides comprising the sequence set out in the Sequence Listing, or a variant thereof. In another particularly preferred embodiment of the invention there is a novel protein from comprising an amino acid sequence of the Sequence Listing, or a variant thereof.

In accordance with another aspect of the invention, there is provided the use of a polynucleotide of the invention for therapeutic or prophylactic purposes, in particular genetic immunization. Among the particularly preferred embodiments of the invention are naturally occurring allelic variants the polynucleotides set forth in the Sequence Listing and polypeptides encoded thereby.

In accordance with yet another aspect of the invention, there are provided inhibitors to such polypeptides, useful as antibacterial agents, including, for example, antibodies. In accordance with certain preferred embodiments of the invention, there are provided products, compositions and methods for assessing expression of the sequences the Sequence Listing, treating disease, for example, otitis media, conjunctivitis, pneumonia, bacteremia, meningitis, sinusitis, pleural empyema and endocarditis, and most particularly meningitis, such as for example infection of cerebrospinal fluid, assaying genetic variation, and administering a polypeptide or polynucleotide of the invention to an organism to raise an immunological response against a bacteria, especially a Streptococcus pneumoniae bacteria.

In accordance with certain preferred embodiments of this and other aspects of the invention there are provided polynucleotides that hybridize to polynucleotide sequences of the invention, particularly under stringent conditions.

In certain preferred embodiments of the invention there are provided antibodies against polypeptides of the invention.

In other embodiments of the invention there are provided methods for identifying compounds which bind to or otherwise interact with and inhibit or activate an activity of a polypeptide or polynucleotide of the invention comprising: contacting a polypeptide or polynucleotide of the invention with a compound to be screened under conditions to permit binding to or other interaction between the compound and the polypeptide or polynucleotide to assess the binding to or other interaction with the compound, such binding or interaction being associated with a second component capable of providing a detectable signal in response to the binding or interaction of the polypeptide or polynucleotide with the compound; and determining whether the compound binds to or otherwise interacts with and activates or inhibits an activity of the polypetide or polynucleotide by detecting the presence or absence of a signal generated from the binding or interaction ofthe compound with the polypeptide or polynucleotide.

In accordance with yet another aspect of the invention, there are provided agonists and antagonists of the polynucleotide and/or polypeptides of the invention, preferably bacteriostatic or bacteriocidal agonists and antagonists.

In a further aspect of the invention there are provided compositions comprising a polynucleotide or a polypeptide of the invention for administration to a cell or to a multicellular organism. Various changes and modifications within the spirit and scope of the disclosed invention will become readily apparent to those skilled in the art from reading the following descriptions and from reading the other parts of the present disclosure. Detailed Description of the Invention;

Each of the DNA sequences provided herein may be used in the discovery and development of antibacterial compounds. Because each of the sequences contains an open reading frame (ORF) with appropriate initiation and termination codons, the encoded protein upon expression can be used as a target for the screening of antimicrobial drugs. Additionally, the DNA sequences encoding preferably the amino terminal regions of the encoded protein or the Shine-Delgarno region can be used to construct antisense sequences to control the expression of the coding sequence of interest. Furthermore, many of the sequences disclosed herein also provide regions upstream and downstream from the encoding sequence. These sequences are useful as a source of regulatory elements for the control of bacterial gene expression. Such sequences are conveniently isolated by restriction enzyme action or synthesized chemically and introduced, for example, into promoter identification strains. These strains contain a reporter structural gene sequence located downstream from a restriction site such that if an active promoter is inserted, the reporter gene will be expressed.

Although each of the sequences may be employed as described above, this invention also provides several means for identifying particularly useful target genes. The first of these approaches entails searching appropriate databases for sequence matches in related organisms. Thus, if a homologue exists, the Streptococcal-like form of this gene would likely play an analogous role. For example, a Streptococcal protein identified as homologous to a cell surface protein in another organism would be useful as a vaccine candidate. To the extent such homologies have been identified for the sequences disclosed herein they are reported along with the encoding sequence.

Recently techniques have become available to evaluate temporal gene expression in bacteria, particularly as it applies to viability under laboratory and infection conditions. A number of methods can be used to identify genes which are essential to survival per se, or essential to the establishment/maintenance of an infection. Identification of an ORF unknown by one of these methods yields additional information about its function and permits the selection of such an ORF for further development as a screening target. Briefly, these approaches include: 1) Signature Tagged Mutagenesis (STM) This technique is described by Hensel el al, Science 269: 400-403( 1995), the contents of which is incoφorated by reference for background purposes. Signature tagged mutagenesis identifies genes necessary for the establishment/maintenance of infection in a given infection model.

The basis of the technique is the random mutagenesis of target organism by various means (e.g., transposons) such that unique DNA sequence tags are inserted in close proximity to the site of mutation. The tags from a mixed population of bacterial mutants and bacteria recovered from an infected hosts are detected by amplification, radiolabeling and hybridisation analysis. Mutants attenuated in virulence are revealed by absence of the tag from the pool of bacteria recovered from infected hosts. In Streptococcus pneumoniae. because the transposon system is less well developed, a more efficient way of creating the tagged mutants is to use the insertion - duplication mutagenesis technique as described by Morrison et al.. J. Bacteriol. 159:870 (1984) the contents of which is incorporated by reference for background purposes. 2) In Vivo Expression Technology (IVET)

This technique is described by Camilli el a]., Proc. Nat'l. Acad. Sci. USA. 91 :2634- 2638 (1994), the contents of which is incoφorated by reference for background puφoses. IVET identifies genes up-regulated during infection when compared to laboratory cultivation, implying an important role in infection. ORF identified by this technique are implied to have a significant role in infection establishment/maintenance.

In this technique random chromosomal fragments of target organism are cloned upstream of a promoter-less recombinase gene in a plasmid vector. This construct is introduced into the target organism which carries an antibiotic resistance gene flanked by. resolvase sites. Growth in the presence of the antibiotic removes from the population those fragments cloned into the plasmid vector capable of supporting transcription of the recombinase gene and therefore have caused loss of antibiotic resistance. The resistant pool is introduced into a host and at various times after infection bacteria may be recovered and assessed for the presence of antibiotic resistance. The chromosomal fragment carried by each antibiotic sensitive bacterium should carry a promoter or portion of a gene normally upregulated during infection. Sequencing upstream of the recombinase gene allows identification of the up regulated gene. 3) Differential display

This technique is described by Chuang el al-, J. Bacteriol. 175:2026-2036 (1993), the contents of which is incoφorated by reference for background puφoses. This method identifies those genes which are expressed in an organism by identifying mRNA present using randomly-primed RT-PCR. By comparing pre-infection and post infection profiles, genes up and down regulated during infection can be identified and the RT-PCR product sequenced and matched to ORF 'unknowns'. 4) Generation of conditional lethal mutants by transposon mutagenesis.

This technique, described by de Lorenzo, V. el al-. Gene 123: 17-24 (1993); Neuwald, A. F. el al, Gene 125: 69-73(1993); and Takiff, H. E. et al, J. Bacteriol. 174:1544-1553(1992), the contents of which is incoφorated by reference for background puφoses, identifies genes whose expression are essential for cell viability. In this technique transposons carrying controllable promoters, which provide transcription outward from the transposon in one or both directions, are generated. Random insertion of these transposons into target organisms and subsequent isolation of insertion mutants in the presence of inducer of promoter activity ensures that insertions which separate promoter from coding region of a gene whose expression is essential for cell viability will be recovered. Subsequent replica plating in the absence of inducer identifies such insertions, since they fail to survive. Sequencing of the flanking regions of the transposon allows identification of site of insertion and identification of the gene disrupted. Close monitoring of the changes in cellular processes/moφhology during growth in the absence of inducer yields information on likely function of the gene. Such monitoring could include flow cytometry (cell division, lysis, redox potential, DNA replication), incoφoration of radiochemically labeled precursors into DNA, RNA, protein, lipid, peptidoglycan, monitoring reporter enzyme gene fusions which respond to known cellular stresses. 5) Generation of conditional lethal mutants by chemical mutagenesis.

This technique is described by Beckwith, J.. Methods in Enzymology 204: 3-18(1991), the contents of which are incoφorated herein by reference for background puφoses. In this technique random chemical mutagenesis of target organism, growth at temperature other than physiological temperature (permissive temperature) and subsequent replica plating and growth at different temperature (e.g. 42°C to identify ts, 25"C to identify cs) are used to identify those isolates which now fail to grow (conditional mutants). As above close monitoring of the changes upon growth at the non-permissive temperature yields information on the function of the mutated gene. Complementation of conditional lethal mutation by library from target organism and sequencing of complementing gene allows matching with unknown ORF. 6) RT-PCR Streptococcus pneumoniae messenger RNA is isolated from bacterial infected tissue e.g. 48 hour murine lung infections, and the amount of each mRNA species assessed by reverse transcription of the RNA sample primed with random hexanucleotides followed by PCR with gene specific primer pairs. The determination of the presence and amount of a particular mRNA species by quantification of the resultant PCR product provides information on the bacterial genes which are transcribed in the infected tissue. Analysis of gene transcription can be carried out at different times of infection to gain a detailed knowledge of gene regulation in bacterial pathogenesis allowing for a clearer understanding of which gene products represent targets for screens for novel antibacterials. Because of the gene specific nature of the PCR primers employed it should be understood that the bacterial mRNA preparation need not be free of mammalian RNA. This allows the investigator to carry out a simple and quick RNA preparation from infected tissue to obtain bacterial mRNA species which are very short lived in the bacterium (in the order of 2 minute halflives). Optimally the bacterial mRNA is prepared from infected murine lung tissue by mechanical disruption in the presence of TRIzole (GIBCO-BRL) for very short periods of time, subsequent processing according to the manufacturers of TRIzole reagent and DNAase treatment to remove contaminating DNA. Preferably the process is optimised by finding those conditions which give a maximum amount of S.pneumoniae 16S ribosomal RNA as detected by probing Northerns with a suitably labelled sequence specific oligonucleotide probe. Typically a 5' dye labelled primer is used in each PCR primer pair in a PCR reaction which is terminated optimally between 8 and 25 cycles. The PCR products are separated on 6% polyacrylamide gels with detection and quantification using GeneScanner (manufactured by ABI).

Each of these techniques may have advantages or disadvantage depending on the particular application. The skilled artisan would choose the approach that is the most relevant with the particular end use in mind. For example, some genes might be recognised as essential for infection but in reality are only necessary for the initiation of infection and so their products would represent relatively unattractive targets for antibacterials developed to cure established and chronic infections.

Use of the of these technologies when applied to the ORFs of the present invention enables identification of bacterial proteins expressed during infection, inhibitors of which would have utility in anti-bacterial therapy. Streptococcus pneumoniae, strain 0100993 has been deposited at the National

Collection of Industrial and Marine Bacteria Ltd. (NCIMB), Aberdeen, Scotland under NCIMB number 40794 on 11 April 1996, and a Streptococcus pneumoniae, strain 0100993 DNA library in E. coli was similarly deposited on 17 April 1996 under NCIMB number 40800. The nucleotide sequences disclosed herein can be obtained by synthetic chemical techniques known in the art or can be obtained from Streptococcus pneumoniae, strain 0100993by probing a DNA preparation with probes constructed from the particular sequences disclosed herein. Alternatively, oligonucleotides derived from a disclosed sequence can act as PCR primers in a process of PCR-based cloning of the sequence from a bacterial genomic source. It is recognised that such sequences will also have utility in diagnosis of the stage of infection and type of infection the pathogen has attained.

To obtain the polynucleotide encoding the protein using the DNA sequence given herein typically a library of clones of chromosomal DNA of Streptococcus pneumoniae, strain 0100993 in E. coli or some other suitable host is probed with a radiolabelled oligonucleotide, preferably a 17mer or longer, derived from the partial sequence. Clones carrying DNA identical to that of the probe can then be distinguished using high stringency washes. By sequencing the individual clones thus identified with sequencing primers designed from the original sequence it is then possible to extend the sequence in both directions to determine the full gene sequence. Conveniently such sequencing is performed using denatured double stranded DNA prepared from a plasmid clone. Suitable techniques are described by Maniatis, T., Fritsch, E.F. and Sambrook, J. in MOLECULAR CLONING, A Laboratory Manual, 2nd edition, 1989, Cold Spring Harbor Laboratory (see: Screening By Hybridization 1.90 and Sequencing Denatured Double-Stranded DNA Templates 13.70).

A polynucleotide of the present invention may be in the form of RNA or in the form of DNA, which DNA includes cDNA, genomic DNA, and synthetic DNA. The DNA may be double-stranded or single-stranded, and if single stranded may be the coding strand or non-coding (anti-sense) strand. The coding sequence which encodes the polypeptide may be identical to the coding sequence shown or may be a different coding sequence which coding sequence, as a result of the redundancy or degeneracy of the genetic code, encoding the same polypeptide.

The present invention includes variants of the hereinabove described polynucleotides which encode fragments, analogues and derivatives of the polypeptide characterized by the deduced amino acid sequence given herein. The variant of the polynucleotide may be a naturally occurring allelic variant of the polynucleotide or a non- naturally occurring variant of the polynucleotide. In addition to the standard A, G, C, T U representations for nucleic acid bases, the term "N" is also used. "N" means that any of the four DNA or RNA bases may appear at such a designated position in the DNA or RNA sequence, except that N cannot be a base that when taken in combination with adjacent nucleotide positions, when read in the correct reading frame, would have the effect of generating a premature termination codon in such reading frame.

Thus, the present invention includes polynucleotides encoding the same polypeptide characterized by the deduced amino acid sequence given herein as well as variants of such polynucleotides which variants encode for a fragment, derivative or analogue of the polypeptide. Such nucleotide variants include deletion variants, substitution variants and addition or insertion variants.

The polynucleotide may have a coding sequence which is a naturally occurring allelic variant of the coding sequence characterized by the DNA sequence disclosed herein. As known in the art, an allelic variant is an altemate form of a polynucleotide sequence which may have a substitution, deletion or addition of one or more nucleotides, which does not substantially alter the function of the encoded polypeptide.

The polynucleotide which encodes for the mature polypeptide, may include only the coding sequence for the mature polypeptide or the coding sequence for the mature polypeptide and additional coding sequence such as a leader or secretory sequence or a proprotein sequence.

Thus, the term "polynucleotide encoding a polypeptide" encompasses a polynucleotide which includes only coding sequence for the polypeptide as well as a polynucleotide which includes additional coding and/or non-coding sequence.

The present invention therefore includes polynucleotides, wherein the coding sequence for the mature polypeptide may be fused in the same reading frame to a polynucleotide sequence which aids in expression and secretion of a polypeptide from a host cell, for example, a leader sequence which functions as a secretory sequence for controlling transport of a polypeptide from the cell. The polypeptide having a leader sequence is a preprotein and may have the leader sequence cleaved by the host cell to form the mature form of the polypeptide. The polynucleotides may also encode for a proprotein which is the mature protein plus additional 5' amino acid residues. A mature protein having a prosequence is a proprotein and may be an inactive form of the protein. Once the prosequence is cleaved an active mature protein remains.

Thus, for example, the polynucleotide of the present invention may code for a mature protein, or for a protein having a prosequence or for a protein having both a prosequence and a presequence (leader sequence). Further, the amino acid sequences provided herein show a methionine residue at the NH₂-terminus. It is appreciated, however, that during post-translational modification of the peptide, this residue may be deleted. Accordingly, this invention contemplates the use of both the methionine-containing and the methionineless amino terminal variants of each protein disclosed herein.

The polynucleotides of the present invention may also have the coding sequence fused in frame to a marker sequence at either the 5' or 3' terminus of the gene which allows for purification of the polypeptide of the present invention. The marker sequence may be a hexa-histidine tag supplied by the pQE series of vectors (supplied commercially by Quiagen Inc.) to provide for purification of the polypeptide fused to the marker in the case of a bacterial host. The present invention further relates to polynucleotides which hybridize to the hereinabove-described sequences if there is at least 50% and preferably at least 70% identity between the sequences. The present invention particularly relates to polynucleotides, particularly Streptococcal polynucleotides, which hybridize under stringent conditions to the hereinabove-described polynucleotides . As herein used, the term "stringent conditions" means hybridization will occur only if there is at least 95% and preferably at least 97% identity between the sequences. The polynucleotides which hybridize to the hereinabove described polynucleotides in a preferred embodiment encode polypeptides which retain substantially the same biological function or activity as the polypeptide characterised by the deduced amino acid sequence given herein. An example of stringent hybridization conditions is overnight incubation at 42°C in a solution comprising: 50% formamide, 5x SSC (150mM NaCl, 15mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5x Denhardt's solution, 10% dextran sulfate, and 20 micrograms/ml denatured, sheared salmon sperm DNA, followed by washing the hybridization support in 0.1 x SSC at about 65°C. Hybridization and wash conditions are well known and exemplified in Sambrook, et al., Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor, N.Y., (1989), particularly Chapter 11 therein.

The invention also provides a polynucleotide consisting essentially of a polynucleotide sequence obtainable by screening an appropriate library containing the complete gene for a polynucleotide sequence selected from the group consisting of the polynucleotides of the Sequence Listing under stringent hybridization conditions with a probe having the sequence of said polynucleotide sequence set forth in said polynucleotide of the Sequence Listing or a fragment thereof; and isolating said DNA sequence. Fragments useful for obtaining such a polynucleotide include, for example, probes and primers described elsewhere herein. "Identity," as known in the art and used herein, is a relationship between two or more polypeptide sequences or two or more polynucleotide sequences, as determined by comparing the sequences. In the art, "identity" also means the degree of sequence relatedness between polypeptide or polynucleotide sequences, as the case may be, as determined by the match between strings of such sequences. "Identity" and "similarity" can be readily calculated by known methods, including but not limited to those described in (Computational Molecular Biology, Lesk, A.M., ed., Oxford University Press, New York, 1988; Biocomputing: Informatics and Genome Projects, Smith, D.W., ed., Academic Press, New York, 1993; Computer Analysis of Sequence Data, Part I, Griffin, A.M., and Griffin, H.G., eds., Humana Press, New Jersey, 1994; Sequence Analysis in Molecular Biology, von Heinje, G., Academic Press, 1987; and Sequence Analysis Primer, Gribskov, M. and Devereux, J., eds., M Stockton Press, New York, 1991; and Carillo, H., and Lipman, D., SIAM J. Applied Math., 48: 1073 (1988). Preferred methods to determine identity are designed to give the largest match between the sequences tested. Methods to determine identity and similarity are codified in publicly available computer programs. Preferred computer program methods to determine identity and similarity between two sequences include, but are not limited to, the GCG program package (Devereux, J., et al., Nucleic Acids Research 12(1): 387 (1984)), BLASTP, BLASTN, and FASTA (Atschul, S.F. et al., J. Molec. Biol. 215: 403-410 (1990). The BLAST X program is publicly available from NCBI and other sources (BLAST Manual, Altschul, S., et al, NCBI NLM NIH Bethesda, MD 20894; Altschul, S., et ai, J. Mol. Biol. 215: 403-410 (1990).

As an illustration, by a polynucleotide having a nucleotide sequence having at least, for example, 95% "identity" to a reference nucleotide sequence selected from the group consisting of the polynucleotide of the Sequence Listing is intended that the nucleotide sequence of the polynucleotide is identical to the reference sequence except that the polynucleotide sequence may include up to five point mutations per each 100 nucleotides of the reference nucleotide sequence. In other words, to obtain a polynucleotide having a nucleotide sequence at least 95% identical to a reference nucleotide sequence, up to 5% of the nucleotides in the reference sequence may be deleted or substituted with another nucleotide, or a number of nucleotides up to 5% of the total nucleotides in the reference sequence may be inserted into the reference sequence. These mutations of the reference sequence may occur at the 5 or 3 terminal positions of the reference nucleotide sequence or anywhere between those terminal positions, interspersed either individually among nucleotides in the reference sequence or in one or more contiguous groups within the reference sequence.

Similarly, by a polypeptide having an amino acid sequence having at least, for example, 95% identity to a reference amino acid sequence of selected from the group consisting of the amino acids of the Sequence Listing is intended that the amino acid sequence of the polypeptide is identical to the reference sequence except that the polypeptide sequence may include up to five amino acid alterations per each 100 amino acids of the reference amino acid. In other words, to obtain a polypeptide having an amino acid sequence at least 95% identical to a reference amino acid sequence, up to 5% of the amino acid residues in the reference sequence may be deleted or substituted with another amino acid, or a number of amino acids up to 5% of the total amino acid residues in the reference sequence may be inserted into the reference sequence. These alterations of the reference sequence may occur at the amino or carboxy terminal positions of the reference amino acid sequence or anywhere between those terminal positions, interspersed either individually among residues in the reference sequence or in one or more contiguous groups within the reference sequence.

The deposit referred to herein will be maintained under the terms of the Budapest Treaty on the International Recognition of the Deposit of Micro-organisms for puφoses of Patent Procedure. These deposits are provided merely as convenience to those of skill in the art and are not an admission that a deposit is required under 35 U.S.C. §112. The sequence of the polynucleotides contained in the deposited material, as well as the amino acid sequence of the polypeptides encoded thereby, are incoφorated herein by reference and are controlling in the event of any conflict with any description of sequences herein. A license may be required to make, use or sell the deposited material, and no such license is hereby granted.

The terms "fragment," "derivative" and "analogue" when referring to the polypeptide characterized by the deduced amino acid sequence herein, means a polypeptide which retains essentially the same biological function or activity as such polypeptide. Thus, an analogue includes a proprotein which can be activated by cleavage of the proprotein portion to produce an active mature polypeptide.

The polypeptide of the present invention may be a recombinant polypeptide, a natural polypeptide or a synthetic polypeptide, preferably a recombinant polypeptide. The fragment, derivative or analogue of the polypeptide characterized by the deduced amino acid sequence herein may be (i) one in which one or more of the amino acid residues are substituted with a conserved or non-conserved amino acid residue (preferably a conserved amino acid residue) and such substituted amino acid residue may or may not be one encoded by the genetic code, or (ii) one in which one or more of the amino acid residues includes a substituent group, or (iii) one in which the polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (for example, polyethylene glycol), or (iv) one in which the additional amino acids are fused to the polypeptide, such as a leader or secretory sequence or a sequence which is employed for purification of the polypeptide or a proprotein sequence. Such fragments, derivatives and analogues are deemed to be within the scope of those skilled in the art from the teachings herein.

The polypeptides and polynucleotides of the present invention are preferably provided in an isolated form, and preferably are purified to homogeneity. The term "isolated" means that the material is removed from its original environment (e.g., the natural environment if it is naturally occurring). For example, a naturally-occurring polynucleotide or polypeptide present in a living animal is not isolated, but the same polynucleotide or polypeptide, separated from some or all of the coexisting materials in the natural system, is isolated. Such polynucleotides could be part of a vector and or such polynucleotides or polypeptides could be part of a composition, and still be isolated in that such vector or composition is not part of its natural environment.

The present invention also relates to vectors which include polynucleotides of the present invention, host cells which are genetically engineered with vectors of the invention and the production of polypeptides of the invention by recombinant techniques. In accordance with yet a further aspect of the present invention, there is therefore provided a process for producing the polypeptide of the invention by recombinant techniques by expressing a polynucleotide encoding said polypeptide in a host and recovering the expressed product. Alternatively, the polypeptides of the invention can be synthetically produced by conventional peptide synthesizers. Host cells are genetically engineered (transduced or transformed or transfected) with the vectors of this invention which may be, for example, a cloning vector or an expression vector. The vector may be, for example, in the form of a plasmid, a cosmid, a phage, etc. The engineered host cells can be cultured in conventional nutrient media modified as appropriate for activating promoters, selecting transformants or amplifying the genes. The culture conditions, such as temperature, pH and the like, are those previously used with the host cell selected for expression, and will be apparent to the ordinarily skilled artisan.

Suitable expression vectors include chromosomal, nonchromosomal and synthetic DNA sequences, e.g., bacterial plasmids; phage DNA; baculovirus; yeast plasmids; vectors derived from combinations of plasmids and phage DNA. However, any other vector may be used as long as it is replicable and viable in the host.

The appropriate DNA sequence may be inserted into the vector by a variety of procedures. In general, the DNA sequence is inserted into an appropriate restriction endonuclease site(s) by procedures known in the art.

The DNA sequence in the expression vector is operatively linked to an appropriate expression control sequence(s) (promoter) to direct mRNA synthesis. As representative examples of such promoters, there may be mentioned: LTR or SV40 promoter, the E. coli. lac or trp, the phage lambda Pj_^ promoter and other promoters known to control expression of genes in eukaryotic or prokaryotic cells or their viruses. The expression vector also contains a ribosome binding site for translation initiation and a transcription terminator. The vector may also include appropriate sequences for amplifying expression.

In addition, the expression vectors preferably contain one or more selectable marker genes to provide a phenotypic trait for selection of transformed host cells such as dihydrofolate reductase or neomycin resistance for eukaryotic cell culture, or such as tetracycline or ampicillin resistance in E. coli.

The gene can be placed under the control of a promoter, ribosome binding site (for bacterial expression) and, optionally, an operator (collectively referred to herein as "control" elements), so that the DNA sequence encoding the desired protein is transcribed into RNA in the host cell transformed by a vector containing this expression construction. The coding sequence may or may not contain a signal peptide or leader sequence. The polypeptides of the present invention can be expressed using, for example, the E. coli tae promoter or the protein A gene (spa) promoter and signal sequence. Leader sequences can be removed by the bacterial host in post-translational processing. See, e.g., U.S. Patent Nos. 4,431,739; 4,425,437; 4,338,397. Promoter regions can be selected from any desired gene using CAT (chloramphenicol transferase) vectors or other vectors with selectable markers. Two appropriate vectors are PKK232-8 and PCM7. Particular named bacterial promoters include lad, lacZ, T3, T7, gpt, lambda PR, PL and tφ. Eukaryotic promoters include CMV immediate early, HSV thymidine kinase, early and late SV40, LTRs from retrovirus, and mouse metallothionein-I. Selection of the appropriate vector and promoter is well within the level of ordinary skill in the art.

In addition to control sequences, it may be desirable to add regulatory sequences which allow for regulation of the expression of the protein sequences relative to the growth of the host cell. Regulatory sequences are known to those of skill in the art, and examples include those which cause the expression of a gene to be turned on or off in response to a chemical or physical stimulus, including the presence of a regulatory compound. Other types of regulatory elements may also be present in the vector, for example, enhancer sequences. An expression vector is constructed so that the particular coding sequence is located in the vector with the appropriate regulatory sequences, the positioning and orientation of the coding sequence with respect to the control sequences being such that the coding sequence is transcribed under the "control" of the control sequences (i.e., RNA polymerase which binds to the DNA molecule at the control sequences transcribes the coding sequence). Modification of the coding sequences may be desirable to achieve this end. For example, in some cases it may be necessary to modify the sequence so that it may be attached to the control sequences with the appropriate orientation; i.e., to maintain the reading frame. The control sequences and other regulatory sequences may be ligated to the coding sequence prior to insertion into a vector, such as the cloning vectors described above. Alternatively, the coding sequence can be cloned directly into an expression vector which already contains the control sequences and an appropriate restriction site.

Generally, recombinant expression vectors will include origins of replication and selectable markers permitting transformation of the host cell, e.g., the ampicillin resistance gene of E. coli and S. cerevisiae TRP1 gene, and a promoter derived from a highly- expressed gene to direct transcription of a downstream structural sequence. The heterologous structural sequence is assembled in appropriate phase with translation initiation and termination sequences, and preferably, a leader sequence capable of directing secretion of translated protein into the periplasmic space or extracellular medium. Optionally, the heterologous sequence can encode a fusion protein including an N-terminal identification peptide imparting desired characteristics, e.g., stabilization or simplified purification of expressed recombinant product.

The vector containing the appropriate DNA sequence as hereinabove described, as well as an appropriate promoter or control sequence, may be employed to transform an appropriate host to permit the host to express the protein. More particularly, the present invention also includes recombinant constructs comprising one or more of the sequences as broadly described above. The constructs comprise a vector, such as a plasmid or viral vector, into which a sequence of the invention has been inserted, in a forward or reverse orientation. In a preferred aspect of this embodiment, the construct further comprises regulatory sequences, including, for example, a promoter, operably linked to the sequence. Large numbers of suitable vectors and promoters are known to those of skill in the art, and are commercially available. The following vectors are provided by way of example. Bacterial: pET-3 vectors (Stratagene), pQE70, pQE60, pQE-9 (Qiagen), pbs, pDIO, phagescript, psiX174, pbluescript SK, pbsks, pNH8A, pNH16a, pNH18A, pNH46A (Stratagene); ptrc99a, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia). Eukaryotic: pBlueBacIII (Invitrogen), pWLNEO, pSV2CAT, pOG44, pXTl, pSG (Stratagene) pSVK3, pBPV, pMSG, pSVL (Pharmacia). However, any other plasmid or vector may be used as long as they are replicable and viable in the host. Examples of recombinant DNA vectors for cloning and host cells which they can transform include the bacteriophage 1 (£. coli), pBR322 (E. coli), pACYC177 (E. coli), pKT230 (gram-negative bacteria), pGVl 106 (gram-negative bacteria), pLAFRl (gram- negative bacteria), pME290 (non-E coli gram-negative bacteria), pHV14 (E. coli and Bacillus subtilis), pBD9 (Bacillus), pIJ61 (Streptomyces), pUC6 (Streptomyces), YIp5 (Saccharomyces), a baculovirus insect cell system, YCpl9 (Saccharomyces). See, generally, "DNA Cloning": Vols. I & II, Glover et al. ed. IRL Press Oxford (1985) (1987) and; T. Maniatis et al. ("Molecular Cloning" Cold Spring Harbor Laboratory (1982).

In some cases, it may be desirable to add sequences which cause the secretion of the polypeptide from the host organism, with subsequent cleavage of the secretory signal. Polypeptides can be expressed in host cells under the control of appropriate promoters. Cell-free translation systems can also be employed to produce such proteins using RNAs derived from the DNA constructs of the present invention. Appropriate cloning and expression vectors for use with prokaryotic and eukaryotic hosts are described by Sambrook, et al.. Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor, N.Y., (1989), the disclosure of which is hereby incoφorated by reference. Following transformation of a suitable host strain and growth of the host strain to an appropriate cell density, the selected promoter is induced by appropriate means (e.g., temperature shift or chemical induction) and cells are cultured for an additional period. Cells are typically harvested by centrifugation, disrupted by physical or chemical means, and the resulting crude extract retained for further purification.

Microbial cells employed in expression of proteins can be disrupted by any convenient method, including freeze-thaw cycling, sonication, mechanical disruption, or use of cell lysing agents, such methods are well known to those skilled in the art.

Depending on the expression system and host selected, the polypeptide of the present invention may be produced by growing host cells transformed by an expression vector described above under conditions whereby the polypeptide of interest is expressed. The polypeptide is then isolated from the host cells and purified. If the expression system secretes the polypeptide into growth media, the polypeptide can be purified directly from the media. If the polypeptide is not secreted, it is isolated from cell lysates or recovered from the cell membrane fraction. Where the polypeptide is localized to the cell surface, whole cells or isolated membranes can be used as an assayable source of the desired gene product. Polypeptide expressed in bacterial hosts such as E. coli may require isolation from inclusion bodies and refolding. Where the mature protein has a very hydrophobic region which leads to an insoluble product of overexpression, it may be desirable to express a truncated protein in which the hydrophobic region has been deleted. The selection of the appropriate growth conditions and recovery methods are within the skill of the art.

The polypeptide can be recovered and purified from recombinant cell cultures by methods including ammonium sulphate or ethanol precipitation, acid extraction, anion or cation exchange chromatography, phosphocellulose chromatography, hydrophobic interaction chromatography, affinity chromatography, hydroxylapatite chromatography and lectin chromatography. Protein refolding steps can be used, as necessary, in completing configuration of the mature protein. Finally, high performance liquid chromatography (HPLC) can be employed for final purification steps.

Depending upon the host employed in a recombinant production procedure, the polypeptides of the present invention may be glycosylated or may be non-glycosylated. Polypeptides of the invention may also include an initial methionine amino acid residue.

A "replicon" is any genetic element (e.g., plasmid, chromosome, virus) that functions as an autonomous unit of DNA replication in vivo; i.e., capable of replication under its own control.

A "vector" is a replicon, such as a plasmid, phage, or cosmid, to which another DNA segment may be attached so as to bring about the replication of the attached segment. A "double-stranded DNA molecule" refers to the polymeric form of deoxyribonucleotides (bases adenine, guanine, thymine, or cytosine) in a double-stranded helix, both relaxed and supercoiled. This term refers only to the primary and secondary structure of the molecule, and does not limit it to any particular tertiary forms. Thus, this term includes double-stranded DNA found, inter alia, in linear DNA molecules (e.g., restriction fragments), viruses, plasmids, and chromosomes. In discussing the structure of particular double-stranded DNA molecules, sequences may be described herein according to the normal convention of giving only the sequence in the 5' to 3' direction along the nontranscribed strand of DNA (i.e., the strand having the sequence homologous to the mRNA).

A DNA "coding sequence of or a "nucleotide sequence encoding" a particular protein, is a DNA sequence which is transcribed and translated into a polypeptide when placed under the control of appropriate regulatory sequences.

A "promoter sequence" is a DNA regulatory region capable of binding RNA polymerase in a cell and initiating transcription of a downstream (3' direction) coding sequence. For puφoses of defining the present invention, the promoter sequence is bound at the 3' terminus by a translation start codon (e.g., ATG) of a coding sequence and extends upstream (5' direction) to include the minimum number of bases or elements necessary to initiate transcription at levels detectable above background. Within the promoter sequence will be found a transcription initiation site (conveniently defined by mapping with nuclease SI), as well as protein binding domains (consensus sequences) responsible for the binding of RNA polymerase. Eukaryotic promoters will often, but not always, contain "TATA" boxes and "CAT" boxes. Prokaryotic promoters contain Shine-Dalgarno sequences in addition to the -10 and -35 consensus sequences. DNA "control sequences" refers collectively to promoter sequences, ribosome binding sites, polyadenylation signals, transcription termination sequences, upstream regulatory domains, enhancers, and the like, which collectively provide for the expression (i.e., the transcription and translation) of a coding sequence in a host cell.

A control sequence "directs the expression" of a coding sequence in a cell when RNA polymerase will bind the promoter sequence and transcribe the coding sequence into mRNA, which is then translated into the polypeptide encoded by the coding sequence.

A "host cell" is a cell which has been transformed or transfected, or is capable of transformation or transfection by an exogenous DNA sequence. A cell has been "transformed" by exogenous DNA when such exogenous DNA has been introduced inside the cell membrane. Exogenous DNA may or may not be integrated (covalently linked) into chromosomal DNA making up the genome of the cell. In prokaryotes and yeasts, for example, the exogenous DNA may be maintained on an episomal element, such as a plasmid. With respect to eukaryotic cells, a stably transformed or transfected cell is one in which the exogenous DNA has become integrated into the chromosome so that it is inherited by daughter cells through chromosome replication. This stability is demonstrated by the ability of the eukaryotic cell to establish cell lines or clones comprised of a population of daughter cell containing the exogenous DNA. A "clone" is a population of cells derived from a single cell or common ancestor by mitosis. A "cell line" is a clone of a primary cell that is capable of stable growth in vitro for many generations.

A "heterologous" region of a DNA construct is an identifiable segment of DNA within or attached to another DNA molecule that is not found in association with the other molecule in nature.

This invention is also related to the use of the polynucleotides of the invention for use as diagnostic reagents. Detection of a polynucleotide or polypeptide of the invention in a eukaryote, particularly a mammal, and especially a human, will provide a diagnostic method for diagnosis of a disease. Eukaryotes (herein also "individual(s)"), particularly mammals, and especially humans, infected with an organism comprising a polynucleotide of the invention may be detected at the nucleic acid level by a variety of techniques.

Nucleic acids for diagnosis may be obtained from an infected individual's cells and tissues, such as bone, blood, muscle, cartilage, and skin. Genomic DNA may be used directly for detection or may be amplified enzymatically by using PCR or other amplification technique prior to analysis. RNA or cDNA may also be used in the same ways. Using amplification, characterization of the species and strain of prokaryote present in an individual, may be made by an analysis ofthe genotype ofthe prokaryote gene. Deletions and insertions can be detected by a change in size of the amplified product in comparison to the genotype of a reference sequence. Point mutations can be identified by hybridizing amplified DNA to labeled polynucleotide sequences of the invention. Perfectly matched sequences can be distinguished from mismatched duplexes by RNase digestion or by differences in melting temperatures. DNA sequence differences may also be detected by alterations in the electrophoretic mobility of the DNA fragments in gels, with or without denaturing agents, or by direct DNA sequencing. See, e.g., Myers et al., Science, 230: 1242 (1985). Sequence changes at specific locations also may be revealed by nuclease protection assays, such as RNase and SI protection or a chemical cleavage method. See, e.g., Cotton et al., Proc. Natl. Acad. Sci, USA, 85: 4397-4401

(1985).

Cells carrying mutations or polymoφhisms in the gene of the invention may also be detected at the DNA level by a variety of techniques, to allow for serotyping, for example. For example, RT-PCR can be used to detect mutations. It is particularly preferred to used RT-PCR in conjunction with automated detection systems, such as, for example, GeneScan. RNA or cDNA may also be used for the same purpose, PCR or RT-PCR. As an example, PCR primers complementary to a nucleic acid encoding a polypeptide of the invention can be used to identify and analyze mutations. These primers may be used for, among othe4r things, amplifying DNA isolated from a sample derived from an individual. The primers may be used to amplify the gene isolated from an infected individual such that the gene may then be subject to various techniques for elucidation of the DNA sequence. In this way, mutations in the DNA sequence may be detected and used to diagnose infection and to serotype and/or classify the infectious agent. The invention further provides a process for diagnosing, disease, preferably bacterial infections, more preferably infections by Streptococcus pneumoniae, comprising determining from a sample derived from an individual a increased level of expression of polynucleotide having a sequence set forth in the Sequence Listing or a sequence of the invention. Increased or decreased expression of a polynucleotide of the invention can be measured using any on of the methods well known in the art for the quantation of polynucleotides, such as, for example, amplification, PCR, RT-PCR, RNase protection, Northern blotting and other hybridization methods.

In addition, a diagnostic assay in accordance with the invention for detecting over¬ expression of a polypeptide of the invention compared to normal control tissue samples may be used to detect the presence of an infection, for example. Assay techniques that can be used to determine levels of a polypeptide of the invention, in a sample derived from a host are well- known to those of skill in the art. Such assay methods include radioimmunoassays, competitive- binding assays, Western Blot analysis and ELISA assays.

In accordance with yet a further aspect of the present invention, there is provided the use of a polypeptide of the invention for therapeutic or prophylactic puφoses, for example, as an antibacterial agent or a vaccine.

In accordance with another aspect of the present invention, there is provided the use of a polynucleotide of the invention for therapeutic or prophylactic puφoses, in particular genetic immunisation. In accordance with yet another aspect of the present invention, there are provided inhibitors to such polypeptides, useful as antibacterial agents. In particular, there are provided antibodies against such polypeptides.

Polypeptides of the invention may also be used to assess the binding of small molecule substrates and ligands in, for example, cells, cell-free preparations, chemical libraries, and natural product mixtures. These substrates and ligands may be natural substrates and ligands or may be structural or functional mimetics. See, e.g., Coligan et ai, Current Protocols in Immunology

1(2): Chapter 5 (1991).

The invention also provides a method of screening compounds to identify those which enhance (agonist) or block (antagonist) the action of polypeptides or polynucleotides of the invention, particularly those compounds that are bacteriostatic and/or bacteriocidal. The method of screening may involve high-throughput techniques. For example, to screen for agonists or antagoists, a synthetic reaction mix, a cellular compartment, such as a membrane, cell envelope or cell wall, or a preparation of any thereof, comprising a polypeptide of the invention and a labeled substrate or ligand of such polypeptide is incubated in the absence or the presence of a candidate molecule that may be an agonist or antagonist of a polypeptide of the invention. The ability of the candidate molecule to agonize or antagonize a polypeptide of the invention is reflected in decreased binding of the labeled ligand or decreased production of product from such substrate. Molecules that bind gratuitously, i.e., without inducing the effects of a polypeptide of the invention are most likely to be good antagonists. Molecules that bind well and increase the rate of product production from substrate are agonists. Detection ofthe rate or level of production of product from substrate may be enhanced by using a reporter system. Reporter systems that may be useful in this regard include but are not limited to colorimetric labeled substrate converted into product, a reporter gene that is responsive to changes in polynucleotide or polypeptide activity, and binding assays known in the art.

Another example of an assay for antagonists of a polypeptide of the invention is a competitive assay that combines such polypeptide and a potential antagonist with polypeptide- binding molecules, recombinant polypeptide-binding molecules, natural substrates or ligands, or substrate or ligand mimetics, under appropriate conditions for a competitive inhibition assay. Polypeptides of the invention can be labeled, such as by radioactivity or a colorimetric compound, such that the number of such polypeptide molecules bound to a binding molecule or converted to product can be deterrnined accurately to assess the effectiveness of the potential antagonist. Potential antagonists include small organic molecules, peptides, polypeptides and antibodies that bind to a polynucleotide or polypeptide of the invention and thereby inhibit or extinguish its activity. Potential antagonists also may be small organic molecules, a peptide, a polypeptide such as a closely related protein or antibody that binds the same sites on a binding molecule, without inducing an activities of a polypeptide of the invention, thereby preventing the action of such polypeptide by excluding it from binding.

Potential antagonists include a small molecule that binds to and occupies the binding site of the polypeptide thereby preventing binding to cellular binding molecules, such that normal biological activity is prevented. Examples of small molecules include but are not limited to small organic molecules, peptides or peptide-like molecules. Other potential antagonists include antisense molecules (see Okano, J. Neurochem. 56: 560 (1991); OUGODEOXYNUCLEOT1DES AS ANTISENSE INHIBITORS OF GENE EXPRESSION, CRC Press, Boca Raton, FL (1988), for a description of these molecules). Preferred potential antagonists include compounds related to and variants of the poiypetides of the invention. Each of the DNA sequences provided herein may be used in the discovery and development of antibacterial compounds. The encoded protein, upon expression, can be used as a target for the screening of antibacterial drugs. Additionally, the DNA sequences encoding the amino terminal regions of the encoded protein or Shine-Delgamo or other translation facilitating sequences of the respective mRNA can be used to construct antisense sequences to control the expression of the coding sequence of interest.

The invention also provides the use of the polypeptide, polynucleotide or inhibitor of the invention to interfere with the initial physical interaction between a pathogen and mammalian host responsible for sequelae of infection. In particular the molecules of the invention may be used: in the prevention of adhesion of bacteria, in particular gram positive bacteria, to mammalian extracellular matrix proteins on in-dwelling devices or to extracellular matrix proteins in wounds; to block protein-mediated mammalian cell invasion by, for example, initiating phosphorylation of mammalian tyrosine kinases (Rosenshine et al.. Infect. Immun. 60:221 1 (1992); to block bacterial adhesion between mammalian extracellular matrix proteins and bacterial proteins that mediate tissue damage and; to block the normal progression of pathogenesis in infections initiated other than by the implantation of in-dwelling devices or by other surgical techniques.

The antagonists and agonists of the invention may be employed, for instance, to inhibit and treat otitis media, conjunctivitis, pneumonia, bacteremia, meningitis, sinusitis, pleural empyema and endocarditis, and most particularly meningitis, such as for example infection of cerebrospinal fluid.

Another aspect of the invention is a pharmaceutical composition comprising the above polypeptide, polynucleotide or inhibitor of the invention and a pharmaceutically acceptable carrier.

In a particular aspect the invention provides the use of an inhibitor of the invention as an antibacterial agent.

The invention further relates to the manufacture of a medicament for such uses.

The polypeptide may be used as an antigen for vaccination of a host to produce specific antibodies which have anti-bacterial action. This invention also contemplates the use of the DNA encoding the antigen as a component in a DNA vaccine as discussed more fully below.

The polypeptides or cells expressing them can be used as an immunogen to produce antibodies thereto. These antibodies can be, for example, polyclonal or monoclonal antibodies. The term antibodies also includes chimeric, single chain, and humanized antibodies, as well as Fab fragments, or the product of an Fab expression library. Various procedures known in the art may be used for the production of such antibodies and fragments.

Antibodies generated against the polypeptides of the present invention can be obtained by direct injection of the polypeptides into an animal or by administering the polypeptides to an animal, preferably a nonhuman. The antibody so obtained will then bind the polypeptides itself. In this manner, even a sequence encoding only a fragment of the polypeptides can be used to generate antibodies binding the whole native polypeptides. Such antibodies can then be used to isolate the polypeptide from tissue expressing that polypeptide.

Polypeptide derivatives include antigenically or immunologically equivalent derivatives which form a particular aspect of this invention.

The term 'antigenically equivalent derivative' as used herein encompasses a polypeptide or its equivalent which will be specifically recognised by certain antibodies which, when raised to the protein or polypeptide according to the present invention, interfere with the interaction between pathogen and mammalian host.

The term 'immunologically equivalent derivative' as used herein encompasses a peptide or its equivalent which when used in a suitable formulation to raise antibodies in a vertebrate, the antibodies act to interfere with the interaction between pathogen and mammalian host.

In particular derivatives which are slightly longer or slightly shorter than the native protein or polypeptide fragment of the present invention may be used. In addition, polypeptides in which one or more of the amino acid residues are modified may be used. Such peptides may, for example, be prepared by substitution, addition, or rearrangement of amino acids or by chemical modification thereof. All such substitutions and modifications are generally well known to those skilled in the art of peptide chemistry.

The polypeptide, such as an antigenically or immunologically equivalent derivative or a fusion protein thereof is used as an antigen to immunize a mouse or other animal such as a rat or chicken. The fusion protein may provide stability to the polypeptide. The antigen may be associated, for example by conjugation , with an immunogenic carrier protein for example bovine serum albumin (BSA) or keyhole limpet haemocyanin (KLH). Alternatively a multiple antigenic peptide comprising multiple copies of the protein or polypeptide, or an antigenically or immunologically equivalent polypeptide thereof may be sufficiently antigenic to improve immunogenicity so as to obviate the use of a carrier.

For preparation of monoclonal antibodies, any technique which provides antibodies produced by continuous cell line cultures can be used. Examples include the hybridoma technique (Kohler and Milstein, Nature. 256:495-497(1975)), the trioma technique, the human B-cell hybridoma technique (Kozbor et al., Immunology Today 4:72(1983)), and the EBV-hybridoma technique to produce human monoclonal antibodies (Cole, et al., 1985, in Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., pp. 77-96).

Techniques described for the production of single chain antibodies (U.S. Patent 4,946,778) can be adapted to produce single chain antibodies to immunogenic polypeptide products of this invention.

Using the procedure of Kohler and Milstein (supra. (1975)), antibody-containing cells from the immunised mammal are fused with myeloma cells to create hybridoma cells secreting monoclonal antibodies.

The hybridomas are screened to select a cell line with high binding affinity and favorable cross reaction with other Streptococcal species using one or more of the original polypeptide and/or the fusion protein. The selected cell line is cultured to obtain the desired Mab.

Hybridoma cell lines secreting the monoclonal antibody are another aspect of this invention. Alternatively phage display technology could be utilised to select antibody genes with binding activities towards the polypeptide either from repertoires of PCR amplified v- genes of lymphocytes from humans screened for possessing anti-Fbp or from naive libraries (McCafferty, J. et al, Nature 348:552-554(1990), and Marks, J. et al, Biotechnology 10:779-783(1992)). The affinity of these antibodies can also be improved by chain shuffling (Clackson, T. et al, Nature 352:624-628(1991)).

The antibody should be screened again for high affinity to the polypeptide and/or fusion protein.

As mentioned above, a fragment of the final antibody may be prepared. The antibody may be either intact antibody of M_r approx 150,000 or a derivative of it, for example a Fab fragment or a Fv fragment as described in Skerra, A and Pluckthun, A., Science 240: 1038-1040 (1988). If two antigen binding domains are present each domain may be directed against a different epitope - termed 'bispecific' antibodies.

The antibody of the invention may be prepared by conventional means for example by established monoclonal antibody technology (Kohler, G. and Milstein, C. (supra. (1975) or using recombinant means e.g. combinatorial libraries, for example as described in Huse, W.D. _-/ α/., S_cie_Q£e 246:1275-1281 (1989).

Preferably the antibody is prepared by expression of a DNA polymer encoding said antibody in an appropriate expression system such as described above for the expression of polypeptides of the invention. The choice of vector for the expression system will be determined in part by the host, which may be a prokaryotic cell, such as E. coli (preferably strain B) or Streptomyces sp. or a eukaryotic cell, such as a mouse C127, mouse myeloma, human HeLa, Chinese hamster ovary, filamentous or unicellular fungi or insect cell. The host may also be a transgenic animal or a transgenic plant (for example, as described in Hiatt, A. et al, Nature 340:76-78(1989). Suitable vectors include plasmids, bacteriophages, cosmids and recombinant viruses, derived from, for example, baculoviruses and vaccinia.

The Fab fragment may also be prepared from its parent monoclonal antibody by enzyme treatment, for example using papain to cleave the Fab portion from the Fc portion.

Preferably the antibody or derivative thereof is modified to make it less immunogenic in the patient. For example, if the patient is human the antibody may most preferably be 'humanised'; where the complimentarity determining region(s) of the hybridoma-derived antibody has been transplanted into a human monoclonal antibody , for example as described in Jones, P. et al, Nature 321 :522-525 (1986), or Tempest et al., Biotechnology 9:266-273 (1991). The modification need not be restricted to one of 'humanisation' ; other primate sequences (for example Newman, R. et al. Biotechnology 10:1455-1460 (1992)) may also be used.

The humanised monoclonal antibody, or its fragment having binding activity, form a particular aspect of this invention.

This invention provides a method of screening drugs to identify those which interfere with the proteins selected as targets herein, which method comprises measuring the interference of the activity of the protein by a test drug. For example if the protein selected has a catalytic activity, after suitable purification and formulation the activity of the enzyme can be followed by its ability to convert its natural substrates. By incoφorating different chemically synthesised test compounds or natural products into such an assay of enzymatic activity one is able to detect those additives which compete with the natural substrate or otherwise inhibit enzymatic activity.

The invention also relates to inhibitors identified thereby. The use of a polynucleotide of the invention in genetic immunisation will preferably employ a suitable delivery method such as direct injection of plasmid DNA into muscles (Wolff et al., Hum. Mol. Genet. 1:363 (1992); Manthoφe et al.. Hum. Gene Ther. 4:419 (1963)), delivery of DNA complexed with specific protein carriers ( Wu et al, _ Biol. Chem. 264: 16985 (1989)), coprecipitation of DNA with calcium phosphate (Benvenisty & Reshef, Proc. Nat'l Acad. Sci. USA. 83:9551 (1986)), encapsulation of DNA in various forms of liposomes (Kaneda et al, Science 243:375 (1989)), particle bombardment (Tang et al, Nature 356:152 (1992)); Eisenbraun et al, DNA Cell Biol. 12:791 ( 1993)) and in vivo infection using cloned retroviral vectors (Seeger et al, Proc. Nat'l. Acad. Sci. USA 81 :5849 (1984)). Suitable promoters for muscle transfection include CMV, RSV, SRa, actin, MCK, alpha globin, adenovirus and dihydrofolate reductase.

In therapy or as a prophylactic, the active agent i.e., the polypeptide, polynucleotide or inhibitor of the invention, may be administered to a patient as an injectable composition, for example as a sterile aqueous dispersion, preferably isotonic.

Alternatively the composition may be formulated for topical application for example in the form of ointments, creams, lotions, eye ointments, eye drops, ear drops, mouthwash, impregnated dressings and sutures and aerosols, and may contain appropriate conventional additives, including, for example, preservatives, solvents to assist drug penetration, and emollients in ointments and creams. Such topical formulations may also contain compatible conventional carriers, for example cream or ointment bases, and ethanol or oleyl alcohol for lotions. Such carriers may constitute from about 1 % to about 98% by weight of the formulation; more usually they will constitute up to about 80% by weight of the formulation.

For administration to human patients, it is expected that the daily dosage level of the active agent will be from 0.01 to 10 mg/kg, typically around 1 mg kg. The physician in any event will determine the actual dosage which will be most suitable for an individual patient and will vary with the age, weight and response of the particular patient. The above dosages are exemplary of the average case. There can, of course, be individual instances where higher or lower dosage ranges are merited, and such are within the scope of this invention.

A vaccine composition is conveniently in injectable form. Conventional adjuvants may be employed to enhance the immune response.

A suitable unit dose for vaccination is 0.5-5 μg/kg of antigen, and such dose is preferably administered 1-3 times and with an interval of 1-3 weeks. Within the indicated dosage range, no adverse toxicologicals effects are expected with the compounds of the invention which would preclude their administration to suitable patients.

In order to facilitate understanding of the following example certain frequently occurring methods and/or terms will be described. "Plasmids" are designated by a lower case p preceded and/or followed by capital letters and/or numbers. The starting plasmids herein are either commercially available, publicly available on an unrestricted basis, or can be constructed from available plasmids in accord with published procedures. In addition, equivalent plasmids to those described are known in the art and will be apparent to the ordinarily skilled artisan. "Digestion" of DNA refers to catalytic cleavage of the DNA with a restriction enzyme that acts only at certain sequences in the DNA. The various restriction enzymes used herein are commercially available and their reaction conditions, cofactors and other requirements were used as would be known to the ordinarily skilled artisan. For analytical puφoses, typically 1 μg of plasmid or DNA fragment is used with about 2 units of enzyme in about 20 μl of buffer solution. For the puφose of isolating DNA fragments for plasmid construction, typically 5 to 50 μg of DNA are digested with 20 to 250 units of enzyme in a larger volume. Appropriate buffers and substrate amounts for particular restriction enzymes are specified by the manufacturer. Incubation times of about 1 hour at 37° C are ordinarily used, but may vary in accordance with the supplier's instructions. After digestion the reaction is electrophoresed directly on a polyacrylamide gel to isolate the desired fragment.

Size separation of the cleaved fragments is performed using 8 percent polyacrylamide gel described by Goeddel, D. et al, (1980) Nucleic Acids Res., 8:4057. "Oligonucleotides" refers to either a single stranded polydeoxynucleotide or two complementary polydeoxynucleotide strands which may be chemically synthesized. Such synthetic oligonucleotides have no 5' phosphate and thus will not ligate to another oligonucleotide without adding a phosphate with an ATP in the presence of a kinase. A synthetic oligonucleotide will ligate to a fragment that has not been dephosphorylated. "Ligation" refers to the process of forming phosphodiester bonds between two double stranded nucleic acid fragments (Maniatis, T., et al., supra.. p. 146). Unless otherwise provided, ligation may be accomplished using known buffers and conditions with 10 units to T4 DNA ligase ("ligase") per 0.5 μg of approximately equimolar amounts of the DNA fragments to be ligated. Example 1

Isolation of DNA coding for a virulence gene in Streptococcus pneumoniae

As mentioned above each of the DNAs disclosed herein by virtue of the fact that it includes an intact open reading frame is useful to a greater or lesser extent as a screen for identifying antimicrobial compounds. A useful approach for selecting the preferred DNA sequences for screen development is evaluation by insertion-duplication mutagenesis. This system disclosed by Morrison et al., J. Bacteriol. 159:870 (1984), is applied as follows.

Briefly, random fragments of Streptococcus pneumoniae, strain 0100993 DNA are generated enzymatically (by restriction endonuclease digestion) or physically (by sonication based shearing) followed by gel fractionation and end repair employing T4 DNA polymerase. It is preferred that the DNA fragments so produced are in the range of 200-400 base pairs, a size sufficient to ensure homologous recombination and to insure a representative library in E.coli. The fragments are then inserted into appropriately tagged plasmids as described in Hensel el al-, Science 269: 400-403(1995). Although a number of plasmids can be used for this puφose, a particularly useful plasmid is pJDC9 described by Pearce et al., Mol. Microbiol. 9:1037 (1993) which carries the erm gene facilitating erythromycin selection in either E. coli or S. pneumoniae previously modified by incoφoration of DNA sequence tags into one of the polylinker cloning sites. The tagged plasmids are introduced into the appropriate 5. pneumoniae strain selected, inter alia, on the basis of serotype and virulence in a murine model of pneumococcal pneumonia. It is appreciated that a seventeen amino acid competence factor exists (Havastein et al., Proc. Nat'l. Acad. Sci. USA 92:11140-44 (1995)) and may be usefully employed in this protocol to increase the transformation frequencies. A proportion of transformants are analysed to verify homologous integration and as a check on stability. Unwanted levels of reversion are minimized because the duplicated regions will be short (200-400 bp), however if significant reversion rates are encountered they may be modulated by maintaining antibiotic selection during the growth ofthe transformants in culture and/or during growth in the animal.

The S. pneumoniae transformants are pooled for inoculation into mice, eg., Swiss and/or C57B1/6. Preliminary experiments are conducted to establish the optimum complexity of the pools and level of inoculum. A particularly useful model has been described by Veber et al. (J. Antimicrobiol. Chemother.32:432 (1993) in which 10^ cfu inocula sizes are introduced by mouth to the trachea. Strain differences are observed with respect to onset of disease e.g. ,3-4 days for Swiss mice and 8-10 days for C57B1/6. Infection yields in the lungs approach 10° cfu/lung. IP administration is also possible when genes mediating blood stream infection are evaluated. Following optimization of parameters of the infection model, the mutant bank normally comprising several thousand strains is subjected to the virulence test. Mutants with attenuated virulence are identified by hybridization analysis using the labelled tags from the "input" and "recovered" pools as probes as described in Hensel el al, Science 269: 400-403(1995). S. pneumoniae DNA is colony blotted or dot blotted, DNA flanking the integrated plasmid is cloned by plasmid rescue in E. coli (Morrison et al., J. Bacteriol. 159:870 (1984)) and sequenced. Following sequencing, the DNA is compared to the nucleotide sequences given herein and the appropriate ORF is identified and function confirmed for example by knock-out studies. Expression vectors providing the selected protein are prepared and the protein is configured in an appropriate screen for the identification of anti-microbial agents. Alternatively, genomic DNA libraries are probed with restriction fragments flanking the integrated plasmid to isolate full-length cloned virulence genes whose function can be confirmed by "knock-out" studies or other methods, which are then expressed and incoφorated into a screen as described above.

The individual full length sequences given herein are summarized in the following Tables (Table 1 and Table 2). Under the column in Table 1 labeled "Identity" there is the deduced identity of each open reading frame of the invention determined using Blastp and/or MPSearch. The ORF# column indicates whether the polynucleotide encoding each ORF encodes more than one ORF. For example, SEQ ID NO:224 has an ORF# 1 but no #2; thus the polynucleotide encodes this ORF#l, but no other ORF was detected. On the other hand, SEQ ID NO:225 and 226 have ORF#s 1 and 2 respectively, indicating that they were both encoded by the same polynucleotide. This can also be seen in Table 2 where the polynucleotide of SEQ ID NO: 2 encodes the ORFs of SEQ ID NOS: 225 and 226. Table 1 also shows the start ("START" column) and stop ("STOP" column) codons for each ORF and their positions in the encoding polynucleotide sequence. The SEQ ID NOS of the polypeptides of this table are linked to both a deduced identity in this table and a polynucleotide sequence in Table 2 which encodes each polypeptide. The "Direction" column in Table 1 shows the direction of the ORF encoding each poypetide in this table. "Forward" denotes the sense orientation and "Reverse" denotes the antisense orientation of the ORF.

TABLE 1

318. 'PTS Svstem 2 -CAT TCA- 166 465 Reverse

319. --Fucose Isomerase (EC 5.3.1.-) - 1 -CAT CTA- 9 482 Reverse Escherichia Coli.

320. Unknown 2 -CAT TTA- 495 650 Reverse

321. Unknown 1 ATG TGA 130 231 Forward

322. 3-Oxoacyl-[Acyl-Carπer Protein] Reductase 1 -CAT TCA- 51 200 Reverse (EC 1.1.1.100) (3-Ketoacyl- Acyl Car Rier Protein Reductase). - Escherichia Coli.

323. 3-Oxoacyl-[Acyl-Caπier Protein] Reductase 2 -CAT TCA- 231 614 Reverse (EC 1.1.1.100) (3-Ketoacyl- Acyl Car Rier Protein Reductase). - Escheπchia Coli.

324. 2-Isopropylmalate Synthase (EC 4.1.3.12) 1 -CAT TTA- 31 231 Reverse (Alpha-Isopropylmalate Synthase) (Alph A- IPM Synthetase). - Lactococcus Lactis (Subsp. Lactis) (Streptococcus Lactis).

325. 2-Isopropylmalate Synthase (EC 4.1.3.12) 2 -CAT TCA- 191 334 Reverse (Alpha-Isopropylmalate Synthase) (Alph A- IPM Synthetase). - Lactococcus Lactis (Subsp. Lactis) (Streptococcus Lactis).

326. Unknown 3 -CAT TCA- 309 452 Reverse

327. 2-Isopropylmalate Synthase (EC 4.1.3.12) 4 -CAT TTA- 495 1 127 Reverse (Alpha-Isopropylmalate Synthase) (Alph A- IPM Synthetase). - Lactococcus Lactis (Subsp. Lactis) (Streptococcus Lactis).

328. Unknown 2 -CAT TCA- 170 469 Reverse

329. Unknown 1 ATG TAG 105 473 Forward

330. Strscaa Ncbi gi: 310629NCBI gi: 473 - 1 -CAG CTA- 81 665 Reverse Streptococcus gordonn (strain PK488 DNA ...

353. PSEGLI NCBI gi: 499660 - Pseudomonase 1 -CAT TTA- 50 481 Reverse J putida.

354. Unknown 1 CTG TAA 1 522 Forward

355. Thioredoxin. - Streptomvces Clavuligerus. 1 ATG TAG 58 375 Forward

356. D-alanine permease (dagA) homolog - 1 ATG TAG 185 343 Forward Haemophilus influenzae (strain Rd KW20)

357. Unknown 1 -CAT TTA- 78 371 Reverse

358. "DNA Polymerase III 1 -CAA TCA- 82 561 Reverse

359. Transport ATP-Binding Protein Coma. - 1 -CAT TTA- 112 552 Reverse Streptococcus Pneumoniae.

360. Unknown 2 ATG TAA 445 540 Forward

361. surface protein PspA - Streptococcus 1 -CAT TCA- 45 416 Reverse pneumoniae

362. Licid Protein. - Haemophilus Influenzae 2 ATG TAA 268 633 Forward

363. Unknown 2 ATG TAA 527 640 Forward

364. Glutamine Transport ATP- Binding Protein 1 CTG TGA 1 393 Forward GLNQ. - Escherichia Coli.

365. Unknown 1 ATG TAG 184 303 Forward

366. Unknown 1 ATG TGA 794 919 Forward

367. Lipoamide Dehydrogenase Component (E3) 1 ATG TAA 3 416 Forward of Pymvate Dehydrogenase Complex (EC 1. 8.1.4) (Dihydrolipoamide Dehydrogenase). - Azotobacter Vinelandii.

Codon Position

SEQ ID NO: Identity ORF # I Start Stop Start Stop Direction

368. Orotate Phosphoribosyltransferase (EC •CAT CTA- 21 311 Reverse 2.4.2.10) (OPRT). - Bacillus Subtilis.

369. Unknown ATG TAA 28 309 Forward

370. SPO0B- Associated GTP-Bindiπg Ptroein. ATG TGA 110 538 Forward Bacillus Subtilis,

371. Transport ATP-Binding Protein COMA. - -CAA TCA- 47 679 Reverse Streptococcus Pneumoniae.

372. prephenate dehydrogenase (EC 1.3.1.12) - ATG TAG 271 492 Forward lactococcus lactis.

373. O-Syaloglycoprotein Endopeptidase (EC CTG TAA 450 Forward 3.4.24.57) (Glycoprotease). - Pasteurella Haemolvtica.

374. Unknown -CAT TTA- 282 Reverse

375. Unknown TTG TAA 265 Forward

376. 'DNA Polvmerase III ATG TGA 401 Forward

377. Unknown ATG TAA 361 516 Forward

378. Dihydrodipicohnate Synthase (EC 4.2.1.52) -CAT TTA- 179 457 Reverse (DHDPS). - Bacillus Subtilis.

379. Unknown -CAT TCA- 104 322 Reverse

380. Unknown -CAT TCA- 248 649 Reverse

381. Unknown -CAT TTA- 56 394 Reverse

382. Unknown -CAT TTA- 254 409 Reverse

383. Unknown ATG TAG 138 617 Forward

384. Unknown -CAT TTA- 225 479 I Reverse

385. Unknown ATG TAA 747 857 I Forward

386. Unknown ATG TAG 294 443 I Forward

387. Unknown ATG TGA 356 544 I Forward

388. Unknown -CAT CTA- 141 Reverse

389. Unknown CTG TAG 579 Forward

390. Unknown -CAT TTA- 309 452 Reverse

391. Phosphopentomutase (EC 5.4.2.7). - ATG TAA 233 Forward Escherichia Coli.

392. D-Alanyl-D-Alanine Carboxypeptidase -CAT TTA- 52 537 Reverse Precursor (EC 3.4.16.4) (DD-Peptidase)(DD - Carboxypeptidase)(Cpase)(PBP5). - Bacillus Subtilis.

393. Na-t- and Cl-dependent gamma-aminobutryic TTG TGA 268 Forward acid transporter homolog-Haemophilus influenzae (strain Rd KW20)

394. Unknown 2 ATG TGA 319 546 Forward

395. dihydrolipoamide dehydrogenase (EC 1 ATG TGA 3 284 Forward 1.8.1.4) - Pelobacter carbinolicus

396. Unknown 2 ATG TGA 241 450 Forward

397. Beta-Glucosidase A (EC 1 ATG TAA 184 453 Forward

3.2.1.21 )(Gentiobiase)(Cellobiase)(Beta-D-

Glucoside Glucohydrolase). - Clostridium

Thermocellum.

398. Uracil Permease. - Bacillus Caldolvticus. 1 ATG TAA 93 353 Forward

399. Unknown 2 ATG TAG 127 516 Forward

400. ligoendopeptidase F- Lactococcus lactis 1 ATG TGA 134 310 Forward

401. Stratpasea NCBI gi: 153565NCB1 gi: 4- 2 ATG TAA 392 568 Forward Streptococcus Faecalis DNA.

402. Unknown 2 ATG TAA 376 507 Forward

403. Exodeoxyribonuclease Small Subunit (EC 2 -CAT TCA- 470 682 Reverse 3.1.1 1.6) (Exonuclease VII Small Subunit). - Escherichia Coli.

404. ATP-Depenent DNA Helicase RECG (EC 1 ATG TGA 3 455 Forward 3.6.1.-). - Escherichia Coli.

468. Unknown 1 ATG TGA 385 492 Forward

469. Unknown 2 ATG TAA 587 721 Forward

470. galE protein - Neisseria meningitidis 1 -CAT TCA- 23 460 Reverse

471. Unknown 2 -CAG TTA- 717 1319 Reverse

472. Naphthoaie Synthase (EC 4.1.3.36) 1 ATG TGA 97 414 Forward (Dihydroxynaphthoic Acid Synthetase )(Dhna Sy Nthetase). - Escherichia Coli.

Table 2 shows the correlation between the SEQ ID NO of each DNA sequence of the invention with the SEQ ID NO(S) of polypeptide or polypeptides that its open reading frame(s) encodes. For example, the DNA of SEQ ID NO:l encodes one polypeptide, that of SEQ ID NO:224. Whereas, the DNA of SEQ ID NO:2 encodes two polypeptides, the polypeptides of SEQ ID NO:225 and SEQ ID NO:226.

TABLE 2

DNA Protein (open readingframe)

=_-__ ==____==

1 224

2 225,226

3 227

4 228,229,230

5 231

6 232

7 233

8 234

9 235

10 236

11 237

12 238

13 239

14 240

15 241

16 242

17 243,244

18 245

19 246

20 247,248

21 249,250

22 251

23 252

24 253,254

25 255,256

26 257

27 258

28 259

29 260,261

30 262 73 314

74 315,316,317

75 318

76 319,320

77 321

78 322,323

79 324,325,326,327

80 328

81 329

82 330

83 331

84 332

85 333,334

86 335

87 336

88 337

89 338

90 339

91 340

92 341

93 342

94 343

95 344,345

96 346

97 347

98 348

99 349

100 350

101 351

102 352

103 353

104 354

105 355

106 356

107 357

108 358

109 359

110 360

111 361

112 362

113 363

114 364 115 365

116 366

117 367

118 368

119 369

120 370

121 371

122 372

123 373

124 374

125 375

126 376

127 377

128 378

129 379

130 380

131 381

132 382

133 383

134 384

135 385

136 386

137 387

138 388

139 389

140 390

141 391

142 392

143 393

144 394

145 395

146 396

147 397

148 398

149 399

150 400

151 401

152 402

153 403

154 404

155 405

156 406 157 407

158 408

159 409,410

160 411

161 412

162 413

163 414

164 415

165 416

166 417

167 418

168 419

169 420

170 421

171 422

172 423

173 424

174 425

175 426

176 427

177 428

178 429

179 430

180 431

181 432

182 433

183 434

184 435

185 436

186 437

187 438

188 439

189 440

190 441

191 442

192 443

193 444

194 445

195 446

196 447

197 448

198 449

SEQUENCE LISTING (1) GENERAL INFORMATION

(i) APPLICANT: Black, Michael Hodgson, John Knowles, David Nicholas, Richard Stodola, Robert

(ii) TITLE OF THE INVENTION: Novel Compounds

(iii) NUMBER OF SEQUENCES: 477

(iv) CORRESPONDENCE ADDRESS:

(A) ADDRESSEE: SmithKline Beecham Corporation

(B) STREET: 709 Swedeland Road

(C) CITY: King of Prussia

(D) STATE: PA

(E) COUNTRY: USA

(F) ZIP: 19406-0939

(V) COMPUTER READABLE FORM:

(A) MEDIUM TYPE: Diskette

(B) COMPUTER: IBM Compatible

(C) OPERATING SYSTEM: DOS

(D) SOFTWARE: FastSEQ for Windows Version 2.0

(vi) CURRENT APPLICATION DATA: (A) APPLICATION NUMBER: <B) FILING DATE: 01-APR-1997 (C) CLASSIFICATION:

(vii) PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: 60/014690

(B) FILING DATE: 02-APR-1996

PRIOR APPLICATION DATA:

(A) APPLICATION NUMBER: 60/025788

(B) FILING DATE: 22-AUG-1996

(viii) ATTORNEY/AGENT INFORMATION:

(A) NAME: Gimmi , Edward R

(B) REGISTRATION NUMBER: 38,891 (C) REFERENCE/DOCKET NUMBER: P50466

(ix) TELECOMMUNICATION INFORMATION:

(A) TELEPHONE: 610-270-4478

(B) TELEFAX: 610-270-5090

(C) TELEX:

(2) INFORMATION FOR SEQ ID NO:1:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 683 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1 :

CTCAAACATG GTCTCTTCTA GTTGCATGGT CGCAATCGGA TCCAAGGCTG AGGCTGGGCT 60

CATCCATTAA GAGGATATCT GGCTTAACAG AGATGGCACG AGCGATACAG AGACGTTGTT 120

GCTGACCACC TGATAAGGTC AAGGCTGACT TGTGGAGATC GTCTTTAACC TGATCCCAAA 180

GGGCAGCCTG ACTAAGGGAG GTTTCTACGA TTTCATCTAG GACTTGCTTA TCCTTAACTC 240

CAGCACGTTC ATGCGCAAAG GTAATATTAC GGTAAATTGA CTTAGCAAAT GGATTGGGGC 300

GTTGAAAAAC CATTCCAATG TGTTTACGCA TTTCATAAAC GTTGATTTCT GGACGGTTGA 360

CATCAATTCC ACGATAGAGA ATCTGCCCAG TTACTTTAGC AATATCAATG GTATCATTCA 420

TGCGATTGAG ACTGCGTAAG TAGGTAGATT TCCCCGATCC CGACGGACCA ATCAAAGCTG 480

TAATTTTATT TCCTTTCAAA TTGCATATCA ATCCCCTTAA TGGATTCATT TTTACCATAG 540

TAAACATGGA CATCCTTAGT AGAAAGGGCT ACTTTTTCTT CAGGAAAGGT AAGGATATGC 600

TTCTCATCCC AGTTATATGT TGACATGGCT TCTCCTTTAG GCAGCGGTTA ATTTCTTGTG 660

TAGATAGCTT CCGAACTTAC GAG 683

(2) INFORMATION FOR SEQ ID NO:2:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1512 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: CTAGTCCAAC TAACTGAGTT TTCCTTTATC TATTATATCA AATATAAGTC CGTTTGTAAC 60

TAGTGAAGAA TTCTTTTGTC CGCTCTTCTT TAGGGGTGTG GATAATCTCA TCCGGAGTTC 120

CAGACTCGAT GATTTTCCCC TTATCTAAGA AGAGAATTTT ATCCGCAACT TGGGCTACAA 180

AGGGCATGTC ATGACTGACC AAAATCATGG TCTGACCTGA CTTAGCAGCA TCTGCAATAG 240

ACTTTTCTAC TTCACCGACC AATTCTGGGT CAAGGGCTGA AGTTGGTTCG TCTAAGAGCA 300

AAACATCTGG TTTCATAGCA AGCGCACGCG CTAGGGCAAC CCGTTGCTTC TGTCCACCTG 360

ATAAATGGCG AGGATAATGG TTTTCACGGT CCGAAAGCCC AACCTTAGCC AACTCTTCCT 420

TGGCAATCTT AGTCGCTTCT TGGTCAGATA ATTTCTTGAC AACAACCAAG CCTTCTTTCA 480

CATTATCAAG TGCTGTTCGG CGTTCAAATA AATTAAACTG TTGGAAAACC ATAGACAACT 540

TACGGCGTAG GGCAAGGATT TCTTCT GAG TGATTTTAGA AAAATCAACT GAAAAACCAT 600

CAATCTGAAT AGAGCCACTG TCAGGTGTTT CAAGATAATT GAGACTGCGA AGAAAGGTTG 660

ATTTTCCAGC TCCTGAAGAA CCAATCAAGG CTACAACTTC CCCTTTTTGA ATATCCAAGT 720

TCAGATGATC CAAGACAGTC TGTCCTGAAA AGGATTTGCT TAAATTCGAA ATCTTAATCA 780

TTAACGAAGG TCTCCTTTCA CATCTGTTTG CACTGTATCA GGTGCAGAAA TAGCCATTTT 840

TCTCTCGATG AAACGACCGA GGCTTTCAAT TCCGATATTG ACTACCCAAT AAACAAGGGC 900

AACAGAGATG AAGCGTTCAA AATAGCGATA ATCAGCTCCA CCTAGAATCT GAGCTTGGGC 960

AAAGACTTCC ACAACACCCG CACTAAAAGC TAGAGATGTT CCCTTGGTCA AACCGATGAG 1020

GGAATTAATC AAGGTTGGAG TAGCTACCAC CGCTGCATTA GGAATAATCA CTCGTCGATA 1080

AACTTGCGCT CGGGTCATAC CCAGACTGCG CGCCGCCTCA ATCTCACCAG GATTAACTGA 11 0

GAGAATGGCT GCACGAATGG TTTCACTAGC ATAAGCTGCC TCATTAAAGG CAAAAGCGAC 1200

AATCGCAAAA GCTGCAGCTG GAATCGCATT GATATTG GA CCAGTTCCCC ATTGCTGATT 1260

GAGGGCTTTC AAAGCCAAAG GGATTCCGTA GTAGGTCAAC ATGAGTTGCA CCAAAATCGG 1320

TGTCCCTTTT AAGAAACTAA CAAAGAAGGC CTGCAAGGGA TATAAAATCT TGACACGATT 1380

GATCTTCACA ATGGCAAAAA GAAGCGCCAA AACCAAGCCA AAAAGGGCAC CGCCAATTGT 1440

CAACATAATT GTTGTTGGAA GTTGTTGGAC AATTCTAGGG ATTCCATCAA AGACCGAACG 1500

TAGGCTAAAC AG 1512

(2) INFORMATION FOR SEQ ID NO: 3 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 709 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:3 :

CTGGAGATTA TTGAGATTGC CCGTCAAAAC GATTTGATTA TNTTTGCGGA TGAAATCTAT 60

GACCGCATGG TAAATGGACG GACATGTGCA TAACGCCTGT GGCGAGCTTG GCACCAGATG 120

TCTTCTGTGT CAGCATGAAT GGTCTGTCAA AATCCCACCG CATAGCAGGT TTCCCGTGTG 180

GGATGGATGG TCTTGTCTGG CCCTAAGACT CATGTTAAGG GCTATATCGA AGGGCTCAAT 240 ATGCTGTCCA ATATGCGCCT TTGCTCTAAC GTTTTGGCTA CCAACGCTGC ATTAGGAATA 300

ATCACTGTCG TACAAACTTG CGCTTGGGGG GTCACCAATC AGTCGATGAA TTGCTTCTTC 360

CTGGTGGACG AATCTACGAG CAAAGAAATT TCATCTATAA TGCCATTCAA GATATTCCAG 420

GTTTGTCTGC CGTTAAACCC AAGGCGGGGC TCTATATCTT CCCAAAAATC GACCGCAATA 480

TGTACCGTAT CGATGATGAT GAGCAGTTTG TCCTTGATTT CTTGAAGCAG GAAAAGGTTC 540

TCTTGGTTCA TGGTCGAGGC TTTAACTGGC AGGAACCAGA CCACTTCCGT ATCGTTTACC 600

TTCCTCGTGT TGATGAGTTA GCCCAAATCC AAGAAAAGAT GACTCGTTTC TTGAAACAGT 660

ATCGTAGATA GGGCTTGCAT TCGAAAAAGC TGGAAACATT TGCCTAGAG 709

(2) INFORMATION FOR SEQ ID NO: :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1588 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4:

CTGCTTCAGA ACCTGCCAAA CCAGCACCGA TAACATTGAT ATAAGATTGA GACACGACAC 60

TAATACCTCT TTGGGAGTGT GAAGTTAAGA TTCACATTGA AAAAGCCAAT CAGACTT CA 120

AGCTTTCGAG TTTCTTGGCT CAGGCTGAAA AAGTCCACAG GGCTTTTNCA CTCCCACAAA 180

TCTTTCTATT TTTTCTNCTA CTAGTATAAC AAAAAAAGGG AAGAAGGNAA ACTTCCCTGT 240

TTAGTCATTT TCTTGATGTA AAGAGATAGT GAGTATTCCA GTTAAGAATC AATTATATGC 300

TACTCTATAA AATCTTTTCC ACATAACGGA TCGATAGGGA CTGTTATTCT ATCTCTTGCT 360

ATAACCGTAT TATCTAAAAC AGCATAACAT TCAACATAGT GATCTCCTTT AAACTGTGAA 420

TCTTCCGTGA TATTTTATTT TACCTGAAAA AATAGCACAC GCTCACAATT CTTCCTAATA 480

GCCTCAGCTT CAATATTTCT TACTTTCCAA TAGACTCCCT GCGAAACAAA ATATGGTATA 540

GTAGTTCTAT GAATGATGAA GCAAGTAAAC AACTAACTGA TGCACGATTT AAGCGTCTTG 600

TTGGTGTTCA GCGCACGACT TTTGAAGAGA TATTAGCTGT ATTAAAAACA GCTTATCAAC 660

TTAAACACGC AAAAGGTGGA CGAAAACCTA AATTAAGCCT AGAAGACCTT CTTATGGCCA 720

CTCTTCAATA TGTGCGAGAA TATCGAACTT ATGAACAAAT TGCGGCTGAT TTTGGTATCC 780

ACGAAAGCAA CTTAATCCGT CGGAGCCAAT GGGTTGAAGT AACTCTTGTT CAAAGTGGTG 840

TTACGATTTC AAGAACTCCT CTCAGTTCTG AGGACACGGT AATGATTGAT GCGACGGAAG 900

TACAAATCAA TCGCCCTAAA AAAAGAATTA GCGAATCATT CTGGTAAAAA GAAATTTCAC 960

GCTATGAAGG CTCAAGCGAT TGTCACAAGT CAAGGGAGAA TTGTTTCTTT GGATATCGCT 1020

GTGAACTATA GTCATGATAT GAAGTTGTTC AAAATGAGTT GCAGAAATAT CGGACAAGCT 1080

GGAAAAATCT TGGCTGATAG TGGTTATCAA GGGCCCATGA AGATA ATCC TCAAGCACAA 1140

ACTCCACGTA AATCCAGCAA ACTCAAGCCG C AATAGCTG AAGATAAAGC TTATAACCAT 1200

GCGCTATCCA AGGAGAGAAG CAAGGTTGAG AACATCTTTG CCAAAGTAAA AACGTTTAAA 1260

ATGTTTTCAA CAACCTATCG AAATCATCGT AAACGCTTCG GATTACGAAT GAATTTGATT 1320

GCTGGCATTA TCAATTATGA ACTAGGATTC TAGTTTTGCA GGAAGTCTAT TATTTTCCTT 1380 ATTGTCTGTA AGTCTACTGA CCTTGTTGTT TATCCCAGTC ATGGTTTCTA GTTCGGGCTC 1440

AGAGTTTCAA AGTGGATGGC AAGAGCATCA ATTGATTGCT GAGAAGGTTA GTAAAACACT 1500

TGACAAGACA TTTGATAAGG ATGTCAGAAA AATTCCGACC AGTCCAGTTT TATCAAAAAT 1560

TTGTAGATGA GATGGGAAGG ATTTACTC 1588

(2) INFORMATION FOR SEQ ID NO:5 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 690 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:

CTGTTTTTAA TACAGCTAAC ATCTCTTCAA AAGTGGTACG CTGAACACCA ACAAGACGCT 60

TAAATCGTGC ATCAGTTAGT TGTTTACTTG CTTCATCATT CATAGAACTA CTATACCATA 120

TTTTGTTTCG CAGGGAGTCT AATATTGTCA AATACTGGAG CGCTCATTGC TGGTATACGG 180

AATAAGATTG GCCCAGCTTC GATAACTGGG ATACCTGGTT CAAAACCAAG ATCTGTTGCA 240

GCGATTGGTG TAAAGATATC GTAACCTTTC ATAAGGTCTT CGTTTACATC TTTCACCATG 300

ACTGCATCAC AGTGAACATC ATAACCACGG TTTGAAAGTT CTTCTTCTAG AGCACTTTTA 360

ATTTGGTGAC TTGAGTTAAC ACCTGCACCG CAGGCAGCAA GAATTTTAAT CATTTAGATT 420

TCCTCCGATT TTATTTTTTA ATAGACAAGA TTAAGCGGTT GCTTCAGCAA TGTAAGCATA 480

AAGTTTTTCT GGTTCGGAAA TTTTTGATAG GTCTTCAAGA TGTCCATTTC CTGTGAAAAA 540

GTCCATCAAC TGAGCCAGAA TATTTGTTTG ACTTGAACTT GAGTTATTGA TGATAAAGAA 600

GAGCAAGGAT ACTTCTACTT CCTTATCAGG AGCTATCATA TTGTGAAAAG TTACTGATTT 660

TTCTAATCGA ACAACCACCA CTTTTCTCAG 690

(2) INFORMATION FOR SEQ ID NO: 6 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 339 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6:

ACTGCTACCT TTAAGAAGAT AGTAGACGTA TATACTTTTT TAAGAAAATC AAAAAGATAC 60 TATAAAAAAT CTATTTGTTT ATTGAATTTA AGACTTTGGT AACAAATTGA AAATAAAAAG 120 GAGGTATTCA TCATGAATAC AAAAATGATG TCACAATTTT CTGTTATGGA TAATGAAATG 180

CTTGCTTGCG TTGAAGGTGG AGATATTGAT TGGGGAAGAG AAATTAGTTG TGCAGCAGGG 240

GTTGCATATG GCGCAATTGA TGGGTGTGCA ACAACGGTTT GATATTTCTA TTGGGACCAT 300

TTGCTATAGG AATAGGTGTA ACTGGTGCTG CAGGTGGAG 339

(2) INFORMATION FOR SEQ ID NO:7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1693 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:7:

CTGAAGACCT CGTGCTACTC CTCCTCCAAC ACCTGCTTTG GCAAAATCTC CCCAATTGCA 60

TCCGCCACCT TCAACTCAAG CAAGCATCTC AGTATCCATA ATTTCAAATT GTGACATCTT 120

TTTTGTATTC ATAACGAATA CCTCTTTTTT ATTTTTAATA TTTGTCTTGT TACAAACTTG 180

ACAAGTTTAG TATAACAGTA TCTATTAATT TTTTTCATCC AAATCTTGAA TTGGCATCGA 240

AACGTCTTGA ATTAGCTTTT TTGTTTCAAA ATCATCTCTA TTTTTAAAAA AGATGTTTTC 300

TAATCACTTT TTTACTATTT AGACTTCCTG CAAAACTAGA ATCCTAGTTC ATGATTGATA 360

ATACCAGCAA TCAAATTCAT TCGTAATCCG AAGCGTTTAC GATGATTTCG ATAGGTTGTT 420

GAAAACATTT TAAACGTTTT TACTTTGGCA AAGATATTCT CAACCTTGCT TCTCTCCTTA 480

GATAGCGCAT GATTACAGGC TTTATCTTCA ACTGTTAGCG GCTTGAGTTT GCTGGATTTA 540

CGTGGAAGTT TGTGCTTGAG GATATATCTT CATGAGCCCT TGATAACCAC TGTCAGCCAA 600

GATTTTACCA GCTTGTCCGA TATTTCTCAT TTCTAAAAAC CATCTACTTC CGTTGACTTG 660

GAACTCCGAT TGCTATTTTC CTTGAATGAT TTTAACCACA TCTCCTACAC TTTGGAGTTG 720

GTCAATTTCC TCATCGCTGA TTTCGATACT AAATTCATCC TCCAGCGTCA AGATAAACTC 780

CATCAAATCA ACTGAGTCAG CATCCAAGTC GTCTTTCAGA CTCAAGGATT CTGTCACGAC 840

AAAGTCCTCT CCCTGTCGCT CTTGGATAAT GGTCACAATA CTGTCAAAAA TTTCTTTTTC 900

TCTCATCTCT TTTATTCTCC TGAAAATTCA CGCGCAGTCT GGGCAACTAC TTCTGTTTCT 960

AGCATGGTAC GAATCTGGCG AATCGTACTA TAAACAGCCT TGGCATCGCT TGAGCCATGA 1020

GTCTTGACAA CAGGTGCCTT GACACCAAAC AAGACCGCTC CACCAACATC TGAATAATTG 1080

AGCTGTTTTT TCAAACCTCT GAGGCTGTCC TTGAGAAGGA GGGCACCTAG TTTCGCTCGA 1140

AGACCACCAC CTGTAATAGC TGTCTTGAGC AAGCCCATGA TTCCCATAGC TGTCCCTTCG 1200

ATGGATTTGA GCACAGCGTT TCCCGTGAAA CCATCTGCCA CAACAACATC TGCAACGCCA 1260

TTCATCAAAT CACGCGCTTC CACGTTTCCG ATAAAGTTCA AACTTTCATC AGCCGCCAGT 1320

AATTCATAAG TTTCCTTACG AAGCGGGTCG CCCTTGCTAC TCTCTGTTCC GTTGTTGAGC 1380

AAACCAACAC GTGGTTGCGC AATGCCACGA ACATTCTTGG CATAGAAAGA ACCTAGGACA 1440

GCGTATTGAT GGAGGTGCTG GGCTGTATTT TCTGCATTAG CACCGAGGTC AAGCATGTCA 1500

AAACCTTTCC CATCTACAGT CGGCAATGTT GACATAAGTC CAGGACGGTC GATATTCTTG 1560

ATACGACCCA CGATGAAGAA TCCAGCAGCC AACAAAGCAC CTGTATTCCC AGCCGAAAGG 1620 ACAGCGTCTG CTTCACCATC TTTGACAGCC TTGGCTGCCA ATACCATACT GGCATTTTTC 1680 TTATTCCGAA TAG 1693

(2) INFORMATION FOR SEQ ID NO:8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 616 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8:

CTAAATCTGC TTGCTTAGTC CACTTGCTTG AGCCAAGGAG TCACATACTC AAAATTTTCA 60

TGAAAGTCAT AGGTACCGTC TTCTTTTTTA GCTGAAAAGA AAAGTCCATC GTGGTAGAGC 120

AAATCCCCGT GGGCCATAAT TCTGGCAGTT TTTTCCTCTT CCTACTCCTG AGACTTTTGC 180

TTAGTCCCCT CTTGAGAAAT AGTATCTCGT TTTTGACTAG TCAAGGGATT CCTTGGAAGC 240

TTTCAAACAA CAAGACCAAG CCCATTGATA AACCAACTGC TAGCAAGAGT ATCGCCACAA 300

ATCCCTTATT GCTCCACTTG CGATAACTCC TAAAAAGTTT ACCAAGCCCT TCATAAAACG 360

AAAAGCTAAA CCACCCTGAT TTCGATTTTG TCTTCTTTGT ATCTTCGTTC TCCCTACTTT 420

CTTATGCAAG CCTTTTCTTT TTATTATATC ACAGATAAGT ATTTCTTTCA CAATTGAATT 480

GAACTTCCCA TCTATTTTCT ATAAATCCTA AATGCCATAA TGCTTTCAAT TCCTGTCATT 540

TTGTGATATC ATGTAGAAGA AATGAACTAA TCCACAGTGG CTTATTCCAA GTATACCACT 600

TGGGCTTTGG CAGTAG 616

(2) INFORMATION FOR SEQ ID NO: 9 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1973 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9:

CTAATATAGA ATAATCACCG CCGTTGTGAA AGAACGATTG GATGATAATC CAATCGTTCA 60

GGGAAATTGG AAGACCTTGG GTTTCCAATT TAGGCATGAG ACACCTTTGG TGGCTGCTGC 120

CGTCCCTCAC AAGCTAAGGT GATTGTTGAA AAAGAGGAAA AAGGAGAAGA AATGAAACCA 180

GTAATTTCCA TCATCATGGG CTCAAAATCC GACTGGGCAA CCATGCAAAA AACAGCAGAA 240

GTCCTAGACC GCTTCGGTGT AGCCTACGAA AAGAAAGTTG TTTCCGCACA CCGTACACCA 300 GACCTCATGT TCAAACATGC AGAAGAAGCC CGTAGTCGTG GCATCAAGAT CATCATCGCA 360

GGTGCTGGTG GCGCAGCGCA TTTGCCAGGC ATGGTAGCTG CCAAAACAAC CCTTCCAGTC 420

ATTGGTGTGC CAGTCAAGTC TCGTGCTCTT AGTGGAGTGG ATTCACTCTA TTCTATCGTT 480

CAGATGCCGG GTGGGGTGCC TGTTGCGACC ATGGCTATCG GTGAACTCTT TTTTAGGATA 540

TAAAACAGGG TTCGGATAAG TTTTTTTGCA AGGTGGATGA TGGCTACATT GTAATGTTTT 600

CCTTATTCTA ACTTAGTCTT AAGATAGGTC TTAAAACCAG GTGAAAAGCG AAGGCATGCT 660

TTGGCAGCTT GTATGAGTAC CTACCGCAGA TGAAGGGAAC CCCGTTTGAC CATCCTTCCA 720

ACTAAATCAA TCTGACCTGA CTGATAAATA GAAGAATCCA GTCCAGCGAA AGCTTGTAAT 780

TGAGCAGGAT TATCAAAGGC ATGAATATTT CGAATCTCGG CTAAAATGAC CGCCCCTAAA 840

CGATTCTCAA TCCCAGTAAC CGTCGTGATG ACCGAGTTTA ACTCAGCCAT CAAGTCATTG 900

ACACATTTTT CCGCCTTGTC AATGAGCCTC TTGTAATGTT TGATGTTTTC ATTACACGAG 960

ATAAAACGTC TATGCGTTAT CAAACTCATT ACCAATTAAA ACAAATGTGG TTAGATCCTT 1020

TCGGAAATTG TCAAGCGATT GGAGGAAATG AACTAATCCA CAGCGGCTTA TTCCAAGTAT 1080

ACCACTTGGG CTTTGGCAGT AGCTAACTGC GCTAAATATA ATATAAGGAG GAGTAAAATG 1140

AAGACAGTTC AATTTTTTTG GCATTATTTT AAGGTCTACA AGTTCTCATT TGTAGTTGTC 1200

ATCCTGATGA TTGTTCTGGC GACTTTTGCC CAAGCCCTCT TTCCAGTCTA TTCTGGACAA 1260

GCGGTGACGC AGCTAGCCAA TTTAGTTCAA GCTTATCAAA ATGGGCAATC CAGAACTTGT 1320

ATGGCAAAGC CTATCAGGAA TTCATGGTCA ATCTTGGCCT GCTGGTTTTG GGTTCTATTT 1380

ATCTCTAGGT GTAATATAAA CATGTGTCTC ATGACGCGCG TGATTGCAGA ATCGACCAAC 1440

GAGATGCGCA AAGGTCTCTT TGGTAAGCTT GCTCAGTTGA CGGTTTCTTT CTTTGACCGT 1500

CGACAAGATG GCGATATCCT GTCTCATTTT ACCAGTGATT TGGATAATAT CCTCCAAGCC 1560

TTTAACGAAA GCTTGATTCA GGTCATGAGC AATATTGTTT TATACATTGG TCTGATTCTT 1620

GTCATGTTTT CGAGAAATGT GACGCTGGCT CTCATCACCA TTGCCAGCAC CCCATTGGCT 1680

TTCCTTATGC TGATTTTCAT CGTGAAAATG GCACGTAAAT ACACCAACCT CCAGCAGAAA 1740

GAGGTAGGGA AGCTCAACGC CTATATGGAT GAGAGCATCT CAGGCCAAAA AGCCGTGATT 1800

GTGCTAGGAA TTCAAGAGGA TATGATGGCA GGATTTCTTG AACAAAATGA GCGCGTGCGC 1860

AAGGCAACCT TTAAAGGAAG AATGTTCTCA GGAATTCTTT TCCCTGTCAT GAATGGGATG 1920

AGCCTGATTA ATACAGCCAT CGTCATCTTT GCTGGTTCGG CTGTACTTTT GAA 1973

(2) INFORMATION FOR SEQ ID NO: 10:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1209 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:10:

CTAAACCAAT AGTTGCTGAA GACCATAATC CAGCTGCTGT TGTTAAACCT TTAACTTTTT 60

GATTAGTTAC CATGATTGTT CCTGCCCCTA GGAAACCCAA GCCACTAATT ACTTGGGCTC 120

CCATTCGACT AGGATCACCG CTACCATAAC GACTAGTGAT GAACTGATTT GTCATCATTA 180 CAACACAAGT TCCCAAACAA ACTAGTAAGT AGGTTCTAAT CCCTGCTGCT TGGTTTTTGA 240

CTCCTCGCTC ATAGCCAACA ATGCCACCGA AAAGAATCGC TAAAAAGCAC CTAAGAAGTA 300

TTTCCCAAAT ACTCAGTTCG TATGAAAGAT TCATATTATC TCTTACCTCG TTTACCTTGG 360

AATAGGCTTG ATAAATAAAG AGCTGCACTA GACATAATCA TTAAAATTAC AGAATAAACA 420

AACATCATTG CCTGTGCATT TAAAGTTGCT GTTTCATCAG TAGACTGTTT AATAACGATT 480

CCCAATGGTT GGAAAAGTGG ATGGTACAAG AATACAGATA AGTCATAGTC AGATAATAAA 540

GAATTAAAGT TTAACACAAC TACTGATAAT ACGACTGGTA AAATATACGG TATAATAACT 600

CGCACCATAG TGTAGAAACT AGATGCACCC ATACTACGTG CAGCTTCTTC CATATCATTA 660

TCTATACTGA AAAATACAGC CCGAATCATT CTATAAGAAA ATGGTAATTT TTGAATAGTA 720

TATGCAATAA GTAAAATAAT TACTGTTCCT ACTAAAACTA AATTAAATAG TATTAAATGA 780

GGTATATTAT AAGTGAACAT TAATCCTAGT GCAATCAATG TACCTGGCAA TATCCATGGT 8 0

ATCAGTGCAC CATACTCAAA GAATTTATCG AACTTACTCT TGTTTTTATG TACAATACGT 900

GAAATTACTA TTGCTATAAT TGTAGCAATT ACCGCAGCTA AAATTGCATA AACAACGCTG 960

ACTAGGTAAG GACGAAATGA TTGAGCATCT GTAAATAAAT TAGCATAGTT CGCTAACGTA 1020

AATTTAGATA GATCTAAAGT TCCCGTCTTG ATCGTCAACG AGTCTGTAAA CGAGTATAGA 1080

ATTATCAAAA CTATTGGTAA CAT TAGATT GCAAACAATA CATACGCAGC AATGTGAGCA 1140

AGAATTATTC CATAATGGAG AAGAAAATTA TCTGCTTCCT TAATACTAGC CTGGTTTTCG 1200

AAACAGAAT 1209

(2) INFORMATION FOR SEQ ID NO: 11:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 717 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11:

CTAAGTCCTT TTAGTTTTAT CTTAATTCTC TTATTGTTGT AATAATCAAT ATAGTCTATA 60

ATGGCTTGTT CCAATTGCTT AAGCGACTGA AACGACTTCT CATAACCGTA AAACATTTCC 120

GATTTCAGAA TCCCAAAGAA AGATTCCATC ATACCGTTGT CTTGGCTGTT TCCCTTGCGT 180

GACATAGATG CTTGAATTCC CTTACTCTTA GGAACCGATG ATAAGAATCG TGTTGGTATT 240

GCCAGCCTTG GTCACTATGG AGAATCGTAT TCTCGTAGTG CTTCTCTGTG AATGCCTGTT 300

CCAACATTGT TTGTACTTGT TCTAAGTTGG GTGAAGTTGA AAGATTATAG GCGATAATTT 360

CGCTATTAAA GCCATCTAAA ACTGGTGATA AGTAAAGCTT TTGAGTACTT GCTGGAATGG 420

CAAATTCTGT CACATCTGTG TAGCACTTTT CCATTGTTTT AGAGCCTTCA AATTGGCCTT 480

GAATGAGATT CTCTGCCTTC TTACCAACGT CTCCTTTATG AGAAGATTTC GTTTCTGTCG 540

CATTTTAGCT TGTAAATTGA GTACTTTC T CAAGCCTTGA ACTCTTTTAT GATTTACCAG 600

ATAAGCACGA TTCCTTAGTT CTAAATGAAT ACAGCGATAA GCATAATTTC CCTTGTGTTC 660

GATAAAAATG GATTGAATTT CAGCTTTAAG CTCTTGGTCC TTATCTGGTT TGTNTAG 717 (2) INFORMATION FOR SEQ ID NO:12:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 851 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:12:

CTAAATCACC AGATTTAACC AAGTCGTAGA TACGGCCTGG TGTTCCAATA ACAATATGAG 60

GCTGATTGCT TGCCAATTTC TCAATCTGGC GAGCCTTATC CGTACCACCC ACATAATTAA 120

CCACACGAAC TTCGACATCT GAGTGAGCTG AAATCTGACG CGCTACTTGG TAAATTTGAG 180

TAGCCAACTC ACGACTCGGT GCAGTAATCA CTGCTTGTAC ACTATCGCTA GCTTCATCTA 240

ATTGCTGGAA AATCGGTAAC AAGAAAGTAT GAGTCTTACC TGAACCTGTT TTTGATTCTC 300

CTACTAGGTC ACGACCTGCC AAAACAATAG GAATCAACTT GTCTTGCACC TCTGTTGGAG 360

TTGTAAATTT TAACTCCTCC AAGGCTTCTC TAATATAGTT TTTAAATTGA AATTTCGTAA 420

ATGACATAAC ATCCTCGATT CTATCTATCT TATCAATTAT ACCATATTTT ATTCCATTAC 480

AGTAGTCTCA CTTATTTAGG CTATTTCCAG TAGCTTCTCT AGTAAGAAAA GGCTGGAATT 540

TTATAGTTCC AACCTCTTTT CAGTTATTAT TTCCAGTTTA ACATAGCATT CAAGCCATAG 600

TGATCACTCA CTTGTGGACT CTTGTTACCA TCAAATACGA CATGTAAATT TTCCACCGCT 660

AACTCTTTGG TAGTAAAGAC ATAATCGATT CGAAGGGGTT CAGTGTTCCC TTTCCAGCCA 720

TCAATTTCAG GCGGAACAGT A AGCTACCA CTTTTCTCTT GAGCAACTTC AAATGCGTCT 780

TGTAAGCCTA ATGGACTAGC TAAAATAGCT TGGTAACCTT CCCTGACCTG CTGGGTTGTT 840

AAAATCTCCA G 851

(2) INFORMATION FOR SEQ ID NO:13:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 541 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:

CTGTTGAGAT TGTTACGAAA TAACTGAAAA TATTTAAGGA GAAAATATAT GTTGAAACAC 60

TTAAACTTAA AAGGTCACTT ATTGACAGCC ATTTCCTATA TGATTCCAAT TGTTTGTGGT 120

GCAGGATTCT TAGTTGCCAT TGGTTTAGCA ATGGGGGGTG GTGTTCCTGA CGCTCTTGTA 180

GCAGGAAAAT TCACTATCTG GGATGCTTTA GCAACTATGG GTGGTAAAGC CCTTGGTCTC 240 TTGCCAGTTG TTATTGCTAC AGGTTTGTCT TACTCGATTG CTGGTAAGCC AGGGATTGCA 300

CCAGGTTTTG TTGTTGGTCT AATTGCCAAT TCTGTTGGTT CAGGGTTTAT CGGTGGTATC 360

TTGGGAGGTT ATATAGTTGG TTTCTTGGTT CAAGCGATTA TTAAAAAGGT CAAAGTACCA 420

AACTGGATTA AAGGTTTAAT GCCAACCTTG ATTATTCCTT TTGTACCTCT TTGGTAAGTA 480

GTTTGATTAT GATTTATATT ATTGGGGCGC CTATCGCAGC CTTTACCAAC TGGTTGACGA 540

G 541

(2) INFORMATION FOR SEQ ID NO: 14:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1324 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 14:

CTGGAATGAG TGTATAAGCC CAGCCCAAGT TTTGCATCCG TTCAAAGTTC CAAGACCCTT 60

GTAAGAAGGT TGAACGCCAC CAAACTTTTT TACGATCTGA TTTAGTTAAT TGAAGTTTTT 120

CAGTCATGAT GTTTTCAGTC CTTTCTTATC TTAGTAGTCT TCTAGGATAT CGCCGATTGG 180

GTCGTTAGAA GTTGCGGCTC CTCCGCCACC ATTTCCACCA GTTTTAGAAA GGTGAAGGTA 240

GATAAGAGCG ATAGCAACAC CGATAGCACC GAATCCGATT AGAGTAATAT CTGACACAGC 300

AGCGAGAACG AAACCAAGAG CGAAGAATGG CCATACTTC CGAGTTGCCA TCATGTTGAT 360

AACCATGGCG TAACCAACGG CAACGACCAT ACCACCACCG ATAGCCATAC CATCTTTGAG 420

CCAGTCTGGC ATGGCACTAA GGATACTTTG TACAGTTTCA GTTGGTACCA TAAGGAGAAG 480

AGCTGCAGGA AGCGCGATAC GAAGTCCTTG GAAAAGTAGC GCAATGAAAT GCGCACGCTC 540

CACAGCGCCG AAGTCACCTT TTTTAGCGGC AGCATCTGCA GTATGAACCA AACCAACTGA 600

AATTGTACGA ACAATCATTG TCAAGAAAAG TCCAGCTACG GCAAGAGGGA TAGCAACCGC 660

TTGGGCAACA CCGATACCAG TCTTGGTAAA GTCACCACCA AGAACCATGA TAATGGCAGC 720

AGCGACAGAA GCAAGTGCAG CATCAGGAGC GATAGCAGCA CCGATATTTG ACCAACCAAG 780

GGCAATCATT TGAAGCGATC CACCGAGGAT AATCCCTGCT TCCAAGTGGA CCTGTTACAA 840

GCCCAATAAG GGTACAGGCT ACAAGTGGTT GGTGAAATTG GAACTGGTCG AGGATGCCTT 900

CAAGACCTGC AAAGGAAGGC TACAACGACT ACTAAAACCA TAGAAATAAT AGACATGTTT 960

AAAATCCTTT CATAAATAAT GGCTTATTTG ACATTGGCTT TGTTAATCAA GTCAAACAAA 1020

TCTTTTTTAG AATCATTTGG TACTTTACGG ACATCAAATT CAACACCCAA GTCACGCATT 1080

TTTTCAAATG TAGCAACATC TTCTTTGTCC ATAGACAAAA CGGTATTGAC CAATGTTTTA 1140

CCTGTTGAGT GAGCCATAGA ACCAACGTTA AGAGTCTTGA TTGGCACGCC GCCTTCGATG 1200

GCACGAAGGG CATCTTGAGG TGTTTCAAAC AAGATAAGGG CATGTGTTTC TCCAAAACGT 1260

GGGTCTTTTG AAATATCAAT CAGTTTTTGA ATTGGAACCA CGTTAGCCTT GACATTACCT 1320

GGAG 1324

(2) INFORMATION FOR SEQ ID NO: 15: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 663 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15:

TCATAAGGAA GCTGTCGCTC GTTCCGCTAA GGTATGGACA CCACGGTGAA CATTGGCATT 60

GTCCTGCTCA TAGTAACTGT TAATAGCTTT CAGAACTACT AGTGGTTTTT GTGTCGTCGC 120

AGCATTGTCC AGATAGACCA GAGGTTCATC ATTGACAATC TGATCTAAAA TTGGAAAATC 180

CTTGCGAATC GCTTCTACAT CTAACATAGG CTTCCCCTTA GCGTTTTGAC AATTTCTCTT 240

CGATAGTTGC AATCATTTCA TCACGAACTT CCTTGACTGG AATCTCCACG A AACAGATC 300

CAAGGAAACC ACGAACAACC AAACGCTCTG CAGTTGCCTT ATCCAATCCA CGACTCATGA 360

GGTAATACAT GTCTTCTGGA TCAACTTGTC CGATAGACGC TGCGTGTCCT GCAGTGACAT 420

CATTTTCATC AATCAAAAGA ATTGGGTTAG CATCTGAACG CGCTTGGTCT GAAAGCATGA 480

GAACACGGCT CTCTTGTTGC GCATCTGCTC CCTTAGCACC CTTGATGATG TGGCCGATAC 540

CATTGAAAGT CAAAGTTGCT TTTTCAAGGA TAACCCCATG TTGTAGGATA TTTCCGATAG 600

AGTTGCAGCC ATAGTTAGTT ACACGAGTAT CAATCCCTTG TACCTGACGA CCACTTGAAA 660

GAG 663

(2) INFORMATION FOR SEQ ID NO:16:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 649 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:16:

CTAGTTGGAT GGCTTCAATA AAGGATGATT TGGCTGCTCC ACTATTGGCA ATGAGCTGAA 60

AACAGATATA TTCCATTTCT TCGTCATCTT ATTTCTCCTA TCCATTCAAG TGCTTGTTCC 120

AGAACTTTTG CTCCATTCAT CATTCCGTAA TCCCGCATAT CAATGGTATC TACAGGGATA 180

TTTCCTGCAA TTTCTTTCAC AGCAAGTAAC TCATAACGAA TTTGTGGCCC AATTAGAATG 240

ACATCTGCTT CATGGATATT CTTTTTAGCT TCTGTCATTG ATTTTGCTTG GATAGAAATT 300

TCAATCCCAC GTTCAGTCGC ACTTTGTTGC ATTTTTTTAA CAAGCATACT TGTCGACATT 360

CCCGCATTAC ATACTAATAA AATTTGTTTC ATAATCTTAA CCTTCCATTT CTTGTTCAAC 420

AACTTTGTCA TTAACTTTGA TAAATGGAAT GTATAGAAGA ACTCCAAGTG CAAAGATGAT 480 GAATTGAACT AGAACTGCTC TCACGTCCCC TGCTGTTGCT AACCATGCAT TTAAGAATAC 540

TGGTGTAGTC CAAGGAACTT GTATAAATGC AGGACTCATG AATCCTGTAA CTGTTGCTAA 600

GTAGCTGATT AAAATACCAA GGACTGGAAC TGTGATAAAT GGAATAGTC 649

(2) INFORMATION FOR SEQ ID NO: 17:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 497 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:17:

CTTGGTATTA TTTGAAATCA GATGGTTCTT ATGCAAAAAA TGCATGGCAA GGAGCTTATT 60

ACCTTAAATC AAACGGTAAA ATGGTACAAG GTGAGTGGGT TTATGATTCT TCTTACCAAG 120

CCATGGTATT ACTTGAAATC AGATGGTTCA TATGCTCGCA ATGCATGGCA AGGAAACTAC 180

TATTTGAAAT CAGATGGTAA AATGGCTGTC AATGAATGGG TTTATGATGC CACCTATCAA 240

GCATGGTATT ATTTGACATC AGATGGTTCT TATGCTTACA GTACATGGCA AGGAAATTAC 300

TATCCTAAAA TCGGATGGTA AAATGGCTGT CAATGAATGG GTTGATGGTG GACGTTATTA 360

TGTTGGCGCT GACGGAGTTT GGAAGGAAGG TCAAGCAAGT ACAGCTTCTC CTAGTAATGA 420

TAGCAATAGT GAATATTCCT GCTGCTTTAG GAAAGGCAAA AAGTTATAAT TCGTTATTCC 480

ACATGTCAAA AAAAACG 497

(2) INFORMATION FOR SEQ ID NO: 18:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1282 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:18:

CTAGTCTAAA TTTTTTAAAA CAAAGGTCAA AGATAGTCAA TATCAGTAAT CATAACTAAG 60

TAAACAAAAA GAGGTAAAGA ATATGAATAA CAACTTTAAT AATTTTAATA ACATGGATGA 120

TTTATTTAAC CAATTGATGG GTGGTATGCG AGGATACAGT TCTGAAAATC GCCGTTACTT 180

AATTAATGGA CGCGAAGTCA CACCTGAGGA ATTTGCTCAC TATCGTACGA CTGGTCAATT 240

ACCAGGAAAT GCAGAAACTG ATGTGCAAAT GCCACAACAG GCATCAGGTA TGAAACAAGA 300

CGGTGTCCTT GCAAAACTAG GTCGAAACTT GAC GCAGAA GCGCGTGAGG GCAAGTTGGA 360 TCCTGTTATC GGACGAAACA AGGAAATTCA AGAAACATCT GAAATCCTCT CACGCCGCAC 4 0

CAAGAACAAT CCTGTTTTGG TCGGAGATGC AGGTGTTGGT AAGACAGCAG TTGTCGAAGG 480

TCTAGCGCAA GCCATTGTGA ACGGAGATGT TCCTGCTGCT ATCAAGAACA AGGAAATTAT 540

TTCTATTGAT ATCTCAGGTC TTGAGGCTGG TACTCAATAC CGTGGTAGCT TTGAAGAAAA 600

TGTCCAAAAC TTAGTCAATG AAGTGAAAGA AGCAGGGAAT ATTATCCTCT TCTTTGATGA 660

AATTCACCAA ATTCTTGGTG CTGGTAGCAC TTGTGGAGAC AGTGGTTCTA AAGGGCTTGC 720

GGATATTCTC AGCCAATCGA TCTCTCTCGT GGAGAATTGA CAGTGATTGG GGCAACAACT 780

CAAGACGAAT ACCGTAACAC CATCTTGAAG AATGCTGCTC TTGCTCGTCG TTTCAACGAA 840

GTGAAGGTCA ATGCTCCTTC AGCAGAGAAT ACTTTTAAAA TTCTTCAAGG CATTCGTGAC 900

CTCTATCAAC AACACCACAA TGTCATCTTG CCAGACGAAG TCTTGAAAGC AGCGGTGGAT 960

TATTCTGTTC AA ACATTCC TCAACGTAGC TTGCCAGATA AGGCTATTGA CCTTGTCGAT 1020

GTAACGGCTG CTCACTTGGC GGCTCAACAT CCAGTAACAG ATGTGCATGC TGTTGAACGA 1080

GAAATCGAAA CGGAAAAAGA CAAGCAAGAA AAAGCAGTTG AAGCAGAAGA TTTTGAAGCA 1140

GCTCTAAACT ATAAAACACG CATTGCAGAA TTGGAAAGGA AAATCGAAAA CCACACAGAA 1200

GATATGAAAG TGACTGCAAG TGTCAACGAT GTGGCTGAAT CTGTGGAACG AATGACAGGT 1260

ATCCCAGTAT CGCAAATGGG AG 1282

(2) INFORMATION FOR SEQ ID NO:19:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 828 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:19:

CTTGATATAA TTCTTGTTTC GAAAGATTCT CCTTAGGTAT ATCTATTCCT CCACTAGTAA 60

ACGGTAATTC CAAAACAGAG TTTACTTCGT TAAATGTAAG CCAATATTTA ACTTTATCTT 120

TATACCTTTC TAAAACTGTT CGAGCAAATT TTTCATAAAA ATGAATCATT CTTCCTATCA 180

ATCCATCCAT GATATTTTCT TGCTAAATAT AATGGAGTCT CATAGTGTGA AAGAGTTACA 240

AGTGGTTCTA TCCCGTGAGC ATGTAGTTCA TCAAACAATT CATCATAATA TTTCAATCCA 300

GCTTCGTTAG GTTCTTCCTC ATCTCCTTTT GGAAAAATTC TACTCCATGC AATAGAAGTA 360

CGAAAAACAT TAAAGCCCAT TTCAGAAAAC AAGGATATAT CTTCCTTATA TTTATGATAA 420

AAATCAATAC CTATCAATTT TAAGTTATCT TCTGTAGGAT TTTCTGTTGC TTCTCCTAAT 480

CCACCTTTGG GTAACACATC CTGAACTGAT AAGCCCTTAC CATCTTCATT ATATGCTCCC 540

TCTACTTGAT TAGCTGCAAC AGCTCCACCC CAAAGAAAAT CATCTGGAAA AATGGTCATA 600

ACTTTCCTCC ATTATAATAT TACCAGTAAT TCCTTAGAAA TGCTCGATTG TCTGATTATT 660

AGGTAATATT AATACATCTA GAAAATCATT GGTATTCGTT ACAATTACTG GTGTAACTGT 720

TTCGTAGCCT TTAGTCTTGA TTAAATTCAA GTCCATTTCA AAAATCAACT GATTTTTGAA 780

AACTCTGTCT CCTTCTTCTA CATGACTAAT AAAACCTTGA CCTTTTAG 828 (2) INFORMATION FOR SEQ ID NO:20:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1466 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:20:

AGCTATGGTC AGACTCAGAT TGATGGCGTT GCTTATGCCA AGTACGATAT CTTCCGTTTA 60

AAGAACGGGA AAATTGTGGA GCATTGGGAT AATAAGGAAG TCATGCCTAA GGTAGAAGAC 120

TTGACCAATC GAGGGAAGTT TTAAATTGAG GACAAAGAAT GATTGAATAC AAAAATGTAG 180

CACTGCGCTA CACAGAAAAG GATGTCTTGA GAGATGTCAA CTTACAGATT GAGGATGGGG 240

AATTTATGGT TTTAGTAGGG CCTTCTGGGT CAGGTAAGAC GACCATGCTC AAGATGATTA 300

ACCGTCTTTT GGAACCAACT GATGGAAATA TTTATATGGA TGGGAAGCGC ATCAAAGACT 360

ATGATGAGCG TGAACTTCGT CTTTCTACTG GTTATGTTTT ACAGGCTATT GCTCTTTTTC 420

CAAATCTAAC AGTTGCGGAA AATATTGCTC TCATTCCTGA AATGAAGGGG TGGAGCAAGG 480

AAGAAATTAC GAAGAAAACA GAAGAACTTT TGGCTAAGGT TGGTTTACCA GTAGCCGAGT 540

ATGGGCATCG CTTACCTAGT GAATTATCTG GTGGAGAACA GCAACGGGTC GGTATTGTCC 600

GAGCTATGAT TGGTCAGCCC AAGATTTTCC TCATGGATGA ACCCTTTTCG GCCTTGGATG 660

CTATTTCGAG AAAACAGTTG CAGGTTCTGA CAAAAGAATT GCATAAAGAG TTTGGGATGA 720

CAACGATTTT TGTAACCCAT GATACGGATG AAGCCTTGAA GTTGGCGGAC CGTATTGCTG 780

TCTTGCAGGA TGGAGAAATT CGCCAGGTAG CGAATCCCGA GACAATTTTA AAAGTGCCTG 840

CAACAGACTT TGTAGCAGAC TTGTTTGGAG GTAGTGTTCA TGACTAATTT AATTGCAACT 900

TTTCAGGATC GTTTTAGTGA TTGGTTGACA GCTACAATGA CATTGGTCGG TTCCTTGAGC 960

AAGAGATAGA TTAGCCAGAC AGTCATGCCC AAAATCCCTC CAGGTAAGAG CATAGACCGT 1020

TGCACATTAA GTACGATTAA AAAAGTGATA ATGGCAAGAA AACTTGCTAC TGCTTGTAAT 1080

AAAAAGGTTG TTAGTGTCAT ATTAGTTCAT CAATACCAAG GCGACAGAAG TTCCTGCCCC 1140

TAAAGCGAGG GTAATGAGCA GGGATTCAAA CATCTTACTC ATACCAGAGT TTATGTGGTT 1200

GGTCATAATA TCACGGACCG CATTGGTCAA GGCAATACCT GGTACAAACG GCATGACCGC 1260

ACCAGCTATA ATCAAATCCT GCCCGTTTGA ATGGAAAAAC CCTGTGTTAG CCGAGCCCCA 1320

AAACTGGGGC CAATTTATCC CCCAAAGACA AAAGCTCCAT CAAAGGCTGT CACAAAGGGA 1380

ATTCGGATAA ATTTTCCACA TAGAAGGAAA AGGCAAAACC AAATAAGGTC GCCACTCCTG 1440

CCCCAAGTGC TCGTAAATAT TCCGCT 1466

(2) INFORMATION FOR SEQ ID NO: 21:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:21:

AAGGTTCTTC GTAAATGTAC ACCATTCGGA TGCTCAAAAT GGGTTCTGAA GCTGCTGCTA 60

AATCTGCACA AGAACACGGT CTTAAATCAG TTGAAGTTAC TGTAAAAGGT CCAGGTTCTG 120

GTCGTGAGTC AGCTATTTCG TGCGCTTGCT GCCGCTGGTC TTGAAGTAAC AGCAATTCGT 180

GATGGGACTC CAGTGCCAAC ACAATGGTGC TTCGTCCTCC AAAACGTCGC CGTGTATAAT 240

CATCGCATTA CACTGCTTTT CGTTTAAGAG GGAGTAACTA AATGATCGAG TTTGAAAAAC 300

CAAATATAAC AAAAATTGAT GAAAATAAAG ATTATGGCAA GTTAGTAATC GAACCACTTG 360

AACGTGGCTA CGGTACAGCT CTTGGTAACT CTCTTCGTCG TGTACTTCTA GCTTCTCTAC 420

CAGGAGCAGC TGTGACATCT ATCAACATTG ATGGTGTGTT ACATGAGTTT GACACAGTTC 480

CAGGTGTTCG TGAAGACGTG ATGCAAATCA TTCTGAACAT TAAAGGAATT GCAGTGAAAT 540

CGTACGTTGA AGACGAAAAA ATCATCGAAC TGGATGTTGA AGGTCCTGCT GAAGTAACAG 600

CTGGTGACAT TTTGACAGAT AGCGATATTG AAATTGTAAA TCCAGATCAT TATCTCTTTA 660

CAATTGGTGA AGGTTCTTCT CTAAAAGCGA CTATGACTGT TAACAGTGGT CGTGGATATG 720

TACCTGCTGA TGAAAATAAA AAGGATAATG CACCAGTTGG AACACTTGCT GTAGATTCTA 780

TTTATACACC AGTTACAAAA GTCAACTATC AAGTGGAACC TGCTCGTGTA GGTAGCAATG 840

ATGGTTTCGA CAAATTAACC CTTGAAATCT TGACAAATGG AACAATTATT CCAGAAGATG 900

CTTTAGGGCT TTCAGCACGT ATTTTGACAG AACATCTTGA TTTGTTTACA AATCTTACTG 960

AGATTGCTAA GTCAACTGAA GTGATGAAAG AAGCTGATAC TGAATCTGAC GACCGTATTT 1020

TAGATCGTAC GATTGAGGAA CTGGACTTGT CTGTGCGTTC ATACAACTGT TTAAAACGTG 1080

CCGGTATCAA TACTGTGCAT GATTTGACAG AAAAATCTGA AGCAGAGATG ATGAAAGTAC 1140

GAAATCTTGG ACGCAAGAGT TTGGAAGAAG TGAAACTCAA ACTCATTGAT TTGGGTCTTG 1200

GATTAAAAGA TAAATAAAGG AGGAATACAT GGCTTACCGT AAACTAGGAC GCACTAG 1257

(2) INFORMATION FOR SEQ ID NO:22:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1332 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:

CTATTGAAAC AAGAAAAATA GAGAATCAAA GAAAGAGAAC TTATGAATAT TCAAGAAGAA 60

ATTAAGAAAC GTCGTACCTT TGCCATTATC TCCCACCCGG ACGCGGGGAA AACAACCATC 120

ACTGAGCAGT TACTCTAACT TTGGGGGTGA GATTCGTGAG GCTGGTACGG TAAAAGGGAA 180

GAAAACAGGG ACTTTTGCTA AATCTGACTG GATGGATATC GAGAAGCAAC GTGGGATTTC 240 TGTTACTTCA TCTGTTATGC AATTTGACTA CGACGGCAAG CGCGTGAATA TCTTAGACAC 300

GCCAGGGCAC GAGGACTTCT CAGAAGATAC CTATCGTACC TTGATGGCGG TGGATGCTGC 360

GGTCATGGTC GTGGACTCTG CCAAGGGGAT CGAGGCTCAA ACAAAGAAAT TGTTTGAGGT 420

TGTGAAACAT CGTGGCATTC CAGTCTTTAC CTTTATGAAC AAGTTGGATC GTGACGGTCG 480

TGAGCCTTTG GATCTCTTGC AAGAATTGGA AGAAATCTTG GGCATTGCTA GCTACCCTAT 540

GAACTGGCCT ATCGGGATGG GGAAAGCCTT TGAGGGCTTG TATGACCTCT ATAACCAACG 600

TTTAGAGCTT TACAAAGGGG ATGAGCGTTT TGCTAGCCCT AGAAGATGGA GACAAACTTT 660

TTGGTAGCAA TCCTTTCTAC GAGCAAGTCA AGGATGACAT TGAGCTTTTA AATGAAGCTG 720

GGAATGAGTT TTCAGAGGAA GCTATTCTGG CTGGAGAATT GACGCCTGTC TTTTTCGGTT 780

CAGCCCTGAC AAACTTTGGT GTGCAGACCT TCCTTGAAAT CTTCCTCAAG TTTGCTCCAG 840

AACCACATGG TCACAAGAAA ACAGACGGTG AAATTGTGGA TCCTTATGAC AAGGATTTCT 900

CAGGCTTTGT CTTTAAAATC CAAGCCAACA TGGATCCTCG TCACCGTGAC CGTATTGCCT 960

TTGTCCGTAT CGTATCAGGC GAATTTGAGC GTGGCATGAG TGTCAATCTC CCTCGTACTG 1020

GTAAGGGTGC CAAACTATCT AATGTTACCC AGTTTATGGC GGAGAGTCGT GAGAATGTGA 1080

CCAATGCCGT AGCAGGTGAT ATTATCGGGG TTTACGATAC CGGTACTTAT CAGGTTGGGG 1140

ATACCTTGAC GGTTGGAAAA AACAAGTTTG AATTTGAACC ACTGCCAACC TTTACTCCTG 1200

AAATTTTCAT GAAAGTTTCT GCTAAGAATG TTATGAAGCA AAAATCCTTC CACAAGGGGA 1260

TTGAGCAATT GGTGCAAGAA GGAGCCGTTC AGCTTTATAA GAATTACCAA ACAGGTGAGT 1320

ACATGCTGGG AG 1332

(2) INFORMATION FOR SEQ ID N0:23:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 932 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 23:

TTGGACGCTG GAACAAATCC AAGCTGACCT GTTCCAAGAC CAGACTTGGT ATGCTCTGGC 60

TTATGATGGG GCAGAAGTGA TTGGCTTTCT AGCTGTTCAG GAGACTCTTC TTTGAAGCAG 120

AAGTCCTGCA AATCGCTGTC AAAGGAGCCT ATCAGGGTAA GGGCATTGCG TCAGCCTTGT 180

TTGCTCAATT GCCGACAGAC AAGGAAATTT TCCTCGAAGT CAGACAGTCA AATCAACGAG 240

CGCAAGCATT TTACAAGAAA GAAAAGATGG CAGTTATCGC TGAGCGAAAG GCCTACTACC 300

ATGACCCAGT CGAGGACGCC ATTATCATGA AGAGAGAAAT AGATGAAGGA TAGATATATT 360

TTAGCATTTG AGACATCCTG TGATGAGACC AGTGTCGCCG TCTTGAAAAA CGACGATGAG 420

CTCTTGTCCA ATGTCATTGC TAGTCAAATT GAGAGTCACA AACGTTTTGG TGGCGTAGTG 480

CCCGAAGTAG CCAGTCGTCA CCATGTCGAG GTCATTACAG CCTGTATCGA GGAGGCATTG 540

GCAGAAGCAG GGATTACCGA AGAGGACGTG ACAGCTGTTG CGGTTACCTA CGGACCAGGC 600

TTGGTCGGAG CCTTGCTAGT TGGTTTGTCA GCCGCCAAGG CCTTTGCTTG GGCTCACGGA 660

CTTCCACTGA TTCCTGTTAA TCACATGGCT GGGCACCTCA TGGCAGCTCA GAGTGTGGAG 720 CCTTTGGAGT TTCCCTTGCT AGCCCTTTTA GTCAGTGGTG GGCACACAGA GTTGGTCTAT 780

GTTTCTGAGG CTGGCGATTA CAAGATTGTT GGAGAGACAC GAGACGATGC AGTTGGGGAG 840

GCTTATGACA AGGTCGGTCG TGTCATGGGC TTGACCTATC CTGCAGGTCG TGAGATTGAC 900

GAGCTGGCTC NTCTNGGGCA GGANATTTAT GA 932

(2) INFORMATION FOR SEQ ID NO:24:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1158 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:24:

CTAAACTTTC GCTCATAGGC ATACAAATTA ATCCTTTGGC ATAAGTAGCC ATAAAATTAA 60

CATTTTCTGT TGTAGCTGCT TGTGCAGAAC AAATTAAGTC TCCTTCATTT TCTCTATCCT 120

TGTCGTCTAT AACAAGAACA AGTCGTCCCT TCTGCAATGC TTCTAATGCT TCTTGTATTT 180

TTCGATATTC CATTGACTGA TTATCCTTTC TGCTAAAATC CATTTTGATA TAATAGTTCC 240

TTCGATATTT CTGATTTTGG AGAGTTATCC ATCAGTTTTT GCACATATTT ACCTAAGATA 300

TCATTTTCAA GATTTACTGT ACTCCCGACT TGTTTACTCT TAAGAATGGT TTGTTTCAAG 360

GTATGAGGGA TAACAGATAC TGAAAAGTTT ACTTTGGAGA CTTTAGCGAC AGTCAGACTA 420

ATGCCGTCAA TTGTAATAGA TCCTTTTTCA ACTATTAAAT CTAAAATTTC TTTTTGTGTG 480

TTGATTTGAT ACCATACAGC ATTATCATCT TTTTTTATTG ACGAGATTTT TCCTGTACCA 540

TCAATGTGTC CTGTAACGAC GTGACCCCCA AGTCGACCGT TGACAGATAA GGCTCTTTCT 600

AGATTCACCT CACTTCCATG TTTTAATAGA GTAAGAGCTG TTCGACTCCA TGTTTCATTC 660

ATTACATCAA CTGTAAAGGA TTGATGATTG AAATGAGTAA CTGTAAGACA GATACCATTT 720

ACTGCTATAC TATCGCCTAA ATGGATATCC GTTAATATTT TTGAGGCTTT AATTGATAGT 780

TTACAATTAC GAGAGTCTTT CTGTATTCCT TCAACTTTTC CGATTTCTTC AATTATTCCT 840

GTGAACATGG ATAAATCACT TCACTTTCTA TGAGATAGTC NTTTCCTNTT TGAGAAAAAG 900

CATAAGGTTT CAATCTAATA GCGTCATTTG GCAAAGAAAT GCCTTCACCT CCGACAGGAA 960

ACTTGGCACT GCCTCCAAAA ATTTTTGGTG CAATATATAT TTTCAGCTCA TCAACAATTT 1020

GTTGTTCCAA AGCACTCCAA TTCATTAGAC TGCCCCCCTC TACAACTAGG CTATCAATCT 1080

GCATGTTTCC TTAGATGTTN GCATTAAACT CNGATAAGTC TATATGATTG CCTTTTTTCT 1140

TTATGGAAAG TATTCCCC 1158

(2) INFORMATION FOR SEQ ID NO:25:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1482 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:

TAAAGGCTGT TTGGATAATG TAACATAAAG AAATCTTGTT TAGCAGGGAT TGAATAGAGT 60

TCCTGAAGTG ATGACTTCTT TATTAGACAT AATGTCTGGA CCCAAGATTA AAAGAATGGC 120

CCCGAAGAAT ACGAGCATCA AAGGTAGCAG ATGCAACAAC TGTATCGTGG AAGATTGAGA 180

GGAACTTAGG TAATTTAAGA TTGTCTAAAC TTTCTTCTTT CTTACCAAAG CGTCCTGCTA 240

CTTTATCTAC AAACCAGATT GCAAATTGCT GTTGGTGACC AATCGCAAAT CCGCCACCAC 300

CAGTCAAGCG TTGAGTTGCC TCAACAGTCA TATTTGAACT AACTGCCCAG TAAAGTCCAC 360

AGATGATACC AATCGCTGCT GTACCGTAAG CATTGCGCAA TTGTGGTACT AAGAATAGAA 420

CCATAAGAGA TACTGTTGCA GCTAGCCATG CTGATCAATT CCCTCAACCA GTCCTATATC 480

TCAGCCAAGA GAATCGAGGA GGTCTTTGCG GAATCTCCCG AAAACATCCA TTCAGAATTA 540

GAACAAAAGC AAGTTACCAG TGGTCGGGTT TTACAAGTCC AAGAATTGAC TTTTACCTAT 600

CCTGATGCGG CCCAGCCTTC TCTGAGAGAC ATTTCCTTTG ATATGACTCA AGGACAAATC 660

CTTGGTATCA TTGGGGGGAC TGGTTCTGGT AAATCAAGCT TGGTGCAACT CTTACTTGGA 720

CTTTATCCAG TAGACAAGGG GAACATTGAC CTTTATCAAA ATGGACGTAG TCCTCTTAAT 780

TTGGAGCAGT GGCGGTCTTG GATTGCCTAT GTACCTCAAA AGGTCAAACT CTTTAAGGGA 840

ACTATTCGTT CCAACTTGAC TTTAGGTTTA AATCAAGAAG TATCTGACCA GAAACTCTGG 900

CAGGCCTTGG AGATTGCGCA AGCTAAGGAT TTTGTCAGTG AAAAGGAAGG ACTTTTGGAT 960

GCCCTAATTG AAGCAGGGGG GCGAAATTTC TCAGGTGGAC AAAAACAAAG GTTGTCTATC 1020

GCCCGAGCAG TCTTGCGCCA AGCTCCGTTT ATCATCCTAG ATGATGCAAC CTCGGCACTG 1080

GATACCATTA CAGAGTCCAA GCTCTTGAAA GCTATTAGAG AAAATTTTCC AAACACGAGC 1140

TTAATTTTGA TCTCTCAACG AACCTCAACT TTACAGATGG CGGACCAGAT TCTCCTCTTG 1200

GAAAAAGGTG AGTTGCTAGC TGTTGGCAAG CACGATGACT TGATGAAATC CAGCCAAGTC 1260

TATCGTGAAA TCAATGCATC CCAACATGGA AAGGAGGACT AGAATGAAAC GACAAACTGT 1320

AAACCAGACG CTCAAACGTT TAGCCGTAGA TTTAGCAAAC CATCCCTTCC TCCTTTTCCT 1380

AGCCTTTCTA GGAACTATTG CCCAAGTTGG CTTATCAATT TACCTACCTA TTCTGATTGG 1440

GCAGGTCATT GACCAAGTCC TAGTGGCTGG TTCATCACCA GT 1482

(2) INFORMATION FOR SEQ ID NO:26:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 895 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26: CTCTGAAGGA TCCAGAAAGT CGCTTATATA TTTTATTAAA AGACGGTCAG GTTATTGGGA 60

CTTGTACGGT TGATTTATCG ACTAATACGA ATTACTTCTA CGGTTTAGCA ATATTGGAAC 120

CTGAACGTGG AAAAGGCTAT GGAAGCTACT TAGCAAAATC CCTCGTCAAC CAACTAATTG 180

AGCAAAATGA CAAGGAATTT CAGATTGCAG TGGAAGATAG CAATGTAGGT GCCAAACGTT 2 0

TGTATGAAAA AATTGGCTTT GTCAAACAGA CTCAGGTGGT TTATCTGAAT GAGAAAGGAG 300

CAAGGGATTC CGAAGTGTAG AGATATTCGG ACTGAAATTT ACTTGAACTT TTAGTGATGA 360

AACTAATTGT TCTTGGATTT CAGCTTTCCT GATTATGATT TATGATTAAA ATCTATGACA 420

CCATGTCTCG TGATTTGCGA GAATTTGTCC CGATTGAGGA CGGCAAGATC AAGATGTATG 480

TTTGTGGGCC AACGGTGTAC AACTATATCC ACGTGGGAAA CGCCCGTTCG ACGGTAGCTT 540

TTTTGGATAC GAATTTCGTC GCTATTTTGA GTACCGTGGG TATAAGGTTG CCTATATTTC 600

CAATTTTACA GATGTGGATG ATAAGATTAT CAACCGTGCC AGGGAAGAAG GCATCACGCC 660

TCAGGAGGTT GCGGATAAGT ACATCGCTGC CTTTCGTGAG GATGTGACGG CCTTGGGCGT 720

GAAACCTGCG ACTCGCCATC CGCGTGTAGT GGAGTTTATG GCAGACATCA TCCGTTTTGT 780

GGAAGACTTG ATCGAGAAAG GCTTTGCCTA TGAGAGTCAA GGGGATGTCT ATTTCCGTGT 840

AGAAAAATCC CACAACTATG CTAAATTGGC TAATAAAACC TTGGAAGATT TGGAG 895

(2) INFORMATION FOR SEQ ID NO:27:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 709 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27:

CTGTTTGCCC TTTCTTCTAA TAAAGAATTG GCAGAACGTG TGGCGCAGGA GATTGGGATA 60

GAGTTGGGGA AATCAAGTGT TCGCCAATTT TCAGATGGAG AGATTCAGGT CAACATTGAA 120

GAATCAATCC GTGGGAAACA CGTCTTTATC CTACAATCAA CTAGTTCGCC TGTAAATGAC 180

AATCTGCTTG AAATTTTGAT TATGGTAGAT GCTTTGAAGC GTGCGAGTGC AGAATCTGTC 240

AATGTTGTCA TGCCTTACTA TGGGTATGCA CGTCAGGATA GAAAGGCGAG AGCGCGTGAG 300

CCAATCACTT CAAAACTTGT CGCAAATATG CTTGAAGTAG CTGGAGTGGA TCGTTTATTG 360

ACCATCGACT TGCATGCTGC GCAAATTCAA GGATTCTTTG ATATTCCTGT GGATCATTTG 420

ATGGGTGCTC CTCTGATTGC AGATTATTTT GAGCGTCCTG GTATGGTTGG TTCTGACTAT 480

GTGGTTGTCA GCCCGGACCA TGGAGGGGTG ACTCGTGCTC GTAAGTTGGC AGAATTTTTG 540

AAAACATCTA TCGCTATTAT TGAGAAACGT CGTAGCGTTG ATAAGATGAA TACTAGTGAA 600

GTTATGAACA CCATCGGTAA GGTTGAAGGC AACCACTTGT AGCTTCGATT GATGATATGT 660

ATTGATACCG CTGGAACGAT TTGTCATGCG GCAGATGCTC TTGCGGAAG 709

(2) INFORMATION FOR SEQ ID NO:28:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 816 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:28:

CTAGAAGAAC TCCGTCACAA GCTTGTGACT TGTAAGCAAG AACAGAGCAA GATTGAGGAT 60

TCCTTATGAT TTCATTCCTT CTTCTATTGG TCTTGGTTTG GGGATTTTAT ATCGGCTATC 120

GGAGAGGCCT GCTCTTACAG GTTTATTACC TGATTTCAGC CATGGCATCG GCTTTTATGG 180

CTGGCCAGTT TTATAAGGGG CT GGAGAGC AATTCCATTT ATTGCTCCCT TATGCAAATT 240

CGCAGGAAGG TCAGGGGACT TTCTTTTTCC CATCGGATCA ACTCTTTCAG CTGGATAAGG 300

TCTTTTATGC AGGTATCGGC TACTTGCTTG TATTTGGGAT TGTCTATAGC ATTGGTCGTT 360

TGCTTGGTCT TCTCTTACAC TTGATTCCTA GCAAAAAACT GGGTGGTAAG TTGTTCCAAG 420

TTTCAGCAGG TATCTTGTCC ATGTTGGTGA CCTTATTTGT CTTGCAAATG GCCTTGACAA 480

TCTTGGCGAC CATCCCCATG GCAGTTATAC AAAATCCTCT TGAAAAGAGT ATCGTCGCAA 540

AACACATCAT CCAGAGCATA CCGATAACAA CCAGTTGGCT CAAACAAATC TGGGTGACAA 600

ATTTAATCGG ATAAAAAGGG CAGGAGTTTT CCTAGCCCTT TGTTTACAGA TTTGACTCGA 660

ATCTATCAGA ATGTAAAAAG CTACCACACC TAGACATTCA AAGACAAGGA AATAAAGATG 720

AATAAGAAAA TATTAGAAAC ATTAGAGTTC GATAAGGTCA AGGCCTTGTT TGAGCCTCAT 780

TTGTTGACCG AGCAGGGCTT GGAGCAATTG AGACAG 816

(2) INFORMATION FOR SEQ ID NO:29:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1001 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:

CTTGAAGCAG CTGAAAGCAT GGGGTCTTCG GGATTTAAAA CCTATTCGTA ACGGGTTGTT 60

TTACCTTTCC TAGTTCCAAC CTTACTAGCA GCTCCTTGCT TGTATTTATG AGAGCATTCT 120

CAGACTTTGG AACGCCTATG TTGATTGGCG AAGGATATCG GACTTTCCCT GTCCTGATTT 180

ATACCCAATT TATTAGCGAG GTTGGAGGAA ATTCTGCTTT TGCAATTATG GCGATTATCA 240

TTGCCTTGGC AATTTTCCTT ATCCAAAAAC ACATTGCAAA CCGCTACAGT TTCAGCATGA 300

ATCTGCTCCA TCCAATTGAG CCTAAAAAAA CTACAAAAGG AAAAATGGCT GCCATTTATG 360

CAACAGTCTA CGGAAT ATC TTT TCTCTG TTTTACCTCA AATCTACTTA ATTT TACCT 420

CTTTCCTAAA AACATCAGGT ATGGTATTTG TTAAAGGTTA TTCTCCAAAC AGTTACAAGG 480 TAGCTTTCAA TCGTATGGGA TCTGCTATTT TCAATACCAT TCGTATCCCT TTGATTGCCT 540

TAGTTCTAGT TGTTCCTATT TACGACATTT ATCTCCTACC TAGCCGTTAG AAAACGGAAT 600

TTGTTTACAA ACTTAATTGA CAGCCTCAGT ATGGTACCTT ATATTGTACC AGGAACCGTT 660

CTAGGGATTG CCTTCATTTC TTCCTTCAAT ACTGGTCTAT TTGGAAGTGG ATTTCTTATG 720

ATTACAGGGA CTGCTTTCAT CTTGATTATG TCTCTATCTG TCAGAAGATT ACCGTATACT 780

ATTCGCTCAT CTGTTGCTAG CTTACAACAA ATAGCACCAA GTATTGAAGA AGCTGCTGGA 840

AAGCTTAGGA AGTAGTCGTC TCAATACCTT TGCTAAGATT ACAACTCCAA TGATGCTATC 900

TGGTATCATT TCTGGAGCCA TCTTATCTTG GGTCACAATG ATTTCAAAAC TCTCTACTTC 960

TATCCTCCTC TACAATGTCA AAACAAGAAC AATGACTGTA G 1001

(2) INFORMATION FOR SEQ ID NO:30:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1064 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:30:

CTGGTTTGCA ATCTATTCCA ACTGAGATTA CAGAGGCAGC AAGGATTGAT GGTGCGACTA 60

GCAAGCAAGT TTTCTGGAAC ATTGAATTGC CTTACTTGCT ACCAAGTGTC TCTATGGTCT 120

TTATCCTAGC CCTAAAAGGT GGGCTGACTG CCTTTGACCA AGTCTTTGCC ATGACCGGTG 180

GTGGTCCAAA CAATGCCACA ACCTCACTTG GGCTCTTGGT TTATAACTAT GCCTTTAAAA 240

ACAACCAATT CGGTTATGCC AATGCCATTG CCGTAATCTT GTTCCTCTTA ATTGTAGTGA 300

TTTCGATCAT CCAATTGAGA GTATCTAAGA AATTTGAAAT TTAAGAGGAG AAGCATGATG 360

AAACAAGATG AAAGAAAAGC CCTGATTGGC AAATACATTC TATTGATTCT AGGATCGGTT 420

CTGATTTTAG TGCCGCTCCT TGCTACCCTC TTTAGTTCCT TTAAACCCAC TAAGGATATT 480

GTAGATAATT TCTTTGGCTT TCCAACCAAC TTCACATGGG ACAACTTTAG CCGTCTCTTA 540

GCTGATGGGA TTGGAGGCTA TTATTGGACT CTGTCGTCAT CACTGTCTTG TCTTTACTTG 600

CAGTAATGAT CTTTATCCCT ATGGCAGCCT ACTCCATCGC TCGCAATATG AGTAAAAGAA 660

AAGCCTTTAC CATTCATGTA TACCCTCTTA ATCCTCGGAA TCTTCGTACC TTTCCAAGTC 720

ATCATGATTC CGATTACGGT TATGATGAGT AAACTCGGTT TGGCTAATAC CTTTGGTTTG 780

ATCTTGCTCT ACTTGACCTA TGCGATTCCA CAGACCCTCT TTCTCTATGT TGGATATATC 840

AAAATCTCGA TTCCAGAAAG TCTGGATGAA GCAGCAGAGA TCGATGGGGC TAATCAATTT 900

ACAACCTATT TCCGCATCAT NTTCCCAATG ATGAAACCGA TGCATGCGAC AACCATGATC 960

ATCAATGCCC TTTGGTTCTG GAATGACTTC ATGTTGCCAC TCCTTGTCTT GAACCGGGAT 1020

TCCAAAATGT GGACTCTGCC TTTGTTCCAA TACAACTACG CAGG 1064

(2) INFORMATION FOR SEQ ID NO: 31:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 586 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31:

CTGTAAAAGA AGTTAATCAA GTTGATAAAG CACTTTTAAA ACAAATTGGT GCAGTTGATG 60

TCTTAGAAGT GAAGGGTGGC ATTCAAGCAA TCTATGGAGC AAAAGCAATC TTATATAAAA 120

ATAGTATTAA TGAAATTTTA GGTGTAGATG ATTAAGTACT TACTGACTTA ATAAAAAACA 180

GAGGAGAGTG ATGGATGAGT AGGATGAAAT GAAATCGCAT ACAAGAAATA AAGAACTCAT 240

TATCCAAGTT GGATACGCTT ATTACATAGG AGAATACAAA TGAAATTTAG AAAATTAGCT 300

TGTACAGTAC TTGCGGGTGC TGCGGTTCTT GGTCTTGCTG CTTGTGGCAA TTCTGGCGGA 360

AGTAAAGATG CTGCCAAATC AGGTGGTGAC GGTGCCAAAA CAGAAATCAC TTGGTGGGCA 420

TTCCCAGTAT TTACCCAAGA AAAAACTGGT GACGGTGTTG GAACTTATGA AAAATCAATC 480

ATCCAAGCGT TTTGAAAAAG CAACCCAGAT ATAAAAGTGA AATTGGAAAC CATCCACTTC 540

CAGTCCAGTC CTGAAAAATC ACAACAGCCA TCCGAAGCAG GAACAG 586

(2) INFORMATION FOR SEQ ID NO: 32:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1534 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:32:

TGGTAGTTCT TCCTAGTGCA GGGGCTGTAG ACCCAGTTGC GACCCTAGCG CTGGACTAGT 60

CGAGAGGGTG TTGTTGAAAA TGGATGGNTA TCGCTATGTT GGTTATCTAT CAGGTGACAT 120

CCTCAAAACG CTTGGCTTGG ACACTGTTTT AGAAGAAACC TCAGCAAAAC CTGGAGAGGT 180

GACTGTAGTC GAAGTTGAGA CTCCTCAATC AACAACAAAT CAGGAGCAAG CTAGGACAGA 240

AAACCAAGTA GTAGAGACAG AGGAAGCTCC AAAAGAAGAA GCACCTAAAA CAGAAGAAAG 300

TCCAAAGGAA GAACCAAAAT CGGAGGTAAA ACCTACTGAC GACACCCTTC CTAAAGTAGA 360

AGAGGGGAAA GAAGATTCAG CAGAACCATC TCCAGTTGAA GAAGTAGGTG GAGAAGTTGA 420

GTCAAAACCA GAGGAAAAAG TAGCAGTTAA GCCAGAAAGT CAACCATCAG ACAAACCAGC 480

TGAGGAATCA AAAGTTGAAC CACCAGTAGA ACAAGCAAAA GTCCCAGAAC AACCCGTGCA 540

ACCTACACAA GCTGAGCAAC CAAGTACACC AAAAGAATCA TCACAACAAG AAAATCCTAA 600

AGAAGATAGG GGAGCGGAAG AGACACCGAA ACAAGAAGAT GAACAGCCAG CAGAAGCCCC 660

AAGAAATCAA GGTTGAAGAA CCAGTAGAAT CAAAAGAGGA GACTGTTAAT CAACCTGTTG 720 AACAACCAAA AGTGGAAACG CCTGCTGTAG AAAAACAAAC GGAACCAACA GAGGAACCAA 780

AAGTTGAAGT AACAAGTATT CCCCAAACTA CTCGCTATGA GGAAGACCTT ACTAAGGAAC 840

ACGGAACGCG TGAAGTTGTT AAGGAAGGTA AGAATGGCAG TAGAACAGTT ACTACTCCAT 900

ATATCTTGAA TGCGACAGAT GGTACGACTA CAGAAGGCAC TTCGACAACT GATGAAGCTG 960

AGATGGAGAA AGAGGTTGTT CGTGTTGGCA CGAAACCCAA AGAAAAATTA GCTCCAGTCT 1020

TAAGTTTGAC AAGTGTTACA GATAATGCAA TGTTGCGTAG TGCGAGACTT ACTTATCATT 1080

TGGAAAATAC AGATAGTGTT GATGTGAAAA AAATTCATGC TGAAATTAAA AATGGCGATA 1140

AGGTTGTCAA AACTATTGAC TTATCTAAAG AGAGATTATC AGATGCTGTT GACGGTCTTG 1200

AACTTTATAA AGATTATAAG ATTGTGACGA GTATGACCTA TGATAGAGGT AATGGTGAAG 1260

AAACCTCTAC GTTGGAAGAA ACTCCACTAC GATTAGACCT CAAGAAGGTT GAATTGAAAA 1320

ACATCGGCTC TACTAATCTC GTCAAAGTAA ATGAGGATGG TACTGAGGTG GCAAGTGACT 1380

TCTTAACAAG TAAACCTGTG GATGTGCAGA ATTACTACCT CAAAGTAACT TCCCGTGATA 1440

ATAAAGTTGT TTCCCCTCCC AGTTGAAAAA ATTGAAGAGG TGACTGAGGA AGGTCCACCA 1500

CTTTACAAAG TCCCTGCTAA GGCCCTAATT TGAT 1534

(2) INFORMATION FOR SEQ ID NO:33:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 695 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:

CGGATTTGTT TATCTCAAGA AGAGTCGCGA TATTCTCCGT GAAAGTTCAG AATTGATTAN 60

CCAAACGGTA GAAGATTATC TTCAAGGAGA TGACTTTGAC TGGGCAGATC TTAAAGGGAA 120

GGTTCGANAT AATTTGACCA AGTATCTCTT TGACCAAACC AAGCGTCGTC CANCTATTTT 180

ACCAGTAGTC ATGGAAGCAA AATAATCGTT GAAATAAACA GAGAGAAAGT CGAGTTTCGG 240

CTTTTTCTTA TAGAAAAATA GAAGGAGAAA ATCATGGCAG TAATGAAAAT CGAGTATTAC 300

TCACAAGTAT TGGATATGGA GTGGGGGGTG AATGTCCTCT ACCCTGATGC CAATCGAGTG 360

GAAGAACCAG AGTGTGAAGA TATTCCCGTC TTGTACCTTT TGCACGGGAT GTCTGGAAAT 420

CATAATAGTT GGCTTAAGCG GACCAATGTA GAACGCTTGC TTCGAGGAAC TAATCTC TC 480

GTTGTTATGC CCAATACCAG CAATGGTTGG TACACCGACA CCCAGTATGG TTTTGACTAC 540

TACACGGCTC TAGCAGAGGA ATTGCCACAG GTTCCTGAAA CGCTTCTTCC CTAATATGAC 600

TAGCAAGCGT GAAAAGACCT TTATCGCTGG TCTTTCTATG GGAGGCTACG GCTGCTTCAA 660

ACTGGCTCTT ACGACAAATC GTTTTTCTCA TGCAG 695

(2) INFORMATION FOR SEQ ID NO:34:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1096 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:

CTCATCCAAG AATAGCATAA AAGAACTCTT CTGTTTTTTC TTGAGGAACG AGAAAGTCAG 60

CAATCTCCAT TCCACGATCC ATCAAATCCT CTAAAGACAT CGTGATTTTT AAAGTAGTAT 120

CACTAATTTG TTTCATTTTC ATTGCTAGTA ACCTCATACT TTCAGTTCTA TCTATTATAC 180

TAGATTTTTA CGATTTTATC AAAAGAAGGC TCCTCTATAC GGATAGATTT TCCCTAGGGT 240

CTTTCTATAG GAGACTCCAA GAGAAAATTT CTGCAGACAG ATAGAAAAAG CCTTCAAAAT 300

CGGCTCTTAG CCGATTTTGA AGACCTTATA CATCAGAATA CTTATAATTT AAAGGTTGCT 360

ACACCGAGGA TAGAACGATT TAAGTTTCTG AGAATTTGAA GACTTTGCTC AAATTTCTTA 420

TAACGAATTC ACTCCGTACT CTTCAACAAG AAGGACTGTA TCTCTTTCCA AAAGAGATGA 480

TACATCCTGC AAATCTACAA ATGCATTCCT TTTAAAGCTT CTTGACTCTG TTTCAATTTA 540

TCTAGGATAG CTTTATTTGA GCTAACGATG GTCAATTCCT GTCCAGTATT TTTGTATGAC 600

AAAACATCTG CTAGGTTAGC AATTGTTGTA ATCTCTGTTA CAAAATCAAT TTGATACTGA 660

GAAAAATCAC CTACTCTATT GATTGTTGGA TTAAAGAGAT AAACTAACAC ATTTCCCATC 720

ACAACCAAAA TCACACAAAC CACTCCAATA ACAACTAAAC GAAGAATCAG ATTTTTCACA 780

TTTAAGCCAA GCGCTGTTTC ACCATTTGCG TTCAATTCTT TAGAGTTGAT GGTTTCCAGT 840

TTTTCAATTT TCACATTTGC ATAAGCATGT TTAAATTTCT CAATCAACCC ATCAATTTTT 900

TTCTCTAACA AGTCATTGGC ATCTTTACTT GATGTCAAAA TTTTCACACC AACCCCTGCA 960

TCGTCAATCA TATAGTAGAC GGTCAATTTT TTCCACCAAT AGTCATTCGT TGAATTTTTC 1020

AAGGTTGTTT CCGTCGTGTC TAATTCACTG GCAATTTTTT TCAACTCACT GGGTTCTACA 1080

TCATTGAAAA GATAAG 1096

(2) INFORMATION FOR SEQ ID NO: 35:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1037 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:35:

TCCCCATCCC AGTGGGCAGC AGCATTAGTC TGTACTTCTG CGTCGTTGCG TTTTATTAGA 60

AGACTGATTT TGCTTTGAAC TACTTGAAGC TGTCGTTGTA TCCTGCGAAG TTTTTGCTAA 120

CTTCAGTTTC ATTTGCAGCG ACATGACTAG TTGCCAAGCC TAGTAAACAG ATACTTGCTA 180

ATCCAATTTT TGTTTTCAAT CTTTCCTCTC CTATAAAAAA TGTAACAGAC ATCTGAATGC 240 TGTTCCACCT AGCTTTTGCT ACTTACTGAT TATTTTACAA AGTCAAGCAA AGCCAAGAAG 300

CTTTCAGCTT CAAGTGACGC ACCACCTACA AGGGCACCGT CAACGTCTGG GCAAGCCATG 360

TATGAAGCAA CATTTTCAGG TTTAACAGAA CCACCGTATT GAACACGAAC TTTGTCTGCG 420

ACTTCTTGAC CAAAGTCAGC AGCTACAACG TCACGAACAA CTTTACACAT TTTTTGTGCA 480

TCGTCTTGTG AAGCTGATTT ACCAGTACCG ATAGCCCAGA TTGGCTCATA AGCGATAACT 540

GAGGCAGCAA CTTGTTCAGC AGTCAATCCA GCCAATGCAG CAGATACTTG AGCACCTACG 600

AATTCAGCAG CTTTACCAGC TTCGTAAGTT TCAAGTGATT CACCACAACA GATGATTGGA 660

AGCATACCGT TCGCAAAGAT TGCTTTTGCT TTTTTGTTGA TATCTTCGTC AGTTTCATGG 720

AAGTAGTCAC GGCGTTTCTG AGTGACCGAT AACAACGTAG TCAGTACCGA TTTCTTTCAA 780

AACTTGTGGG CTAGTTTCAC CAGTGAAAGC ACCTGCATTT TCTCCGTAGC AGTTTTGAGC 840

AGCGACTTTT AAGTTTGAGC CTTNGGCAAC AGCAAGNACA GTTGTCAAAT CAAGAGCTGG 900

AGCAGNGATA CCTGCTTCAA CAAGATCTGA TGAAGGAAGT TTTGATGCAA CTGCTTCAAC 960

GAATGNTCCA GCTTNTTGGG GATTTTTGTT CATTTTCCAG TTACCAGCGA TAAATGGTTT 1020

ACGTGACATT TCACATA 1037

(2) INFORMATION FOR SEQ ID NO:36:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1340 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:

CTTATCGTAC TAAGGATGGC AGTGTTCAAC TGTTCCGTCC TGATGAAAAT GCTAAACGCC 60

TGCAACGTAC ATGTGACCGT CTCTTGATGC CAACAAGTTC CGAACAGACA TGTTTGTAGA 120

AGCTTG AAA GCAGTTGTCC GTGCGAATGA AGAATACGTA CCACCATACG GAATAGGTGG 180

AACTTTATAT CTTCGCCCTC TTTTGATTGG TGTCGGAGAT ATTATCGGGG TAAAACCGGC 240

AGAAGAGTAC ATTTTCACCA TCTTTGCTAT GCCAGTTGGA AATTACTTTA AAGGTGGTTT 300

GGTCCCAACC AACTTCTTGA TTCAGGATGA GTACGACCGT GCAGCACCAA ATGGTACAGG 360

TGCGGCTAAG GTTGGTGGAA ACTATGCTGC AAGTCTCTTA CCAGGAAAAA TGGCCAAGTC 420

ACGCCATTTC TCAGATGTTA TCTATCTGGA CCCATCAACT CATACAAAGA TTGAAGAAGT 480

CGGATCAGCT AATTTCTTTG GAATTACAGC TGATAATGAA TTTGTAACAC CATTGAGTCC 5 0

ATCTATCTTG CCATCTATTA CCAAGTATTC CTTGCTTTAT TTGGCAGAAC ATCGCTTGGG 600

ATTAACTCCT ATTGAGGGTG ATGTTCCAAT TGATAATCTT GACCGTTTTG TAAAGGCAGG 660

TGCCTGTGGT ACAGCAGCGG TTATTTCTCC AATTGGAGGT ATTCAACATG GTGATGATTT 720

CCATGTTATT CTATAGTGAA ACAGAAGTAG GTCCTGTGAC ACGTAAATTA TATAATGAAT 780

TGACGGGTAT TCAGTTTGGC GATATTGAAG CGCCAGAAGG TTGGATTGTA AAAGTAGATT 840

AAAATAAACC AAAGGAGATT TTTTATGAAA TAGAAAAAGT GGCTCTTAAC AGCAGGAGTG 900

GTCCTGAGCA CGTCAGCTAT TTTAGTGGCT TGTGGAAAAA CTGATAAAGA AGCAGATGCA 960

CCGACAACAT TTTCTTATGT CTATGCAGTA GATCCAGCAT CATTGGGCTA CAGTATAGCG 1020 ACTCGAACAT CGAGGACAGA CGTTATTGGA AATGTTATTG ATGGTTTGAT GGAAAATGAT 1080

AAATACGGCA ATGTTGCTCC TTCTCAAAAA GACTATGATT TGAACAGTAC AGGATGGGCT 1140

CCAAGCTATC AAGATCCAGC GTCTTACTTG AATATTATGG ATCCAAAATC TGGTTCTGCC 1200

ATGAAACACC TTGGCATTAC GAAAGGAAAA GATAAGGATG TTTGTAACTA AACCTGGTTT 1260

GGATAAATAT AAGAAATTGT TAGAAGATGC TGTTTCTGAG ACCACTGACC TAGAGAAGAG 1320

ATATGAAAAA TATGCCAAAG 1340

(2) INFORMATION FOR SEQ ID NO:37:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 830 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:37:

CTCTGACGGC GTCGCCACTT AAGAAGAGTA TCAAAAAGAA AAATAGAAAA TTAACTAACA 60

AGGNAGAAAA ACACATGTCT AAAATTATCG GTATTGACTT AGGTACAACA AACTCAGCAG 120

TTGCAGTTCT TGAAGGAACT GAAAGCAAAA TCATCGCAAA CCCAGAAGGA AACCGCACAA 180

CTCCATCTGT AGTCTCATTC AAAAACGGAG AAATTATCGT TGGTGATGCT GCAAAACGTC 240

AAGCAGTCAC AAACCCAGAT ACAGTTATCT CTATCAAATC TAAGATGGGA ACTTCTGAAA 300

AAGTTTCTGC AAATGGAAAA GAATACACTC CACAAGAAAT CTCAGCTATG ATCCTTCAAT 360

ACTTGAAAGG CTACGCTGAA GACTACCTTG GTGAGAAAGT AACCAAAGCT GTTATCACAG 420

TTCCGGCTTA CTTCAACGAC GCTCAACGTC AAGCAACAAA AGACGCTGGT AAAATTGCTG 480

GTCTTGAAGT ANGACGTATT GTTAACGAAC CAACTGCAGC AGCTCTTGCT TATGGTTTGG 540

ACAAGACTGA CAAAGAAGAA AAAATCTTGG TATTTGACCT TGGTGGTGGT ACATTCGACG 600

TCTCTATCCT TGAATTGGGT GACGGTGTCT TCGACGTATT GTCAACTGCA GGGGACAACA 660

AACTTGGTGG TGACGACTTT GACCAAAAAA TCATTGACCA CTTGGTAGCA GAATTCAAGA 720

AAGAAAACGG TATTCGACTT GTCTACTGAC AAGATGGCAA TGCAACCTTT GAAAGATGCG 780

GCTGAAAAAG CCAAGAAAGA CCTTTCTGGT GTAACTTCAA CACAAATCAG 830

(2) INFORMATION FOR SEQ ID NO:38:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 667 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA ( i) SEQUENCE DESCRIPTION: SEQ ID NO:38:

GTGGTGGTTT GACTGCCCTT ATCGAAGCAG GTTTCGAANT CTAAGACANA AGCAGGTTAC 60

GCTCCAGAAT TGGCTTAACT TTGAAGTTCT TCACGGAAAT GAAATTGATC GTTGACTTGA 120

TCTACGAAGG TGGATTCAAG AAAATGCGTC AATCTATTTC AAACACTGCT GAATACGGTG 180

ACTATGTATC AGGTCCACGT GTAATCACTG AACAAGTTAA AGAAAATATG AAGGCTGTCT 240

TGGCAGACAT CCAAAATGGT AAATTTGCAA ATGACTTTGT AAATGACTAT AAAGCTGGAC 300

GTCCAAAATT GACTGCTTAC CGTGAACAAG CAGCTAACCT TGAAATTGAA AAAGTTGGTG 360

CAGAATTGCG TAAAGCAATG CCATTCGTTG GTAAAAACGA CGATGATGCA TTCAAAATCT 420

ATAACTAATT AGAAATATAT AGCGCTGGAG ATGATTTTAT GAAAAAGATT ATGAGAAAAA 480

TTGCATCGTT ATTATTGGTT CTAGTTGTAT AATGTAATTA CACCGTCGGT AATAGTGCTA 540

GCAGACCAAA ATAAAGCAGA TTGGTCGTAT GATGAAAATA CTGTAATTAA CATTTATGAT 600

GATGCTAATT TTGAAGATGG TAGGTTGCAT ATGACCTTTG AACAATTCTT CAAATTGGCA 660

CAAATAG 667

(2) INFORMATION FOR SEQ ID NO:39:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1397 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:39:

CGGTTCCAGA NACTGGTATG GCTAGGAGTC GCGACAAAGT GTATCTTATG ATGGTCGATT 60

TGATACTCAA TACGCTCAAT ACTTACGGAA AGAATAAACG ATCATTGTCA ACCGGAATAG 120

TATGATAATC GTTTCTTGGT GGAATAAGTT CAATCTTATC CTTCTTAGGC ACAATAATGG 180

AAGAGCCCAG TGTTCGATAA ACACGATTAT TAAGGCTGGC AATTTCCGTT AATTGCAAAG 240

CTTCAATGGT AGGGTGTAAA ACAGCACCAC CAAGAGACTA GTTATAGGCA GTACTACCAG 300

TCGGTGTCGA AACTGTTAGC CCGTCTCCAC GAAAACGTTC AAAGGGAACA CCATTTATTA 360

CAATATCTGC CACCATGGTT CGATCAGACC TGCGGATGCT GGCTTCGTTG AGTGCTCTGA 420

AAATCTTAAC TTCACCATTT TCAAGAAAGA CCTTCACATT CAGAACAGGG TAAGAAACCC 480

TTGCCCCAGT ATCTAGCTGC AAATTAGTCA CTAGCTTGTC CAACTCAAAA TCACGATAAT 540

CTGTATAGAA GCCCAAATGT CCAGTATGAA GACCGATAAA GCGGACCTTG TCAAGCTGAT 600

TTTCGTACTT ATGAAAGGCC GACAAGAGCA TACCATCCCC GCCAATGGAA ATGACAA T 660

CCGGATTGGT ATCATTGAGT TATAAACTGA TTTCTCTTCA AACGATCTCG CAATTCATAC 720

AAAACCCTTT GACTCTGCGG TTTTCTATTG GCTATCAGAT CAATTCGTTT ACCTGTATTC 780

TTCATCTGTA TCGTCACTGN NTCCAACACC GTCATTTAAT TTTCTACTCA AAGGATCAAA 840

AAGTGCCTGG GCTTCTTGGA TATCATCACG AATTTCACCC ATTTCTTCAT CCAACTGATG 900

GGCGATTCTA GCTGTAATTT CCAGTCGCTT CTTAATCTCA TCTGGGAAAT CCCCTTGGTA 960

CTTGTAGTTG AGAGAATGTT CTATCGTTGC CCAGAAATTC ATGGCCAAAG TACGAATTTG 1020 AATTTCTGCC AAAATAGTCT TAGCTCCATT GATGGTATCA ACCGTATATT CTACTACCAC 1080

ATGATAGGAA CGATAGCCTG ATGCTTTTCT ATGAGTAATG TAATCTCGCT CCTGTATGAT 1140

TCGCATATCC TGACGCTTGT GCAAAATATC CACTACTTCC TTGACGTCAT CTACAAACTG 1200

AACCATCACA CGTAAGCCAG CAATATCCTG CAAATCGTGT TCCAAGGTCG CATAAGTAAT 1260

GCCACGACGA GCCATTTTTT CTTTGATGCT CTCAATTGGC TTGACTCGAC CGGTCACAAA 1320

CTCAATTGGA GAATGCTTAT TTTGCTTACG ATATTGCTTA CGAATACCAC GAAGTTTAAT 1380

CTTTAACTCA CCAACAG 1397

(2) INFORMATION FOR SEQ ID NO:40:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 824 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:40:

CTCCCATGAC ACCTGCACGC TCCGTACGGG CCACGTGCTT TTTAATCCGT TCAACAACTT 60

CATAACCCGC TTCAACATCC ACACCCGACT GGGCATATGC ATTTTTATTT GTCATTTGTT 120

TTTTCCTTTT CTTTAATGGA GAATCTGTCG CCTACTTGTA AAAACTGGTC TTTTCTTCCA 180

AACTTCTACG ATAGTCTTCT TCGTAGTCAT AGAGAGGCGT TGGGTAGTCA CCGTCAAAGT 240

AAGCGACACA GAGACCACCG TTCGGCGCAT CTGTTTCGAT ACCAATCGAC TCAATCAAGC 300

TATCAATTGA AAGATAAGTC AGACTGTCCG CACCAATGAT TTGGCGAGTT TCTTCGACCG 360

TATGATTGGC TGCAATCAGC TCCTGACGGG TCTGGATATC AATCCCGTAG AAACATGGAT 420

ACGCTAGTGC AGGACTTCCA ATGGCAACGT GAACCTCAGT CGCACCCGCT TCTTTCAAGA 480

GCTGAACGAT ACGACGAGAG GTTGTTCCAC GTACAATGGA ATCATCCACC ATGACCACAC 540

GTTTGCCTTT GACAACACCC GAAACAGCAG ACAGTTTCAT CCGCACTCCT TGCTCCCGCA 600

ATTCTTGAGT CGGTTGGATA AAAGTTCGCT GGGTGTATTG GTTTTTGATC AGACCCATTT 660

CATTTGGTAA GCCTGATTCT TCCGCAAATC CCATAGCCGC GCTTAGGGAA GAATTGGGCA 720

CACCAACTAC AATATCTGCC TCATGCTTAA ATTCTCGCGC CAATTGCGCT CCCATTCTCT 780

TACGTGCCGT ATGGACATTG ACCCGTGGAT ATTAGAATCA GGGC 824

(2) INFORMATION FOR SEQ ID NO: 41:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1020 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1:

CTTCTTCCTT GGTACTTCCT CAATTGGATT ACCTTTGGCA TTGCTAGTTT TTCACTCCTA 60

CCTTATATCC AAGGCACTAA AATTATGTTT TACCGAGCAG TATTGGCTCG AAAACGTCCA 120

AAAGCTTGAA GGTTTTCCCC TCAAGCTTTT TTCTATCAAT GAATTTCTCC GCCTACCAAC 180

GTGAGTTCCT GATCTCCATG TTCTATCATA GCGCCGATTG CTGCTTCTAT CCCTCGCCGA 240

ATATCCACTA AACTCATAGT TGGAGTAGTC GGTCTGTTCA CCACCTGTTC CATCATATAA 300

GGAATATGCA TAAAACCTGC CTTAACATAT GGGAATTTCT TTTCTACCAA ATAGAGAGCC 360

TGATACATCA AATGACTGCA AACAAAAGTC CCTGCACGTA TTGGAAACAG ACTGCCGGTA 420

AGTCCTTCTT TTTTATTAGC TTGTACCATC GCTTTGATAG GTAAACTACT AAAATAGGCC 480

GATGCTCCAT CAATACGAAT CGGTGTATCA ATTGGTTGAT TGCCTTCGTT ATCAGGTATG 540

CGAGCATCAT CTTGATTAAT AGCCACTCGT TCAGGTGTTA AGCCGGTCCT GCCGCCTGCT 600

TGTCCAATAC AAAGTACAGC ATCTGGTTGA TATCGTAATA TTTCTGCCTC TAAAACTTCT 660

GACGACTTAT AAAAAACCGT TGGAATTTCT ACCCAGCGAA CTTCAGCCCC ATTAATCTCA 720

GATGGTAATA ATTTTACAGC CTCCAAAGCT GGATTAATCT TTTCACCTCC AAAAGGATTA 780

AAACCTGTAA CCAATATTTT CATTTTATTT TCCTTTACTA AAATGCGAGA AAGTACATTA 840

AGAATATGTG AATAACAATC ATTACTAGAG CAACACCTGC TTGAGCCTTT ATAACGCCAT 900

TCTGATCTTT CATATCCATC AATGCTGCTG GTAGAGCGTT AAAATTAGCA GCCATTGGGG 960

TCAATAAGGT CCCACAATAA CCTGCTGTCA TGGCAAGAGC ACCAGCCACA ATTGGATTAG 1020

(2) INFORMATION FOR SEQ ID NO:42:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 600 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:

CTCGTAAAAA CACTAAAGGA GGTAAATAAC CAATGTTAGT ACCTAAACGT GTTAAACACC 60

GTCGTGAATT CCGTGGAAAA ATGCGCGGTG AAGCAAAAGG TGGAAAAGAA GTAGCATTCG 120

GTGAATACGG TCTTCAAGCT ACAACTAGCC ACTGGATCAC TAACCGCCAA ATCGAAGCTG 180

CTCGTATCGC CATGACTCGT TACATGAAAC GTGGTGGTAA AGTTTGGATT AAAATCTTCC 240

CACACAAATC ATACACTGCT AAAGCTATCG GTGTGCGTAT GGGATCTGGT AAAGGGGCAC 300

CTGAAGGTTG GGTAGCACCA GTTAAACGTG GTAAAGTGAT GTTCGAAATC GCTGGTGTAT 360

CTGAAGAGAT TGCACGTGAA GCGCTTCGAC TTGCTAGCCA CAAATTGCCA GTTTAAATGT 420

AAATTCGTAA AACGTGAAGC AGAATAAGGA GAAGGCATGA AACTTAATGA AGTAAAAGAA 480

TTTGTTAAAG AACTTCGTGG TCTTTCTCAA GAAGAACTCG CGAAGCGCGA AAACGAATTG 540

AAAAAAGAAT TGTTTGAACT TCGTTTCCAA CCTGCTACTG GTCCAATTGG AAACAAACAG 600 (2) INFORMATION FOR SEQ ID NO:43:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1223 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:

CTTCAGCGAC ATATCTATCC ACAACTTCTC TCGATTCATG TTCCTCTGAA AATGCCTGAA 60

ATTTTAATTG ACTAATTTGA TCCTGATACG AACTATCTGC TAACAAAACT TCAAGATGGG 120

AAACATTTGC TAACGGATAA GGTCTTCTAT CCTTACCTAA CCAAGTTTCT GTCTCTTCAT 180

CCTCTATTAG TCCCCAGTTA CTGGCAAAGT CAGGATGATT CTCTAAAAAA ATACGTTCTG 240

TCTGAAAAGT GACTGACCGA ATGGGGAAAG AAGCTGTTCC TCTCTCAAAA CTAGTAAACA 300

ATGCACGCGC AATCCCCTGA CGGCGATGAC CTGGATGAAC CAGTATCGTC ACTTCTACAT 360

CTTGGTCATC TGCATAGACA GTTAATAAAC CAACAAGTTC GCCTTTTTCA TAATAAAGGA 420

AAAAGGCGGG CATGTTTGGA TCAAAATTAA GCATGTTAGA GAGATAGGGA TCGCGATAGG 480

TACCGTCATA GTTTTGGCAA CAGTTAATTA CTTTTTTCGC CTCAGATAGC TCTTCTTGGC 540

TTAACTTGTT TCTTGCTTGA ATCATATAGG TATCCTCTAC AAACCAGACG ATCTGTGACT 600

GGCATCTTTA GCCTGCTCGA GTTTATTGAC ATAATACTCC CGTTTTTCTT CGACTTCGTG 660

AATAACAGGC TCATCTTTCT TACCATGAAG ACGGACAATC TTGGCCGGAA TACCGACAAC 720

CGTCACATCA CTAGGTACAT CTGCTACGAC AACTGCTGCA GCACCGACCT TGGCATTTTC 780

ACCAATTTCC ACAGGCCCGA TAACTTGGGC ATGGGCTGAT ATGAGGGCTC CCTTTCGTAC 840

AGTCGGATGG CGTTTGCCAC AGTCTTTCCC TGTTCCCCCG AGAGTCACTC CGTGATAGAG 900

AAGAACGCCT TTTTCAACAA TCGCTGTCTC TCCAATCACC AGACCAGAAC CATGGTCAAT 960

AAAGACACCT GAATCAATCT GGGCTCCTGG ATGAATCTCA ATCTGAGTCC AAAAGCGCCA 1020

AAACTGACTG TGCATACGAG CTAAGAGTTT GAAGTCGTAC TTCCAGAGAA AATGCGAGAG 1080

ACGGTGGGCC GCCAAGGCCT TGACACCTGG ATAAGTCAGC AAAACCTCCA AAGTGGTGCG 1140

GGCCGCTGGA TCATTTTCTT TTACGATATC AATGGTTTCG CGCCACCACC CCATACATTT 1200

CTCCTTTTCT TACTCTGAAT CTT 1223

(2) INFORMATION FOR SEQ ID NO:44:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 845 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44:

GGTGAGTGCC TTTATTAGCG GAGCTTCTCA AGTGATTGTT GCCTTGATTA TCTTCCTTTC 60

ATGCTCTTTT ATCTCTTGCG TGATGGGAAA GGCTTGCGTA ACTATTTGAC CCAATTCATT 120

CCAAGCAAAT TGAAGGAACC TGTTGGACAA GTTCTATCAG ATGTGAATCA ACAGTTGTCC 180

AACTATGTTC GAGGGCAAGT GACAGTGGCT ATTATTGTAG CAGTAATGTT TATCATCTTC 240

TTCAAGATTA TTGGTCTACG CTATGCGGTT ACGCTGGGGG TTACTGCTGG TATTTTAAAT 300

CTGGTCCCTT ATCTTGGTAG CTTTCTAGCC ATGCTTCCTG CCCTAGTATT GGGTTTGATT 360

GCTGGTCCAG TCATGCTTTT GAAAGTAGTG ATTGTCTTTA TTGTAGAACA AACTATTGAA 420

GGCCGTTTTG TCTCTCCATT GATTTTGGGA AGTCAATTAA ACATCCACCC TATTAATGTT 480

CTCTTTGTTT TGTTAACTTC AGGATCTATG TTTGGTATCT GGGGAGTTTT ACTTGGTATT 540

CCGGTTTATG CCTCTGCTAA GGTTGTCATT TCAGCCATTT TCGAATGGTA TAAGGTAGTC 600

AGTGGTCTAT ATGAATTAGA GGGTGAGGAA GTCAAGAGTG AACAATAGTC AACAGATGTT 660

ACAGGCTTTG GAGGAGCAAG ATTTAACTAA GGCTGAGCAT TATTTCGCCA AAGCTTTAGA 720

AAATGATTCA AGTGATCTTC TGTATGAGTT GGCAACTTAT CTTGAAGGGA TTGGTTTCTA 780

TCCTCAGGCC AAGGAAATTT ACCTGAAAAT TGTAGAAGAT TTTCCAGAGG TTCATCTTAA 840

TCTAG 845

(2) INFORMATION FOR SEQ ID NO:45:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 802 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 45:

CTATGGATTA ATCTTCTTCT ATCTTATCCT GTTCCTAAAT ATGTTGGTAG AAAAATGAAG 60

CAGTTGTTAC GAGTGTCTGT ATTGGAAAAA AATTTTGTCT ATACAATTCT TTAAATGATA 120

TGAAGACTAG GAATGCCAAA ACACTGACAT ATTTCGTTTA AAGCCTATCC AGTCTCTTCA 180

ATTGTATTTG TAGAAATGCT ATCAGTAATA TATTCGCGAA CACTATGATT TACAACAGTG 240

TGGTCGTACA TCTTTGTAAC TTTATTATAC AACAACCATT TACAGGTGTA AAGTTGAGCA 300

GTGTCTTTAG TAAATTTAGG GACTTGTTTT GTCATAGTTT TGATACCTGT ATTCGTTGTT 360

TCATGAGTAT TTGACGTTTC TTTTCATGTA GGCATTTCAA CAATTAGAAT GATATTTTTC 420

CGAGGATGAA CTTATATATT ATGACTTTTT AGAGTTATGA TGCCTCTTGA TTTGACTATC 480

GCTATCAATT TCATCCACTT TTACAGTTTC ATGCAACATA GCGAGAAGGC GGTTTCCTAT 540

ATGGAAGTCG TCTTGTTTTC ATATTGTCTA AATACGAGAT ATTTACTACA GGTTGTAGAT 600

ATTGCAAGCT CAAATGATAT TATTTTAGAG GAGGAGACAA GTGAAATAAT GCCTGGTGAG 660

TTAGATGAAA TAAAAAGTAA GGAGTTGAAA GTACTGGTTC NTTGTGCAGG GTCTGGAACA 720

AGTGCGCAAT TAGCCAATGC AATTAACGAG GGCGCTCNAT TAGCAGAAGT TAGAGTGATT 780

GCGAATTCAG GAGCGCACGG AG 802 (2) INFORMATION FOR SEQ ID NO:46:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 928 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:

CTGGGACTCT CTTCGTAGAA GTCATGCAAG AATATTTTGA TCAAAAGAGG AAATCATGAA 60

AAAAAGAGCA ATAGTGGCAG TCATTGTACT GCTTTTAATT GGGCTGGATC AGTTGGTCAA 120

ATCCTATATC GTCCAGCAGA TTCCACTGGG TGAAGTGCGC TCCTGGATTC CCAATTTCGT 180

TAGCTTGACC TACCTGCAAA ATCGAGGTGC AGCCTTTTCT ATCTTACAAG ATCAGCAGCT 240

GTTATTCGCT GTCATTACTC TGGTTGTCGT GATAGGTGCC ATTTGGTATT TACATAAACA 300

CATGGAGGAC TCATTCTGGA TGGTCTTGGG TTTGACTCTA ATAATCGCGG GTGGTCTTGG 360

AAACTTT TT GACAGGGTCA GTCAGGGCTT TGTTGTGGAT ATGTTCCATC TTGACTTTAT 420

CAACTTTGCA ATTTTCAATG TGGCAGATAA CTATCTGACG GTTGGAGTGA TTATTTTATT 480

GATTGCAATG CTAAAAGAGG AAATAAATGG AAATTAAAAT TGAAACTGGT GGTCTGCGTT 540

TGGATAAGGC TTTGTCAGAT TTGTCAGAAT TATCACGTAG TCTCGCGAAT GAACAAATTA 600

AATCAGGCCA GGTCTTGGTC AATGGTCAAG TCAAGAAAGC TAAATACACA GTCCAAGAGG 660

GTGATGTCGT CACTTACCAT GTGCCANAAC CAGAGGTATT AGAGTATGTG GCTGAGGATC 720

TTCCGCTAGA AATAGTCTAC CAAGATGAAG ATGTGGCTGT CCTTAACAAA CCTCAGGGAA 780

TGGTTGTGCA CCCGAGTGCT GGTCATACCA GTGGAACCCT AAGTAAATGC CCCCCATGTA 840

TCATATTAAG GACTTGTCGG GTATCAATGG GGTTCTGCCT CCANGGATTG TTCACCCGTA 900

TTGATAAGGA TACGTCACGT CTTCTCAT 928

(2) INFORMATION FOR SEQ ID NO:47:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 663 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:47:

CTCTTTTACA GAGGTGTTTC CTATTTTGTG CTTCCATTTT TGGGGCAAGG AATTGTAGAT 60 GGGGATGGCA ATCCTATCTT TTTATTGATT ATGATATTCG TTTGCTTCAT AGTTTTAGTC 120 TTTTTGAAAT GGTTAGACTA TGATTTCACT AGATTGAGAA GGGAGTTTCT AGATACAGGT 180

TTTCAAAAGT CTCTTACTAA GATTAACTGG GCAATGGGGG CTTATTATCT AGTGATGCAA 2 0

AGTCTATCTT ACCTTGAATA TGAACAAGGT ATTCAATCAA CGACTGTTCG CCATCTCATC 300

CTAGTGTTTT ACCTACTCTT TTTTATGGGG GGTATCAAGA AATTGGATAC CTATTTGAAG 360

GAAAAACTTC AGGAGGAACT GAACCAAGAG CAGACCTTGC GCTACAGAGA TATGGAACGC 420

TATAGTCGGC ATATAGAGGA ACTTTACAAG GAAATTCGGA GTTTTCGCCA TGACTACACT 480

AACCTCTTAA CCACTTACGT TTGGGCATTG AAGAGAAGGA TATGGAGCAG ATAAAAGAGA 5 0

TGTACGACTC GGTCTTAAGG GATTCCAGTC AGAAATTGCA GGACAATAAA TATGACCTGG 600

GCAGATTGGT GAATATTNGT GACCGTGCCC TCAAGAGTCT CCTAGCTGGA AAATTTATAA 660

AAG 663

(2) INFORMATION FOR SEQ ID NO:48:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 653 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8:

CTAGATTAAT CTGATATTTC TTTTTGGCAA ACCAAATGCT TCCTATCAGA AAAGCTAGCA 60

ACAGCAACAT GGTAATAATG ATATGAATGG TCATTTTCTT CTCCTATTCT GCCTTTTCAA 120

TATCTTTTTT CATCTCGTCA ACATTGAACT TAGCAAACAA GTATTGACGG TCTTGGACTG 180

GGAAACGTTG GTCCAACTGG TCAACTGCTC CCACCTCGAT AATGCCTTCC TTGATGACAA 240

AATCCATGAC ATGTCCACCG AAGGTCAAAT CATCTGA AT GAAGTGCAGA TGGTAGCCTG 300

CCACACTGAC CCCATGGAAA ATCTCAGGCG TCCAGAAACC AACAATAGTC CCCGCAACAT 360

TGTCACGACT ATATTCCGGT TGATGGGTTG CGACATCAGC AAACTTGGTA TCGGGTGTTG 420

ACTTAGGAAT CATACGCACA TGCATATGTT AAAAATTCCC CCCCGAATCT TGATAGAGCG 480

GAAAAGATTT TCCCCATCAT AATAAGACTC AATTCGTTCT TTCAATTCCT TGTCTGTCAT 540

CTCAAAGCGC TGGCGAAAAA TGACCTCTGC CTGATGCGGT ACCACTGCAG CGTAAGGAAT 600

AAGGGCATCT GGTGACACTT CCACAATTTC TGGCTGGTCT CCTGACCCTT TGG 653

(2) INFORMATION FOR SEQ ID NO:49:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 989 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 49:

CTACGATATC TTTGGTCTTT TGTAAGATAT GAGGTCCACC CTTATGCGCC TCAGTTGGCA 60

TTTCATGCGA TTCAAGAAGT TGCCCCTCTT GATCAACCAA ACCATACTTG ATGTTGGTTC 120

CACCGATATC AATTGCAACG TAATATGTCA TAAATACCTC CTTTTAGATT AGAGGAAGCG 180

CTCCTTGGTT TCACGAATCA AGGCAGCAGC CGCTTCTACA ACTGGACGAT CTTCTTCAGT 240

CACTGGTGTC AATGGTGAAC GAACAGATCC AATATTCAAG CCTTCATTGA TTTTCAAGAC 300

TTCTTTGATG ACACCGTACA TATTTCCATG AGCAGAAGTG AGTTTACCAA TGATTGCGTT 360

GATAGCATAC TGCAATTCAC GCGCTGTTTC TAGGTCCTTA TCCGCAATCA ACTGATTGAG 420

TTTCAAGAAG AGTTCTGGCA TAGCACCATA AGTACCACCG ATACCAGCCC TAGCCCCCAT 480

GAGGCGTCCT CCTAGGAACT GCTCATCAGG ACCATTAAAG ACGATATGGT CTTCTCCACC 540

AAGGCTGACA AAGGTTTGGA TATCTTGAAC TGGCATAGAA GAGTTCTTCA CACCGATAAC 600

ACGAGGATTT TTCAACATTT CTGTGTAAAG GCTTGGAGTC AAAGCAACCC CTGCCAATTG 660

AGGAATGTTG TAAATCACGT AGTCTGTGTT TGGAGCTGCA GAACTGATAT CGTTCCAGTA 720

TTTGGCAACT GAGTTATTCT GGCAAGCGGA AATAAATTGG TGGAATCCGT TGCAATAGCA 780

TCTACTCCCA AGCTTTCAGC ATGGCGAGCA AGTTCCATAC TATCTTTAGT ATTATTGCAA 840

GCAACATGGG CAATAATGGT CAATTTACCT TTGGCTACCG CCATGACTTC TTCCAAAATC 900

AACTTGCGAT CTTCAACGCT TTGGTAGATA CATTCACCAG AAGAACCATT GACATAAGAC 960 CTTGAACACC TTTATCAATG AAGTATTGA 989

(2) INFORMATION FOR SEQ ID NO: 50:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1671 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50:

TCAAAGAGTA ACAAAGGCAC CAAATTCTCG ATAGGAACGA TTTAGCACGG TAAACTTCAT 60

CCACTTGGGT TCACGGAACC AAACCAGCAA TAATTTCTTT GGGCACGGGT TAATAGCATT 120

TTGGTCAACT AGGAGTAGAT AGAACACATT TCNTTCTTCG TCTATATCAA TCT ACACC 180

TGTTTCAGCG ATAATCTTGT CGATGGTTTC TCCACCCTTA CCGATGACAA TCTTAATCTT 240

GTCCACATCA ATCTTGATCG TATCAATTTT CGGAGCAGTT GGAGCCAATT CTGGACGAAC 300

TTCTGGAATG GTTGCTTCAA TGACATCAAG GATTTCAAAA CGCGCTTTCT TGGCTTGAGC 360

AAGAGCCTCC GTCAAGATTT CTGCAGTAAT CCCTTGAATC TTGATATCC TTTGAAGGGC 420

TGTAATCCCA TCACGAGTAC CTGCAACCTT GAAGTCCATA TCTCCAAAGT GATCTTCCAA 480

ACCTTGGATA TCTGTCAATA CTGTGTAGTT ATTTCCATCT GAGATAAGTC CCATAGCAAT 540

ACCAGCTACT GGCGCCTTGA TTGGCACACC ACCAGCCATA AGGGCAAGAG TTCCCGCACA 600

GATAGAAGCT TGAGATGAAG AACCGTTTGA TTCCAAAACT TCTGCTACTA GACGGATAGC 660 GTATGGGAAT TCTTCCAAGC TTGGCAAGAC TTGAGCAAGA GCACGCTCAC CAAGGGCACC 720

GTGACCGATT TCACGACGAC CTGGCGCACC GTAACGACCT GTTTCCCCTA CAGAATATTG 780

AGGGAAGTTA TAGTGGTGCA TAAAGCGTTT CTTGTACTCT GGATCCAAAC CATCAATGAT 840

TTGAGTTTCT CCCATCGGAG CCAAGGTCAA GACTGAAAGA GCTTGAGTTT GCCCACGAGT 900

AAAGAGACCT GAACCATGTT ACACGAGGAA GGAAGTCAAC AACCGCATCC AAAGGACGGA 960

TTTCATCGAC CTTACGACCA TCAGGACGCA CCTTGTCTTC TGTAATTAAA CGTCGCACTT 1020

CTGCGTGTTC CATTTGTTCC AAGATTTCAG CCACATCACG CATAATACGG TCAAATTCTT 1080

CGTGGTCCGC ATATTTTTCT TCGTAAACGG CAGTCACTTG GTCTTTCACT GCTTGAGTTG 1140

CAGTTCACGG GAATCCAATT TCTCTTCTAC TTGAACTGCC TTTTGGAGGT CACTGTTGTA 1200

GGCTGCAATG ATTTCAGCTT GCAATTCAGC ATCCACGTGA AGCAATTCCA CTTCTGCTTT 1260

TTCTTTACCG ACAGCAGCAA CGATTTCTTC TTGGAAGGCA ATCAATTCTT TGACAGCTTC 1320

GTGCCCTTTA AGAAGCGCTT CCAACATGAT TTCTTCTGAC AATTCTTTGG CACCAGACTC 1380

TACCATGTTG ATAGCGTGCT TGGTTCCAGC TACTGTCAAT TCAAGAAGAG ATTGCTCTGC 1440

TTGTTCTTGA CTTGGGTTGA TGATGATTTG GCCATCTACA TATCCCACTT GTACCCCAGC 1500

AATTGGTCCG TCAAATGGAA TATCTGAAAT AGACAGTGCC AAAGATGAAC CAAACATAGC 1560

AGCCATTGGT GCAGATGCAT TTTCATCATA AGAAAGCACT GTATTGATGA CTTGGACTTC 1620

ATTACGGAAA CCTTCCGCAA ACATAGGACG AATCGGACGG TCAATCAAAC G 1671

(2) INFORMATION FOR SEQ ID NO:51:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 731 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51:

CTCAGTATCT TTGTAATCAA CATATCCAAT TTTGTTTGCT GCGATGTANT CAACTTTTTT 60

ACGGCGTTTG AATCCGCCAC GACGTNGTTG AGCCATGTTT TTNCTCCTTT ATAAGTTTAG 120

TTGTCCATTA GAATGGTAAA TCATCANCTG AAATATCCAA TGGGTTTGTT GCTCCAAATG 180

GATTTTCATT ACGTGAAAAG TCTGGTACTG AATTTGTAGG TGCTGAATAG TTTGCAGTTG 240

GTGCAGAGTA AGCTCCACCT GTGTGACCCT CACGCACACT ACGGCTTTCC AACATTTGGA 300

AATTCTCAGC CACGACCTCT GTCACGTAGA CACGTTGTCC TTGCTGGTTA TCGTAACTAC 360

GAGTCTGGAT ACGACCTGTC ACCCCGATAA GTGAGCCTTT TTTAGCCCAG TTAGCAAGAT 420

TTTCAGCCTG TTGGCGCCAC ATAACGACAT TAATAAAATC AGCCTCACGT TCACCATTTT 480

GACTCTTAAA TGTACGGTTT ACTGCAAGAG TAAAAGTCGC AACTGCTACA TTTGATGGGG 540

TATAACGCAA CTCAGCGTCA CGTGTCATAC GCCCTACAAG TACAACATTG TTAATCATAG 600

TTTACCTTCT TACGCGTCAA TTTTGACGAT CATGTGACGA AGAATGTCAG CGTTGATTTT 660

GGAAAGACGG TCAAACTCTT TAGAGAGCTG CATCGNTCAT TTGCTTCAAC GTTAACGATG 720

TGGTAAAGTC C 731 (2) INFORMATION FOR SEQ ID NO:52:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 992 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52:

CTGGGTTTTA CCACGTTTTC CTGATGTACG AGCGAGATCC TTACGGTTCA ACATAGTGTT 60

GATAAAGCTG GATTTACCAA CATTTGAACG CCCTGCTAGG GCAATCTCTG GCAGTTCATC 120

CTGCGGATAG TGGGACTTAT TAGCTGCACT GAGCAAGATT TCAGCATTGT GTGTATTAAG 180

TTCCATAGTC ACCTCTAGGC TGTTTCTAGG ATCGGTTTAT CCGTTCCATC GACAGTTTCT 240

TTAGTGATGC GAACCAATTT CACATTTTCC TGACTCGGCA CCTCAAACAT AACATCTAGC 300

ATGGTTTCTT CGATGATGGA GCGAAGTCCA CGCGCCCCTG TCTTCCGTTC GATTGCTTTA 360

TTAGCAATCT CTTGAAGGGC TTCGTCGTCA AATTCCAACT CAACATCATC A AAGAAAGC 420

AAGGTTTGGT ATTGTTTCAC CAAGGCATTT CTTGGCTCTT TCAAGATGCG AACCAAGTCC 480

ATCAACGGAC AATTGCTCAA GAGCCGCAAA AACAGGCAAG CGTCCAATCA ACTCAGGGAT 540

AATACCAAAT TTTTGAATGT CTTCAGCGAT GAATTCTTGC ATGTATGAGC TGTTTCTCTG 600

TCAATCGCCT TATTGTTTTG ACCAAATCCG ATGACTTTTT CACCCAGACG TTGTTTGACA 660

ATTTCTTCAA TACCATCAAA AGCACCACCC ACGATGAAGA GGATATTTTT TGTATCCACT 720

TGAATCATCT ACTTGTTGTG GATGTTTGCG TCCACCTTGA GGCGGCACGC TAGCAACAGT 780

TCCCTCAATA ATCTTGAGAA GGGCTTGTTG CACCCCTTCA CCAGAAACAT CACGTGTGAT 840

AGACACATTC TCACTCTTCT TGGCAATCTT GTCAATTTCA TCCACATAGA TAATGCCACG 900

CTCTGCACGT TCGATGTTAA AGTCAGCAAC CTGCAAGAGT TTGAGGAGTA TATTTTCCAC 960

ATCCTCACCC ACATAACCAG CCTCCGTCAG AG 992

(2) INFORMATION FOR SEQ ID NO: 53:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1299 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53:

ATTTTCACAG GGCAGGATGC GGAACGACTA GCCCCATACT TTAACGGAAT TTTGGTAGGG 60 ACAGCTCTTA TGCAGGCAGA AAATGTGGCC CAGAGAATCA AGGAGTTGCA GATTGACAAA 120 GGTTAAAATT TGTGGACTAT CGACCAAAGA AGCGGTGGAA ACAGCCGTTT CAGCAGGAGC 180

CGACTATATC GGTTTTGTCT TTGCACCTAG TAAAAGACAG GTGACTTTAG AAGAGGCAGC 240

TGAGTTGGCA AAGCTTATTC CTGCAGATGT GAAAAAGGTT GGAGTATTTG TTTCACCAAG 300

TCGGGTAGAA CTGCTGGAAG CGATTGACAA AGTTGGCTTG GACTTGGTTC AAGTTCACGG 360

TCAGGTGGCA GATGATTTAT TTGAGAATTT GCCTTGTGCC AGTATTCAGG CTGTGCAGGT 420

AGATGGAAAT GGGCATGTCC CCAATTCTCA GGCAGATTAT CTACTCTTTG ATGCCCCTGT 480

GGCAGGAAGT GGCCAGTCCT TTGATTGGGG TCAACTGGAT ACGACTGGAC TAGCACAGCC 540

CTTCTTTATC GCAGGTGGCC TTAATGAAGA TAATGTAGTA AAAGCAATTC AACATTTTAC 600

TCCCTATGCA GTAGATGTAT CGAGCGGAGT GGAGACAGAT GGACAAAAAG ATCATGAAAA 660

GATTAGAAGA TTTATAGAGA GGGTAAAGCA TGGCATATCA GGAACCAAAT AAAGATGGAT 720

TTTACGGAAA ATTCGGCGGA CGTTTTGTCC CAGAAACATT GATGACAGCA GTTTTGGAGT 780

TGGAGAAGGC CTACCGTGAA AGTCAGGCAG ACCCAAGTTT CCAAGAGGAA TTAAACCAAC 840

TCTTGCGCCA GTACGTAGGA CGTGAAACTC CTCTT ACTA CGCAAAAAAC TTGACCCAGC 900

ATATCGGCGG AGCCAAGATT TATCTCAAAC GGGAAGACCT TAACCATACA GGAGCCCACA 960

AGATTAACAA TGCCTTAGGA CAAGTTTGGC TTGCCAAACG CATGGGTAAA AAGAAAATTA 1020

TCGCAGAAAC GGGTGCTGGT CAGCACGGTG TGGCAACTGC AACTGCTGCG GCCCTCTTTA 1080

ACATGGAATG TACCATCTAC ATGGGTGAGG AAGATGTCAA ACGCCAAGCC CTCAATGTGT 1140

TCCGTATGGA GCTTTTGGGA GCTAAGGTTG AAGCAGTGAC AGATGGTTCG CGCCTGCTCA 1200

AGGATGCGGT CAATGCAGCC CTTCGTTCAT GGGTGGCTAA TATCGACGAT ACCCACTATA 1260

TCCTTGGTTC TGCCTTGGGG CCTCATCCAT TTCCAGAAA 1299

(2) INFORMATION FOR SEQ ID NO: 54:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1078 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:54:

CTGTTGAATC AACAACACGT ATCCAAGTAT CAGNATCAAA TTATGCAGGT AATCGTACAA 60

TTGGAAATCA CCGTGGATGG TTCAATCCAA CAACAACTTC TGAAGGTTTT GTTACATATA 120

TTTATGCAGA TTAATTTACA GAGGGACTCG AATAGAGCCC TCTTTTCAGG TTTTACCGTG 180

ACAATCCCTA TTAAAAATTA TATCAAAATA GCTTGAAAAT ATTGGAAAAG TATGGTAGAA 240

TGAAAATTGT CGTGTGAACG ATAATACTCA TTCTTGATGA ATTGTGAAGC AGTTGCCCTT 300

GGGTCGTTTT GCGAGTTGAA GTCAAGAAGA GGAAAAAAAC AAAAAGGAGA AATACTCATG 360

GCAGTAATTT CAATGAAACA ACTTCTTGAG GCTGGTGTAC ACTTTGGTCA CCAAACTCGT 420

CGCTGGAATC CTAAGATGGC TAAGTACATC TTTACTGAAC GTAACGGAAT CCACGTTATC 480

GACTTGCAAC AAACTGTAAA ATACGCTGAC CAAGCATACN ACTTCATGCG TGATGCAGCA 540

GCTAACGATG CAGTTGTATT GTTCGTTGGT ACTAAGAAAA CAAGCAGCTG ATGCAGTTGC 600

TGAAGAAGCA GTACGTTCAG GTCAATACTT CATCAACCAC CGTTGGTTGG GTGGAACTCT 660 TACAAACTGG GGAACAATCC AAAAACGTAT CGCTCGTTTG AAAGAAATTA AACGTGGATG 720

GAAGAAGATG GAACTTTCGA AGTTCTTCCT AAGAAAGAAG TTGCACTTCT TAACAAACAA 780

CGTGCGCGTC TTGAAAAATT CTTGGGCGGT ATCCGAAGAT ATGCCTCGTA CCCCAGATGT 840

GATGTACGTA GTTGACCCAC ATAAAGAGCA AATCGCATGT TAAAGAAGCT AAAAAATTGG 900

GAATCCCAGT TGTAGCGATG GTTGACACCA ATACTGATCC AGATGATATC GATGTAATCA 960

TCCCAGCTAA CGATGACGCT ATCCGTGCTG TTAAATTGAT CACAGCTAAA TTGGCTGACG 1020

CTATTATCGA AGGACGTCAA GGTGAGGATG CAGTAGCCGT TTGAAGCAGA ATTTGCAG 1078

(2) INFORMATION FOR SEQ ID NO: 55:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 800 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:55:

CTATGAGGGA TATAAAGTGA GAGAGTTGGG CCAACGTTCC AAAAACGTCC TAAATTCTGC 60

CCATTGACAA AGGCAACCCC CTTACCAAAC TCAGACNAGT CTAGGTAAGT ATCTTTTGGC 120

TATTCGACTG TAAAGTCATA AGCGTAAAAG GCTGGTTGTC CTTGAGTCCA TCCTTTGGAA 180

AAATCAATTT TCTCAGGATT GTCTAGTGGG AGTGGATAGT GTTTCCAGTT TAGTAAGAAA 240

TGCAGATCCT TACAGACCCC TGTCCGAATT CCCTTACGTT GCGTATCCGC TAAGAACTTA 300

TGCCCATAGT TGACACGCCC CATATTTTCT ATCAAGATAT CTAACCTAGA TAGCCCTTTC 360

TTTTTACCTT GATAAAAAAT ATCTTCCCCA ATCTCTGTCT GATATTGAGT TTTAACCCAC 420

TGACCATCGA CATACAGCTG GGCCCTATCT CGACCATCAA TGATACGAAG TCTTTCTTCT 480

TCTGCATCCC AGTTTGTTTC TGTTCGATAA AGTAGG AGC CATAACTTTG TCCCAGCTCC 540

TCCATCTTTT GAGGATAGAG ACTTTCTACA GGGACTTGAC AAGCTATCTA AGGTTTCAAA 600

CAAAGAAACT TTTTCAACTA GTGGAATAGC ATCCAACTCC A ACTCTCTT TGTAGAGTGG 660

TTCCAACTGC GGATACTCTG AAAAATGTGT TGCCATCATC TTCTTGACTG CAAGATATTT 720

AGCAGTTGGA TTTCCTTCTT CATCCAGAAG GGCATCGTAA TCATAAGACG TTAACTTGTG 780

GCAGGTCCAA ATTCCTCGAG 800

(2) INFORMATION FOR SEQ ID NO:56:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 769 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56:

CTCACGCAGT TCTGTTACCA AAGACCGTTC AAAAAGCAAA CTAGCAATAC TTATAACTTA 60

TTAGAAATTC CTAATTTTAC CTTGCTAAAC GAATACAGGT CACGATGCCA TCTGAGTCTG 120

TGATTTCCAA TTGGCTCGAT GTCATCCATT TGATTGGTAC GTCAACTTCT TGTGCTCGTT 180

GGGCAATCGT TAACAGTTCT TCTTTATGTG CAACTTCGAT GACATAGTAG GCTAAACCTG 240

GTAAGCCTTG CTTACGCGGA AGCCAGACCT TTTCCTTCCC CATTCGTTAA CTGCTAAATG 300

ATGATGGTAA TCTCCAGCCG CAATCCAACT AGCGCCAGGC ACACTGAATT TATTCTCTAG 360

CCCTAACACC TTTTGATAAA ACTGGCTGGA CTTTCGACTA TCCTTGACGG AAAGATGAAT 420

ATGCCCCATT CTTGTACCTT CTGCCAGGAT AAAGGGCTCT ACTCTTTCCC CCAACTCATA 480

AATGTCCTGC GCCGCAAGAG CCTCCGTCAC TCCGATAATG CGTCCATCTT CTCGAATATC 540

CCATGTGGAA ACTGGCTTAT CTCGATAGAG TTCAATGCCA TTTCCCTCCA AATCTTCCAA 600

GTAAATAGCT TCACTGTAAC CATGGTCTGC ACCGCCGACA AGAGGAATTT GCAAATCTGT 660

CAGATGTTTC AAGACATCAG CCAAAGCCTT GCGTGTGGGC AAGAGAATGG CCAAATGGTA 720

AAGACCATAA TGTTCCCTCA CTTCTCCGCT CTTCTTGTGC TTGAATCAG 769

(2) INFORMATION FOR SEQ ID NO: 57:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 637 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:57:

TTACCCCAAG CCTGCAACTT CCCAAGCTGA TTGGTTGAAT GATTTGTCAT CAACACCACC 60

AGTATCAGTG ACGATTGCTG CTTTTGTCTT CACATCAGAA GATGAAGCTG CGTTACGAGA 120

AGAGCGGTTA CCACATGCAG CAAGTCCAAC TGCTGCCACT GCAACTAGGC CAAGACCTAG 180

CCATTGTTTC TTGTTCATTA CTGAACCTCC TAAATAAGAT GTGCAACGAT GTTGCAAGTA 240

TGGATTGATT GGTCACAAAG ACCCTTGCCA CTCAAAGAGC GACTCAGACT AATTTAAGTC 300

TGTAAAAGAA TATGGAAGTA ACTCCCCGAC CGTCATCTCG ACCGTCGATT TATCTTTTGC 360

GACTAAGGTC ACTTTTAAAT CTTGTTCAAA AAATTCGACC ATTACTTGGC GACAAGCACC 420

ACATGGTGAA ATCGGTTTTT CAGTTTGACC ATAGACAATC AATTCTGAAA ATTCTCTTTG 480

GCCTTCAGAT ATAGCCTTAA AAATAGCTGT TCTCTCACCG CAATTGGTCC AAAGGATAGC 540

TAGCATTTTC GATATTCACT CCCGTGTTAA ACATTTCCGT CTTTGGCTAC TAAAACTGCT 600

CCGATAGGAA AGTGAGAATA GGGGACATAG GCATGTT 637

(2) INFORMATION FOR SEQ ID NO: 58:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 940 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58:

CTGAGGATAA TGACATCTGC CANAGGAGCA AAACTAGCAA AATCATCNGT TGCACGGTCA 60

ATCATGCCTT CTTTCAAGGC GATATCTCTC GAAGCTTGAC TACGGATTAT AACCTAAAAT 120

TTCATAATCT GGATGATCGC GTTTGATACC AAGTGCCATA GAGGCTCCAA TCAACCCAAG 180

ACCTGCGATA TAGATTGTTT TTGCCATAGG AACTCCTTAA TAGTTCTTTG TATAGTCTCG 240

GTGTTTGGCT ACCGCTTCTT TTAGTTCCTC AAGATTATCT GATGAGAATT TTTCGAGGAT 300

TTCTTGCGCC AGAACCGTTG CTACAACTGC TTCCATGACC ATTCCTGCAG CTGGAAGAGC 360

AGTCGGATCA CTTCTCTCCA CGGTTGCCTT GTAAGGTTCG TGGGTTTCGA TATCCACACT 420

CATAAGAGGT TTATAAAGAG TAGGAATGGG TTTCATGACC CCACGAACAA CGATGGGTTG 480

CCCATTAGTC ATACCACCTT CAAAACCACC TAGATTATTG GTACGGCGAG TATAACCGTC 540

TTCTTTAGAC CAGAGAATTT CATCCATAAC TTGGCTGCCT TTACGATAAC CAGCCTCAAA 600

GCCAAGACCA AATTCCACCC CTTTAAAGGC ATTGATAGAG ACAACAGCTT GAGCCAATCT 660

TGCATCCAAT TTTCTATCCC ATTGGGACAT AGGAACCAAG ACCAACTGGG AACGCCTCCG 720

ACGACTGTCT CCACAACCCC ACCGATGGTA TCACCATCAC GTTTGATTTG GTCAATATAG 780

TCCTTGATTT CCTGTTCTCG TTCTTGGTTG ACAATAGAAA ACTTCCAGAC TGGGCAGCTC 840

TTTGCTTTAA TTTCCAGCGA CTGTCAGATT TTCCAGGAAC ATCCATTCCC TTGCCACCAA 900

AGACCACGAC ATGGTTGGCA ATCTCCATAT CCAGATTCGA 940

(2) INFORMATION FOR SEQ ID NO: 59:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 990 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:59:

GATTCTACAG GATCCATTTT ACTATCTTAC GCGCCGGGAA GTAGGCTGAG ACATAACCAA 60

GTAATAGAGC CAACAACTAG AGTTCCTAAA ACAGATAAAA GATTTAATTC AAAAACCTTA 120

GTGATGGATG GGTAAAAGTG ACTTACAATC GCATTCGCCA AACTTCCCAC CCCTTGTGCA 180

ACCAAAAATG CCAGCAGCAA GGCGATGCCT ACAATCCAGA TAGCCTCGTA AATAAAAATT 240

CCTTTGACAT CACGATTCTG ATAACCAACT GCTTTCATGA CACCTATTTC CTTGGAACGT 300

TGCATGATAT TGATGTAAAT AATGATACCA ATCATAACCG CTGCTACCAC AATAGCTTGT 360 GATGAAAGCA CAATCAATAA TCCCTGAATA ACACGAATAA AGGTAATCAC AATATCAAGA 420

ACTCTCTGTT AAGAAAGCAC AGTATACTTC TTATTTTTCT GTAATTCTTC TGTTACTACT 480

TTTGTCTGTG ATGGATCTTT GAGTTCCAAG ATAAAATAAG ATACAGCTTT CGTAAATCCA 540

GCCTCTTTCA AAATCGTTTC CATTTGATGA GACAGCATGA AACTGTTGCT GTCCTCCATG 600

TCATCTTCAT CATTGATTAC ACGTACAATC TTCGTTTGAA ATTGAGCAAT CTTACTAGTT 660

TCGGCAGCAC TTTCTACAAT GCTGACTGAG ACTGATTTGC CAATAAGATC ATTAGCTGTC 720

AAATTTTTTC CTGTCTGTTC ATTCCAATTT TTTAGTAAAG CTGCTTGGAA TCGTTAATCC 780

CTGTTCATTT GTATCAGTAT AGAGGGATCC AGCCAACACT TTGTCCGTCT CATTATTACT 840

AACAGAGATA CTTGTATCAT CATAAAGACT CACTACTTGA GCATAAGAAG CATCGTTTGA 900

CTCAAATCCA TTTCTTGCCC ATCTTTTCTT GCCCATCTAT AGTAATATTT GACATGTTCA 960

TCCCNAAAGG ACTCTCCAAA TATNNNATAG 990

(2) INFORMATION FOR SEQ ID NO:60:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1253 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:60:

ATCGGCTAAG ATGCGTGGAG CATCACAAAT TATCCTTATG AGCCGTCATG AAGACGTCAA 60

AAGATGGCTA TGGAGTCAGG TGCGACAGCT GTTGTTGCAG AACGTGGTCA AGAACGAATT 120

ACCAAGGTGC GTGAAATCCT CGGCGGAGGA GCAGACGCAG CACTTGAATG TGTTGGTACG 180

GAGGCTGCTA TAGAACAGGC GCTAGGTGTT CTTCATAATG GAGGGCGTAT GGGCTTTGTA 240

GGAGTCCCAC ACTATAATAA TCGTGCTCTT GGTTCGACAT TTATGCAAAA TATCTCTGTA 300

GCAGGTGGGG CAGCTTCTGC TACAACATAC GATAAGCAAT TTTTACTAAA AGCCGTCCTT 360

GATGGTGATA TCAATCCAGG TCGCGTCTTT ACTTCAAGTT ATAAACTGGA AGATATCGAC 420

CAAGCCTACA AAGATATGGA TGAACGTAAG ACCATTAAGT CTATGATTGT AATCGAATAA 480

AAAACGAATA GGAGTTTTAG AACTCTATTC GTTTTTTATG TTATCCTATT CTTGATTTAA 540

GGTACTTTCT CTTAATGTCA GTCTGGTTCC CAGCATGGTC AGGCTAGGGA TTTTCCGACC 600

GTGGAGGACT TCCTTGTTAA GAATATCCAT ACCTGCTCGG CCCATTTCTT CAGTATAAAC 660

TGTAATACTA AGAGAGGGGA GGATAGACCT GTTTGGTCAG ACTAAGTGTC GTTAAAAGGA 720

AAATGAGGCT GACGCGATCT GGCAGGCTGA TTCCAGCTTC TTGGAGGGCA CGGAGGGCAC 780

CGATAGCTAA ACTATCGCTG GCTGCGAAAA ATGCTGGCGG AAGTTGGTCT CCCAAGCTCT 840

GAATGGCCTC CTTCATTAAG TCATAGCCAG ACTGGGCAGT AAATCTTCCT TGAAAGACCA 900

GTTCATCATG ATAGATTCCC CTCGCTTGAC TGTAGTTTTT GAAGTTTTCT AGACGCTTGT 960

CCTGAATGAT TTCTTCTTGG TCTGTAGTTT CTTCAAGGCC TGTTAGAATC CCGATACGGT 1020

CCATTCCTTG ACTGAGGAAA TAATCGACAA CCTGTTTCAT AGCAGTGTAA AAATCCGTGA 1080

TAATACAGGT ATGTCCCAGG GAAAGTGTAT CGCTGTCTAG AAATACAAGA GGCTTTTGGT 1140

ATTCTTCAAA GGCAGAAATC TGAGCTTCTT GATAGGATTG ATTCTGCTAG GGATAACAGC 1200 CAAAGGCAAT CCTCCCTTTA TCCACCTCAT ATTTGAAACC ATTTCAGCTC TTA 1253

(2) INFORMATION FOR SEQ ID NO: 61:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1211 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61:

CGTGTACCAT CAAGAGGCTA ATTGATGTTT CTTCCCCCTG TGCCTCTCTT GTCAACATTT 60

CTGTTTGAGC CTTATGCGCC TGTAATAAGG CAGCATTCGC ATCAGCTAAT CTTCGATTGG 120

CTTTAGAGAA ATCCCCTTTT TTTGCTGCCT GAATAGCCTC CATAGCATTA CTTTTGGCTT 180

CCCCACCATA CATAATTAGC CCCATTACAG ATTCTAAATT ACTTTCATCC ATAACATTCT 240

CCTCAATCTT AGTCTAATAA ACTTTCAGCT AAATCTAAGA CTTTAGAACC ATTCATCATT 300

CCATAATCTG TCATCGGAAT AACCGCCACA GGAATCTGTC TATCTTTTAG TTTTTCTTGA 360

AAGTCCCCTA GTAAATAGCG AACTTGAGGA CCTAAAAGCA ACACATTTAC TTCTTTTGTT 420

GCTACAATTT CTTCTGCTTC AGGAGCTGGA ACTGCAAAAA TTTCTGCATC CAACCCCTTA 480

TCTTCTGCTG CCTTTTGCAT CTTTGTC CT AGCAGACTTG TACTCATACC TGCTGCACAT 540

GCTAACATAA TTGTTACTTT AGCCATAGCT TACTCCTTTA TCACCTATTT ACTGACCTAG 600

CCAAGCGAGA TACTGTATGT CTCACTCCTC TAATTGCCTT GCTCAATGCA TAAATATTAT 660

CGACTGTTGC CAGTCCCCCA TATCCTGCGT CACCTATATG TTGAATATCA ACTCCACAAA 720

TTTTATTTCT AAGTGCAATT TCCTTAATAG TATCTGTATC AGATGTTTCT TGGCTAGTAC 780

CAATAGCACT CAATACAAGA CCACCCTTAC TATGAACGAG ATCAACGACT TCACGCAACT 840

CTTGGTCATG AAAGGCTGGA ACGGTTCCAA CTGCTGGAAC AAGTATCACA TCCGCACCTG 900

CTTCCAACAA TTGCTCTGCG ACAGAAAGCT CTGCCACAGG CTCATTCACT CCTGCCCCGT 960

GCATCTTACC TGCAATAATC AAACCAGAAA AGTTTTCCTT AGCAGTTTGA ACAGCCTTAA 1020

TGATTTCTCG ATTGCTAACT CCTGTTCCAG GATTTCCAGT CAAACAGACA AAGTCAAAAC 1080

CTAACTCCTA TATTCGCTTC AATGTTTCAA CACTAGCAAC ACGACCTGCA ACAATTTCCT 1140

GTGTTTCCTC TAGCATTCTT TGCAGATGGG TCAATCGGTT CCAAATTTAC ACCAATTGGA 1200

CAAGCAACAA G 1211

(2) INFORMATION FOR SEQ ID NO: 62:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1425 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:62:

CCACACTAGC AGCCTATGGA CTCACTAAAA GAAAAGAAGA CTAAGTCTTT TCGATAAAAA 60

ATAAACAGCG AGATTGAAGC TCGCTGTTTA TTTTTTAATT AATCACCTAG TCCAAGACGT 120

TCAAAGATAT CATCCACTCG TTTGGTGTAA TAAACTGGGT TGAAGATTTC ATCGATTTCT 180

TCTTGTGTGA GACGTGATGT TACTTCTGAA TCTGCCTCAA GAAGTGGTTT AAAGTCTACT 240

TGGTTGTCCC AAGAGTAGGC TGTTTTTGGT TGCACCAAGT CATAGGCTTG CTCACGGGTC 300

ATGCCTTTTT CAATCAATGT CAACATAGCC CGTTGGCTAA AGATAAGACC AAAAGTCGAG 360

TTCATGTTTC GGATCATATT TTCTGGGAAG ACTGTCAAGT TCTTGACGAT ATTTCCAAAA 420

CGGTTGAGCA TGTAGTCAAT CAAAATGGTC GTATCTGGTG TGATGATACG CTCAGCTGAT 480

GAGTGAGAAA TATCGCGTTC GTGCCAGAGA GCGACGTTTT CATAAGCCGT AATCATGTGA 5 0

CCACGAATGA CACGCGCCAG ACCAGTCATA TTTTCAGAAC CGATTGGGTT GCGTTTGTGA 600

GGCATTGCTG AAGACCCTTT TTGCCCTTTA GCAAAGAACT CTTCTACTTC GCGTTGCTCA 660

GATTTTTGTA GACCACGAAT CTCAGTCGCC A ACGTTCGA TTGAAGTCGC AATGCTGGCA 720

AGAACCGCAA AGTACTCAGC GTGAAGGTCA CGAGGAAGGA CTTGTGTTAA AGATTCCTTG 780

GGCACGGATG CCAAGTTTAT CGCAGACATA CTCCTCTACA AATGGTGGGA TATTGGCAAA 840

GTTCCCAACC GCACCAGAAA TCTTACCAGC TTCTACACCA GCAGCCGCAT GCTCGAAGCG 900

CTCCGATATT GCGTTTCATT TCGCTGTACC AAGTTGCTAA TTTAAGGACC AAAGGTTGTC 960

GGCTCAGCGT GCACACCATG AGTTACGCCC CATCATGATG GTGAACTTGT GCTCCTTGGC 1020

TTGTCAGCGA TGATATTAGT GAAGTTTTCA AGGTCACGAC GGATGATGTC GTTGGCCTGC 1080

TTGTAGAGGT AACCATAAGC AGTATCCACC ACGTCGGTAG AAGTTAACCC ATAGTGAACC 1140

CACTTGCGCT CTTCACCAAG AGTCTCAGAA ACCGCACGCG TGAAAGCCAC CACATCGTGG 1200

CGCGTCTCCT GCTCAATTTC CAAAATACGG TCGATGTCAA AGTCCGCCTT CTTGCGAATC 1260

AAAGCCACAT CTTCCTTAGG GATTTCCCCA ACTCAGCCCA TGCCTCGTCA GAGAGGATTT 1320

CCACCTCAAG CCAAGCACGG TATTTATTTT CTTCACTCCA AATATTCGCC ATCTCAGGGC 1380

GAGAGTAACG GTTGATCATG TGTTAATTTT TCCTTTCTTC TTAAG 1425

(2) INFORMATION FOR SEQ ID NO:63:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1124 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63:

CTATTCTGAG TATAAAGTTG GCGGAGGCTG GAACTACGCT CGTTATGAGG TCATAAACTA 60

CTATACTGGA GGTTATTAAT CCTTAAAGAG TGAGAAAAGG AGGGCTGGAT ATGTTAAATC 120

TTACTCATGT TACCTTAAAA ACGCGACAAG TCATCTTGCA AGATGCGGAT TTTACCTTTA 180 AAAAGGGTAG GATTTATGGC CTTCTTGCTA TCAATGGCTC GGGAAAGACG ACACTATTCC 240

GAGCTATGAG CAAGTTGCTT CCCCTTAGTA GTGGACACAT CGCAGTTCCT CCTTCTTTGT 300

TTTATTATGA GAGCGTTGAA TGGCTGGATG GAAACTTAAG TGGGATGGAC TACCTTCGTC 360

TCATAAAAAA ACATCTGGAA GTCAGACCTA AACTTGAGAG ATGAAATCGC CTACTGGGAA 420

ATGGCTGACT ATATCAGTCT TCCCATCCGC AAGTATTCCT TAGGGATGAA GCAACGCTTG 480

GTGATTGCTA TGTATTTTCT CAGTCAGGCC AAATGCTGGC TCATGGATGA GATTACAAAT 540

GGCTTAGACG AGTATTATAG ACAGAAGTTT TTTGATAGGC TAGCACAAAT CGATAGACAA 600

GAACAGCTGG TTCTTTTAAG TTCCCACTAT AAGGAAGAGT TGGTTGATAT CTGCGATAGA 660

GTAGTAACCA TTCATCAGGG GCAGATAGAA GAGGTTTAGT TTATGAAAGA TGTTAGTCTA 720

TTTTTATTGA AAAAAGTTTT CAAAAGTCGT TTAAACTGGA TTATCTTACT TTTATTTGCA 780

TCTGTACTCG GTGTTACCTT TTATTTAAAT AGTCAGACTG CAAACTCAGT CAGCTTGGAG 840

AGAGAGTTGG AAACTCGTCT TGTAGACCGT GAGAGAGTCA TCAATGAAAA TGAAGAGAAA 900

CTCTCCCAAA TGTCTGATAC CAGCTCGGAG GAATACCAGT TTGCTAAAAA TAATTTAGAC 960

GTGCAAAAAA ATCTTTTGAC GCGAAAGACA GAAATTCTGA CTTTATTAAA AGAAGGGCGC 1020

TGGAAAGAGG CCTACTATCT GCAGTGGCAA GATGAAGAGA AGAATTATGA ATTTGTATCA 1080

AATGACCCGA CTGCTAGCTC TGGCTTAAAA ATGGGGGTTG ACCG 1124

(2) INFORMATION FOR SEQ ID NO: 64:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1089 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64:

CAGAGCAACT TCGTCAAATC TTCATAGGTG AGGTAACCAA TTGGAAAGAG GTTGGTGGTA 60

AGGACTNACC CATCTCTGTT ATCAATCGGG CAGCCGGCTC TGGCTCTCGT GCTACCTTTG 120

ATACTGTCAT TATGGAAGGT CAGTCTGCCA TGCAAAGTCA GGAGCAGGAT TCAAATGGAG 180

CGGTAAAATC AATCGTATCA AACAAGTCCA GGAGCTATCT CTTATTTATC TCTTACCTAT 240

ATAGATGATT CGGTCAAAAG CATGAAGTTG AATGGCTATG ACTTAAGTCC AGAAAATATA 300

AGTAGCAATA ATTGACCCTT GTGGTCT AT GAGCATATGT ATACATTGGG GCAGCCCAAT 360

GAGTTGGCTG CAGAATTTCT CAATTTTGTT CTCTCGGATG AGACCCAAGA AGGGATTGTC 420

AAAGGATTGA AGTATATTCC GATTAAGGAA ATGAAGGTTG AAAAAGATGC TGCCGGAACT 480

GTGACAGTGT TGGAAGGGAG ACAATAATGA ATCAAGAAGA AT AGCTAAG AAAATGTTGC 540

TTCCATCAAA GAATTCTCGT CTGGAGAAAT TAGGAAAAGG TTTGACCTTT GCCTGTCTTT 600

CTTTGATAGT CATCCTTGTG GCCATGATTT TGGTTTTCGT AGCGCAAAAA GGCTTGTCGA 660

CCTTCTTTGT CAATGGTGTG AATATCTTTG ACTTTCTTTT GGGAGGAACT TGGAATCCTT 720

CTAGTAAAGA ATTTGGTGCC CTTCCTATGA TTTTGGGTTC CTTTATCGTT ACCATTCTCT 780

CAGCCCTTAT CGCAACACCC TTTGCTATTG GTGCAGCAGT TTTTATGACC GAAGTATCAC 840

CAAAAGGGGC GAAGATTTTG CAACCAGCTA TTGAACTCCT GGTTGGGATT CCTTCAGTAG 900 TGTACGGATT TATTGGCTTG CAAGTCGTCG TTCCCTTTQT TCGCAGTGTC TTTGGTGGGA 960

CTGGTTTTGG GATTTTGTCA GGGATTTCCG TCCTCTTTGT CATGATTTTG CCGACCGTAA 1020

CCTTTATGAC AACGGATAGC TTGCGTGCGG TTCCTCCNTT ATTATCGTGA AGCCAGTTTC 1080

GCTATGGGA 1089

(2) INFORMATION FOR SEQ ID NO:65:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1502 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 65:

CTNTNTTTAA ACCTTGACCT TANTTGANNA TTATACCGAA ATTNTCTTCA TTTTTAAAAG 60

AAAAAAGGGC GCTGGTAAAA GGGATAATCT TCACCAACTC CCTATNTTTC TACTTATCTA 120

AGCCTAATTC TGCCAAGATT TGACGTTTGT NGGCAATCTT TNGGACTTCN TNGTCCTCAT 180

CTTCAGACCA GTCTAGTTTA ATTTCTGAAA CAATCTGCCC AGGGNGATTT NTCAAGATAT 240

AGATGCGGTC GCTGAGANTG AGGGCCTCCT CAATACTATG CGTGANGATC AGGGTTGTTA 300

GCTGCAACTG CTTGTGAATC TCAAGATACC AAGCGTGGAG TTCCATCTTT GTCATCTCAT 360

CCAAGGCGCT AAAGGCCTCA TCTAAGAGAA AGAGCTTGTG CCCAAAAAGG TAGGTCCGGA 420

GTAAGGCTAC ACGCTGGCGC ATCCCACCGC TAAGTTCATG AGGATACTTG TCTCTTACAG 480

CTGTCAGCTG GAAGGTCGCA AGAATTTTAT CCGCTCGGGA AATAGCTTCT GCCTTATCCA 540

CCTTTTGAAT CAAGAGGGGC AGAATGATAT TTCCAAGCAC CGTCTTGTGC TCCAAGAGCA 600

GATCCTTTTG CAACATATAA CTCACGTGCC CCTTGGGATT TTCTTCACCA TCAAGGACAA 660

TTCTCCCTGA CTGAACTTCT AAAATCCCAG CGATTAGATT AAAGAGGGTG GTCTTTCCAA 720

CACCACTTGG GCCTAGGATG GAAACCACTT CGCCTGAAGT CACCTGTAGG TTGATATCCT 780

CTAAAATCCT CTCCTGACCA TAGGCATAAC TGACGTGCTC TAGTCTAATT TCTGTCATTA 840

TTTCACAAAT TCGTTGGTGA AGCCTTTGTC TGTCAAGTCT TCTTTAAGGA TACCATTTTC 900

TTTATCCCAT TTATAGAAAG CATTCCAGCG AGCTGCGTCA AATTGACCCC ATTTTTCCTT 960

GTCGCTTGCG TATTCTTTTG ACAAGTATTT TTGAGATTCG ATGACAAAGT CACGTTTTTC 1020

CTTGAGTTCA GGTGCATTCT TGATGAGAAT ATCTGCAGCT TCTNCTGGAT GTTCCATGGC 1080

ATATTGGTAG CCTTTTNTGA TGGCTTGGAT GACTTTGCGA GCTTCTTCTT TGTTATCTTT 1140

CAGATAGTCG TTGTTTGCGA TGATAACTGG TGAATATTAN TCAAACTCCT TGACATAGTC 1200

TTTCAANTAC ATGAAGTTAG CATCTACACC TTGAGATTTA GCAAGGATAC CATCCCAACC 1260

GTAGTAAATC CNAGCAGTAT CAAAGACGCC ATTGGCAATC GGTGTGATTG AGTTTGAGTC 1320

NTTANTTGGT ACTNTTTCAA CCTTCTCACA GTCTCCNCCT TGAGATTCTA CCAAGGTTTT 1380

CAACATACNN GTTCANTTGG GTCATTCCAT GTCCCATATT TCTTACCAAC CAAGTCTTTT 1440

GGACTGCCTA CATTNTCACA TTACCGAGAG ATGATCCCTG ATGTATTGTG TTCCACCNAT 1500

AG 1502 (2) INFORMATION FOR SEQ ID NO: 66:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1022 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:66:

ACTCTTCAGC GATTTCTTGG CTGAGAATGT CCTCATAGGC AGGGAGTTGG ATGTCCTGAC 60

CAT TTTCTT CTTGAGGGCA GTAGTAACTA GGCGATAAGC CAGATTGGCA TTACGAGAGA 120

AGATAGGCCC GNGGAANTAC GAACCAAAGA CATTCTTATA ATGAACCCCT TCACCGACCT 180

TTTCTTCGTT GTTTCCATTT CCATAGACAA CCTGTCCCAG CGGTTTTTGG TCATCAGAGA 240

GGAAGGTACG ACCTTGGTGA TTTTCAAATC CATAGTAGGT TTCATCGAAA TCTTTCATTG 300

TGAATCTTGA TGTCACCGAT AAAACGGTTA TTGGTCTGGT TGAGCGTGTA GTGTCCCATG 360

ACCCCTAGCC CTTCGATACG TTTTCCTGAA GCTTCAACAT AATATTGACC CAATAGTTGG 420

AAACCACCGC AGATAGCCAG AACTACACCG TCGTTTTGGA TGTAGTTGTC AATGCTCTCT 480

TTTTTAGCAG GTAGGTCGTC TGCAATGATA CTTTGTTCAA AGTCTTGACC ACCACCGAAA 540

AAGGCGATGT CGTAGTGATT TTCATCAAAG TCATCATGGA GAGAAACGAT GTCAACGGTC 600

ACATGGGTTC CCAGTTTTTC AGCCACATAC TTGAGCATGA GGATGTTTCC ATTGTCCCCG 660

TAGGTATTCA TGAGATTTCC GTAGAGGTGG GCAATGTTGA GCTGATAGGG GTAATTGCCA 720

TCTTTTGAGG AAAGTGAAGT ATAAACCATT AGTTCATCTC CTTTCTAACA ATCTGACGAC 780

TAGCCAGCAG TTCACGAAAT TCCAGCATGG CAGTATAAGT TGCCAGAATA TAGGCATGCT 840

TGCAGTCTTG ATTCTCAATG GTCTTGAGAA CTTGCTCCAG ATTACTCGTT TCAGTGATTT 900

TCTCAGCTGG ATAGCCAGTC ACTCGGAGGC GACGAGCGAT TTCAGAATGA CGAACACCGC 960

CAGCGTTGAT TTCAGGAATG TCCATGTCAG TGATTTGCTC AAAGTCTGCA TCCCAGATCC 1020

AG 1022

(2) INFORMATION FOR SEQ ID NO:67:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1353 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67:

CCTCCAGGTC TCGGGAAACG ACCATGGCCT TTGTTATTGC CAACGAACTG GGAGTCAATC 60 TTAAGCAGAC GTCGGGTCCA GTCATTGAAA AAGCCGGAGA TCTGGTAGCT ATTTTGAATG 120

AGTTAGATCC TGGGGATGTA CTTTTTATTG ATGAGATCCA TCGTTTGCCA ATGTCAGTGG 180

AAGAGGTGCT TTATAGTGCT ATGGAGGACT TCTACATAGA TATTATGATT GGGGCTGGTG 240

AGGGTAGTCG TAGTGTTCAT TTGGAGTTAC CACCTTTTAC CTTGATTGGT GCGACGACTC 300

GGGCTGGTAT GCTCTCCAAT CCGCTACGGG CACGTTTTGG GATTACAGGC CATATGGAGT 360

ATTATGCCCA TGCTGACTTG ACAGAAATTG TCGAGCGGAC GGCAGATATT TTTGAGATGG 420

AAATCACTCA TGAGGCAGCA TCTGAGTTGG CCCTACGTAG TCGTGGGACC CCTCGTATTG 80

CCAATCGTCT CCTCAAGCGC GTGCGCGATT TTGCCCAGAT AATGGGGAAT GGGGTAATTG 540

ATGATATTAT TACCGATAAG GCTTTGACTA TGCTGGATGT TGACCATGAA GGTTTGGACT 600

ATGTGGATCA AAAAATCCTT CGTACCATGA TTGAGATGTA CAGTGGAGGA CCTGTTGGTC 660

TAGGAACTCT TTCTGTTGAA TATCGCCGAA GAACGTGAGA CAGTTGAAGA TATGTATGAG 720

CCTTACTTTG ATTCAAAAAG GTTTTATCCA TGCGGACACC GTCCTGGACG GGTGGCGACT 780

GCCTAAGGCA TATGAGCACT TAGGTTATGA ATACAGTGAA AAATAAGCAA GAAATCCTTA 840

GAGGCTTTTT AGAGAAAATC CAGATATGAT GGCCATTCTG ACGATCATCC GAGACCTTGG 900

TCTGAAAGAC TCGTGGTTGG CAGCAGGTTC TGTCAGAAAT TTCATTTGGA ATCTTTTGTC 960

AGACAAATCC CCTTTTGATC ATGAAACAGA TATAGATGTT GATTTTCTTT GATCCCAGAT 1020

TTTTCTTATG AGGAAACCTT ATTACTGGAG AAAAAGCTGT GAGAGGATTT TCCTCAGTAC 1080

CAGTGGGAAT TGAAAAATCA GGTCTATATG CATCAGCACA GTCCTCACAC TGCTTCCTAT 1140

ACCAGTTCTC GTGATGCTAT GAGTAAGTAT CCAGAACGGT GTACGACAGT TGGACTGCGC 1200

TTGAATGAAG AATCAGATTT TGAACTCTAT GCACCTTATG GTTTGGAGGA TATTTTGAAT 1260

TTCAAGTTCG TCCAACTCCT CATTTCTTAG AAAATGAAGA CCGAATGGAA CTCTATCAAA 1320

CACGTT ATC CAAGAAAAAT TGGCAGGAGA AAT 1353

(2) INFORMATION FOR SEQ ID NO: 68:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 560 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:68:

CTCCTGGAAA TTCTGGCAAG TAGGCTGGAT GAATGTTGAC AATCCGACCT TCATAAGCCG 60

ACAATAAGGT TGGTCCAACG ATTTTCATGT AGCCTGCTAG GCAAACCAAG TCAATCTGGT 120

GTTCTTCCAA GAGTTCGACA AGGGCTGCTT CGTAGTCTGT CTTGCTCTCA AACTCCTTGA 180

GTTCAAAAGC ATAGGACAGA ACGCCGAGCT GCTTTGCACG CTCAAGCACA TAGGCATCAC 240

GATGGTCTGA AAAGACAAAC TCCACTGGAA ATTCTTCGGC AATCACCTGA AAATTTGAGC 300

CATTACCAGA GGCAAAAACC GCTATTTTTT TCATTTGATA ATGACACTTT CGTTTTCTTT 360

CTTGACGATG CGACCAATTT CATAGACTGC TTCATCCAAC AATTCTTTTA CACGCTCTAC 420

ATTTTCAGGG CTGACCGCCA ACATAAGTCC CACACCCATA TTGAAGATTT CAAACATTTC 480

TTCGTGTTTA ATCTGACCAT ATTTTTCAAG GGCTTTGAAA ATTGGAAGCA CTGGAACTTT 540 GCTTTCATCA ATTTCAGCAG 560

(2) INFORMATION FOR SEQ ID NO: 69:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 860 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:69:

CTTCAACACT TTATTTTTAT CTTTCTCCCA TTTCGTATGC TAGTTCGGAA ATTGTTGCTA 60

GAACCTCTCC GACTATTTGG GATGTTCTCA TTGCTTTTGT AGGAGGGATA GCAGGTATTA 120

TTGGTGCTAG GAAAAAAGAG ACCAATAATA TTGTTCCTGG TGTTGCTATT GCAACCGCCT 180

TGATGCCTCC TCTTTG ACA GTAGGTTATG CTATTGCTTC TGCTAATCTA AAATTTATCA 240

TTAGGCTCCT CTTACCTATT CCTCATCAAT TGTAGCTTTA TTGTCATTGC GACTTATATA 300

GGTGTTAGGT TGATGATGGT TAAGAAACAT TATTTTAAAG ATAATGAAGA AGACTCTAAA 360

ATGCGTAGGA TTTTGCTTCT AGTTGCTGTT TTGCTGATGA TTCCGAGTTT CATCTCTGCA 420

ACGACTTTAG TGAGAGAAAC GTTGAAAAAA GAGTCCCTTA AGAAATT AT ATCAGAGCAG 480

TTTCAGGGGC ATAATATTTT GAAAAAAACC TATTCTAAAA AGACTCATAC CCTAAAGCTA 540

ACCATTTCAG GAAATTATTT GACAGAAGAA GAACTCGATA TGATTTCAAG TAAGAGAGGT 600

GACTATGGTT TAAGTGATGT TTCTGTTCAA GTTTCACAAT TGTCTGATTC AGAACAACTT 660

AGTAAGGAAG AACTGGTGGA GTATTTCTTC CAGTATATCA AGGATAAGGA AGCAAAAGAA 720

AAGGAAAAAG CTAATAAGTT TTATACAGAG TCTGAGGAGC AATAATTTCT TGAGAATAGC 780

TGGTTTTTCT CGTGAGTCTT CTATGTATAT CAAAGGAAGA CTGAGGTTTT AAGTATGAAA 840

CTTTTCTTCT ATTATAGTAG 860

(2) INFORMATION FOR SEQ ID NO:70:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 925 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:70:

TCTTGGCCAA CTGCATGGAG TTCAGCGGTC AATTTCAACG CACCTGAGAA ACAGACCCCT 60 GCACCCCTGA AATCTCAGGA GACATGATGG TCTGGATGGA ATCAATAATG AGAAAGTCTG 120 GCTGGATACG CTACCACTTC TGCACGAACA CTCTGCATAT TGGTCTCTGC ATAGAGATAA 180

AACTCACTAT CAAAATCACC TAAGCGCTCT GCACGTAGTT TAATCTGCTG GGCAGACTCC 240

TCCCCACTGA CATAGAGAAC TGTCCCCACT TGGGACAACT GGGTTGAGAC TTGTAGGAGA 300

AGAGTTGATT TCCCAATCCC AGGATCCCCA CCGATGAGGA CGAGACTTTC CTGGTACAAC 360

TCCGCCTCCA AGCACACGGT TGAATTCCTC CATCTCCGTC TTGGTTCGAT TGACATTGAT 420

GGAAGTCACC TCAGCTAGTT TCATGGGCTT GGTTTTCTCA CCTGTCAAGG ACACACGCGC 480

ATTCTTGACC TCGGCAACCT CAACCTCTTC CACAAAAGAA GACCAAGACC CACAGTTGGG 540

GCAACGTCCC AGATATTTAG GGGAATTATA CCCACAATTT TGACATACAA ATGTCGCTTT 600

TTTCTTTGCG ATGACAAACC TCTTTCTATA TCTCTAACTC ACACTCAATC ACTTGGCAAA 660

AATCAATCTT CTCATTTGGC ACAAACTGGC GCATGAGCAT TCGATGAGCA ACAACTACCA 720

CAGTCTGATG TTCTCGATAC TTAAACATAC ATTCTAGAAA CCGAGACTTC ATTTCCGTAG 780

CTGTCTCATA TTGAATAGGA CTATTAGGAA GCAACTCCCC CTTGTTTTCT AAAAACAGTC 840

TTCTAGCTGT TTCAAAGTTT TCTATTCCTG TTTTATAGAC CTGCCATTCA TGTAATAAAG 900

GCTCTACTCT TAAAGGAAGA CCCGT 925

(2) INFORMATION FOR SEQ ID NO:71:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 630 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:71:

TTCTNGATCA AGTCAAGGAC TGCANGCCAC GACCGACATA GCGTTTGGCA ATGGAAACAA 60

CCAAACGAAG ATTGGCTTCC GCAAGACGTT GTTTGGCTTC GATATCGCCA GCTTCAACAG 120

CCAGTGCCAA CTCTTTCTCC TCTTCATTGG TCAAGAGAGG AACGACCCCT ATTTCTTTCA 180

AGTACATACG GACAGGGTCA TTGACCTTAG CAGAAGTTGA CCCAATCAAG TCCTCATCGC 240

TGAGTTCTGG TTCTTCTTCA TTGCTAAGAA CACGCGCACT TGGATTTCCT TCGTTATCTG 300

TGATAGAAAT GCCTGCATCC TGAATCCGTT GCAAGAGATC TTCAATCCCA TCAGCGTCCA 360

AGGTAAAAGG AATAACCAGA CTTGCATTGA TTTCATCATC TGTTGCTGTC CCTTTTTGCT 420

TATGATTACG GATAAATTCT GCTACCTGTA CGTCAAATGT TGTTACTTCT TTTTGTTTTG 480

TTGCCATTAT TACTCCATTC TTCTCTTTTG GGAAATTAAA CGTTCCAATT CTTCTAGGGC 540

TGTATCTGTA TCTCCTACAT GGCTAGCTTC CTGCACCTTC TTTTTGATTC CCATATTGTC 600

CTGATTCAAG AGAGCCTTGT TTCGAAGTCA 630

(2) INFORMATION FOR SEQ ID NO:72:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 849 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: 1inear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:72:

CTAGGGCCAT CTTCTCACCT CCTCCTTGTC AGTACATTCT TGCAATAGAA AAAATAAGAT 60

TGAGTCCCCC CAACCTTAAA TTTTTTCACC ATCTTCTTTT TCTTTAGCAA TTTGCTCTTT 120

GATTTTCTTT TCTTCTTCTT CTTTGCGGCG TTTTTCTTCT TCGATACGGC GACGCACTGC 180

TTCACGTTTT CCTTCTGGAT CTGGGTGAAT TGTAACGTTT CCTGATTCGA TTTCTTCTAA 240

AGCGCGAAGA GTTGATTTTT CAGACTTGAA ACCTTGAGTT GCTGGGGCAC CTGCTTCCAA 300

TTCGTGGGCA CGTTTTGCTT CCAAGATTAC GAGTGAATAT TTTGAAGGAA CCTTGTCGAG 360

CAAGGTATCA ATAGAGGGTT TTAACATCAT TTGCTTGTAC CTATTTTCTA AATTTTATCG 420

GGTAGTTGGA GATTTTGGTA ACATCTCCTG ATAGTGACCA ATGACACGAT CCACACAGAA 480

GTGTTCTGCT TCAATCACAC ATTTGACACG TTCAGCAGCT AGGGGTACCT GATCGTTGAC 540

AATCGCATAA TCATACTCAC GCATGAGGGC AATTTCTTCC TTGGCCTTTT CGATTCGTTG 600

GGCAATCACT TCTGCACTAT CTGTTCCACG ACCTACCAAG CGTTCTTGCA ATTCATCCAA 660

ATCTGGTGGT GTCAGGAAGA TAAAGACAGC ATCTGGAACC TTTTTCTTGA CCTGAAGAGC 720

ACCCTGAACT TCAATTTCAA GGAAAACATC GATTCCCTTG TCCAAGGTTT CATTGACATA 780

GGTCAGAGGA GTTCCATAGT AGTTGCCGAC ATATTCTGCG TATTCCAACA TCTGTCCTTG 840

ACGAATCAG 849

(2) INFORMATION FOR SEQ ID NO:73:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 581 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:73:

GCCAAACAAC GCATCCATAA TGGTTAAATC TTGATAAGGC AGAGCTACAT TCAAAACAGC 60

TTGCTGGTTT GTAGGCTTTC AATCAGAGCA ATCACTTCTT CAACCTTGTC AGCATCAAGA 120

GCAGCTGTCT CAATCTTTGT ACTTGTTTTG CCTTCCAGTT TAGCTTTCAA GTCATCGCAT 180

TTTGACTTGG TACGGCTAGC AATCATAATC TCTGTAAATG TTTCGCTATC TTGACAAATC 240

TTTGAAATAG CAACTTGGGC AACGCCCCCA CAACCAATAA CTAGTAAACG ACTCATTTTT 300

TTCCTTCCTC TTCTTCTAAA ATGTCCTCAA CATACTTGGG CAACATAAAG GCTCCCACGT 360

GTAAGTTTGC AGTGTAGTAT TCTGTGAAAA GCTGGCGTTT TTTCCAGCCT TCCTTGTCAA 420

AATCTTTGAC AGGGTGGTAT TTTTTCGATG CAAATCCAAA CAACCAATAG CCAGCTGGGC 480

TAGTTGGAAT ATGGGCCTGA TAAACCCGAC TGATTGGAAA GGCTTGATTG ACCTTGCGGT 540 GCATGCTTCG GCAGGCCGAC TCATCCTCGT CAAAGAAAGG A 581

(2) INFORMATION FOR SEQ ID NO:74:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:74:

TTCTGAAAAT CCATACTTCT ACCAAGGAGA TACGCTAGCG GTCTCGGAAG TTCTCATACT 60

TCTATCGCTA TATCTGGCCA TCGCCTTTCT ATCCAAGGAT TGACAACAAG AGATAAGGCA 120

GAGAAAAAAT TCTTGCTGGA TCAGCTGGTT GCCTGCGATG GTGGTACAGG TGTCATGCAC 180

GAAAGCTTCC ATGTAGATGA TCCGACCCTC TACTCTCGTG AATGGTTCTC CTGGGCTAAC 240

ATGATGTTCT GTGAGTTGGT CTTGGATTAC TTGGATATTC GCTAAGGGGC TCGCTTTAGC 300

TCAACCGATT CTTATCAGAA TCACAAGTTT ACATTTAAAA CGTTAAAATT TAAATTTAGA 360

ATGAGGTTTT ACTTCATGGA AAATGTTGTT GTACATATTA TCTCACATAG CCACTGGGAT 420

CGTGAGTGGT ACTTGCCTTT TGAAAGCCAT CGTATGCAAT TGGTGGAATT GTTTGACAAT 480

CTCTTTGATC TCTTTGAAAA TGACCCTGAG TTCAAGAGTT TCCACTTGGA TGGACAAACT 540

ATTGTCCTTG ACGACTAACT TACAAATTCG CCCTGAAAAT CGCGACAAGG TCCAACGCTA 600

CATTGACGAG GGCAAGCTTA AAATTGGTCC CTTTTACATC TTGCAGGATG ATTATTTGAT 660

CTCCAGTGAA GCCAATGTCC GCAATACCTT GATTGGTCAA CAAGAAGCTG CCAAATGGGG 720

TAAATCAACC CAGATTGGCT ACTTTCCAGA TACCTTTGGA AATATGGGAC AAGCGCCTCA 780

AATTCTTCAA AAATCAGGCA TTCACGTGGC GGCCTTTGGT CGTGGTGTGA AGCCGATTGG 840

ATTTGACAAC CAAGTCCTTG AAGATGAGCA GTTTACGTCT CAGTTTTCAG AAATGTACTG 900

GCAGGGTGTG GATGGTAGTC GTGTTTTAGG TATTCTCTTT GCCAACTGGT ACAGTAACGG 960

GAATGAAATT CCAGTTGACA AAGATGAGGC CTTGACCTTC TGGAAACAAA AATTGTCAGA 1020

TGTGCGTTGC CTACGCTTCG ACCAACCAAT GGTTGATGAT GAAACGGCTG TGAACACCAG 1080

CCTGTCCCAA AAAAAATCTG AGCGAAGCCA TTCCGTGTGG CAAATGAACT CTTCCCGGAT 1140

GTAATCTTTG TTCATAGTTC TTTTGATGAA TATGTTCAAG 1180

(2) INFORMATION FOR SEQ ID NO: 75:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 579 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75:

CTCAAAAAGT CTGAAATTGG ATCATTTGGA ACCATCTGAG CAGTAAGTTT AACACCTTTT 60

TCTGCCAGTT TGTGGAAGTC TTCCACATCC TTGTCTACTA CGTTGATAGA ACGTGTAATA 120

GAACGAGTTT CTGGTGTTTG AGACATATTC CCAACATTAA GGGTTTCAAG TGGTACACCT 180

GCTTCTACCA AACCAAGGGA AGCGGTCTGG TTTACGAGCC ACGATAAAGA GACGTTGGCT 240

ATCGTATTTG CCAGCAAGAA TATTGGCTGC AGCTTTCTCA ACTGGCAAAA TACTCAATTT 300

CACACCTGGT GGTGTCGCAA GTTTCAAACC ACTCTTTTCA ATATCGTTGT TGACAACTTC 360

GTCGTCTACA ACCATAATGC GTGAAACATT TAGTTTTCCA GCCCAAAGAT TGGCTACTTG 420

TCCGTGGATC AAACGTCCAT CAATACGGCA TCCTACAATT GTCATAAGTT TTCCCCCTTT 480

ATATGTTTTA GTGTAGGTTT ACGAGTTAAA TGAATCTCTT CTTTATATTG ACCTTCTGTT 540

TCAAAGATAA TGATGCGGTT GGCACCTTCC TTGAGATAG 579

(2) INFORMATION FOR SEQ ID NO:76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 736 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:76:

CGCATANCCT AAAAGTTTTC TTTGACATCT TCTGGAATAT CTGTATCATT AGCTTCCTGA 60

ACATCTCTAC CATAAATCCC AAAGGCTGGA ATCCCTTTTT GAGCATGTGA AGCTAGTACA 120

GCTGCAAGAT AGACAGCTCC TGGGCGTTCT GTCCCATTAA ATCCCCAAAT AGCATGAGGA 180

ATATCTGGAG ACATATCCAT AGTTTCACTA CCATAACACC AGCATGGTGT AACTGTAATT 240

GTTGCGCAAA CATTTGATTT TTTAAACAAC TCATGGGAAG CTGCAGCCTC TGGAACACGA 300

CCAATGGTAG ATGGAGAAAT CACACATTCC ACAGGTTCCC CATCTGGATA TTTCAATGTG 360

CTTGAAATCA AATCTGCCAC ACTTTTAGCC ATGTTCATTG TTTGTACTTC AAGTGATTCG 420

CGTACACCTT GACGACGACC ATCAATAGTC GGACGAATCC CAATACGTGG ATGTTGAATC 480

ATACTATTTT CCTCTTATTT TTCTGTTTCT TTCATACTAC CATCGCCATT ATATTTACGG 540

TAGCCTGGGT GACGACCTGT AACCTTATAA TTTTCTCGCA TTGAGAATAG ACGTTCTAAA 600

GTCGGACGAG CAATTTCTTG CTCCTCAATG CCCTTTGTAG AAAGTAACAT TCTTCCGTGG 660

AAGGTTGTCT TTGCGACTAA TTCTAAAGTT TCCATACGGT AGTATGCTGT AATTACATCG 720

CTTCCGACAG TCAGAG 736

(2) INFORMATION FOR SEQ ID NO: 77:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 590 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:77:

CTCATTGTAT TTAGGAGAAA TGATGGTATC TTCCAAATCA AAATCAACTT CACTCCATAG 60

TCTCAACGGA TTGATTTTCC CATCTTGATA GGTCACATCC TTGTCAAGGA TAAACTGAGT 120

CAACGCCTCA TGCTGACCTT GACACCTGAT GTCATCTACC AAGAGCCAGA CATCCTCTAC 180

CAACATGAGG ATTTTTCTCT TGTGAAGATA AGGCAAATCA GGTTCTGCTG ACCAATAAGC 240

CCCTTCAATA TAATGCATTC CCTCCCTTTC TTTATGGTGA CAAAACAGGG AGTGAGGATA 300

GTATTCATAT TCCCAGGATC CCGTGATTCT TTCCGGAGCT TTCCCATCTA CAATGCAGGT 360

CGAATGACTC CAAGCACTCT TTAAGAGATA ACGTTCATAT ATCTCCCGAT AAGAATAACG 420

CCCAGCATCT ATGAAAATAG GTTGGCCTTG ATACTGTAAG CAAAAACTAT TCTCGTCACT 480

ATGGCTATGG GCACTTCCTA GCGGACCATT TTTGAAAAAT AGATAACGAT GTTCATCCTT 540

AATGCAGACA TGTCCAGAGT CTTCAAAGAT CATGGACTTA GGCTGCCAAG 590

(2) INFORMATION FOR SEQ ID NO:78:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1199 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:78:

CTAGTGTAGC TTCCTTAATC TTATCTGATA AGATAGCTGT CATATCAGAC TCAATCATTT 60

CCTGGAGCAA TCACATTGAC TCGTATATTC CGACTAGCGA CCTCGCGTGC CACAGACTTG 120

GTAAAGCCAA TCAAGCCAGC CTTAGAAGCA GCATAGTTAG CTTGACCAAT ATTCCCCATC 180

AAACCAACAA CACTAGACAT ATTAATGATA GCACCTTCTC TGGCTTTCAA TCATCGGTTT 240

CCAAAGACTG ATTGTGTCAT ATTAAAGGCA CCAGTCAGAT TGACCTTGAG CACTTTTTCA 300

AAATCTGCTT CTGTCATCTT GAGCATAAGA GTATCTTGGG TAATCCCTGC ATTGTTGACC 360

AAAACATCTA CTGAACCCAG TTCTGCAATA GCTTGATCAA TCATACGCTT AGCGTCTGCA 420

AAATCTGATA CATCTCCTGA AATGGGAACC ACCTTGATAC CATAGTTTGA AAACTCAGCG 480

AGCAATTCTT CTGAGATTGC CCCACGACTG TTT AGACAA TGTTGGCTCC TGCTTGAGCA 540

AACTTGTGGG CGATGGCAAG ACCAATTCCA CGACTCGAAC CTGTAA AAA GATATTTTTA 600

TGTTCTAGTT TCATTTTTTT CCTTTCAAAA CTTCTACTTA TTTTAGTCTA TTTTTCTAAA 660

AGTGCTACTA AACTCGCTTG ATCT CCACA TGAGCTAAGT GAGCAGTTTG ATCAATTTTT 720

TTAACAAAAC CTGACAAGAC TTTCCCCGGT CCAATCTCGA ATAAAGTTOC TTATGCCTGC 780 TTCTTGCATG ACCCCAATAC TTTCATAGAA ACGAACGGGT TCCTTGACCT GACGCGTCAA 840

GAGCTGAGCA ATGTCCTCTT TTTGCATCAC AGCAGCTTCT GTATTGCCGA CTAGGGGACA 900

AGTAAAATCT GAAAAACTTA CCTGAGCTAG AGTTTCAGCT AGTTTCTGGC TAGCAGGCTC 960

AAGGAGAGCG GTGTGAAAGG GACCTGACAC CTTAAGAGGA ATCAAGCGTT TGGCACCTGC 1020

TTCTTGCAAA AGTTCAACCG CTCGATCAAC TGCAACCACT TCTCCAGCAA TGACGATTTG 1080

TGCAGGTGTG TTATAGTTGG CTGGAGTAAC CACTCCAAGT TCCAGAAGCT TTTTGACAGG 1140

CTTCTTCAAT GACCTCTACT GGCGTATTGA GAACTGCTAC CATCTTGCCA AGTTCAGCA 1199

(2) INFORMATION FOR SEQ ID NO:79:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1414 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:79:

CTACTATTTT CTTTGCCATA GCCTTCTCCT TTACACACTA CGCATATCGT GGTAAGAAAC 60

ACTGCGTCCC ATCTCACCTG CATTCTCTTT TTGAACAAAG GTATTAGCGT TTATATAGGC 120

AATAGCAGAA GCCTTCAAC CATCAAAATC AAGCCCTGCT GCATTAAAGA TGGTTTCTGT 180

ATCCCTGTTT TCAACAGTGA CCAACAACCC GATCCTGGGC ATCGATTCCA TCTGTTACCG 240

CATTGATAGT GTAGGACACC AAACGAACAG ATTGGTTAAA GAACTTATCG ATAGCGTTAA 300

AGATTGCTTC AACGGAACCC TGTCCCTGTC GCATTAAATT CGACTTTCTC ACCATCCATA 360

TTGGCTAGGC TAACGAGCGC TTCAATGTCA TTATCTGCAT GAGTTTGAAG TTGTAAATCA 420

TCAAAGTGGA AGCCTTCTGG ATTTTCAACC ATGGTTCCAG CTACCAAAGC TCGAGTATCT 480

GCATCTGTGA TTTCTTACTT CTTATCGGCC AGTGCCTTGA ACTTAGCAAA GAATGGTTTG 540

ATATCCTCTT CTGTAAAATC TAAGGCCAAT TCTCTCAGTT TCTCAACAAA AGCATGGCGA 600

CCAGATAATT TTCCAAGCGG AATCTTAACA CCAACCAATT CAGGTGTGAT GATCTCATAA 660

GTGAGAGGAT TTTTAAGGAC TCCATCTTGG TGAATACCAG ATTCGTGGGA GAAGGTATTG 720

CCACCAACGA CGGCTTTGTT TTTAGGAACT GGAATACCAG AGAAGCGAGA AACCATTTCT 780

GACGTATTGA TGGTCTCATT TAGGACAATA CTGGTTTCTA CTTGGTAGTA ATCTTGGCGA 840

ATATTGAGAG CCACTGCAAT TTCTTCCAAA GCAGCATTTT CAGCTCGCTC CCTAATACCA 900

TGGATAGTCT CTTCAAAAAG TCCTGCACCA TTCTTGACAG CAGCAAGGCT ATTTGCCACT 960

GCCATCCGAA GTTCATCATG ACAGGGAGGC GAATAGATGA TCTGACGATC CGTCTGGAC 1020

TTCTCAATCA GGTATTGGAA GATGGCACCA CATTCCTCTG GTGTGGTAAA TCCTATATTT 1080

TCTGAAAATT TCTTCAGTAA AGAATATTTA GCTAATTGAA AGTTCATGAA AATTATTAAA 1140

ATATTTCATT TTTTAGAGGT TAAGTTCCAA CTTTTTTCTA TCAATTCCAG TACTTNTTCA 1200

TCTGATAAAG TATCATCAAG GGACACACTA ATCCAGTAGC GCTTGCTCAT ATGGAAGGCT 1260

GGATAAATCC CCTTTTGTGA AAGCAAATTA GCTACTTGGT CATGCTTGAG GTTGACTGCT 1320

TCCACTTGTC CTTCTCTGCC CTTTTCCAGC TTATTCCAAG AGATTTTCAN CAAGACGGCA 1380

TACCACTTTT GATTGCCTTC ATGGCGCAAT ACAG 1414 (2) INFORMATION FOR SEQ ID NO:80:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 750 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:80:

CTCCCCATTT TGGAAAATTT CTGTCAAGAA ACGGCGAACC AGCTTTTTAT TTTCTGCTTT 60

CTTGTCCAAA TCCTTGATTT CAAAATCTCC AAAAATTTGA TCTAGTTGGT CATTTTCAGG 120

TGTTCGATAG TAGTCAATGA CATCCCAATG CTCAACAATA CGACCATTCT CATCCGCACG 180

GAAAGTATCC GTCGTCACCC ATTGAGCTTC TCCACCATTC AGATATTGAT GGAACATGAA 240

CAAAGACCAG ATTGCCATCC TCAATGGTGC GGACAATCTT AATCTGACGC TCTGGATGAC 300

GCTCAAAGAA ATCTGCAAAG AAGGCTGCAA ATCCTTCTTT CCCGTCAGGA ACACCTGTCG 360

AATGTTGGAT ATAGGTATCC CCTACAGACT GGGCTTGAGC CTCAGCAACT CGTCCGTCTT 420

GAATGGCATG GATGTATAGG TTGTGAGCAT TTTTCACTTG TTGTGACATA TTCTAAACCT 80

CATTTCCCTT CTCTTTCAGA TTCGCCAAAA TTCTTTCTTG AAAACCTTCA AATTGGTGAA 540

TTTCTTCCTC TGAAAATCCT TTGTAAAAGA TAGTATCCAA TTTCTGACTG ACACGATGCC 600

CCACTTCTTT CTGGGACTTG CCTAACTCCG TTAAAACTAA ATACTTCTTA CGCTTGTCTT 660

TTCCACACGG ACTAACAATT ACAAGCTTTT GTTCCTCTAG CTTTTT ATC ATAGTCGTCA 720

GCGTATTATT CGCAAGCCCA GTCGCAAGCG 750

(2) INFORMATION FOR SEQ ID NO: 81:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 953 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:81:

GTATCGTTCA ATTCCAAAGA TACGGAGGAA GCTGCGTTTC GCGAGAAAAC TCTTGTTAGA 60

CCAGATAGGG ATTAGCCAAA ATCCTTCTAT GNGCTTATAT CCAAATGGAG ATGCAAACTT 120

CTGCCCAACT CTTGACCAAT AAGATCTTTC TTAAAAATCC ACTCAAGGCT CTGGTAGAGG 180

AAAAATATGG GATTGAGTAT GAAGAATTTA CCAATCCTTG GCACGCTGCC ATTTCTAGCT 240

TCGTTGCCTT TTTCCTTAGA AGTTTGCCTC CAATGCTGTC AGTGACCATA TTCCCAAGTG 300 AATATCGCAT CCCTGCTACT GTCCTTATTG TCGGTGTGGC CCTTCTTCTC ACTGGTTACA 360

CTAGTGCCAG ACTTGGAAAG GATCCGACTA GAACAGCTAT GATTCGGAAC CTTGCTATTG 420

GTCTCTTGAC CATGGGAGTT ACCTTCCTGC TCGAACAACT TTTCAGCATT TAGAATACAA 480

GAAATACCTC GATTTTGAAG TCGAGGTATC TTTTTTACAT TTGCACAATC TTGCGATAAC 540

TTCTTGAAGT AATCATGAAA ATCAGCACAT AGGCGATGAG GAAGATAGCG CAGATAGACA 600

AGGTCACAAT CAACATCATA GTCGTATCCA GTACACCAAT CACTTTTAAA ATCAGGCTAA 660

GCATATGGTA GGCAAAGGCG AGATGTATGA AGGCAAAGAG CAAAGGAAGG AAGAAAACAG 720

TTAAAACCTG TTTGTTGATG GTTTGCTTGA TTTGCTTTTG GTCCAAACCG ACTTTCTGCA 780

AGATAATAAA GCGTTCACGG TCTTCGTAGC CTTCAGAAAT TTGTTTGTAG TAGATGACCA 840

GAACAGTTCC GACCATAAAG ATAATGGATA GGAAAATACC GATAAAGAAG ACACCGCCAA 900

AGAGGACACT CATTTGAGCA CTAGCATCTG CTAGATTGCT ACCATAAACA TAG 953

(2) INFORMATION FOR SEQ ID NO: 82:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 665 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 82 :

CTGATTGAAC TTCTATTTAC TAATATTCAA AAATCCTCCG TTTCAAAGAG CAGGGAACTC 60

TTTGTGACAG AGGATTTTTT CTATAGGGCT TTAGCAGCTG CAATTGCGGC TTCGAAGTTT 120

GGCTCAGAAT TGATATTATC CACGTATTCA ACGTAGCGAA TCGTATTGTC AGTATCGAGG 180

ACAAAGACTG CGCGTGCTAA TAGGTGCCAT TCGTTGATCA AGAGGGCATA ATCGCGCCCG 240

AAAGAATGGT CAAAGTAGTC TGAAAGCATA ATGGCATTGT CAAGGCCTTC AGCACCGCAC 300

CAACGTTTTT GAGCAAAAGG TAGGTCCATT GAAACAGTCA ATACGACCGT GTTGTCCAGT 360

CCAGCCAATT CTTCATTAAA ACGACGTGTT TGAGTTGAGC AGATGCCTGT ATCGATAGAA 420

GGAACGACAC TCAAGACTTT TTTCTTGCCA TCAAAATCAG CCAGAGATTT TTTAGAAAGA 480

TCTGTTGTAG TAAGAGAAAA ATCAAGCGCC TTGTCGCCGA CTTGTAGTTG TTTACCTGTA 540

AAGCTCACAG GATTTCCGAG AAAAGTTACC ATAGGATACT CCAATCTTTT TTCTTCCATT 600

GTATCTGAAA CAGTCAGAAT TTTCCAATGA TTTGACCGGA AATGTGGGCA TAGAAAAAAC 660

GCCAG 665

(2) INFORMATION FOR SEQ ID NO: 83:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1039 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83:

CTAAGTATAA AAAACTTGCC GAAAGTATCT CTGAAGTTAA TTTGAATGTC TTTTTTCAAA 60

ATGCTTTAGA TTTTGTTGAA ATCTTTAATC AAGAGCCTTG TCTGATAAAT TTTTTTGAGT 120

TTATGAATTC TATGTTACAA GGCGATATTC CAAAGTTAAC AATAAACCAA GAATAATAAG 180

AGGGGAACAG TATGAAAGAT ACGATTTCTA ATAAGGATTT GATTTCCATG GGCTATAGAC 240

CATCAACAGC AAATGCTATT ATCCATCAGG TGAGAGAATT ACTTGTATCA CGAGGCTATA 300

CATTTTATAA TCGCAAACGT TTGATGGTTG TTCCAAAAAG TGTTGTGAAA GAGTTGTTGG 360

GAATGGAATT GTGAAATGGC TTATATCGAG TATAAACAGC GTGGGAAGAA AAGGCTTTGG 420

TCGTTTTCTA TACGTGAGAG GAGCAAGAGC CTACTCCATA AAAGCGGATT TAAAACAAAA 480

CGAGAAGCTA AAATAGAAGC GGAGAAAGTT CTTCATAAGT TAAATACTGG GAGTGTCTTA 540

AGCTCTAGTA TGACTTTATC GGAGCTTTAT AATGAATGGC TGGATTTAAA AATTTTACCT 600

AGCAATAGAA GTGTAGTTAC TAAAAAAAAA TATCTTATGA GAAAGAAGGT CATCGAAAGG 660

TTATTTGGAA ATAAGCCTGT ATCACAAATT AAGCCTAGCG AGTATCAAAA AATTATGAAT 720

GAGTATGGAG AGACTGTATC GAGAAATTTC TTAGGAAGAT TGAATTCTAG TATCCAGGCA 780

AGTATACAGA TGGCTATTGC TGATAAGGTG ATAATAGAGG ATTTTACTGC TTATGTTGAG 840

TTGTTCTCTT CTAAGAGTGG ACACAAAGGT TGAGGAAAAG TATCTACATA CTGAGTCAGA 900

TTATCAAAAA GTTTTAGTAT ATTTGAAAAA TAAGTTTGAT TATCAGAAAT CTATTGTACC 960

GTATGTAATT TATTTCCTTT TTAAAACTGG CATGCGTTTC TCCGAATTGA TTGCTCTAAC 1020

TTGGGATGAA GTTGACGAG 1039

(2) INFORMATION FOR SEQ ID NO: 84:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 793 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84:

CTGAGAAGTC AGGAAGGCGA TGTGGAGAGA TTGAGGAATT GGATACTTAA CTCCATAGTA 60

ATCTTCGTAA AACTCGATAG AGCGAACAGC GATATCCAGT GAGAAATCAA GATTTGAAAG 120

TGGATGTGCT TTGGTTGAGT AGACACCCTA CCAGGGTACC ATTTTTAGTT TTAGCGGTCA 180

CCCCTTGCAA ATCACCAGCA ACAAAGGCCA ACAAGTAAGA AGACATGCGA GGTGTTGTCT 240

CAAACTTCCA GATACCTGTT TCCTTACGGT TTTCAACATC GATTTCTGGC ATGTTTGACA 300

AGGCCAATTC ACCTTCTGCT TGGTCAAAGC GAAGAGAGAG GTCAAAAGTT GCTTTGGCTT 360

CAGGCTCATC CACACATGGG AAAGCTTCGC GCGCAAAATG GCTCTCGAAC TGAGTAGACA 420

AGACCTCCTT CTTGACTCCA TCAACTGTAT AATAAGAAGG GTAAATCCCT GTCATGTTGT 480 CTGTAATTTT ACCAGAAAAG GCAAGAACCA ATTCAACTTG ACCAGCCTCA GCCAATTCGA 540

TATGAAGGGC TTCATTGTCA TGGTCAACTG TAAATGGACG AGCTTGACCT GCAACTTCTA 600

CAGAGGTGAT TTCCAAGTCT TTTTGGTGGA GGGAGATGCG GTCACTCTGT GCTTGACCAG 660

TGATGGTCAC TTTCCCAGAA AAAGTCTTGG TCTCACGACT CAAATCTAAA AATAAATCAT 720

AATGTTCAGG AACAAATTGC TTAATAAAAT GTTCAACTGC TTGCATAGTT TTCTCCTATT 780

CTAAGTTTAA GAG 793

(2) INFORMATION FOR SEQ ID NO: 85:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 642 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 85:

CGGATGATTT GCTTTTCATC TATGATAAAG TCTTTGTTGA GCGTCGGAAT CTCTACTGAC 60

TGGAAATTTC CCGTAGATAA TCCAAATGCC CTTTAAAGAA AACCTCATCT GTCAACACCG 120

AAATCATCAC TGCTCCGTTT TCTTCATAAG TCTGGGCCTG TTGCACAATA TCCACATCGA 180

GATTGATATC TCCCCAAAAC TAGGGCTAGC TTTCTTGACT TCAGCGATTA CCTGCAAGCG 240

GTCCTGATGA TTCTTCAAAA ATTCTGCCAA GCGATAGGTC TGGCGCAGAG GCTGGATTTG 300

CTCCAGCTTC ATCTGCTCCA CCTCACGCGC CTTCTGCTCT AAGATTCGTG CTAAAAATTC 360

CTGACTCATT TTTGGTACTC CTGTAACAGT CTGAGTTTTT CAAGGGCCTT GCCTCTAGCA 420

ATCACTTGAC GGGCCAAGGC AACTCCTTCC TTGATGCTAT CAATCTTACC ATTAGCATAG 480

AAACCAAGAC CAGCATTCAA GACTGTCGTT TCCAAGAATG GACTTGCTTC GTTTTTCAGA 540

ACGCTAAGCA AAATTTCTGC ATTTTCCTGA GCATTCCCAC CACGAATATC TTCCATAGCA 600

TAGCCTTCCA TTCCCAAATC CTCTGGAGTA AAGCTTGACA AG 642

(2) INFORMATION FOR SEQ ID NO: 86:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 733 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 86:

CTCTTGCAGG TTATTAAGGA GAAAACGGAG GTAATAGAAG TATGATTTAT ACAGTCACAC 60 TCAATCCATC CATTGACTAT ATCGTTCGTT TGGACCAAGT CAAAGTTGGT AGTGTAAATC 120

GTATGGACAG TGATGATAAG TTTGCTGGTG GGAAAGGAAT CAATGTCAGC CGTGTCTTGA 180

AACGTTTGAA TATATCAAAT ACAGCGACGG GATTTATCGG TGGCTTTACT GGTAAATTTA 240

NCNCAGATAC TTTAGCAGAG GAAGAAATCG AGACNCGTTT TGTCCAGGTG GCAGAAGATA 300

CTCGTATCAA TGTTAAAATC NAAGCAGACC AAGAAACAGA AATCAACGGA ACGGGTCCAA 360

CTGTTGAACC GGTTAAGCTA GAAGAATTGA AAGCTATTTT ATCTAGTCTG ACAGCAGAAG 420

ATACAGTTGT CTTTGCAGGT TCAAGTGCTA AAAATCTAGG CAATGTTATC TATAAGGGAT 480

TTAATCTCCT TGACGCGCCA GACTGGTGCG CAAGTGGTCT GTGACTTTGA AGGACAGACC 540

TTAATTGATA GTTTGGATTA CCACCCTCTT CTTGTAAAAC CAAATAATCA TGAACTTGGA 600

GCGATTTTTG GGGTTAAACT CGAAAGTTTA GATGAAATTG AGAAATACGC TCGTGAGTTA 660

CTGGCTAAGG GTGCTCAAAA TGTTATTATC TCTATGGCTG GTGATGGTGC CCTTCTTGTC 720

ACATCTGAGG GAG 733

(2) INFORMATION FOR SEQ ID NO:87:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 536 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87:

CTAAGGGAAG TAGGAAAAGT ATGTATCCAG ATGATAGTTT GACATTGCAA CACGGACTTG 60

TACCAGATCA ACATGATGCA GGTTTACTTT GATCAAGGGA TTTACAATAA GAAGGCGGTC 120

TTTGAGGTGT ATTTCCGCCA ACAGCCTTTT AAGAACGGCT ATGCGGTTTT TGCAGGTTTG 180

GAAAGAATTG TGAACTATCT TGAAGACTTG CGTTTTTCAG ATAGTGATAT AGCCTATTTG 240

GAGTCGCTTG GTTATCATGG GGCGTTCTTG GATTACCTTC GCAATTTCAA GTTGGAGTTG 300

ACCGTTCGTT CTGCCCAAGA AGGGGATTTG GTTTTTGCTA ATGAACCGAT TGTGCAGGTG 360

GAAGGACCTC TAGCCCAATG TCAGTTGGTC GAAACGGCTC TTTTGAACAT CGTCAACTAC 420

CAGACCTTGG TGGCGACGAA GGCAGCCCCC TATCCGTTTG GTTATCGAAA ATGAACCCTT 480

GATGGAGTTT GGGACACGTC GGGCTCAAGA AATGGATGCG GCCATCTGGG AACACG 536

(2) INFORMATION FOR SEQ ID NO:88:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 568 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88:

CTGCCCCTGT AAGGCTGGAC GATTGCCTTT CTTAGTATCC GCAAAGAGGT AAACTGAGAA 60

TAGAGAGGAT TTCTCCTTCA ATATCTTTGA CAGACAGGTT CATCTTGCCT TCTACGTCTG 120

AAAAAATCCG CATATTGACC AGTTTTCTCA CAGCATAGTC CAAATCTTCC TCTTGGTCCT 180

CTGGTCCAAC ACCAACCAGC AATAAAAGTC CCTGATTGAT TTTTCCCTGA ATCTGGCCTT 240

CTATACTCAC TTGGGCTTTT TTAACCCGTT GGATAATGAT TTTCATAATA GCCTTTCTAG 300

TAAGAGCTAG GACAACTAGC CGTTGGTCCG TTTGACAGAG TAAACTTCTG GCACACTCTT 360

AATTTTATCG ACAACCGTGG TCAGTGTAGA GAGGTTGGCA ATACCGAAGG ACACATGGAT 420

ATTAGCAAAC TTCATATCCT TGGTTGGTTG GGCATTGACC GTTGAAATAT TCTTGGTTGT 480

ATTTGAAAGA ACTTGCAGTA CATCGTTCAA CAGTCCTGTA CGGTTGAGAC CGTAGATATC 540

GATATGGGCC ATATACTCCT TATTTGAG 568

(2) INFORMATION FOR SEQ ID NO: 89:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 800 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 89:

CTTTATATTG TACCAAGTAT CATTTCTAGT GCTGCTATGG GCTTGATTTT TCTTCAAATC 60

TA AATCCAA ACTATGGTGT TGTTAACCAA ATTATTCATC TATTTAATCC ATCGTTTAAA 120

GATTCAGTAC TGTTGACTCC CAGGATTAAA AATAGTAGCT ATGACTGGCG CTTATATCTT 180

CTTTGCAGGA GCATCAACCA TTATGATTTC TTGGGCAAAT TTTTGCTATT CCAGAAGAAG 240

TTCAAGAAGC TGCTATTTTA GACAATATTA CTGGTTGGAG GAAAGAGTGG TATATTACGA 300

TTCCGATGAT TAAGGGGACA AT AAAACTG TTTCAATTAT GGCAGCAACT TCAGGATTTT 360

TGCTCTATAA CGAAGTATTC TTTTTGACAA ATGGTGCTGC AGGAACAAAA AGTATCAGTT 420

TTGTTATTCG AGAATTAGCA GTGGCTAGCT CACGAACTCA GTATGCTCGT GCAAATACAA 480

TTGGAGTTAT ACAAATCTTA GGTGGAATGT TGATTATCGT TTGTATTAAT ATTTTATTCA 540

GAGAAAGAAA AAGACTGAAA GGTGGGAAAT GATTATGAAT ACACATATAA ATGGTATTAG 600

TAAAAAAGGC AAAGTTCTTA TATATGGTTA TATGCTCCTT ACCATTTTAA TTTCTATTTT 660

CCCTATTGCG TGGATTTTTT TATCATCATT AAAAGCAGAT CCTATGAAAA ATCCAGGTAT 720

TAGTTTACCG ACTGACTTTA CTCTTGAAGG TTATATAAAT GTTTTTACAA AACTTCATGT 780

TTTTACTTAC TTTTGGAATA 800

(2) INFORMATION FOR SEQ ID NO: 90:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 686 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:90:

CTCAGTATTA TCCCTACCAA AATGAACGTC AGTTAGTGAC TCAGGTGGTT TGGGAACAAT 60

GGGCTTTGGA ATTCCAGCAG CAATCGGTGC TAAAATTGCT AACCCAGATA AGGAAGTAGT 120

CTTGTTTGTT GGGGATGGTG GTTTCCAAAT GACCAACCAG GAGTTGGCTA TTTTGAATAT 180

TTACAAGGTG CCAATCAAGG TGGTTATGCT GAACAATCAT TCACTTGGAA TGGTTCGCCA 240

GTGGCAGGAA TCCTTCTATG AAGGCAGAAC ATCAGAGTCG GTCTTTGATA CCCTTCCTGA 300

TTTCCAATTG ATGGCGCAGG CTTATGGTAT TAAAAACTAT AAGTTTGACA ATCCTGAGAC 360

CTTGGCTCAA GACCTTGAAG CTACTACTGA GGATGTTCCT ATGCTAATTG AGGTAGATAT 420

TTCTCGTAAG GAACAGGTGT TACCAATGGT ACCGGCTGGT AAGAGTAATC ATGAGATGTT 480

GGGGGTGAAG TTCCATGCGT AGAATGTTAA CAGCAAAACT ACAAAATCGT TCAGGAGTAC 540

TCAATCGCTT TACAGGTGTC CTATCTCGTC GTCAGGTTAA TATTGAAAGC ATCTCTGTTG 600

GAGCAACAGA AGATCCGAAT GTATCGCGTA TCACTATTAT CATTGATGTT GCTTCTCATG 660

ATGAAGTGGA GCAAATCATC AAACAG 686

(2) INFORMATION FOR SEQ ID NO: 91:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 802 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1:

TTTTCCCAGC TATTTTACTG AGTATAAAAG CCTTATTTAA CTTACTCTAT GTACTCGGTT 60

TTCTAGGAGG AATGTTGGGA GTTGGGATTG CTTTGGGGTA CGGAGTGGCC TTATTTGACA 120

AGGTTCGGGT GCCTCAAACA GAAGAATTGG TGAATCAGGT CAAGGACATC TCTTCTATTT 180

CACAGATTAC CTATTCGGAC GGGACGGTGA TTGCTTCCAT AGAGAGTGAT TTGTTGCGCA 240

CTTCTATCTC ATCTGAGCAA ATTTCGGAAA ATCTGAAGAA GGCTATCATT GCGACAGAAG 300

ATGAACACTT TAAAGAACAT AAGGGTGTAC TACCCAAGGC GGTGATTCGT GCGACCTTGG 360

GGAAATTTGT AGGTTTGGGT TCCTCTAGTG GGGGTTCAAC CTTGACCCAG CAACTAATTA 420

AACAGCAGGT GGTTGGGGAT GCGCCGACCT TGGCTCGTAA GGCGGCAGAA ATTGTGGATG 480

CTCTTGCCTT GGAACGCGCC ATGAATAAAG ATGAGATTTT AACGACCTAT CTCAATGTGG 540

CTCCCTTTGG ATCGAAATAA TAAGGGACAG AATATTGCAG GGGCTCGGCA AGCAGCTGAG 600 GGAATTTTCG GTGTAGATGC CAGTCAGTTG ACTGTTCCTC AAGCAGCATT TTTAGCAGGA 660

CTTCCACAGA GTCCCATTAC TTACTCTCCT TATGAAAATA CTGGGGAATT GAAGAATTGA 720

TGAAGACCTA GAAATTGGCT TAAGACGGGC TAAGGCATTC TTTACAGTAT GTATCCTACA 780

GGTGCATTAA GCAAAGACAA TT 802

(2) INFORMATION FOR SEQ ID NO: 92:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 545 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 92:

CTACTATTTT AGCATAAAAA TGCCCAAAGG GGGNGCCGTG TGTTTACTGA TTTTCAGGNT 60

AATGGACCAG GNAAATCAGC ATGAAAATAA AAAGAGAAAC AGATTATTTT AGCCATTTGT 120

CAGATTTATG CTATGCTTAA GGTAGAAAAT GAAAGGGATA ACAAATGTAT TTAGGAGATT 180

TGATGGAGAA AGCCGAGTGT GGTCAATTTT CAATCCTTTC CTTTCTATTA CAAGAGTCTC 240

AGACGACCGT CAAGGCTGTA ATGGAAGAAA CAGGATTTTC AAAAGCAACC CTAACCAAAT 300

ATGTCACCCT GCTCAATGAC AAGGCTTTGG ATAGTGGCTT AGAACTGACT ATTCACTCAG 360

AAGATGAAAA TCTGCGTCTG TCTATAGGTG CAGCTACTAA GGGGAGAGAT ATTCCGGAGC 420

TTGTTTTTTG GATAGTGCTG TTAAATACCA GATTTTGGTT TATCTTCTCT ACCACCAACA 480

GTTTTTAGCC CATCAGCTGG CTCAAGAATT GGTGATTAGC GAGGCTACGC TTGGTCGTCA 540

CTTAG 545

(2) INFORMATION FOR SEQ ID NO: 93:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 576 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:93:

GAGGTCAAGA TTGATTCCCA AGGTTNGAGG AATCTGCGGA ACCAGATTTA GAAGAAATCG 60

AGCGGTTACC ATGCTTGGCC ATGTGAATAC CGCCACCAGC CAAGACAAAG GCTGCAGTTG 120

TGGAAATATT AAAACTGAAA GACTTGTCCC CACCTGTACC ACAGTTGTCC ATAGCATCAT 180

GAATCTCAGT TGGAATATGC TGGGCATGTC CTCTCATGAC TTGGGCAATG GCTGTGCGTT 240 CTTCAGGTGT TTCCCCCTTC ATCTTAAGAG CTAAGAGGAG AGAAGCAATC TGCGCTTCAG 300

TTACACGCCC AGTTACGATA CGCTCAATGA CATCCGTCAT TTCCACACCT GATAAATTTT 360

CAAATTTTGC TAGTTTTTCA ATAATCTCTT TCATCCTAGT TTCCTCACTT TACAACCTCC 420

TCGATAAAAT TCCGAATAGA AGACAAGCCG TCTGGCGTTC CAATGCTCTC TGGATGGTAC 480

TGGAAGCCAT AAATCGGTAG GTTTTTATGT TGAATCCCCA TGATGGCTTG GTCATCAGTC 540

GAACGAGATC AAGCTTATCG ATACCGTNGA CCTCGA 576

(2) INFORMATION FOR SEQ ID NO:94:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 669 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:94:

ATTAAAGGGA GGCGAACATG GCCCAAGATA TAAAAAATGG AGAAGTAGAA GAAGTTCAAG 60

AAGAGGAAGT TGTGGAAACA GCTGAAGAAA CAACTCCTGA AAAGTCTGAG TTGGACTTGG 120

CAAATGAACG TGCAGATGAG TTCGAAAACA AATATTCTTC GCGCTCATGC AGAAATGCAA 180

AATATCCAAC GCCGTGCCAA TGAAGAACGT CAAAACTTGC AACGTTATCG TAGCCAGGAC 240

TTGGCAAAAG CAATCTTACC ATCTCTTGAC AACCTTGAGC GTGCACTTGC AGTTGAAGGT 300

TTGACAGATG ATGTGAAGAA GGGCTTGGGG ATGGTGCAAG AAAGCTTGAT TCACGCTTTG 360

AAAGAAGAAG GAATTGAAGA AATCGCAGCA GATGGCGAAT TTGACCATAA CTACCATATG 420

GCCATCCAAA CTCTCCCAGC AGACGATGAC CACCCAGTAG ATACCATCGC CCAAGTCTTT 480

CAAAAAGGCT ACAAACTCCA TGACCGCATC CTACGCCCAG CAATGGTAGT GGTGTATAAC 540

TAAGATACAA AGCCCGTAAA AAGCTCGCAG TAAAAATAGG AGATTGACGA AGTGTTCGAT 600

GAACACAAGA AAATCTANCT TTTTTACTCA GAGCTTAGGG CGTGTTCGAT TCGGCAATTC 660

TGACGGTAG 669

(2) INFORMATION FOR SEQ ID NO:95:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 615 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:95: CTAGTTCACC ATTTCTATTT AAATTCGGCT CAACTACACC GAAATATCAT ATAAGGTAAA 60

GTTCCCACTA AGAATCTCAG AATGAAATTC TTCACTAACT TCAGCGGTCA AACTTAGCTT 120

ATCCAATTTC AGACCGATAA ACCCATACTT CAGAGATACT TCCTCTTGAA ATTTAGAGTA 180

ACTCTTATTA GACATTTGAT GTATCGTTAT CGGGCTATTA GAAGGAGCCC GATTTAAAAC 240

TTCTTTATTC ATGAAATTTC TCCTTCAAAA AACAAAACAT TCTATATACT TAAATTTTAG 300

GGCAAGACTG CCGTTCCACT GACCACGCTC CACTTGCCAG CAAAGCTGGC AGGTCCAGCC 360

TTACCCTAAA TATAAATTAT TTAATTTTTG CCATTTCAAT CAATTCTGCA AAGGTCCCAA 420

GCTTTCTGGA TTGAATTACC TCATATTGGG CATTCTGTCC AAATGAAGCA TTATTAATCA 480

CTTCAACCTC ATAAAGGCCT GGAGCAGAGA AAACAGCTCC AAATTTGGAT TTATCGAAAT 540

GCATACCTAG GTCACTCCAA CAATCATTAA GGGTGGAGAC TTTTATCCAG CCTCGTTCTT 600

TCTTAGTAGA AATAG 615

(2) INFORMATION FOR SEQ ID NO: 96:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 773 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96:

CTACTGTAGT TGGAACTGTT GAAAAACAAG GAAAACAAAA GAAAGTTGTT ACTTACAAGT 60

ACAAACCTAA AAAAGGTAGC CACCGTAAAC AAGGTCACCG TCAACCATAT ACAAAAGTTG 120

TCATCAACGC AATTAACGCT TAATTTTAAG GAGAACACAT GATACAAGCA GTCTTTGAGA 180

GAGCCGAAGA TGGCGAGCTG AGGAGTGCGG AAATTACTGG ACACGCCGAG AGTGGCGAAT 240

ACGGCTTAGA TGTCGTGTGT GCATCGGTTT CTACGCTTGC CATTAACTTT ATCAATTCTA 300

TTGAGAAATT TGCAGGCTAT GAACCAATCC TAGAATTAAA CGAAGATGAA GGTGGCTATC 60

TGATGGTTGA AATACCAAAA GATCTTCCTT CACACCAGAG AGAAATGACC CAGTTATTCT 420

TTGAATCATT TTTCTTAGGT ATGGCAAACT TATCGGAGAA CTCTTCTGAG TTCGTCCAAA 480

CCAGAGTTAT CACAGAAAAC TAACACGGAG GAAAACATTA TGTTAAAAAT GACTCTTAAC 540

AACTTGCAAC TTTTCGCCCA CAAAAAAGGT GGAGGTTCTA CATCAAACGG ACGTGATTCA 600

CAAGCGAAAC GTCTTGGAGC TAAAGCAGCT GACGGACAAA CTGTAACAGG TGGATCAATC 660

CTTTACCGTC AACGTGGTAC ACACATCTAT CCAGGTGTAA ACGTTGGTCG TGGTGGAGAC 720

GATACCTTGT TCGCTAAAGT TGAAGGCGTA GTACGCTTTG AACGTAAAGG ACG 773

(2) INFORMATION FOR SEQ ID NO: 97:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 713 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97:

CTGGATAATT GGAGCAATTC CTGATGCCAG TTTGAGGTTA CTGATAGGAT TGTGGGCGAT 60

AGCCACTTGA GAAGATGCCA AGAGTTCAAT TTCTCTCTCG TTTAATTCGA CCCCGTGAGC 120

AAATACGGAC GGATGATCTA AATAACCCAG TTCTTCAAGA AAAGCAAGGG GGCGTTTGCC 180

GTACCGTTTG AGGATAATTC CTGACTCCTC CTTGGTCTCC GCCACATGGA CATGGAGCGG 240

AATATTTAGC TCTTTTGCCA TTTCCAAACT CGCTTCCAGC AAGTCTCTAC TGCAGCTATA 300

CGGAGAATGA GGTGCTACCA TAACCCTTGA AATTTGGGAT TTTTATATTT TAAGATTTCG 360

TCTATGATGG ATCGAGTTCT GCTTATAGTC TCAGCAGTTG TTTCTGTCTC TGAAGAAAAG 420

AGAGTCGGAG AAAAATAACA ACGCATCTTG GAAGTTTTCA CCACCTGATA AATTTGCTGG 480

ATATCCACAC CATTGGGATT ATACATATCG TTAAAGGTTG TTGTTCCTGA CTGGAGCATC 540

TCTGTTAGGG CTTCTTTGAC CGCATTGGTA GTCATGTCGG GAGTAAACTC AGATTCTGCT 600

GGCCAGATAT AGTCATTGAG CCATTTCATG GAGATTGCTG TCATCTCGGA TCCCTCTCAG 660

ACCTGTCATT GCAGAATGGG TGTGACAATT GACCAAACCA GGCATAAGCC AAG 713

(2) INFORMATION FOR SEQ ID NO: 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 778 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 98:

CTAGAAAATC TGCTTTTTTC TCGAAAAGTT TAATACTTGG TACAATATTA CGCTTGCTTT 60

GCTCGGCTGC TCCAAGGGCA ATTTTTTCTA GTTTTTCAAC TTTTTTACCC AATTTCTTGC 120

CATCCCACTT GGCAACTGAC CAGTCTGCAG GAAAGGCCCA GATTTGGCTA GCACCCAGTT 180

CGGTTACTTT TTGAGCGATG AACTCCAGCT TGTCTCCCTT GGGAAATCCA GATGCGATGG 2 0

TCACTTGGAC TGGTAGTTCC ACATTGTCAT TTAATTCTTG GACCAACTCA AACTGACGAT 300

TTTCCATATC CAGCACGCGC GCCAAGCGCT TGATGCCATC ATCAAAGACT AAGGTAACCT 360

CATCCTCTTC TTTCAAGCGC ATAACCTGAA ACATATGCTT ACTGGTTTCC TTGTCCTCGA 420

TAGTGACAGG AGAGATAGCA CTGCCTTTTA CAAAATACTG CTGCATGCTA GCCTCCAATC 480

ACACCAGAGA TATCCTTGGT TTTCTTAAAG ACACAGGTAT TCCATTCCCC TTGAACCATG 540

TGAGTTTCGA GGAAAAATCC AGCTGATTCA GCCGACTCGC GCACCATGTC CCACTTATGC 600

CTTGAATAAT GCCACTCATG ATCAGGTAGC CTTCGTCCTT AACCAAACGA TAGGCATCGT 660

CTATTAGATG AATGAGGATA TCCGCCAAGA TATTAGCCAC AATCACATCT GCCTCAATTT 720

CCACACCCTT AAGCAAATCT CCAGCCGCTA CATGGATATT TTCCATGCCA GGGTTGAG 778 (2) INFORMATION FOR SEQ ID NO:99:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1062 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99:

CTTCCCAGAT TTTTTCGTTG ACTTGCTGTT CAATCGCACG CAATTCTTCA GCAGTTACAG 60

CTTGGAAGTG GGTAAAGTCA AAGCGAAGGA ATTCAACTTC GTTAAGAGAT CCTGCCTGTG 120

TTGCGTGGTT TCCAAGGATA TTGTGAAGGG CAGCGTGAAG CAAATGAGTC GCAGTGTGGT 180

TTTTCATGAC ACGGTGACGG CGATTGCTAT CAATTGCCAA GGTATATTCT TGGTTCAAGG 240

CAAGCGGTGC AAGGACTTCA ACTGTATGAA GGGCTTGACC ATTTGGGGCT TTCTGAACAT 300

TGGTCACAGT AGCCACAACC TTACCTGACT CATCCAAGAT TTGTCCGTAG TCAGCTACCT 360

GTCCACCCAT TTCAGCATAA AATGACGTTT CCCGCAAAGA TAAGAGAGGC AGTTCCTTCT 420

GAAACAGCTT CTACTTCTGC ATTGTCCGCC ACGAATAGCT ACCAATTTAG AAGACAATTG 480

GCTAGCATTG TAGTTGAAGG CACTTTCTAC AGTGATGTTT TGAAGAGTTT CCATTTTGCA 540

TACCCATTGA GCCACCCTTG ACAGCTGACG CACGCGCGCG TTCTTGTTGT TCTTTCATGG 600

CTGCTTCAAA ACCTTCACGG TCTACAGTCA TACCAGCTTC TTCAGCGATT TCTTCAGTCA 660

ATTCAACTGG GAACCCATAA GTATCATAGA GTTTGAAGAC ATCTGAACCA GCGATAACAG 720

ATTGACCTTT TTCTTTCAAG TCTGCTACAA TGCCTTGGGC AAAGTGTTGA CCTTGAGTGA 780

AGGGTACGGG CAAATGATTC TTCTTCGCCT CTTAACGATT TTCTCAATAA AGTCACGTTT 840

CTCAAGCACT TCTGGGTAGT AGCTTTCCAT GATTTTTCCA ACAGTTGGAA CGAGTTTTGT 900

AAAGGAAAGG CTCGTTGATA CCCAATTTTT GACCCATGCA TAGAAGCACG ACGGAGAAGA 960

CGACGAAAGG ACATAACCAC GACCCTCCAT TTCCTGGAAG GGCACCATCC ACCGATGGCA 1020

AATGAAAGTG AACGGATGTT GGTCCGCGAA TGAACCTTGA AT 1062

(2) INFORMATION FOR SEQ ID NO: 100:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 865 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100: CTCAAAGGTC GCACCTGCAA TACGACCCGC TACAGGACCT ACACTTGCTC CATGCTTGGG 60

ACTATTGCCT ACATAACTAC CAAAGTCATC AAATCCCAAG ATAACATTGG CAAAATTTCC 120

AGCCTTGTCA GGTGCGACAT AGCGCAAGAT AGTCGCACCA TAAGTCATAA CCTCAAGTTG 180

GTAGCCACCG TCTGTCTCAA ATCGATAGGC CAAGACATCC TCACCCTCAA CATTTCCAAA 240

TACACGCTCT GTGTATGCTT TCATTCTGTT CTCCTTTTAC TATTTCTCTC AAGCAAACAA 300

ACCATAGAAA GCGTACTGAC AATCTATGGT TTATCTGATA ATTTACAAAT CCTCTTGTCA 360

AGAATTCATA AACACTGTCT TACTTTTGAT ATTCGTGAAT TATGACACCT TGTACTACAC 420

GGTTTACTGT ACCTGTAGGA GACGGTGTAT CTGGTTTATT TTCTACCTTG AGTGAAGTCA 480

ATAGGGCAAA GAGTTGGGCA TAAACGATGT AAGGGAAGAC ACGGTAAATA TCATTCAAGA 540

CACCGCCACA ACCAAGGGCC ACTTCTTTGA CATTTTCAAG ACCAAAAGCT TGATCACTCA 600

AAAGCACAAC ACGACGAGCA ATCTGGTCAC CAGCAACTTC ACGAACCAAG TCCAAGTCGT 660

ACTTACGAGT GTAGTCCGTC CTTGTACCAA AGAACAAAAC AACTGTATTG TCGTTGATAA 720

GATATTTGGA CCGTGACGGA ACCAACTGGG CTTTCATACA TGGTCGCAAC TTGAACAACA 780

GTTAATCCCA AATCTTGAGC TGAGCCTCAT GAGCAGTCCA AAGAAGACCA GCGCCTAGAA 840

GAGACCGGTT AAGTCTTAAT CACAG 865

(2) INFORMATION FOR SEQ ID NO: 101:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 946 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 101:

TTTTGCTCCA GTTGATAAGA AAGGCTTGGT CGATGTTGAG GCGTTAGCAG GTTTGATACG 60

GCCTGATACA ATCCTCGTTT CCCATCATGG CTGTGAACAA TGAAATCGGC TCTATCCAAC 120

CNATTGAGGC TATTTCAGAA TTCTTGGCAG ACAAGCCGAC TATTTCCTTC CACGTTGATG 180

CGGTTCAGGC GCTTGCCAAA ATTCCGACTG AAAAGTATCT GACAGAACGG GTGGATTGCG 240

CGACCTTCTC GAGTCATAAA TTTCATGGTG TCCGTGGTGT TGGCTTTGTC TATATCAAAT 300

CTGGCAAGAA GATTACACCT CTTCTTACAG GTGGTGGCCA GGAGCGAGAT TATCGTTCGA 360

CAACTGAAAA TGTGGCAGGG ATTGCAGCGA CAGCCAAGGC TCTCCGTTTA TCTATGGAAA 420

AGCTAGATAT CTTTAGGAGC AAGACTGGGC AGATGAAGGC AGTGATTCAC CAAGCTCTTC 480

TGAACTATCC GGATATTTTT GTCTTTTCAG ATGAGGAAGA CTTTGCACCT CATATTCTGA 540

CTTTTGGAAT CAAAGGTGTT CGAGGTGAAG TCATCGTTCA CGCCTTTGAA GACTATGATA 600

TTTTCATCTC AACAACCTCA GCTTGTTCAT CTAAGGCAGG AAAACCAGCC GGTACCTTGA 660

TTGCCATGGG AGTGGACAAA GATAAGGCCA AGTCAGCTGT GCGTCTTAGC CTAGACTTGG 720

AAAATGATAT GAGTCAGGTC GAGCAGTTTT TGACCAAGTT AAAATTGATT TACAATCAAA 780

CTAGAAAAGT AAGATAGGAG CATTCATGCA GTATTCAGAA ATTATGATTC GCTACGGAGA 840

GTTGTCAACC AAGGGTTAAA AACCGTATGC GTTTCATCAA TAAACTTCGT AATAATATTT 900

CGGACGTTTT GTCTATCTAT ACCCAAGTTA AGGTAACAGC AGATCG 946 (2) INFORMATION FOR SEQ ID NO:102:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 552 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 102:

CTTGCTCGTA ACAGGTGCTA TCCTTGGTGT CAATGTTCAC ATCTTCTCAC CAAAAGAACT 60

CTTCCCAGAA AAAGAAATCG TTGAATTGGC AGAAGGATTT GCTAAAGAAA GTGGCGCACA 120

TGTTCTCATC ACTGAAGATG CTGATGAAGC AGTTAAAGAT GCAGACGTTC TTTACACAGA 180

CGTTTGGGTA TCAATGGGTG AAGAAGACAA ATTCGCAGAA CGTGTAGCTC TTCTTAAACC 240

TTACCAAGTC AATATGGACT TAGTTAAAAA AGCAGGCAAT GAAAACTTGA TCTTCCTACA 300

CTGCTTGCCA GCATTCCACG ATACTCACAC TGTTTATGGT AAAGACGTTG CTGAAAAATT 360

TGGTGTAGAA GAAATGGAAG TAACAGACGA AGTCTTCCGC AGCAAG ACG CTCGCCACTT 420

CGATCAAGCA GAAAACCGTA TGCACACTAT CAAAGCTGTT ATGGCTGCTA CACTTGGTAA 480

CCTTTATATT CCTAAAGTAT AATTTTAGAT AATAAACCGT CTACCAACAG CTATGAGGGC 540

TGCGACTAAT AG 552

(2) INFORMATION FOR SEQ ID NO:103:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 512 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103:

CTAAAAAAAG TCAAGTAGAA AACGAATATT CTACTTAACT TGCACGAAAT TATTTTTCAC 60

GAATGACTTC GACCTTATAT CCATCAGGGT CTTTGACAAA GTAATAGTTT GGTGCAGTTC 120

CTGGTAGACC ATTTGGCTCA GTCACTTCAT AGCCTTTTGT ACTGTGCTCT TGATGAAGTG 180

CCTCAAGATC AGGTGTACTG AGGGCGATAT GGGCAAACCC ATCACCAACC ACATACGGAC 240

CGTGATCGTA GTTATAAGTC AACTCCAACT CATAGTCATC ACCCTCAAGA CCTAGATAGA 300

CAATCGTGAA GGCATGGTCT GGAAAATCTC TGCGACGCAA TTCTTTAAAA CCAAAAGCAT 360

CTTGATAAAA TGCAATTGAT TTTTCAAGAT TTTCTACTCG TAAGCAAGTG TGTAGCATTT 420

TTGAAGCCAT ATCTTTCTCC TTTATTTTTA AAAAGACTGG ACAATCCTGT TCCAGTCTCA 480 TCAGTTGTTA TTTACCAAGT TTTGCTTTAG CT 512

(2) INFORMATION FOR SEQ ID NO:104:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 551 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104:

CTGGACCACA CTATTTTCTG TGTTGGCTAT CGTGTCATGC AAAAGGATCT AGAAGGGACG 60

CTGGATGCTG AAAAACTCAA GGCTGCTGGT GTTCCGTTCG GCCCGCTTTT TGGTAAAATC 120

AAAAACGGCC AGGATCTTGT TTTGGAAGAC GGAACTGAAA TCAAGGCAGC AGACTATATC 180

TCAGCGCCAC GTCCAGGTAA GATTATCACT ATTTTAGGAG ACACTCGAAA AACGGATGCC 240

AGTGTGCGTC TGGCTGTCAA TGCAGATGTC CTAGTTCATG AGTCCACTTA TGGCAAGGGT 300

GATGAAAAAA TTGCTCGTAA CCATGGTCAC TCAACTAATA TGCAAGCTGC ACAAGTAGCG 360

GTAGAAGCAG GTGCCAAACG CCTCCTACTC AACCATATCA GTGCCCGTTT CCTCTCAAAA 420

GATATAAGCA AACTCAAGAA GGACGCTGCC ACAATTTTTG AAAATGTCCA TGTGGTCAAA 480

GACTTGGAAA AAATGGAAAT CTACCAGTCA CAGAAAGGAT AAGTATGCCT ACTATTCTCC 540

ATTAACCGGA A 551

(2) INFORMATION FOR SEQ ID NO: 105:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 529 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:105:

CCGTCATTAT ACCTTTGTCT ATGAAAATGA AGACCTAGTC TATGAGGAGG AAGTCTTATG 60

ATACAGCCAG CAAGTTTAGA AGAATTAGCA TCTTTAGTGG AAAAAGCGGG CAAGAAGGTC 120

TTCCTTTTTG TGGCAGACTG GTGTGGCGAT TGTCGTTATA TTTATCCTGC CTTACCAGAG 180

ATTGAGGAGA CCAATCCAGA GTTCACCTTT ATTCGAATGG ACCGAGATCA GTATATGGAT 240

TTGGCCAAAC TCTGGGATGT TTACGGAATT CCTAGCCTTG TTGTTCTAGA AAAGGACAAG 300

GAAATTGGTC GTTTTGTCAA TCGCGACCGT AAAAGTAAGG AGCAAATTAA CGATTTTTTA 360

GCAGGATTGA AATAGGAGAA AAAGGAAACA ATGATTTTTA CGTATAACAA AGAACATGTC 420 GGTGATGTCC TTATGGTCAT CGTGAAAAAT AGCGGAGATG CCAAACTGAA TGTGGAACGC 480 AAAGGCAAGG TAGCCCGTGT TTTCCTCAAA GAAAATGGGG AAACAGTAG 529

(2) INFORMATION FOR SEQ ID NO:106:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 663 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106:

CTAGGATAGA CCGCTTTTTA GCATTTATCT AAGCATTCCA GAGTACATGT ATCTTGCATG 60

TGCTCTTTCT TTTGGGGTTG AAACGATAGG AGAAGGAAAT GTTAGAATTG CTTAAATCAA 120

TCGATGCTTT TGCTTGGGGA CCGCCCCTCT TGATTTATTG GTCGGAACAG GGATTTACCT 180

AACCATGCGG CTAGGACTCT TGCAGGTTTT GCGTCTGCCC AAGGCCTTTC AGCTTATTTT 240

TATCCAGGAT AAGGGACATG GTGATGTATC CAGTTTTACA GCTTCTTGTG TAACAGGCCC 300

TTGGGCATTC AAACTGGTTG GGAAACAGGG AAATATCCAT TAGGGAGTTG GCGACGGCTA 360

TCAAGGTTGG TGGACCAGGA GCTCTATTTT GGATGTGGAT GGCGGCTTTC TTTGGAATGG 420

CTACCAAGTA TGCGGAAGGA CTCTTGGCCA TCAAATACCG CACCAAGGAC GACCATGGTG 480

C GTAGCGGG AGGTCCCATG CATTATATCC TTCTAGGGAT GGGAGAAAAG TGGCGACCAC 540

TTGCTGTTTT GTTTGCAGTA GCAGGAGTAT TGGTTGCTCT CTTGGGAATC GGAACCTTCA 600

CCCAAGTCAA CTCGATTACA GAATCTATCC AAAATACAAC GACGATTTCG CCAGCCATCA 660

CAG 663

(2) INFORMATION FOR SEQ ID NO: 107:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 727 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 107:

CCTTGACCAC CAATTCTTCA CCCGATATGA TGCGCCCTGC TCGCTGAGCA AGCCCCAAGA 60

GATTACTTAT CTTTTGCTTA TTCAAGTCCC AACTCTCTTC TTTTCACTTT GTGATCCACA 120

TAAGCGATCA ACTCGTCATA AAAGCTTTCT TCCACTTCCA TGCTAAAGCT GCGGTTAAAG 180

ACCTTCTTCT TTTTCGCCTC TAGGGCTTCT GCATTGTCTA GTTTGATATA AGCGCCGCGG 240 CCATTGGCCT TGCCCGTAGG ATCAATAAAG ACTTGTCCTT CCTTGTTCTT GACAATGCGG 300

AGCAAATCAC GCTTATCAAT CACTTCGTTA GACACAACAG ACTTGCGCAA AGGGATTTTT 360

CTTGTTTTCA TCTTTCCCTC CTCTAGCAGC TTTTATTCTT CTACAGTATC GTTTTCTACT 420

TCCAACTCTA CTGAAGCAGC GTCTTCCATG GCTTCAAATT CGCTAGCAGA CTTGATATCG 480

ATACGGTAAC CAGTCAAGTG AGCCGCCAAG CGCACGTTTT GTCCACGACG ACCAATGGCA 5 0

AGAGAAAGCT TGTTATCTGG AACAACCACC AAGGCACGTT TGCTGTCGTT TTCATCAAAG 600

ATAACTTGGT CAACCTCAGC AGGAGCGATG GCATTGTAGA TAAATTCAGC TGGATCTGCT 660

ACCCACTCGA TAACATCGAT ATTTTCTTCG ATTGGTACCA TGCGGTCATT TTTAGCATCG 720

TAACGAG 727

(2) INFORMATION FOR SEQ ID NO: 108:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 563 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 108:

CTAATGTAAA TCTATGGGAT AAACGTTAGC TTCTTTTAAT AGATTATTAA GCAATTTTTT 60

AAAACAACTC ATCAAACAAA CTCAACTGGT TATCTCTGGC ATATTTCCAA GAATACCCAT 120

CTCATCCATC TTTTCAACCA AGGTTGATGA GAGTCCACCA CGCTTGCGTA GTTCTGTTTT 180

AGAGAGGAAT TCTCCCTCTT CACGCGCCCG CACCAGTTGC TTGGCAACGT TCTCCCCCAG 240

ACCATCCATT GCTACAAATG GTGGGATAAG GGTATCCCCG TCGATGAGGA ACTCTGTCGT 300

CTGACTACAG TAGAGATCTA ATTTACCAAA CTTGAAACCT CGTTCCCACA TCTCATTGAC 360

AATCTCAAGA GTTGTATAGA GATCGATTTC CACATTAGAG GCTTCATTGT TCTTCCGTTT 420

TTCAGAGATT TCTTCCATTC TGCGCTTGAT GACCTCCAAG CCCGCACCCA TGGTCTTGAT 480

ATCAAAAGCC TTAGCACGAA TGGAGAAGTA AGCACAGTAG TAATAAATAG GATGGTGAAC 540

CTTGAAGTAA GCTACACGCA AGG 563

(2) INFORMATION FOR SEQ ID NO: 109:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 647 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:109:

CTAACTTCAA AAGCTTTTAG AATATCTTCT TGACTAATCA TATGATTACC GCCCAAGGTT 60

AAGTTTTCCA AAATAGAGCC ATTAAAGATA TAGGCTTGTT GGGGTAGGTA ATTAATATGA 120

CGGCGCAAGA CTTTTTTTAT CAATGTTTTT AATATCCTGA TGATTGATGG AAATATGCCC 180

TTTGTAGGGT TCAAAGAAAT TGACAATCAT TTTGGCTAAA GTTGTTTTAC CAGAACCACT 240

AACTCCAACT AGGCTAACCT TATCTCCTTG TTTAATCGTG AGATTAATAT CTGTTAAGGT 300

ATCTCGTCCA AAACCATACT TATAAGAAAG GTCATCAAAT TCAATATCGC CCATCAAAAA 360

ATGTGAATGA ACAGGGTTTT CTTGAACTTG AAATTCAGAT TCGACTAGAT AGACTTCGTT 420

CAAACGGTTA TTAGCGACCT TCGCAGATTG GAGTTTGGTT TGGAGGTTGA TAATATTTTC 480

CATAGGAGTT GTAAAGTAAG AAAGAAGTGT GTTAAAGGTA ATCAGCTGAC CGATAGAAAT 540

TTTACTCGAC ATGACTAATT GAGCGCCAAA CCATAGGATA AGGATATTCA GAACTAATTT 600

TGTTTCCCCT GCTTTAAACT CGTTTGTAAA ATAGAATATT TACTGAG 647

(2) INFORMATION FOR SEQ ID NO: 110:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 610 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 110:

CTATCCTNGA ACCAATGATG CTTGTAACAA TCACTGTTCC AGAAGAAAAC CTTGGTGATG 60

TTATGGGTCA CGTAACTGCT COTCGTGGAC GTGTAGATGG TATGGAAGCA CACGGTAACA 120

GCCAAATCGT TCGTGCTTAC GTTCCACTTG CTGAAATGTT CGGTTACGCA ACAGTTCTTC 180

GTTCTGCATC TCAAGGACGT GGTACATTCA TGATGGTATT TGACCACTAC GAAGATGTAC 240

CTAAGTCAGT ACAAGAAGAA ATTATTAAGA AAAATAAAGG TGAAGACTAA TCCGTCCTCA 300

CTCTAGAAGG AAGTCACTTA GTGGCTTCCT TTTGTCTTTA GAAAATACCT CTAAATATGG 360

TAAAATAGTA GAAGAATAAT GTGAGGAAAA TGAATGTCAA ATAGTTTTGA AATTTTGATG 420

AATCAATTGG GGATGCCTGC TGAAATGAGA CAGGCTCCTG CTTTAGCACA GGCTAATATT 480

GAGCGAGTTG TGGTTCATAA AATTAGTAAG GTATGGGAGT TTCATTTCCG TATTTTCTAA 540

TATTTACCTA TTGAAATCCT TTTTACAATT AAAGAAAGTT TGAGCGAAGA ATTTCCTNAG 600

AANGCCATCA 610

(2) INFORMATION FOR SEQ ID NO: 111:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 984 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 111:

TATAAGCATA GTACCAGTTG CCATTGACCT GGAACCAACT GTCTTCATAT CTCCATTACT 60

GCATTTAGGT AGTACCAAGT TGAACCATCT TGATACCAAC CAGTTGCCAT TGCTCCTGAT 120

GAACGGAGAT AGTACCATTT GTTCCCAAGG TTTTGCCAAC CTGTTTTCAT ATCGCCATTT 180

GGCTGGTCTA AATAATACCA AGTGGTACCT TCCTGATACC AACCAGTTGC CATTGCTCCT 240

GATGAACGGA GATAGTACCA TTTGTTCCCA AGGTTTTGCC AACCTGTTTT CATATCGCCA 300

TTTGGCTGGT CTAAATAATA CCAAGTGGTA CCTTCCTGAT ACCAGCCAGT GGCCATTGCT 360

CCTGAGGAAC GGAGGTAGTA CCACTTATTA CCTAGATATT GCCAACCTGT TTGCATAATA 420

CCAGTTGTTG GATCTAAATA GTACCAAGTC AAATCATCGT TTATCCACCC CGCACGTCTT 480

TCACCACCAA GGTAGTTTTC TCCAT AATT TCCGTCTTAG CTAGATAATA CCAGTAGACT 540

GATCATAAAG CCAACCTGTC TCTAAAGAAT GATTTTGATT AAAGTAATAG TTCGTATAAT 600

AACGNTTCTC TTCTTTATCT TCTGAATCTT CACGTTTTTC CCCGTACTTT CTTCCAACAC 660

TGTCTTTAGT TTTAATCTCT AATGTTTTCC AACCAACAAA CTCTTGTAGC ACTCCATTTT 720

TATCGAAGTA GTACCACTCT GAATTTGGAA AACCTTCTAA TCTCATACCA TTTGGGTAAG 780

GACCAATTGT ACTACCTTTA GATGGAAACG GGATATATTG CCAGCCGACA ACCATCTCTC 840

CAGATAGAGA ATCAAAATAA TAGTACTTAC CATCAATCAC TCGCCAGTAG GTTTCTTTGA 900

GGTCCCCCTT TTTGTAATAG GTTCTACCGT TTTCTTGGAC AAACTGCCAT CCTTCAGAGT 960

TATCTGCAAA TACTGTATTC GTAG 984

(2) INFORMATION FOR SEQ ID NO:112:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 842 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:112:

CCTCGTTATG CAGATGAACG TTATTTCTTG TCAAAGAGTC ACAAGAATTT TGTTGATCGT 60

AATCTTTTTA TTACCATTCG TGACAAGGAA ACCACCTGTA TCAAGCCTTA TCAGCAGGAT 120

TTGGATTTGC CACATGGTCT GGCCTTGGAT GTTTTGCCTT TGGATTATTA TCCGAAAAAT 180

CCAGCTGAGC GGAAAAAACN GGTTCGTTGA GCCTTGATTT ATTCACTCTT TTGTGCGCAA 240

ACTATTCCAG AAAAGCATGG TGCTCTCATG AAATGGGGAA GTCGCATTTT ACTGGGTTTG 300 ACTCCAAAAT CTCTCCGTTA TCGCATCTGG AAAAAAGCTG AGAAAGAAAT GACTAAGTAT 360

GATTTGGCTG ATTGTGATGG CATTACAGAA TTATGCTCAG GTCCTGGCTA CATGAGAAAC 420

AAGTACCCAA TCACATCTTT TGAAGACAAT CTTTTCTTGC CATTTGAAGG AACAGAGATG 480

CCTATTCCAA TCGGCTATGA TGTCTATCTC AGAACTGCTT TTGGGGATTA TATGACGCCT 540

CCACCAGCAG ACAAGCAGGT ACCGCATCAG GATGCTGTCA TCGCTGATAT GGATAAGTCT 600

TATACAGAAT ACAAGGGAGA ATATGGTGGC TAAGAAAAAA ATCTTATTTT TTATGTGGTC 660

TTTTTCTCTT GGAGGTGGTG CAGAGAAGAT TCTATCAACC ATTGTTTCAA ATCTGGATCC 720

AGAAAAGTAT GATATTGATA TTNTTGAAAT GGAGCACTTT GACAAGGGAT ATGAATCTGT 780

TCCAAAGCAT GTACGCATTT TAAAATCCCT TCAAGATTAT CGCCAAACCA GATGGATACG 8 0

AG 842

(2) INFORMATION FOR SEQ ID NO: 113:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 749 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113:

CTGGCAAATA CAAGGTGACG ATCATTGGTA AATCAGCCCA CGGTGCTATG CCTGCTTCAG 60

GTGTCAATGG TGCGACTTAC CTAGCCCTCT TCCTTAGCCA GTTTGACTTT GCTGGTCCAG 120

CCAAAGAATA CCTTGACATC ACTGGTAAAA TTCTCTTGAA CGACCATGAG GGTGAAAGTC 180

TCAAGATTGC TCATGTGGAT GAAAAGATGG GTGCCCTTTC TATGAATGCA GGCGTCTTCC 240

GCTTCGATGA AACAAGTGCT GATAATACCA TTGCCCTCAA CATCCGCTAT CCAAAAGGAA 300

CAAGTCCAGA ACAAATCAAG TCAATCCTTG AAAACTTGCC AGTTGTTTCT GTTAGCCTGT 360

CTGAACACGG TCACACGCCT CACTATGTTG CCAATGGAAG AATCCACTTG GTTGCAAACC 420

TGGTTGAAAT GTCTATGAAA AACAGACAGG CCTTAAAGGT CATGAACAAG TCATCGGTGG 480

TGGAACCTTT GGTCGCTTGT TAGAGCGCGG AGTTGCCTAT GGTGCTATGT TCCCAGACTC 540

AATTGATACC ATGCACCAAG CCAATGAATT TATTGCCTTG GATGATCTCT TCCGAGCAGC 600

AGCAATTTAT GCCGAAGCTA TTTACGAATT GATCAAATAA AACGATAGAA GTCTGAGATC 660

TTATGCTTGG ACTTCTTTTT GGAGGGAAAG TAGATGTCTC AAATCGAAAG AATCAAACAG 720

GCTATCATGG CGGATTCACA GAATGCCAG 749

(2) INFORMATION FOR SEQ ID NO: 114:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 503 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114:

CTGGATGAAT TGCAGAAGCG CAACCTACTG GGATTTGTCT TCCAAGATTT TCAACTATTT 60

CCTCATCTAT CAGTTCTGGA AAATTTGACT TTATCGCCTG TGAAGACCAT GGGAATGAAG 120

CAGGAAGAGG CTGAGAAGAA GGCGAGTGGA CTCTTGGAAC AGTTAGGACT AGGAGGACAC 180

GCAGAGTCCT ATCCTTTCTC ACTATCTGGT GGGCAAAAGC AGCGGGTGGC TTTGGCGCGT 240

GCTATGATGA TTGACCCAGA AATCATTGGC TACGATGAAC CAACTTCTGC CCTGGATCCA 300

GAATTACGTT TGGAAGTGGA GAAGCTAATC TTGCAAAATA GGGAACTTGG GATGACCCAC 360

ATTGTGGTTA CCCATGATTT GCAGTTTGGC TGAAAATATC GCACATGTTA TTATTGAAAG 420

TAGAACCTCA AATAGGAAGA AAAATGGATT GAAAAAATGG ATGCTTGTAT TAGTCAGTCT 480

GAAGACTGCC TTTGTTCTTA GTA 503

(2) INFORMATION FOR SEQ ID NO:115:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 615 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 115:

CTGGAGGGCA TTCAGTATTA CTTGAATAGA GGAAAACATC ATCTCCCTTA TGTTCTCAAT 60

ATTGGATTTC CTGGTCAGAA AAATGACCTC TTACTCCTTC GGCTAGATTT AGCTGGAATT 120

TCAATCTCTA CTGGCTCAGC CTGTACTGCA GGCGTTGTCC AATCCAGCCA TGTTCTTAAA 180

GCCATGTATG GCGCAAATTC AGAACGCTTG AAGGAATCCC TTCGCATCAG TTTGTCGCCA 240

CAAAATACCG TTGAAGACCT ACAAACCCTC GCAAAAACCT TAAAAGAAAT TATCGGAGGT 300

TAGCCATATG GCATTTGAAA AAATCATTCA GTTAAAAAAT TGTCGTTACG ATTACACTCT 360

TAGCCCTTCT GTTAAAAAAT TCACCCTCAA AGATAACACC TTTTTTGAAA CTAAGGTTGG 420

TAACTATGAA CTGACTCGCC TTTTGGAAAA AGTGCCAAAC AGCGGTGAAG GCTTCCAACT 480

CAAAATCATC ATTAACAAGG AACTTACAGG GGCTAAAATC AA ATCACTG ACAAGTTTGG 540

CCTTCGTCTA GTTGATATTT TCAAATCAGA AGACCACCAT ATTCATCAGG AAAAATTCTA 600

CTTCCTCATG GATAG 615

(2) INFORMATION FOR SEQ ID NO:116:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 954 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:116:

CTGCAATGGT TAGCGAGGAT GGTGAAATAG AGGAGCCTTA ACTATTTTGA GGAATCCAAG 60

CTGACAGGAC TGGTATGTCT GCTCTTTGGC TCTGAAGGCA GACTATACCA GCTGGAAGTT 120

TGACAGATGT GGCACGTGAG AATTATTGGA GGCNTTGACN TANTCAGAGG ATTCTCTCTT 180

GATATTGGGT TTGGCAGAGT TGGATAGTGA GTTGGAAAAT TACCAAGCGG TTATTCAAGC 240

CTATGCCCAG TTAGATAATC GCTCGATTTA TGAGCAAACG GGCATTTCCA CCTATCAACG 300

AATTGGCTTT GCCTATGCTC AGTTAGGGAA ATTTGAAACG GCTACTGAGT TTTTAGAAAA 360

AGCCCTGGAG TTAGAATACG ATGACTTAAC AGCTTTTGAG TTGGCCAGTC TTTATTTTGA 420

TCAAGAAGAA TATCAAAAAG CCACCCTCTA CTTTAAGCAG CTTGATACCA TTTCTCCTGA 480

CTTTGAAGGC TATGAGTATG GGTACAGTCA GGCTTTACAT AAGGAACATC AAGTTCAAGA 540

AGCCCTGCGT ATCGCTAAGC AAGGATTAGA GAAAAATCCC TTTGAAACTC GCCTCTTGCT 600

AGCTGCTTCA CAATTTTCTT ATGAATTGCA TGATGCTAGT GGTGCAGAAA ATTATCTCCT 660

TACTGCAAAA GAAGACGCTG AGGATACAGA AGAAATCTTG CTTCGTTTAG CCACTATTTA 720

TCTGGAGCAG GAGCGTTATG AGGATATTCT AGACTTGCAG AGTGAGGAGC CAGAAAATCT 780

TTTGACCAAG TGGATGATTG CTCGTTCTTA TCAAGAAATG GACGATTTGG ATACTGCTTA 840

TGAGCATTAT CAAGAGTTGA CAGGAGATTT GAAGGACAAT CCAGAATTTC TGGAACACTA 900

TATCTATCTC TTGCGTTGAA TTGGGACATT TTGAAGAAGC AAAATCCCAT GCTC 954

(2) INFORMATION FOR SEQ ID NO:117:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 564 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:117:

CTATGAAACA TTTTGATACT ATTGTCATCG GTGGGGGACC TGCTGGTATG ATGGCTACGA 60

TTTCCAGTAG CTTTTATGGA CAGAAAACCC TCCTCATCGA AAAAAATCGG AAACTTGGAA 120

AAAAATTAGC TGGGACTGGT GGGGGACGTT GCAATGTGAC CAACAATGGT AGCTTAGACA 180

ACCTGCTAGC TGGAATTCCT GGAAACGGAC GCTTTCTTTA CAGTGTTTTC TCCCAGTTCG 240

ATAATCATGA CATCATCAAC TTTTTTACAG AAAATGGTGT TAAACTTAAG GTCGAAGACC 300

ACGGACGCGT CTTTCCAGCC AGTGACAAGT CTCGGACTAT TATCGAAGCT TTGGAAAAGA 360

AAATCACTGA ACTAGGTGGT CAAGTTGCTA CTCCAAATAG AAATCGTTTC TGTTAAAAAA 420

GTAGATGACC AGTTTGTCCT TAAGTCAGCG GATCAAACCT TCACTTGTGA GAAACTCATT 480 GTCACAACAG GTGGTAAGTC TTATCCTTCG ACTGGTTCGA CTGGTTTTGG TCACAATGCT 540 CCGCCATTTA AGCATACCAT CACG 564

(2) INFORMATION FOR SEQ ID NO:118:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 651 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118:

CTCCGTGGTC TTTTGGTTTG CTACGGGATG TAGGCAAAAG GCAAGTCCAT TTTATCAGCA 60

ATAATGGCTC CGTGTGGAAT CCCTGCTGTT GCAGTTCCTG CAATCACTTC TACTTCAGGA 120

AAGGCTTCTT TGATAGCTTC CACAAAACCA TTTTCAATTA GGGTACGAGT TTCTGGATAG 180

GCTAGTGTCA CACGATTATC AGTGTAAATC GGTGACTTGA TACCAGATGC CCAAGTGAAG 240

GGTTCCTCTG GTTTGAGGTA AACGGCTTGG ATTTTCAAGA GGTGGCTAGC GATATCTTTA 300

GCAAGTGTCA TGGTATTCTC CTTTTATTTT TCTAATCTAG TTCTTTAATT CCAGTCCTGT 360

GTCCATTCAT CCTTGATGGC ATGATAAGCT GCAACAGGAT CCTCAGCTTG GGTAATGGGA 420

CGTCCCACTA CGATATAGTC ACTGCCGATT TGATAGGCAT CAGCAGGTGT CATGACTCGT 480

TTTTGATCTC CAACTGCAAC ACCAGCTGGA CCAATCCCTG GTGTCCCGAC AGATAAAAAT 540

CTGGATTGGT AGCCCTGCTT GATGACTTTG TCACTTCCCT GAGCCGAGCC AAACCAACAC 600

CCATCCCAAA GCCCAAGCTT CAGCTGTCTT CCTTGGCATA GTTGAATCCA C 651

(2) INFORMATION FOR SEQ ID NO: 119:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 602 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119:

CTTAGTATCT AGAAAAGGAG AAATAAAATG GTTAAAGTAT TAGCAGCGTG CGGAAATGGA 60

ATGGGTTCAT CAATGGTTAT CAAGATGAAG GTTGAAAATG CTCTCCGTAA GCTTAATCAA 120

ACAGATTTTA CAGTCAATTC ATGCAGTGTC GGTGAAGCTA AAGGTTTAGC AGTAGGATAT 180

GACATCGTAA TCGCTTCTCT TCATTTGATT CAAGAATTGG AAGGGCGAAC TAATGGGAAG 240

TTAATTGGGC TTGATAACTT GATGGATGAT AAAGAAATCA CCGAAAAACT CAGTCAAGCA 300 ATACAGTAAA AGGTTGGAGG GGGCTGGACA CAAACTGAGA GTTATCGTTT CTGTCCTTCT 360

CCCTCTTTAA ATAAAGGAGG CAGATATGAA TTTAAAACAA GCTTTAATTG ACAACGACTC 420

GATCCGACTA GGTTTAGAAG CTAACGAATG GAAAGAAGCA GTCAAGGTAG CAGTAGATCC 480

CTTGATTGAA AGTGGGGCAA TTTTGCCAGA GTATTACGAT GCTATCATTG AATCGACTGA 540

AGAGTATGGG CCTTACTATA TCTTGATGCC AGGTATGGCT ATGCCCCACG CTAGACCTGA 600

AG 602

(2) INFORMATION FOR SEQ ID NO: 120:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 586 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 120:

ATTGGGAATT TTTGCAACTG CAATTGGTGC CCTCAGTAAT CTATAAAATA GATTCAAGAA 60

AATTTAGTGA CTGGGATTTC CCAGCCCTTT TTTAAAGTGA GAAGAAATAA TGAGTATGTT 120

TTTAGATACA GCTAAGATTA AGGTCAAGGC TGGTAATGGT GGCGATGGTA TGGTTGCCTT 180

TCGTCGTGAA AAATATGTCC CTAATGGAGG CCCTTGGGGT GGTGATGGTG GTCGTGGAGG 240

CAATGTGGTC TTCGTTGTAG ACGAAGGACT ACGTACCTTG ATGGATTTCC GCTACAATCG 300

TCATTTCAAG GCTGATTCTG GTGAAAAAGG GATGACCAAA GGGATGCATG GTCGTGGTGC 360

TGAGGACCTT AGAGTTCGAG TACCACAAGG TACGACTGTT CGTGATGCGG AGACTGGCAA 420

GGTTTTAACA GATTTGATTG AACATGGGCA AGAATTTATC GTTGCCCACG GTGGTCCGTG 480

GTGGACGTGG AAATATTCGT TTCGCGACAC CAAAAAATCC TGCACCGGAA ATCTCTGAAA 540

ATGGAGAACC AGGTTCAGGA ACGTGAGTTT ACAATTGGAA CTTAAA 586

(2) INFORMATION FOR SEQ ID NO: 121:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 680 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 121:

TTCGACAATC TTGCCCNNGA TCCAAGACAA CCACTTCTCT GTCCGCTCAG CAATAGTCAA 60 GCGGTGAGCA ATGAAAATC AAGGTCTTGT CCAAAGCCAT GAGATAATGG ACAATCCGTT 120 TTTTTGTCAA AATATCCAAA CTGTTAGTCG CCTCATCCAA AATCAAGACC GGCGCATCTG 180

TCAAGAGAGC ACGCGCCAAA GCGATTCTCT GACGTTGACC ACCTGAAATC CCTGCCCCAT 240

CCGAAGTCAA TTCTGTCTGG TAAATTTCAA GGTGGCATGG CGGCTTCGAG ATATTCCTCT 300

TCGGAATCTC TGAACCAAAT TCGGACCGGC CCGTTAAAGA TATCTTCCCT GTGTCGTCCC 360

CTCCCTTGGC TCCCAAAAGA AGATTCTCCA AAATCGTTCC GTTAAAGACA TAGGGCTGTG 420

GAGGCAGATA GATGATGTAC TGGCGTAGGG CTTTTTTATC AATCTGATTG AGATTGACAC 480

CACCCAGACT AATCTCCCCT TGACTTGGGT CGTAAAAATT AACCATCATC TTGGCCAAAG 540

TCGTCTTACC TGACCCTGAA ATCCCCACAA AAGCCACCTT AGACCCTTGG GGAACGGTTA 600

AATTGATATC CGACAAGACG TCTCGACCAT AGCCATACTT GTAATGAACC TGCTTGAAAG 660

TCATCTCTCC CTTCATCAAG 680

(2) INFORMATION FOR SEQ ID NO: 122:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 601 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 122:

CCAATTTGGA TTTGCGAGAA GGCGTTATTA TTTCAGATGC TGGTTCGACC AAGTCAACCA 60

TTGTGGATGC GGCGGAGCAG TATTTGGCTG GCAAGTCTGT TCGCTTTGTC GGGGCCCATC 120

CCATGGCTGG TAGTCACAAG ACAGGGGCTG CTTCGGCAGA TGTCAATCTT TTTGAAAATG 180

CCTATTATAT CTTTACAACC TTCCAAAGCC CTGAACAAGT CAAGGACAAC GCTTAAAGGA 240

AATGGGAAAG GATCTGCTTT CCAGGTCTTC ATGGCTCGTT TTATCGAGAT TGATGCCAAG 300

GAGCATGATC GTGTCACTTC TCAGATTAGC CATTTTCCTC ATATTTTGGC TTCTAGTCTC 360

ATGGAGCAGA CTGCGGTCTA TGCTCAAGAG CATGAGAATG GCAAGGCGCT TTGCGGCAGG 420

TGGTTTTCGA GATATGACCC GAATTGCGGA AAGCGAGCCA GGAATGTGGA CCTCCATTCT 480

CTTGTCCAAT AGCGAGACCA TTCTGGATAG AATTGAGGAT TTCAAGGAAC GTTTGGAAGC 540

GATTGGTCAG GCCATTAGTA AGGGAGATGA AGAGCAAATT TGGAACTTTT TTAACCAAGC 600

G 601

(2) INFORMATION FOR SEQ ID NO: 123:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 514 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123:

CTGGCTCATC AGGGGCAGGA TATTTATGAT TTCCCTCGTG CTATGATTAA GGAAGATAAT 60

CTGGAGTTTT CATTCTCTGG TTTGAAATCT GCCTTTATCA ATCTTCACCA CAATGCCGAG 120

CAAAAGGGAG AAAGTCTGTC TACAGAGGAT TTGTGTGCTT CCTTCCAAGC AGCTGTACTG 180

GATATTCTCA TGGCAAAAAC CAAGAAGGCT TTGGAGAAAT ATCCTGTTAA AACCCTGGTT 240

GTGGCAGGTG GTGTGGCAGC CAATAAAGGT CTCAGAGAAC GCCTAGCAGC CGAGGTTACA 300

GATGTCAAGG TCATCATTCC ACCTCTGCGC CTCTGCGGAG ACAATGCAGG TATGATTGCT 360

TATGCCAGTG TCAGCGAGTG GAACAAAGAA AACTTTGCAA ACTTGGACCT CAATGCCAAA 420

CCAAGCCTCG CTTTTGATAC CATGGAATAA AGAGTGGCTC TTTGTCAAGT GTAGTGGGTA 480

GGCGAAAAGC TACAATCTGG AGANTACGAA ATTC 514

(2) INFORMATION FOR SEQ ID NO: 124:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 521 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124:

CTTGGATTAT AAAATACAAT CGGCAAGATC ATAAGTCCCA AGCCTAAAAA TATATAGAAA 60

GGGGGTCACC TTCCAAAGAA ATTCTGTATT AAAGAGCATG ACCACAAAAC CAATCACAAG 120

CCCCAAGGCA ATCCAGGCGA CCTGCTGCCC TAAAATGGGC AGAATATTAT TGGGGTAATC 180

ATGACTAACG GCTATATAGA TAGCCACCAC ACCGATGACC AGTAGAAAAA ATACTGGCAA 240

GAGCAAACTG TAATCGACTC TTGAGTCGAG AGAACGTTTC ATATAAACTA ACCTTATACT 300

TTCATACAAT ACTATTTATC AAAGTTCATT AAAAAATCTA TCAATAGCCT CGTCAACTTC 360

GGATCGAGAG ATGGTTTTAA CAGTCGCTTC TTCTGCTAGA GATGCTACTA TTTGTTTGCC 420

GTATCGTTTT CCGACGATTC TCCTATCCAA AATAAGAGTT AAGGAACGTT GGTATTCACG 480

TCTCATACTT CTTCCCAAAG CCTGTTTTAA ACGAATAATG G 521

(2) INFORMATION FOR SEQ ID NO: 125:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 599 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125:

CTTGCCTGAT GACATCATTG ACTCTTTTTG GTATATCATC GACCATTTCT TAAAAAATGT 60

CTTTGAATTG GAAGAAGAAC TCGAGTTTCA ATTGCTTAAT AACCAAGGAA AGATTACCTT 120

CCACTTTTCA AGTCAACACC TCCCTACAGC CATTGATTTT GACTTTAACC ATCCTTTCGA 180

CCCTCGTTAT CCCCCAAGAG TACTGGTTTT AGACATGGAC GGTAGAGAAA CTATCCTCCT 240

CCCAGAAGAA AATGACCTAT TTTAAAAACT CTAGCCTTCA GTTGCAAGTG ACTGAAAACT 300

AGAGTTTTTC TATTTTTTCA AAGCATCATA CAAGTTGCGG ATCGGTTGTT TTAATATCGG 360

ATGGATAAAA TGAGGCGCAA TTTCCTGTAA GGACTCAAGG ACAAAAAGGC GTTCCCGCTA 420

TGTTAAGGGA TGAGGCAATA TGAGGTCGTC TGTATAAAGG ATCTGGTCCT CCCACAAAGA 480

GCAAGTCCCA AATCAATCCA AACGAAGTCC CCCAATGCAC TTCTCTCACC CGTCCCCAGC 540

TCTTGACTCC AATGGCTAAC AAGGTTTCNT AACAATTCTT GTTGCTGGTA GCCAAGTTC 599

(2) INFORMATION FOR SEQ ID NO:126:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 564 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:126:

CTATGGGTAA AAAGGATGCC TCTGCTATGC ATGAGATGAG GGCTTCCTTT ATTCAAGGCT 60

CCATAGAAGC AGGCCATACT GCGGAAAAAT CAGAGCAGGT TTTTGATGTT ATGGAGAAGT 120

TTGCAGGTTA TGGATTTAAT AGATCTCATG CCTACGCCTA CTCAGCCTTG GCCTTCCAGT 180

TGGCTTATTT CAAAACGCAT TATCCAGCCA TTTTTTATCA GGTCATGTTA AATTATTCCA 240

ACAGTGATTA CTTAATAGAT GCACTTGAAG CAGGTTTTGA AGTAGCCTCT CTATCCATCA 300

ATACTATTCC CTATCACGAT AAAATTGCCA ACAAGTCTAT CTATATAGGT TTGAAATCGA 360

TTAAGGGGCT CCAGCAAGGA CTTGGCGCTT TGGATTATTG AACATAGACC TTATTCTAAC 420

ATTGAAGATT TTATAGCTAA ATTACCTGAG AATTATCTGA AACTTCCTCC TGCTAGAACC 480

TTTGGTAAAA GTTGGTCTTT TCGATTCATT TGAAAAAAAT CGTCCAAAAG TATTTAATAA 540

CTTAGCTATC TATTGAATTG TGAA 564

(2) INFORMATION FOR SEQ ID NO: 127:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 618 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 127:

ACTAATCACT TACTACGTAG CTTCTGACTA TCTACCTCTA CTAGATAAAG GACAAACTGT 60

AAGATTAAAA CTGGAGAAGN TTGGAAATCA CGGCATTACC ACCATCGGCC AACTTCAGAC 120

AATTGATCAA ACTCCTACCA GAACAGAGCA AGGCAATCTC TTTAAATTAA CCGCTCTTGC 180

AAAACTATCT AATGAGGATA GTAAACTCAT CCAATATGGC TTACAAGGTC GCGTCACTAG 240

TGTAACTGCA AAGAAAACAT ATTTTGATTA TTTCAAAGAT AAAATTTTAA CCCATTCTGA 300

TTAATTTTCA GATAACACTC TA AACTATT TATTATCTTA TCAAAAAGGA GAATCATAAC 360

ATGGATAAGA AACAAAACCT AACTTCATTT CAAGAACTAA CAACTACCGA ACTCAACCAA 420

ATTACAGGTG GAGAATGGTG GGAAGAACTC TTACATGAAA CAATTTTAAG TAAATTTAAA 480

ATCACAAAAG CACTTGAACT ACCTATTCAG CTATAAAAAC AAGACCGAGA AACAAGAACT 540

CTCGGTCTTG TTTTTTATCA TTCTGCATGT ATCACAGTAA GTACCTGACG AAAGACTTGA 600

TTTTGGCGAG GTAGTATT 618

(2) INFORMATION FOR SEQ ID NO: 128:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 549 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 128:

CAGGGGATGC CAGTTGATTT GCTTCAAGTT GACTTGACTC GTACTTGGGA AATCCTCGGA 60

GAAATCACTG GGGATGCTGC TCCAGATGAA CTCATCACCC AACTCTTTAG CCAATTCTGT 120

TTAGGAAAAT AAGAAAAATC CATGATCCTT CATTCGGTCA TGGATTTTAT TGTCTTTATT 180

AGTAATCTGG TCTTAAGACC CCTGTTACAG TTGCCTTAGT TGCTTCGTAG TCGCCATCTA 240

CGACAACCTT GATAATGCGT TTGACATCTT CTTCTGGTGC TGGAACAAGA GGTAGACGAG 300

TGGGTCCAGC TTCAAATCCC ATATAGTTAA GAATTGCCTT AACTGGAGCA GGACTTGGAT 360

AAGAGAAGAG AGCATTAACC TTAGGAATGA ATTTACGCTG AATTGCTGCG GCTTTCTTCA 420

TATCGCTTTC TGCAATGGCA GTAAACATCT CGTGCATTTC ATCCCCATTT GTATGAGAAG 480

CAACAGAAAT AACCCATCCG CCCCAAGGTT CATGGCATGG AAAGCATCTC CATCCTCACC 540

TGTATAAAT 549

(2) INFORMATION FOR SEQ ID NO: 129:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 455 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:129:

CTGGCTANCA AAATCATACT CATAATCCTT AACACCGACA GAGATAGAAG CAATGAGCCC 60

TTGATCGTGC ATTCGTTTAA TAAAAGGAAT GCGTCCTGCC TCATCAAAAC GGTGCATAAG 120

TGTACAAGTA ACCACCTTTA GCCAGTTGCT CTGCTACATT TTCATCCAAA ATCGTCTGCA 180

TATTCGCTGG CACAACAGGT AGTTTAAAGG TGTGATTTCC TAAAGTGACA CTTGTATCCG 240

CTTCTGCACG GCTTTTAATG ACACATTTAT TTGGAATCAA TTGAATATCT TCGTAATCAA 300

AAATTGGAAA TTCATTTAAC ATATCGATGT CTCGTTTCTT TTGTAATGAC CTACCTATGC 360

TCTCGCATCA CTACGCCTTT TCCGACGTTT CCCTTAAATT TATTATAAAC CAAAAGTACA 420

GTTTTTGTCA AATTATTTCA TGAATNAAAT ATATC 455

(2) INFORMATION FOR SEQ ID NO: 130:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 776 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:130:

CTCCTGGGTT TTGATTAACT CTAGGGTTGC CAAAAAGAGG GTGATGACTT CTTGGACATT 60

CTGGGCTTCC TTGAACAAAT CCTGCAAGCG CAATTGATTT CGTCCAATCA AGGATTCTTT 120

CACAATAATC ATCATGTCCT CAATCTTATA CTCATCCCGC AAGATAGTCG TGTGATTTTG 180

TGCAAACTCC TCTTTTTTCT TGGCTAGGAT ATTTGAAAAA GCCAAAAAGA GGTCAATGGT 240

CGTCTTGTCA TGCACAAGCT CCGCATCTTC GTAAATCAAC TCTATCGGCG CTTTGGAATA 300

ATACTGGGCC CGTTTCTTGG TGCTTGGCTT CCAAGTGCTC ACCCAAGAGC TTGAACTTGC 360

GATATTCTTC GATTTGAGAG AGGAGGTCCT GCTCCAGGTC ATCCCCCAAG TCTGTCACTT 420

CTGCTACCTT CGGAAGGAGT TTACGACTCT TAATCAGCAT GAGCTGACTA GCCATGACCA 480

TGTACTCACC CGTCACTTCC AGACGCATGG CCTGCAGGGT TGAGACATAG GCTAGATACT 540

GTTCGATGAC TTCCGTAATG GGCACATCGT AGATATCCAT CTGGTACTTA GAAACCAGAT 600

GCAAGAGTAA GTCCAGGGGT CCTTCAAAAT CTTTTAATTT AATATCCATT ATCTATATTT 660

TTCTAAGGTC AGGACTGTTT TTAATCCTAA TTTTTTTGCA ATTTCGTACA AATCGACCTT 720

GTTTTCTATT TGTCCTTAGA ATAAACTGTT CACGTAAGAC TTGAGATCGA ATTCCT 776

(2) INFORMATION FOR SEQ ID NO:131: ( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 715 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 131:

ATTGATACCN ATTGTACAGG ACAACTTATT TTGGAGCGCC ATAGCAGGGA TANGGTTAGC 60

AATAGATGCG NTGACCATAG AAACGTTTNT TAGCCAATAC ATAACCTGCT AGAGATGAGG 120

TTGCACAAAC TAAGAACATG GTTACCAATG AGATAAATAC TGAGTTCCAC ATCCATTGCA 180

AGGCAGGGTT CTGCACCATG AGTTGTTGGA AGTTTTCCAT GGTTGGCATT TTAGGGAACC 240

ACTGAGGAGG AATAACAATT GTATCAGGTT GTGATTTGAA TGCCCCTGTC AAAATCCAGT 300

AGAATGGAAA GATGNACAGC ACAGTCAACA AGAGCAAAAT GATTGTTGAA ATNACAGTAA 360

AGGCTGTTAA TGGTTTTTTT TCTGTAGATT GCATAGCTGT CTCCTTTCTT TAGTATTCTA 420

CGTCGTTTCC AAGTACTTTA AATTGAACAA AGCTTACGAT AGCAATCATG ACTGCCAAGA 480

AGACACCAAT TGTGTTGGCA TAGCCGTATT CTGTCAATTG GAAGGCTTTT TCGTAAAGGT 540

AGTACATCAA GGTACTTGTT GAGTAGTTTG GACCACCAGA TGTCAAAAGC TGAATCAAGG 600

CGAAACACTG GAATGAGTTA ATTGTTGTGA TGATTGCAAT ATAAAGAGTT GTTGGAAGAA 660

GGCTTGGCCA TTTAATCTTC CAAAAAACTT GAAACTCAGT TGCACCATCA ACACG 715

(2) INFORMATION FOR SEQ ID NO: 132:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 485 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132:

CTGGGCTGAG TTTTCCAGAT ACAAATACTG CAACCGCAAC TGCAATCCCC CAACCCATAG 60

TAATCACAAT CCAACCTGCA CTGTTGCTCT TGGTTTTTGG AAGAACCACA CCTGCAACAA 120

CACCATTTCC TAGAAGAATC AGGATTAAAG TCCCTAAAAA TTCTCCAAAT AATTCACTCA 180

TCATTTTTCT GTCTCCATTA AAAAGAAGGG GCGGGCGACA AGGATTGCTA CCCTCCACCT 240

CTTTTATTTT TTCTTAATTT TTTAATTCTG CTAAGTCGTT TTGAGCAAGA GCTGCTTTTA 300

CATCAGCACG GTAAGTTGCT TTTTCTTCTT CTGTCCAGTC ATAGAATCGT CCCATTTCAT 360

CCAAAACTGG CTCAACGATA CTATCCAAGC TATCACGCAT AAAGAGCATG TGATTGGTAC 420

GACGAAGAAG GAAGTCAACT GGGCTAAGAG TCAACTCATT GCGCATTGCA TAGTGAAGGG 480 AC AAG 485

(2) INFORMATION FOR SEQ ID NO:133:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 670 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:133:

CTTAATTATA ACTTAAACAC AAAAGTTTTA CACAAACTGT GGATAACTCT TTTGAAACTG 60

TGATTTTCTT AATTGAAATC TATTTTTTAT TTTGTGAATA AGATGTGAAA AAATAGAGAA 120

TATGTTAGAA TAGAGTCATG AAAATTAAAG TTGTAACAGT TGGGAAACTG AAAGAAAAGT 180

ATTTAAAAGA TGGTATCGCA GAGTATTCAA AACGAATTTC TAGATTTGCT AAGTTTGAAA 240

TGATTGAGTT ATCAGATGAA AAAACACCAG ATAAGGCCAG TGAATCAGAA AATCAAAAGA 300

TTTTAGAAAT AGAAGGTCAG AGAATTTTAT CAAAAATTGC TGACCGTGAT TTCGTTATTG 360

TGTTAGCCAT TGAAGGGAAA ACTTTCTTCT CAGAAGAATT TAGTAAGCAG TTAGAAGAAA 420

CTTCTATAAA AGGANTTTCT ACTCTTACTT TTATTATTGG GGGAAGTTTA GGATTGTCAT 480

CATCTGTAAA AAATAGAGCC AATCTTTCTG TCAGTTTTGG TCGCCTAACC TTGCCTCATC 540

AGTTAATGAG ACTAGTTCTT GTTGAACAAA TCTATCGCGC TTTTACGATT CAGCAGGGAT 600

TCCCCTACCA TAAATAGAGA ATTGACTTTT AATTGAATTT TTGGTAGAAT AATTGTGTTA 660

GGTCTCATAG 670

(2) INFORMATION FOR SEQ ID NO: 134:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 506 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:134:

CTATAATTTT AT AGCTGTA TTCCAGTCGT CACGACCAAA CTCTGTTACA GGGACACGAA 60

TGTCAAAACG GTTCTCAATC TCCACAATCA ACTCAACCGT TCCCATACTA TCCAAGACAC 120

CTGCATCAAA AAGATCTTCA TCCATCATGT CAGAAACATC TTCCATAAAC AACTCATCAA 180

TAATTTCGAT AACTTCTGAT TTGATATCCA TATTTTATTT CCTTTTATTT TTTAAACCAT 240

AGATTATTCA AGAATCCAGA AAAGATTAAG AATGACAACA TGACAACATG GAAAGTGACA 300 ACCATGCCAA GCAACTGAAT CCAGCGATTC TCAGGTAGGG CAGCCTTCCC TGCTTTTTTC 360

CGTTCCTTAT TGAGCGTTTT TTTCTTGCGA ACCCAGGCAT CATTGATGAA CAAGCCTAAG 420

TCCATGAAAG AGTCCCATAG GCGATATAGT ACCAGGTCAC ACCATGCCAA AATCCCCATA 480

ATCCAGCATA TTTACAATGT AAGATC 506

(2) INFORMATION FOR SEQ ID NO:135:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 921 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:135:

ATGGTTCGAC CCACAAATAT GTTTTGCGAA TCATTGACCA TTCTATGATT TACGTTGCCA 60

TTGCCGGCTC ATACACGCCC GTTGTCTTGA CCTTGATGAA TAACTGGTTT GGCTATCTGA 120

TTATTGTCAT CCAATGGGGA ACGACCATCT TTGGTATTCT CTATAAAATC TTTGCTAAAA 180

AGGTCAATGA GAAATTTAGC CTTGCTCTTT ACCTGATTAT GGGCTGGTTG GTTCTGGCTA 240

TCATTCCTGC CATTATCAGT CAAACNACAC CCGTTTTCTG GATTCTCATG GTAACTGGCG 300

GACTCTGTTA TACAGTTGGA GCTGATTGAT AGCCTTTATG CATTGAAATT TGACAGTTTG 360

ACTTATGAAA ATAAAGCAGA GGTTATGGAC TTTATCAAGG CTCGTGTTGA TAAGATGATG 420

GGCTCTACTC CAAAAGATAT CAAGGGAAGC AGTTCTTGCA GGTTCAAACT TTGTTGTGGC 480

AGATATGTTT GGAAGCAGCA AGTGCTCTCG TAGAAGTAAG CAAGGAAGAA GATTTTAAAC 540

CATCTGTTGA ATCACTTTCT CGTGCCTTTA ACCTGGCTGA GAAGGCAGAA GGGGTTGCTA 600

CAGTTGATTC AGCACTATTT GAGAATGACC AAGAAAAAGC TTTGGCAGAA GCAGTAGAAA 660

CACTCGTTTT ATCAGGACCT GCAAGTCAGC AATTGAAACA ACTCTTTGCG CTTAGCCCAG 720

TCATTGATGC TTTCTTTGAA AATACTATGG TAATGGCTGA AGATCAGGCT GTCCGTCAAA 780

ATCGTTTGGC AATCTTGTCA CAACTAACCA AGAAAGCAGC TAAGTTTGCT TGTTTTAACC 840

AAATTAACAC TAAATAAAAT TTGATAAACG GACTTTATCT TATTACAAAG GAGAAGAAAT 900

GGATCCGAAN ANATTGCTCG T 921

(2) INFORMATION FOR SEQ ID NO: 136:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 571 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 136:

CTTGGCAACA GGCTCTTTTT GTATTGCGTT TATTAAGAAA AACAAAAAAC ATCGATATAA 60

CATTTAACTA AAAATTATTG TATGTTATCT CCCTTAATTA GGAATGATAA GGGAATAACT 120

AGAAAGATTT GTGAATACAA ACTATTTCTG ATATACAAAA TATACAGTAA TAATGAATGA 180

TGGGAGATGG GATGAAAGAA TTTCAATTTG AGAGAAAGCA GCGTTTTTCT TTGAGGCCAT 240

ATGCAATAGG AGCTTGTTCG GTCTTGCTAG GAACGAGTTT ATTTTTTGCT GGTATGGGTG 300

CTCAGCCTGT ACAGGATACA GAAACGAGTT CAGCACTAAT TTCAAGTCAT TATTTGGATG 360

AGCAGGATTT ATCTGAAAAG CTGAAATCTG AGTTGCAATG GTTTGAATTA GAAAACAAGC 420

TTTTGAACTT ATGGGAACAT TAGGTTACTA TGAAGGATTT GTTCCTTATG TTTCAAATCA 480

ATACAAAAAC CAAGCTGAAG AAGAAGGCAA ACCGCTATCT GATAAATATA TTTTCGAAAA 540

ATCTTAAGAA AAACATATGC ACCTTCAAAA A 571

(2) INFORMATION FOR SEQ ID NO: 137:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 611 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 137:

GTATCAACTC CAAAGAGCAA GTGACTGTCA AAGTTGTAAC AGATGCGGCC AAGAAGCTCA 60

TGGGTGATAA GATTGCTCGC CAGAAAGAAC GTGGGATTCA GATTGANACC TTGCGNACCA 120

TGATTATNGG GATTCCANAC GNTGGTAAAT CCACTCTGAT GAACCGTTTG GCTGGTAAAA 180

AGATTGCTGT TGTTGGAAAC AAGCCAGGGG TCACAAAAGG TCAACAATGG CTTAAAACCA 240

ATAAAGATCT GGAAATACTT GGATACACCG GGGATTCTCT GGCCTATAGT TTGAGGATGA 300

AACTGTTGCA CTTAAGTTGG CATTGACTGG AGCTATCAAG GATCAGTTGC TTCCTATGGA 360

TGAGGTTACC ATTTTTGGTA TCAATTATTT CAAAGAACAT TATCCAGAAA AGCTGGCTGA 420

ACGCTTCAAA CAAATGAAAA TTGAAGAAGA AGCGCCTGTG ATTATTATGG ATATGACCCG 480

CGCCCTCGGT TTCCGTGATG ACTATGACCG TTTTTACAGT CTCTTCCGTG AAGGAAGTCC 540

GTGATGGCAG ACTCGGTAAC TATACCTTAG ATACATTGGA AGACCTCGAT GGCNACGATT 600

GAACTAAGTC C 611

(2) INFORMATION FOR SEQ ID NO: 138:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1054 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 138:

TTGCTAAAGC AGCCATGATG ANGGCACTCC ATAAGGATAA GTACCACCAA GCAGCAGCAG 60

ANGACCATAA TCTCCTTTAT GACTTGAACG AGAACGTTCA ATAATAACTT TTTCTAGTAA 120

GGTTTGATTA ATCACTTTCA TCCTTTTTCC CTCTCACTTT TATTATACAA CAAAAAGGAG 180

ACGCAGACCT CCTTTTGTAA TCTTATATCT AAAATTTAAT ATTCATTTCT GCCATTTTAG 240

ATATAGCTAT AGAAAATACA CTCTATTAAT CGAATGTTTC TCTTATTTTC TATCCAATGT 300

CCGAAGTGCT GCTTGATAAG TTTGCTCCAT CAGCATGGTA ATGGTCATAG GACCGACACC 360

TCCAGGGACT GGCGTGATAT GGCTAGCAAG TGGTGCAACT GCCTCATAAT CAACATCTCC 420

ACAGAGCTTC CCATTTTCAT CTCGGTTCAT CCCAACGTCA ATGACAACCG CACCTGGTTT 480

GACAAAGTCA GCAGTCACAA ACTTGGCGCG GCCGATTGCG ACTACAAGAA TATCTGCTTT 540

AGCAGCCACC TTGGCAAGAT TATGAGTTCG TGAGTGGGCC AAGGTTACTG TCGCATTTTT 600

AGCCAAAAGA AGCTGAGCCA TAGGTTTTCC AACGATATTT GAACGACCGA TTACGACCGC 660

ATTTTTACCT TCCAAGTCAA TCCCATATTC ATGAAACATT TCCATAATTC CTGCAGGTGT 720

CGAGGGAATC ATGACTGGAT GTCCAGACCA AAGACGTCCC ATGTTTAGGG GATGGAAACC 780

ATCCACATCC TTTTCTGGGT CAATGGCTAA TAAAACCGCC TCTTCATCGA TATGTTTTGG 840

TAATGGCAAC TGGACCAAAA TCCCATGCCA AGCTGGATCC CTGATTATAT TTAGCAATCA 900

GGTCTAACAA TTCCTCTTGA GTTAATGGTC TCTGGAACTC GCACTACTTC GCTACGGGAA 960

CCAGCCGCAA GAGCTGACCT CTCCTTGTTG CGAACGTTAA ACTTGGCTGG CTGGATTATC 1020

CCCAACCAAA ATCACTACCA ACCAGGCACT AGAG 1054

(2) INFORMATION FOR SEQ ID NO: 139:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 598 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 139:

CTGAACTGGA TTTTGCTACA AGGTCTGATT TGTCAAAGAG ATGCGAGTTA TGATATGAAG 60

CAGGATGATT TGGATAAGGT AGCAGATTAT CTCTTCAAAA CAGAAGAATG GACCATGTAT 120

GAGTTGATTC TTTTCGGTAA CCTCTATAGT TTCTACGATG TAGACTATGT CACTCGGATT 180

GGTAGAGAAG TTATGGAGAG GGAGGAATTT TACCAAGAGA TTAGTCGCCA TAAGAGATTA 240

GTGTTGATTT TGGCCCTCAA TTGTTACCAG CATTGTTTAG AGCATTCTTC TTTTTATAAT 300

GCCAACTATT TTGAGGCTTA TACAGAGAAG ATTATTGACA AAGGTATTAA GCTTTATGAG 360

CGTAATGTTT TCCATTATTT AAAAGGTTTT GCCTTATATC AAAAAGGACA GTGTAAAGAA 420

GGCTGTAAGC AGATGCAAGA GACCATGCAT ATTTTTGATG TGTTAGGTCT TCCAGAGCAA 480 GTTAGCCTAT TATCAGGAAC ACTACGAAAA ATTTGTCAAA AGTTAATTTT CCCAAATAAG 540 GGAAAAAATA AAAAGCTCCT TTCGGTTTTG ATACAATAGT TTCAAAATTT GAGAGGAG 598

(2) INFORMATION FOR SEQ ID NO:140:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:140:

CTACTTCCCG GCCGAGTCGA TTCTCCGCCG ATATCGAGCA TACTGGCTCC TTCTGTTATC 60

AATTTACGAG CCTGCTGGAG CGCCTGCTCA AGAGCAAAAA ATTGACCACC GTCCGAAAAG 120

GAGTCTGGGG TTACATTGAT AATTCCGCAA ATAGCTGTCT TTGCATGAGT GGCTTTACTG 180

GACATATCGG TCACTCCCTC AAGGCTATTC ATCATATTAT TTCTCTATTT TACCATAAAA 240

AGAAAAAGAT GGACACGATT TCATTCATCT TTCTCCCAGT AGAAACAAGT AAGCAATTGT 300

CAATAATCTT AAACAGAAAT CCCTAATGTC CGACTCATAA TCACCACAAG AGCCAACAAA 360

CAGAAAGCAA TCCCATTAAC AATCATGTGA AGTAAGATCG ACATTTCCAA ACGTTGGGTC 420

TTGTAGGCTG TCCAAGATAG AACTGTCGAC ATACCTCCAT AAATCAATAA AGAAGGTAAA 480

TTACTTGGTT GATGTAATAA AGCAAACACA ATCGTACCGA CTACAAAT 528

(2) INFORMATION FOR SEQ ID NO: 141:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 505 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 141:

CTATGAGAGA GAATGACCTT CTCTTGATTA CTGCGGACCA TGGAAATGAC CCAACGTATG 60

CAGGAACGGA TCACACTCGG GAATATATTC CATTGTTGGC CTATAGCCCT GCCTTTAAAG 120

GAAATGGTCT CATTCCAGTA GGACATTTTG CAGATATTTC AGCGACTGTT GCCGATAACT 180

TTGGTGTGGA AACTGCTATG ATTGGGGAAA GTTTCTTAGA TAAATTGGTA TAAGATGACG 240

CGCTATGCTT TGCTGGTGAG AGGTATCAAT GTTGGTGGTA AGAATAAGGT CGTCATGGCG 300

GAGCTTCGTC AAGAATTGAC AAACTTGGGA CTGGAAAAAG GTTGAGAGCT ACATCAATAG 360

TGGCAATATT TTCCTTTACT TCGATAGATT CCAAAGCCCC AATTGGTTGA AAAAGCTAGA 420 GACTTTCTTT GCAGTCCATT ATCCATTTAT TCCAGAACTT TTTCCTTTAC TGAGTCTAGA 480 GGACTTTGAA GGGCGGAACT TGAAA 505

(2) INFORMATION FOR SEQ ID NO: 142:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 876 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 142:

CTATTTTCTC ATCTTTTTTA GACTGGTAAT GTATCCCCTA GAGTTTCATT GTTAAGACCT 60

GTCGTATTGA CAACAGTGGA TCCTGATTCC CCATTCCAAG AGTTTTGCCC GCATCATATN 120

GACGAAATCT TTTTCTGAGC CAGCAATTTT CTCAGCTAGG GCAATAGCGG CGCTGTTGGC 180

ACTAGATACC AGAGTTGCTT CAAGCAACTC TTCGACAGTA TAATTACGGG CCTCCATAGG 240

AATATTACTG GCTTCAGAAT TTGTCGTCAA TTGATAAGGA TAATCAGAAA TATCTACAGG 300

AGTGGAGAGG GTAATACTTC CGTTTTCCAA AGCTTCATAG ACCAGATAAA CAGTAATCAA 360

TTTTGTTATG GAAGCAATTT CGACAGGTGG CGTTGCATCC TTCTCATAGA GAATTTTACC 420

AGTATTTGCC TCAACAGCAA TCGCATGTTT AGCGGCAATG GTAAAATCTT GAGCAACAGC 480

AGTAGAAGCA CCCCCTAAAA GAGAGACAGT TAACAAAGTT AAAAATATTT TTTTCATAGT 540

AGTCTTATTC TATCATAAAG AAAAAAAATA TTCTTGCTTT AATAATTCAT CTGTTAAGCT 600

TTTTGAAAAT ATGGTAAAAT AAAGTGAGGG AGGTAACTCA TGTTTCGTAG AAATAAATTA 660

TTTTTTTGGA CCACAGAAAT TTTACTCTTA ACCATCATCT TTTACCTATG GAGACAGATG 720

GGGTCTTTGA TTAACCCTTT TGTTAGCGTG CTTAATACAA TTATGATTCC ATTTTTATTA 780

GGGGGCTTTC TTTATTATTT GACAAACCCT ATTGTTACTT TCTTAAATAA AGTCTGTAAA 840

CTCAATCGTT TGCTTGGTAT TTTAATTACC TTGTGT 876

(2) INFORMATION FOR SEQ ID NO: 143 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 521 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:143:

CTTGTCAAAT GCCATGGAAG GGGTTCTTTA CTTCCTCAAA CCAGACTTTT CAAAACTGAC 60 TAGCGCTGAT CTCCTCTATG CTCTGGGACA ATCTTTCTTT GCCCTCTCAC TAGGGGTTAC 120

AGACATGTTG ACCTATGCTT CTTACTTGGA CAAGAAAACC AATCTAGTCC AGTCAGGAAT 180

CTCCATCGTA ACCATGAATA TCTCGATAGT CCATCATGGA AGGTCTAGCC ATTTTCCCAG 240

CCATGTCAGC CTTCAATATC CACTCTGAAA GGGGACCCAG CCTGCTCTTT ATCGTCTTGC 300

CTCAACTCTT TGACAAGATG CCTTTTGGAA CCATTTGCTA CGTCCTCTTC CTCTTTGCAA 360

CTGTCACTTC TTCTGTCGGT GATGCTGGAG ATCAATGTGG GCAATGTCAC CAACCAGGAT 420

AACAGCAAAC GTGCCAAATG GAGTGTTATT TTAGGAATTT TGACCTTTGT CTTTGGCATT 480

CCTTCAGCCC TATCTTACGG TGTCATGGCG GATGTTCACA T 521

(2) INFORMATION FOR SEQ ID NO: 144:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 553 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:144:

CTGCAGACAA TAACTTGGTT AGCTTAACGG CTCTTGAGGA TTCATCCAAG GATGTAACCT 60

TTACCAGTTC GGCTTTCAAT CTAAAAGAAG GGCGACACCT TCAAAAAGGG GATTCCAAGA 120

AAATCCTTAT CCACGAAGAA TTGGCTAAGA AGAACGGTCT TTCACTTCAT GACAAGATTG 180

GCTTGGATGC TGGTCAGTCT GAATCTGGAA AAGGACAAAC AGTAGAGTTT GAGATTATCG 240

GCATCTTTCC TGGTAAAAAA CAAGAGAAAT TCACAGGCTT GTCTTCTGAC TTCAGTGAAA 300

ATCAAGTCTT TACAGATTAT GAAAGTAGCC AAACCCTTTT GGGCAATAGT GAAGCTCAAG 360

TCAGTGCAGC ACGCTTCTAT GTTAGAAAAT CCTAAGGAAA TGGACGGACT CATGAAGCAG 420

GTAGAAAACT TGGCCTTGGA AAATCAAGGC TACCAAGTCG AAAAGGAAAA CAAGGCTTTT 480

GAACAAATCA AAGACTCAGT TGCAACTTTC CAAACCTTCC TGACCATCTT CCTTTATGGA 540

TGTTGATAGC AGA 553

(2) INFORMATION FOR SEQ ID NO:145:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 523 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:145: CTATGGATGC GGAAGTTTCT AAGAACCTTC GCTTGATCCT TGAGCGTAAA GGAATGACCA 60

TCTTGACTGG TACTAAACTG CAAGAAATCA TTGAGGAAAA TGGTCAACTT CGTATCAAGG 120

TTGAAGGAAA AGACAATATC ATCGCAAGCA AAGCTCTTCT TTCAATTGGT CGTATGCCAG 180

ACCTTGAAGG TATTGGAGAG GTTGAGTTTG AATTGGATCG TGGTTGTATC AAGGTCAATG 240

AATACATGGA AACTTCAGTT CCACGCATTT ATGCCACCAG GTGACATCAA CGGTACTAAG 300

ATGTTGGCTC ACGCAGCTTT CCGCATGGGT GAAGTTTCCG CTGAAAATGC CCTTAAAGGA 360

AATCATGCAG TTGCCAAATT GAATTTGACT CCTGCAGCCA TCTACACTCT CCCTGAAGTA 420

GCAGCAGTAG GTTTGACAGA AGAACAAGCC CGTGAGAAAT ACGATGTTGC CATCGGTAAG 480

TTTAACTTTG CTGCTAACGG TCGTGCTATT GCATCTGACG CAG 523

(2) INFORMATION FOR SEQ ID NO: 146:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 508 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 146:

CTGCAGGTGG AATTATGAAT GTCGGATATG AAAAAGCATT CTTGATGCAG ACATCGTTAA 60

ATTTGCCAAC TTCTGAAATT ATCTCGACAT ATGTCTATAA AGTTGGTCTT GTATCAGGAG 120

ACTATTCTTA CTCAACAGCG GTTGGTTTGT TTAATGCAGT GATTAACGTA GTATTGCTTG 180

TTGCAGTTAA CCAAATCGTT AAACGCATGA ATAATGGTGA AGGAATTTAA GGAGGAAAGT 240

ATGAAAAATT CGATTATGGA TACAAAATTT GAT GACGTA TCTTACTCTT AAATAAAATC 300

ATTATTGTCT TTATCGTTTT GATGACTTTG CTTCCTTTAC TTTATATCGT CGTAGCATCC 360

TTTATGGATC CTAAGGTTCT GGTTAGTAGA GGGATTAGCT TTAATCCAGC CGATTGGACT 420

GTAGAAGGTT ACCAGCGTGT TATTCAGTGA CCAATCTATT CTAAGAAGTT TTATCAATTC 480

CCTACTATAC TCTTTTGGAT TTGCAGCT 508

(2) INFORMATION FOR SEQ ID NO: 147:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 147: CTAAAAAGAA CCAGATGGAT CTTGTGATGA ATTTACATCA TTTTGATTTA CCAGTGGAAC 60

TTCTTCAAAA ATACGGTGGT TGGGAAAGCA AACATGTAGT GGAGTTATTC GTGAAGTTTG 120

CCAAGACTGC TTTCAACATG CTTTGGAGAT AAGGTTCATT ACTGGACAAC TTTCAATGAG 180

CCAATGGTCA TTCCAGAAGC AGGATACTTA TATGCTTTCC ATTATCCAAA TCTAAAAGGA 2 0

AAGGGAAAAG AGGCCGTACA AGTCATCTAT AATCTAAACC TTGCTAGTGC AAAAGTGATT 300

CAACTATATC GCTCATTAGG ACTTGATGGA AAGATTGGGA TTATTTTAAA CTTGACACCT 360

GCTTATCCAA GAAGTAATTC TCCAGAAGAC TTAGAAGCAA GTCGATTTAC AGATGACTTC 420

TTTAACAAAG TCTTCCTTGA ATCCAGCTGT TAAAGGAACT TTCCCAGAAA AGATTGGTAA 480

AAACAGCTAG AGAGAGATGG CGTGTTATGG AGTCATACCG AAAAAGAG 528

(2) INFORMATION FOR SEQ ID NO:148:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 778 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 148:

ACTCTTATTG GTGAGGTATC GCAACTTCTG TTTCTGCCTT CCTTGGTGGA CCAGCCAATA 60

CAACTTACGG AGAAAATACA GGGGTTATCG GTATGACTCG TATCGCTTCT GTCTCAGTTA 120

TCCGTAACGC TGCCTTCATC GCGATTGCCC TCAGCTTCCT TGGTAAATTC ACTGCCTTGA 180

TTTCAACTAT TCCAAACGCT GTACTTGGTG GTATGTCAAT CCTTCTCTAT GGGGTTATCG 240

CCAGCAATGG TTTGAAAGTC TTGATTAAAG AACGTGTGGA TTTCGCTCAA ATGCGAAACC 300

TCATCATCGC AAGTGCTATG TTGGTTCTTG GACTTGGGAG GAGCTATCCT TAAACTTGGT 360

CCAGTTACAC TTTCAGGTAC TGCCCTTTCA GCCATGACAG GAATCATCTT GAACTTGATC 420

TTGCCATACG AAAATAAAGA CTAAGAGTCT AAATACACCT AATCCACTCA GACAGCTGAG 480

TGGATTTTTC GTATACCATA ATAAAAGTGT CTTAACAAAA TTATTAAAAT CAAAAAACGT 540

ATAATATCAG ATATTCTAAA ACCTTGATAC TGTACGTTTT ATCATAGAAA TTTTTACTTT 600

ATTTTCTCAT CAAATGAGAT TTGCATCAAT CTCTTGTCTT ACTTGCGTTT CTTCTTCGCT 660

TTCTTCATTT TGTTAGCCAT ACGTTTCATG GACTGTTTCA TGGCAAATTC ACCAATTTTA 720

CCTTTCAAAC CGCCACCAAA CATCTGGCTC ATATCTGGCA TTCCTGCTCC TCCGAGAG 778

(2) INFORMATION FOR SEQ ID NO: 149:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 622 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 149:

GGGAGTTGGT TGCTATTNGT GAGGGAAAAG GTTTGAACTT TGAAATCGAA GTGGATGGTG 60

GGATTGATGA CCAAACTATT GCTCAAGCCA AAGAAGCTGG TGCGACTGTT TTTGTAGCAG 120

GTTCCTATGT CTTTAAGGGA GAAGTCAATG AGCGAGTACA AACTCTCAGA AAACAACTGG 180

ACTAGGGTTG CAGTTTTTGC AGGCGGAAAC CGCGGTCATT ATCGGACAGA TTTTGATGCT 240

TTTGTTGGGG TGGATCGAGG CTCGCTCTGG GTCTTGGAAG AAGACTTACC TCTTGCTCTA 300

GCAGTCGGAG ATTTTGATTC TGTGACGGAA GAAGAGCGAC AGGTGATTCA AAAACGTGCC 360

CAGTATTTTG TCCAAGCCCG GCCAGAAAAA GATGATACTG ATTTGGAATT GGCTCTCTTA 420

ACCATCTTTG AACAAAATCC TCAGGCTGAG GTCACTATTT TCGGTGCCTT GGGTGGCCGT 480

ATTGACCATA TGTTGGCCAA TGTTCTTTCT ACCTAGCAAT CCCTAAGTTG GCACCCTATA 540

TGCGTTCNAA TAGAAATTGA GGAATGGGCA AATTTGATTG CCTATTGTTC CAGAAGGGAA 600

CAGTCAGATT CGAATCCCTG CA 622

(2) INFORMATION FOR SEQ ID NO:150:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 497 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 150:

CTATTATCAG CACTTTTATA CCTATTACCA AAAAAATCCT CAAAATGATT GGCAAAAGGC 60

TTTATCCACC AGCCATTTAT CAGCAATATT TACTTGAAAA ATATGGTAGA AATAGAAAGG 120

ATGGAGGAAT CTAATGGTAT TACAAAGAAA TGAAATAAAT GAAAAAGATA CATGGGATCT 180

ATCAACGATC TACCCAACTG ACCAGGCTTG GGAAGAAGCC TTAAAAGATT TAACAGAACA 240

ATTGGAGACA GTAGCCCAGT ATGAAGGCCA TCTCTTGGAT AGTGCGGATA ACCTACTAGT 300

AAATCACTGA ATTTTCTCTT GAAATGGAAC GCCAGATGGA GAAGCTTTAC GTTTATGCTC 360

ATATGAAGAA TGACCAGGAT ACACGTGTAA GCTAAGTATC AAGAGTACTA TGCCAAGGCC 420

ATGACACTCC TACAGCCAGT TAGACCAAGC CTTTTCATTC TATGATCCTG AATTTATGGA 480

TATTAGCGAA AAGCAGT 497

(2) INFORMATION FOR SEQ ID NO: 151:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 605 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:151:

CTGTTATGGA GTTGAAAGAA GAATACCACC CAGACGGTAA AGGTTTTGAA ATGATCTGTA 60

TCGGTGGGAT GGGAGCTGAT TTCTTTAAGG CTCGCGGTAT TCAACCACTT TATGAATTAC 120

GTGGCTTGTC AGACCAACCT AGCTTTGATC AAGTTCGTAA GATTATTTCA AAAACTGTTG 180

AAATGTACCA AAATGAACTC TTTGATGAGC TTTATGTTTG CTACAACCAC CATGTCAATA 240

CGCTAACCAG TCNAATGCGT GTGGAACAAA TGCTTCCGAT TGTTGACTTG GATCCAAATG 300

AAGCGGATGA AGANTACAGC TTGACTTTTG AAATTGGGAA ACCAGCCGAG AAGAAATTCT 360

GGAGCAGTTG TTGCCTCAGT TTGCAGAAAG TATGATTTAC GGTGCCATTA TCGATGCCAA 420

GACAGCTGAG AATGCTGCGG GTATGACAGC CATGCAAACA GCGACAGATA ATGCTAAGAA 480

AGTCATCAAT GATTTGACAA TTCAGTATAA CCGTGCCCAG ACAGGCGGAT ATTACACAAG 540

AAATTACCGA AATCGTAGCA GTGCCTAATG CCTTAGAATA GCTCTAGTCC CAGCTCTCCT 600

CACTC 605

(2) INFORMATION FOR SEQ ID NO: 152:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 517 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:152:

CTACACTTGA GGGAAGTTTG AAAATTCCAT TTTTCTTAAA GGGAATTGTG AAACGCTATG 60

TATTTTCTTT TTACAACCGG ATGGAGCACT TGGTTGTGGT CAATCCTATG TTTATTGAGG 120

ATTTGGTAGC AGCTGGTATT CCACGTGAAA AAGTGACCTA TATTCCTAAC TTTGTCAACA 180

AGGGAAAAAT GGCATCCTCT ACCACAAGAA GAGGTAGTCA GACTGCGCAC AGATCTTGGT 240

CTTAGTGACA ATCAGTTTAT CGTAGTAGGT GCTGGGCAAG TTCAGAAACG TAAAGGGATT 300

GATGACTTTA TCCGTCTGGC TGAGGAATTG CCTCAGATTA CCTTTATCTG GGCTGGTGGC 360

TTCTCTTTTG GTGGTATGAC AGATGGTTAT GAACACTATA AGAAAATTAT GGAAAATCCC 420

CCTAAAAATT TGATTTTTCC AGGCATTGTA TCGCCAGAGC GGATGCGCGA AATTGTATGC 480

TCTAACGGAT CTTTTCTTGT TGCCTAATTA CAATGAG 517

(2) INFORMATION FOR SEQ ID NO:153:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 798 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153:

TGTTCGCCTC CATATCCNAA ACTTGCCCTG CCACCATACC CAGACTACCT GAAGCAAGGG 60

ATAAGTTGGC AATCGAGCCC ACCTNGATCT GACTTGGCGA ATCTGCCTGC GCAATCAAGG 120

CATATGGGTC TAAGAATAAG GATCTCCAGC CAAAATGGCC ATAGCTTCAC CGAATTTCTN 180

GTGATTGGTT AACCGCCCTC TTCGATAATC GTCATCATCC ATAGCAGGAA GGTCATCGTG 240

AATCAAGCTC CCTGTATGAA TCATCTCCAA GGCAGTAGCT ACCTGCGCGN GAGCAGGTTT 300

GATGGTAACC TGCAAGGCTT CCAGAACTTC TAACAAGAGA AAAGGCCGAA TACGCTTGCC 360

ACCAGCATGA ATAGAATAGA GAACAGACTC CCGTAAACTA GAGGCAAACT GCTGGTCTCC 420

ATAAAATCTT CCAAAGCCGA CTCGACAAGA GCTAATTTTT CTTGCTTTTT CATTCAAAAT 480

CACTTTCTGT TCCGTCTTCT TGCATGACCT TGACCAAGGT CTTTTCAGCC TTGTCCAGCG 540

TAGCTTGGAG CTCTTTTGAC AAGACCATGC CCTTTTGAAA GGCAGTAATC GCATCTTCCA 600

GAGCAATTTC ACCATTTTCC AAACTTTGGA CAATGGTTTC CAGTTCTGCT AGATTTTCCT 660

CAAATTTCTT TTGTTTTGAC ATCTTTAACC TCTAATTCTA CTTGACCATC TCGCATCAAA 720

AGCGTTACTT GGTCTTTTTT CTTCAAACTC TCAACCGAAT CTACAACGGA TCTTCTTTTT 780

TGACAATAGC ATAACCAC 798

(2) INFORMATION FOR SEQ ID NO:154:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 547 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 154:

CCATGTTTGC GGCAGTGACA GCAGGTTATC AGGCTGCCCT AATGGTACCA ACAGAAATCC 60

TCGCAGAGCA ACACTTTGAG AGTTTACAGA ACCTTTTTCC CAATTTGAAA CTGGCTCTCT 120

TGACAGGTTC CTTGAAAGCT GCAGAAAAGA GAGAAGTCTT GGAGACCATT GCCAAGGGTG 180

AGGCTGATTT GATTATAGGA ACTCACGCTC TGATACAAGA TGGGGTGGAG TATGCTCGTC 240

TTGGTTTGAT TATTATCGAT GAGCAGCACC GTTTTGGTGT AGGGCAAAGG CGTATTTTAC 300

GGGAAAAAGG CGACAATCCA GATGTCCTCA TGATGACGGC GACTCCCATT CCACGGACGC 360

TTGCCATCAC AGCCTTTGGA GATATGGATG TTTCCATTAT CGACCAGATG CCAGCAGGTC 420

GGAAGCCCTA TTGTGACGCG CTGGATCAAA CATGAGCAAC TACCTCAGGT CTTGACTTGG 480

TTAGAGGGGG AAATTCAAAA AGGTTCCCAA GTCTATGTCA TCTCTCCTTT GATTGAAGAA 540 TCAGAAG 547

(2) INFORMATION FOR SEQ ID NO:155:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 536 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 155:

CTCTTTTAAC CGTTTTAGCG GTGACACCGA GGTATTTTTT CAGGACCCAA GACTTGTCGG 60

GCAACCGAAA CTGGGAGTTC GTCATCTCCA ATATGCAGAC CAGCAGCATC AACCGCAAGA 120

CAAACATCCA ACCGATCATC GATTATCAAG GGGACCTGAT AGGCATCTGT TATTTCCTTG 180

ACTTGTTTTG CCAGTTGATA ATATTGATTG GTTGTGAGAT TTTTTTCTCG CAATTGGACT 240

ATGGTAACCC CTGAACGGCA GGCCGTCTCA ACTTTTGCAA GAAAGCTTTC CACGGAATCT 300

TGATAGCGAT TGGTTACCAG ATATAGTCTA AGCGCTTCTC TATTCATAAA CCTCTCCTTT 360

GATGGTATCT AGCCAATTTT CATCTCTTCT TAGGAGCGAA AGCTGATTGA GTACTTGGTA 420

ACGAAATTCT TCCAATCCCA TTCCTTGAAC AACTATTTTC TCAGCCAGCG ATATTGAGAT 480

AAGAGACTGC TAAGCAAGAA CTTCAAAACC AGTCTTTCCT TGGCTGAGAA AAACAG 536

(2) INFORMATION FOR SEQ ID NO: 156:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 854 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:156:

CTGGAGTGAC GATTGAGAAA ATCTTTGCCC TAGAAAATTA TCGAAATCAG TTAGCTGCTT 60

TTCCGCAAAC TGTCTGGATT TCAGAGGATA TTTTGCTAGA TTTGGCGGAT TCTCAGACTC 120

CACAGGGAAT TGTTGCCGTG GTTCAAAAAG AAGAAGTAGG ACAAGCTGAT TTGAGTCAGG 180

GCAAGTTCTT GTTTTTGGAA GATGTGCAAG ATCCTGGTAA TGTAGGAACT ATCATTCGAA 240

CTGCGGATGC AGCAGGTTTT ACAGGAGTGA TTGTTTCAGA TAAGTCGGCA GACATCTACA 300

GTCTTCAAAA CCCTACGTTC CATGCAAGGT AGTCATTTCC ATCTGCCCAT TTACCGGATG 360

ACTAGTCAAG CGCTTCTTGA CGAAACTAAA AAGGTAGCTA TCCCAGTGCT AGCAACAACC 420

CAATCTAAAG ATTCTGTTGA TTACAGAGAA CTGCCTTCTA TAGAAAATTT TGTACTAGTT 480 ATGGGAAATG AGGGTCAAGG AATTAGTCCC CTTATGGCTG AAAGTGCAGA CCAGTTGGTC 540

CATATTAGCA TGAAGGGGCA GGCCGAGAGT TTGAATGTTG CGGTTGCAGC CGGTATTTTA 600

ATCTTCCATT TAAGCTAATT TTAACT TTT TTGTTATAAT CAAGGAAAGA TGTTCACAGA 660

AAAGGAGAAA TGGATGAATC ACACTATTAT ACATGACCGT GCAGGTCTCA ATCAATTTTA 720

CGCTAAGGTT TATGCCTTTG TTGGTCTGGG AATCGGACTA TCTGCTTTGG TATCAGGCCT 780

TATGTTGACG GTCTTTCAGT CTCAGTTGGT TTACTTTTTG ATGCAGGGGC GTCTCTGGTT 840

GACCATTGCT ACTT 854

(2) INFORMATION FOR SEQ ID NO: 157:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 636 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 157:

CTGAAGAAAT CCTAAAAGAT TTGTATTACG GAGCCGCTAA GAAAATTCAA GAAGAAGCCT 60

CTCGCTGGGC AGGAGTTGTA AGAAATGACT AAAACAGCCT TTTTATTTGC TGGTCAAGGT 120

GCCCAGTATC TACGGATGGG ACGGGATTTC TATGATCAGT ATCCGATTGT CAAAGAAACG 180

ATTGATCGAG CGAGTCAGGT GCTCGGTTAT GATTTACGTT ATCTCATCGA TACGGAAGAA 2 0

GACAAACTCA ATCAGACCCG CTATACGCAA CCAGCCATTC TAGCGACTTC GGTTGCTATC 300

TACCGTTTAT TGCAAGAAAA GGGCTATCAC CCTGATATGG TTGCTGGTTT GTCTCTTGGA 360

GAATACTCTG CCTTGGTGGC AAGCGGCGCC TTGGATTTTG AAGATGCCGT TGCCTTGGTA 420

GCTAAGCGTG GAGCCTATAT GGAAGAAGCG GCTCCTGCTG ACTCTGGCAA GATGGTAGCA 480

GTTCTCCATA CCCCGTAGAG TCCTTGAGAA GCCTGTCCAA AGCTCTGACT TGAGTGGTAC 540

TCCAGCCACT ATACACACTG CACAATCTCA TTGCTGGAAA ATTGTTGCAG TGATCAACGG 600

TGACTTTGCA GAGCAGTGCC AACCCTATCC CCTAGT 636

(2) INFORMATION FOR SEQ ID NO: 158:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 693 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 158: CTCTAAAACG AATTCTCTAC AAGCACCGCA AGGGCATGGC TGAACTTCCA CCATAAGGTG 60

GTTTGTCTCG AAAGGCTAAT ACTTCNTTAA CCTTAGTTTG TCCTGAAAAT TGGTACATAT 120

TGAAGAGGGC CGCCCGTTCT GCGCAGAGAT GGAAAACACC ACAGGTTCCC TCCATACAGA 180

ATCCTGTAAA TATTTGTCCA TCTCCTGCTT CTACTGCAGC TACAACATGA TTGGCATAAA 240

CAAAGTCTGA TACTTCATGT GGATTGTATA GTTTCTGTGC TTCTTCCTAC ATCTTTTCCC 300

AGATGTCCAT TATTGTATCC TCTATATTTA GAGATTTCTT TTAGAATGTT TTCGATATGC 360

TGAATTGATT TTTCACGTCC AAGCAAGAAA ATTGTATCTG GTAATTCTGG CCCATGCATT 420

TCGCCTGAAA CTGCGATACG AATAGGCATG AAAAGATTTT TCCCTTTAAT ACCTGTTTCT 480

TTTTGGACTG CTTTAATTTG CGGGAAGATA TTTTCTGTCA CAAATTCATC ATCTGTCATC 540

CGCTTCAATT TTTGCTTTGA ATGCTTCAAG AACTGTTGGA ACTGTTTCAC CCGTCATGAC 600

TTCGCGCTCT GCTTCTGTCA ATTCCTGGGA AATCTGAGAA GAAAGATCTG TCCATGGGAT 660

ATCTCATCTA CTGATTCATT GTGGTTTATA GAG 693

(2) INFORMATION FOR SEQ ID NO:159:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 553 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 159:

CTGACAAAGG AGACGGGTAT GGAACAAACA TTCTTTATCA TCAAACCAGA TGGTGTAAAA 60

AGAGGGCTAG TGGGTGAAGT GTTAAAGCGC ATCGAACAAC GTGGATTTAC AATCGAAAAA 120

TTGGAGTTTC GTTCACAGGT TTTCAGAAGA GTAGATTGAC CAGCACTATC AGGACCTGGT 180

TGGTCAGAGT TTTTACCCAC CGATTCGTGA ATTCATGACT TCAGGTCCAG TTCTTGTGGG 240

TGTCATTTCT GGTCCCAAAG TAATCGAAAC TTGGCGGACC ATGATGGGTG CAACTCGTCC 300

AGAAGAAGCT TTACCAGGCA CTATTCGAGG TGATTTTGCA AAAGCTGCTG GAGAAAATGA 360

GATTATCCAA AATGTTGTAC ATGGTTCAGA TTCCGAGAAG AATCAGCTAA GCCGAGAAAT 420

TGCTCCTTTG GTTTTAAGAG TGGATTGGCT CAATCAATTG GATAAAAGCT CATTTGAATA 480

GAAAGTATAG TCAATTAGTT TAAGAςATGA CGCATGATAT CAAACTTTTT AGTTTTTGAT 540

ATGGTGCGTT TTT 553

(2) INFORMATION FOR SEQ ID NO: 160:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 488 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:160:

CTAGAGATTT NCGAAGAGTA TTATTGTACT TTAAAGGTCT TGAGATAATT GTCTTTNCCT 60

ACTTGACCTT CGAAGGTTTT ACCATTTTCA AGGTAAGGAA GGTCATCGGA TACTGAAGCC 120

TTGACCTTGT ATATCTTGCC ATCAACTTTA AAGAAGTAGA CAGTGTCTCC CTTGATAACA 180

GCTGATTTGA GGTCTGCTAC TACTCCCTTG ATGCTTTCTG TCGTTGCATT GTCAATTTCA 240

AGGTCGTTTT TATTGGCATA CTTGCTGAGC ATCTCTTCCA CTGTAGTAGC AACGATAACA 300

TTTTGGTACT CGACTGCGTC TACCAGGGCG TACTCTTTGA CCAAGCCAGC ATTGTCCTTT 360

AAGCCCATGA TGTAAAGAGG CTTGTCATTG AGGTTGATAA AGATTGGGGA AAGGTTGCTT 420

TGTAGGATTT CTCCTGAACA GCACCTTCTG CTGATTCACG GGCTGATTCT TCTGTCGCAG 480

AAGCCAAG 488

(2) INFORMATION FOR SEQ ID NO:161:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 543 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:161:

TACAGCTATC GGGTCCGTCT GGTAGTTGGT CCTCAGAACC TTCACTGCCA CTTCTTCCCC 60

ATCTAAGATT AAGTCTTTGG CTAGGTAGAC ATCCGCCATG CCTCCTCGAC CAATCTGTTT 120

GACAATCCGA TAGCGTCCGG CAAAAATCTT GCCGATTTGG ATCATTCTTC ATCCTCCTCG 180

TTCATAGAAA CAAGGGCAAC CGTAATGTTG TCTAAACCTC CTGCATTGTT AGCAAAACGA 240

ACAAGTGTCT CCGTTTTATC TGCTAAAGGA ATATCACTGG TTACAATATC ACGAATCTCA 300

CTGCCTGAAA TCATGTTGGT CAAGCCGTCA CTATTGAGCA AGAGATAGTC ACCTGACTCA 360

AGGATAACTG TCCCAAAATC AGGCTGAATT TCATCTTTTT GCCCAATAGA CTGGGTGATA 420

ATATTTTTTT GTGGATGACT TCTGCCTCTT CTGGTGTCAA TTGACCAGCC TTGAGCAATT 480

CATTAACCAA AGAATGATCG CTCGTCAACT GATGGTATCT TCTCCACGAA TCAAGCCGAT 540

ACG 543

(2) INFORMATION FOR SEQ ID NO:162:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 504 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:162:

CTTTAAGGAA AATCAAATCT CTCATGCTGA TACCTCTCCT CATTAAATTA AATAGTAAAA 60

AAGATTCTAT CTCACTCCCT GATTATTACA AAACCATTGA AATATCACAA CTAATAGGCT 120

AGAATGGACA TAGTAAGATN TAGTAGATGA GTCATTCTAC TCAAATCCAC GTTAGAAAGG 180

ACTGCTATGC CAGACAATCT CGCGCTTCGC ATGCGCCCTA AAACCATCGA CCAGGTCATC 240

GGTCAGGAGC NTCTGGTCGG ACCTGGAAAA ATCATCCGCC GCATGGTGGA AGCCAACCGC 300

CTGTCCTCCA TGATTCTATA TGGCCCTCCT GGAATCGGCA AAACCAGTAT TGCCTCTGCC 360

ATCGCTGGAA CGACCAAGTA TGCCTTTCGA ACTTTCAATG CGACAGTTGA TAGTTAAAAA 420

GCGACTGCAA GAAATCTCGG AAGAAGCTAA ATTTNCTGGT GGTCTCGTCC TATTGCTAGA 480

CGANATTCAT CGACTAGATA GACC 504

(2) INFORMATION FOR SEQ ID NO:163:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:163:

CTAATAGAGG CGAAAAAATT TCAGGTCCTC CTTTGCTAGA TGATAATGAG GAAACTAAGA 60

TTTTACCAAC CTCTTCTTCC CGTTTTGGTT ATGCCAATCC TAAGGATCAT GGTTTTAGCC 120

AGGAAACCTT GAAGATTCAG GTCGAACCAT CTATTCATAA AAGCCGTCGT ATTGAAAATA 180

CCAAGAGAAA TGTCTTCAAT TCTAAGTTGA ATAAAATCTT ATTTGCGGTC ATCTTTCTCT 240

TGATTTTGCT TGTTTTAGCA ATGAAACTTT TGTAATAGAA AAGGAATTGA AATGAAAATA 300

GGAATTATTG CTGCTATGCC AGAAGAACTG GCTTATCTGG TCCAGCATTT AGATAATGCC 360

CAGGAGCAAG TTGTTTTGGG GAATACCTAT CATACAGGAA ACCATTGCTT CTCATGAAAG 420

TCGTTCTTGT TAAAAAGTGG AATTGGTAAG GTCATGTCTG CTATGAATTG TGTGGCGAAT 480

TTTGGCTGAT CATTTCCAGG TTGGATGCCC TTATTAATAC GGGTTCAG 528

(2) INFORMATION FOR SEQ ID NO:164:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 472 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:164:

CTAATAAGAC TGAAAAGAAG TCCAGCCAGA TGTCCCTAAA AATACAGAAA AAACATTAAA 60

ACCAAAGGAA ATCAAATTTA ATTCTTGGGA AGAATTGTTA AAATGGGAAC CAGGTGCTCG 120

TGAAGATGAT GCTATTAACC GCGGATCTGT TGTCCTCGCT TCACGTCGGA CGGTCATTTA 180

GTCAATGAAA AAGCTAGCAA GGAAGCAAAA GTTCAAGCCT TATCAAACAC CAATTCTAAA 240

GCAAAAGACC ATGCTTCTGT TGGTGGAGAA GAGTTCAAGG CCTATGCTTT TGACTATTGG 300

CAATATCTAG ATTCAATGGT CTTCTGGGAA GGTCTCGTAC CAACTCCTGA CGTTATTGAT 360

GCAGGTCACG TAACGGGGTT CCTGTATACG GTACACTCTT CTTCAACTGG TCTAATAGTA 420

TTGCAGATCA AGAAAGATTT GCTGAAGCTT TGAAGCAAGA CGCAGATGGT AG 472

(2) INFORMATION FOR SEQ ID NO:165:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 605 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 165:

CTTTTAAATA AGAAGAATCA CACTCATTGC TAAATGTGAT ATAATATTGT TCTCAGTCTC 60

AGCAGTGCGT TGTGAAAAAG CCATACTAAT CCCTGATTTT TCCGCATATT CCATCACCTC 120

AAGTGTTTTA CTCACTGAGC CAACTTGATT AGGCTTTATT ACAATACCAT CAGCACAATC 180

TTTAAACTGT GAAATTCTTT CTAAGTTTGT TGCGTAAAAA TCATCACCAA AAACTTGTAA 240

CTTTAGAGGT TTTATCAATT GAAATTTTCT CCAACTATCC AAATCTTCAT CGGAAAATGG 300

ATCTTCAAGA TAAACCAATG GATACTTAAC TCCCCAATCA CAATAAGTAT CCATAATTTC 360

TGTGACTGTC TGTTGCTGAC TAACACACCA TGGTACTTTA TATATGCCAA GTGAAGAATC 420

GTAACGATCT GTCATTGCTA AATCTAAACC GATATCATAT CTATTTTTGT ATAATTTTAA 480

TGTCTCTAAT AACGAATCCA AAATAATATA AAAATCATCC GTGTTAATTA TTAATGCACC 540

TTGATAGAAA TAGATGTTGT AGAAACCTGG GTTTTAACTT TATCATAACT CATTTTTATG 600

TTAGA 605

(2) INFORMATION FOR SEQ ID NO: 166:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 552 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:166:

CTGAAGAAAA TCAGTAAACA AGAGCTGGTT AACACGCGCT TTTCTCGTTT ATTTGCTCAT 60

TTTGGACAGG AAAAAGACGG TAGTTTTCTT GCCCAGCGTT ACCAATTTTA CCTCGCCCAG 120

CAGGGACAAA CACTATCGGG CGCTCATGAT CTCTTGGACA GCCTCATTGA GCGTGATTAT 180

AACTTGTATG CTGCGACAAA TGGCATTACT GCCATTCAGA CAGGACGTTT GGCTCAATCT 240

GGTCTAGCAC CTTATTTCAA TCAAGTCTTT ATCTCAGAAC AGTTGCAAAC TCAAAAGCCG 300

GATGCTCTTT TTTATGAAAA GATTGGCCAG CAAATTGCTG GATTTAGTAA AGAAAAGACC 360

TGATGATTGG AGATTCTCTA ACCGCCGACA TTCAAGGTGG CAATAATGCG GGGATTGACA 420

CTATCTGGTA TAATCCTCAT CACCTCGAAA ATCACACACA AGCCCAGCCG ACTTACGAAG 480

TCTATTCTTA CCAAGACTTG CTGGATTGTT TAGATAAAAA TATTCTTGAA AGATCACGTT 540

TTAAGGAGAT AG 552

(2) INFORMATION FOR SEQ ID NO:167:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 405 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:167:

CTTTGTCTGT ATCTGCCTTT TTATGCTATA CTTAAGGTAT GCATAGAAAA ACAGTGATTG 60

ATTNTAGGAC TTTAGGGGAG AGATATACCT TTACCCANCC TATTAAAGAG TTGAAAACGA 120

GAAATGTAGC AGAAGTGGCA GATTTGCTGG CACNAGTGGA AAGCTACCAA GAGCAAGATT 180

ATTATGTGGT GGGGTATGTC AGCTACGAGG CTGCACCTGC TTTTGAGGAG AAATTAGCAG 240

TTCACAAGGT TCCTCTACTG GGCGAGTACT TGCTT ACTT TACTGTTCAC GATAGGGTGG 300

AGACCTCCCC TATTCCTCTG ACTTATGAGG ATATTGATTT GCCCTCAAAT TGGCAGGGAA 360

NTAACGTCTG CACAGAACTA TGANAAGGCC ATTGCCCAGA TACAC 405

(2) INFORMATION FOR SEQ ID NO:168:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 524 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:168:

CTCAAAAACA GCTTCTAACA GCTTGAACAA GGGGGCTAAA ATTGATTCCT TGATGTAGGG 60

TTTGAAGTAA GATAATAGGT GTTTCATAAA TCCCTTCTAT TCATATTCTA GAAATGAAGA 120

AAGTGGGAAG CCCCACTCTC TGTTTTATTT GTTTAAGTAA GGCAATAGAT AGCCATATCC 180

TGCTTTTTCC ATCTCATCCT TGGCCACAAA GCGTAAAGAA GCAGAATTGA TACAGTAACG 240

GAGGCCGCCT AACTCCCGCG GTCCATCTGT GAAAACATGA CCCAAGTGAG CACTGCCTGA 300

ACGAGAACGA ACTTCAATTC GCTCCATTCC ATGGCTCAGA TCCTTGTAAT AATGAATCAA 360

CTCTTTGGAA ATCGGACGGC TTAAAACTTG GCCAACCCAC AACCTGAAGC AAACTTATCC 420

TTGGCAAAAA AGAGTTGGCT CACCTGTTCG TAATATCTAC ATAAATCCCC TCCTTCCAAA 480

GGTTTTGGTC CATAGGCATT GGTAAATGGA CCTCCTGTTA CCAG 524

(2) INFORMATION FOR SEQ ID NO:169:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 593 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:169:

CTTCATCTGG TGGTTCTCCA GTTGTAAGTA ACGTAGTACC ATTCTCAAAA CCATACTCAC 60

AAGTTGGTAT TAAGGGGGAA CCATATATCT TTAAAGGAAT GAAATTGCAA AAAGATATTG 120

TTACAACAAA AGAATATAAC GAGGTTTTAA AAAATGGCAA AAAGAAAAAT TGGAATCCAA 180

TAGCAAATAC CAAAAAGAAC TAGAAAAATA CATTAAATAA GGAATGG AT TGATCTTGAT 240

AAAATTTTTA AAATACTGTC ATTTTGAATA TAAAGGAGTT TGATATGGAG TGGATTAGAT 300

TAATAGGAAT AGCAATCATT GTTGTGGGTT TTATTTTAAA ATTTGATACA ATTGCAACAG 360

TAGTCTTAGC TGGTTTGGTT ACAGCTTTAG TTTCAGGTGT TTCTCTCGTT GAATTTTTGG 420

AGATTTTGGG AAAAGAATTT AGCAATCAGC GAGTGCTCAC GATTTTTATG GTTACCTTGC 480

CTCTTGTGGG GCTGTCAGAA ACCTTTGGAC TCAACAACGA TCAATCGATT TGATTCGAAA 540

GATTAAAGGT CTGACAGTTG GAAACTTCTA TACAGTTTAT TCTTTATCGA GAG 593

(2) INFORMATION FOR SEQ ID NO: 170:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 456 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 170:

CCTGCTCCTT ATCTTTGCAG TAATTGGCGT TTTAGTGGCC TTGATAGCTC AATTTTACTC 60

AGCAAAGGCA GCAGTAGGTT TTGCTAAGGA ATTGACAAAC GATCTTTATC GTCATATTCT 120

TTCCTTGCCC AAGGACAGCA GAGACCGTCT GACAACTTCT AGTTTGGTTA CTCGCTTGAC 180

TTCGGATACC TACCAGATTC AGACTGGTAT CAATCAATTC CTGCGTCTCT TTTTACGAGC 240

GCCCATTATC GTTTTTGGTG CCATTTTTAT GGCTTATCGA ATCTCAGCTG AGTTGACTTT 300

CTGGTTCTTA GTCATGGTTG CCATTTTGAC CATTGTCATT GT AGGGTTA TCTCGATTGG 360

TCAATCCTCT CTACAGTAGT CTCAGAAAGA AAACCGAACC ACTGGGTTCA NGAAACCCCC 420

CNCCATTGCA AGGATGCCGG GTTATTCCGT GCCTTT 456

(2) INFORMATION FOR SEQ ID NO: 171:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 565 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:171:

CTTGTACAGT TGAATCGTTC AGATATTGAT TTTGAAAACA GAGAGTGTGT TGTCTTTGGT 60

AAAGGAAAGA AGGAGAGACC AGTATATTTT GACGCTCGGA CGAAAATTCA TTTAAGAAAT 120

TATCTTAACG ACAGAAAAAG ATAGTCACCC TGCTCTTTTT GTAACGCTAG TTGGAAAAGC 180

CCAGAGACTT GGAATTGCTG GTGTAGAGAT TCGCTTAAGA AAGTTAGGAG ACAAACTCGG 240

CATACAAAAG GTTCACCCAC ATAAGTTCAG AAGAACTTTA GCGACTAAGG CAATTGATAA 300

AGGTATGCCT ATCGAACAAG TCCAAAAACT GCTAGGTCAT AGCAAGATTG ACACAACCCT 360

GGCCTATGCC ATGGTCAATC AAAATAATGT CAAGCATTCA CACCAAAAAT TCATCTCTTA 420

AAAGCAAATC CCGATATTCC GAAGAGGTGG TTGCATGAAG AAAGTGAAAT TAGGTGAAGT 480

GGCTACTTTT ATCAATGGCT ATGCTTTTAA ACCTCAAGAT TGGTCCTCTG AAGGAAAGAG 540

ATTATCCGAA TTACCGAATC TGACT 565

(2) INFORMATION FOR SEQ ID NO: 172:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 538 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 172:

CTTTATACTT TATCATTTCT AACTTAATTA TAGTCTTATT TTTAATAAAG TTCAATTATT 60

TATATG AAA ATTCCTCATC AGTAAAAAAT AACCGATCTC ATTTCTGAGA ATCGGTTTTC 120

TAAATAAATC AAACCGATCA TTTACATAAC ATAAATTATG TAAATGATCA TACTACAACA 180

ACAAATCTTT GACTTTTCCA ATTTCACTTT TTGGAATAAC CAGGTGAATC ATATCACCCA 240

GATACATTCT GGTTGAGCCG TTAACTGTTT GGCTCTTGCC ATTATGGACT TGAGTTGTGA 300

TGAGGACGTT GTGTGGTAAG TTGAGTTCAT GAACTTGTTT CCCAGCAATT TTATCAGAAA 360

CTGGTATTTC GATAAGTGTA ACTTCTCCTT CGCTAGATAC TTCTTCTGGG AAGCATTTTT 420

TCCAGCATGG CTTCATAGAC TGGCGTTCCT TTGAGCNAAT CCCTGATNAT TTTAGAAACC 480

AGAGTGACAG ACCAGTGGCT TAAGGTGCGA ATATCTCCTA CCATCTCAGT TACGAGAT 538

(2) INFORMATION FOR SEQ ID NO: 173:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 509 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:173:

CGTGCTAACC ATGAGAGCAT ATATTTCCTC CAACTATTTC TATTTCAAAA AATCCTTACT 60

ATATTGTATC ACAATCAGAC ACAAAAAGAA AAAGCAAATG ATAAACAAAT GCTTTTAANG 120

TTTTAAAAAA AGCTTCGAAA GGTTCTTCTT TATTTTTTAA NGGGAGAGAT AACGTTGATA 180

TCTAAATCGT GGTCAAAGCC GGCAATTTTC CTTTAGATGT GTATTGGTGA ATATCATAAT 240

CTAAATCAGT TTTAGGACTG CTCTCCAAAA ATCCTGAGTC TGAGCCGTAG GACGGAATCC 300

AAACAGAGGT AAACTTGCCT GTATCAATAC TGTGTTCTTC CATGAAGTAG ACACCAACGT 360

AGATGCCGAT GTTTTTAGCA CCTAGTGATG CTAGTTTTGC TCGAAAGTTT TCGACACCTT 420

CGTTCATATA GACATAGTTT TGTCTCCACG TCAGCCCATA GTAACTAGGC TGTTAGGAGA 480

GCACATTGTA GAAAACTTCG GCAGCCTTT 509

(2) INFORMATION FOR SEQ ID NO: 174:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 572 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:174:

CTGTTCTGTT TGCGACGCTA CTTGGTTGTA GCATGGGGGT GGTTTTAGAT GGTCAGTAAG 60

TATCTTTTAT TAGCAGTTAT TTTCTCTGGC TTGGTGACTT GGATTCTCCG TATGATTTCC 120

TTCATCTTAG TCAAGTATAA GGGCTTGCCT GCAATCGTTG AGCGTTTTTT GAAGTTCTTG 180

CCCGTTTCCA TTATCTTTGC CTTGATTCTT TCAAGCGTAG TGACAGGTAA GGTTGGGAGC 240

CTTCCTCAAA TTAAATGGCT AGACTTCTTA GCCGTCTTTC CAACAGCTTG GGTAGCCTTT 300

CGCTACCGCA ATCTACTCGG AACAGTTCTC TTTGGAGTGG TCTTGATTGC CATCTTGCGT 360

TTGGTCTCTT AAATTACCCA CCAAAAAAAC TTATCACAGA GATAGATATC ATATAATGGC 420

GTAAATGCTC CTTTTCTGTT AAGATTATAA GGTATTCTAT TTTGGAGGAA ATGACATGAA 480

AAAAATCGTT AAATACTCAT CTCTTGCTGC CCTAGGACTT GTTGCTGCAG TGTGCTTGCG 540

GCTTGCTCAG GGGTGCTCAG AAAGAAGAGA AC 572

(2) INFORMATION FOR SEQ ID NO: 175:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 497 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 175:

CTAGGTTATT TAGTAAAAGA CTAGAAGATT TTCTTTTCCC AATCGTCTTC TGTACGGCGA 60

GGATAGAAAA ACTCTGACTT GTCGGGAGCT TCCATCATTT CCATCAATGG TAGCATATCA 120

TAGGCCAGAT TTAAGTTTGG AATCTGGTCT TTTTGCACCC AAGAAACTTC TCCCTCTTCT 180

GAAGATTGAA GGGTACCAGA GAACTCAGTC GCCTTATAAC AAATGACAAT ATAGCGCCCA 240

CCTGTATCTA GTGGCCAATT TTTAATGCCG ACAAGTTGAG GATTTTGGAT AGTCAACCCT 300

GTTTCTTCGT AGATTTCACG AATGACAGAC TCCGCAAAAG CCTCATCATT TTCTACATGA 360

CCTCCAGGAA AGGCATAACC AGACCAGCGA TTGTTTTCAG GGGCGCGATA CTGCATCACC 420

ACGCGCTGAG TTTCGANGTC TTCCATCAGA CAGATATTTG TTTAAATTGT TTAATTGGGA 480

ACGGGACATA AATTTAC 497

(2) INFORMATION FOR SEQ ID NO: 176:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 425 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 176:

CTGAAATTTT GGAAGAAGAA ATCGGTGTAG ATACAGTCCA AAAAATAGGA CGCATCTTGA 60

TTTTGTTTAA ACAATCTAGC AAGAAAGAAA ATCGCAAGAT TTCTAAGAAA GTCAAAGAAA 120

TCTAAGATCG AAACTCCAAA TAACTGTTTT TATAGAGAAA TAAAGGGGAC TAGCCTATGA 180

CAATCGAACT ATTGACTCCC TTTACCAAGG TAGAGTTGGA GCCAGAAATC AAGGAGAAAA 240

AACGCAAACA AGTTGGGATT TTAGGGGGGA ATTTTAACCC TGTTCACAAT GCCCATCTCA 300

TTGTTGCGGA TCAAGTACGG CAACAGTTGG GACTGGATCA AGTTCTGCTC ATGCCTGAAT 360

ACCAACCTCC TCACGTTTGA TAAAAAGGAA ACCATCCCTG AACACCATCG TCTCAAGATG 420

CTTGA 425

(2) INFORMATION FOR SEQ ID NO: 177:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 418 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 177:

CTGCTATCAA GACAGTATTA CCGCTGAAAG AAACAGCTTC ACTAGAAGGC GCAATTGAAA 60

AATAAGACGG GATCACGAAC TCCCGTTTTT CTATAAAAGA AAGGAAATGG GATGAAAAAA 120

TTAGTCTTTG TCTGTCTGGG AAATATTTGC CGTAGCCCTA TGGCCGAGTT TGTTATGAAA 180

TCAATGACAG ATAACTACGA AATCCAAAGT CGAGCAACTT CCTCTTGGGA ACATGGCAAT 240

CCGATTCATA AGGGGACTCA GGGAATTTTT CAAGAGTATG AGATTCCTTA TGACAAGAAC 300

AAGACATCGC TTCAGATTAG TAAGGAAGAT TTTGAAGCCT TTGATTATAT TATCGGAATG 360

GACGCTTCAA ATGTTCCGAC TTACGTCAGA TGTGTCCAGT AGACTGTCAA GATAAGAT 418

(2) INFORMATION FOR SEQ ID NO: 178:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 387 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:178:

ACTGTTTGAA AAATATGATT CGTGGTCGAG AAATGAATTG CATTTAAGCA ATGTAGTTCA 60

GTATATAGAT TTGGAAATTA ATGATTTAAC AAAATAAAGG AGAAAAAACA TGGTTAAATA 120

CGGTGTTGTT GGAGCAGGGT ATTTTGGAGC TGAATTGGCT CGCTATATGC AAAAGAATGA 180

TGGAGCAGAN ATTACTCTTC TCTATGATCC AGATAATGCA GAGGCGATTG CAGAAGAATT 240

GGGAGCAAAA GTTAGCAAGT TCCTTAGATG AGTTGGTTTC TAGCGATGAA GTTAGATTGT 300

GTTATCGTCG CAACTCCCAA ATAATCTTCA TAAGGAACCG GTTATTAAGG CTGCACAGCA 360

TGGTAAAAAT GTTTTCCTGT TGAAAAA 387

(2) INFORMATION FOR SEQ ID NO:179:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 561 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 179:

CTTATGAAAT CAATCATCAA AATAATATTG ATCAGGACTA TTTAGGTAAA TTATCTACAA 60

CGATTAAATT GGTAGCAGAA AAGGAAAATG CCGTTGAGAT CCTAGAACAC TTGAATGTTG 120

TCCCTGTGTT GACAGCCCAT CCAACACAAG TGCAACGCAA AAGTATGTTG GATTTAACAA 180

ATCATATTCA TAGTCTTTTG CGTAAATACC GTGATGTTAA GTTGGGGTTA ATCAATAAAG 240

ATAAATGGCA CAATGATTTG CGTCGTTACA TCGAAATT T CATGCAGACA GACATGATTC 300

GTGAGAAAAA ATTAAAAGTG ACTAACGAAA TCACGAATGC TATGGAAATA TTACAACAGC 360

TCCTTTTTGA AAGCTGTCCC TCATTTGACG ACGGAGTATA AGCGCTTAGC GCAAGCGCAT 420

GGTCTGAATT TAAAACAGGC TAAACCAATC ACCATGGGTA TGTGGATAGG TGGTGACCGT 480

GAAGGAAATC CATTTGTTAC AGCAAAGAAC TTGAAGCAGT CTGCACTCAC TCAGTGTGAA 540

GTCNTCCTGA ACTTACTATG A 561

(2) INFORMATION FOR SEQ ID NO:180:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 496 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 180:

CGACCTAATC ATATTGATAC TGCATTTGCA TCAGCAGATT TGTTTGAGTA TAAATTACAA 60

TTAGCAGGAC AGACTTGGGG ATATTTAGAA TTTGAAACAA ATACAGAAAA ATATGGGAAA 120

GTATTGTTAA TTATAAAGGG TAAGAAGCGA CTTACGAACC AATTTCCTTT GGTACAAAAA 180

AATAAGAGTG GCTACTTATT TGAATATGCT CAGATGAATA CACTTTATCT TAATCAACAT 240

TCTTCCTACA AAAATGATGA AGATAGTCAT TCCTTTCCAA TTCAGATGGA GTTAGTTTCT 300

GATGAAATGA TTCCAAGAAA TTGAACAAGC TACTAAAAAT TCCGAATATC CGAAAAATTT 360

ATGATTTTAA CTTATGANGC GGACTCCCGA AAAACAATAT TATATCTGTT AGATGTTTGT 420

TATGCCCTGA TGCCCGAACT GGTCCAGTTA CACTTGATTC CAGATTGTCC TGAGTATATC 480

CATCCAGTTC CGTACC 496

(2) INFORMATION FOR SEQ ID NO: 181:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 504 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 181:

CCACCCTCTA GCAAGTGGTG CTAATTCCTA TAGCCTAGAA GAAAACGAAA TCATCTACCA 60

AAAGTTAAAA AACTTGCTTA AAAACTGATA AAATACTTGC CAAACTTTTC AGAATCTGAT 120

AGACTAGTAT GGTAACAATC TATGGCTCGC AAAGAGACCA TGGCAGAAAG GAAATATTGC 180

AAAATGAAAA AAGATATCCA TCCAGAATAT CGCCCAGTTG TCTTCATGGA CACAACTACT 240

GGTTACCAAT TCCTTAGCGG TTCAACAAAA CGCTCTAACG AAACAGTTGA GTTCGAAGGC 300

GAAACTTACC CATTGATCCG TGTGGAAATT TCATCAGACT CACACCCATT CTACACTGGA 360

CGTCAAAAGT TCACTCAAGC AGATGGACGC GTGGATCGTT TCAACAAAAA ATACGGTCTC 420

AAATAATGAT AAGAGAACAG TTTCGGCTGT TCTTTTTTGT TTCTTGAAAT CAACTGCTGT 480

TTTCATGTTC CAGACTCATC TGTA 504

(2) INFORMATION FOR SEQ ID NO: 182:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 470 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182:

CTCAGGCGAT TACTAATTAC ATGACTTCTG CCTCAAACTT TAATGTCGAT GAGGCTAGCC 60

AATTCATTCA ACAATTTACA AT ACAAAAC AAATCGAACA AGTAGAAAAA CTATTAGAGG 120

AGTAGCATGG AAACTGCATT AATTAGTGTG ATTGTGCCAG TCTATAATGT GGCGCAGTAC 180

CTAGAAAAAT CGATAGCTTC CATTCAGAAG CAGACCTATC AAAATCTGGA AATTATTCTT 240

GTTGATGATG GTGCAACAGA TGAAAGTGGT CGCTTGTGTG ATTCAATCGC TGAACAAGAT 300

GACAGGGTGT CAGTGCTTCA TAAAAAGAAC GAAGGATTGT CGCAAGCACG AAATGATGGG 360

ATGAAGCCAG GCTCACGGGG ATTATCTGAT TTTTATTGAC TCAGATGATT A ATCCATCC 420

AGAAATGATT CAGAGCTTAT ATGAGCAATT AGTTCAAGAA GATGCCGATG 470

(2) INFORMATION FOR SEQ ID NO: 183:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 526 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 183:

CT ATACTTG CTTTTTTCCT TTTGAAAAAT GTTAATAAAT CGTTGGTAGT CTTCTCTAGG 60

CATGGACAGA TCAATATCGT CGTCCCAAGG GATAAAGCCC TCATGTCGAA CCGCCCCAAT 120

CAGAGTACCG TAGTTAATAA TATAGTTGAT ATTGTGCTTT TTACAGAGAG TATCAATATA 180

ATCCAAAATT TCTAATTCAA TTTGTTTGGC ATCTTCAATG GTTAGTTGTT TCATTTTAAA 240

CTCCTATGAT TTTTTGAATT TATTTTTTAA GGCTAGGACA TGGTTTAAAA ATTCATAGAA 300

AATGCTATCT TTTGTGAAGA CAAGTAGACT AATATAAGAG ATAGCTGATA ACAAGACAAT 360

CAAACCAGTA TTAATCAAAA ATGGCAAATT AATGACCATA TCCACAGGAT ACACGAAATT 420

AATCAGGAAA TACATTGCTA CAAAGGAAAG TGAAAAGAGA GAGTATCGAA CAGTATAGCT 480

AAAGATATGT CCCAAGTGGA TGAGTTGTTT CTATGGATGA AATGAT 526

(2) INFORMATION FOR SEQ ID NO: 184:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 433 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA O 97/37026 PCI7US97/05306

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:184:

ACCATATCAA TACTATCGAA AAGTACAAGG GATNCAGTCT CAAGGTCGCT GAGGAAGATT 60

TGAATGACCT AGACGATGGT GAATTTTACT ATCACGAGAT TATCGGTTTG GAAGTCTATG 120

AGGGTGATAG CTTGGTTGGA ACCATCAAGG AAAATCCTGC AACCAGGTGC TAATGATGTC 180

TGGGTGGTCA AACGAAAAGG CAAACGTGAT TTGCTTTTAC CTTATATCCC ACCAGTGGTT 240

CTCAATGTTG ATATTCCAAA TAAACGGGTC GATGTGGAAA TCTTAGAAGG GTTAGACGAT 300

GAAGATTGAT ATTTTAACCC TCTTTCCAGA GATGTTTTCT CCACTGGAGC ACTCAATCGT 360

TGGAAAGGCT CGAGAAAAAG GGCTCTTTGG ATATCCCAGT TNTCATAATT TTTCGAANAA 420

AATGCTGAAA AGG 433

(2) INFORMATION FOR SEQ ID NO: 185:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 540 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 185:

CTGCAACTTG AATTTCTCCT TCTTGTTTCA AAGCAAGATA AACAATTCGA GCCCCTCTTT 60

TTTCTAGCAA ATCCCCCATC TGGACAGATT GCATAAAGGA ACGAGAAGAA ACCTGATCAG 120

AATAAGTCTG AAACTCTTCT TTCGTGAGTG TTGTTAGTGC CATATACTTA CTTTCTATGT 180

TTTTTTCTTA ATGTTT ACG GAAATCAAGA GCAAGTCTTA ACAGAGGATA GAGAGGATGA 240

GTGGGCATTG TAAATTCACC CAAGTATTCT TCAATCGTTG GATTAAATTT TTCCTTAAAA 300

TGATAAAGTC CACCATTGAG AGAGTTTTCA ACACCACCTA AATTTTGCCA GACCATACCT 360

CGCTCAAAGG CATAGCGAGC CGTTTCATAC CATGTTAAAA TTGGTGCATT GTAACGTTTA 420

AAATCATCAT CCATACCAGC ATATATATTG ACAGAGGTAG TACCAAATTC CAAACTCAAA 480

GTACCGCTAA AGGAATCTCG CTTGACCTAC ATCTATA AT TCCTGCAAGA AGGTCAATTC 540

(2) INFORMATION FOR SEQ ID NO: 186:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 186: CTCAGGCTAA AAGAGTCCAC TGGACTCTTT TACTCCGTCC CATAACCAAT GACTTAATGG 60

CGCGTTCAGC TAGATTATTG GAAAGGACCA GATGTCCGTC TTTCAAAATA GTCTTAAAGG 120

TTTCTTCATA CTTGAGGCTG TATTCAATTG CCCTTCCTAG TTTTGAACCC GATAAAACTG 180

ACTGACGCCG GCACCAAGCA AAGAAATCTT CCATTAGGGG TTGGAGCTCT TCTTGACGTT 240

TCTGTAGTCG TTCATCAGCT GACAATGTCT CCCAGTCTCT TTCCAAGGCA AATAACTGAT 300

CACAATAGGC TAATCCTTTA G 321

(2) INFORMATION FOR SEQ ID NO:187:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 415 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 187:

CTTGACCAAA CAAGGCAGTT GGAAATTGAT TTTGGAGGAT GAGAGCGCTG GAAGGGAACT 60

CTTCCCAATC TTGACTCAAG GTCNATATAT CGCAACATTT GACCAACAAG CGCCANCTAT 120

CGATGAAATC TTTAAACTAT AATCAGGAGT GGAAGTATGA GAAATATGTG GGTTGTAATC 180

AAGGAAACCT ATCTTCNACA TGTCGAGTCA TGGAGTTTCT TCTTTATGGT GATTTCGCCG 240

TTCCTCTTTT TAGGAATCTC TGTAGGAATT GGGCATCTCC AAGGTTCTTC TATGACTAAA 300

AATAATAAAG TGGCANTACT GACAACAGTG CCATCTGTAN CATAAGGACT GAAGAATGTA 360

AATGGTGTTA ACTTCGACTA TAAAGATGAA GCAAGTGCCA CCAGAAGCAA TTAAA 415

(2) INFORMATION FOR SEQ ID NO:188:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 246 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 188:

CTATNAAATA GAGTGGTTCT CTATCTGCCA TGACCACAAA TNAGGACAAT GATACTTCTG 60

AACGTTCAGA CTGCTATCGT AAAAGGACAG CGGGTGAGAC GCCCATGAAT GATCTAACCA 120

GTCATACCCA CGGAGGAAAT TATACAATAG CACGTTATCA GGAGGAAAAA TTTTGGAACA 180

AACAGTTGTA AAATATAGTC TGCAGTTATC AATGCTTAAT TTTTTACAGG CGAAGATAAT 240 CGAACG 246

(2) INFORMATION FOR SEQ ID NO:189:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 189:

CTTGTCATCC TCACGAAAAT TGCGATTGTA AAGCACCAAG CCTTGACTCG TGATAGACTG 60

AATCATGCTT CTCTCATGTA CTCCTCAAGT CGTTTCATGG CTTCTTTGAT AGTCTCCATG 120

CTGGCTGCAT AAGATAGGCG GACGTAGCCT TCCCCGTAAC GTCCAAAGGC TGCACCAGGG 180

ATAAAGGCAA CGGCCTTCTT CTGAGCAAAA TCCTTCAGAA AAGCAAAGGA GTCTTGATTG 240

TAGCCCGCTG GAATTTTAGC AAAAATATAG AAGGCACCGT CTGGTTTGAT AATCTCAAAA 300

CCAAGAGCAG TCATTTTTTC GATGATATAG TCCCGACGTT GGATATATTC CTTCTTCATG 360

GGCTCCGCAT CGTTTTTACC AGCCGTCAAG GCTTCTACCG CAGCATGTTG CGCCATGGTA 420

TTTGCGGCAG TGACCAAGTT ACTGGTGACT CTTGATTAAC TGGGCTGTGA AGGTCNCANG 480

AGCAAAAATC AGCCCCAAAC GCCAACCTGT CATGGCATG 519

(2) INFORMATION FOR SEQ ID NO:190:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 468 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:190:

CTTCAGCTAT TCGTGGGATA TTAGATGTAC TTATTTAGGG GTTGAAATCA TATGAATATT 60

ACCAATTTGT TTTCTATCAA GACAGGATGT GATGAAACTG ATAGGCAACT GCAAAAACTA 120

TTTTTTCAGT TGGATTTACA ATTGGGAGAA TTGACAGATC AACTAAGAAA ATTAGATTCT 180

AATTTTGTTC CTCGTAGTCA ATTTGTAGAC ACGTTGGATT TGAATGATGT AGAATATAAA 240

GAAATTTTAA ACTATTTTAT CTTCCATCGT AATGATAGTG AAGAAAGTTT GGTAGAATGG 300

TTATATGATT GGATTTCCAC AAATCGTTAT GAACTTCCCT AAAGAGTTTT CCGATTCCGT 360

ATGGCTCCAT AAATACCCAT GAAAGTGTTA CTGAAGTTTT CCGGAGAATG AATAACTAAA 420

AAACAGTCAT TAGTGACTGT TTTTTATAGA AAAGAGTTTT TATATGTT 468 (2 ) INFORMATION FOR SEQ ID NO : 191 :

(i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 545 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 191:

CTTGAATAGT CTCATCACGA AAATTGCCAT AACTGATAAA ACCAACCACC TTCACGCCAT 60

CCATCGCAAT CAATGTATTT TCTGGATACT TTTGACTAAA GAATCGACAT CTTTCTAATG 120

TCATTG ATC CTGAAATTCC GCAGGCAAAA GGTCATCATA AGACTCTCTC CACGTTTGCC 180

AGTGAACGAG GGATTTGCCT TCTATCTCTT CAGGAGTTNC CATAGATTTG ATAATAACCG 240

TCATTTATTT TCTCCCAGTC TNCTCTCAAA ATACCATATT TAATACTATC AAAATATTTA 300

CCTTGATAAT AACGAACTTT NGGAATATGA GCTNCTTTTT TCATNCTTAA TTTTTCAGCA 360

AGTTTCATCA TACCAAGATT TCCTGACCAA GTTGTCAAAA CCAGATGCTC CAACTCCAAG 420

TAATCCTGAA ACGTCCTATC TATCCACTGC AACATAGCAA CTTTCCCAAT ACCAGTGTTC 480

CAGAATTTTT TATCATAAAT ACCAATTCCC AATCCATCCA TCTTGTTTCC TTTACATACC 540

CAATA 545

(2) INFORMATION FOR SEQ ID NO:192:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 517 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 192:

CTTGATTGTG GAAGAAGTCC GTGATCGCTA TGTGGGCAAA GTCGATGCCG TTTTTCATAA 60

CGGCGATTCT GAACTACGTC CGGATTCTCC ACTTTGGGAG GGCATCCGCG TTGTTAAAGG 120

GAACATGGAC TTCTACGCCG GCTACCCAGA ACGTCTGGTG ACTGAGCTTG GTTCGACCAA 180

GATTATCCAA ACTCATGGTC ACTTGTTTGA CATCAATTTC AACTTTCAAA AGTTGGACTA 240

CTGGGCTCAG GAGGAAGAGG CCGCTATCTG CCTCTATGGT CACTTGCATG TGCCAAGTGC 300

TTGGTTGGAA GGCAAGATCC TCTTTCTAAA TCCAGGCTCT ATCAGTCAAC CACGAGGTAC 360

CATCAGAGAA TGTCTCTATG CTCGTGTGGA GATTGATGAT AGTTACTTCA AAGTGGACTT 420

TTTGACACGA GATCACGAAG TGTATCCAGG TTGTCCAAGG AGTTTAGCCG ATGATGCCAA 480 GGAGTTGAGA CTTTCTGTTG GGGCAGAGAA CTTTTGA 517

(2) INFORMATION FOR SEQ ID NO:193:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 458 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:193:

CGTAACCATT AACTATGAGG TGGTTTGCCT CCTCAGCGAC CGTATTCCGA GAGAATATTA 60

TTAGAAAAGA AAGGAGTGGA GCATGAATCT ACATCAACCC TTGCATGTCT TGCCTGGTGT 120

GGGACCAAAG TCAGCAGAAA AATACGCCAA ACTAGGAATT GAAAACTTGC AAGATCTCTT 180

GCTCTACTTT CCTTTCCGTT ATGAAGACTT CAAAACCAAG CAGGTGCTGG AACTAGAAGA 240

CGGTGAGAAG GCAGTTCTTT CTGGTCAGGT AGTGACTCCT GCTAGTGTCC AGTATTATGG 300

TTTCCAAGCC GCCAATCCGC CTGCGTTTTT AGTCCTCCAA GCCAGGGAAG AAGGTTCGTT 360

TTTTTTTGGC GGGTGAAATT TCCTTTTTAA CCCAGCCCCC TATCCTTGGG CTTGAATAAA 420

AAATTAGAAA TTTTGGGGAA CCAACCCCTT TGGCTTGT 458

(2) INFORMATION FOR SEQ ID NO: 194:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 566 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

( i) SEQUENCE DESCRIPTION: SEQ ID NO: 194:

CCTTACTAGT TTACTCAATC TTTACATCGT TCTTTCGGCA GTTCAAACTC AGAATCCACA 60

GCACAGGTTA TGCAATTACT GTCTGAAAAT ATGTTAAAAA CCATTCAGTC ACTTTCGGTC 120

TGGCAGATTT ATTTGCTTGG TTTTGAGCGA ATCTTGGCGC TTGGTTTCCA ATTACTTTTG 180

ACAGTTTGGG TTTACCAAGC TGTTCGCCAG AAGAAATGGA TTTATCTCCT AGCAGCCTAT 240

GGCTTGCATG CCTTCTTTGA TCTGGCACCA TCTCTTTTCC AAGTAGGCTG GTTGACAAAT 300

CCAGTCTTGG TTGAAGTGAT TCTAGCACTG GAGCTCGTTC TGGTCGCCTA TGGAACCAAG 360

GAAATCTTTT GTAAAAAATC ATAAAAAGGG GGGAACCTCT TTTTCTTATG CAAAATCCAA 420

ACAAGGTATT TTTATGGTCG TCAAATGTCT CTAAAAATGG TATAATGGAA TGAATTTTGT 480

AAAAGGAAGA ATGACATGTC TGTAAGAGAA AAAATGCTTG AAATCTTAGA AGGAATTGAT 540 ATCCGTTTTA AGGAACCCTT GCATAG 566

(2) INFORMATION FOR SEQ ID NO:195:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 523 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:195:

CTTTGACAAA GAGTATGACA CCTGACCGTG AAGTCATTAC CTTTATTCCT GAAAAATTTA 60

TTGTGGATGG TTTCCAAGGG ATTCGTGACC CACGTGGCAT GATGGGGGTT CGCCTTGAAA 120

TGCGTGGTTT GCTTTATACA GGACCTCGTA CTATCTTGCA CAATTTGCGT AAGACGGTTG 180

AGCGTGCAGG TGTTCAGGTT GAAAATGTTA TCATTTCACC ACTAGCAATG GTTCAGTCTG 240

TTTTGAACGA AGGGGAACGT GAATTTGGTG CTACAGTGAT TGATATGGGG GCAGGTCAAA 300

CGACTGTCGC TACAATCCGT AATCAAGAAC TCCAGTTCAC ACATATTCTC CAAGAAGTGG 360

AGATTATGTA ACTAAAGATA TCTCCAAGGT TTTGAAAACC TCTCGCAAAT TAGCGGAAGG 420

CTTGAAACTG AATTACGGGG AACCTATCCG CCTCTTGCAA GCAAAAAACT CCATTAAAGT 480

TATTGGAGAA TTAAACCAGT CAAAGTGACG GAACCTACTT GTC 523

(2) INFORMATION FOR SEQ ID NO:196:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 538 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:196:

CTGTGATTTC AGAGAAGAAA TCAAGTGCTG TAACAGAAGT AAGATGTAAT TGTATGTAAA 60

GGAGACGTCA TGTTAAATAG TATTGTAACC ATTATTTGTA TTGCCCTTAT CGCGTTTATC 120

TTGTTTTGGT TTTTCAAAAA GCCTGAAAAA TCTGGACAAA AAGCCCAGCA AAAAAACGGA 180

TACCAAGAGA TTCGAGTGGA AGTCATGGGA GGCTATACTC CTGAGTTGAT TGTCCTCAAG 240

AAATCAGTGC CAGCCCGCAT TGTCTTTGAC CGCAAGGATC CTTCACCATG TCTGGATCAA 300

ATTGTTTTTC CAGATTTTGG TGTACATGCG AACCTGCCAA TGGGGGAAGA GTATGTAGTG 360

GAAATCACGC CTGAACAGGC TGGAGAGTTT GGCTTTGCTT GTGGTATGAA CATGATGCAC 420

GGCAAGATGA TTGTAGAGTA GGTGGAGACT ATGACAGAAA TTGTGAAAGC AAGCTTAGAA 480 AATGGCATTC AAAAAATCCG TATCCGAGCT GAAAAAGGCT ATCATCCACC CATATCCA 538

(2) INFORMATION FOR SEQ ID NO:197:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 515 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 197:

CCTCAAGAAG TCCGCGATAC TTACGAAAAT ATTTTGTAGA GAATCGAACC GCAAGGTTCG 60

GTTTTCTTTC TCTTTTTGTC TATAATTTGG TATAATAAAC AGTATGAAAA TCGTATCAGG 120

AATCTATGGG GGACGTCCCC TCAAGACACT AGAAGGCAAG ACAACAAGAC CTACTTCGGA 180

TAAGGTTAGG GGAGCCATTT TTAACATGAT TGGTCCCTAC TTTGAAGTGG GACNAGTCTT 240

GGACCTTTAT GCAGGTAGTG GTGGTTTATC TATCGAAGCA GTATCGCGTG GCATGTCCAG 300

TGCTGTTTTG GTGGAGCGAG ACCGTAAGGC TCAGACCATC GTGGCTGAAA ATATCCAGAT 360

GACCAAGGAA GTTGGAAAAT TTCAACTCCT CCAAAATGGA TGCAGAAAGG GCATTGGAAC 420

AGGTTNTCTG GGGAATTTGA CCTCGTTTTC TTAGACCCTC CCTATGCCAA GGAACAAATC 480

GTAGCAGATA TTGAAAAAAT GGCTGAGAGA GAGCT 515

(2) INFORMATION FOR SEQ ID NO: 198:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 342 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:198:

CTGGANACAA ACTTTACAGA TCAAGTCGAT ACGATGATTT ATGTTGATAA AGAAGAAAAA 60

GAAACTATTA AAGCTGCACT TGTGGAGTTT TTTAATGGAA AAGTCACTTT AACTGACCAA 120

GGTTTACGAG AGGTTGAAGT TCCTGTAAAC TTAGTGTAAA CAATGAATAA TACAGCGTTT 180

CGTTGACATT CTCACAACTA CTTTAGCGAG CAAAATAAAA AGATGCGTAC CAAAATATAC 240

TAGAAAATGA AGCAATTCAA ACGAAACCTG ATATCGTTTT CCTTCACACC TATTTACTAG 300

AATTAACTGA ACGCAATCAC TTGAAAATTA ATGACTTTGG AT 342

(2) INFORMATION FOR SEQ ID NO: 199: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 418 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 199:

CTATTAGCGA CTTTCTCTGA AATATGGTAT GATAAAGGAT ATACAAGGAG ATAAAATGAA 60

TAATAATTTA CTGGTATTAC AATCCAGACT TTGGTCTGGT TGATGGTGCG GTATCGGCTA 120

TGATTGGAGT GGCTTTAGAA GAGTCTCCAA CCTTAAAAAT CCATCACTTG ACGCACGATA 180

TCACGCCTTA TAATATTTTT GAGGGGAGCT ATCGTCTCTT TCAGACGGTG GATTACTGGC 240

CTGAGGGAAC GACGTTTGTA TCGGTTGTCG ATCCAGGTGT CGGTTCGAAA CGTAAGAGTG 300

TAGTTGCCAA GACTGCTCAA AAATCAATAC ATTGTCACGC CAGATAATGG GACGCTTTCC 360

TTTATCAAGA AACACGTTGG CNTTGTANCC ATTCGTGAGA TTTCTGAGGT GGCCAACT 418

(2) INFORMATION FOR SEQ ID NO:200:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 463 baεe pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:200:

CTCTCGCTTT TCTCATAGTG GGAGGTAAGG ATGGAATTAC GCAGACCAAG ATTAGCGGAT 60

AAGAAAGCTG TTTTAGATAT GATGACAGAG TTTGAAAAGA GCC ATCAGC CCATGATGGA 120

GGATTTTGGG ATACAGAGAA TTTTGTGTAT GAAGAGTGGT TGGAAAGCAA TCAGGAACAG 180

GAAATGGGGA TTAATCTGCC TGAAGGATGG GTTCCTGCAA TTCAGTTAGT GGCTTTTTCT 240

GAGAAAGGTC AAGCAGTTGG ATTTCTTAAT CTCCGGTTGC GCCTCAGTAA CTTTCTACTA 300

GAAGAAGGTG GGCACATTGG CTACTCCATC CGTCCATCTG AAAGAGGCAA GGGTTATGCA 360

AAAGAACTCT CCGTCAGGGC TTGCAAGTTG CTAAGGAAAA GAACATCAAG AAAGCTCTGG 420

TGACCTGTAG CGTGAATAAT CCTGCTAGCA GAGCATCATT CTA 463

(2) INFORMATION FOR SEQ ID NO:201:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 475 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:201:

CTCTTACGTG ACCAGAACAT GCTACTTCCC ATCCGAGAAG CCATTCTATC TGGCTTACCA 60

GTGTTTGGGA CCTGTGCGGG CTTAATTTTG CTGGCTAAGG AAATCACTTC TCACAAAGAG 120

AGTTATCTAG GAACTATGGA TATGGTGGTC GAGCGTAATG CTTATGGGCG CCAATTANGA 180

AGTTCTNCAC GGAAGCNNAA TGTAAGGGAG TTGGCNAGAT TCCNATGACC TTTATCCGTG 240

GTCCGATTAT CAGTACTGTT GGTGAGGGTG TANAAATTCT AGCAACAGTG AACNATCAAT 300

TTGTTGCNNC CCAAGANNAA AATATGTTGG TAAGTCCTTT TCATCCAGAA TTGACTGATN 360

ATNTGCGCTT GCNCCAGTAC TTTATCAGTA TGTGTAAAGA AAAAAGTNGA GATTGAATTT 420

CTCCAACTTT NCCACNTGTA ATNNNCAATN NCNATGTATT GGAGTACGGA CGCAG 475

(2) INFORMATION FOR SEQ ID NO:202:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 451 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:202:

CCTTCAAAAA TTATTTGATG CAACCTTAGA CAATCCAGAA CTCACCGCAA CATTAGTGCC 60

TTTAGGAGAT GGTATTCTCA TGCTTCGTAA AAATGTAGCA GATGTTCAAC TGTCTGAAAG 120

CGAATGATTT TCAGAAAAAT TTAAGAAAAA ATAGTAAAAT AGATAGAGTA ACACTTATCT 180

CAAAGGAGTA GACATGAAGA AAAAATTATT GGCAGGTGCC ATCACACTAT TATCAG AGC 240

AACTTTAGCA GCTTGTTCGA AAGGGTCAGA AGGAGCAGAC CTTATCAGCA TGAAAGGGGA 300

TGTCATCACA GAACATCAAT TTTATGAGCA AGTGAAAAAC AACCCTTCAG CCCAGCNAGT 60

CTTGTTAAAT ATGACCATCC AAAAAGTTTT TGAAAAAACA ATATGGCTCA GAGCTTGATG 420

ATAAAGAGGT TGATGATACT ATTGCCGAAG A 451

(2) INFORMATION FOR SEQ ID NO:203:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 453 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:203:

CTATGGATAA GGCACTTGCT GACCTCAAAA CATCAGGGCA CTTGCCTATT CCGCGACACC 60

TACGTGATGG GCACTACANT GGAAGCAAGG AACTGGGGAA TGCCCAAGAC TATCTCTATC 120

CACACAACTA TCCTGNAAAT TGGGTCAAGC AAGACTATCT GCCACAAAAA ATTCGTAATC 180

ATCACTATTT CCAAGCAGAA TATACTGGTA AATATGAACG GGCTTTGGCT CAAAGAAAGG 240

AAGCTATCGA CCATTTGCGA AAAATCTGAA ATCCTTTTCA AAAAATTGCA CTTTCCTCTT 300

GATTTTTTTT GAAAAAGTGG TATCATATAA ATATAGAAAC GCTGTGGTGT ACGACTTCAC 360

ACTTAAGTGT TGACCGACTA TTTTTTGTAT TATTANGGAA ACAAAAGTCT TCTGTCAGCA 420

TGTAGGCCGT CTCACACGGA AACAGCTTCA GTT 453

(2) INFORMATION FOR SEQ ID NO:204:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 432 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:204:

CCGTAGTACA GGCACAAAAA GATTTGGAAA ATAGAAAAAG AAAAGCCAAG AAAAAGGCTC 60

AGAAAACGAA ATAAATAAGG AGGAATCTGG TAATGGTAGT ATTTACAGGT TCAACTGTTG 120

AAGAAGCAAT CCAGAAAGGA TTGAAAGAAT TAGATATTCC AAGAATGAAG GCTCATATCA 180

AAGTCATTTC TAGGGAGAAA AAAGGCTTTC TTGGTCTATT TGGTAAAAAA CCAGCCCAAG 240

TGGATATTGA AGCGATTAGT GAAACGACTG TTGTCAAAGC AAATCAACAG GTAGTAAAAG 300

GCGTTCCGAA AAAAATCAAT GATTTGAACG AGCCTGTGAA GACGGTTAGT GTAAGAAACC 360

GTTGACCTTG GTCATGTGGT TGATGCTATT AAAAAAATAG AGGAAGAAGG TCAAGGTATT 420

TCTGATGAAG TC 432

(2) INFORMATION FOR SEQ ID NO:205:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 428 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:205:

AAAATCAAGA AATTCTTTGA AGGAACGACA GATACAGCTG AGAACTATAT CAAGTCGGCC 60

CTTAAAATGT TGGTCAAATA GGAGCAGAGA ATGACAAAAC GTTGTTCGTG GGTCAAGATG 120

ACCAACCCGC TCTACATCGC CTATCATGAT GAGGAGTGGG GTCAGCCCCT CCATGATGAC 180

CAAGCATTGT TTGAGTTGTT GTGTATGGAA ACCTATCAGG CAGGCCTGTC TTGGGAAACG 240

GTACTCAACA AACGCCAAGC TTTCCGAGAA GCCTTTCCAT AGCTATCAAA TTCACTCCAG 300

TCGCAGAGAT GACTGACACT GAATTGGAAG CCATGCCTGG AGAATCCCAG CTATCATTCC 360

GAAATAGAGC CCAAGATTTT TGCTACACGC CGCCTAACGC CCCAACCCTT TCCTACAGTT 420

ACAGGCAG 428

(2) INFORMATION FOR SEQ ID NO:206:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 518 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 206:

CTATTAGATG GTATTGACTG CCCAGACACT TACGGATCTA GCTGAGACAG GGAATTGTCC 60

ATAACCTTCC TCATCAATTG TAACTTGACC TTGGTGGTTA CCAAGTAAAT CTACAAAGGT 120

TTGATTAGTC CATTCTTGAC CGACAAACAT TGACTTGCTG TTTTCTTGGT CATTTGAAAT 180

CAAGACTGCG ATTGGGGATT GATTTTCAGC ACCTGAACGT ACCCAACCGA TACAGTTAGC 240

ATGGTCAAAG TAGTCATTTT GTTCTCCATA GGCCAAATCT TTTCGGATGG CTAGGAGGCG 300

GTCAAGGATT TCTTTGAAAT CTTGTTGAGC ATACTGGCCT GAAATCCCAT AGTAGTCTCC 360

GTAAAAGACA CATGGAAGGC CGTCTTGGCG TAACAAAATG AGGGCATAGG CTGCTGGCTT 420

GAACCATTCT TCAACGGTAG ACTCAAGGGC TTGTCCTCGT TGGGTATCGT GGTTGTCGAC 480

AAAATCACAG ACTTGTCAGG CTTGAGTTCA ACCAGGCT 518

(2) INFORMATION FOR SEQ ID NO: 207:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 508 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207:

CTCTGTCCTT TTACCTGAGA GTTTGAGCAG TTGCCTGCCT TGCCCCTTCG GTGCCTTTAC 60

GGTCTCTCCA GAGTTCCGTC CATTTACAGT CATGGAAAAT CAAACGATTC CCCACTTCTA 120

TTAAACTTCA TTCGGTGTTG GTATTTAATT GATTCTAATT TTACAAAAAA TGTTGGCTTT 180

TGTCAATGTG TTTATTAGTA AAAATTAGTT CAACAGTTTT TACTTTATAA AGTCCAGAAT 240

ACTGCTATCC TTTAAAAGTG ACAATAGTCG CACCACTGCC TCCAGCATTT TGTGGGGCAT 300

AGCCGAAACT CTTGACATGT TTGTTTCTTT GCAAGTATTT GGTAACTCCT TCACGGATGA 360

CTCCTGTTCC GATACCATGG ATGATATCAA CTTGAGCCAT ATTGTTAAGC AAGGCTTGGT 420

CGAATGAAGG TATCTAGCTC ATTCATGGCT TCTTCATAGC GCTTGCCTCG AAGATTCAGT 480

CTAGCTTGAG TCCTCGCCCA GAAGTTCG 508

(2) INFORMATION FOR SEQ ID NO:208:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 378 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 208:

CTCTTGGGCT CTCTTCTCAG CAACTTCCCT GCTTTCACCT TTGGTCTTGA TAGGTGANAA 60

CGTAATATNT CCAATCNNNG TCATATTAGG AAANAGTTAA ATTGTTGGAA AACCATGCCC 120

ATCTTCTCAC GCATGGGAAA CAGGTCATTC TTCTTGTCCG TAATATCGAC TCCCTCAAAG 180

ATAACCTTCC CCTTGGTTGC TTCCTCCAAC AAATTCATAT AGCGAAGCAA GGTAGATTTC 240

CCACTCCCTG AAGGACCGAT GATAACGACA ACTTCTCCTC TTTTAATCTC GAGGTTGATG 300

CCCTTCAATA CTTCATTCTT TCCAAAAGAT TTATGTAATT TTCAATTTTT ATCAAGGTTT 360

CTGTCATTAT TTCTTATC 378

(2) INFORMATION FOR SEQ ID NO:209:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 741 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:209: CTGGCCAGCC AGATAAACCT CGATACGGCT TTCTGCTCGT TTGATGCGTT GCAAGAGTCC 60

GCCCATACGG ACGTCAACTG TATCCAAACC AAAGACCTTG TTTTATTTCA GCCAGTGGTG 120

ACTAAAGAGG GCATGGAAGT CTTCAATTTG GCTTCTAAGT TCTGGTAATT CTTGTCTGGC 180

GATTTGTTGT AAACTTTCTT TATCATCCGC TTGGTAGGCA TGACGAATGC GTCGTCCCAC 240

ATCTACTTTG CTACTTAAAA TAGCATTCAA CTGGGCCTGA GTTTCAAAGA GATAAGCATA 300

GTTTCCAGCT TTTTCTTTAA TGTCAGCAAT AGTTCCCGCC GCCTGAGCGA AGTGTGGCTT 360

GTCCTGTTCA GGTGTCATGT GTCGGTCAAG TATCGGACAG AGAACATCCT GATAAAAGAC 420

ATAGCGGTTG GGATTGATGC CACTGAGATT ACCTGGTAGG TCTGGTAAGA GGTTGGCAAG 480

ATCAATCTGC ATAAAATCCT CAACCGTTAG ACCAGTATTG GTCTTGAAAT GCGCAGACAA 540

ACTATCTAGG TCATTGCGAT AGATCAAGTT ATCGATACCG TCGACCTCGA GGGGGGCCGT 600

ACCCAGATTT GCAAGCTTGG TAGGATAAAG AACTGGGCAG TTTCACCACC ATTGTCTCCC 660

CAACCCGTTA CGATGACTTC TTTAATCTGA TTGGCACGGC AGGCTTTATT AGCCTCGATA 720

GCCACTAGAC GGCTAAAATG G 741

(2) INFORMATION FOR SEQ ID NO:210:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1349 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: 1inear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:210:

AAACTCGATT TGAGAGAAAG TCCAATAAGT CTTTCCATAA TAAAACGCAT AGTAGCAAGA 60

GTTTCTACAC CCACTATTAT GCGTTTTT T CATTTTGAAA TCTACTGCTA ATCAATGAAG 120

AAGCAAAGAT CAAACTAGGC AGCTAGTTAC AAGTTACGTA AGCGCGTCAT AACAAGGTAT 180

CTATCCTAAT TCCCCAACTT CCAGTATACT AGATAAAAAA TAATTATCGG AGGAAAGGTA 240

TTGTACTATG ATAATTCAAC TAAGTGATTT AGGTCAAGTT CACCTTGTTT GTGGCAAGAC 300

AGATATGAGG CAGGGAATAG ACTCATTAGC CTATGTAGTT AAAACCCACT TTGAATTGGA 360

TCCTTTCTCC GGTCAAGCCT TTCTCTTTTG TGGTGGACGT AAAGACCGCT TTAAAGCCCT 420

TTACTGGGAT GGTCAAGGAT TTTGGCTACT ATATAAACGC TTTGAGAACG GAAAACTGAC 480

TTGACCAAGT ACAGAAAAGG ATGTCAAAGC TCTCACACCA GAACAAGTAG ACTGGCTTAT 540

GAAGGGCTTT TCTATCACTC CCCAAATATA GTGGATTTAA ACTAGAATAG TACACCCCTA 600

CTTCTAAAAC ATTGTTAGAA ATCGATTTGA CTGTCCTGAT CAATTTGTCC TGTTCTTATT 660

TCATTTTACT ATAGAATCCA TCTGAAAGCC GTTTATGATT TCTATTGAAA TGAAGACCGT 720

CCATTTTAGT AGACTAAAGG ATTACTCAAA ACTTCGAGAA GGAAGACAGA TGAACTTGTT 780

TCTTATAAAA ATGTTGTCTG AAACTATTCG CTTTTTTCCA GAAATTTTAG AGGAAGAAAA 840

CTTTATGAGG AAAAAGGAGT TACTCAAATA AC ATTCAGG AT AAAAATA GACAGTTGAG 900

GAGCGGAAGG TATAAATTAA GTTTGCTACT GTATAATGGA TTTAAATCAC TCAGCAGACA 960

GAACGAATAC TCTTCGAAAA TCTCTTCAAA CCACGTCAGC TTCGCCTTGC CGTAGATCCA 1020 TAGGGGACTG GACTTCATCA GTTCTATCAA CAACCTCAAA ACAGTGTTTC GAGCTGACTT 1080

CGATCAATTT TATCTGCACC TCAAAGCTGT ACTTTGAGCA AGCCTGACGA CTAGCTTCCT 1140

ATTTGATTTT CATTGAATAT CAGAAACTCA TTCTCCATCA AATAATTCGA CTGCGTCTAA 1200

TAATTTTTGG TCTGGCACGG TGTCAGAAAT AAAGGTTGTG TATTTGGAGA GGGGATTAAT 1260

TTTAAAAAAT CCAGTCTTGT AAAATTTAGA ACTATCAATC AGTAAGATGG TTTCATGGGC 1320

TTTGTCAATA ATATTCTTTT TTGAAATAG 1349

(2) INFORMATION FOR SEQ ID NO:211:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1359 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:211:

CTTTTTTATA AGCAATTCAA TTTTATACTC ATCTGCTTTC AAAAAGCATT CTAGTCCATC 60

TCCGATTAAC GATGGACTTT ATCACCTCCT TCTCCAATCC TTGTATGACA TCTTGAAGTT 120

GATTCATGAC ATCTTCCAAA ATTCGAAAGG CTTTATTCTT AAATCCACGT TTACGAATCT 180

CTTTCCACAC TTGTTCAATG GGGTTCATCT CTGGTGTGTA TGGAGGAATA AATGCAAAAC 240

CAATATTAGT CGGAATCTTT AAGACACTTG ATTTATGCCA TATAGCATTG TCCATAACGA 300

GTAAAAAATA ATCATCTGGA TAAGCTTGTG AAAGCTCTTC TAAAAAGGCG TTCATCCACT 360

CAGTATTACA TCTACCAGCT ATTAAGAAAA AATGATTCCG CCTGTTATGG GCATCAACAG 420

CTCCATAACA ATAGTGAAAT TCTCGTATAT AGTGACTATG GACATGTGGA CCTACTCCTA 480

TTGGAGACCA ACAAGATCCC AGTTTACTGA TTCTACCGAA ACCAGCCTCA TCTTGGTACA 540

TCAAGCGAAC CTTATGAAAA CGTCTACTGG TTTAAATCGC TTTCTTGTCT TCTTGAATTG 600

AGATTTTATT TTTAGACGCG ACAATGGTTT GAGCGTCTGC TTTCTTAGGA TGTTCTGGAC 660

GTGGCATAAT ATTTCGCCAG CCATGGCGCT TCAACAGTTG ATAGAAGGCA TCACGTGTGT 720

AGGAACGACC TAACTCCTTT TTATAAGCCT GAAATAAGGC ATCAATTGTA ACAAATTCTC 780

CTGCCTCTGT AGCCTTCAAA TGGCGGGCAA GAAATACTTT CTCTTCCTCA ACTGTCATAT 840

ATGCATGGTT ACACCACCAC TTTCCTGATA GAGTTGTTCA CATCTTATTT CAAACTACTA 900

TAAAAGTTCT ATAATCTCTT TATAAGATTT GCCCATCAGA CGAAATATAA TAAATTGAAA 960

CTAGAATAGT ACACCTCTAC TTCTAAAACA TTGTTAGAAA TCGATTTGAC TGTCCTGATC 1020

GATTTGCCCT ATTCTTGTTT CGTTTTACTA TAGAACGATT TGAAGGCGTT TATGATATTG 1080

AGCTGTACGA GAGTCTTTTA AAAGTGTTTT GATGGCTTGG ATTTCTTCTT TAGTTGATTT 1140

CATATCACTA TTATATAATG CTTTTTGATC TTTAGTTTAG TATTATCGTA GAAAATGGAC 1200

TAGGTGCTAT GGATACACCG GATGAGAATG GTTATGTAGC AGATGACTAT CGGATTACTT 1260

ACTTAGAGGC CCACATCAAG GCCATGCGAG ATGCCATTTA CCNAGACGGG GTTGACTTGC 1320

TTGGTTA AC GACTTGGGGC TGTATCGATC CAGTTTCAG 1359

(2) INFORMATION FOR SEQ ID NO:212: ( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 1082 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:212:

CTAGTATTTC CGTTGTGNTT AGTTTGTCTG CCTATGGAGT TATTGCCTAT GTGCAAGGTC 60

AGNTGGATAT TCTTCTAGTG ATTCTGGCCA TGATTGGTGG TTTGCTCAGT TTCTTCATCT 120

TTAACCATAA GCCTGCTAAG ATCTTTATGG GTGATGTGGG AAGTTTGGCT TTAGGTGGAA 180

TGCTGGCAGC TATCTCTATG GCTCTCCACC AAGAATGGAC TCTCTTGATT ATCGGAATTG 240

TGTATGTTTT TGAAACAACT TCTGTTATGA TGCAAGTCAG TTATTTCAAA CTGACAGGTG 300

GTAAACGTAT TTTCCGTATG ACGCCTGTAC ATCACCATTT TGAGCTTGGG GGATTGTCTG 360

GTAAAGGAAA TCCTTGGAGC GAGTGGAAGG TTGACTTCTT CTTTTGGGGA GTTGGGCTTC 420

TAGCAAGTCT CCTGACCCTA GCAATTTTAT ATTTGATGTA AGAATGGCAC CCTGATGTTT 480

TAGGGTGTTT TTGTGTTTAA ATACACAATG AAAATCAAAG AACAAACTAG AAAGCTAACT 540

TTAGGCTGCT CAAAACATAG TATATTGAAA CTAAAA AGT ACACCTCTAC TTCTAAAACA 600

TTGTTAGAAA TCGATTTGAC TGTCCTGATT ACGATTTATC CTGTTCTTAT TTCATTTTAC 660

TATACCATCA ATAAGTGTTG AAAAGATCGT TGACAGAACT GACCAAGCCA GATCATCTTT 720

GTAACCACCT TGAGCTTGTA GCATATTTGT TAATTGAGCA AAGGCGCTAG AAGAGTTTGC 780

TGGGTCAGCA GTTGCGATTT TTCCTTTTAG TTCAGGTTTG AGAAGGTCGC TATATCCTTC 840

GATGTTCATG CCTTTAGTTA AATCAGGGTG GACGATTAAA ACACTACCAT CTAGTGTATA 900

AGGAGTAGAG AAGCCAGTTG TGTTTTGATA TTCTTTGATA ACATTATCAT TTTCTTTTGA 960

AATATAGTTT TCAAAGAGTT CTCCGTGGGT AGCATATTGT GTTATAAGAA CCACCAAAGA 1020

TAACATCAGC TACAGGAACT TCTTTTTCTG ACCTAGTTTT TTGAAAAGTT CTCCAG ACC 1080

AG 1082

(2) INFORMATION FOR SEQ ID NO:213:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:213:

CTGGACTTGA TAGGCATCTT TGTAATCCTC TAAAGCCTCT TTCATCAAGG CACTACCAAT 60 TCCTTGACGC TGATAGATTG GTAAAACGAT TAAATCCTGA ACCAATACTG ATGAGAATCC 120

ATCTCCAACC AAACGAATCA AGCCCACCAC AGCATCACCA TCAAGTGCCA CATAAATTAC 180

TAATGAATGA GATAAGGCCT GCTCCAGCAT CTCTGGTTGA TGGGTATAAT TAGTCCAACC 240

GACAGCCTGA TAGACATGTA AAACATCCTC TAGCTTGACA ATTTCTTGCT TTTTAATAGT 300

AATCATCTCA ACACCTCTTA AAGTTCTCTC AAGCTCTTGT ACTGCTGTCC ATTTTTATCA 360

AAATTTTCAG GACGCAACCA TGTTTCCAAA CGATCTTTGA CTTTGGGCCA GTCCTTATCA 420

ATCATAGACA ACCAATCCAT ATCTCTCGTA CGCCCCTTAT AAACCACTGC CTGACGGAAG 480

GTTCCTTCAT AAATAAAGCC CAAACGCTCC GCAGCACGTC TGGATGGCAG GTTAAGAGCA 540

TCGCATTTCC ACTCATAACG ACGATAGTTA AGCTCTTCAA AGACATAGCG AGCCAGTAGA 600

TACTGGGCTT CTGTCCCTAT CCGTGTCCCC CTGAGTTTTG GAGAAAAAGT GACAGCTCCC 660

ACTTCTATTA CTCCGTTACT GGTCAATACG CATGAGAGAA AAATTCCCAA AGCCTTACCA 720

GTTGCCTTGT CTATGTAGTA AAAACGGTCC TTACGAGCCA ACATCTGACT ACTATAGTAG 780

ATTGAAACTA GAATAATATA CCTCTACTTC TAAAATATTG TTAGAAATCG ATTTGACTTC 840

CCTGATCGAT TCGTCCTATT CTTATTTCAT TTTAATATAA TTGATAGTGG TCGCCCCAGC 900

CAGATACCTT ATCTGCTATC CATTTAGGAA CCCCTAACTT AAGCAATCCC CATAATCGTC 960

TCGATTTCTT CTTCCATTGC TTCCAGATAA TCACTCGTAG GCGAGTACGC AAGCGCTCAT 1020

CTATGTTAGT GACTATACTT TTCATATTTA TAATTCATTC CTTTCGTTTC ACTCAAGGCA 1080

CAACACAGAA TGAAAAAGTG TTGTGATCTT TATTTTGTTT TATAATAATA GTGAGAAAGC 1140

CTATCACTAC TACAAATCAC GGGGAGGTGA ATAAGTGAGT GGTACAGCCA CTACCTCGCA 1200

TATTTTGTCA CATCATTTAA CGGTACATAA TAAGTTGTAC CATCTGAATA AGTTGCTACA 1260

ATATCATTTG CATGCTCTCC TTCACCTTTA GCAAAGGTTG GAG 1303

(2) INFORMATION FOR SEQ ID NO:214:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1567 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:214:

CTCTTCAATC AACTCACGCT TTAGGGCTTC CTGATGATTT TCACCTGCTT CAATTTCTCC 60

ACATGGTAGG AACCAAGCAC CATTTGGTTC TTGAACAAGA ACAATTTGTT TTTGTTCAGG 120

ATTAGGGATA ACTGCATATA CGCCATAGCG AGCAATATAG TCTGTATTCG CTTTTTTCTC 180

CGAAAGTTGG GTTTGCCATT GCATTTTCCT CATTATCTAG TATCGTTATT AT ATAGTGA 240

AATGAACCAA AAATAGTACA CAATGTGGTA TAATCTTTTT ATGGCATATT CAATAGATTT 300

TCGTAAAAAA GTTCTCTCTT ATTGTGAGCG AACAGGTAGT ATAACAGAAG CATCACACGT 360

TTTCCAAATC TCACGTAATA CCATTTATGG CTGGTTAAAG CTAAAAGAGA AAACAGGAGA 420

GCTAAACCAC CAAGTAAAAG GAACAAAACC AAGAAAAGTT GATAGAGATA GACTTAAAAA 480

CTATCTTACT GACAATCCAG ACGCTTATTT GACTGAAATA GCTTCTGAAT TTGGCTGTCA 540

TCCAACTACC ATCCACTATG CACTCAAAGC TATGGGCTAC ACTCGAAAAA AAGAACCACA 600 CCTACTATGA ACAAGACCCA GAAAAAGTAG CCTTATTTCT TAAGAATTTT ANTAGTTTAA 660 AGCACCTAGC ACAGGTCTAA CAAATGGTGA ATTAATCGCT CCAATGACTT ACGAAGAGAT 720 GATGACGAGC GACTTTTTTG AAGTATGGTT TCAGAAGTTT CTCTTACCAA CATTAACCAC 780

ACCATCGGTT ATTATAGTGA AATGAAATAA GAACAGGACN AATCGATCAG GACAGTAAAA 840 TCGAATTCTA ACAATGTTTT AGAAGTAGAG GTGTACTATT CTAGTTTCAA TCTACTATAT 900

TAATGGACAA TGCAAGATTC CATAGAATGG GTAAGCTAGA GTTCTTATGT GAAGAGTTTG 960

GGCATAAACT TTTACCTTTT CCTCCCTACT CATCTTAGTA TAGAAAAGTG AATCTAAAAT 1020

AGTACATAAC TGCTTCTAAA ACATTCTTAT AAATTGATTT AAATTCTCAA ATCATAT T 1080

TCAGTTCTTA TTTCATTTTG CTCTACAATC CTGTTGAGAA GACACGTGTT CATATCAAAA 1140

AGGTATTGGC AAGTTGCAAT ACCTTTTTAC AAGGTTCTTT TGTCTTATTT TTGTTTCAAC 1200

TGACTA ATC TCCTATGGTT CTAGTTCAGA AGGCTAGGCT ATAATTATGA TTGATAAGAA 1260

GTATCATTCC AAGTATTGAG AGTGAATGTT TCAAAATCAT GGGTTTCTAT AATGGTCAGG 1320

CTGGCATTTG CTAGACCGCC ATCTTTACGA AGAAGTGGTT CTTTATAGCC TAGGAGAGTA 1380

CGAAGACTGG CAGTAAGATT GGCGCCGTGT CCGACAATTA GAATACGCTC AGCTGGACTA 1440

TCTTTTAATG ATTTGATAAA TTGGATGGTC CGCTGAGTTG TACTATAGAG GGATTCGGCT 1500

CCGAACATTC GAGTGTCAAA TTGAGCAAGA TTTGAACGAA AAGCCTGGAT TTGTTGCGGG 1560

TAAATAG 1567

(2) INFORMATION FOR SEQ ID NO:215:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 486 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:215:

CTGTTTCCAT AGCATGACTT CTGTACTAGA CTTTCTTTTC CGAATAAATA GATAGAACCA 60 CAGAATCTAG TAAACCTAGA ATTAAAATTA TGGTATAATA TTAGCAATAA AAGAAATCTG 120

GAGGATTAGA ATCATGGTAT CAACGAAAAC ACAAATTGCT GGTTTTGAGT TTGACAATTG 180

CTTGATGAAT GCAGCAGGTG TGGCTTGTAT GACGATAGAG GAGTTAGAAG AGGTCAAAAA 240

CTCAGCGGCA GGAACCTTTG TTACTAAGAC AGCGACCTTG GACTTCCGTC AGGGGAATCC 300

TGAGCCACGC TACCAAGATG TTCCACTTGG TTCCATCAAC TCTATGGGCT TGCCAAATAA 360

TGGCTTAGAC TATTATTTGG ATTATCTTTT AGATTTGCAG GAAAAAGAGT CGAACCGAAC 420 TTTCTTCTTA TCTCTGGTCG GCATGTCTCC AGAGAAACCC ATACTATTTT GAAAAAAGTC 480

CAGAGA 486

(2) INFORMATION FOR SEQ ID NO:216:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 814 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:216:

CTCTATCAGG AAAGTTAAAT TAATTTATAG AAATATTTTA GTATTTAAGC CCTACTGTTA 60

TAGATTCAAT ACACTATATA TGTGTTTGTC TGATAAAAAT TTCTACTCTT TTTGATTTTA 120

AATAAGTATT AGTTTACATT ATGGTGTGAA TTGGGTTTGA TATCTCTTTT GAGGAAGTTG 180

CCTTAGATTT TTCTGATTGT GTTTTATTGT ACAGTGTATC TTGCTTGTTT TGAACAGAAT 240

TTTTTATGAC ATTTGTCATA TTTTCTAGTG ACAGAAGCTT CTGCCTCCTC TGATTTTAAA 300

AGACTATAAT TGTAGTATGA AATGGGGGAA GAAGAGATGA GAAATAAAAT GATTATCGCA 360

GTAAGTTTAG TAGTAGCAGG AGTTATGACC TATCTCATGT TTTCGGGATT GGATGAGAAT 420

TTCTACCATT TTCCTTGGGA GGTCTTTGCT GGCTTTGGAA TCATCTTCTT GGCTTGTCCA 480

GAGAAGGTTT GAAATTAGTA AGAGATGTGA AAAAGGAGTT TGAAAAATGA AAAAAGCAAC 540

TATCTATTTC TTTATCGGCC TGTCACTCTT GGTATGGTTG GTAGAAATGT TTACAGGTTG 600

GTTTGCTCAA ACCTTCCTTC ACCAGTTCAT CCGTGGTGCA TGGGGATTAG GATTTATGAT 660

TTTTATCGCC TTTCCGATGG GAAAGGAGTT GCTGGAAGGA GAATATCATG AACATGATTA 720

AGGTTCAAGG ACTACATAAA AATATTAAGG GCAAGGCTAT TTCAAAGGAT ATTTCCTTTG 780

AAGTAGCAGA AGGTGAATGC GTTGCCTTGA TTGG 814

(2) INFORMATION FOR SEQ ID NO:217:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1319 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:217:

CTTGGTACGA CCGTATGGGT GGTCACTGAA AGTGGGAAAC TTCCAAGATG GGCACTGTGT 60

ACGGATCCCC GTAAACTGTC GCANAAGAAC TGAAGATGAT GTTTTTACAG TTGTTTTCTT 120

CCATGGCTTT CAAAAGGCTG ACAGTTCCAG CGATATTGTT GTCATAGTAG GCAAGAGGGA 180

TACGTGTTGA TTCGCCAACA GCCTTCAAAC CAGCAAAGTG AATGACACCA GTCAGTTCTT 240

CCTGCTTGAA AATATCTCTG AGGGTATCTG TGTCACNAAT ATCTGCCTCA TAGAAAGGAA 300

TCTCAACTCC TGTGATTCTT TCAACAACTT CTAAACTCTT ACNATTGCTA TTGACAAGAT 360

TATCCACCAC AACAACTTGA TGGCCTGCTT GGATCAATTC AATAACAGTG TGGGTTCCAA 420

TAAAACCGGC ACCACCAGTT ACCAAAATCT TTTCTTGCAT CTTTTTTCCT CGATTCTCAG 480

ATTATTTTTT CTTATTTTAA CCATTTTTGA CAGGGAATGT CATTTGCCAC CTTAAACTAC 540 CTGATAAAAT TTCAGTAAAA TGCTTATACT CTTGGAAAAT CCAATTCAAA CCACGTCAAC 600 GTCGCCTTGC CATGGGTATG GTTACTGACT TCGTCAGTTC TATCCACAAC CTCAAAGCAG 660 CGCTTTGAGT AACCCGCGGC TAGTTTCNTA GTTTGTTCTT TGATTTTCAT TGAGTATTAT 720 TCGCTTTTTA CTCGTTTGAC ATAGTTTTCA ATTGGGTAGT TTTCAGGGTC CAAGGTCAAC 780 TCCTTGTCTT GGATCAGTTG AGCTAAATGG TAACCAATAA TAGGACCAGT TGTGAGGCCT 840 GATGAACCTA GTCCACTGGC TGCATAGACA CCAGTTAAGT CAGGCACCTG CCCAAAGAAA 900 GGAGAGAAAT CACTGGTGTA GGCACGGATT CCAACACGCT CAGATTTTGA AGTAGCTTCA 960

GCCAAAATCA GATAGTGAGT CAAGGTGGCC TCCTCCATTT GTTGGAGCAA GGTTTCATCT 1020

ACCGTCAAAT CAAATCCCAT GTCATTTTCG TGGGTAGCGC CTAAGGACAA TTTCCCACCT 1080

GCAAAAGGAA TCAAATCCCA CTCCCCTTCT GGCATGACAA CAGGGTAAGC TTCCATGTCT 1140

TGGACCAGCT GATAATCTCG TAGTTGTCCT TTTTGAGGAC GAACATCTAC TTCATAACCC 1200

AAGGGTTCTA ACATGTCCCC CAACCAAGCT CCNGTCGCCA AAATAACCTG CTCAAACTCC 1260

TCTTCACCAA TCTGGTAGCC TGATGCTAAC GGTGTCAGAG TCACTTTTTC TTTGACCAG 1319

(2) INFORMATION FOR SEQ ID NO:218:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 534 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:218:

CTCAAAATAC TGTTTTGAGG TTGCAGATGG AAGCTGACGC GGTTTAAAGA GATTTTCGAA 60

GAGTATAAAC TGCTTATAAA ATAAAAAGGA GCCCTGATGG AACACATTAT TTATCAGTTT 120

GAAGAGGACT TGGCAATCCT TACCTTGAAC CGTCCTGAGG TCGCAAATGG TTTTCATATT 180

CCCATGTGTG AGGAGATTTT AGAAGCTCTG ACTTTGGCAG AAGAAAATCC AGCTGTGCAT 240

TTTATCTTAA TCAATGCCAA TGGAAAGGTC TTCTCAGTTG GGGGAGATTT GGTAGAGATG 300

AAGCGGGCAG TGGATGAGGA TGATATTCCA TCATTGACAA AAATCGCAGA GTTGGTCAAT 360

ACGATTTCTT ATAAAATCAA GCAAATAGCC AAACCTGTTT TTAATGGAAG TTGACGGTGC 420

TGTTGCAGGT GCCGCAGCGA ATATGGCTGT TGCGGCAGAT TTCTGTTTGG CGACGGATAA 480

GGCTAAGTTT ATCCCAAGCC CTTTGTTGGT GTGGTTGGCT CCAGATTCCA GGGG 534

(2) INFORMATION FOR SEQ ID NO:219:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 784 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:219:

CTGCAGCCGG AAGTTATCTG GTTACAAAAA ATCGCCAAAC CATCACAGAT GAAAGTCTTG 60

AATACCACTG ACCGCGTTCA AGCTATCAAG GACGATGTGG ATATTATCCA AAACAGCCTG 120

CAAATCATTA ACCAGCAAAA AGAACTTATC AAGGAATACC AAGAAGACTT GACTTACAAG 180

TTTAAGGTCT TGGAAAAGGA TATCCAAACT AGGACTAGCT GTGATAAAAG AAATGCAGGG 240

AACTGAAGAT AAGTAAAAAG AGCCCGACGG CTCTTTTTTA AAACGTAAAC AAGTTATAGT 300

GAATTGAATT TAGAATAGCA CATCATAGTT TCTAAAGCAT TGTTAGAGAT TACTTTAAAA 360

TCCTCTTATC AATTTGTTCA TATTCTATTT CAATCTACTA TATATATCCC ATCAACTATG 420

CATCATAATT TAGGTAACTC ATACTCAATA AAAATCAAAA AGCAAACTAG AAAGCTAGGC 480

ACAGACTGCT CAAAACACCG TTTTAAGGTT GTGGATAGAA CTGACGAAGT CAGTAACCAT 540

ACCCATGACA AGCCGACGCT GACGTGGTTT GAAGAAATTT TTGAAGAGTA TCATTCACCA 600

TTTCACAACT AAATCGAAGA CTTTCTGCCG TAATGAAAAC ACCTGAAACA GCTTGGTTTC 660

AGCTGTCCGG AAACTTTAAG ACTTAGGTTC AAAGTT AGG TATGGAACTT CGAAGGAGGT 720

CGCTACCGTC CGTCATTACT TAGNGAAGNC TTAAAAAATC TATAAAGTAA AAAGAGCCCG 780

ACAG 784

(2) INFORMATION FOR SEQ ID NO:220:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 962 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:220:

CTACTCGTTT TAGTATAGTA AACTGAATCT AGACTAGCAC AATGCNGCTT CTANAGCGTT 60

TCGAAACTAG AATAGGACAA CATAACTGCT AAAAGATTTC TATAAATTCA TTTGATTTTC 120

CTAATCAATT TGTTCGTATC CTANTTCACT CCACTATAAA ATATTCTTAT CAATTGATTT 180

GNATGCCAAA ATTCCATCGT TCAGGTCTTA TTTCATTNGG CTNTAAAAAA CTCTCCTGGG 240

NAATCCCAGG AGAGNATGAT TACNTATTTG AACTTGAATC CTTCGTANAT AAGCTCTGTT 300

TTTGGATTTT GTTTCTTAAT CTGTTTGGCA AGTGCCTTCA TCATAGAAAT AGGACCACAC 360

ATATAGACGG TTGCATGTTC GGGCACTTTT TTTGTTCAAA ATTAAGATAG CCGTCTTTCG 420

TACTGTCGAT TAGATGGAGT TCAAAATTAG GATTTTTCTG AGCATAGTTA CGGAGTAAAT 480

CTAGGTAGAC TGCATTTTCA TCTCCACGGA AGCTATAGTA GAAGTGAACC TGTTTATCTA 540

AAATAGGATG TTCACGGATG TAAGAGATGA AGGGGGTGAT CCCAATACCT CCAGCAATCC 600

AAACCTGATT TTCTCGTCCT TCTTCTATGA TCATGTGTCC GTAAGCTCTG TCTAGGGTTA 660

CTTTGCTGCC GGCTTGAAGA TTATCATAGA TATTTCTTGG TATGGTCGCC TGAATTTTTA 720

ACAGTAAAGT TAAAGAGTTT GAACCCATGA ACTCCCTGAG AATAGAAAAG GGATGCCGGA 780 ACCACTTTCA AAGCCTTCTT GGAAAATCTT TAGAAAGGCA AATTGTCCTG ATTGATAGTT 840

GAAAGGTCTG CTAAGATGGA TTTGAATTTC TCTAGTATCG TGATTTAAGC GTTTGAGATG 900

GGTAATTTTC CCTAGATAGG GGAAGGAAAT CTTTTGATAT AGAAAAATGA TATAAAAACC 960

AG 962

(2) INFORMATION FOR SEQ ID NO:221:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 910 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:221:

CTCTTTCCAC TATTATAACA CGAAAGAAAG AATTGTCAGG GAACTGTACA GATTTCTTTT 60

CTATCTATTT ATAACTCAAT GAAAATCAAA GAGCAAACTA GGAAACTAGC CGCAGGCTGT 120

AATTGAG AC GGCAAGGCGA CGTTGACGCG ATTTGAATTT GATTTTCGCA GAGTATTATT 180

CGTAAAAAAT CTCAAAAAGC CTACCTTTCG GTAGACTTAG TTTGTTTCTA TTCTAATCGG 240

CACTCTTCCA AAATTTTGCT CTGCTATACT TGGCTTTCCT AGTTGGTAAA TCTGGTCAAC 300

CTTTTGAGTC ATAGCATCCC AAGGTTCTTT GCCAATTCGG CTGACTAGAT TGACCTGTCC 360

TTTCAGAGAC TTGAGATGTT GCCTGCCTTT TTCAGTAAAT CCAAGGACAT GAATGGCTTC 420

TGGCAAGTCA CTTTCTCTAG CCTGCATCAA AATATAGGTC AATAGGCGTC TGACACGCGC 480

CTTGGTGTAA CGTTTGGTAG TCACTAACTC GACCAATTCT TCCACAGACT GGGCTGTTTT 540

AATAGCTTCT TTAATGCGCA CAGCCATTTC TTGATTGACC TGATAGATGG TGGTTAGGTC 600

GGGATTTGAC AAGATTTGAT AGCGGAGCAA GGGAAAATAG TCTTCCCAGA TCACCTTACT 660

GGCTTGCTCA AATAGGGCAA CAGAAGGCAT AAAACGTTCT AAGAAATCTT GGTCCTTCTG 720

ATGTTGACGG AGGGCTGTCG CCGAGGCAAA GTCCACATCT TTATTCACAG AATGGTAACC 780

TGCCCCCTGA CGCTGAATCG GATGCAGCTT GATATTCCGT CCTGCAACCG CCTTGGCATA 840

GGCCAAAACA AAGAACATGA TTGGGGTGTA TTACCTGAAA AATCAAGACC AGCAAATTCC 900

TTCCACATAG 910

(2) INFORMATION FOR SEQ ID NO:222:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 866 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222:

CGCCAAGTCA TCCAACAAGT CCAGAACGGT TCTGGGGCTT GGGATCCTCA GTCGCTGGAG 60

ATAACTCCTT TGGGCTTGTT CATCATGTAG TAGACAAACT CTTCATACTC CAACACTTGC 120

CCATCAAAAG CGAATCTCAT CTATTTTTTC ATCAATCTGC AATTTAGCTG ATTTTTCTTT 180

TTTACCATTT ACAGTCACGC GCCCAGCCTT GAGCAAGTTT TTGACCTCAG TCCGACTTCC 240

CACCGCACAG GCAACTAAAA ATTTATCTAA TCTCATAGAA CTATTATATC ATATCAAAAG 300

GAGGCTGGTA CAATGACCAA CCTCCTTTTC GTTTCATACT CTTCAAAAAT CTCTTCAAAC 360

CGCGTCAACG TCGCCTTGCC GTATATATGT TACTGACTTC GTCAGTTCTA TCTGCAACCT 420

CAAAGCAGTG CTTTGAGCAA CCTGCGGCTA GTTTCCTAGT TTGCTCTTTG ATTTTCATTG 480

AGTATCAGAT TTAGGAAATT AACTTCCTCG TCTCCAAAAA ATAGCTAAGA CAATCATGGC 540

ACCTAAAACA GCTGGGATAA TAGCTGTTCC TGATAAAACT GGCCCCCAAG TTCCAAAGAG 600

CAAGTGACCT AGAAAGGCTC CGATCCAACC GAGAAACATT TTTCCAAAAC ATCCCATTCG 660

CTCTCCACGA TTGGTCATAG CACCTGCTAA AAATCCCACT AGGAGACCAA CGAACATACT 720

TCCTAACATA TTATCTCCTT AATTTGCCCA ATTCCCATTA CGGAAAAGAA GTACTCGCGT 780

TCCATCCTCA CGAATACCAT CGATATCCAT TTGGTTAGAA CCAATCATAA AGTATACGTG 840

AACATCTGAA CGGTTAAGCC CTGCAG 866

(2) INFORMATION FOR SEQ ID NO:223:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 693 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Genomic DNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:223:

CTTCAGGATG TGGGAAAACG ACCCTTCTTC GTATGATTGC AGGTTTCAAC AGTATCAAAG 60

ATGGAGAATT TTACTTCGAT GATACAAAAA TCAATAATAT GGAACCCAGC AAACGCAATA 120

TCGGGCTGGT TTTCCAAAAC TACGCTATTT TCCCACATTT GACTGTCCGA GACAACGTTG 180

CTTTTGGTCT TATGCAAAAG AAGGTTCCAA AAGAAGAATT GATTCAACAG ACCAACAAGT 240

ATCTTGGACT CATGCAAATT GCTCAATATG CGGATCGAAA GCCCGATAAA CTCAGTGGTG 300

GACAACAACA ACGTGTCACC TTGGCATGCG TCTTAGCGGT TAATCCAAGT GTTCTCCTCC 360

ATGGACGAAG CCACTTAGTA ATCTGGAGGC CAAACTTCGC TTGGATATGC GTTCAAGCCC 420

ATCCCGAGAA ATCCAACCAC GAAGTTGGGG AATTACAACT GTTTATGTAA CCCACGACCA 480

AGAAGGAGCC ATGGCTATTT CAGACCAAAT TGCCTGTTAT GAAAGATGGG GTGATCCAAC 5 0

AAATCGGCCG ACCAAAAGAA CTGTATCATA AACCAGCTAA TGAGTTAGTG GCAACCTTTA 600

TCGGACGCAC AAATATTATC CCTGCCAATC TTGAAAAACG GAGCGACGGC GNTTATATCG 660

TCTNTTCAGA TGGANANGCC CTTCGAATGA TAG 693

(2) INFORMATION FOR SEQ ID NO:224: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:224:

Met Ser Met Phe Thr Met Val Lys Met Aεn Pro Leu Arg Gly Leu Ile

1 5 10 15

Cys Asn Leu Lys Gly Asn Lys Ile Thr Ala Leu Ile Gly Pro Ser Gly

20 25 30

Ser Gly Lys Ser Thr Tyr Leu Arg Ser Leu Asn Arg Met Asn Asp Thr

35 40 45

Ile Asp Ile Ala Lys Val Thr Gly Gin Ile Leu Tyr Arg Gly Ile Asp

50 55 60

Val Asn Arg Pro Glu Ile Asn Val Tyr Glu Met Arg Lys His Ile Gly 65 70 75 80

Met Val Phe Gin Arg Pro Asn Pro Phe Ala Lys Ser Ile Tyr Arg Asn

85 90 95

Ile Thr Phe Ala His Glu Arg Ala Gly Val Lys Asp Lys Gin Val Leu

100 105 110

Asp Glu Ile Val Glu Thr Ser Leu Ser Gin Ala Ala Leu Trp Asp Gin

115 120 125

Val Lys Asp Asp Leu His Lys Ser Ala Leu Thr Leu Ser Gly Gly Gin

130 135 140

Gin Gin Arg Leu Cys lie Ala Arg Ala Ile Ser Val Lys Pro Asp Ile 145 150 155 160

Leu Leu Met Asp Glu Pro Ser Leu Ser Leu Gly Ser Asp Cys Asp His

165 170 175

Ala Thr Arg Arg Asp His Val 180

(2) INFORMATION FOR SEQ ID NO:225:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 247 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:225:

Met Ile Lys Ile Ser Asn Leu Ser Lys Ser Phe Ser Gly Gin Thr Val

1 5 10 15

Leu Asp His Leu Asn Leu Asp Ile Gin Lys Gly Glu Val Val Ala Leu

20 25 30

Ile Gly Ser Ser Gly Ala Gly Lys Ser Thr Phe Leu Arg Ser Leu Asn

35 40 45

Tyr Leu Glu Thr Pro Asp Ser Gly Ser Ile Gin Ile Asp Gly Phe Ser

50 55 60

Val Asp Phe Ser Lys Ile Thr Gin Glu Glu Ile Leu Ala Leu Arg Arg 65 70 75 80

Lys Leu Ser Met Val Phe Gin Gin Phe Asn Leu Phe Glu Arg Arg Thr

85 90 95

Ala Leu Asp Asn Val Lys Glu Gly Leu Val Val Val Lys Lys Leu Ser

100 105 110

Asp Gin Glu Ala Thr Lys Ile Ala Lys Glu Glu Leu Ala Lys Val Gly

115 120 125

Leu Ser Asp Arg Glu Asn His Tyr Pro Arg His Leu Ser Gly Gly Gin

130 135 140

Lys Gin Arg Val Ala Leu Ala Arg Ala Leu Ala Met Lys Pro Asp Val 145 150 155 160

Leu Leu Leu Asp Glu Pro Thr Ser Ala Leu Asp Pro Glu Leu Val Gly

165 170 175

Glu Val Glu Lys Ser Ile Ala Asp Ala Ala Lys Ser Gly Gin Thr Met

180 185 190

Ile Leu Val Ser His Asp Met Pro Phe Val Ala Gin Val Ala Asp Lys

195 200 205

Ile Leu Phe Leu Asp Lys Gly Lys Ile Ile Glu Ser Gly Thr Pro Asp

210 215 220

Glu Ile lie His Thr Pro Lys Glu Glu Arg Thr Lys Glu Phe Phe Thr 225 230 235 240

Ser Tyr Lys Arg Thr Tyr Ile 245

(2) INFORMATION FOR SEQ ID NO:226:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:226:

Met Phe Ser Leu Arg Ser Val Phe Asp Gly Ile Pro Arg Ile Val Gin

1 5 10 15

Gin Leu Pro Thr Thr Ile Met Leu Thr Ile Gly Gly Ala Leu Phe Gly

20 25 30

Leu Val Leu Ala Leu Leu Phe Ala Ile Val Lys Ile Aεn Arg Val Lys

35 40 45

Ile Leu Tyr Pro Leu Gin Ala Phe Phe Val Ser Phe Leu Lys Gly Thr

50 55 60

Pro Ile Leu Val Gin Leu Met Leu Thr Tyr Tyr Gly Ile Pro Leu Ala 65 70 75 80

Leu Lys Ala Leu Asn Gin Gin Trp Gly Thr Gly Leu Asn Ile Asn Ala

85 90 95

Ile Pro Ala Ala Ala Phe Ala Ile Val Ala Phe Ala Phe Asn Glu Ala

100 105 110

Ala Tyr Ala Ser Glu Thr Ile Arg Ala Ala Ile Leu Ser Val Asn Pro

115 120 125

Gly Glu Ile Glu Ala Ala Arg Ser Leu Gly Met Thr Arg Ala Gin Val

130 135 140

Tyr Arg Arg Val Ile Ile Pro Asn Ala Ala Val Val Ala Thr Pro Thr 145 150 155 160

Leu Ile Asn Ser Leu Ile Gly Leu Thr Lys Gly Thr Ser Leu Ala Phe

165 170 175

Ser Ala Gly Val Val Glu Val Phe Ala Gin Ala Gin Ile Leu Gly Gly

180 185 190

Ala Asp Tyr Arg Tyr Phe Glu Arg Phe Ile Ser Val Ala Leu Val Tyr

195 200 205

Trp Val Val Asn Ile Gly Ile Glu Ser Leu Gly Arg Phe Ile Glu Arg

210 215 220

Lys Met Ala Ile Ser Ala Pro Asp Thr Val Gin Thr Asp Val Lys Gly 225 230 235 240

Asp Leu Arg

(2) INFORMATION FOR SEQ ID NO:227:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:227:

Met Tyr Arg Ile Asp Asp Asp Glu Gin Phe Val Leu Asp Phe Leu Lys

1 5 10 15

Gin Glu Lys Val Leu Leu Val His Gly Arg Gly Phe Asn Trp Gin Glu

20 25 30

Pro Asp His Phe Arg Ile Val Tyr Leu Pro Arg Val Asp Glu Leu Ala

35 40 45

Gin Ile Gin Glu Lys Met Thr Arg Phe Leu Lys Gin Tyr Arg Arg 50 55 60

(2) INFORMATION FOR SEQ ID NO:228:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 132 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:228:

Met Asn Asp Glu Ala Ser Lys Gin Leu Thr Asp Ala Arg Phe Lys Arg

1 5 10 15

Leu Val Gly Val Gin Arg Thr Thr Phe Glu Glu Ile Leu Ala Val Leu

20 25 30

Lys Thr Ala Tyr Gin Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys

35 40 45

Leu Ser Leu Glu Asp Leu Leu Met Ala Thr Leu Gin Tyr Val Arg Glu

50 55 ^' 60

Tyr Arg Thr Tyr Glu Gin Ile Ala Ala Asp Phe Gly Ile His Glu Ser 65 70 75 80

Asn Leu Ile Arg Arg Ser Gin Trp Val Glu Val Thr Leu Val Gin Ser

85 90 95

Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu Asp Thr Val Met

100 105 110

Ile Asp Ala Thr Glu Val Gin lie Asn Arg Pro Lys Lys Arg Ile Ser 115 120 125 Glu Ser Phe Trp

130

(2) INFORMATION FOR SEQ ID NO:229:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 154 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:229:

Met Arg Arg Lys Tyr Lys Ser Ile Ala Leu Lys Lys Glu Leu Ala Asn

1 5 10 15

His Ser Gly Lys Lys Lys Phe His Ala Met Lys Ala Gin Ala Ile Val

20 25 30

Thr Ser Gin Gly Arg Ile Val Ser Leu Asp Ile Ala Val Asn Tyr Ser

35 40 45

His Asp Met Lyε Leu Phe Lys Met Ser Cys Arg Asn Ile Gly Gin Ala

50 55 60

Gly Lyε Ile Leu Ala Asp Ser Gly Tyr Gin Gly Pro Met Lys Ile Tyr 65 70 75 80

Pro Gin Ala Gin Thr Pro Arg Lys Ser Ser Lys Leu Lys Pro Leu Ile

85 90 95

Ala Glu Asp Lys Ala Tyr Asn His Ala Leu Ser Lys Glu Arg Ser Lys

100 105 110

Val Glu Aεn Ile Phe Ala Lys Val Lys Thr Phe Lys Met Phe Ser Thr

115 120 125

Thr Tyr Arg Asn His Arg Lys Arg Phe Gly Leu Arg Met Asn Leu Ile

130 135 140

Ala Gly Ile Ile Asn Tyr Glu Leu Gly Phe 145 150

(2) INFORMATION FOR SEQ ID NO:230:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:230:

Met Val Ser Ser Ser Gly Ser Glu Phe Gin Ser Gly Trp Gin Glu His

1 5 10 15

Gin Leu Ile Ala Glu Lys Val Ser Lys Thr Leu Asp Lys Thr Phe Asp

20 25 30

Lys Asp Val Arg Lys Ile Pro Thr Ser Pro Val Leu Ser Lys Ile Cys

35 40 45

Arg

(2) INFORMATION FOR SEQ ID NO:231:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:231:

Met Ile Lys Ile Leu Ala Ala Cys Gly Ala Gly Val Asn Ser Ser His

1 5 10 15

Gin Ile Lys Ser Ala Leu Glu Glu Glu Leu Ser Asn Arg Gly Tyr Asp

20 25 30

Val His Cys Asp Ala Val Met Val Lys Asp Val Asn Glu Asp Leu Met

35 40 45

Lys Gly Tyr Asp Ile Phe Thr Pro Ile Ala Ala Thr Asp Leu Gly Phe

50 55 60

Glu Pro Gly Ile Pro Val Ile Glu Ala Gly Pro Ile Leu Phe Arg Ile 65 70 75 80

Pro Ala Met Ser Ala Pro Val Phe Asp Asn Ile Arg Leu Pro Ala Lys

85 90 95

Gin Asn Met Val 100

(2) INFORMATION FOR SEQ ID NO:232:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:232:

Met Asn Thr Lys Met Met Ser Gin Phe Ser Val Met Asp Asn Glu Met

1 5 10 15

Leu Ala Cys Val Glu Gly Gly Asp Ile Asp Trp Gly Arg Glu Ile Ser

20 25 30

Cys Ala Ala Gly Val Ala Tyr Gly Ala Ile Asp Gly Cys Ala Thr Thr

35 40 45

Val

(2) INFORMATION FOR SEQ ID NO:233:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 77 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:233:

Met Arg Glu Lys Glu Ile Phe Asp Ser Ile Val Thr Ile Ile Gin Glu

1 5 10 15

Arg Gin Gly Glu Asp Phe Val Val Thr Glu Ser Leu Ser Leu Lys Asp

20 25 30

Asp Leu Asp Ala Asp Ser Val Asp Leu Met Glu Phe Ile Leu Thr Leu

35 40 45

Glu Asp Glu Phe Ser Ile Glu Ile Ser Asp Glu Glu Ile Asp Gin Leu

50 55 60

Gin Ser Val Gly Asp Val Val Lys Ile Ile Gin Gly Lys 65 70 75

(2) INFORMATION FOR SEQ ID NO:234:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:234:

Met Ala His Gly Asp Leu Leu Tyr His Asp Gly Leu Phe Phe Ser Ala

1 5 10 15

Lys Lys Glu Asp Gly Thr Tyr Asp Phe His Glu Asn Phe Glu Tyr Val

20 25 30

Thr Pro Trp Leu Lys Gin Val Asp 35 40

(2) INFORMATION FOR SEQ ID NO:235:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 102 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:235:

Met Ser Leu Ile Thr His Arg Arg Phe Ile Ser Cys Asn Glu Asn Ile

1 5 10 15

Lys His Tyr Lys Arg Leu Ile Asp Lys Ala Glu Lys Cys Val Asn Asp

20 25 30

Leu Met Ala Glu Leu Asn Ser Val Ile Thr Thr Val Thr Gly Ile Glu

35 40 45

Asn Arg Leu Gly Ala Val Ile Leu Ala Glu Ile Arg Asn lie His Ala

50 55 60

Phe Asp Asn Pro Ala Gin Leu Gin Ala Phe Ala Gly Leu Asp Ser Ser 65 70 75 80

Ile Tyr Gin Ser Gly Gin Ile Asp Leu Val Gly Arg Met Val Lys Arg

85 90 95

Gly Ser Leu His Leu Arg 100

(2) INFORMATION FOR SEQ ID NO:236: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:236:

Met Ile Arg Ala Val Phe Phe Ser Ile Asp Asn Asp Met Glu Glu Ala

1 5 10 15

Ala Arg Ser Met Gly Ala Ser Ser Phe Tyr Thr Met Val Arg Val Ile

20 25 30

Ile Pro Tyr Ile Leu Pro Val Val Leu Ser Val Val Val Leu Asn Phe

35 40 45

Asn Ser Leu Leu Ser Asp Tyr Asp Leu Ser Val Phe Leu Tyr His Pro

50 55 60

Leu Phe Gin Pro Leu Gly Ile Val Ile Lys Gin Ser Thr Asp Glu Thr 65 70 75 80

Ala Thr Leu Asn Ala Gin Ala Met Met Phe Val Tyr Ser Val Ile Leu

85 90 95

Met Ile Met Ser Ser Ala Ala Leu Tyr Leu Ser Ser Leu Phe Gin Gly

100 105 110

Lys Arg Gly Lys Arg 115

(2) INFORMATION FOR SEQ ID NO:237:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 101 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:237:

Met Glu Lys Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile Pro Ala Ser

1 5 10 15

Thr Gin Lys Leu Tyr Leu Ser Pro Val Leu Asp Gly Phe Asn Ser Glu 20 25 30 Ile Ile Ala Tyr Asn Leu Ser Thr Ser Pro Asn Leu Glu Gin Val Gin

35 40 45

Thr Met Leu Glu Gin Ala Phe Thr Glu Lys His Tyr Glu Asn Thr Ile

50 55 60

Leu His Ser Asp Gin Gly Trp Gin Tyr Gin His Asp Ser Tyr His Arg 65 70 75 80

Phe Leu Arg Val Arg Glu Phe Lys His Leu Cys His Ala Arg Glu Thr

85 90 95

Ala Lys Thr Thr Val 100

(2) INFORMATION FOR SEQ ID NO:238:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 94 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:238:

Met Glu Ile Leu Thr Thr Gin Gin Val Arg Glu Gly Tyr Gin Ala Ile

1 5 10 15

Leu Ala Ser Pro Leu Gly Leu Gin Asp Ala Phe Glu Val Ala Gin Glu

20 25 30

Lys Ser Gly Ser Tyr Thr Val Pro Pro Glu Ile Asp Gly Trp Lys Gly

35 40 45

Asn Thr Glu Pro Leu Arg Ile Asp Tyr Val Phe Thr Thr Lys Glu Leu

50 55 60

Ala Val Glu Asn Leu His Val Val Phe Asp Gly Asn Lys Ser Pro Gin 65 70 75 80

Val Ser Asp His Tyr Gly Leu Asn Ala Met Leu Asn Trp Lys 85 90

(2) INFORMATION FOR SEQ ID NO:239:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 142 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:239:

Met Leu Lys His Leu Asn Leu Lys Gly His Leu Leu Thr Ala Ile Ser

1 5 10 15

Tyr Met Ile Pro Ile Val Cys Gly Ala Gly Phe Leu Val Ala Ile Gly

20 25 30

Leu Ala Met Gly Gly Gly Val Pro Asp Ala Leu Val Ala Gly Lyε Phe

35 40 45

Thr Ile Trp Asp Ala Leu Ala Thr Met Gly Gly Lys Ala Leu Gly Leu

50 55 60

Leu Pro Val Val Ile Ala Thr Gly Leu Ser Tyr Ser Ile Ala Gly Lys 65 70 75 80

Pro Gly Ile Ala Pro Gly Phe Val Val Gly Leu Ile Ala Asn Ser Val

85 90 95

Gly Ser Gly Phe Ile Gly Gly Ile Leu Gly Gly Tyr Ile Val Gly Phe

100 105 110

Leu Val Gin Ala Ile Ile Lys Lys Val Lys Val Pro Asn Trp Ile Lys

115 120 125

Gly Leu Met Pro Thr Leu Ile Ile Pro Phe Val Pro Leu Trp 130 135 140

(2) INFORMATION FOR SEQ ID NO:240:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 212 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:240:

Met Ile Ala Leu Gly Trp Ser Asn Ile Gly Ala Ala Ile Ala Pro Asp

1 5 10 15

Ala Ala Leu Ala Ser Val Ala Ala Ala Ile Ile Met Val Leu Gly Gly

20 25 30

Asp Phe Thr Lys Thr Gly Ile Gly Val Ala Gin Ala Val Ala Ile Pro

35 40 45

Leu Ala Val Ala Gly Leu Phe Leu Thr Met Ile Val Arg Thr Ile Ser 50 55 60 Val Gly Leu Val His Thr Ala Asp Ala Ala Ala Lys Lys Gly Asp Phe 65 70 75 80

Gly Ala Val Glu Arg Ala His Phe Ile Ala Leu Leu Phe Gin Gly Leu

85 90 95

Arg Ile Ala Leu Pro Ala Ala Leu Leu Leu Met Val Pro Thr Glu Thr

100 105 110

Val Gin Ser Ile Leu Ser Ala Met Pro Asp Trp Leu Lys Asp Gly Met

115 120 125

Ala Ile Gly Gly Gly Met Val Val Ala Val Gly Tyr Ala Met Val Ile

130 135 140

Asn Met Met Ala Thr Arg Glu Val Trp Pro Phe Phe Ala Leu Gly Phe 145 150 155 160

Val Leu Ala Ala Val Ser Asp Ile Thr Leu Ile Gly Phe Gly Ala Ile

165 170 175

Gly Val Ala Ile Ala Leu Ile Tyr Leu His Leu Ser Lys Thr Gly Gly

180 185 190

Asn Gly Gly Gly Gly Ala Ala Thr Ser Asn Asp Pro Ile Gly Asp Ile

195 200 205

Leu Glu Asp Tyr 210

(2) INFORMATION FOR SEQ ID NO:241:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:241:

Met Leu Asp Val Glu Ala Ile Arg Lys Asp Phe Pro Ile Leu Asp Gin

1 5 10 15

Ile Val Asn Asp Glu Pro Leu Val Tyr Leu Asp Asn Ala Ala Thr Thr

20 25 30

Gin Lys Pro Leu Val Val Leu Lys Ala Ile Asn Ser Tyr Tyr Glu Gin

35 40 45

Asp Asn Ala Asn Val His Arg Gly Val His Thr Leu Ala Glu Arg Ala

50 55 60

Thr Ala Ser Leu 65 (2) INFORMATION FOR SEQ ID NO:242:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:242:

Met Thr Lys Leu Leu Asn Lys Lys Trp Lys Val Lys Ile Met Lys Gin

1 5 10 15

Ile Leu Leu Val Cys Asn Ala Gly Met Ser Thr Ser Met Leu Val Lys

20 25 30

Lys Met Gin Gin Ser Ala Thr Glu Arg Gly Ile Glu Ile Ser Ile Gin

35 40 45

Ala Lys Ser Met Thr Glu Ala Lys Lys Asn Ile His Glu Ala Asp Val

50 55 60

Ile Leu Ile Gly Pro Gin Ile Arg Tyr Glu Leu Leu Ala Val Lys Glu 65 70 75 80

Ile Ala Gly Asn Ile Pro Val Asp Thr Ile Asp Met Arg Asp Tyr Gly

85 90 95

Met Met Asn Gly Ala Lys Val Leu Glu Gin Ala Leu Glu Trp Ile Gly

100 105 110

Glu Ile Arg 115

(2) INFORMATION FOR SEQ ID NO:243:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 99 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:243:

Met Val Leu Met Gin Lys Met His Gly Lys Glu Leu Ile Thr Leu Asn

1 5 10 15 Gin Thr Val Lys Trp Tyr Lys Val Ser Gly Phe Met Ile Leu Leu Thr

20 25 30

Lys Pro Trp Tyr Tyr Leu Lys Ser Asp Gly Ser Tyr Ala Arg Asn Ala

35 40 45

Trp Gin Gly Asn Tyr Tyr Leu Lys Ser Asp Gly Lys Met Ala Val Asn

50 55 60

Glu Trp Val Tyr Asp Ala Thr Tyr Gin Ala Trp Tyr Tyr Leu Thr Ser 65 70 75 80

Asp Gly Ser Tyr Ala Tyr Ser Thr Trp Gin Gly Asn Tyr Tyr Pro Lys

85 90 95

Ile Gly Trp

(2) INFORMATION FOR SEQ ID NO:244:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 65 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:244:

Met Leu Thr Val His Gly Lys Glu Ile Thr Ile Leu Lys Ser Asp Gly

1 5 10 15

Lys Met Ala Val Asn Glu Trp Val Asp Gly Gly Arg Tyr Tyr Val Gly

20 25 30

Ala Asp Gly Val Trp Lys Glu Gly Gin Ala Ser Thr Ala Ser Pro Ser

35 40 45

Asn Asp Ser Asn Ser Glu Tyr Ser Cys Cys Phe Arg Lys Gly Lys Lys

50 55 60

Leu 65

(2) INFORMATION FOR SEQ ID NO:245:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 225 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:245:

Met Asn Asn Asn Phe Asn Asn Phe Aεn Aεn Met Aεp Asp Leu Phe Asn

1 5 10 15

Gin Leu Met Gly Gly Met Arg Gly Tyr Ser Ser Glu Asn Arg Arg Tyr

20 25 30

Leu Ile Asn Gly Arg Glu Val Thr Pro Glu Glu Phe Ala His Tyr Arg

35 40 45

Thr Thr Gly Gin Leu Pro Gly Asn Ala Glu Thr Asp Val Gin Met Pro

50 55 60

Gin Gin Ala Ser Gly Met Lys Gin Asp Gly Val Leu Ala Lys Leu Gly 65 70 75 80

Arg Asn Leu Thr Ala Glu Ala Arg Glu Gly Lys Leu Asp Pro Val Ile

85 90 95

Gly Arg Asn Lys Glu Ile Gin Glu Thr Ser Glu Ile Leu Ser Arg Arg

100 105 110

Thr Lys Asn Asn Pro Val Leu Val Gly Asp Ala Gly Val Gly Lys Thr

115 120 125

Ala Val Val Glu Gly Leu Ala Gin Ala Ile Val Asn Gly Asp Val Pro

130 135 140

Ala Ala Ile Lys Asn Lys Glu Ile Ile Ser Ile Asp lie Ser Gly Leu 145 150 155 160

Glu Ala Gly Thr Gin Tyr Arg Gly Ser Phe Glu Glu Asn Val Gin Asn

165 170 175

Leu Val Asn Glu Val Lys Glu Ala Gly Asn Ile Ile Leu Phe Phe Asp

180 185 190

Glu Ile His Gin Ile Leu Gly Ala Gly Ser Thr Cys Gly Asp Ser Gly

195 200 205

Ser Lys Gly Leu Ala Asp Ile Leu Ser Gin Ser Ile Ser Leu Val Glu

210 215 220

Asn 225

(2) INFORMATION FOR SEQ ID NO:246:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 148 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246:

Met Thr Ile Phe Pro Asp Asp Phe Leu Trp Gly Gly Ala Val Ala Ala

1 5 10 15

Asn Gin Val Glu Gly Ala Tyr Asn Glu Asp Gly Lys Gly Leu Ser Val

20 25 30

Gin Asp Val Leu Pro Lys Gly Gly Leu Gly Glu Ala Thr Glu Asn Pro

35 40 45

Thr Glu Asp Asn Leu Lys Leu lie Gly Ile Asp Phe Tyr His Lys Tyr

50 55 60

Lys Glu Asp Ile Ser Leu Phe Ser Glu Met Gly Phe Asn Val Phe Arg 65 70 75 80

Thr Ser Ile Ala Trp Ser Arg Ile Phe Pro Lys Gly Asp Glu Glu Glu

85 90 95

Pro Asn Glu Ala Gly Leu Lys Tyr Tyr Asp Glu Leu Phe Asp Glu Leu

100 105 110

His Ala Hiε Gly Ile Glu Pro Leu Val Thr Leu Ser Hiε Tyr Glu Thr

115 120 125

Pro Leu Tyr Leu Ala Arg Lys Tyr His Gly Trp Ile Asp Arg Lys Asn

130 135 140

Asp Ser Phe Leu 145

(2) INFORMATION FOR SEQ ID NO:247:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 242 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:247:

Met Ile Glu Tyr Lys Asn Val Ala Leu Arg Tyr Thr Glu Lys Asp Val

1 5 10 15

Leu Arg Asp Val Asn Leu Gin Ile Glu Asp Gly Glu Phe Met Val Leu

20 25 30

Val Gly Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Lys Met Ile Asn

35 40 45

Arg Leu Leu Glu Pro Thr Asp Gly Asn Ile Tyr Met Asp Gly Lys Arg 50 55 60 Ile Lys Asp Tyr Asp Glu Arg Glu Leu Arg Leu Ser Thr Gly Tyr Val 65 70 75 80

Leu Gin Ala Ile Ala Leu Phe Pro Asn Leu Thr Val Ala Glu Asn Ile

85 90 95

Ala Leu Ile Pro Glu Met Lys Gly Trp Ser Lys Glu Glu Ile Thr Lys

100 105 110

Lyε Thr Glu Glu Leu Leu Ala Lys Val Gly Leu Pro Val Ala Glu Tyr

115 120 125

Gly His Arg Leu Pro Ser Glu Leu Ser Gly Gly Glu Gin Gin Arg Val

130 135 140

Gly Ile Val Arg Ala Met Ile Gly Gin Pro Lys Ile Phe Leu Met Asp 145 150 155 160

Glu Pro Phe Ser Ala Leu Asp Ala Ile Ser Arg Lys Gin Leu Gin Val

165 170 175

Leu Thr Lys Glu Leu His Lys Glu Phe Gly Met Thr Thr Ile Phe Val

180 185 190

Thr His Asp Thr Asp Glu Ala Leu Lys Leu Ala Asp Arg Ile Ala Val

195 200 205

Leu Gin Asp Gly Glu Ile Arg Gin Val Ala Asn Pro Glu Thr Ile Leu

210 215 220

Lys Val Pro Ala Thr Asp Phe Val Ala Asp Leu Phe Gly Gly Ser Val 225 230 235 240

His Asp

(2) INFORMATION FOR SEQ ID NO:248:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:248:

Met Pro Phe Val Pro Gly Ile Ala Leu Thr Asn Ala Val Arg Asp Ile

1 5 10 15

Met Thr Asn His Ile Asn Ser Gly Met Ser Lys Met Phe Glu Ser Leu

20 25 30

Leu Ile Thr Leu Ala Leu Gly Ala Gly Thr Ser Val Ala Leu Val Leu 35 40 45 Met Asn 50

(2) INFORMATION FOR SEQ ID NO:249:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:249:

Met Tyr Thr Ile Arg Met Leu Lys Met Gly Ser Glu Ala Ala Ala Lys

1 5 10 15

Ser Ala Gin Glu His Gly Leu Lys Ser Val Glu Val Thr Val Lys Gly

20 25 30

Pro Gly Ser Gly Arg Glu Ser Ala Ile Ser Cys Ala Cys Cys Arg Trp

35 40 45

Ser

(2) INFORMATION FOR SEQ ID NO:250:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 311 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:250:

Met Ile Glu Phe Glu Lys Pro Asn Ile Thr Lys Ile Asp Glu Asn Lys

1 5 10 15

Asp Tyr Gly Lys Leu Val Ile Glu Pro Leu Glu Arg Gly Tyr Gly Thr

20 25 30

Ala Leu Gly Asn Ser Leu Arg Arg Val Leu Leu Ala Ser Leu Pro Gly

35 40 45

Ala Ala Val Thr Ser Ile Asn Ile Asp Gly Val Leu His Glu Phe Asp 50 55 60 Thr Val Pro Gly Val Arg Glu Asp Val Met Gin Ile Ile Leu Asn Ile 65 70 75 80

Lys Gly Ile Ala Val Lys Ser Tyr Val Glu Asp Glu Lys Ile Ile Glu

85 90 95

Leu Asp Val Glu Gly Pro Ala Glu Val Thr Ala Gly Asp Ile Leu Thr

100 105 110

Asp Ser Asp Ile Glu Ile Val Asn Pro Asp His Tyr Leu Phe Thr Ile

115 120 125

Gly Glu Gly Ser Ser Leu Lys Ala Thr Met Thr Val Asn Ser Gly Arg

130 135 140

Gly Tyr Val Pro Ala Asp Glu Asn Lys Lys Asp Asn Ala Pro Val Gly 145 .150 155 160

Thr Leu Ala Val Asp Ser Ile Tyr Thr Pro Val Thr Lys Val Asn Tyr

165 170 175

Gin Val Glu Pro Ala Arg Val Gly Ser Asn Asp Gly Phe Asp Lys Leu

180 185 190

Thr Leu Glu Ile Leu Thr Asn Gly Thr Ile Ile Pro Glu Asp Ala Leu

195 200 205

Gly Leu Ser Ala Arg Ile Leu Thr Glu His Leu Asp Leu Phe Thr Asn

210 215 220

Leu Thr Glu Ile Ala Lys Ser Thr Glu Val Met Lys Glu Ala Asp Thr 225 230 235 240

Glu Ser Asp Asp Arg Ile Leu Asp Arg Thr Ile Glu Glu Leu Asp Leu

245 250 255

Ser Val Arg Ser Tyr Asn Cys Leu Lys Arg Ala Gly Ile Asn Thr Val

260 265 270

His Asp Leu Thr Glu Lys Ser Glu Ala Glu Met Met Lys Val Arg Asn

275 280 285

Leu Gly Arg Lys Ser Leu Glu Glu Val Lys Leu Lys Leu Ile Asp Leu

290 295 300

Gly Leu Gly Leu Lys Asp Lys 305 310

(2) INFORMATION FOR SEQ ID NO:251:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 151 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:251: Met Asp Ile Glu Lys Gin Arg Gly Ile Ser Val Thr Ser Ser Val Met

1 5 10 15

Gin Phe Asp Tyr Asp Gly Lys Arg Val Aεn Ile Leu Aεp Thr Pro Gly

20 25 30

His Glu Asp Phe Ser Glu Asp Thr Tyr Arg Thr Leu Met Ala Val Asp

35 40 45

Ala Ala Val Met Val Val Asp Ser Ala Lys Gly Ile Glu Ala Gin Thr

50 55 60

Lys Lys Leu Phe Glu Val Val Lys His Arg Gly Ile Pro Val Phe Thr 65 70 75 80

Phe Met Asn Lyε Leu Asp Arg Asp Gly Arg Glu Pro Leu Asp Leu Leu

85 90 95

Gin Glu Leu Glu Glu Ile Leu Gly Ile Ala Ser Tyr Pro Met Asn Trp

100 105 110

Pro Ile Gly Met Gly Lys Ala Phe Glu Gly Leu Tyr Asp Leu Tyr Asn

115 120 125

Gin Arg Leu Glu Leu Tyr Lys Gly Asp Glu Arg Phe Ala Ser Pro Arg

130 135 140

Arg Trp Arg Gin Thr Phe Trp 145 150

(2) INFORMATION FOR SEQ ID NO:252:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:252:

Met Ala Val Ile Ala Glu Arg Lys Ala Tyr Tyr His Asp Pro Val Glu

1 5 10 15

Asp Ala Ile Ile Met Lys Arg Glu Ile Asp Glu Gly 20 25

(2) INFORMATION FOR SEQ ID NO:253:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 149 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:253:

Met Asn Glu Thr Trp Ser Arg Thr Ala Leu Thr Leu Leu Lys His Gly

1 5 10 15

Ser Glu Val Asn Leu Glu Arg Ala Leu Ser Val Asn Gly Arg Leu Gly

20 25 30

Gly His Val Val Thr Gly His Ile Asp Gly Thr Gly Lys Ile Ser Ser

35 40 45

Ile Lys Lys Asp Aεp Asn Ala Val Trp Tyr Gin Ile Asn Thr Gin Lys

50 55 60

Glu Ile Leu Asp Leu Ile Val Glu Lys Gly Ser Ile Thr Ile Asp Gly 65 70 75 80

Ile Ser Leu Thr Val Ala Lys Val Ser Lys Val Asn Phe Ser Val Ser

85 90 95

Val Ile Pro His Thr Leu Lys Gin Thr Ile Leu Lys Ser Lys Gin Val

100 105 110

Gly Ser Thr Val Asn Leu Glu Asn Asp Ile Leu Gly Lys Tyr Val Gin

115 120 125

Lys Leu Met Asp Asn Ser Pro Lys Ser Glu Ile Ser Lys Glu Leu Leu

130 135 140

Tyr Gin Asn Gly Phe 145

(2) INFORMATION FOR SEQ ID NO:254:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: εingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 254:

Met Asn Trp Ser Ala Leu Glu Gin Gin Ile Val Asp Glu Leu Lys Ile

1 5 10 15

Tyr Ile Ala Pro Lys Ile Phe Gly Gly Ser Ala Lys Phe Pro Val Gly 20 25 30 Gly Glu Gly Ile Ser Leu Pro Asn Asp Ala Ile Arg Leu Lys Pro Tyr

35 40 45

Ala Phe Ser Gin Xaa Gly Xaa Asp Tyr Leu Ile Glu Ser Glu Val Ile

50 55 60

Tyr Pro Cys Ser Gin Glu 65 70

(2) INFORMATION FOR SEQ ID NO:255:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 113 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:255:

Met Val Leu Phe Leu Val Pro Gin Leu Arg Asn Ala Tyr Gly Thr Ala

1 5 10 15

Ala Ile Gly Ile Ile Cys Gly Leu Tyr Trp Ala Val Ser Ser Asn Met

20 25 30

Thr Val Glu Ala Thr Gin Arg Leu Thr Gly Gly Gly Gly Phe Ala Ile

35 40 45

Gly His Gin Gin Gin Phe Ala Ile Trp Phe Val Asp Lys Val Ala Gly

50 55 60

Arg Phe Gly Lys Lys Glu Glu Ser Leu Asp Asn Leu Lys Leu Pro Lys 65 70 75 80

Phe Leu Ser Ile Phe His Asp Thr Val Val Ala Ser Ala Thr Phe Asp

85 90 95

Ala Arg Ile Leu Arg Gly His Ser Phe Asn Leu Gly Ser Arg His Tyr

100 105 110

Val

(2) INFORMATION FOR SEQ ID NO:256:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:256:

Met Leu Ile Asn Ser Leu Asn Gin Ser Tyr Ile Ser Ala Lys Arg Ile

1 5 10 15

Glu Glu Val Phe Ala Glu Ser Pro Glu Asn Ile His Ser Glu Leu Glu

20 25 30

Gin Lys Gin Val Thr Ser Gly Arg Val Leu Gin Val Gin Glu Leu Thr

35 40 45

Phe Thr Tyr Pro Asp Ala Ala Gin Pro Ser Leu Arg Asp Ile Ser Phe

50 55 60

Asp Met Thr Gin Gly Gin Ile Leu Gly Ile Ile Gly Gly Thr Gly Ser 65 70 75 80

Gly Lys Ser Ser Leu Val Gin Leu Leu Leu Gly Leu Tyr Pro Val Asp

85 90 95

Lys Gly Asn Ile Asp Leu Tyr Gin Asn Gly Arg Ser Pro Leu Asn Leu

100 105 110

Glu Gin Trp Arg Ser Trp Ile Ala Tyr Val Pro Gin Lys Val Lys Leu

115 120 125

Phe Lys Gly Thr Ile Arg Ser Asn Leu Thr Leu Gly Leu Asn Gin Glu

130 135 140

Val Ser Asp Gin Lys Leu Trp Gin Ala Leu Glu Ile Ala Gin Ala Lys 145 150 155 160

Asp Phe Val Ser Glu Lys Glu Gly Leu Leu Asp Ala Leu Ile Glu Ala

165 170 175

Gly Gly Arg Asn Phe Ser Gly Gly Gin Lys Gin Arg Leu Ser Ile Ala

180 185 190

Arg Ala Val Leu Arg Gin Ala Pro Phe Ile Ile Leu Asp Asp Ala Thr

195 200 205

Ser Ala Leu Asp Thr Ile Thr Glu Ser Lys Leu Leu Lys Ala Ile Arg

210 215 220

Glu Asn Phe Pro Asn Thr Ser Leu Ile Leu Ile Ser Gin Arg Thr Ser 225 230 235 240

Thr Leu Gin Met Ala Asp Gin Ile Leu Leu Leu Glu Lys Gly Glu Leu

245 250 255

Leu Ala Val Gly Lys His Asp Asp Leu Met Lys Ser Ser Gin Val Tyr

260 265 270

Arg Glu Ile Asn Ala Ser Gin Hiε Gly Lys Glu Asp 275 280

(2) INFORMATION FOR SEQ ID NO:257:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH : 105 amino acids

(B) TYPE : amino acid

(C) STRANDEDNESS : single

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:257:

Met Lys Asp Pro Glu Ser Arg Leu Tyr Ile Leu Leu Lys Asp Gly Gin

1 5 10 15

Val Ile Gly Thr Cys Thr Val Asp Leu Ser Thr Asn Thr Asn Tyr Phe

20 25 30

Tyr Gly Leu Ala Ile Leu Glu Pro Glu Arg Gly Lys Gly Tyr Gly Ser

35 40 45

Tyr Leu Ala Lys Ser Leu Val Asn Gin Leu lie Glu Gin Asn Asp Lys

50 55 60

Glu Phe Gin Ile Ala Val Glu Asp Ser Asn Val Gly Ala Lys Arg Leu 65 70 75 80

Tyr Glu Lys Ile Gly Phe Val Lys Gin Thr Gin Val Val Tyr Leu Asn

85 90 95

Glu Lys Gly Ala Arg Asp Ser Glu Val 100 105

(2) INFORMATION FOR SEQ ID NO:258:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:258:

Met Phe Ala Leu Ser Ser Asn Lys Glu Leu Ala Glu Arg Val Ala Gin

1 5 10 15

Glu Ile Gly Ile Glu Leu Gly Lys Ser Ser Val Arg Gin Phe Ser Asp

20 25 30

Gly Glu Ile Gin Val Asn Ile Glu Glu Ser Ile Arg Gly Lys His Val

35 40 45

Phe Ile Leu Gin Ser Thr Ser Ser Pro Val Asn Asp Asn Leu Leu Glu 50 55 60 Ile Leu Ile Met Val Asp Ala Leu Lys Arg Ala Ser Ala Glu Ser Val 65 70 75 80

Asn Val Val Met Pro Tyr Tyr Gly Tyr Ala Arg Gin Asp Arg Lys Ala

85 90 95

Arg Ala Arg Glu Pro Ile Thr Ser Lys Leu Val Ala Asn Met Leu Glu

100 105 110

Val Ala Gly Val Asp Arg Leu Leu Thr Ile Asp Leu His Ala Ala Gin

115 120 125

Ile Gin Gly Phe Phe Asp Ile Pro Val Asp His Leu Met Gly Ala Pro

130 135 140

Leu Ile Ala Asp Tyr Phe Glu Arg Pro Gly Met Val Gly Ser Asp Tyr 145 150 155 160

Val Val Val Ser Pro Asp His Gly Gly Val Thr Arg Ala Arg Lys Leu

165 170 175

Ala Glu Phe Leu Lys Thr Ser Ile Ala Ile Ile Glu Lys Arg Arg Ser

180 185 190

Val Asp Lys Met Asn Thr Ser Glu Val Met Asn Thr Ile Gly Lys Val

195 200 205

Glu Gly Asn His Leu 210

(2) INFORMATION FOR SEQ ID NO:259:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 182 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:259:

Met Ile Ser Phe Leu Leu Leu Leu Val Leu Val Trp Gly Phe Tyr Ile

1 5 10 15

Gly Tyr Arg Arg Gly Leu Leu Leu Gin Val Tyr Tyr Leu Ile Ser Ala

20 25 30

Met Ala Ser Ala Phe Met Ala Gly Gin Phe Tyr Lys Gly Leu Gly Glu

35 40 45

Gin Phe His Leu Leu Leu Pro Tyr Ala Asn Ser Gin Glu Gly Gin Gly

50 55 60

Thr Phe Phe Phe Pro Ser Asp Gin Leu Phe Gin Leu Asp Lys Val Phe 65 70 75 80 Tyr Ala Gly Ile Gly Tyr Leu Leu Val Phe Gly Ile Val Tyr Ser Ile

85 90 95

Gly Arg Leu Leu Gly Leu Leu Leu His Leu Ile Pro Ser Lys Lys Leu

100 105 110

Gly Gly Lys Leu Phe Gin Val Ser Ala Gly Ile Leu Ser Met Leu Val

115 120 125

Thr Leu Phe Val Leu Gin Met Ala Leu Thr Ile Leu Ala Thr Ile Pro

130 135 140

Met Ala Val Ile Gin Asn Pro Leu Glu Lys Ser Ile Val Ala Lys His 145 150 155 160

Ile Ile Gin Ser lie Pro Ile Thr Thr Ser Trp Leu Lys Gin Ile Trp

165 170 175

Val Thr Asn Leu Ile Gly 180

(2) INFORMATION FOR SEQ ID NO:260:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 160 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:260:

Met Arg Ala Phe Ser Asp Phe Gly Thr Pro Met Leu Ile Gly Glu Gly

1 5 10 15

Tyr Arg Thr Phe Pro Val Leu Ile Tyr Thr Gin Phe Ile Ser Glu Val

20 25 30

Gly Gly Asn Ser Ala Phe Ala Ile Met Ala Ile Ile Ile Ala Leu Ala

35 40 45

Ile Phe Leu lie Gin Lys His Ile Ala Asn Arg Tyr Ser Phe Ser Met

50 55 60

Asn Leu Leu His Pro Ile Glu Pro Lys Lys Thr Thr Lys Gly Lys Met 65 70 75 80

Ala Ala Ile Tyr Ala Thr Val Tyr Gly Ile Ile Phe Ile Ser Val Leu

85 90 95

Pro Gin Ile Tyr Leu Ile Tyr Thr Ser Phe Leu Lys Thr Ser Gly Met

100 105 110

Val Phe Val Lys Gly Tyr Ser Pro Asn Ser Tyr Lys Val Ala Phe Asn 115 120 125 Arg Met Gly Ser Ala Ile Phe Asn Thr Ile Arg Ile Pro Leu Ile Ala

130 135 140

Leu Val Leu Val Val Pro Ile Tyr Asp Ile Tyr Leu Leu Pro Ser Arg

145 150 155 160

(2) INFORMATION FOR SEQ ID NO:261:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 74 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:261:

Met Val Pro Tyr Ile Val Pro Gly Thr Val Leu Gly lie Ala Phe Ile

1 5 10 15

Ser Ser Phe Asn Thr Gly Leu Phe Gly Ser Gly Phe Leu Met Ile Thr

20 25 30

Gly Thr Ala Phe Ile Leu Ile Met Ser Leu Ser Val Arg Arg Leu Pro

35 40 45

Tyr Thr Ile Arg Ser Ser Val Ala Ser Leu Gin Gin Ile Ala Pro Ser

50 55 60

Ile Glu Glu Ala Ala Gly Lys Leu Arg Lys 65 70

(2) INFORMATION FOR SEQ ID NO:262:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:262:

Met Ile Phe Ile Pro Met Ala Ala Tyr Ser Ile Ala Arg Asn Met Ser

1 5 10 15

Lys Arg Lys Ala Phe Thr Ile His Val Tyr Pro Leu Asn Pro Arg Asn 20 25 30 Leu Arg Thr Phe Pro Ser His His Asp Ser Asp Tyr Gly Tyr Asp Glu 35 40 45

(2) INFORMATION FOR SEQ ID NO:263:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 71 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:263:

Met Lys Phe Arg Lys Leu Ala Cys Thr Val Leu Ala Gly Ala Ala Val

1 5 10 15

Leu Gly Leu Ala Ala Cys Gly Asn Ser Gly Gly Ser Lys Asp Ala Ala

20 25 30

Lys Ser Gly Gly Asp Gly Ala Lys Thr Glu Ile Thr Trp Trp Ala Phe

35 40 45

Pro Val Phe Thr Gin Glu Lys Thr Gly Asp Gly Val Gly Thr Tyr Glu

50 55 60

Lys Ser Ile Ile Gin Ala Phe 65 70

(2) INFORMATION FOR SEQ ID NO:264:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 275 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:264:

Met Asn Ser Gin Gin Lys Pro Gin Glu Ile Lys Val Glu Glu Pro Val

1 5 10 15

Glu Ser Lys Glu Glu Thr Val Asn Gin Pro Val Glu Gin Pro Lys Val

20 25 30

Glu Thr Pro Ala Val Glu Lys Gin Thr Glu Pro Thr Glu Glu Pro Lys 35 40 45 Val Glu Val Thr Ser Ile Pro Gin Thr Thr Arg Tyr Glu Glu Asp Leu

50 55 60

Thr Lys Glu His Gly Thr Arg Glu Val Val Lys Glu Gly Lys Asn Gly 65 70 75 80

Ser Arg Thr Val Thr Thr Pro Tyr Ile Leu Asn Ala Thr Asp Gly Thr

85 90 95

Thr Thr Glu Gly Thr Ser Thr Thr Asp Glu Ala Glu Met Glu Lys Glu

100 105 110

Val Val Arg Val Gly Thr Lys Pro Lys Glu Lys Leu Ala Pro Val Leu

115 120 125

Ser Leu Thr Ser Val Thr Asp Asn Ala Met Leu Arg Ser Ala Arg Leu

130 135 140

Thr Tyr His Leu Glu Asn Thr Asp Ser Val Asp Val Lys Lys Ile His 145 150 155 160

Ala Glu Ile Lys Asn Gly Asp Lys Val Val Lys Thr Ile Asp Leu Ser

165 170 175

Lys Glu Arg Leu Ser Asp Ala Val Asp Gly Leu Glu Leu Tyr Lys Asp

180 185 190

Tyr Lys Ile Val Thr Ser Met Thr Tyr Aεp Arg Gly Asn Gly Glu Glu

195 200 205

Thr Ser Thr Leu Glu Glu Thr Pro Leu Arg Leu Asp Leu Lys Lys Val

210 215 220

Glu Leu Lys Asn Ile Gly Ser Thr Asn Leu Val Lys Val Asn Glu Asp 225 230 235 240

Gly Thr Glu Val Ala Ser Asp Phe Leu Thr Ser Lys Pro Val Asp Val

245 250 255

Gin Asn Tyr Tyr Leu Lys Val Thr Ser Arg Asp Asn Lys Val Val Ser

260 265 270

Pro Pro Ser 275

(2) INFORMATION FOR SEQ ID NO:265:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 106 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:265: Met Ala Val Met Lys Ile Glu Tyr Tyr Ser Gin Val Leu Asp Met Glu

1 5 10 15

Trp Gly Val Asn Val Leu Tyr Pro Asp Ala Asn Arg Val Glu Glu Pro

20 25 30

Glu Cys Glu Asp Ile Pro Val Leu Tyr Leu Leu His Gly Met Ser Gly

35 40 45

Asn His Asn Ser Trp Leu Lys Arg Thr Asn Val Glu Arg Leu Leu Arg

50 55 60

Gly Thr Asn Leu Ile Val Val Met Pro Asn Thr Ser Asn Gly Trp Tyr 65 70 75 80

Thr Asp Thr Gin Tyr Gly Phe Asp Tyr Tyr Thr Ala Leu Ala Glu Glu

85 90 95

Leu Pro Gin Val Pro Glu Thr Leu Leu Pro 100 105

(2) INFORMATION FOR SEQ ID NO:266:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 51 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:266:

Met Arg Leu Leu Ala Met Lys Met Lys Gin Ile Ser Asp Thr Thr Leu

1 5 10 15

Lyε lie Thr Met Ser Leu Glu Asp Leu Met Asp Arg Gly Met Glu Ile

20 25 30

Ala Asp Phe Leu Val Pro Gin Glu Lys Thr Glu Glu Phe Phe Tyr Ala

35 40 45

Ile Leu Gly 50

(2) INFORMATION FOR SEQ ID NO:267:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 131 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:267:

Met Leu Pro Ile Ile Cys Cys Gly Glu Ser Leu Glu Thr Tyr Glu Ala

1 5 10 15

Gly Lys Ala Ala Glu Phe Val Gly Ala Gin Val Ser Ala Ala Leu Ala

20 25 30

Gly Leu Thr Ala Glu Gin Val Ala Ala Ser Val Ile Ala Tyr Glu Pro

35 40 45

Ile Trp Ala Ile Gly Thr Gly Lys Ser Ala Ser Gin Asp Asp Ala Gin

50 55 60

Lys Met Cys Lys Val Val Arg Asp Val Val Ala Ala Asp Phe Gly Gin 65 70 75 80

Glu Val Ala Asp Lys Val Arg Val Gin Tyr Gly Gly Ser Val Lys Pro

85 90 95

Glu Asn Val Ala Ser Tyr Met Ala Cys Pro Asp Val Asp Gly Ala Leu

100 105 110

Val Gly Gly Ala Ser Leu Glu Ala Glu Ser Phe Leu Ala Leu Leu Asp

115 120 125

Phe Val Lys 130

(2) INFORMATION FOR SEQ ID NO:268:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 208 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:268:

Met Phe Val Glu Ala Cys Lys Ala Val Val Arg Ala Asn Glu Glu Tyr

1 5 10 15

Val Pro Pro Tyr Gly Ile Gly Gly Thr Leu Tyr Leu Arg Pro Leu Leu

20 25 30

Ile Gly Val Gly Asp Ile Ile Gly Val Lys Pro Ala Glu Glu Tyr Ile

35 40 45

Phe Thr Ile Phe Ala Met Pro Val Gly Asn Tyr Phe Lys Gly Gly Leu 50 55 60 Val Pro Thr Asn Phe Leu Ile Gin Asp Glu Tyr Asp Arg Ala Ala Pro 65 70 75 80

Asn Gly Thr Gly Ala Ala Lys Val Gly Gly Asn Tyr Ala Ala Ser Leu

85 90 95

Leu Pro Gly Lys Met Ala Lys Ser Arg His Phe Ser Asp Val Ile Tyr

100 105 110

Leu Asp Pro Ser Thr His Thr Lys Ile Glu Glu Val Gly Ser Ala Asn

115 120 125

Phe Phe Gly Ile Thr Ala Asp Asn Glu Phe Val Thr Pro Leu Ser Pro

130 135 140

Ser Ile Leu Pro Ser Ile Thr Lys Tyr Ser Leu Leu Tyr Leu Ala Glu 145 150 155 160

His Arg Leu Gly Leu Thr Pro Ile Glu Gly Asp Val Pro Ile Asp Asn

165 170 175

Leu Asp Arg Phe Val Lys Ala Gly Ala Cys Gly Thr Ala Ala Val Ile

180 185 190

Ser Pro Ile Gly Gly Ile Gin His Gly Asp Asp Phe His Val Ile Leu 195 200 205

(2) INFORMATION FOR SEQ ID NO:269:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:269:

Met Val Met Ile Ser Met Leu Phe Tyr Ser Glu Thr Glu Val Gly Pro

1 5 10 15

Val Thr Arg Lys Leu Tyr Asn Glu Leu Thr Gly Ile Gin Phe Gly Asp

20 25 30

Ile Glu Ala Pro Glu Gly Trp Ile Val Lys Val Asp 35 40

(2) INFORMATION FOR SEQ ID NO:270:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 248 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:270:

Met Thr Ala Ser Pro Leu Lys Lys Ser Ile Lys Lys Lys Asn Arg Lyε

1 5 10 15

Leu Thr Asn Lys Xaa Glu Lys His Met Ser Lys Ile lie Gly Ile Asp

20 25 30

Leu Gly Thr Thr Asn Ser Ala Val Ala Val Leu Glu Gly Thr Glu Ser

35 40 45

Lys Ile Ile Ala Asn Pro Glu Gly Asn Arg Thr Thr Pro Ser Val Val

50 55 60

Ser Phe Lys Asn Gly Glu Ile Ile Val Gly Asp Ala Ala Lys Arg Gin 65 70 75 80

Ala Val Thr Asn Pro Asp Thr Val Ile Ser Ile Lys Ser Lys Met Gly

85 90 95

Thr Ser Glu Lys Val Ser Ala Asn Gly Lys Glu Tyr Thr Pro Gin Glu

100 105 110

Ile Ser Ala Met Ile Leu Gin Tyr Leu Lys Gly Tyr Ala Glu Asp Tyr

115 120 125

Leu Gly Glu Lys Val Thr Lys Ala Val Ile Thr Val Pro Ala Tyr Phe

130 135 140

Asn Asp Ala Gin Arg Gin Ala Thr Lys Asp Ala Gly Lys Ile Ala Gly 145 150 155 160

Leu Glu Val Xaa Arg Ile Val Asn Glu Pro Thr Ala Ala Ala Leu Ala

165 170 175

Tyr Gly Leu Asp Lys Thr Asp Lys Glu Glu Lys Ile Leu Val Phe Asp

180 185 190

Leu Gly Gly Gly Thr Phe Asp Val Ser Ile Leu Glu Leu Gly Asp Gly

195 200 205

Val Phe Asp Val Leu Ser Thr Ala Gly Asp Asn Lys Leu Gly Gly Asp

210 215 220

Asp Phe Asp Gin Lys Ile Ile Aεp His Leu Val Ala Glu Phe Lys Lys 225 230 235 240

Glu Asn Gly lie Arg Leu Val Tyr 245

(2) INFORMATION FOR SEQ ID NO: 271:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 109 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:271:

Met Lys Leu Ile Val Asp Leu Ile Tyr Glu Gly Gly Phe Lys Lys Met

1 5 10 15

Arg Gin Ser Ile Ser Asn Thr Ala Glu Tyr Gly Asp Tyr Val Ser Gly

20 25 30

Pro Arg Val Ile Thr Glu Gin Val Lys Glu Asn Met Lys Ala Val Leu

35 40 45

Ala Asp Ile Gin Asn Gly Lys Phe Ala Asn Asp Phe Val Asn Asp Tyr

50 55 60

Lys Ala Gly Arg Pro Lys Leu Thr Ala Tyr Arg Glu Gin Ala Ala Asn 65 70 75 80

Leu Glu Ile Glu Lys Val Gly Ala Glu Leu Arg Lys Ala Met Pro Phe

85 90 95

Val Gly Lys Asn Asp Asp Asp Ala Phe Lys Ile Tyr Asn 100 105

(2) INFORMATION FOR SEQ ID NO: 272:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:272:

Met Leu Leu Ser Ala Phe His Lys Tyr Glu Asn Gin Leu Asp Lys Val

1 5 10 15

Arg Phe Ile Gly Leu His Thr Gly His Leu Gly Phe Tyr Thr Asp Tyr

20 25 30

Arg Asp Phe Glu Leu Asp Lys Leu Val Thr Asn Leu Gin Leu Asp Thr

35 40 45

Gly Ala Arg Val Ser Tyr Pro Val Leu Asn Val Lys Val Phe Leu Glu

50 55 60

Asn Gly Glu Val Lys Ile Phe Arg Ala Leu Asn Glu Ala Ser Ile Arg 65 70 75 80 Arg Ser Asp Arg Thr Met Val Ala Asp Ile Val Ile Asn Gly Val Pro

85 90 95

Phe Glu Arg Phe Arg Gly Asp Gly Leu Thr Val Ser Thr Pro Thr Gly

100 105 110

Ser Thr Ala Tyr Asn 115

(2) INFORMATION FOR SEQ ID NO:273:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 207 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:273:

Met Gly Ala Gin Leu Ala Arg Glu Phe Lys His Glu Ala Asp Ile Val

1 5 10 15

Val Gly Val Pro Asn Ser Ser Leu Ser Ala Ala Met Gly Phe Ala Glu

20 25 30

Glu Ser Gly Leu Pro Asn Glu Met Gly Leu Ile Lyε Asn Gin Tyr Thr

35 40 45

Gin Arg Thr Phe Ile Gin Pro Thr Gin Glu Leu Arg Glu Gin Gly Val

50 55 60

Arg Met Lyε Leu Ser Ala Val Ser Gly Val Val Lys Gly Lys Arg Val 65 70 75 80

Val Met Val Asp Asp Ser Ile Val Arg Gly Thr Thr Ser Arg Arg Ile

85 90 95

Val Gin Leu Leu Lys Glu Ala Gly Ala Thr Glu Val His Val Ala Ile

100 105 110

Gly Ser Pro Ala Leu Ala Tyr Pro Cys Phe Tyr Gly Ile Asp Ile Gin

115 120 125

Thr Arg Gin Glu Leu Ile Ala Ala Asn His Thr Val Glu Glu Thr Arg

130 135 140

Gin Ile Ile Gly Ala Asp Ser Leu Thr Tyr Leu Ser Ile Asp Ser Leu 145 150 155 160

Ile Glu Ser Ile Gly Ile Glu Thr Asp Ala Pro Asn Gly Gly Leu Cys

165 170 175

Val Ala Tyr Phe Asp Gly Asp Tyr Pro Thr Pro Leu Tyr Asp Tyr Glu 180 185 190 Glu Asp Tyr Arg Arg Ser Leu Glu Glu Lys Thr Ser Phe Tyr Lyε 195 200 205

(2) INFORMATION FOR SEQ ID NO:274:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 215 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:274:

Met Lys Ile Leu Val Thr Gly Phe Asn Pro Phe Gly Gly Glu Lys Ile

1 5 10 15

Asn Pro Ala Leu Glu Ala Val Lys Leu Leu Pro Ser Glu Ile Asn Gly

20 25 30

Ala Glu Val Arg Trp Val Glu Ile Pro Thr Val Phe Tyr Lys Ser Ser

35 40 45

Glu Val Leu Glu Ala Glu Ile Leu Arg Tyr Gin Pro Asp Ala Val Leu

50 55 60

Cys Ile Gly Gin Ala Gly Gly Arg Thr Gly Leu Thr Pro Glu Arg Val 65 70 75 80

Ala Ile Asn Gin Asp Asp Ala Arg Ile Pro Asp Asn Glu Gly Asn Gin

85 90 95

Pro lie Asp Thr Pro Ile Arg Ile Asp Gly Ala Ser Ala Tyr Phe Ser

100 105 110

Ser Leu Pro Ile Lys Ala Met Val Gin Ala Asn Lys Lyε Glu Gly Leu

115 120 125

Thr Gly Ser Leu Phe Pro Ile Arg Ala Gly Thr Phe Val Cys Ser Hiε

130 135 140

Leu Met Tyr Gin Ala Leu Tyr Leu Val Glu Lys Lys Phe Pro Tyr Val 145 150 155 160

Lys Ala Gly Phe Met His Ile Pro Tyr Met Met Glu Gin Val Val Asn

165 170 175

Arg Pro Thr Thr Pro Thr Met Ser Leu Val Asp Ile Arg Arg Gly Ile

180 185 190

Glu Ala Ala Ile Gly Ala Met Ile Glu His Gly Asp Gin Glu Leu Thr

195 200 205

Leu Val Gly Gly Glu Ile His 210 215 (2) INFORMATION FOR SEQ ID NO:275:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 127 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 275:

Met Leu Val Pro Lys Arg Val Lys His Arg Arg Glu Phe Arg Gly Lys

1 5 10 15

Met Arg Gly Glu Ala Lys Gly Gly Lys Glu Val Ala Phe Gly Glu Tyr

20 25 30

Gly Leu Gin Ala Thr Thr Ser His Trp Ile Thr Asn Arg Gin Ile Glu

35 40 45

Ala Ala Arg Ile Ala Met Thr Arg Tyr Met Lys Arg Gly Gly Lys Val

50 55 60

Trp Ile Lys Ile Phe Pro His Lys Ser Tyr Thr Ala Lys Ala Ile Gly 65 70 75 80

Val Arg Met Gly Ser Gly Lys Gly Ala Pro Glu Gly Trp Val Ala Pro

85 90 95

Val Lys Arg Gly Lys Val Met Phe Glu Ile Ala Gly Val Ser Glu Glu

100 105 110

Ile Ala Arg Glu Ala Leu Arg Leu Ala Ser His Lys Leu Pro Val 115 120 125

(2) INFORMATION FOR SEQ ID NO: 276:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 205 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 276:

Met Gly Trp Trp Arg Glu Thr Ile Asp Ile Val Lys Glu Asn Asp Pro 1 5 10 15 Ala Ala Arg Thr Thr Leu Glu Val Leu Leu Thr Tyr Pro Gly Val Lys

20 25 30

Ala Leu Ala Ala His Arg Leu Ser His Phe Leu Trp Lys Tyr Asp Phe

35 40 45

Lys Leu Leu Ala Arg Met His Ser Gin Phe Trp Arg Phe Trp Thr Gin

50 55 60

Ile Glu Ile His Pro Gly Ala Gin Ile Asp Ser Gly Val Phe Ile Asp 65 70 75 80

His Gly Ser Gly Leu Val Ile Gly Glu Thr Ala Ile Val Glu Lys Gly

85 90 95

Val Leu Leu Tyr His Gly Val Thr Leu Gly Gly Thr Gly Lys Asp Cys

100 105 110

Gly Lys Arg His Pro Thr Val Arg Lys Gly Ala Leu Ile Ser Ala His

115 120 125

Ala Gin Val Ile Gly Pro Val Glu Ile Gly Glu Asn Ala Lys Val Gly

130 135 140

Ala Ala Ala Val Val Val Ala Asp Val Pro Ser Asp Val Thr Val Val 145 150 155 160

Gly Ile Pro Ala Lys Ile Val Arg Leu His Gly Lys Lys Asp Glu Pro

165 170 175

Val Ile His Glu Val Glu Glu Lys Arg Glu Tyr Tyr Val Asn Lys Leu

180 185 190

Glu Gin Ala Lys Asp Ala Ser His Arg Ser Ser Gly Leu 195 200 205

(2) INFORMATION FOR SEQ ID NO:277:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 195 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 277:

Met Leu Phe Tyr Leu Leu Arg Asp Gly Lys Gly Leu Arg Asn Tyr Leu

1 5 10 15

Thr Gin Phe Ile Pro Ser Lys Leu Lys Glu Pro Val Gly Gin Val Leu

20 25 30

Ser Asp Val Asn Gin Gin Leu Ser Asn Tyr Val Arg Gly Gin Val Thr 35 40 45 Val Ala Ile Ile Val Ala Val Met Phe Ile Ile Phe Phe Lys Ile Ile

50 55 60

Gly Leu Arg Tyr Ala Val Thr Leu Gly Val Thr Ala Gly Ile Leu Asn 65 70 75 80

Leu Val Pro Tyr Leu Gly Ser Phe Leu Ala Met Leu Pro Ala Leu Val

85 90 95

Leu Gly Leu Ile Ala Gly Pro Val Met Leu Leu Lys Val Val Ile Val

100 105 110

Phe Ile Val Glu Gin Thr Ile Glu Gly Arg Phe Val Ser Pro Leu Ile

115 120 125

Leu Gly Ser Gin Leu Asn Ile Hiε Pro Ile Aεn Val Leu Phe Val Leu

130 135 140

Leu Thr Ser Gly Ser Met Phe Gly Ile Trp Gly Val Leu Leu Gly Ile 145 150 155 160

Pro Val Tyr Ala Ser Ala Lys Val Val Ile Ser Ala Ile Phe Glu Trp

165 170 175

Tyr Lys Val Val Ser Gly Leu Tyr Glu Leu Glu Gly Glu Glu Val Lys

180 185 190

Ser Glu Gin 195

(2) INFORMATION FOR SEQ ID NO:278:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 56 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:278:

Met Thr Lys Gin Val Pro Lys Phe Thr Lys Asp Thr Ala Gin Leu Tyr

1 5 10 15

Thr Cys Lys Trp Leu Leu Tyr Asn Lys Val Thr Lys Met Tyr Asp His

20 25 30

Thr Val Val Asn His Ser Val Arg Glu Tyr Ile Thr Asp Ser Ile Ser

35 40 45

Thr Asn Thr Ile Glu Glu Thr Gly 50 55

(2) INFORMATION FOR SEQ ID NO:279: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 153 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:279:

Met Lys Lys Arg Ala Ile Val Ala Val Ile Val Leu Leu Leu Ile Gly

1 5 10 15

Leu Asp Gin Leu Val Lys Ser Tyr Ile Val Gin Gin Ile Pro Leu Gly

20 25 30

Glu Val Arg Ser Trp Ile Pro Asn Phe Val Ser Leu Thr Tyr Leu Gin

35 40 45

Asn Arg Gly Ala Ala Phe Ser Ile Leu Gin Asp Gin Gin Leu Leu Phe

50 55 60

Ala Val Ile Thr Leu Val Val Val Ile Gly Ala Ile Trp Tyr Leu His 65 70 75 80

Lys His Met Glu Asp Ser Phe Trp Met Val Leu Gly Leu Thr Leu Ile

85 90 95

Ile Ala Gly Gly Leu Gly Asn Phe Ile Asp Arg Val Ser Gin Gly Phe

100 105 110

Val Val Asp Met Phe His Leu Asp Phe Ile Asn Phe Ala Ile Phe Asn

115 120 125

Val Ala Asp Asn Tyr Leu Thr Val Gly Val Ile Ile Leu Leu Ile Ala

130 135 140

Met Leu Lys Glu Glu Ile Asn Gly Aεn 145 150

(2) INFORMATION FOR SEQ ID NO:280:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 106 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:280: Met Gly Ala Tyr Tyr Leu Val Met Gin Ser Leu Ser Tyr Leu Glu Tyr

1 5 10 15

Glu Gin Gly Ile Gin Ser Thr Thr Val Arg His Leu Ile Leu Val Phe

20 25 30

Tyr Leu Leu Phe Phe Met Gly Gly Ile Lys Lys Leu Asp Thr Tyr Leu

35 40 45

Lys Glu Lys Leu Gin Glu Glu Leu Asn Gin Glu Gin Thr Leu Arg Tyr

50 55 60

Arg Asp Met Glu Arg Tyr Ser Arg His Ile Glu Glu Leu Tyr Lys Glu 65 70 75 80

Ile Arg Ser Phe Arg Hiε Asp Tyr Thr Asn Leu Leu Thr Thr Tyr Val

85 90 95

Trp Ala Leu Lys Arg Arg Ile Trp Ser Arg 100 105

(2) INFORMATION FOR SEQ ID NO:281:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 113 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:281:

Met His Val Arg Met lie Pro Lys Ser Thr Pro Asp Thr Lys Phe Ala

1 5 10 15

Asp Val Ala Thr His Gin Pro Glu Tyr Ser Arg Asp Asn Val Ala Gly

20 25 30

Thr Ile Val Gly Phe Trp Thr Pro Glu Ile Phe His Gly Val Ser Val

35 40 45

Ala Gly Tyr His Leu His Phe Ile Ser Asp Asp Leu Thr Phe Gly Gly

50 55 60

His Val Met Asp Phe Val Ile Lys Glu Gly Ile Ile Glu Val Gly Ala 65 70 75 80

Val Asp Gin Leu Asp Gin Arg Phe Pro Val Gin Asp Arg Gin Tyr Leu

85 90 95

Phe Ala Lys Phe Asn Val Asp Glu Met Lys Lys Asp Ile Glu Lys Ala

100 105 110

Glu (2) INFORMATION FOR SEQ ID NO:282:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 69 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:282:

Met Ala Val Ala Lys Gly Lys Leu Thr Ile Ile Ala His Val Ala Cys

1 5 10 15

Asn Asn Thr Lys Asp Ser Met Glu Leu Ala Arg His Ala Glu Ser Leu

20 25 30

Gly Val Asp Ala Ile Ala Thr Asp Ser Thr Asn Leu Phe Pro Leu Ala

35 40 45

Arg Ile Thr Gin Leu Pro Asn Thr Gly Thr lie Ser Val Leu Gin Leu

50 55 60

Gin Thr Gin Thr Thr 65

(2) INFORMATION FOR SEQ ID NO:283:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:283:

Met Gly Glu Thr Gin Ile Ile Asp Gly Leu Asp Pro Glu Tyr Lys Lys

1 5 10 15

Arg Phe Met His His Tyr Asn Phe Pro Gin Tyr Ser Val Gly Glu Thr

20 25 30

Gly Arg Tyr Gly Ala Pro Gly Arg Arg Glu Ile Gly His Gly Ala Leu

35 40 45

Gly Glu Arg Ala Leu Ala Gin Val Leu Pro Ser Leu Glu Glu Phe Pro 50 55 60 Tyr Ala Ile Arg Leu Val Ala Glu Val Leu Glu Ser Asn Gly Ser Ser 65 70 75 80

Ser Gin Ala Ser Ile Cys Ala Gly Thr Leu Ala Leu Met Ala Gly Gly

85 90 95

Val Pro Ile Lys Ala Pro Val Ala Gly Ile Ala Met Gly Leu lie Ser

100 105 110

Asp Gly Asn Asn Tyr Thr Val Leu Thr Asp Ile Gin Gly Leu Glu Asp

115 120 125

His Phe Gly Asp Met Asp Phe Lys Val Ala Gly Thr Arg Asp Gly Ile

130 135 140

Thr Ala Leu Gin Met Asp Ile Lys Ile Gin Gly Ile Thr Ala Glu Ile 145 150 155 160

Leu Thr Glu Ala Leu Ala Gin Ala Lys Lys Ala Arg Phe Glu Ile Leu

165 170 175

Asp Val Ile Glu Ala Thr Ile Pro Glu Val Arg Pro Glu Leu Ala Pro

180 185 190

Thr Ala Pro Lys Ile Asp Thr Ile Lys Ile Asp Val Asp Lys Ile Lys

195 200 205

Ile Val Ile Gly Lys Gly Gly Glu Thr Ile Asp Lys Ile Ile Ala Glu

210 215 220

Thr Gly Val Lys Ile Asp Ile Asp Glu Glu Xaa Asn Val Phe Tyr Leu 225 230 235 240

Leu Leu Val Asp Gin Asn Ala Ile Aεn Pro Cys Pro Lys Lys Leu Leu

245 250 255

Leu Val Trp Phe Arg Glu Pro Lys Trp Met Lys Phe Thr Val Leu Asn

260 265 270

Arg Ser Tyr Arg Glu Phe Gly Ala Phe Val Thr Leu 275 280

(2) INFORMATION FOR SEQ ID NO:284:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 156 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:284:

Met Ile Asn Asn Val Val Leu Val Gly Arg Met Thr Arg Asp Ala Glu 1 5 10 15 Leu Arg Tyr Thr Pro Ser Asn Val Ala Val Ala Thr Phe Thr Leu Ala

20 25 30

Val Asn Arg Thr Phe Lys Ser Gin Asn Gly Glu Arg Glu Ala Asp Phe

35 40 45

Ile Asn Val Val Met Trp Arg Gin Gin Ala Glu Asn Leu Ala Asn Trp

50 55 60

Ala Lys Lys Gly Ser Leu Ile Gly Val Thr Gly Arg Ile Gin Thr Arg 65 70 75 80

Ser Tyr Asp Asn Gin Gin Gly Gin Arg Val Tyr Val Thr Glu Val Val

85 90 95

Ala Glu Asn Phe Gin Met Leu Glu Ser Arg Ser Val Arg Glu Gly His

100 105 110

Thr Gly Gly Ala Tyr Ser Ala Pro Thr Ala Aεn Tyr Ser Ala Pro Thr

115 120 125

Asn Ser Val Pro Asp Phe Ser Arg Asn Glu Asn Pro Phe Gly Ala Thr

130 135 140

Asn Pro Leu Asp Ile Ser Xaa Asp Asp Leu Pro Phe 145 150 155

(2) INFORMATION FOR SEQ ID NO:285:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 95 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:285:

Met Asp Leu Val Arg Ile Leu Lys Glu Pro Arg Asn Ala Leu Val Lys

1 5 10 15

Gin Tyr Gin Thr Leu Leu Ser Tyr Asp Asp Val Glu Leu Glu Phe Asp

20 25 30

Asp Glu Ala Leu Gin Glu Ile Ala Asn Lys Ala Ile Glu Arg Lys Thr

35 40 45

Gly Ala Arg Gly Leu Arg Ser Ile Ile Glu Glu Thr Met Leu Asp Val

50 55 60

Met Phe Glu Val Pro Ser Gin Glu Asn Val Lys Leu Val Arg Ile Thr 65 70 75 80

Lys Glu Thr Val Asp Gly Thr Asp Lys Pro Ile Leu Glu Thr Ala 85 90 95 (2) INFORMATION FOR SEQ ID NO:286:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:286:

Met Thr Glu Ala Gly Tyr Val Gly Glu Asp Val Glu Asn Ile Leu Leu

1 5 10 15

Lys Leu Leu Gin Val Ala Asp Phe Asn Ile Glu Arg Ala Glu Arg Gly

20 25 30

Ile Ile Tyr Val Asp Glu Ile Asp Lys Ile Ala Lys Lys Ser Glu Asn

35 40 45

Val Ser Ile Thr Arg Asp Val Ser Gly Glu Gly Val Gin Gin Ala Leu

50 55 60

Leu Lys Ile Ile Glu Gly Thr Val Ala Ser Val Pro Pro Gin Gly Gly 65 70 75 80

Arg Lys His Pro Gin Gin Val Asp Asp Ser Ser Gly Tyr Lys Lys Tyr

85 90 95

Pro Leu His Arg Gly Trp Cys Phe 100

(2) INFORMATION FOR SEQ ID NO:287:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 209 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:287:

Met Trp Pro Arg Glu Ser Arg Ser Cys Arg Leu Thr Lys Val Lyε Ile 1 5 10 15 Cys Gly Leu Ser Thr Lys Glu Ala Val Glu Thr Ala Val Ser Ala Gly

20 25 30

Ala Asp Tyr Ile Gly Phe Val Phe Ala Pro Ser Lys Arg Gin Val Thr

35 40 45

Leu Glu Glu Ala Ala Glu Leu Ala Lys Leu Ile Pro Ala Asp Val Lys

50 55 60

Lys Val Gly Val Phe Val Ser Pro Ser Arg Val Glu Leu Leu Glu Ala 65 70 75 80

Ile Asp Lyε Val Gly Leu Asp Leu Val Gin Val Hiε Gly Gin Val Ala

85 90 95

Asp Asp Leu Phe Glu Asn Leu Pro Cys Ala Ser Ile Gin Ala Val Gin

100 105 110

Val Asp Gly Asn Gly His Val Pro Asn Ser Gin Ala Asp Tyr Leu Leu

115 120 125

Phe Asp Ala Pro Val Ala Gly Ser Gly Gin Ser Phe Asp Trp Gly Gin

130 135 140

Leu Asp Thr Thr Gly Leu Ala Gin Pro Phe Phe Ile Ala Gly Gly Leu 145 150 155 160

Asn Glu Asp Asn Val Val Lys Ala Ile Gin His Phe Thr Pro Tyr Ala

165 170 175

Val Asp Val Ser Ser Gly Val Glu Thr Asp Gly Gin Lys Asp His Glu

180 185 190

Lys Ile Arg Arg Phe Ile Glu Arg Val Lys His Gly Ile Ser Gly Thr

195 200 205

Lys

(2) INFORMATION FOR SEQ ID NO:288:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:288:

Met Asn Cys Glu Ala Val Ala Leu Gly Ser Phe Cys Glu Leu Lys Ser

1 5 10 15

Arg Arg Gly Lys Lys Gin Lys Gly Glu Ile Leu Met Ala Val Ile Ser 20 25 30 Met Lys Gin Leu Leu Glu Ala Gly Val His Phe Gly His Gin Thr Arg

35 40 45

Arg Trp Asn Pro Lys Met Ala Lys Tyr Ile Phe Thr Glu Arg Asn Gly

50 55 60

Ile His Val Ile Asp Leu Gin Gin Thr Val Lys Tyr Ala Asp Gin Ala 65 70 75 80

Tyr Xaa Phe Met Arg Asp Ala Ala Ala Asn Asp Ala Val Val Leu Phe

85 90 95

Val Gly Thr Lys Lys Thr Ser Ser 100

(2) INFORMATION FOR SEQ ID NO:289:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:289:

Met Val Asp Thr Asn Thr Asp Pro Asp Asp Ile Asp Val Ile Ile Pro

1 5 10 15

Ala Asn Asp Asp Ala Ile Arg Ala Val Lys Leu Ile Thr Ala Lys Leu

20 25 30

Ala Asp Ala Ile Ile Glu Gly Arg Gin Gly Glu Asp Ala Val Ala Val 35 40 45

(2) INFORMATION FOR SEQ ID NO:290:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 141 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:290:

Met Glu Glu Leu Gly Gin Ser Tyr Gly Tyr Leu Leu Tyr Arg Thr Glu 1 5 10 15 Thr Asn Trp Asp Ala Glu Glu Glu Arg Leu Arg Ile lie Asp Gly Arg

20 25 30

Aεp Arg Ala Gin Leu Tyr Val Asp Gly Gin Trp Val Lys Thr Gin Tyr

35 40 45

Gin Thr Glu Ile Gly Glu Asp Ile Phe Tyr Gin Gly Lys Lys Lys Gly

50 55 60

Leu Ser Arg Leu Asp Ile Leu Ile Glu Asn Met Gly Arg Val Asn Tyr 65 70 75 80

Gly His Lys Phe Leu Ala Asp Thr Gin Arg Lys Gly Ile Arg Thr Gly

85 90 95

Val Cys Lys Asp Leu His Phe Leu Leu Asn Trp Lys His Tyr Pro Leu

100 105 110

Pro Leu Asp Asn Pro Glu Lys Ile Asp Phe Ser Lys Gly Trp Thr Gin

115 120 125

Gly Gin Pro Ala Phe Tyr Ala Tyr Asp Phe Thr Val Glu 130 135 140

(2) INFORMATION FOR SEQ ID NO:291:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:291:

Met Gly Lys Glu Lys Val Trp Leu Pro Arg Lys Gin Gly Leu Pro Gly

1 5 10 15

Leu Ala Tyr Tyr Val Ile Glu Val Ala His Lys Glu Glu Leu Leu Thr

20 25 30

Ile Ala Gin Arg Ala Gin Glu Val Asp Val Pro Ile Lys Trp Met Thr

35 40 45

Ser Ser Gin Leu Glu Ile Thr Asp Ser Asp Gly Ile Val Thr Cys Ile

50 55 60

Arg Leu Ala Arg 65

(2) INFORMATION FOR SEQ ID NO:292:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 65 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:292:

Met Asn Lys Lys Gin Trp Leu Gly Leu Gly Leu Val Ala Val Ala Ala

1 5 10 15

Val Gly Leu Ala Ala Cys Gly Asn Arg Ser Ser Arg Asn Ala Ala Ser

20 25 30

Ser Ser Asp Val Lys Thr Lys Ala Ala Ile Val Thr Asp Thr Gly Gly

35 40 45

Val Asp Asp Lys Ser Phe Asn Gin Ser Ala Trp Glu Val Ala Gly Leu

50 55 60

Gly 65

(2) INFORMATION FOR SEQ ID NO:293:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 157 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:293:

Met Ser Gin Trp Asp Arg Lys Leu Asp Ala Arg Leu Ala Gin Ala Val

1 5 10 15

Val Ser Ile Asn Ala Phe Lys Gly Val Glu Phe Gly Leu Gly Phe Glu

20 25 30

Ala Gly Tyr Arg Lys Gly Ser Gin Val Met Aεp Glu Ile Leu Trp Ser

35 40 45

Lys Glu Asp Gly Tyr Thr Arg Arg Thr Asn Asn Leu Gly Gly Phe Glu

50 55 60

Gly Gly Met Thr Asn Gly Gin Pro Ile Val Val Arg Gly Val Met Lys

65 70 75 80

Pro Ile Pro Thr Leu Tyr Lys Pro Leu Met Ser Val Asp Ile Glu Thr 85 90 95 His Glu Pro Tyr Lys Ala Thr Val Glu Arg Ser Asp Pro Thr Ala Leu

100 105 110

Pro Ala Ala Gly Met Val Met Glu Ala Val Val Ala Thr Val Leu Ala

115 120 125

Gin Glu Ile Leu Glu Lys Phe Ser Ser Asp Asn Leu Glu Glu Leu Lys

130 135 140

Glu Ala Val Ala Lys His Arg Asp Tyr Thr Lys Asn Tyr 145 150 155

(2) INFORMATION FOR SEQ ID NO:294:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 56 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:294:

Met Glu Asp Ser Asn Ser Phe Met Leu Ser His Gin Met Glu Thr Ile

1 5 10 15

Leu Lys Glu Ala Gly Phe Thr Lys Ala Val Ser Tyr Phe Ile Leu Glu

20 25 30

Leu Lys Asp Pro Ser Gin Thr Lys Val Val Thr Glu Glu Leu Gin Lys

35 40 45

Asn Lys Lys Tyr Thr Val Leu Ser 50 55

(2) INFORMATION FOR SEQ ID NO:295:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 65 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:295:

Met Gly Lys Lys Arg Trp Ala Arg Asn Gly Phe Glu Ser Asn Asp Ala

1 5 10 15 Ser Tyr Ala Gin Val Val Ser Leu Tyr Asp Asp Thr Ser Ile Ser Val

20 25 30

Ser Asn Asn Glu Thr Asp Lys Val Leu Ala Gly Ser Leu Tyr Thr Asp

35 40 45

Thr Asn Glu Gin Gly Leu Thr Ile Pro Ser Ser Phe Thr Lys Lys Leu

50 55 60

Glu 65

(2) INFORMATION FOR SEQ ID NO:296:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 138 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:296:

Met Ala Met Glu Ser Gly Ala Thr Ala Val Val Ala Glu Arg Gly Gin

1 5 10 15

Glu Arg Ile Thr Lys Val Arg Glu Ile Leu Gly Gly Gly Ala Asp Ala

20 25 30

Ala Leu Glu Cys Val Gly Thr Glu Ala Ala Ile Glu Gin Ala Leu Gly

35 40 45

Val Leu His Asn Gly Gly Arg Met Gly Phe Val Gly Val Pro His Tyr

50 55 60

Asn Asn Arg Ala Leu Gly Ser Thr Phe Met Gin Asn Ile Ser Val Ala 65 70 75 80

Gly Gly Ala Ala Ser Ala Thr Thr Tyr Asp Lys Gin Phe Leu Leu Lys

85 90 95

Ala Val Leu Asp Gly Asp Ile Asn Pro Gly Arg Val Phe Thr Ser Ser

100 105 110

Tyr Lys Leu Glu Asp Ile Asp Gin Ala Tyr Lys Asp Met Asp Glu Arg

115 120 125

Lyε Thr lie Lyε Ser Met Ile Val Ile Glu 130 135

(2) INFORMATION FOR SEQ ID NO:297:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 130 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:297:

Met Lys Gin Val Val Asp Tyr Phe Leu Ser Gin Gly Met Asp Arg Ile

1 5 10 15

Gly Ile Leu Thr Gly Leu Glu Glu Thr Thr Asp Gin Glu Glu Ile Ile

20 25 30

Gin Asp Lys Arg Leu Glu Asn Phe Lys Asn Tyr Ser Gin Ala Arg Gly

35 40 45

Ile Tyr His Asp Glu Leu Val Phe Gin Gly Arg Phe Thr Ala Gin Ser

50 55 60

Gly Tyr Asp Leu Met Lys Glu Ala Ile Gin Ser Leu Gly Asp Gin Leu 65 70 75 80

Pro Pro Ala Phe Phe Ala Ala Ser Asp Ser Leu Ala Ile Gly Ala Leu

85 90 95

Arg Ala Leu Gin Glu Ala Gly Ile Ser Leu Pro Asp Arg Val Ser Leu

100 105 110

Ile Phe Leu Leu Thr Thr Leu Ser Leu Thr Lys Gin Val Tyr Pro Pro

115 120 125

Leu Ser 130

(2) INFORMATION FOR SEQ ID NO:298:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:298:

Met Ala Lys Val Thr Ile Met Leu Ala Cys Ala Ala Gly Met Ser Thr

1 5 10 15

Ser Leu Leu Val Thr Lys Met Gin Lys Ala Ala Glu Asp Lys Gly Leu 20 25 30 Asp Ala Glu Ile Phe Ala Val Pro Ala Pro Glu Ala Glu Glu Ile Val

35 40 45

Ala Thr Lys Glu Val Asn Val Leu Leu Leu Gly Pro Gin Val Arg Tyr

50 55 60

Leu Leu Gly Asp Phe Gin Glu Lys Leu Lys Asp Arg Gin Ile Pro Val 65 70 75 80

Ala Val Ile Pro Met Thr Asp Tyr Gly Met Met Asn Gly Ser Lys Val

85 90 95

Leu Asp Leu Ala Glu Ser Leu Leu Asp 100 105

(2) INFORMATION FOR SEQ ID NO:299:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 127 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:299:

Met His Gly Ala Gly Val Asn Glu Pro Val Ala Glu Leu Ser Val Ala

1 5 10 15

Glu Gin Leu Leu Glu Ala Gly Ala Asp Val Ile Leu Val Pro Ala Val

20 25 30

Gly Thr Val Pro Ala Phe His Asp Gin Glu Leu Arg Glu Val Val Asp

35 40 45

Leu Val His Ser Lys Gly Gly Leu Val Leu Ser Ala Ile Gly Thr Ser

50 55 60

Gin Glu Thr Ser Asp Thr Asp Thr Ile Lys Glu Ile Ala Leu Arg Asn 65 70 75 80

Lys Ile Cys Gly Val Aεp Ile Gin His Ile Gly Asp Ala Gly Tyr Gly

85 90 95

Gly Leu Ala Thr Val Asp Asn Ile Tyr Ala Leu Ser Lys Ala Ile Arg

100 105 110

Gly Val Arg His Thr Val Ser Arg Leu Ala Arg Ser Val Asn Arg 115 120 125

(2) INFORMATION FOR SEQ ID NO:300:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 236 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:300:

Met Ser Ala Ile Asn Leu Ala Ser Val Pro Lys Glu Ser Leu Thr Gin

1 5 10 15

Val Leu Pro Arg Asp Leu His Ala Glu Tyr Phe Ala Val Leu Ala Ser

20 25 30

Ile Ala Thr Ser Ile Glu Arg Met Ala Thr Glu Ile Arg Gly Leu Gin

35 40 45

Lys Ser Glu Gin Arg Glu Val Glu Glu Phe Phe Ala Lys Gly Gin Lys

50 55 60

Gly Ser Ser Ala Met Pro His Lys Arg Asn Pro Ile Gly Ser Glu Asn 65 70 75 80

Met Thr Gly Leu Ala Arg Val Ile Arg Gly His Met Ile Thr Ala Tyr

85 90 95

Glu Asn Val Ala Leu Trp His Glu Arg Asp Ile Ser His Ser Ser Ala

100 105 110

Glu Arg Ile Ile Thr Pro Asp Thr Thr Ile Leu Ile Asp Tyr Met Leu

115 120 125

Asn Arg Phe Gly Asn Ile Val Lys Asn Leu Thr Val Phe Pro Glu Asn

130 135 140

Met Ile Arg Asn Met Asn Ser Thr Phe Gly Leu Ile Phe Ser Gin Arg 145 150 155 160

Ala Met Leu Thr Leu Ile Glu Lys Gly Met Thr Arg Glu Gin Ala Tyr

165 170 175

Asp Leu Val Gin Pro Lys Thr Ala Tyr Ser Trp Asp Asn Gin Val Asp

180 185 190

Phe Lys Pro Leu Leu Glu Ala Asp Ser Glu Val Thr Ser Arg Leu Thr

195 200 205

Gin Glu Glu Ile Asp Glu lie Phe Asn Pro Val Tyr Tyr Thr Lys Arg

210 215 220

Val Asp Aεp Ile Phe Glu Arg Leu Gly Leu Gly Asp 225 230 235

(2) INFORMATION FOR SEQ ID NO:301:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 amino acids

(B) TYPE: amino acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:301:

Met Leu Asn Leu Thr His Val Thr Leu Lys Thr Arg Gin Val Ile Leu

1 5 10 15

Gin Asp Ala Asp Phe Thr Phe Lys Lys Gly Arg Ile Tyr Gly Leu Leu

20 25 30

Ala Ile Aεn Gly Ser Gly Lys Thr Thr Leu Phe Arg Ala Met Ser Lys

35 40 45

Leu Leu Pro Leu Ser Ser Gly His Ile Ala Val Pro Pro Ser Leu Phe

50 55 60

Tyr Tyr Glu Ser Val Glu Trp Leu Asp Gly Asn Leu Ser Gly Met Asp 65 70 75 80

Tyr Leu Arg Leu Ile Lys Lys His Leu Glu Val Arg Pro Lys Leu Glu

85 90 95

Arg

(2) INFORMATION FOR SEQ ID NO:302:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 56 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:302:

Met Tyr Thr Leu Gly Gin Pro Asn Glu Leu Ala Ala Glu Phe Leu Asn

1 5 10 15

Phe Val Leu Ser Asp Glu Thr Gin Glu Gly Ile Val Lys Gly Leu Lys

20 25 30

Tyr Ile Pro Ile Lys Glu Met Lys Val Glu Lys Asp Ala Ala Gly Thr

35 40 45

Val Thr Val Leu Glu Gly Arg Gin 50 55

(2) INFORMATION FOR SEQ ID NO:303: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 187 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:303:

Met Asn Gin Glu Glu Leu Ala Lys Lys Met Leu Leu Pro Ser Lys Asn

1 5 10 15

Ser Arg Leu Glu Lys Leu Gly Lys Gly Leu Thr Phe Ala Cys Leu Ser

20 25 30

Leu Ile Val Ile Leu Val Ala Met Ile Leu Val Phe Val Ala Gin Lys

35 40 45

Gly Leu Ser Thr Phe Phe Val Asn Gly Val Asn Ile Phe Asp Phe Leu

50 55 60

Leu Gly Gly Thr Trp Asn Pro Ser Ser Lys Glu Phe Gly Ala Leu Pro 65 70 75 80

Met Ile Leu Gly Ser Phe Ile Val Thr Ile Leu Ser Ala Leu Ile Ala

85 90 95

Thr Pro Phe Ala Ile Gly Ala Ala Val Phe Met Thr Glu Val Ser Pro

100 105 110

Lys Gly Ala Lys Ile Leu Gin Pro Ala lie Glu Leu Leu Val Gly Ile

115 120 125

Pro Ser Val Val Tyr Gly Phe Ile Gly Leu Gin Val Val Val Pro Phe

130 135 140

Val Arg Ser Val Phe Gly Gly Thr Gly Phe Gly Ile Leu Ser Gly Ile 145 150 155 160

Ser Val Leu Phe Val Met Ile Leu Pro Thr Val Thr Phe Met Thr Thr

165 170 175

Asp Ser Leu Arg Ala Val Pro Xaa Leu Leu Ser 180 185

(2) INFORMATION FOR SEQ ID NO:304:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 242 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

( i) SEQUENCE DESCRIPTION: SEQ ID NO:304:

Met Thr Glu Ile Arg Leu Glu His Val Ser Tyr Ala Tyr Gly Gin Glu

1 5 10 15

Arg Ile Leu Glu Asp Ile Asn Leu Gin Val Thr Ser Gly Glu Val Val

20 25 30

Ser Ile Leu Gly Pro Ser Gly Val Gly Lys Thr Thr Leu Phe Asn Leu

35 40 45

Ile Ala Gly Ile Leu Glu Val Gin Ser Gly Arg Ile Val Leu Aεp Gly

50 55 60

Glu Glu Aεn Pro Lys Gly His Val Ser Tyr Met Leu Gin Lys Asp Leu 65 70 75 80

Leu Leu Glu His Lys Thr Val Leu Gly Asn Ile Ile Leu Pro Leu Leu

85 90 95

Ile Gin Lys Val Asp Lys Ala Glu Ala Ile Ser Arg Ala Asp Lys Ile

100 105 110

Leu Ala Thr Phe Gin Leu Thr Ala Val Arg Asp Lys Tyr Pro His Glu

115 120 125

Leu Ser Gly Gly Met Arg Gin Arg Val Ala Leu Leu Arg Thr Tyr Leu

130 135 140

Phe Gly His Lys Leu Phe Leu Leu Asp Glu Ala Phe Ser Ala Leu Asp 145 150 155 160

Glu Met Thr Lys Met Glu Leu His Ala Trp Tyr Leu Glu Ile His Lys

165 170 175

Gin Leu Gin Leu Thr Thr Leu Ile Xaa Thr His Ser Ile Glu Glu Ala

180 185 190

Leu Xaa Leu Ser Asp Arg Ile Tyr Ile Leu Xaa Asn Xaa Pro Gly Gin

195 200 205

Ile Val Ser Glu Ile Lys Leu Asp Trp Ser Glu Asp Glu Asp Xaa Glu

210 215 220

Val Xaa Lys Ile Ala Xaa Lys Arg Gin Ile Leu Ala Glu Leu Gly Leu 225 230 235 240

Asp Lys

(2) INFORMATION FOR SEQ ID NO: 305:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 79 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

( i) SEQUENCE DESCRIPTION: SEQ ID NO:305:

Met Glu His Pro Xaa Glu Ala Ala Asp Ile Leu Ile Lys Asn Ala Pro

1 5 10 15

Glu Leu Lys Glu Lys Arg Asp Phe Val Ile Glu Ser Gin Lys Tyr Leu

20 25 30

Ser Lys Glu Tyr Ala Ser Asp Lys Glu Lys Trp Gly Gin Phe Asp Ala

35 40 45

Ala Arg Trp Asn Ala Phe Tyr Lys Trp Asp Lys Glu Asn Gly Ile Leu

50 55 60

Lys Glu Asp Leu Thr Asp Lys Gly Phe Thr Asn Glu Phe Val Lys 65 70 75

(2) INFORMATION FOR SEQ ID NO:306:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 155 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:306:

Met Val Tyr Thr Ser Leu Ser Ser Lys Asp Gly Asn Tyr Pro Tyr Gin

1 5 10 15

Leu Aεn Ile Ala His Leu Tyr Gly Asn Leu Met Asn Thr Tyr Gly Asp

20 25 30

Asn Gly Asn Ile Leu Met Leu Lys Tyr Val Ala Glu Lys Leu Gly Thr

35 40 45

His Val Thr Val Asp Ile Val Ser Leu His Asp Asp Phe Asp Glu Asn

50 55 60

His Tyr Asp Ile Ala Phe Phe Gly Gly Gly Gin Asp Phe Glu Gin Ser 65 70 75 80

Ile lie Ala Asp Asp Leu Pro Ala Lys Lys Glu Ser Ile Asp Asn Tyr

85 90 95

Ile Gin Asn Asp Gly Val Val Leu Ala Ile Cys Gly Gly Phe Gin Leu

100 105 110

Leu Gly Gin Tyr Tyr Val Glu Ala Ser Gly Lys Arg Ile Glu Gly Leu 115 120 125 Gly Val Met Gly His Tyr Thr Leu Asn Gin Thr Asn Asn Arg Phe Ile

130 135 140

Gly Asp Ile Lys Ile His Asn Glu Arg Phe Arg 145 150 155

(2) INFORMATION FOR SEQ ID NO:307:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 307:

Met His Gin His Ser Pro His Thr Ala Ser Tyr Thr Ser Ser Arg Asp

1 5 10 15

Ala Met Ser Lys Tyr Pro Glu Arg Cys Thr Thr Val Gly Leu Arg Leu

20 25 30

Asn Glu Glu Ser Asp Phe Glu Leu Tyr Ala Pro Tyr Gly Leu Glu Asp

35 40 45

Ile Leu Asn Phe Lys Phe Val Gin Leu Leu Ile Ser 50 55 60

(2) INFORMATION FOR SEQ ID NO: 308:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:308:

Met Phe Glu Ile Phe Asn Met Gly Val Gly Leu Met Leu Ala Val Ser

1 5 10 15

Pro Glu Asn Val Glu Arg Val Lys Glu Leu Leu Asp Glu Ala Val Tyr

20 25 30

Glu Ile Gly Arg Ile Val Lys Lys Glu Asn Glu Ser Val Ile Ile Lys 35 40 45 (2) INFORMATION FOR SEQ ID NO:309:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 309:

Met Met Val Lys Lys His Tyr Phe Lys Asp Asn Glu Glu Asp Ser Lys

1 5 10 15

Met Arg Arg Ile Leu Leu Leu Val Ala Val Leu Leu Met Ile Pro Ser

20 25 30

Phe Ile Ser Ala Thr Thr Leu Val Arg Glu Thr Leu Lys Lys Glu Ser

35 40 45

Leu Lys Lys Phe Ile Ser Glu Gin Phe Gin Gly His Asn lie Leu Lys

50 55 60

Lys Thr Tyr Ser Lys Lys Thr His Thr Leu Lys Leu Thr Ile Ser Gly 65 70 75 80

Asn Tyr Leu Thr Glu Glu Glu Leu Asp Met Ile Ser Ser Lys Arg Gly

85 90 95

Asp Tyr Gly Leu Ser Asp Val Ser Val Gin Val Ser Gin Leu Ser Asp

100 105 110

Ser Glu Gin Leu Ser Lys Glu Glu Leu Val Glu Tyr Phe Phe Gin Tyr

115 120 125

Ile Lys Asp Lys Glu Ala Lys Glu Lys Glu Lys Ala Asn Lys Phe Tyr

130 135 140

Thr Glu Ser Glu Glu Gin 145 150

(2) INFORMATION FOR SEQ ID NO:310:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310:

Met Ser Ile Glu Pro Arg Arg Arg Trp Arg Asn Ser Thr Val Cys Leu

1 5 10 15

Glu Ala Glu Leu Tyr Gin Glu Ser Leu Val Leu Ile Gly Gly Asp Pro

20 25 30

Gly Ile Gly Lys Ser Thr Leu Leu Leu Gin Val Ser Thr Gin Leu Ser

35 40 45

Gin Val Gly Thr Val Leu Tyr Val Ser Gly Glu Glu Ser Ala Gin Gin

50 55 60

Ile Lys Leu Arg Ala Glu Arg Leu Gly Asp Phe Asp Ser Glu Phe Tyr 65 70 75 80

Leu Tyr Ala Glu Thr Asn Met Gin Ser Val Arg Ala Glu Val Val Ala

85 90 95

Tyr Pro Ala Arg Leu Ser His Tyr 100

(2) INFORMATION FOR SEQ ID NO:311:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 159 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:311:

Met Ala Thr Lys Gin Lys Glu Val Thr Thr Phe Asp Val Gin Val Ala

1 5 10 15

Glu Phe Ile Arg Asn His Lys Gin Lys Gly Thr Ala Thr Asp Asp Glu

20 25 30

Ile Asn Ala Ser Leu Val Ile Pro Phe Thr Leu Asp Ala Asp Gly Ile

35 40 45

Glu Asp Leu Leu Gin Arg Ile Gin Asp Ala Gly Ile Ser Ile Thr Asp

50 55 60

Asn Glu Gly Asn Pro Ser Ala Arg Val Leu Ser Asn Glu Glu Glu Pro 65 70 75 80

Glu Leu Ser Asp Glu Asp Leu Ile Gly Ser Thr Ser Ala Lys Val Asn

85 90 95

Asp Pro Val Arg Met Tyr Leu Lys Glu Ile Gly Val Val Pro Leu Leu 100 105 110 Thr Asn Glu Glu Glu Lys Glu Leu Ala Leu Ala Val Glu Ala Gly Asp

115 120 125

Ile Glu Ala Lys Gin Arg Leu Ala Glu Ala Asn Leu Arg Leu Val Val

130 135 140

Ser Ile Ala Lys Arg Tyr Val Gly Arg Gly Xaa Gin Ser Leu Thr 145 150 155

(2) INFORMATION FOR SEQ ID NO:312:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

( i) SEQUENCE DESCRIPTION: SEQ ID NO:312:

Met Met Leu Lys Pro Ser Ile Asp Thr Leu Leu Asp Lys Val Pro Ser

1 5 10 15

Lys Tyr Ser Leu Val Ile Leu Glu Ala Lys Arg Ala His Glu Leu Glu

20 25 30

Ala Gly Ala Pro Ala Thr Gin Gly Phe Lys Ser Glu Lys Ser Thr Leu

35 40 45

Arg Ala Leu Glu Glu Ile Glu Ser Gly Aεn Val Thr Ile His Pro Asp

50 55 60

Pro Glu Gly Lys Arg Glu Ala Val Arg Arg Arg lie Glu Glu Glu Lys 65 70 75 80

Arg Arg Lys Glu Glu Glu Glu Lys Lys Ile Lys Glu Gin Ile Ala Lys

85 90 95

Glu Lys Glu Asp Gly Glu Lys Ile 100

(2) INFORMATION FOR SEQ ID NO:313:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 144 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:313:

Met Ile Arg Gin Gly Gin Met Leu Glu Tyr Ala Glu Tyr Val Gly Asn

1 5 10 15

Tyr Tyr Gly Thr Pro Leu Thr Tyr Val Asn Glu Thr Leu Asp Lys Gly

20 25 30

Ile Asp Val Phe Leu Glu Ile Glu Val Gin Gly Ala Leu Gin Val Lys

35 40 45

Lyε Lyε Val Pro Asp Ala Val Phe Ile Phe Leu Thr Pro Pro Asp Leu

50 55 60

Asp Glu Leu Gin Glu Arg Leu Val Gly Arg Gly Thr Asp Ser Ala Glu 65 70 75 80

Val Ile Ala Gin Arg Ile Glu Lyε Ala Lys Glu Glu Ile Ala Leu Met

85 90 95

Arg Glu Tyr Asp Tyr Ala Ile Val Asn Asp Gin Val Pro Leu Ala Ala

100 105 110

Glu Arg Val Lys Cyε Val Ile Glu Ala Glu His Phe Cys Val Asp Arg

115 120 125

Val Ile Gly His Tyr Gin Glu Met Leu Pro Lys Ser Pro Thr Thr Arg 130 135 140

(2) INFORMATION FOR SEQ ID NO:314:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:314:

Met Ser Arg Leu Leu Val Ile Gly Cyε Gly Gly Val Ala Gin Val Ala

1 5 10 15

Ile Ser Lys Ile Cys Gin Asp Ser Glu Thr Phe Thr Glu Ile Met Ile

20 25 30

Ala Ser Arg Thr Lys Ser Lys Cys Asp Asp Leu Lys Ala Lys Leu Glu

35 40 45

Gly Lys Thr Ser Thr Lys Ile Glu Thr Ala Ala Leu Asp Ala Asp Lys

50 55 60

Val Glu Glu Val Ile Ala Leu Ile Glu Ser Leu Gin Thr Ser Lys Leu 65 70 75 80

Phe ( 2 ) INFORMATION FOR SEQ ID NO : 315 :

( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 36 amino acids

(B ) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:315:

Met His Glu Ser Phe His Val Asp Asp Pro Thr Leu Tyr Ser Arg Glu

1 5 10 15

Trp Phe Ser Trp Ala Asn Met Met Phe Cys Glu Leu Val Leu Asp Tyr

20 25 30

Leu Asp Ile Arg 35

(2) INFORMATION FOR SEQ ID NO:316:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 65 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:316:

Met Arg Phe Tyr Phe Met Glu Asn Val Val Val His Ile Ile Ser His

1 5 10 15

Ser His Trp Asp Arg Glu Trp Tyr Leu Pro Phe Glu Ser His Arg Met

20 25 30

Gin Leu Val Glu Leu Phe Asp Asn Leu Phe Asp Leu Phe Glu Asn Asp

35 40 45

Pro Glu Phe Lys Ser Phe His Leu Asp Gly Gin Thr Ile Val Leu Asp

50 55 60

Asp 65 ( 2 ) INFORMATION FOR SEQ ID NO : 317 :

( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 253 amino acids

( B ) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:317:

Met Leu Leu Tyr Ile Leu Ser Hiε Ile Ala Thr Gly Ile Val Ser Gly

1 5 10 15

Thr Cys Leu Leu Lys Ala Ile Val Cys Asn Trp Trp Asn Cys Leu Thr

20 25 30

Ile Ser Leu Ile Ser Leu Lys Met Thr Leu Ser Ser Arg Val Ser Thr

35 40 45

Trp Met Asp Lys Leu Leu Ser Leu Thr Thr Asn Leu Gin Ile Arg Pro

50 55 60

Glu Asn Arg Asp Lys Val Gin Arg Tyr Ile Asp Glu Gly Lys Leu Lys 65 70 75 80

Ile Gly Pro Phe Tyr Ile Leu Gin Asp Asp Tyr Leu Ile Ser Ser Glu

85 90 95

Ala Asn Val Arg Asn Thr Leu Ile Gly Gin Gin Glu Ala Ala Lys Trp

100 105 110

Gly Lys Ser Thr Gin Ile Gly Tyr Phe Pro Aεp Thr Phe Gly Aεn Met

115 120 125

Gly Gin Ala Pro Gin Ile Leu Gin Lyε Ser Gly Ile Hiε Val Ala Ala

130 135 140

Phe Gly Arg Gly Val Lys Pro Ile Gly Phe Aεp Asn Gin Val Leu Glu 145 150 155 160

Asp Glu Gin Phe Thr Ser Gin Phe Ser Glu Met Tyr Trp Gin Gly Val

165 170 175

Asp Gly Ser Arg Val Leu Gly Ile Leu Phe Ala Asn Trp Tyr Ser Asn

180 185 190

Gly Asn Glu Ile Pro Val Asp Lys Asp Glu Ala Leu Thr Phe Trp Lyε

195 200 205

Gin Lyε Leu Ser Asp Val Arg Cys Leu Arg Phe Asp Gin Pro Met Val

210 215 220

Asp Asp Glu Thr Ala Val Asn Thr Ser Leu Ser Gin Lys Lys Ser Glu 225 230 235 240

Arg Ser Hiε Ser Val Trp Gin Met Aεn Ser Ser Arg Met 245 250 (2) INFORMATION FOR SEQ ID NO:318:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 99 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

( i) SEQUENCE DESCRIPTION: SEQ ID NO:318:

Met Thr Ile Val Gly Cys Arg Ile Asp Gly Arg Leu Ile His Gly Gin

1 5 10 15

Val Ala Asn Leu Trp Ala Gly Lys Leu Asn Val Ser Arg Ile Met Val

20 25 30

Val Asp Asp Glu Val Val Asn Asn Asp Ile Glu Lys Ser Gly Leu Lys

35 40 45

Leu Ala Thr Pro Pro Gly Val Lys Leu Ser Ile Leu Pro Val Glu Lys

50 55 60

Ala Ala Ala Asn Ile Leu Ala Gly Lys Tyr Asp Ser Gin Arg Leu Phe 65 70 75 80

Ile Val Ala Arg Lys Pro Asp Arg Phe Pro Trp Phe Gly Arg Ser Arg

85 90 95

Cys Thr Thr

(2) INFORMATION FOR SEQ ID NO:319:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 157 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:319:

Met Ile Gin His Pro Arg Ile Gly Ile Arg Pro Thr Ile Asp Gly Arg

1 5 10 15

Arg Gin Gly Val Arg Glu Ser Leu Glu Val Gin Thr Met Asn Met Ala 20 25 30 Lys Ser Val Ala Aεp Leu Ile Ser Ser Thr Leu Lys Tyr Pro Asp Gly

35 40 45

Glu Pro Val Glu Cyε Val Ile Ser Pro Ser Thr Ile Gly Arg Val Pro

50 55 60

Glu Ala Ala Ala Ser His Glu Leu Phe Lys Lys Ser Asn Val Cys Ala 65 70 75 80

Thr Ile Thr Val Thr Pro Cys Trp Cys Tyr Gly Ser Glu Thr Met Asp

85 90 95

Met Ser Pro Asp Ile Pro His Ala Ile Trp Gly Phe Asn Gly Thr Glu

100 105 110

Arg Pro Gly Ala Val Tyr Leu Ala Ala Val Leu Ala Ser His Ala Gin

115 120 125

Lys Gly Ile Pro Ala Phe Gly Ile Tyr Gly Arg Asp Val Gin Glu Ala

130 135 140

Asn Asp Thr Asp Ile Pro Glu Asp Val Lys Glu Asn Phe 145 150 155

(2) INFORMATION FOR SEQ ID NO:320:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 51 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 320:

Met Leu Leu Ser Thr Lys Gly Ile Glu Glu Gin Glu Ile Ala Arg Pro

1 5 10 15

Thr Leu Glu Arg Leu Phe Ser Met Arg Glu Asn Tyr Lyε Val Thr Gly

20 25 30

Arg His Pro Gly Tyr Arg Lys Tyr Asn Gly Asp Gly Ser Met Lys Glu

35 40 45

Thr Glu Lys 50

(2) INFORMATION FOR SEQ ID NO: 321:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY : linear

(ii ) MOLECULE TYPE : protein

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 321 :

Met Leu Thr Leu Thr Pro Asp Val Ile Tyr Gin Glu Pro Asp Ile Leu

1 5 10 15

Tyr Gin His Glu Asp Phe Ser Leu Val Lys Ile Arg Gin Ile Arg Phe

20 25 30

Cyε

(2) INFORMATION FOR SEQ ID NO:322:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:322:

Met Ser Ser Val Val Gly Leu Met Gly Asn Ile Gly Gin Ala Asn Tyr

1 5 10 15

Ala Ala Ser Lys Ala Gly Leu Ile Gly Phe Thr Lys Ser Val Ala Arg

20 25 30

Glu Val Ala Ser Arg Asn lie Arg Val Asn Val Ile Ala Pro Gly Asn

35 40 45

Asp

(2) INFORMATION FOR SEQ ID NO:323:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 127 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:323:

Met Lys Leu Glu His Lys Asn Ile Phe Ile Thr Gly Ser Ser Arg Gly

1 5 10 15

Ile Gly Leu Ala Ile Ala His Lys Phe Ala Gin Ala Gly Ala Asn Ile

20 25 30

Val Leu Asn Ser Arg Gly Ala Ile Ser Glu Glu Leu Leu Ala Glu Phe

35 40 45

Ser Asn Tyr Gly Ile Lys Val Val Pro Ile Ser Gly Asp Val Ser Asp

50 55 60

Phe Ala Asp Ala Lys Arg Met Ile Asp Gin Ala Ile Ala Glu Leu Gly 65 70 75 80

Ser Val Asp Val Leu Val Asn Asn Ala Gly Ile Thr Gin Asp Thr Leu

85 90 95

Met Leu Lys Met Thr Glu Ala Asp Phe Glu Lys Val Leu Lys Val Asn

100 105 110

Leu Thr Gly Ala Phe Asn Met Thr Gin Ser Val Phe Gly Asn Arg 115 120 125

(2) INFORMATION FOR SEQ ID NO:324:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 66 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:324:

Met Glu Ser Met Pro Arg Ile Gly Leu Leu Val Thr Val Glu Asn Arg

1 5 10 15

Asp Thr Glu Thr Ile Phe Asn Ala Ala Gly Leu Asp Phe Asp Val Leu

20 ^' 25 30

Lys Ala Ser Ala Ile Ala Tyr Ile Asn Ala Asn Thr Phe Val Gin Lys

35 40 45

Glu Asn Ala Gly Glu Met Gly Arg Ser Val Ser Tyr His Asp Met Arg

50 55 60

Ser Val 65

(2) INFORMATION FOR SEQ ID NO: 325: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

( i) SEQUENCE DESCRIPTION: SEQ ID NO:325:

Met Arg Gin Gly Gin Gly Ser Val Glu Ala Ile Phe Asn Ala Ile Asp

1 5 10 15

Lys Phe Phe Aεn Gin Ser Val Arg Leu Val Ser Tyr Thr Ile Asn Ala

20 25 30

Val Thr Asp Gly Ile Asp Ala Gin Asp Arg Val Val Gly His Cys 35 40 45

(2) INFORMATION FOR SEQ ID NO:326:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:326:

Met Val Glu Asn Pro Glu Gly Phe His Phe Asp Asp Leu Gin Leu Gin

1 5 10 15

Thr His Ala Aεp Aεn Asp Ile Glu Ala Leu Val Ser Leu Ala Asn Met

20 25 30

Asp Gly Glu Lys Val Glu Phe Asn Ala Thr Gly Thr Gly Phe Arg 35 40 45

(2) INFORMATION FOR SEQ ID NO:327:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 210 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:327:

Met Asn Phe Gin Leu Ala Lys Tyr Ser Leu Leu Lys Lys Phe Ser Glu

1 5 10 15

Asn Ile Gly Phe Thr Thr Pro Glu Glu Cys Gly Ala Ile Phe Gin Tyr

20 25 30

Leu Ile Glu Asn Val Gin Thr Asp Arg Gin lie lie Tyr Ser Pro Pro

35 40 45

Cys His Asp Glu Leu Arg Met Ala Val Ala Asn Ser Leu Ala Ala Val

50 55 60

Lys Asn Gly Ala Gly Leu Phe Glu Glu Thr Ile His Gly Ile Arg Glu 65 70 75 80

Arg Ala Glu Asn Ala Ala Leu Glu Glu Ile Ala Val Ala Leu Asn Ile

85 90 95

Arg Gin Asp Tyr Tyr Gin Val Glu Thr Ser Ile Val Leu Asn Glu Thr

100 105 110

Ile Asn Thr Ser Glu Met Val Ser Arg Phe Ser Gly Ile Pro Val Pro

115 120 125

Lys Asn Lys Ala Val Val Gly Gly Asn Thr Phe Ser His Glu Ser Gly

130 135 140

Ile His Gin Asp Gly Val Leu Lys Asn Pro Leu Thr Tyr Glu Ile Ile 145 150 155 160

Thr Pro Glu Leu Val Gly Val Lys Ile Pro Leu Gly Lys Leu Ser Gly

165 170 175

Arg His Ala Phe Val Glu Lys Leu Arg Glu Leu Ala Leu Asp Phe Thr

180 185 190

Glu Glu Asp Ile Lys Pro Phe Phe Ala Lys Phe Lys Ala Leu Ala Asp

195 200 205

Lys Lys 210

(2) INFORMATION FOR SEQ ID NO:328:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 99 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 328: Met Ser Gin Gin Val Lys Asn Ala His Asn Leu Tyr Ile His Ala Ile

1 5 10 15

Gin Asp Gly Arg Val Ala Glu Ala Gin Ala Gin Ser Val Gly Asp Thr

20 25 30

Tyr Ile Gin His Ser Thr Gly Val Pro Asp Gly Lys Glu Gly Phe Ala

35 40 45

Ala Phe Phe Ala Asp Phe Phe Glu Arg His Pro Glu Arg Gin Ile Lys

50 55 60

Ile Val Arg Thr Ile Glu Asp Gly Asn Leu Val Phe Val His Val Pro 65 70 75 80

Ser Ile Ser Glu Trp Trp Arg Ser Ser Met Gly Asp Asp Gly Tyr Phe

85 90 95

Pro Cys Gly

(2) INFORMATION FOR SEQ ID NO:329:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 122 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 329:

Met Glu Met Gin Thr Ser Ala Gin Leu Leu Thr Asn Lys Ile Phe Leu

1 5 10 15

Lys Asn Pro Leu Lys Ala Leu Val Glu Glu Lys Tyr Gly Ile Glu Tyr

20 25 30

Glu Glu Phe Thr Asn Pro Trp His Ala Ala Ile Ser Ser Phe Val Ala

35 40 45

Phe Phe Leu Arg Ser Leu Pro Pro Met Leu Ser Val Thr Ile Phe Pro

50 55 60

Ser Glu Tyr Arg Ile Pro Ala Thr Val Leu Ile Val Gly Val Ala Leu 65 70 75 80

Leu Leu Thr Gly Tyr Thr Ser Ala Arg Leu Gly Lys Asp Pro Thr Arg

85 90 95

Thr Ala Met Ile Arg Asn Leu Ala Ile Gly Leu Leu Thr Met Gly Val

100 105 110

Thr Phe Leu Leu Glu Gin Leu Phe Ser Ile 115 120 (2) INFORMATION FOR SEQ ID NO:330:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 194 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 330:

Met Ala Phe Phe Leu Cys Pro His Phe Arg Ser Asn His Trp Lys Ile

1 5 10 15

Leu Thr Val Ser Asp Thr Met Glu Glu Lys Arg Leu Glu Tyr Pro Met

20 25 30

Val Thr Phe Leu Gly Asn Pro Val Ser Phe Thr Gly Lys Gin Leu Gin

35 40 45

Val Gly Asp Lys Ala Leu Asp Phe Ser Leu Thr Thr Thr Asp Leu Ser

50 55 60

Lys Lys Ser Leu Ala Asp Phe Asp Gly Lys Lys Lys Val Leu Ser Val 65 70 75 80

Val Pro Ser Ile Asp Thr Gly Ile Cys Ser Thr Gin Thr Arg Arg Phe

85 90 95

Asn Glu Glu Leu Ala Gly Leu Asp Aεn Thr Val Val Leu Thr Val Ser

100 105 110

Met Aεp Leu Pro Phe Ala Gin Lys Arg Trp Cyε Gly Ala Glu Gly Leu

115 120 125

Asp Asn Ala Ile Met Leu Ser Asp Tyr Phe Asp His Ser Phe Gly Arg

130 135 140

Asp Tyr Ala Leu Leu Ile Asn Glu Trp His Leu Leu Ala Arg Ala Val 145 150 155 160

Phe Val Leu Asp Thr Asp Asn Thr Ile Arg Tyr Val Glu Tyr Val Asp

165 170 175

Asn Ile Asn Ser Glu Pro Asn Phe Glu Ala Ala Ile Ala Ala Ala Lys

180 185 190

Ala Leu

(2) INFORMATION FOR SEQ ID NO:331:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 48 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:331:

Met Gly Tyr Arg Pro Ser Thr Ala Asn Ala Ile Ile His Gin Val Arg

1 5 10 15

Glu Leu Leu Val Ser Arg Gly Tyr Thr Phe Tyr Asn Arg Lys Arg Leu

20 25 30

Met Val Val Pro Lys Ser Val Val Lys Glu Leu Leu Gly Met Glu Leu 35 40 45

(2) INFORMATION FOR SEQ ID NO:332:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 219 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:332:

Met Gin Ala Val Glu His Phe Ile Lys Gin Phe Val Pro Glu His Tyr

1 5 10 15

Asp Leu Phe Leu Asp Leu Ser Arg Glu Thr Lys Thr Phe Ser Gly Lys

20 25 30

Val Thr Ile Thr Gly Gin Ala Gin Ser Asp Arg Ile Ser Leu His Gin

35 40 45

Lys Asp Leu Glu Ile Thr Ser Val Glu Val Ala Gly Gin Ala Arg Pro

50 55 60

Phe Thr Val Asp His Asp Asn Glu Ala Leu His Ile Glu Leu Ala Glu 65 70 75 80

Ala Gly Gin Val Glu Leu Val Leu Ala Phe Ser Gly Lys Ile Thr Asp

85 90 95

Asn Met Thr Gly Ile Tyr Pro Ser Tyr Tyr Thr Val Asp Gly Val Lys

100 105 110

Lys Glu Val Leu Ser Thr Gin Phe Glu Ser His Phe Ala Arg Glu Ala 115 120 125 Phe Pro Cys Val Asp Glu Pro Glu Ala Lys Ala Thr Phe Aεp Leu Ser

130 135 140

Leu Arg Phe Asp Gin Ala Glu Gly Glu Leu Ala Leu Ser Asn Met Pro 145 150 155 160

Glu Ile Asp Val Glu Asn Arg Lys Glu Thr Gly Ile Trp Lyε Phe Glu

165 170 175

Thr Thr Pro Arg Met Ser Ser Tyr Leu Leu Ala Phe Val Ala Gly Asp

180 185 190

Leu Gin Gly Val Thr Ala Lys Thr Lys Asn Gly Thr Leu Val Gly Cys

195 200 205

Leu Leu Asn Gin Ser Thr Ser Thr Phe Lys Ser 210 215

(2) INFORMATION FOR SEQ ID NO:333:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 80 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO-.333:

Met Ser Gin Glu Phe Leu Ala Arg Ile Leu Glu Gin Lys Ala Arg Glu

1 5 10 15

Val Glu Gin Met Lys Leu Glu Gin Ile Gin Pro Leu Arg Gin Thr Tyr

20 25 30

Arg Leu Ala Glu Phe Leu Lys Asn His Gin Asp Arg Leu Gin Val Ile

35 40 45

Ala Glu Val Lys Lys Ala Ser Pro Ser Phe Gly Glu Ile Ser Ile Ser

50 55 60

Met Trp Ile Leu Cys Asn Arg Pro Arg Leu Met Lys Lys Thr Glu Gin 65 70 75 80

(2) INFORMATION FOR SEQ ID NO:334:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 91 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:334:

Met Ser Ser Phe Thr Pro Glu Asp Leu Gly Met Glu Gly Tyr Ala Met

1 5 10 15

Glu Asp Ile Arg Gly Gly Asn Ala Gin Glu Asn Ala Glu Ile Leu Leu

20 25 30

Ser Val Leu Lys Asn Glu Ala Ser Pro Phe Leu Glu Thr Thr Val Leu

35 40 45

Asn Ala Gly Leu Gly Phe Tyr Ala Asn Gly Lys Ile Asp Ser Ile Lys

50 55 60

Glu Gly Val Ala Leu Ala Arg Gin Val Ile Ala Arg Gly Lys Ala Leu 65 70 75 80

Glu Lys Leu Arg Leu Leu Gin Glu Tyr Gin Lys 85 90

(2) INFORMATION FOR SEQ ID NO:335:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 160 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:335:

Met Ile Tyr Thr Val Thr Leu Asn Pro Ser Ile Asp Tyr Ile Val Arg

1 5 10 15

Leu Asp Gin Val Lys Val Gly Ser Val Asn Arg Met Asp Ser Asp Asp

20 25 30

Lys Phe Ala Gly Gly Lys Gly Ile Asn Val Ser Arg Val Leu Lys Arg

35 40 45

Leu Asn Ile Ser Asn Thr Ala Thr Gly Phe lie Gly Gly Phe Thr Gly

50 55 60

Lys Phe Xaa Xaa Asp Thr Leu Ala Glu Glu Glu Ile Glu Xaa Arg Phe 65 70 75 80

Val Gin Val Ala Glu Asp Thr Arg Ile Asn Val Lys Ile Xaa Ala Asp

85 90 95

Gin Glu Thr Glu Ile Asn Gly Thr Gly Pro Thr Val Glu Pro Val Lys 100 105 110 Leu Glu Glu Leu Lys Ala Ile Leu Ser Ser Leu Thr Ala Glu Asp Thr

115 120 125

Val Val Phe Ala Gly Ser Ser Ala Lyε Aεn Leu Gly Asn Val Ile Tyr

130 135 140

Lys Gly Phe Asn Leu Leu Asp Ala Pro Asp Trp Cys Ala Ser Gly Leu

145 150 155 160

(2) INFORMATION FOR SEQ ID NO:336:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:336:

Met Met Gin Val Tyr Phe Asp Gin Gly Ile Tyr Asn Lys Lys Ala Val

1 5 10 15

Phe Glu Val Tyr Phe Arg Gin Gin Pro Phe Lys Asn Gly Tyr Ala Val

20 25 30

Phe Ala Gly Leu Glu Arg Ile Val Asn Tyr Leu Glu Asp Leu Arg Phe

35 40 45

Ser Asp Ser Asp Ile Ala Tyr Leu Glu Ser Leu Gly Tyr His Gly Ala

50 55 60

Phe Leu Asp Tyr Leu Arg Aεn Phe Lys Leu Glu Leu Thr Val Arg Ser 65 70 75 80

Ala Gin Glu Gly Asp Leu Val Phe Ala Asn Glu Pro Ile Val Gin Val

85 90 95

Glu Gly Pro Leu Ala Gin Cys Gin Leu Val Glu Thr Ala Leu Leu Asn

100 105 110

Ile Val Asn Tyr Gin Thr Leu Val Ala Thr Lys Ala Ala Pro Tyr Pro

115 120 125

Phe Gly Tyr Arg Lys 130

(2) INFORMATION FOR SEQ ID NO: 337:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 84 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:337:

Met Lys Ile Ile Ile Gin Arg Val Lys Lys Ala Gin Val Ser Ile Glu

1 5 10 15

Gly Gin Ile Gin Gly Lys Ile Asn Gin Gly Leu Leu Leu Leu Val Gly

20 25 30

Val Gly Pro Glu Asp Gin Glu Glu Asp Leu Asp Tyr Ala Val Arg Lys

35 40 45

Leu Val Aεn Met Arg Ile Phe Ser Asp Val Glu Gly Lys Met Asn Leu

50 55 60

Ser Val Lys Asp Ile Glu Gly Glu Ile Leu Ser Ile Leu Ser Leu Pro 65 70 75 80

Leu Cys Gly Tyr

(2) INFORMATION FOR SEQ ID NO:338:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

( i) SEQUENCE DESCRIPTION: SEQ ID NO:338:

Met Ile Lys Gly Thr Ile Lys Thr Val Ser Ile Met Ala Ala Thr Ser

1 5 10 15

Gly Phe Leu Leu Tyr Asn Glu Val Phe Phe Leu Thr Asn Gly Ala Ala

20 ^' 25 30

Gly Thr Lys Ser Ile Ser Phe Val Ile Arg Glu Leu Ala Val Ala Ser

35 40 45

Ser Arg Thr Gin Tyr Ala Arg Ala Asn Thr Ile Gly Val lie Gin Ile

50 55 60

Leu Gly Gly Met Leu Ile Ile Val Cys Ile Asn Ile Leu Phe Arg Glu 65 70 75 80

Arg Lys Arg Leu Lys Gly Gly Lys 85 (2) INFORMATION FOR SEQ ID NO:339:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 147 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 339:

Met Gly Phe Gly Ile Pro Ala Ala Ile Gly Ala Lys Ile Ala Asn Pro

1 5 10 15

Asp Lys Glu Val Val Leu Phe Val Gly Asp Gly Gly Phe Gin Met Thr

20 25 30

Asn Gin Glu Leu Ala Ile Leu Asn Ile Tyr Lys Val Pro Ile Lys Val

35 40 45

Val Met Leu Asn Asn His Ser Leu Gly Met Val Arg Gin Trp Gin Glu

50 55 60

Ser Phe Tyr Glu Gly Arg Thr Ser Glu Ser Val Phe Asp Thr Leu Pro 65 70 75 80

Asp Phe Gin Leu Met Ala Gin Ala Tyr Gly Ile Lys Asn Tyr Lys Phe

85 90 95

Asp Asn Pro Glu Thr Leu Ala Gin Asp Leu Glu Ala Thr Thr Glu Asp

100 105 110

Val Pro Met Leu Ile Glu Val Asp Ile Ser Arg Lys Glu Gin Val Leu

115 120 125

Pro Met Val Pro Ala Gly Lys Ser Aεn Hiε Glu Met Leu Gly Val Lys

130 135 140

Phe His Ala 145

(2) INFORMATION FOR SEQ ID NO: 340:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 61 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:340: Met Trp Leu Pro Leu Asp Arg Asn Asn Lys Gly Gin Asn Ile Ala Gly

1 5 10 15

Ala Arg Gin Ala Ala Glu Gly Ile Phe Gly Val Asp Ala Ser Gin Leu

20 25 30

Thr Val Pro Gin Ala Ala Phe Leu Ala Gly Leu Pro Gin Ser Pro Ile

35 40 45

Thr Tyr Ser Pro Tyr Glu Asn Thr Gly Glu Leu Lys Asn 50 55 60

(2) INFORMATION FOR SEQ ID NO:341:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 107 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:341:

Met Tyr Leu Gly Asp Leu Met Glu Lys Ala Glu Cys Gly Gin Phe Ser

1 5 10 15

Ile Leu Ser Phe Leu Leu Gin Glu Ser Gin Thr Thr Val Lys Ala Val

20 25 30

Met Glu Glu Thr Gly Phe Ser Lys Ala Thr Leu Thr Lys Tyr Val Thr

35 40 45

Leu Leu Asn Asp Lys Ala Leu Asp Ser Gly Leu Glu Leu Thr Ile His

50 55 60

Ser Glu Asp Glu Asn Leu Arg Leu Ser Ile Gly Ala Ala Thr Lys Gly 65 70 75 80

Arg Asp Ile Pro Glu Leu Val Phe Trp Ile Val Leu Leu Asn Thr Arg

85 90 95

Phe Trp Phe Ile Phe Ser Thr Thr Asn Ser Phe 100 105

(2) INFORMATION FOR SEQ ID NO:342:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 129 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:342:

Met Lys Glu Ile Ile Glu Lys Leu Ala Lys Phe Glu Asn Leu Ser Gly

1 5 10 15

Val Glu Met Thr Asp Val Ile Glu Arg Ile Val Thr Gly Arg Val Thr

20 25 30

Glu Ala Gin Ile Ala Ser Leu Leu Leu Ala Leu Lys Met Lys Gly Glu

35 40 45

Thr Pro Glu Glu Arg Thr Ala Ile Ala Gin Val Met Arg Gly His Ala

50 55 60

Gin His Ile Pro Thr Glu Ile His Aεp Ala Met Aεp Aεn Cys Gly Thr 65 70 75 80

Gly Gly Asp Lys Ser Phe Ser Phe Asn Ile Ser Thr Thr Ala Ala Phe

85 90 95

Val Leu Ala Gly Gly Gly Ile His Met Ala Lys His Gly Asn Arg Ser

100 105 110

Ile Ser Ser Lys Ser Gly Ser Ala Asp Ser Xaa Aεn Leu Gly Aεn Gin

115 120 125

Ser

(2) INFORMATION FOR SEQ ID NO:343:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 139 amino acids

(B) TYPE: ammo acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:343:

Met Asn Val Gin Met Ser Ser Lys Thr Asn Ile Leu Arg Ala His Ala

1 5 10 15

Glu Met Gin Asn Ile Gin Arg Arg Ala Asn Glu Glu Arg Gin Asn Leu

20 25 30

Gin Arg Tyr Arg Ser Gin Asp Leu Ala Lys Ala Ile Leu Pro Ser Leu

35 40 45

Asp Asn Leu Glu Arg Ala Leu Ala Val Glu Gly Leu Thr Asp Asp Val 50 55 60 Lys Lys Gly Leu Gly Met Val Gin Glu Ser Leu Ile His Ala Leu Lys 65 70 75 80

Glu Glu Gly Ile Glu Glu Ile Ala Ala Asp Gly Glu Phe Asp His Asn

85 90 95

Tyr His Met Ala Ile Gin Thr Leu Pro Ala Aεp Asp Asp His Pro Val

100 105 110

Asp Thr Ile Ala Gin Val Phe Gin Lyε Gly Tyr Lyε Leu Hiε Aεp Arg

115 120 125

Ile Leu Arg Pro Ala Met Val Val Val Tyr Asn 130 135

(2) INFORMATION FOR SEQ ID NO:344:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 53 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:344:

Met Ser Asn Lys Ser Tyr Ser Lys Phe Gin Glu Glu Val Ser Leu Lys

1 5 10 15

Tyr Gly Phe Ile Gly Leu Lys Leu Asp Lys Leu Ser Leu Thr Ala Glu

20 25 30

Val Ser Glu Glu Phe His Ser Glu Ile Leu Ser Gly Asn Phe Thr Leu

35 40 45

Tyr Asp Ile Ser Val 50

(2) INFORMATION FOR SEQ ID NO:345:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 55 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:345: Met His Phe Asp Lys Ser Lys Phe Gly Ala Val Phe Ser Ala Pro Gly

1 5 10 15

Leu Tyr Glu Val Glu Val Ile Asn Asn Ala Ser Phe Gly Gin Asn Ala

20 25 30

Gin Tyr Glu Val Ile Gin Ser Arg Lys Leu Gly Thr Phe Ala Glu Leu

35 40 45

Ile Glu Met Ala Lys Ile Lys 50 55

(2) INFORMATION FOR SEQ ID NO:346:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 114 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 346:

Met Ile Gin Ala Val Phe Glu Arg Ala Glu Asp Gly Glu Leu Arg Ser

1 5 10 15

Ala Glu Ile Thr Gly His Ala Glu Ser Gly Glu Tyr Gly Leu Asp Val

20 25 30

Val Cys Ala Ser Val Ser Thr Leu Ala Ile Asn Phe Ile Asn Ser Ile

35 40 45

Glu Lys Phe Ala Gly Tyr Glu Pro lie Leu Glu Leu Asn Glu Asp Glu

50 55 60

Gly Gly Tyr Leu Met Val Glu Ile Pro Lys Asp Leu Pro Ser His Gin 65 70 75 80

Arg Glu Met Thr Gin Leu Phe Phe Glu Ser Phe Phe Leu Gly Met Ala

85 90 95

Asn Leu Ser Glu Asn Ser Ser Glu Phe Val Gin Thr Arg Val Ile Thr

100 105 110

Glu Asn

(2) INFORMATION FOR SEQ ID NO:347:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 109 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:347:

Met Thr Ala Ile Ser Met Lys Trp Leu Asn Asp Tyr Ile Trp Pro Ala

1 5 10 15

Glu Ser Glu Phe Thr Pro Asp Met Thr Thr Asn Ala Val Lys Glu Ala

20 25 30

Leu Thr Glu Met Leu Gin Ser Gly Thr Thr Thr Phe Asn Asp Met Tyr

35 40 45

Asn Pro Asn Gly Val Asp Ile Gin Gin Ile Tyr Gin Val Val Lys Thr

50 55 60

Ser Lys Met Arg Cys Tyr Phe Ser Pro Thr Leu Phe Ser Ser Glu Thr 65 70 75 80

Glu Thr Thr Ala Glu Thr Ile Ser Arg Thr Arg Ser Ile Ile Asp Glu

85 90 95

Ile Leu Lys Tyr Lys Asn Pro Lys Phe Gin Gly Leu Trp 100 105

(2) INFORMATION FOR SEQ ID NO: 348:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:348:

Met Val Arg Glu Ser Ala Glu Ser Ala Gly Phe Phe Leu Glu Thr His

1 5 10 15

Met Val Gin Gly Glu Trp Asn Thr Cys Val Phe Lys Lys Thr Lys Asp

20 25 30

Ile Ser Gly Val Ile Gly Gly 35

(2) INFORMATION FOR SEQ ID NO:349:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 49 amino acids (B) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:349:

Met Thr Val Asp Arg Glu Gly Phe Glu Ala Ala Met Lys Glu Gin Gin

1 5 10 15

Glu Arg Ala Arg Ala Ser Ala Val Lys Gly Gly Ser Met Gly Met Gin

20 25 30

Asn Gly Asn Ser Ser Lys His His Cys Arg Lys Cys Leu Gin Leu Gin

35 40 45

Cys

(2) INFORMATION FOR SEQ ID NO:350:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 125 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:350:

Met Lys Ala Gin Leu Val Pro Ser Arg Ser Lys Tyr Leu Ile Asn Asp

1 5 10 15

Asn Thr Val Val Leu Phe Phe Gly Thr Arg Thr Asp Tyr Thr Arg Lys

20 25 30

Tyr Asp Leu Asp Leu Val Arg Glu Val Ala Gly Asp Gin Ile Ala Arg

35 40 45

Arg Val Val Leu Leu Ser Asp Gin Ala Phe Gly Leu Glu Asn Val Lys

50 55 60

Glu Val Ala Leu Gly Cys Gly Gly Val Leu Asn Asp Ile Tyr Arg Val 65 70 75 80

Phe Pro Tyr Ile Val Tyr Ala Gin Leu Phe Ala Leu Leu Thr Ser Leu

85 90 95

Lys Val Glu Asn Lys Pro Asp Thr Pro Ser Pro Thr Gly Thr Val Asn 100 105 110 Arg Val Val Gin Gly Val Ile Ile His Glu Tyr Gin Lys 115 120 125

(2) INFORMATION FOR SEQ ID NO:351:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 236 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:351:

Met Ala Val Asn Asn Glu Ile Gly Ser Ile Gin Xaa Ile Glu Ala Ile

1 5 10 15

Ser Glu Phe Leu Ala Asp Lys Pro Thr Ile Ser Phe His Val Asp Ala

20 25 30

Val Gin Ala Leu Ala Lys Ile Pro Thr Glu Lys Tyr Leu Thr Glu Arg

35 40 45

Val Asp Cys Ala Thr Phe Ser Ser His Lys Phe His Gly Val Arg Gly

50 55 60

Val Gly Phe Val Tyr Ile Lys Ser Gly Lys Lys Ile Thr Pro Leu Leu 65 70 75 80

Thr Gly Gly Gly Gin Glu Arg Asp Tyr Arg Ser Thr Thr Glu Asn Val

85 90 95

Ala Gly Ile Ala Ala Thr Ala Lys Ala Leu Arg Leu Ser Met Glu Lys

100 105 110

Leu Asp Ile Phe Arg Ser Lys Thr Gly Gin Met Lys Ala Val Ile His

115 120 125

Gin Ala Leu Leu Asn Tyr Pro Asp Ile Phe Val Phe Ser Asp Glu Glu

130 135 140

Asp Phe Ala Pro His Ile Leu Thr Phe Gly Ile Lys Gly Val Arg Gly 145 150 155 160

Glu Val Ile Val His Ala Phe Glu Asp Tyr Asp Ile Phe Ile Ser Thr

165 170 175

Thr Ser Ala Cys Ser Ser Lys Ala Gly Lys Pro Ala Gly Thr Leu Ile

180 185 190

Ala Met Gly Val Asp Lys Asp Lys Ala Lys Ser Ala Val Arg Leu Ser

195 200 205

Leu Asp Leu Glu Asn Asp Met Ser Gin Val Glu Gin Phe Leu Thr Lys 210 215 220 Leu Lys Leu Ile Tyr Asn Gin Thr Arg Lys Val Arg 225 230 235

(2) INFORMATION FOR SEQ ID NO:352:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 166 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:352:

Met Leu Val Thr Gly Ala Ile Leu Gly Val Asn Val His Ile Phe Ser

1 5 10 15

Pro Lys Glu Leu Phe Pro Glu Lys Glu Ile Val Glu Leu Ala Glu Gly

20 25 30

Phe Ala Lys Glu Ser Gly Ala His Val Leu Ile Thr Glu Asp Ala Asp

35 40 45

Glu Ala Val Lys Asp Ala Asp Val Leu Tyr Thr Asp Val Trp Val Ser

50 55 60

Met Gly Glu Glu Asp Lys Phe Ala Glu Arg Val Ala Leu Leu Lys Pro 65 70 75 80

Tyr Gin Val Asn Met Asp Leu Val Lys Lys Ala Gly Asn Glu Asn Leu

85 90 95

Ile Phe Leu His Cys Leu Pro Ala Phe Hiε Asp Thr His Thr Val Tyr

100 105 110

Gly Lys Asp Val Ala Glu Lys Phe Gly Val Glu Glu Met Glu Val Thr

115 120 125

Asp Glu Val Phe Arg Ser Lys Tyr Ala Arg His Phe Asp Gin Ala Glu

130 135 140

Asn Arg Met His Thr Ile Lys Ala Val Met Ala Ala Thr Leu Gly Asn 145 150 155 160

Leu Tyr Ile Pro Lys Val 165

(2) INFORMATION FOR SEQ ID NO:353:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 143 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:353:

Met Arg Leu Glu Gin Asp Cys Pro Val Phe Leu Lys Ile Lys Glu Lys

1 5 10 15

Asp Met Ala Ser Lys Met Leu His Thr Cys Leu Arg Val Glu Asn Leu

20 25 30

Glu Lys Ser Ile Ala Phe Tyr Gin Asp Ala Phe Gly Phe Lys Glu Leu

35 40 45

Arg Arg Arg Asp Phe Pro Asp His Ala Phe Thr Ile Val Tyr Leu Gly

50 55 60

Leu Glu Gly Asp Asp Tyr Glu Leu Glu Leu Thr Tyr Asn Tyr Asp Hiε 65 70 75 80

Gly Pro Tyr Val Val Gly Asp Gly Phe Ala His Ile Ala Leu Ser Thr

85 90 95

Pro Asp Leu Glu Ala Leu His Gin Glu His Ser Thr Lys Gly Tyr Glu

100 105 110

Val Thr Glu Pro Asn Gly Leu Pro Gly Thr Ala Pro Asn Tyr Tyr Phe

115 120 125

Val Lys Asp Pro Asp Gly Tyr Lys Val Glu Val Ile Arg Glu Lys 130 135 140

(2) INFORMATION FOR SEQ ID NO:354:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 173 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:354:

Met Asp His Thr Ile Phe Cys Val Gly Tyr Arg Val Met Gin Lys Asp

1 5 10 15

Leu Glu Gly Thr Leu Asp Ala Glu Lys Leu Lys Ala Ala Gly Val Pro

20 25 30

Phe Gly Pro Leu Phe Gly Lys Ile Lys Asn Gly Gin Asp Leu Val Leu 35 40 45 Glu Asp Gly Thr Glu Ile Lys Ala Ala Asp Tyr Ile Ser Ala Pro Arg

50 55 60

Pro Gly Lys Ile Ile Thr Ile Leu Gly Asp Thr Arg Lys Thr Asp Ala 65 70 75 80

Ser Val Arg Leu Ala Val Asn Ala Asp Val Leu Val His Glu Ser Thr

85 90 95

Tyr Gly Lys Gly Asp Glu Lys Ile Ala Arg Asn His Gly His Ser Thr

100 105 110

Asn Met Gin Ala Ala Gin Val Ala Val Glu Ala Gly Ala Lys Arg Leu

115 120 125

Leu Leu Asn His Ile Ser Ala Arg Phe Leu Ser Lys Asp Ile Ser Lys

130 135 140

Leu Lys Lys Asp Ala Ala Thr Ile Phe Glu Asn Val His Val Val Lys 145 150 155 160

Asp Leu Glu Lys Met Glu Ile Tyr Gin Ser Gin Lys Gly 165 170

(2) INFORMATION FOR SEQ ID NO: 355:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:355:

Met Ile Gin Pro Ala Ser Leu Glu Glu Leu Ala Ser Leu Val Glu Lys

1 5 10 15

Ala Gly Lys Lys Val Phe Leu Phe Val Ala Asp Trp Cys Gly Asp Cys

20 25 30

Arg Tyr Ile Tyr Pro Ala Leu Pro Glu Ile Glu Glu Thr Asn Pro Glu

35 40 45

Phe Thr Phe Ile Arg Met Asp Arg Asp Gin Tyr Met Asp Leu Ala Lys

50 55 60

Leu Trp Asp Val Tyr Gly Ile Pro Ser Leu Val Val Leu Glu Lys Asp 65 70 75 80

Lys Glu Ile Gly Arg Phe Val Asn Arg Asp Arg Lyε Ser Lyε Glu Gin

85 90 95

Ile Aεn Asp Phe Leu Ala Gly Leu Lys 100 105 (2) INFORMATION FOR SEQ ID NO:356:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 52 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:356:

Met Arg Leu Gly Leu Leu Gin Val Leu Arg Leu Pro Lys Ala Phe Gin

1 5 10 15

Leu Ile Phe Ile Gin Asp Lys Gly His Gly Asp Val Ser Ser Phe Thr

20 25 30

Ala Ser Cys Val Thr Gly Pro Trp Ala Phe Lys Leu Val Gly Lys Gin

35 40 45

Gly Asn Ile His 50

(2) INFORMATION FOR SEQ ID NO:357:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:357:

Met Lys Thr Arg Lys Ile Pro Leu Arg Lys Ser Val Val Ser Asn Glu

1 5 10 15

Val Ile Asp Lys Arg Asp Leu Leu Arg Ile Val Lys Asn Lys Glu Gly

20 25 30

Gin Val Phe Ile Asp Pro Thr Gly Lys Ala Asn Gly Arg Gly Ala Tyr

35 40 45

Ile Lys Leu Asp Asn Ala Glu Ala Leu Glu Ala Lys Lys Lys Lys Val

50 55 60

Phe Asn Arg Ser Phe Ser Met Glu Val Glu Glu Ser Phe Tyr Asp Glu 65 70 75 80 Leu Ile Ala Tyr Val Asp His Lys Val Lys Arg Arg Glu Leu Gly Leu

85 90 95

Glu

(2) INFORMATION FOR SEQ ID NO:358:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 159 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:358:

Met Arg Val Ala Tyr Phe Lys Val His His Pro Ile Tyr Tyr Tyr Cys

1 5 10 15

Ala Tyr Phe Ser Ile Arg Ala Lys Ala Phe Asp Ile Lys Thr Met Gly

20 25 30

Ala Gly Leu Glu Val Ile Lys Arg Arg Met Glu Glu Ile Ser Glu Lys

35 40 45

Arg Lys Asn Asn Glu Ala Ser Asn Val Glu Ile Asp Leu Tyr Thr Thr

50 55 60

Leu Glu Ile Val Asn Glu Met Trp Glu Arg Gly Phe Lys Phe Gly Lys 65 70 75 80

Leu Asp Leu Tyr Cys Ser Gin Thr Thr Glu Phe Leu Ile Asp Gly Asp

85 90 95

Thr Leu Ile Pro Pro Phe Val Ala Met Asp Gly Leu Gly Glu Asn Val

100 105 110

Ala Lys Gin Leu Val Arg Ala Arg Glu Glu Gly Glu Phe Leu Ser Lys

115 120 125

Thr Glu Leu Arg Lys Arg Gly Gly Leu Ser Ser Thr Leu Val Glu Lys

130 135 140

Met Asp Glu Met Gly Ile Leu Gly Asn Met Pro Glu Ile Thr Ser 145 150 155

(2) INFORMATION FOR SEQ ID NO:359:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 146 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:359:

Met Ser Ser Lys Ile Ser Ile Gly Gin Leu Ile Thr Phe Asn Thr Leu

1 5 10 15

Leu Ser Tyr Phe Thr Thr Pro Met Glu Asn Ile Ile Asn Leu Gin Thr

20 25 30

Lys Leu Gin Ser Ala Lys Val Ala Asn Asn Arg Leu Asn Glu Val Tyr

35 40 45

Leu Val Glu Ser Glu Phe Gin Val Gin Glu Asn Pro Val His Ser His

50 55 60

Phe Leu Met Gly Asp Ile Glu Phe Asp Asp Leu Ser Tyr Lys Tyr Gly 65 70 75 80

Phe Gly Arg Asp Thr Leu Thr Asp Ile Asn Leu Thr Ile Lys Gin Gly

85 90 95

Asp Lys Val Ser Leu Val Gly Val Ser Gly Ser Gly Lys Thr Thr Leu

100 105 110

Ala Lys Met Ile Val Asn Phe Phe Glu Pro Tyr Lys Gly His Ile Ser

115 120 125

Ile Asn His Gin Asp Ile Lys Asn Ile Asp Lys Lys Ser Leu Ala Pro

130 135 140

Ser Tyr 145

(2) INFORMATION FOR SEQ ID NO:360:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 31 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:360:

Met Arg Gin Ala Pro Ala Leu Ala Gin Ala Asn Ile Glu Arg Val Val

1 5 10 15

Val His Lys lie Ser Lys Val Trp Glu Phe His Phe Arg Ile Phe

20 25 30 ( 2 ) INFORMATION FOR SEQ ID NO : 361 :

( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 123 amino acids

(B) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 361:

Met Gin Thr Gly Trp Gin Tyr Leu Gly Asn Lys Trp Tyr Tyr Leu Arg

1 5 10 15

Ser Ser Gly Ala Met Ala Thr Gly Trp Tyr Gin Glu Gly Thr Thr Trp

20 25 30

Tyr Tyr Leu Asp Gin Pro Asn Gly Asp Met Lys Thr Gly Trp Gin Asn

35 40 45

Leu Gly Asn Lys Trp Tyr Tyr Leu Arg Ser Ser Gly Ala Met Ala Thr

50 55 60

Gly Trp Tyr Gin Glu Gly Thr Thr Trp Tyr Tyr Leu Asp Gin Pro Asn 65 70 75 80

Gly Asp Met Lys Thr Gly Trp Gin Asn Leu Gly Asn Lys Trp Tyr Tyr

85 90 95

Leu Arg Ser Ser Gly Ala Met Ala Thr Gly Trp Tyr Gin Asp Gly Ser

100 105 110

Thr Trp Tyr Tyr Leu Asn Ala Val Met Glu Ile 115 120

(2) INFORMATION FOR SEQ ID NO: 362:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 121 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:362:

Met Lys Trp Gly Ser Arg Ile Leu Leu Gly Leu Thr Pro Lys Ser Leu

1 5 10 15 Arg Tyr Arg Ile Trp Lys Lys Ala Glu Lys Glu Met Thr Lys Tyr Asp

20 25 30

Leu Ala Asp Cys Asp Gly Ile Thr Glu Leu Cys Ser Gly Pro Gly Tyr

35 40 45

Met Arg Asn Lys Tyr Pro Ile Thr Ser Phe Glu Aεp Asn Leu Phe Leu

50 55 60

Pro Phe Glu Gly Thr Glu Met Pro lie Pro Ile Gly Tyr Asp Val Tyr 65 70 75 80

Leu Arg Thr Ala Phe Gly Asp Tyr Met Thr Pro Pro Pro Ala Asp Lys

85 90 95

Gin Val Pro His Gin Asp Ala Val Ile Ala Asp Met Asp Lys Ser Tyr

100 105 110

Thr Glu Tyr Lys Gly Glu Tyr Gly Gly 115 120

(2) INFORMATION FOR SEQ ID NO:363:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:363:

Met Phe Pro Asp Ser Ile Asp Thr Met His Gin Ala Asn Glu Phe Ile

1 5 10 15

Ala Leu Asp Asp Leu Phe Arg Ala Ala Ala Ile Tyr Ala Glu Ala Ile

20 25 30

Tyr Glu Leu Ile Lys 35

(2) INFORMATION FOR SEQ ID NO:364:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 130 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364:

Met Asp Glu Leu Gin Lys Arg Asn Leu Leu Gly Phe Val Phe Gin Asp

1 5 10 15

Phe Gin Leu Phe Pro His Leu Ser Val Leu Glu Asn Leu Thr Leu Ser

20 25 30

Pro Val Lys Thr Met Gly Met Lys Gin Glu Glu Ala Glu Lys Lys Ala

35 40 45

Ser Gly Leu Leu Glu Gin Leu Gly Leu Gly Gly His Ala Glu Ser Tyr

50 55 60

Pro Phe Ser Leu Ser Gly Gly Gin Lys Gin Arg Val Ala Leu Ala Arg 65 70 75 80

Ala Met Met Ile Asp Pro Glu Ile Ile Gly Tyr Asp Glu Pro Thr Ser

85 90 95

Ala Leu Asp Pro Glu Leu Arg Leu Glu Val Glu Lys Leu Ile Leu Gin

100 105 110

Asn Arg Glu Leu Gly Met Thr His Ile Val Val Thr His Asp Leu Gin

115 120 125

Phe Gly 130

(2) INFORMATION FOR SEQ ID NO:365:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 39 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:365:

Met Tyr Gly Ala Asn Ser Glu Arg Leu Lys Glu Ser Leu Arg Ile Ser

1 5 10 15

Leu Ser Pro Gin Asn Thr Val Glu Asp Leu Gin Thr Leu Ala Lys Thr

20 25 30

Leu Lys Glu Ile Ile Gly Gly 35

(2) INFORMATION FOR SEQ ID NO:366:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:366:

Met lie Ala Arg Ser Tyr Gin Glu Met Asp Asp Leu Asp Thr Ala Tyr

1 5 10 15

Glu His Tyr Gin Glu Leu Thr Gly Asp Leu Lys Asp Asn Pro Glu Phe

20 25 30

Leu Glu His Tyr Ile Tyr Leu Leu Arg 35 40

(2) INFORMATION FOR SEQ ID NO:367:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 137 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 367:

Met Lys His Phe Asp Thr Ile Val Ile Gly Gly Gly Pro Ala Gly Met

1 5 10 15

Met Ala Thr Ile Ser Ser Ser Phe Tyr Gly Gin Lys Thr Leu Leu Ile

20 25 30

Glu Lys Aεn Arg Lys Leu Gly Lys Lys Leu Ala Gly Thr Gly Gly Gly

35 40 45

Arg Cys Asn Val Thr Asn Asn Gly Ser Leu Asp Asn Leu Leu Ala Gly

50 55 60

Ile Pro Gly Asn Gly Arg Phe Leu Tyr Ser Val Phe Ser Gin Phe Asp 65 70 75 80

Asn His Asp Ile Ile Asn Phe Phe Thr Glu Asn Gly Val Lyε Leu Lyε

85 90 95

Val Glu Aεp Hiε Gly Arg Val Phe Pro Ala Ser Asp Lys Ser Arg Thr

100 105 110

Ile Ile Glu Ala Leu Glu Lys Lyε Ile Thr Glu Leu Gly Gly Gin Val 115 120 125 Ala Thr Pro Asn Arg Asn Arg Phe Cys 130 135

(2) INFORMATION FOR SEQ ID NO:368:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 96 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:368:

Met Thr Leu Ala Lys Asp lie Ala Ser His Leu Leu Lys Ile Gin Ala

1 5 10 15

Val Tyr Leu Lys Pro Glu Glu Pro Phe Thr Trp Ala Ser Gly Ile Lyε

20 25 30

Ser Pro Ile Tyr Thr Asp Asn Arg Val Thr Leu Ala Tyr Pro Glu Thr

35 40 45

Arg Thr Leu Ile Glu Asn Gly Phe Val Glu Ala Ile Lys Glu Ala Phe

50 55 60

Pro Glu Val Glu Val Ile Ala Gly Thr Ala Thr Ala Gly Ile Pro His 65 70 75 80

Gly Ala Ile Ile Ala Asp Lys Met Asp Leu Pro Phe Ala Tyr Ile Pro 85 90 95

(2) INFORMATION FOR SEQ ID NO:369:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 93 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 369:

Met Val Lys Val Leu Ala Ala Cys Gly Asn Gly Met Gly Ser Ser Met

1 5 10 15

Val Ile Lys Met Lys Val Glu Asn Ala Leu Arg Lys Leu Asn Gin Thr 20 25 30 Asp Phe Thr Val Asn Ser Cys Ser Val Gly Glu Ala Lys Gly Leu Ala

35 40 45

Val Gly Tyr Asp Ile Val Ile Ala Ser Leu His Leu Ile Gin Glu Leu

50 55 60

Glu Gly Arg Thr Asn Gly Lys Leu lie Gly Leu Asp Asn Leu Met Asp 65 70 75 80

Asp Lys Glu Ile Thr Glu Lys Leu Ser Gin Ala Ile Gin 85 90

(2) INFORMATION FOR SEQ ID NO:370:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 142 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 370:

Met Ser Met Phe Leu Asp Thr Ala Lys Ile Lys Val Lys Ala Gly Asn

1 5 10 15

Gly Gly Asp Gly Met Val Ala Phe Arg Arg Glu Lys Tyr Val Pro Asn

20 25 30

Gly Gly Pro Trp Gly Gly Asp Gly Gly Arg Gly Gly Asn Val Val Phe

35 40 45

Val Val Asp Glu Gly Leu Arg Thr Leu Met Asp Phe Arg Tyr Asn Arg

50 55 60

His Phe Lys Ala Asp Ser Gly Glu Lys Gly Met Thr Lys Gly Met His 65 70 75 80

Gly Arg Gly Ala Glu Asp Leu Arg Val Arg Val Pro Gin Gly Thr Thr

85 90 95

Val Arg Asp Ala Glu Thr Gly Lys Val Leu Thr Asp Leu Ile Glu His

100 105 110

Gly Gin Glu Phe Ile Val Ala His Gly Gly Pro Trp Trp Thr Trp Lys

115 120 125

Tyr Ser Phe Arg Asp Thr Lys Lys Ser Cys Thr Gly Asn Leu 130 135 140

(2) INFORMATION FOR SEQ ID NO:371:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 210 amino acidε (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:371:

Met Met Lys Gly Glu Met Thr Phe Lys Gin Val His Tyr Lys Tyr Gly

1 5 10 15

Tyr Gly Arg Asp Val Leu Ser Asp Ile Asn Leu Thr Val Pro Gin Gly

20 25 30

Ser Lys Val Ala Phe Val Gly Ile Ser Gly Ser Gly Lys Thr Thr Leu

35 40 45

Ala Lys Met Met Val Asn Phe Tyr Asp Pro Ser Gin Gly Glu Ile Ser

50 55 60

Leu Gly Gly Val Asn Leu Asn Gin Ile Asp Lys Lys Ala Leu Arg Gin 65 70 75 80

Tyr Ile Ile Tyr Leu Pro Pro Gin Pro Tyr Val Phe Asn Gly Thr Ile

85 90 95

Leu Glu Asn Leu Leu Leu Gly Ala Lys Gly Gly Asp Asp Thr Gly Lys

100 105 110

Ile Ser Leu Thr Gly Arg Ser Glu Phe Gly Ser Glu Ile Pro Lys Arg

115 120 125

Asn Ile Ser Lys Pro Pro Cys His Leu Glu Ile Tyr Gin Thr Glu Leu

130 135 140

Thr Ser Asp Gly Ala Gly Ile Ser Gly Gly Gin Arg Gin Arg Ile Ala 145 150 155 160

Leu Ala Arg Ala Leu Leu Thr Asp Ala Pro Val Leu Ile Leu Asp Glu

165 170 175

Ala Thr Asn Ser Leu Asp Ile Leu Thr Lys Lys Arg Ile Val His Tyr

180 185 190

Leu Met Ala Leu Asp Lys Thr Phe Asp Phe Hiε Cys Ser Pro Leu Asp

195 200 205

Tyr Cys 210

(2) INFORMATION FOR SEQ ID NO:372:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 73 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:372:

Met Ala Arg Phe Ile Glu Ile Asp Ala Lys Glu His Asp Arg Val Thr

1 5 10 15

Ser Gin Ile Ser His Phe Pro His Ile Leu Ala Ser Ser Leu Met Glu

20 25 30

Gin Thr Ala Val Tyr Ala Gin Glu His Glu Asn Gly Lys Ala Leu Cys

35 40 45

Gly Arg Trp Phe Ser Arg Tyr Asp Pro Asn Cys Gly Lys Arg Ala Arg

50 55 60

Asn Val Asp Leu His Ser Leu Val Gin 65 70

(2) INFORMATION FOR SEQ ID NO:373:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 149 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:373:

Met Ala His Gin Gly Gin Asp Ile Tyr Asp Phe Pro Arg Ala Met Ile

1 5 10 15

Lys Glu Asp Asn Leu Glu Phe Ser Phe Ser Gly Leu Lys Ser Ala Phe

20 25 30

Ile Asn Leu His His Asn Ala Glu Gin Lys Gly Glu Ser Leu Ser Thr

35 40 45

Glu Asp Leu Cys Ala Ser Phe Gin Ala Ala Val Leu Asp Ile Leu Met

50 55 60

Ala Lys Thr Lys Lys Ala Leu Glu Lys Tyr Pro Val Lys Thr Leu Val 65 70 75 80

Val Ala Gly Gly Val Ala Ala Asn Lys Gly Leu Arg Glu Arg Leu Ala

85 90 95

Ala Glu Val Thr Asp Val Lys Val Ile Ile Pro Pro Leu Arg Leu Cys

100 105 110

Gly Asp Asn Ala Gly Met Ile Ala Tyr Ala Ser Val Ser Glu Trp Asn 115 120 125 Lys Glu Asn Phe Ala Asn Leu Asp Leu Asn Ala Lys Pro Ser Leu Ala

130 135 140

Phe Asp Thr Met Glu 145

(2) INFORMATION FOR SEQ ID NO:374:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 91 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:374:

Met Lys Arg Ser Leu Asp Ser Arg Val Asp Tyr Ser Leu Leu Leu Pro

1 5 10 15

Val Phe Phe Leu Leu Val Ile Gly Val Val Ala Ile Tyr Ile Ala Val

20 25 30

Ser His Asp Tyr Pro Asn Asn Ile Leu Pro Ile Leu Gly Gin Gin Val

35 40 45

Ala Trp lie Ala Leu Gly Leu Val Ile Gly Phe Val Val Met Leu Phe

50 55 60

Asn Thr Glu Phe Leu Trp Lys Val Thr Pro Phe Leu Tyr Ile Phe Arg 65 70 75 80

Leu Gly Thr Tyr Asp Leu Ala Asp Cys Ile Leu 85 90

(2) INFORMATION FOR SEQ ID NO:375:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 87 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:375:

Met Pro Asp Asp Ile Ile Asp Ser Phe Trp Tyr Ile Ile Asp His Phe

1 5 10 15 Leu Lys Asn Val Phe Glu Leu Glu Glu Glu Leu Glu Phe Gin Leu Leu

20 25 30

Asn Asn Gin Gly Lyε Ile Thr Phe His Phe Ser Ser Gin His Leu Pro

35 40 45

Thr Ala Ile Asp Phe Asp Phe Asn His Pro Phe Asp Pro Arg Tyr Pro

50 55 60

Pro Arg Val Leu Val Leu Asp Met Asp Gly Arg Glu Thr Ile Leu Leu 65 70 75 80

Pro Glu Glu Asn Asp Leu Phe 85

(2) INFORMATION FOR SEQ ID NO:376:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 132 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:376:

Met Gly Lys Lys Aεp Ala Ser Ala Met His Glu Met Arg Ala Ser Phe

1 5 10 15

Ile Gin Gly Ser Ile Glu Ala Gly Hiε Thr Ala Glu Lys Ser Glu Gin

20 25 30

Val Phe Asp Val Met Glu Lys Phe Ala Gly Tyr Gly Phe Asn Arg Ser

35 40 45

His Ala Tyr Ala Tyr Ser Ala Leu Ala Phe Gin Leu Ala Tyr Phe Lys

50 55 60

Thr His Tyr Pro Ala Ile Phe Tyr Gin Val Met Leu Asn Tyr Ser Asn 65 70 75 80

Ser Asp Tyr Leu Ile Asp Ala Leu Glu Ala Gly Phe Glu Val Ala Ser

85 90 95

Leu Ser Ile Asn Thr Ile Pro Tyr His Asp Lyε Ile Ala Asn Lys Ser

100 105 110

Ile Tyr Ile Gly Leu Lys Ser Ile Lys Gly Leu Gin Gin Gly Leu Gly

115 120 125

Ala Leu Asp Tyr 130

(2) INFORMATION FOR SEQ ID NO:377: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 51 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:377:

Met Asp Lys Lys Gin Asn Leu Thr Ser Phe Gin Glu Leu Thr Thr Thr

1 5 10 15

Glu Leu Asn Gin Ile Thr Gly Gly Glu Trp Trp Glu Glu Leu Leu His

20 25 30

Glu Thr Ile Leu Ser Lys Phe Lys Ile Thr Lys Ala Leu Glu Leu Pro

35 40 45

Ile Gin Leu 50

(2) INFORMATION FOR SEQ ID NO:378:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 92 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:378:

Met His Glu Met Phe Thr Ala Ile Ala Glu Ser Asp Met Lys Lys Ala

1 5 10 15

Ala Ala Ile Gin Arg Lys Phe Ile Pro Lys Val Asn Ala Leu Phe Ser

20 25 30

Tyr Pro Ser Pro Ala Pro Val Lys Ala Ile Leu Asn Tyr Met Gly Phe

35 40 45

Glu Ala Gly Pro Thr Arg Leu Pro Leu Val Pro Ala Pro Glu Glu Asp

50 55 60

Val Lys Arg Ile lie Lys Val Val Val Asp Gly Asp Tyr Glu Ala Thr 65 70 75 80

Lys Ala Thr Val Thr Gly Val Leu Arg Pro Asp Tyr 85 90 (2) INFORMATION FOR SEQ ID NO:379:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 72 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:379:

Met Leu Asn Glu Phe Pro Ile Phe Asp Tyr Glu Asp Ile Gin Leu Ile

1 5 10 15

Pro Asn Lys Cys Val Ile Lys Ser Arg Ala Glu Ala Asp Thr Ser Val

20 25 30

Thr Leu Gly Asn His Thr Phe Lys Leu Pro Val Val Pro Ala Asn Met

35 40 45

Gin Thr Ile Leu Asp Glu Asn Val Ala Glu Gin Leu Ala Lys Gly Gly

50 55 60

Tyr Leu Tyr Thr Tyr Ala Pro Phe 65 70

(2) INFORMATION FOR SEQ ID NO:380:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:380:

Met Asp Ile Lys Leu Lys Asp Phe Glu Gly Pro Leu Asp Leu Leu Leu

1 5 10 15

His Leu Val Ser Lys Tyr Gin Met Asp Ile Tyr Asp Val Pro Ile Thr

20 25 30

Glu Val Ile Glu Gin Tyr Leu Ala Tyr Val Ser Thr Leu Gin Ala Met

35 40 45

Arg Leu Glu Val Thr Gly Glu Tyr Met Val Met Ala Ser Gin Leu Met 50 55 60 Leu Ile Lys Ser Arg Lys Leu Leu Pro Lys Val Ala Glu Val Thr Asp 65 70 75 80

Leu Gly Asp Asp Leu Glu Gin Asp Leu Leu Ser Gin Ile Glu Glu Tyr

85 90 95

Arg Lys Phe Lys Leu Leu Gly Glu His Leu Glu Ala Lys His Gin Glu

100 105 110

Thr Gly Pro Val Leu Phe Gin Ser Ala Asp Arg Val Asp Leu Arg Arg

115 120 125

Cys Gly Ala Cys Ala 130

(2) INFORMATION FOR SEQ ID NO:381:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 112 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 381:

Met Gin Ser Thr Glu Lys Lys Pro Leu Thr Ala Phe Thr Xaa Ile Ser

1 5 10 15

Thr Ile Ile Leu Leu Leu Leu Thr Val Leu Xaa Ile Phe Pro Phe Tyr

20 25 30

Trp Ile Leu Thr Gly Ala Phe Lys Ser Gin Pro Asp Thr Ile Val Ile

35 40 45

Pro Pro Gin Trp Phe Pro Lys Met Pro Thr Met Glu Asn Phe Gin Gin

50 55 60

Leu Met Val Gin Asn Pro Ala Leu Gin Trp Met Trp Asn Ser Val Phe 65 70 75 80

Ile Ser Leu Val Thr Met Phe Leu Val Cys Ala Thr Ser Ser Leu Ala

85 90 95

Gly Tyr Val Leu Ala Xaa Lys Arg Phe Tyr Gly Xaa Arg Ile Tyr Cys 100 105 110

(2) INFORMATION FOR SEQ ID NO:382:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 51 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:382:

Met Leu Phe Met Arg Asp Ser Leu Asp Ser Ile Val Glu Pro Val Leu

1 5 10 15

Asp Glu Met Gly Arg Phe Tyr Asp Trp Thr Glu Glu Glu Lys Ala Thr

20 25 30

Tyr Arg Ala Asp Val Lys Ala Ala Leu Ala Gin Asn Asp Leu Ala Glu

35 40 45

Leu Lys Asn 50

(2) INFORMATION FOR SEQ ID NO:383:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 159 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:383:

Met Lys Ile Lys Val Val Thr Val Gly Lys Leu Lys Glu Lys Tyr Leu

1 5 10 15

Lys Asp Gly Ile Ala Glu Tyr Ser Lys Arg Ile Ser Arg Phe Ala Lys

20 25 30

Phe Glu Met Ile Glu Leu Ser Asp Glu Lys Thr Pro Asp Lys Ala Ser

35 40 45

Glu Ser Glu Asn Gin Lys Ile Leu Glu Ile Glu Gly Gin Arg Ile Leu

50 55 60

Ser Lys Ile Ala Asp Arg Asp Phe Val Ile Val Leu Ala Ile Glu Gly 65 70 75 80

Lys Thr Phe Phe Ser Glu Glu Phe Ser Lys Gin Leu Glu Glu Thr Ser

85 90 95

Ile Lys Gly Xaa Ser Thr Leu Thr Phe Ile Ile Gly Gly Ser Leu Gly

100 105 110

Leu Ser Ser Ser Val Lys Asn Arg Ala Asn Leu Ser Val Ser Phe Gly 115 120 125 Arg Leu Thr Leu Pro His Gin Leu Met Arg Leu Val Leu Val Glu Gin

130 135 140

Ile Tyr Arg Ala Phe Thr Ile Gin Gin Gly Phe Pro Tyr His Lys 145 150 155

(2) INFORMATION FOR SEQ ID NO:384:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 84 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:384:

Met Gly Ile Leu Ala Trp Cys Asp Leu Val Leu Tyr Arg Leu Trp Asp

1 5 10 15

Ser Phe Met Asp Leu Gly Leu Phe Ile Aεn Asp Ala Trp Val Arg Lys

20 25 30

Lys Lys Thr Leu Asn Lys Glu Arg Lys Lys Ala Gly Lys Ala Ala Leu

35 40 45

Pro Glu Asn Arg Trp Ile Gin Leu Leu Gly Met Val Val Thr Phe His

50 55 60

Val Val Met Leu Ser Phe Leu Ile Phe Ser Gly Phe Leu Asn Asn Leu 65 70 75 80

Trp Phe Lys Lys

(2) INFORMATION FOR SEQ ID NO: 385:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:385:

Met Val Met Ala Glu Asp Gin Ala Val Arg Gin Asn Arg Leu Ala Ile 1 5 10 15 Leu Ser Gin Leu Thr Lys Lys Ala Ala Lys Phe Ala Cys Phe Asn Gin

20 25 30

Ile Asn Thr Lys 35

(2) INFORMATION FOR SEQ ID NO:386:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 49 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:386:

Met Gly Ala Gin Pro Val Gin Asp Thr Glu Thr Ser Ser Ala Leu Ile

1 5 10 15

Ser Ser His Tyr Leu Asp Glu Gin Asp Leu Ser Glu Lys Leu Lys Ser

20 25 30

Glu Leu Gin Trp Phe Glu Leu Glu Asn Lys Leu Leu Asn Leu Trp Glu

35 40 45

His

(2) INFORMATION FOR SEQ ID NO:387:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 62 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 387:

Met Asp Glu Val Thr Ile Phe Gly Ile Asn Tyr Phe Lys Glu His Tyr

1 5 10 15

Pro Glu Lys Leu Ala Glu Arg Phe Lys Gin Met Lys Ile Glu Glu Glu

20 25 30

Ala Pro Val Ile Ile Met Asp Met Thr Arg Ala Leu Gly Phe Arg Asp 35 40 45 Asp Tyr Asp Arg Phe Tyr Ser Leu Phe Arg Glu Gly Ser Pro

50 55 60

(2) INFORMATION FOR SEQ ID NO: 388:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 388:

Met Lys Val Ile Asn Gin Thr Leu Leu Glu Lys Val Ile Ile Glu Arg

1 5 10 15

Ser Arg Ser Ser His Lys Gly Asp Tyr Gly Xaa Leu Leu Leu Leu Gly

20 25 30

Gly Thr Tyr Pro Tyr Gly Val Xaa Ser Ser Trp Leu Leu

35 40 45

(2) INFORMATION FOR SEQ ID NO: 389:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 192 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 389:

Met Asn Trp Ile Leu Leu Gin Gly Leu Ile Cys Gin Arg Asp Ala Ser

1 5 10 15

Tyr Asp Met Lys Gin Asp Asp Leu Asp Lys Val Ala Asp Tyr Leu Phe

20 25 30

Lys Thr Glu Glu Trp Thr Met Tyr Glu Leu Ile Leu Phe Gly Asn Leu

35 40 45

Tyr Ser Phe Tyr Asp Val Asp Tyr Val Thr Arg Ile Gly Arg Glu Val

50 55 60

Met Glu Arg Glu Glu Phe Tyr Gin Glu Ile Ser Arg His Lys Arg Leu 65 70 75 80 Val Leu Ile Leu Ala Leu Asn Cys Tyr Gin His Cys Leu Glu His Ser

85 90 95

Ser Phe Tyr Asn Ala Asn Tyr Phe Glu Ala Tyr Thr Glu Lys Ile Ile

100 105 110

Asp Lys Gly Ile Lys Leu Tyr Glu Arg Asn Val Phe His Tyr Leu Lys

115 120 125

Gly Phe Ala Leu Tyr Gin Lys Gly Gin Cys Lys Glu Gly Cys Lys Gin

130 135 140

Met Gin Glu Thr Met His Ile Phe Asp Val Leu Gly Leu Pro Glu Gin

145 150 155 160

Val Ser Leu Leu Ser Gly Thr Leu Arg Lys Ile Cys Gin Lys Leu Ile

165 170 175

Phe Pro Asn Lys Gly Lys Asn Lys Lys Leu Leu Ser Val Leu Ile Gin 180 185 190

(2) INFORMATION FOR SEQ ID NO:390:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 47 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:390:

Met Ser Thr Val Leu Ser Trp Thr Ala Tyr Lys Thr Gin Arg Leu Glu

1 5 10 15

Met Ser Ile Leu Leu His Met lie Val Asn Gly Ile Ala Phe Cys Leu

20 25 30

Leu Ala Leu Val Val Ile Met Ser Arg Thr Leu Gly Ile Ser Val

35 40 45

(2) INFORMATION FOR SEQ ID NO:391:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 76 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:391:

Met Arg Glu Asn Asp Leu Leu Leu Ile Thr Ala Asp His Gly Asn Asp

1 5 10 15

Pro Thr Tyr Ala Gly Thr Asp His Thr Arg Glu Tyr Ile Pro Leu Leu

20 25 30

Ala Tyr Ser Pro Ala Phe Lys Gly Asn Gly Leu Ile Pro Val Gly His

35 40 45

Phe Ala Asp Ile Ser Ala Thr Val Ala Asp Asn Phe Gly Val Glu Thr

50 55 60

Ala Met Ile Gly Glu Ser Phe Leu Asp Lys Leu Val 65 70 75

(2) INFORMATION FOR SEQ ID NO:392:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 161 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:392:

Met Lys Lys Ile Phe Leu Thr Leu Leu Thr Val Ser Leu Leu Gly Gly

1 5 10 15

Ala Ser Thr Ala Val Ala Gin Asp Phe Thr Ile Ala Ala Lys His Ala

20 25 30

Ile Ala Val Glu Ala Asn Thr Gly Lyε Ile Leu Tyr Glu Lys Asp Ala

35 40 45

Thr Pro Pro Val Glu Ile Ala Ser Ile Thr Lys Leu Ile Thr Val Tyr

50 55 60

Leu Val Tyr Glu Ala Leu Glu Asn Gly Ser Ile Thr Leu Ser Thr Pro 65 70 75 80

Val Asp Ile Ser Asp Tyr Pro Tyr Gin Leu Thr Thr Asn Ser Glu Ala

85 90 95

Ser Asn Ile Pro Met Glu Ala Arg Asn Tyr Thr Val Glu Glu Leu Leu

100 105 110

Glu Ala Thr Leu Val Ser Ser Ala Asn Ser Ala Ala Ile Ala Leu Ala

115 120 125

Glu Lys Ile Ala Gly Ser Glu Lys Asp Phe Val Xaa Met Met Arg Ala 130 135 140 Lys Leu Leu Glu Trp Gly Ile Arg Ile His Cys Cys Gin Tyr Asp Arg

145 150 155 160

Ser

(2) INFORMATION FOR SEQ ID NO:393:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:393:

Met Ser Asn Ala Met Glu Gly Val Leu Tyr Phe Leu Lys Pro Asp Phe

1 5 10 15

Ser Lys Leu Thr Ser Ala Asp Leu Leu Tyr Ala Leu Gly Gin Ser Phe

20 25 30

Phe Ala Leu Ser Leu Gly Val Thr Asp Met Leu Thr Tyr Ala Ser Tyr

35 40 45

Leu Asp Lys Lys Thr Asn Leu Val Gin Ser Gly Ile Ser Ile Val Thr

50 55 60

Met Aεn lie Ser Ile Val His His Gly Arg Ser Ser His Phe Pro Ser 65 70 75 80

His Val Ser Leu Gin Tyr Pro Leu 85

(2) INFORMATION FOR SEQ ID NO:394:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 75 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:394:

Met Lys Val Ala Lys Pro Phe Trp Ala Ile Val Lys Leu Lys Ser Val

1 5 10 15 Gin His Ala Ser Met Leu Glu Asn Pro Lys Glu Met Asp Gly Leu Met

20 25 30

Lys Gin Val Glu Asn Leu Ala Leu Glu Asn Gin Gly Tyr Gin Val Glu

35 40 45

Lys Glu Asn Lys Ala Phe Glu Gin Ile Lys Asp Ser Val Ala Thr Phe

50 55 60

Gin Thr Phe Leu Thr Ile Phe Leu Tyr Gly Cys 65 70 75

(2) INFORMATION FOR SEQ ID NO:395:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 93 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:395:

Met Asp Ala Glu Val Ser Lys Aεn Leu Arg Leu Ile Leu Glu Arg Lys

1 5 10 15

Gly Met Thr Ile Leu Thr Gly Thr Lys Leu Gin Glu Ile lie Glu Glu

20 25 30

Asn Gly Gin Leu Arg Ile Lys Val Glu Gly Lys Asp Asn Ile Ile Ala

35 40 45

Ser Lys Ala Leu Leu Ser Ile Gly Arg Met Pro Asp Leu Glu Gly Ile

50 55 60

Gly Glu Val Glu Phe Glu Leu Asp Arg Gly Cys Ile Lys Val Asn Glu 65 70 75 80

Tyr Met Glu Thr Ser Val Pro Arg Ile Tyr Ala Thr Arg

85 90

(2) INFORMATION FOR SEQ ID NO:396:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 69 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:396:

Met Lys Asn Ser Ile Met Asp Thr Lys Phe Asp Arg Arg Ile Leu Leu

1 5 10 15

Leu Asn Lys Ile Ile Ile Val Phe Ile Val Leu Met Thr Leu Leu Pro

20 25 30

Leu Leu Tyr Ile Val Val Ala Ser Phe Met Asp Pro Lys Val Leu Val

35 40 45

Ser Arg Gly Ile Ser Phe Asn Pro Ala Asp Trp Thr Val Glu Gly Tyr

50 55 60

Gin Arg Val lie Gin 65

(2) INFORMATION FOR SEQ ID NO:397:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 89 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:397:

Met Val Ile Pro Glu Ala Gly Tyr Leu Tyr Ala Phe His Tyr Pro Asn

1 5 10 15

Leu Lys Gly Lys Gly Lys Glu Ala Val Gin Val Ile Tyr Asn Leu Asn

20 25 30

Leu Ala Ser Ala Lys Val Ile Gin Leu Tyr Arg Ser Leu Gly Leu Asp

35 40 45

Gly Lys Ile Gly Ile Ile Leu Asn Leu Thr Pro Ala Tyr Pro Arg Ser

50 55 60

Asn Ser Pro Glu Asp Leu Glu Ala Ser Arg Phe Thr Asp Asp Phe Phe 65 70 75 80

Asn Lys Val Phe Leu Glu Ser Ser Cys 85

(2) INFORMATION FOR SEQ ID NO:398:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 86 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:398:

Met Thr Arg Ile Ala Ser Val Ser Val Ile Arg Asn Ala Ala Phe Ile

1 5 10 15

Ala Ile Ala Leu Ser Phe Leu Gly Lys Phe Thr Ala Leu Ile Ser Thr

20 25 30

Ile Pro Asn Ala Val Leu Gly Gly Met Ser Ile Leu Leu Tyr Gly Val

35 40 45

Ile Ala Ser Asn Gly Leu Lys Val Leu Ile Lyε Glu Arg Val Asp Phe

50 55 60

Ala Gin Met Arg Asn Leu Ile Ile Ala Ser Ala Met Leu Val Leu Gly 65 70 75 80

Leu Gly Arg Ser Tyr Pro 85

(2) INFORMATION FOR SEQ ID NO:399:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 129 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:399:

Met Ser Leu Arg Glu Lys Ser Met Ser Glu Tyr Lys Leu Ser Glu Asn

1 5 10 15

Asn Trp Thr Arg Val Ala Val Phe Ala Gly Gly Asn Arg Gly His Tyr

20 25 30

Arg Thr Asp Phe Asp Ala Phe Val Gly Val Asp Arg Gly Ser Leu Trp

35 40 45

Val Leu Glu Glu Asp Leu Pro Leu Ala Leu Ala Val Gly Asp Phe Asp

50 55 60

Ser Val Thr Glu Glu Glu Arg Gin Val Ile Gin Lys Arg Ala Gin Tyr 65 70 75 80

Phe Val Gin Ala Arg Pro Glu Lys Aεp Asp Thr Asp Leu Glu Leu Ala 85 90 95 Leu Leu Thr Ile Phe Glu Gin Asn Pro Gin Ala Glu Val Thr Ile Phe

100 105 110

Gly Ala Leu Gly Gly Arg Ile Asp His Met Leu Ala Asn Val Leu Ser

115 120 125

Thr

(2) INFORMATION FOR SEQ ID NO:400:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 58 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:400:

Met Val Leu Gin Arg Asn Glu Ile Asn Glu Lys Asp Thr Trp Asp Leu

1 5 10 15

Ser Thr Ile Tyr Pro Thr Asp Gin Ala Trp Glu Glu Ala Leu Lys Asp

20 25 30

Leu Thr Glu Gin Leu Glu Thr Val Ala Gin Tyr Glu Gly His Leu Leu

35 40 45

Asp Ser Ala Asp Asn Leu Leu Val Asn His 50 55

(2) INFORMATION FOR SEQ ID NO:401:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 58 ammo acids

(B) TYPE: amino acid

(C) STRANDEDNESS: -single

(D) TOPOLOGY: linear^'

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:401:

Met He Tyr Gly Ala Ile Ile Aεp Ala Lyε Thr Ala Glu Asn Ala Ala

1 5 10 15

Gly Met Thr Ala Met Gin Thr Ala Thr Asp Asn Ala Lys Lyε Val Ile 20 25 30 Asn Asp Leu Thr He Gin Tyr Asn Arg Ala Gin Thr Gly Gly Tyr Tyr

35 40 45

Thr Arg Asn Tyr Arg Asn Arg Ser Ser Ala 50 55

(2) INFORMATION FOR SEQ ID NO:402:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:402:

Met Thr Asp Gly Tyr Glu His Tyr Lys Lys Ile Met Glu Asn Pro Pro

1 5 10 15

Lys Asn Leu Ile Phe Pro Gly Ile Val Ser Pro Glu Arg Met Arg Glu

20 25 30

Ile Val Cys Ser Asn Gly Ser Phe Leu Val Ala 35 40

(2) INFORMATION FOR SEQ ID NO:403:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:403:

Met Ser Lys Gin Lys Lys Phe Glu Glu Asn Leu Ala Glu Leu Glu Thr

1 5 10 15

Ile Val Gin Ser Leu Glu Asn Gly Glu lie Ala Leu Glu Asp Ala Ile

20 25 30

Thr Ala Phe Gin Lys Gly Met Val Leu Ser Lys Glu Leu Gin Ala Thr

35 40 45

Leu Asp Lys Ala Glu Lys Thr Leu Val Lys Val Met Gin Glu Asp Gly 50 55 60 Thr Glu Ser Asp Phe Glu 65 70

(2) INFORMATION FOR SEQ ID NO:404:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:404:

Met Phe Ala Ala Val Thr Ala Gly Tyr Gin Ala Ala Leu Met Val Pro

1 5 10 15

Thr Glu Ile Leu Ala Glu Gin His Phe Glu Ser Leu Gin Asn Leu Phe

20 25 30

Pro Asn Leu Lys Leu Ala Leu Leu Thr Gly Ser Leu Lys Ala Ala Glu

35 40 45

Lys Arg Glu Val Leu Glu Thr Ile Ala Lys Gly Glu Ala Asp Leu Ile

50 55 60

Ile Gly Thr His Ala Leu Ile Gin Asp Gly Val Glu Tyr Ala Arg Leu 65 70 75 80

Gly Leu Ile Ile Ile Asp Glu Gin His Arg Phe Gly Val Gly Gin Arg

85 90 95

Arg Ile Leu Arg Glu Lys Gly Asp Asn Pro Asp Val Leu Met Met Thr

100 105 110

Ala Thr Pro lie Pro Arg Thr Leu Ala Ile Thr Ala Phe Gly Asp Met

115 120 125

Asp Val Ser Ile Ile Asp Gin Met Pro Ala Gly Arg Lys Pro Tyr Cys

130 135 140

Asp Ala Leu Asp Gin Thr 145 150

(2) INFORMATION FOR SEQ ID NO:405:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 110 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:405:

Met Asn Arg Glu Ala Leu Arg Leu Tyr Leu Val Thr Asn Arg Tyr Gin

1 5 10 15

Asp Ser Val Glu Ser Phe Leu Ala Lys Val Glu Thr Ala Cyε Arg Ser

20 25 30

Gly Val Thr Ile Val Gin Leu Arg Glu Lys Asn Leu Thr Thr Asn Gin

35 40 45

Tyr Tyr Gin Leu Ala Lyε Gin Val Lys Glu Ile Thr Asp Ala Tyr Gin

50 55 60

Val Pro Leu Ile Ile Aεp Asp Arg Leu Asp Val Cys Leu Ala Val Asp 65 70 75 80

Ala Ala Gly Leu His Ile Gly Asp Asp Glu Leu Pro Val Ser Val Ala

85 90 95

Arg Gin Val Leu Gly Pro Glu Lys Ile Pro Arg Cys Hiε Arg 100 105 110

(2) INFORMATION FOR SEQ ID NO:406:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 98 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: εingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:406:

Met Gin Gly Ser Hiε Phe His Leu Pro Ile Tyr Arg Met Thr Ser Gin

1 5 10 15

Ala Leu Leu Asp Glu Thr Lys Lys Val Ala Ile Pro Val Leu Ala Thr

20 ^' 25 30

Thr Gin Ser Lys Asp Ser Val Asp Tyr Arg Glu Leu Pro Ser Ile Glu

35 40 45

Asn Phe Val Leu Val Met Gly Asn Glu Gly Gin Gly Ile Ser Pro Leu

50 55 60

Met Ala Glu Ser Ala Asp Gin Leu Val His Ile Ser Met Lys Gly Gin 65 70 75 80

Ala Glu Ser Leu Asn Val Ala Val Ala Ala Gly Ile Leu Ile Phe His

85 90 95

Leu Ser (2) INFORMATION FOR SEQ ID NO:407:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 137 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:407:

Met Thr Lys Thr Ala Phe Leu Phe Ala Gly Gin Gly Ala Gin Tyr Leu

1 5 10 15

Arg Met Gly Arg Asp Phe Tyr Asp Gin Tyr Pro Ile Val Lys Glu Thr

20 25 30

Ile Asp Arg Ala Ser Gin Val Leu Gly Tyr Asp Leu Arg Tyr Leu Ile

35 40 45

Asp Thr Glu Glu Asp Lys Leu Asn Gin Thr Arg Tyr Thr Gin Pro Ala

50 55 60

Ile Leu Ala Thr Ser Val Ala Ile Tyr Arg Leu Leu Gin Glu Lys Gly 65 70 75 80

Tyr His Pro Asp Met Val Ala Gly Leu Ser Leu Gly Glu Tyr Ser Ala

85 90 95

Leu Val Ala Ser Gly Ala Leu Asp Phe Glu Asp Ala Val Ala Leu Val

100 105 110

Ala Lys Arg Gly Ala Tyr Met Glu Glu Ala Ala Pro Ala Asp Ser Gly

115 120 125

Lys Met Val Ala Val Leu His Thr Pro 130 135

(2) INFORMATION FOR SEQ ID NO:408:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:408: Met Tyr Gin Phe Ser Gly Gin Thr Lys Val Xaa Glu Val Leu Ala Phe

1 5 10 15

Arg Asp Lys Pro Pro Tyr Gly Gly Ser Ser Ala Met Pro Leu Arg Cys

20 25 30

Leu

(2) INFORMATION FOR SEQ ID NO:409:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 52 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:409:

Met Thr Lys Glu Thr Gly Met Glu Gin Thr Phe Phe Ile lie Lys Pro

1 5 10 15

Asp Gly Val Lys Arg Gly Leu Val Gly Glu Val Leu Lys Arg lie Glu

20 25 30

Gin Arg Gly Phe Thr Ile Glu Lys Leu Glu Phe Arg Ser Gin Val Phe

35 40 45

Arg Arg Val Asp 50

(2) INFORMATION FOR SEQ ID NO:410:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:410:

Met Thr Ser Gly Pro Val Leu Val Gly Val Ile Ser Gly Pro Lys Val

1 5 10 15 Ile Glu Thr Trp Arg Thr Met Met Gly Ala Thr Arg Pro Glu Glu Ala

20 25 30

Leu Pro Gly Thr Ile Arg Gly Asp Phe Ala Lys Ala Ala Gly Glu Asn

35 40 45

Glu lie Ile Gin Asn Val Val His Gly Ser Asp Ser Glu Lys Asn Gin

50 55 60

Leu Ser Arg Glu Ile Ala Pro Leu Val Leu Arg Val Asp Trp Leu Asn 65 70 75 80

Gin Leu Asp Lys Ser Ser Phe Glu 85

(2) INFORMATION FOR SEQ ID NO:411:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:411:

Met Gly Leu Lys Asp Asn Ala Gly Leu Val Lys Glu Tyr Ala Leu Val

1 5 10 15

Asp Ala Val Glu Tyr Gin Asn Val Ile Val Ala Thr Thr Val Glu Glu

20 25 30

Met Leu Ser Lys Tyr Ala Asn Lys Asn Asp Leu Glu Ile Asp Asn Ala

35 40 45

Thr Thr Glu Ser Ile Lys Gly Val Val Ala Asp Leu Lys Ser Ala Val

50 55 60

Ile Lys Gly Asp Thr Val Tyr Phe Phe Lys Val Asp Gly Lys Ile Tyr 65 70 75 80

Lys Val Lys Ala Ser Val Ser Asp Asp Leu Pro Tyr Leu Glu Asn Gly

85 90 95

Lys Thr Phe Glu Gly Gin Val Xaa Lys Asp Asn Tyr Leu Lys Thr Phe

100 105 110

Lys Val Gin 115

(2) INFORMATION FOR SEQ ID NO:412:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 50 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:412:

Met Ile Ser Gly Ser Glu Ile Arg Asp Ile Val Thr Ser Asp Ile Pro

1 5 10 15

Leu Ala Asp Lys Thr Glu Thr Leu Val Arg Phe Ala Asn Asn Ala Gly

20 25 30

Gly Leu Asp Asn Ile Thr Val Ala Leu Val Ser Met Asn Glu Glu Asp

35 40 45

Glu Glu 50

(2) INFORMATION FOR SEQ ID NO: 413:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 76 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:413:

Met Pro Asp Asn Leu Ala Leu Arg Met Arg Pro Lys Thr Ile Asp Gin

1 5 10 15

Val Ile Gly Gin Glu Xaa Leu Val Gly Pro Gly Lyε Ile Ile Arg Arg

20 25 30

Met Val Glu Ala Aεn Arg Leu Ser Ser Met Ile Leu Tyr Gly Pro Pro

35 40 45

Gly Ile Gly Lys Thr Ser Ile Ala Ser Ala Ile Ala Gly Thr Thr Lys

50 55 60

Tyr Ala Phe Arg Thr Phe Asn Ala Thr Val Asp Ser 65 70 75

(2) INFORMATION FOR SEQ ID NO:414:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 amino acidε (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:414:

Met Pro Glu Glu Leu Ala Tyr Leu Val Gin His Leu Asp Asn Ala Gin

1 5 10 15

Glu Gin Val Val Leu Gly Asn Thr Tyr His Thr Gly Asn His Cys Phe

20 25 30

Ser

(2) INFORMATION FOR SEQ ID NO:415:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 415:

Met Val Phe Trp Glu Gly Leu Val Pro Thr Pro Asp Val Ile Asp Ala

1 5 10 15

Gly His Val Thr Gly Phe Leu Tyr Thr Val His Ser Ser Ser Thr Gly

20 25 30

Leu Ile Val Leu Gin Ile Lys Lys Asp Leu Leu Lys Leu 35 40 45

(2) INFORMATION FOR SEQ ID NO:416:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 143 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 416:

Met Thr Asp Arg Tyr Asp Ser Ser Leu Gly Ile Tyr Lys Val Pro Trp

1 5 10 15

Cys Val Ser Gin Gin Gin Thr Val Thr Glu Ile Met Asp Thr Tyr Cys

20 25 30

Asp Trp Gly Val Lys Tyr Pro Leu Val Tyr Leu Glu Asp Pro Phe Ser

35 40 45

Asp Glu Asp Leu Asp Ser Trp Arg Lys Phe Gin Leu Ile Lys Pro Leu

50 55 60

Lys Leu Gin Val Phe Gly Asp Asp Phe Tyr Ala Thr Asn Leu Glu Arg 65 70 75 80

Ile Ser Gin Phe Lys Asp Cys Ala Asp Gly Ile Val Ile Lys Pro Asn

85 90 95

Gin Val Gly Ser Val Ser Lys Thr Leu Glu Val Met Glu Tyr Ala Glu

100 105 110

Lys Ser Gly Ile Ser Met Ala Phe Ser Gin Arg Thr Ala Glu Thr Glu

115 120 125

Asn Asn Ile Ile Ser His Leu Ala Met Ser Val Ile Leu Leu Ile 130 135 140

(2) INFORMATION FOR SEQ ID NO:417:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 120 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:417:

Met Lys Lys Ile Ser Lys Gin Glu Leu Val Asn Thr Arg Phe Ser Arg

1 5 10 15

Leu Phe Ala His Phe Gly Gin Glu Lys Asp Gly Ser Phe Leu Ala Gin

20 25 30

Arg Tyr Gin Phe Tyr Leu Ala Gin Gin Gly Gin Thr Leu Ser Gly Ala

35 40 45

His Asp Leu Leu Asp Ser Leu Ile Glu Arg Asp Tyr Asn Leu Tyr Ala

50 55 60

Ala Thr Asn Gly Ile Thr Ala Ile Gin Thr Gly Arg Leu Ala Gin Ser 65 70 75 80 Gly Leu Ala Pro Tyr Phe Asn Gin Val Phe Ile Ser Glu Gin Leu Gin

85 90 95

Thr Gin Lys Pro Asp Ala Leu Phe Tyr Glu Lyε Ile Gly Gin Gin Ile

100 105 110

Ala Gly Phe Ser Lys Glu Lyε Thr 115 120

(2) INFORMATION FOR SEQ ID NO:418.

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 114 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:418-

Met His Arg Lys Thr Val Ile Asp Xaa Arg Thr Leu Gly Glu Arg Tyr

1 5 10 15

Thr Phe Thr Xaa Pro Ile Lys Glu Leu Lys Thr Arg Asn Val Ala Glu

20 25 30

Val Ala Asp Leu Leu Ala Xaa Val Glu Ser Tyr Gin Glu Gin Asp Tyr

35 40 45

Tyr Val Val Gly Tyr Val Ser Tyr Glu Ala Ala Pro Ala Phe Glu Glu

50 55 60

Lys Leu Ala Val His Lys Val Pro Leu Leu Gly Glu Tyr Leu Leu Tyr 65 70 75 80

Phe Thr Val His Aεp Arg Val Glu Thr Ser Pro Ile Pro Leu Thr Tyr

85 90 95

Glu Asp Ile Asp Leu Pro Ser Asn Trp Gin Gly Xaa Asn Val Cys Thr

100 105 110

Glu Leu

(2) INFORMATION FOR SEQ ID NO:419:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 ammo acidε

(B) TYPE: ammo acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:419:

Met Glu Arg Ile Glu Val Arg Ser Arg Ser Gly Ser Ala Hiε Leu Gly

1 5 10 15

His Val Phe Thr Asp Gly Pro Arg Glu Leu Gly Gly Leu Arg Tyr Cys

20 25 30

Ile Asn Ser Ala Ser Leu Arg Phe Val Ala Lyε Asp Glu Met Glu Lys

35 40 45

Ala Gly Tyr Gly Tyr Leu Leu Pro Tyr Leu Asn Lyε 50 55 60

(2) INFORMATION FOR SEQ ID NO:420:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 82 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:420:

Met Glu Trp Ile Arg Leu Ile Gly Ile Ala Ile Ile Val Val Gly Phe

1 5 10 15

Ile Leu Lys Phe Asp Thr Ile Ala Thr Val Val Leu Ala Gly Leu Val

20 25 30

Thr Ala Leu Val Ser Gly Val Ser Leu Val Glu Phe Leu Glu Ile Leu

35 40 45

Gly Lyε Glu Phe Ser Asn Gin Arg Val Leu Thr Ile Phe Met Val Thr

50 55 60

Leu Pro Leu Val Gly Leu Ser Glu Thr Phe Gly Leu Asn Asn Asp Gin 65 70 75 80

Ser Ile

(2) INFORMATION FOR SEQ ID NO:421

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 125 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:421:

Met Leu Leu Ile Phe Ala Val Ile Gly Val Leu Val Ala Leu Ile Ala

1 5 10 15

Gin Phe Tyr Ser Ala Lys Ala Ala Val Gly Phe Ala Lys Glu Leu Thr

20 25 30

Asn Asp Leu Tyr Arg His Ile Leu Ser Leu Pro Lys Asp Ser Arg Asp

35 40 45

Arg Leu Thr Thr Ser Ser Leu Val Thr Arg Leu Thr Ser Asp Thr Tyr

50 55 60

Gin Ile Gin Thr Gly Ile Asn Gin Phe Leu Arg Leu Phe Leu Arg Ala 65 70 75 80

Pro Ile Ile Val Phe Gly Ala Ile Phe Met Ala Tyr Arg Ile Ser Ala

85 90 95

Glu Leu Thr Phe Trp Phe Leu Val Met Val Ala Ile Leu Thr Ile Val

100 105 110

Ile Val Arg Val Ile Ser Ile Gly Gin Ser Ser Leu Gin 115 120 125

(2) INFORMATION FOR SEQ ID NO:422:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 38 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:422:

Met Pro Ile Glu Gin Val Gin Lys Leu Leu Gly His Ser Lys Ile Asp

1 5 10 15

Thr Thr Leu Ala Tyr Ala Met Val Asn Gin Asn Asn Val Lys His Ser

20 25 30

His Gin Lys Phe Ile Ser 35

(2) INFORMATION FOR SEQ ID NO:423: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 87 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:423:

Met Lys Pro Cys Trp Lys Lys Cys Phe Pro Glu Glu Val Ser Ser Glu

1 5 10 15

Gly Glu Val Thr Leu Ile Glu Ile Pro Val Ser Asp Lys Ile Ala Gly

20 25 30

Lys Gin Val His Glu Leu Asn Leu Pro His Asn Val Leu Ile Thr Thr

35 40 45

Gin Val His Asn Gly Lys Ser Gin Thr Val Asn Gly Ser Thr Arg Met

50 55 60

Tyr Leu Gly Asp Met Ile His Leu Val Ile Pro Lys Ser Glu Ile Gly 65 70 75 80

Lys Val Lys Asp Leu Leu Leu 85

(2) INFORMATION FOR SEQ ID NO:424:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:424:

Met Asn Glu Gly Val Glu Asn Phe Arg Ala Lys Leu Ala Ser Leu Gly

1 5 10 15

Ala Lys Asn Ile Gly Ile Tyr Val Gly Val Tyr Phe Met Glu Glu His

20 25 30

Ser Ile Asp Thr Gly Lys Phe Thr Ser Val Trp Ile Pro Ser Tyr Gly

35 40 45

Ser Asp Ser Gly Phe Leu Glu Ser Ser Pro Lys Thr Asp Leu Asp Tyr 50 55 60 Asp Ile His Gin Tyr Thr Ser Lys Gly Lys Leu Pro Ala Leu Thr Thr 65 70 75 80

Ile

(2) INFORMATION FOR SEQ ID NO:425:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 107 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:425:

Met Val Ser Lys Tyr Leu Leu Leu Ala Val Ile Phe Ser Gly Leu Val

1 5 10 15

Thr Trp Ile Leu Arg Met Ile Ser Phe Ile Leu Val Lys Tyr Lys Gly

20 25 30

Leu Pro Ala Ile Val Glu Arg Phe Leu Lys Phe Leu Pro Val Ser Ile

35 40 45

Ile Phe Ala Leu Ile Leu Ser Ser Val Val Thr Gly Lys Val Gly Ser

50 55 60

Leu Pro Gin Ile Lys Trp Leu Asp Phe Leu Ala Val Phe Pro Thr Ala 65 70 75 80

Trp Val Ala Phe Arg Tyr Arg Asn Leu Leu Gly Thr Val Leu Phe Gly

85 90 95

Val Val Leu Ile Ala Ile Leu Arg Leu Val Ser 100 105

(2) INFORMATION FOR SEQ ID NO:426:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 141 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:426: Met Glu Asp Xaa Glu Thr Gin Arg Val Val Met Gin Tyr Arg Ala Pro

1 5 10 15

Glu Asn Asn Arg Trp Ser Gly Tyr Ala Phe Pro Gly Gly His Val Glu

20 25 30

Asn Asp Glu Ala Phe Ala Glu Ser Val Ile Arg Glu Ile Tyr Glu Glu

35 40 45

Thr Gly Leu Thr Ile Gin Asn Pro Gin Leu Val Gly Ile Lys Asn Trp

50 55 60

Pro Leu Asp Thr Gly Gly Arg Tyr Ile Val Ile Cys Tyr Lys Ala Thr 65 70 75 80

Glu Phe Ser Gly Thr Leu Gin Ser Ser Glu Glu Gly Glu Val Ser Trp

85 90 95

Val Gin Lys Asp Gin Ile Pro Asn Leu Asn Leu Ala Tyr Asp Met Leu

100 105 110

Pro Leu Met Glu Met Met Glu Ala Pro Asp Lys Ser Glu Phe Phe Tyr

115 120 125

Pro Arg Arg Thr Glu Asp Asp Trp Glu Lys Lys Ile Phe 130 135 140

(2) INFORMATION FOR SEQ ID NO:427:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 67 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:427:

Met Thr Ile Glu Leu Leu Thr Pro Phe Thr Lys Val Glu Leu Glu Pro

1 5 10 15

Glu Ile Lys Glu Lys Lys Arg Lys Gin Val Gly Ile Leu Gly Gly Asn

20 ^' 25 30

Phe Asn Pro Val His Asn Ala His Leu Ile Val Ala Asp Gin Val Arg

35 40 45

Gin Gin Leu Gly Leu Asp Gin Val Leu Leu Met Pro Glu Tyr Gin Pro

50 55 60

Pro His Val 65

(2) INFORMATION FOR SEQ ID NO:428: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 96 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:428:

Met Lys Lys Leu Val Phe Val Cys Leu Gly Asn Ile Cys Arg Ser Pro

1 5 10 15

Met Ala Glu Phe Val Met Lys Ser Met Thr Aεp Aεn Tyr Glu Ile Gin

20 25 30

Ser Arg Ala Thr Ser Ser Trp Glu His Gly Asn Pro Ile Hiε Lyε Gly

35 40 45

Thr Gin Gly Ile Phe Gin Glu Tyr Glu Ile Pro Tyr Asp Lys Asn Lys

50 55 60

Thr Ser Leu Gin Ile Ser Lys Glu Asp Phe Glu Ala Phe Asp Tyr Ile

65 70 75 80

Ile Gly Met Asp Ala Ser Asn Val Pro Thr Tyr Val Arg Cys Val Gin 85 90 95

(2) INFORMATION FOR SEQ ID NO:429:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 53 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:429:

Met Val Lys Tyr Gly Val Val Gly Ala Gly Tyr Phe Gly Ala Glu Leu

1 5 10 15

Ala Arg Tyr Met Gin Lys Asn Asp Gly Ala Xaa Ile Thr Leu Leu Tyr

20 25 30

Asp Pro Asp Asn Ala Glu Ala Ile Ala Glu Glu Leu Gly Ala Lys Val

35 40 45

Ser Lys Phe Leu Arg 50 (2) INFORMATION FOR SEQ ID NO:430:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 74 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:430:

Met Leu Trp Lys Tyr Tyr Asn Ser Ser Phe Leu Lys Ala Val Pro His

1 5 10 15

Leu Thr Thr Glu Tyr Lys Arg Leu Ala Gin Ala Hiε Gly Leu Asn Leu

20 25 30

Lys Gin Ala Lys Pro Ile Thr Met Gly Met Trp Ile Gly Gly Asp Arg

35 40 45

Glu Gly Asn Pro Phe Val Thr Ala Lys Asn Leu Lys Gin Ser Ala Leu

50 55 60

Thr Gin Cys Glu Val Xaa Leu Asn Leu Leu 65 70

(2) INFORMATION FOR SEQ ID NO:431:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:431:

Met Asn Thr Leu Tyr Leu Asn Gin His Ser Ser Tyr Lys Asn Asp Glu

1 5 10 15

Asp Ser His Ser Phe Pro Ile Gin Met Glu Leu Val Ser Asp Glu Met

20 25 30

Ile Pro Arg Asn 35

(2) INFORMATION FOR SEQ ID NO:432: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 94 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:432:

Met Ala Arg Lys Glu Thr Met Ala Glu Arg Lys Tyr Cys Lys Met Lys

1 5 10 15

Lys Asp Ile His Pro Glu Tyr Arg Pro Val Val Phe Met Asp Thr Thr

20 25 30

Thr Gly Tyr Gin Phe Leu Ser Gly Ser Thr Lys Arg Ser Asn Glu Thr

35 40 45

Val Glu Phe Glu Gly Glu Thr Tyr Pro Leu Ile Arg Val Glu Ile Ser

50 55 60

Ser Asp Ser His Pro Phe Tyr Thr Gly Arg Gin Lys Phe Thr Gin Ala 65 70 75 80

Asp Gly Arg Val Asp Arg Phe Asn Lys Lys Tyr Gly Leu Lys 85 90

(2) INFORMATION FOR SEQ ID NO:433:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 90 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-433:

Met Glu Thr Ala Leu Ile Ser Val Ile Val Pro Val Tyr Asn Val Ala

1 10 15

Gin Tyr Leu Glu Lys Ser Ile Ala Ser Ile Gin Lys Gin Thr Tyr Gin

20 25 30

Asn Leu Glu Ile Ile Leu Val Asp Asp Gly Ala Thr Asp Glu Ser Gly

35 40 45

Arg Leu Cys Asp Ser Ile Ala Glu Gin Asp Asp Arg Val Ser Val Leu 50 55 60 His Lyε Lys Asn Glu Gly Leu Ser Gin Ala Arg Asn Aεp Gly Met Lyε 65 70 75 80

Pro Gly Ser Arg Gly Leu Ser Aεp Phe Tyr 85 90

(2) INFORMATION FOR SEQ ID NO:434:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: εingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 434:

Met Tyr Phe Leu Ile Asn Phe Val Tyr Pro Val Asp Met Val Ile Asn

1 5 10 15

Leu Pro Phe Leu Ile Asn Thr Gly Leu Ile Val Leu Leu Ser Ala Ile

20 25 30

Ser Tyr Ile Ser Leu Leu Val Phe Thr Lys Asp Ser Ile Phe Tyr Glu

35 40 45

Phe Leu Asn His Val Leu Ala Leu Lys Asn Lys Phe Lys Lys Ser 50 55 60

(2) INFORMATION FOR SEQ ID NO:435:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 435:

Met Arg Val Ile Ala Trp Leu Glu Pro Ser Arg Lyε Ile Leu Gin Pro

1 5 10 15

Gly Ala Asn Asp Val Trp Val Val Lys Arg Lys Gly Lys Arg Asp Leu

20 25 30

Leu Leu Pro Tyr Ile Pro Pro Val Val Leu Asn Val Aεp Ile Pro Asn 35 40 45 Lys Arg Val Asp Val Glu Ile Leu Glu Gly Leu Asp Asp Glu Asp 50 55 60

(2) INFORMATION FOR SEQ ID NO:436:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:436:

Met Asp Asp Asp Phe Lys Arg Tyr Asn Ala Pro Ile Leu Thr Trp Tyr

1 5 10 15

Glu Thr Ala Arg Tyr Ala Phe Glu Arg Gly Met Val Trp Gin Asn Leu

20 25 30

Gly Gly Val Glu Asn Ser Leu Asn Gly Gly Leu Tyr His Phe Lys Glu

35 40 45

Lys Phe Asn Pro Thr Ile Glu Glu Tyr Leu Gly Glu Phe Thr Met Pro

50 55 60

Thr His Pro Leu Tyr Pro Leu Leu Arg Leu Ala Leu Asp Phe Arg Lys 65 70 75 80

Thi- Leu Arg Lys Lys His Arg Lys 85

(2) INFORMATION FOR SEQ ID NO:437:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

( i) SEQUENCE DESCRIPTION: SEQ ID NO:437:

Met Glu Asp Phe Phe Ala Trp Cys Arg Arg Gin Ser Val Leu Ser Gly

1 5 10 15

Ser Lys Leu Gly Arg Ala Ile Glu Tyr Ser Leu Lys Tyr Glu Glu Thr 20 25 30 Phe Lys Thr Ile Leu Lys Asp Gly Hiε Leu Val Leu Ser Asn Asn Leu

35 40 45

Ala Glu Arg Ala Ile Lys Ser Leu Val Met Gly Arg Ser Lys Arg Val

50 55 60

Gin Trp Thr Leu Leu Ala 65 70

(2) INFORMATION FOR SEQ ID NO:438:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:438:

Met Thr Lys Gin Gly Ser Trp Lys Leu Ile Leu Glu Asp Glu Ser Ala

1 5 10 15

Gly Arg Glu Leu Phe Pro Ile Leu Thr Gin Gly Xaa Tyr Ile Ala Thr

20 25 30

Phe Asp Gin Gin Ala Pro Xaa Ile Asp Glu Ile Phe Lys Leu 35 40 45

(2) INFORMATION FOR SEQ ID NO: 439:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 53 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: εingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:439:

Met Thr Thr Asn Xaa Asp Asn Asp Thr Ser Glu Arg Ser Asp Cys Tyr

1 5 10 15

Arg Lys Arg Thr Ala Gly Glu Thr Pro Met Asn Asp Leu Thr Ser His

20 25 30

Thr His Gly Gly Asn Tyr Thr Ile Ala Arg Tyr Gin Glu Glu Lys Phe 35 40 45 Trp Asn Lys Gin Leu 50

(2) INFORMATION FOR SEQ ID NO:440:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 ammo acids

(B) TYPE: amino acid

(C) STRANDEDNESS: Single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO:440:

Met Ala Gin His Ala Ala Val Glu Ala Leu Thr Ala Gly Lys Asn Asp

1 5 10 15

Ala Glu Pro Met Lys Lys Glu Tyr Ile Gin Arg Arg Asp Tyr Ile Ile

20 25 30

Glu Lys Met Thr Ala Leu Gly Phe Glu lie Ile Lys Pro Asp Gly Ala

35 40 45

Phe Tyr Ile Phe Ala Lys Ile Pro Ala Gly Tyr Asn Gin Asp Ser Phe

50 55 60

Ala Phe Leu Lys Asp Phe Ala Gin Lys Lys Ala Val Ala Phe Ile Pro 65 70 75 80

Gly Ala Ala Phe Gly Arg Tyr Gly Glu Gly Tyr Val Arg Leu Ser Tyr

85 90 95

Ala Ala Ser Met Glu Thr Ile Lys Glu Ala Met Lys Arg Leu Glu Glu

100 105 110

Tyr Met Arg Glu Ala 115

(2) INFORMATION FOR SEQ ID NO:441:

(l) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 96 amino acids

(B) TYPE: ammo acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(Xl) SEQUENCE DESCRIPTION: SEQ ID NO:441: Met Asn Ile Thr Asn Leu Phe Ser Ile Lys Thr Gly Cys Asp Glu Thr

1 5 10 15

Asp Arg Gin Leu Gin Lys Leu Phe Phe Gin Leu Asp Leu Gin Leu Gly

20 25 30

Glu Leu Thr Asp Gin Leu Arg Lys Leu Asp Ser Asn Phe Val Pro Arg

35 40 45

Ser Gin Phe Val Asp Thr Leu Aεp Leu Aεn Aεp Val Glu Tyr Lyε Glu

50 55 60

Ile Leu Asn Tyr Phe Ile Phe His Arg Asn Asp Ser Glu Glu Ser Leu 65 70 75 80

Val Glu Trp Leu Tyr Asp Trp Ile Ser Thr Asn Arg Tyr Glu Leu Pro 85 90 95

(2) INFORMATION FOR SEQ ID NO:442:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:442:

Met Leu Gin Trp Ile Asp Arg Thr Phe Gin Asp Tyr Leu Glu Leu Glu

1 5 10 15

His Leu Val Leu Thr Thr Trp Ser Gly Asn Leu Gly Met Met Lyε Leu

20 25 30

Ala Glu Lys Leu Xaa Met Lys Lys Xaa Ala His Ile Xaa Lys Val Arg

35 40 45

Tyr Tyr Gin Gly Lys Tyr Phe Asp Ser Ile Lys Tyr Gly Ile Leu Arg

50 55 60

Xaa Asp Trp Glu Lys Ile Asn Asp Gly Tyr Tyr Gin Ile Tyr Xaa Asn 65 70 75 80

Ser

(2) INFORMATION FOR SEQ ID NO:443:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 171 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:443:

Met Ile Val Glu Glu Val Arg Asp Arg Tyr Val Gly Lys Val Asp Ala

1 5 10 15

Val Phe His Asn Gly Asp Ser Glu Leu Arg Pro Asp Ser Pro Leu Trp

20 25 30

Glu Gly Ile Arg Val Val Lys Gly Asn Met Asp Phe Tyr Ala Gly Tyr

35 40 45

Pro Glu Arg Leu Val Thr Glu Leu Gly Ser Thr Lys Ile Ile Gin Thr

50 55 60

His Gly His Leu Phe Asp Ile Asn Phe Asn Phe Gin Lys Leu Asp Tyr 65 70 75 80

Trp Ala Gin Glu Glu Glu Ala Ala Ile Cys Leu Tyr Gly His Leu His

85 90 95

Val Pro Ser Ala Trp Leu Glu Gly Lys Ile Leu Phe Leu Asn Pro Gly

100 105 110

Ser Ile Ser Gin Pro Arg Gly Thr Ile Arg Glu Cys Leu Tyr Ala Arg

115 120 125

Val Glu Ile Asp Asp Ser Tyr Phe Lys Val Asp Phe Leu Thr Arg Asp

130 135 140

His Glu Val Tyr Pro Gly Cys Pro Arg Ser Leu Ala Asp Asp Ala Lys 145 150 155 160

Glu Leu Arg Leu Ser Val Gly Ala Glu Asn Phe 165 170

(2) INFORMATION FOR SEQ ID NO:444:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:444:

Met Asn Leu His Gin Pro Leu His Val Leu Pro Gly Val Gly Pro Lys

1 5 10 15 Ser Ala Glu Lys Tyr Ala Lys Leu Gly Ile Glu Asn Leu Gin Asp Leu

20 25 30

Leu Leu Tyr Phe Pro Phe Arg Tyr Glu Asp Phe Lys Thr Lys Gin Val

35 40 45

Leu Glu Leu Glu Asp Gly Glu Lys Ala Val Leu Ser Gly Gin Val Val

50 55 60

Thr Pro Ala Ser Val Gin Tyr Tyr Gly Phe Gin Ala Ala Asn Pro Pro 65 70 75 80

Ala Phe Leu Val Leu Gin Ala Arg Glu Glu Gly Ser Phe Phe Phe Gly

85 90 95

Gly

(2) INFORMATION FOR SEQ ID NO:445:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:445:

Met Gin Leu Leu Ser Glu Asn Met Leu Lys Thr Ile Gin Ser Leu Ser

1 5 10 15

Val Trp Gin Ile Tyr Leu Leu Gly Phe Glu Arg Ile Leu Ala Leu Gly

20 25 30

Phe Gin Leu Leu Leu Thr Val Trp Val Tyr Gin Ala Val Arg Gin Lyε

35 40 45

Lyε Trp Ile Tyr Leu Leu Ala Ala Tyr Gly Leu Hiε Ala Phe Phe Asp

50 55 60

Leu Ala Pro Ser Leu Phe Gin Val Gly Trp Leu Thr Asn Pro Val Leu 65 70 75 80

Val Glu Val Ile Leu Ala Leu Glu Leu Val Leu Val Ala Tyr Gly Thr

85 90 95

Lys Glu Ile Phe Cys Lys Lys Ser 100

(2) INFORMATION FOR SEQ ID NO:446:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 122 amino acidε (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:446:

Met Thr Lys Ser Met Thr Pro Asp Arg Glu Val Ile Thr Phe Ile Pro

1 5 10 15

Glu Lys Phe Ile Val Asp Gly Phe Gin Gly Ile Arg Asp Pro Arg Gly

20 25 30

Met Met Gly Val Arg Leu Glu Met Arg Gly Leu Leu Tyr Thr Gly Pro

35 40 45

Arg Thr Ile Leu His Asn Leu Arg Lys Thr Val Glu Arg Ala Gly Val

50 55 60

Gin Val Glu Asn Val lie Ile Ser Pro Leu Ala Met Val Gin Ser Val 65 70 75 80

Leu Asn Glu Gly Glu Arg Glu Phe Gly Ala Thr Val Ile Asp Met Gly

85 90 95

Ala Gly Gin Thr Thr Val Ala Thr Ile Arg Asn Gin Glu Leu Gin Phe

100 105 110

Thr His lie Leu Gin Glu Val Glu Ile Met 115 120

(2) INFORMATION FOR SEQ ID NO:447:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 123 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:447:

Met Leu Asn Ser Ile Val Thr Ile Ile Cys Ile Ala Leu Ile Ala Phe

1 5 10 15

Ile Leu Phe Trp Phe Phe Lys Lys Pro Glu Lys Ser Gly Gin Lys Ala

20 25 30

Gin Gin Lyε Asn Gly Tyr Gin Glu Ile Arg Val Glu Val Met Gly Gly 35 40 45 Tyr Thr Pro Glu Leu Ile Val Leu Lys Lys Ser Val Pro Ala Arg Ile

50 55 60

Val Phe Asp Arg Lys Asp Pro Ser Pro Cys Leu Asp Gin Ile Val Phe 65 70 75 80

Pro Asp Phe Gly Val His Ala Asn Leu Pro Met Gly Glu Glu Tyr Val

85 90 95

Val Glu Ile Thr Pro Glu Gin Ala Gly Glu Phe Gly Phe Ala Cys Gly

100 105 110

Met Asn Met Met His Gly Lys Met Ile Val Glu 115 120

(2) INFORMATION FOR SEQ ID NO:448:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 116 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:448:

Met Lys Ile Val Ser Gly Ile Tyr Gly Gly Arg Pro Leu Lys Thr Leu

1 5 10 15

Glu Gly Lys Thr Thr Arg Pro Thr Ser Asp Lys Val Arg Gly Ala Ile

20 25 30

Phe Asn Met Ile Gly Pro Tyr Phe Glu Val Gly Xaa Val Leu Aεp Leu

35 40 45

Tyr Ala Gly Ser Gly Gly Leu Ser Ile Glu Ala Val Ser Arg Gly Met

50 55 60

Ser Ser Ala Val Leu Val Glu Arg Aεp Arg Lyε Ala Gin Thr Ile Val 65 70 75 80

Ala Glu Asn Ile Gin Met Thr Lys Glu Val Gly Lys Phe Gin Leu Leu

85 ^' 90 95

Gin Asn Gly Cys Arg Lys Gly Ile Gly Thr Gly Xaa Leu Gly Asn Leu

100 105 110

Thr Ser Phe Ser 115

(2) INFORMATION FOR SEQ ID NO:449:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 52 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:449:

Met Xaa Thr Asn Phe Thr Asp Gin Val Asp Thr Met Ile Tyr Val Asp

1 5 10 15

Lys Glu Glu Lys Glu Thr Ile Lys Ala Ala Leu Val Glu Phe Phe Asn

20 25 30

Gly Lys Val Thr Leu Thr Asp Gin Gly Leu Arg Glu Val Glu Val Pro

35 40 45

Val Asn Leu Val 50

(2) INFORMATION FOR SEQ ID NO:450:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 75 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:450:

Met Ile Gly Val Ala Leu Glu Glu Ser Pro Thr Leu Lys lie His His

1 5 10 15

Leu Thr His Asp Ile Thr Pro Tyr Asn Ile Phe Glu Gly Ser Tyr Arg

20 25 30

Leu Phe Gin Thr Val Asp Tyr Trp Pro Glu Gly Thr Thr Phe Val Ser

35 40 45

Val Val Asp Pro Gly Val Gly Ser Lys Arg Lys Ser Val Val Ala Lys

50 55 60

Thr Ala Gin Lys Ser Ile His Cys His Ala Arg 65 70 75

(2) INFORMATION FOR SEQ ID NO:451:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 130 amino acids (B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:451:

Met Glu Leu Arg Arg Pro Arg Leu Ala Asp Lys Lys Ala Val Leu Asp

1 5 10 15

Met Met Thr Glu Phe Glu Lys Ser Gin Ser Ala His Asp Gly Gly Phe

20 25 30

Trp Asp Thr Glu Asn Phe Val Tyr Glu Glu Trp Leu Glu Ser Asn Gin

35 40 45

Glu Gin Glu Met Gly Ile Asn Leu Pro Glu Gly Trp Val Pro Ala Ile

50 55 60

Gin Leu Val Ala Phe Ser Glu Lys Gly Gin Ala Val Gly Phe Leu Asn 65 70 75 80

Leu Arg Leu Arg Leu Ser Asn Phe Leu Leu Glu Glu Gly Gly His Ile

85 90 95

Gly Tyr Ser Ile Arg Pro Ser Glu Arg Gly Lys Gly Tyr Ala Lys Glu

100 105 110

Leu Ser Val Arg Ala Cys Lys Leu Leu Arg Lys Arg Thr Ser Arg Lys

115 120 125

Leu Trp 130

(2) INFORMATION FOR SEQ ID NO:452:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:452:

Met Thr Phe Ile Arg Gly Pro Ile Ile Ser Thr Val Gly Glu Gly Val

1 5 10 15

Xaa Ile Leu Ala Thr Val Asn Xaa Gin Phe Val Xaa Xaa Gin Xaa Xaa

20 25 30 Asn Met Leu Val Ser Pro Phe His Pro Glu Leu Thr Asp Xaa Xaa Arg

35 40 45

Leu Xaa Gin Tyr Phe Ile Ser Met Cys Lys Glu Lys Ser Xaa Asp 50 55 60

(2) INFORMATION FOR SEQ ID NO:453:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:453:

Met Lys Gly Asp Val Ile Thr Glu His Gin Phe Tyr Glu Gin Val Lys

1 5 10 15

Asn Asn Pro Ser Ala Gin Xaa Val Leu Leu Asn Met Thr Ile Gin Lys

20 25 30

Val Phe Glu Lys Thr Ile Trp Leu Arg Ala 35 40

(2) INFORMATION FOR SEQ ID NO:454:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:454:

Met Asp Lys Ala Leu Ala Asp Leu Lys Thr Ser Gly His Leu Pro Ile

1 5 10 15

Pro Arg His Leu Arg Asp Gly His Tyr Xaa Gly Ser Lys Glu Leu Gly

20 25 30

Asn Ala Gin Asp Tyr Leu Tyr Pro His Asn Tyr Pro Xaa Asn Trp Val

35 40 45

Lys Gin Asp Tyr Leu Pro Gin Lys Ile Arg Asn His His Tyr Phe Gin 50 55 60 Ala Glu Tyr Thr Gly Lys Tyr Glu Arg Ala Leu Ala Gin Arg Lys Glu 65 70 75 80

Ala Ile Asp His Leu Arg Lys Ile 85

(2) INFORMATION FOR SEQ ID NO:455:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 90 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:455:

Met Val Val Phe Thr Gly Ser Thr Val Glu Glu Ala Ile Gin Lys Gly

1 5 10 15

Leu Lys Glu Leu Asp Ile Pro Arg Met Lys Ala His Ile Lys Val Ile

20 25 30

Ser Arg Glu Lys Lys Gly Phe Leu Gly Leu Phe Gly Lys Lys Pro Ala

35 40 45

Gin Val Asp Ile Glu Ala Ile Ser Glu Thr Thr Val Val Lys Ala Asn

50 55 60

Gin Gin Val Val Lyε Gly Val Pro Lyε Lyε Ile Aεn Asp Leu Asn Glu

65 70 75 80

Pro Val Lys Thr Val Ser Val Arg Asn Arg 85 90

(2) INFORMATION FOR SEQ ID NO:456:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:456:

Met Thr Lys Arg Cys Ser Trp Val Lys Met Thr Asn Pro Leu Tyr Ile

1 5 10 15 Ala Tyr His Asp Glu Glu Trp Gly Gin Pro Leu His Asp Asp Gin Ala

20 25 30

Leu Phe Glu Leu Leu Cys Met Glu Thr Tyr Gin Ala Gly Leu Ser Trp

35 40 45

Glu Thr Val Leu Asn Lys Arg Gin Ala Phe Arg Glu Ala Phe Pro 50 55 60

(2) INFORMATION FOR SEQ ID NO:457:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:457:

Met Phe Val Gly Gin Glu Trp Thr Asn Gin Thr Phe Val Asp Leu Leu

1 5 10 15

Gly Asn His Gin Gly Gin Val Thr Ile Asp Glu Glu Gly Tyr Gly Gin

20 25 30

Phe Pro Val Ser Ala Arg Ser Val Ser Val Trp Ala Val Asn Thr Ile 35 40 45

(2) INFORMATION FOR SEQ ID NO:458:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 51 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 458:

Met Ala Gin Val Asp Ile Ile His Gly Ile Gly Thr Gly Val lie Arg

1 5 10 15

Glu Gly Val Thr Lys Tyr Leu Gin Arg Asn Lys His Val Lys Ser Phe

20 25 30

Gly Tyr Ala Pro Gin Asn Ala Gly Gly Ser Gly Ala Thr Ile Val Thr 35 40 45 Phe Lys Gly 50

(2) INFORMATION FOR SEQ ID NO:459:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 45 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:459:

Met Asn Leu Leu Glu Glu Ala Thr Lys Gly Lys Val Ile Phe Glu Gly

1 5 10 15

Val Asp Ile Thr Asp Lys Lys Asn Asp Leu Phe Pro Met Arg Glu Lys

20 25 30

Met Gly Met Val Phe Gin Gin Phe Asn Xaa Phe Leu Ile 35 40 45

(2) INFORMATION FOR SEQ ID NO:460:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 129 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:460:

Met Gin Ile Asp Leu Ala Asn Leu Leu Pro Asp Leu Pro Gly Asn Leu

1 5 10 15

Ser Gly Ile Asn Pro Asn Arg Tyr Val Phe Tyr Gin Asp Val Leu Cys

20 25 30

Pro Ile Leu Asp Arg His Met Thr Pro Glu Gin Asp Lys Pro His Phe

35 40 45

Ala Gin Ala Ala Gly Thr Ile Ala Asp Ile Lys Glu Lys Ala Gly Asn

50 55 60

Tyr Ala Tyr Leu Phe Glu Thr Gin Ala Gin Leu Asn Ala Ile Leu Ser 65 70 75 80 Ser Lys Val Asp Val Gly Arg Arg Ile Arg His Ala Tyr Gin Ala Asp

85 90 95

Asp Lys Glu Ser Leu Gin Gin Ile Ala Arg Gin Glu Leu Pro Glu Leu

100 105 110

Arg Ser Gin Ile Glu Asp Phe His Ala Leu Phe Ser His Hiε Trp Leu

115 120 125

Lys

(2) INFORMATION FOR SEQ ID NO:461:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 59 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 461:

Met Arg Gin Gly Ile Asp Ser Leu Ala Tyr Val Val Lys Thr His Phe

1 5 10 15

Glu Leu Asp Pro Phe Ser Gly Gin Ala Phe Leu Phe Cys Gly Gly Arg

20 25 30

Lys Asp Arg Phe Lys Ala Leu Tyr Trp Asp Gly Gin Gly Phe Trp Leu

35 40 45

Leu Tyr Lys Arg Phe Glu Asn Gly Lys Leu Thr 50 55

(2) INFORMATION FOR SEQ ID NO:462:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 108 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:462:

Met Asn Ala Phe Leu Glu Glu Leu Ser Gin Ala Tyr Pro Asp Aεp Tyr 1 5 10 15 Phe Leu Leu Val Met Asp Asn Ala Ile Trp His Lys Ser Ser Val Leu

20 25 30

Lys Ile Pro Thr Asn Ile Gly Phe Ala Phe Ile Pro Pro Tyr Thr Pro

35 40 45

Glu Met Asn Pro Ile Glu Gin Val Trp Lys Glu Ile Arg Lys Arg Gly

50 55 60

Phe Lys Asn Lys Ala Phe Arg Ile Leu Glu Asp Val Met Asn Gin Leu 65 70 75 80

Gin Asp Val Ile Gin Gly Leu Glu Lys Glu Val Ile Lys Ser Ile Val

85 90 95

Asn Arg Arg Trp Thr Arg Met Leu Phe Glu Ser Arg 100 105

(2) INFORMATION FOR SEQ ID NO:463:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 88 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:463:

Met Thr Val Glu Glu Glu Lys Val Phe Leu Ala Arg His Leu Lys Ala

1 5 10 15

Thr Glu Ala Gly Glu Phe Val Thr Ile Asp Ala Leu Phe Gin Ala Tyr

20 25 30

Lys Lys Glu Leu Gly Arg Ser Tyr Thr Arg Asp Ala Phe Tyr Gin Leu

35 40 45

Leu Lys Arg His Gly Trp Arg Asn Ile Met Pro Arg Pro Glu His Pro

50 55 60

Lys Lys Ala Asp Ala Gin Thr Ile Val Ala Ser Lys Asn Lys Ile Ser 65 70 75 80

Ile Gin Glu Asp Lys Lys Ala Ile 85

(2) INFORMATION FOR SEQ ID NO:464:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 124 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:464:

Met Leu Ser Leu Val Val Leu lie Thr Gin Tyr Ala Thr His Gly Glu

1 5 10 15

Leu Phe Glu Asn Tyr Ile Ser Lys Glu Asn Asp Asn Val Ile Lys Glu

20 25 30

Tyr Gin Asn Thr Thr Gly Phe Ser Thr Pro Tyr Thr Leu Asp Gly Ser

35 40 45

Val Leu lie Val His Pro Asp Leu Thr Lys Gly Met Asn Ile Glu Gly

50 55 60

Tyr Ser Asp Leu Leu Lys Pro Glu Leu Lys Gly Lys Ile Ala Thr Ala 65 70 75 80

Asp Pro Ala Asn Ser Ser Ser Ala Phe Ala Gin Leu Thr Asn Met Leu

85 90 95

Gin Ala Gin Gly Gly Tyr Lys Asp Asp Leu Ala Trp Ser Val Leu Ser

100 105 110

Thr Ile Phe Ser Thr Leu Ile Asp Gly Ile Val Lys 115 120

(2) INFORMATION FOR SEQ ID NO:465:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 148 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:465:

Met Leu Ala Arg Lys Asp Arg Phe Tyr Tyr Ile Asp Lys Ala Thr Gly

1 5 10 15

Lys Ala Leu Gly Ile Phe Leu Ser Cys Val Leu Thr Ser Asn Gly Val

20 25 30

Ile Glu Val Gly Ala Val Thr Phe Ser Pro Lys Leu Arg Gly Thr Arg

35 40 45 Ile Gly Thr Glu Ala Gin Tyr Leu Leu Ala Arg Tyr Val Phe Glu Glu

50 55 60

Leu Asn Tyr Arg Arg Tyr Glu Trp Lys Cys Asp Ala Leu Asn Leu Pro 65 70 75 80

Ser Arg Arg Ala Ala Glu Arg Leu Gly Phe Ile Tyr Glu Gly Thr Phe

85 90 95

Arg Gin Ala Val Val Tyr Lys Gly Arg Thr Arg Asp Met Asp Trp Leu

100 105 110

Ser Met Ile Asp Lys Asp Trp Pro Lys Val Lys Asp Arg Leu Glu Thr

115 120 125

Trp Leu Arg Pro Glu Asn Phe Asp Lys Asn Gly Gin Gin Tyr Lys Ser

130 135 140

Leu Arg Glu Leu 145

(2) INFORMATION FOR SEQ ID NO:466:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:466:

Met Met Thr Ser Asp Phe Phe Glu Val Trp Phe Gin Lys Phe Leu Leu

1 5 10 15

Pro Thr Leu Thr Thr Pro Ser Val Ile Ile Val Lys 20 25

(2) INFORMATION FOR SEQ ID NO:467:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 112 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:467: Met Val Ser Thr Lys Thr Gin Ile Ala Gly Phe Glu Phe Asp Asn Cys

1 5 10 15

Leu Met Asn Ala Ala Gly Val Ala Cys Met Thr Ile Glu Glu Leu Glu

20 25 30

Glu Val Lys Asn Ser Ala Ala Gly Thr Phe Val Thr Lys Thr Ala Thr

35 40 45

Leu Asp Phe Arg Gin Gly Asn Pro Glu Pro Arg Tyr Gin Asp Val Pro

50 55 60

Leu Gly Ser Ile Asn Ser Met Gly Leu Pro Asn Asn Gly Leu Asp Tyr 65 70 75 80

Tyr Leu Asp Tyr Leu Leu Asp Leu Gin Glu Lys Glu Ser Asn Arg Thr

85 90 95

Phe Phe Leu Ser Leu Val Gly Met Ser Pro Glu Lys Pro Ile Leu Phe 100 105 110

(2) INFORMATION FOR SEQ ID NO:468:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 35 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:468:

Met Thr Tyr Leu Met Phe Ser Gly Leu Asp Glu Asn Phe Tyr His Phe

1 5 10 15

Pro Trp Glu Val Phe Ala Gly Phe Gly Ile Ile Phe Leu Ala Cys Pro

20 25 30

Glu Lys Val 35

(2) INFORMATION FOR SEQ ID NO:469:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 amino acidε

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:469:

Met Phe Thr Gly Trp Phe Ala Gin Thr Phe Leu His Gin Phe Ile Arg

1 5 10 15

Gly Ala Trp Gly Leu Gly Phe Met Ile Phe Ile Ala Phe Pro Met Gly

20 25 30

Lys Glu Leu Leu Glu Gly Glu Tyr His Glu His Asp

35 40

(2) INFORMATION FOR SEQ ID NO:470:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 145 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 70:

Met Gin Glu Lys Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Thr

1 5 10 15

His Thr Val Ile Glu Leu Ile Gin Ala Gly His Gin Val Val Val Val

20 25 30

Asp Asn Leu Val Asn Ser Asn Xaa Lys Ser Leu Glu Val Val Glu Arg

35 40 45

Ile Thr Gly Val Glu Ile Pro Phe Tyr Glu Ala Asp Ile Xaa Asp Thr

50 55 60

Asp Thr Leu Arg Asp Ile Phe Lys Gin Glu Glu Leu Thr Gly Val Ile 65 70 75 80

His Phe Ala Gly Leu Lys Ala Val Gly Glu Ser Thr Arg Ile Pro Leu

85 90 95

Ala Tyr Tyr Asp Asn Asn Ile Ala Gly Thr Val Ser Leu Leu Lyε Ala

100 105 110

Met Glu Glu Asn Asn Cys Lys Asn Ile Ile Phe Ser Ser Xaa Ala Thr

115 120 125

Val Tyr Gly Asp Pro Tyr Thr Val Pro Ile Leu Glu Val Ser His Phe

130 135 140

Gin 145

(2) INFORMATION FOR SEQ ID NO:471: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 200 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:471:

Met Val Lys Glu Lys Val Thr Leu Thr Pro Leu Ala Ser Gly Tyr Gin

1 5 10 15

Ile Gly Glu Glu Glu Phe Glu Gin Val Ile Leu Ala Xaa Gly Ala Trp

20 25 30

Leu Gly Asp Met Leu Glu Pro Leu Gly Tyr Glu Val Asp Val Arg Pro

35 40 45

Gin Lys Gly Gin Leu Arg Asp Tyr Gin Leu Val Gin Asp Met Glu Ala

50 55 60

Tyr Pro Val Val Met Pro Glu Gly Glu Trp Asp Leu Ile Pro Phe Ala 65 70 75 80

Gly Gly Lys Leu Ser Leu Gly Ala Thr His Glu Asn Asp Met Gly Phe

85 90 95

Asp Leu Thr Val Asp Glu Thr Leu Leu Gin Gin Met Glu Glu Ala Thr

100 105 110

Leu Thr His Tyr Leu Ile Leu Ala Glu Ala Thr Ser Lys Ser Glu Arg

115 120 125

Val Gly Ile Arg Ala Tyr Thr Ser Asp Phe Ser Pro Phe Phe Gly Gin

130 135 140

Val Pro Asp Leu Thr Gly Val Tyr Ala Ala Ser Gly Leu Gly Ser Ser 145 150 155 160

Gly Leu Thr Thr Gly Pro Ile Ile Gly Tyr His Leu Ala Gin Leu Ile

165 170 175

Gin Asp Lys Glu Leu Thr Leu Asp Pro Glu Asn Tyr Pro Ile Glu Asn

180 185 190

Tyr Val Lys Arg Val Lys Ser Glu 195 200

(2) INFORMATION FOR SEQ ID NO:472:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:472:

Met Glu His Ile Ile Tyr Gin Phe Glu Glu Asp Leu Ala Ile Leu Thr

1 5 10 15

Leu Asn Arg Pro Glu Val Ala Asn Gly Phe His Ile Pro Met Cys Glu

20 25 30

Glu Ile Leu Glu Ala Leu Thr Leu Ala Glu Glu Asn Pro Ala Val His

35 40 45

Phe Ile Leu Ile Asn Ala Asn Gly Lys Val Phe Ser Val Gly Gly Asp

50 55 60

Leu Val Glu Met Lys Arg Ala Val Asp Glu Asp Asp Ile Pro Ser Leu 65 70 75 80

Thr Lys Ile Ala Glu Leu Val Asn Thr Ile Ser Tyr Lys Ile Lys Gin

85 90 95

Ile Ala Lys Pro Val Phe Asn Gly Ser 100 105

(2) INFORMATION FOR SEQ ID NO:473:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 81 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:473:

Met Gin Pro Glu Val Ile Trp Leu Gin Lys Ile Ala Lys Pro Ser Gin

1 5 10 15

Met Lys Val Leu Asn Thr Thr Asp Arg Val Gin Ala Ile Lys Asp Asp

20 25 30

Val Asp Ile Ile Gin Asn Ser Leu Gin Ile Ile Asn Gin Gin Lys Glu

35 40 45

Leu Ile Lys Glu Tyr Gin Glu Asp Leu Thr Tyr Lys Phe Lys Val Leu

50 55 60

Glu Lys Asp Ile Gin Thr Arg Thr Ser Cys Asp Lys Arg Asn Ala Gly 65 70 75 80

Asn ( 2 ) INFORMATION FOR SEQ ID NO : 74 :

( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 135 amino acids

(B) TYPE : amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:474:

Met Gly Ser Asn Ser Leu Thr Leu Leu Leu Lys Ile Gin Ala Thr Ile

1 5 10 15

Pro Arg Asn Ile Tyr Asp Aεn Leu Gin Ala Gly Ser Lys Val Thr Leu

20 25 30

Asp Arg Ala Tyr Gly His Met Ile Ile Glu Glu Gly Arg Glu Asn Gin

35 40 45

Val Trp Ile Ala Gly Gly Ile Gly Ile Thr Pro Phe Ile Ser Tyr Ile

50 55 60

Arg Glu His Pro Ile Leu Asp Lys Gin Val His Phe Tyr Tyr Ser Phe 65 70 75 80

Arg Gly Asp Glu Asn Ala Val Tyr Leu Asp Leu Leu Arg Asn Tyr Ala

85 90 95

Gin Lys Asn Pro Asn Phe Glu Leu His Leu Ile Asp Ser Thr Lys Asp

100 105 110

Gly Tyr Leu Asn Phe Glu Gin Lys Lys Cys Pro Asn Met Gin Pro Ser

115 120 125

Ile Cys Val Val Leu Phe Leu 130 135

(2) INFORMATION FOR SEQ ID NO:475:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:475: Met Phe Phe Val Leu Ala Tyr Ala Lys Ala Val Ala Gly Arg Asn Ile

1 5 10 15

Lys Leu His Pro Ile Gin Arg Gin Gly Ala Gly Tyr His Ser Val Asn

20 25 30

Lys Asp Val Asp Phe Ala Ser Ala Thr Ala Leu Arg Gin His Gin Lys

35 40 45

Asp Gin Asp Phe Leu Glu Arg Phe Met Pro Ser Val Ala Leu Phe Glu

50 55 60

Gin Ala Ser Lys Val Ile Trp Glu Asp Tyr Phe Pro Leu Leu Arg Tyr 65 70 75 80

Gin Ile Leu Ser Asn Pro Asp Leu Thr Thr Ile Tyr Gin Val Asn Gin

85 90 95

Glu Met Ala Val Arg Ile Lys Glu Ala Ile Lys Thr Ala Gin Ser Val

100 105 110

Glu Glu Leu Val Glu Leu Val Thr Thr Lys Arg Tyr Thr Lys Ala Arg

115 120 125

Val Arg Arg Leu Leu Thr Tyr Ile Leu Met Gin Ala Arg Glu Ser Asp

130 135 140

Leu Pro Glu Ala Ile His Val Leu Gly Phe Thr Glu Lys Gly Arg Gin 145 150 155 160

His Leu Lys Ser Leu Lys Gly Gin Val Asn Leu Val Ser Arg Ile Gly

165 170 175

Lys Glu Pro Trp Asp Ala Met Thr Gin Lys Val Asp Gin Ile Tyr Gin

180 185 190

Leu Gly Lys Pro Ser Ile Ala Glu Gin Asn Phe Gly Arg Val Pro Ile

195 200 205

Arg Ile Glu Thr Asn 210

(2) INFORMATION FOR SEQ ID NO:476:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 76 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:476:

Met Leu Gly Ser Met Phe Val Gly Leu Leu Val Gly Phe Leu Ala Gly 1 5 10 15 Ala Met Thr Asn Arg Gly Glu Arg Met Gly Cys Phe Gly Lys Met Phe

20 25 30

Leu Gly Trp Ile Gly Ala Phe Leu Gly His Leu Leu Phe Gly Thr Trp

35 40 45

Gly Pro Val Leu Ser Gly Thr Ala Ile Ile Pro Ala Val Leu Gly Ala

50 55 60

Met Ile Val Leu Ala Ile Phe Trp Arg Arg Gly Ser 65 70 75

(2) INFORMATION FOR SEQ ID NO:477:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:477:

Met Arg Ser Ser Pro Ser Arg Glu Ile Gin Pro Arg Ser Trp Gly Ile

1 5 10 15

Thr Thr Val Tyr Val Thr His Asp Gin Glu Gly Ala Met Ala Ile Ser

20 25 30

Asp Gin Ile Ala Cys Tyr Glu Arg Trp Gly Asp Pro Thr Asn Arg Pro

35 40 45

Thr Lys Arg Thr Val Ser 50

Claims

WHAT IS CLAIMED IS:

1. An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of: (a) a polynucleotide having al least a 70% identity to a polynucleotide encoding a polypeptide comprising an amino acid sequence of selected from the group consisting of SEQ ID NO:224 through 477,

(b) a polynucleotide which is complementary to the polynucleotide of (a);

(c) a polynucleotide having at least a 70% identity to a polynucleotide encoding the same mature polypeptide expressed by the a gene comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO: 1 through 223 contained in the DNA of the deposited clone; and

(d) a polynucleotide comprising at least 15 sequential bases of the polynucleotide of (a), (b) or(c).

2. The polynucleotide of Claim 1 wherein the polynucleotide is DNA.

3. The polynucleotide of Claim 1 wherein the polynucleotide is RNA.

4. The polynucleotide of Claim 2 comprising the nucleic acid sequence set forth in SEQ ID NO: 1.

5. The polynucleotide of Claim 2 comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 through 223.

6. The polynucleotide of Claim 2 which encodes a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:224 through 477.

7. A vector comprising the polynucleotide of Claim 1.

8. A host cell comprising the vector of Claim 7.

9. A process for producing a polypeptide comprising: expressing from the host cell of Claim 8 a polypeptide encoded by said DNA.

10. A process for producing a noval polypeptide or fragment comprising culturing a host of claim 8 under conditions sufficient for the production of said polypeptide or fragment.

11. A polypeptide comprising an amino acid sequence which is at least 70% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:224 through 477.

12. A polypeptide comprising an amino acid selected from the group consisting of

SEQ ID NO:224 through 477.

13. An antibody against the polypeptide of claim 11.

14. An antagonist which inhibits the activity or expression of the polypeptide of claim 11.

15. A method for the treatment of an individual in need of a Streptococcal polypeptide comprising: administering to the individual a therapeutically effective amount of the polypeptide of claim 11.

16. A method for the treatment of an individual having need to inhibit a bacterial polypeptide comprising: administering to the individual a therapeutically effective amount of the antagonist of Claim 14.

17. A process for diagnosing a disease related to expression or activity of the polypeptide of claim 11 in an individual comprising:

(a) determining a nucleic acid sequence encoding said polypeptide, and/or

(b) analyzing for the presence or amount of said polypeptide in a sample derived from the individual.

18. A method for identifying compounds which interact with and inhibit or activate an activity ofthe polypeptide of claim 11 comprising: contacting a composition comprising the polypeptide with the compound to be screened under conditions to permit interaction between the compound and the polypeptide to assess the interaction of a compound, such interaction being associated with a second component capable of providing a detectable signal in response to the interaction ofthe polypeptide with the compound; and determining whether the compound interacts with and activates or inhibits an activity ofthe polypetide by detecting the presence or absence of a signal generated from the interaction of the compound with the polypeptide.

19. A method for inducing an immunological response in a mammal which comprises inoculating the mammal with Streptococcal polypeptide of claim 11, or a fragment or variant thereof, adequate to produce antibody and/or T cell immune response to protect said animal from disease.

20. A method of inducing immunological response in a mammal which comprises delivering a nucleic acid vector to direct expression of Streptococcal polypeptide of claim 11 , or fragment or a variant thereof, for expressing said Streptococcal polypeptide, or a fragment or a variant thereof in vivo in order to induce an immunological response to produce antibody and/ or T cell immune response to protect said animal from disease.

21. An isolated Streptococcal polypeptide having one of the amino acid sequences of SEQ ID NO:224 through SEQ ID NO:234.

22. An isolated nucleic acid encoding one of the amino acid sequences of Claim 21 and nucleic acid sequences capable of hybridizing therewith under stringent conditions.

23. Recombinant vectors comprising the nucleic acid sequences of Claim 22 and host cells transformed or transfected therewith.

24. A method of identifying an antimicrobial compound comprising contacting candidate compounds with a polypeptide of Claim 21 and selecting those compounds capable of inhibiting the bioactivity of said polypeptide.

25. Antimicrobial compounds identified by the method of Claim 24.