WO1997044662A1 - Integral fluid and waste container for blood analyzer - Google Patents
Integral fluid and waste container for blood analyzer Download PDFInfo
- Publication number
- WO1997044662A1 WO1997044662A1 PCT/US1997/008259 US9708259W WO9744662A1 WO 1997044662 A1 WO1997044662 A1 WO 1997044662A1 US 9708259 W US9708259 W US 9708259W WO 9744662 A1 WO9744662 A1 WO 9744662A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluid
- bag
- flexible
- calibrant
- cartridge
- Prior art date
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 266
- 239000002699 waste material Substances 0.000 title claims abstract description 92
- 239000008280 blood Substances 0.000 title claims abstract description 68
- 210000004369 blood Anatomy 0.000 title claims abstract description 68
- 238000007789 sealing Methods 0.000 claims abstract description 38
- 239000011800 void material Substances 0.000 claims abstract description 9
- 238000009792 diffusion process Methods 0.000 claims abstract 3
- 238000004891 communication Methods 0.000 claims description 89
- 239000011241 protective layer Substances 0.000 claims description 32
- 239000000463 material Substances 0.000 claims description 26
- 229910052782 aluminium Inorganic materials 0.000 claims description 22
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 22
- 238000004159 blood analysis Methods 0.000 claims description 18
- 239000011248 coating agent Substances 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 239000006260 foam Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 229920000098 polyolefin Polymers 0.000 claims description 4
- 230000005484 gravity Effects 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims 4
- 230000001070 adhesive effect Effects 0.000 claims 4
- 150000004645 aluminates Chemical class 0.000 claims 2
- 239000007789 gas Substances 0.000 abstract description 16
- 239000011888 foil Substances 0.000 description 11
- 230000001681 protective effect Effects 0.000 description 8
- 230000007246 mechanism Effects 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 238000009534 blood test Methods 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- DMFGNRRURHSENX-UHFFFAOYSA-N beryllium copper Chemical compound [Be].[Cu] DMFGNRRURHSENX-UHFFFAOYSA-N 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000135 prohibitive effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
- B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N2001/2893—Preparing calibration standards
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87917—Flow path with serial valves and/or closures
- Y10T137/87925—Separable flow path section, valve or closure in each
- Y10T137/87941—Each valve and/or closure operated by coupling motion
- Y10T137/87949—Linear motion of flow path sections operates both
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87917—Flow path with serial valves and/or closures
- Y10T137/87925—Separable flow path section, valve or closure in each
- Y10T137/87965—Valve- or closure-operated by coupling motion
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Definitions
- both the calibration and waste fluids are preferably provided in a single cartridge or container.
- the cartridge can be secured within a main housing of the blood analysis machine via rails on the cartridge that mate to grooves on the main housing, in order to guide the cartridge into the blood analyzer housing.
- the cartridge has a latch that securely locks the cartridge in place within the housing.
- the mating connection between fluid fittings on the blood analyzer and the cartridge is substantially gas-tight.
- the fluid communication port of a calibration bag also includes a self-sealing valve, which is located substantially within the fluid communication path, that prevents the flow of calibration fluid through the port body, unless the flow fitting (e.g., the Luer fitting) is engaging the self-sealing valve.
- the fluid communication port includes a flange that is coupled to the port body for securing the fluid communication port to the locating element on the cartridge.
- the flange and port body are an integral unit from the polyolefin family of plastics.
- the self- sealing valve is preferably a poppet valve that has a valve stem and a stem backstop that fit within the port body.
- FIGURE 5E is a front view of the calibrant fluid port, showing a flange on the port.
- the cartridge 104 has a plurality of fitting holes 106 (as shown, three) that permit the passage of fluids between the housing 102 and the calibrant and waste containers (not shown) within the cartridge 104.
- the housing has a plurality of fluid fittings 108, corresponding in number to the fitting holes 106, that mate to fluid ports (not shown) of the cartridge 104 when it is inserted fully into the housing 102.
- the fluid fittings 108 are preferably a male-type fitting that fit within and through the fitting holes 106.
- FIGURE 3 shows two calibrant bags 302, 304 and one waste bag 306 in the side tray 120. It should be understood, however, that such an arrangement is merely exemplary and that the cartridge 104 could contain fewer or more than two calibrant bags and more than one waste bag. There is some advantage, however, to having at least two calibrant bags 302, 304.
- the first calibrant bag 302 may have approximately twice the volume of the second bag 304, so that the first bag can be used for periodically calibrating the blood analyzer 100 as well as for flushing the analyzer 100 after each blood sample is tested. The other, smaller calibrant bag 304 can then be used strictly for calibration.
- FIGURE 3 also shows the fluid communication port 310 for the calibration bags 302, 304 as well as the fluid communication port 312 for the waste bag 306.
- the fluid communication ports 310, 312 are coupled to the calibrant bags 302, 304 and the waste bag 306, respectively, which in turn can be coupled to the fluid fittings 108 of the main housing 102. These ports 310, 312 allow fluid communication between the main housing 102 and the cartridge 104.
- the waste bag is preferably coupled to fluid communication port 312 by a length of plastic tubing 308, while the calibrant bags 302, 304 are preferably directly coupled to ports 310. Directly coupling the calibrant bags 302, 304 to the fluid communication ports 310 permits the connection between the calibrant bags 302, 304 and main housing 102 to be substantially gas tight.
- FIGURES 5A-5F illustrate an exemplary embodiment of the calibrant fluid communication port 310.
- the fluid communication port shown in FIGURES 5A-5F and described below will be referred to as a calibrant fluid communication port.
- the fluid communication port shown in FIGURES 5A-5F is not limited, however, to the calibrant bags 302, 304, but can also be used for a waste bag 306.
- the waste port 312 may differ from the calibrant port 310, because, preferably, the waste port 312 is coupled to the waste bag 306 by tubing 308, while the calibrant bags 302, 304 are preferably directly coupled to the calibrant ports 310 to provide substantially gas-tight seals.
- FIGURE 5A is a side-view of the exemplary calibrant fluid communication port 310 of the present invention.
- the fluid communication port 310 has a port body 402, a flange 404, a fitting end 502, a bag end 504, a fluid communication path 422, and a self-sealing valve assembly 506.
- the self-sealing valve assembly 506 is located within the fluid communication path 422, which is coaxial with the port body 402.
- the flange 404 substantially surrounds the port body 402, the two elements preferably being an integral assembly formed from polypropylene.
- polypropylene is the preferred material, other suitable materials exist.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97926530A EP0923732A1 (en) | 1996-05-20 | 1997-05-20 | Integral fluid and waste container for blood analyzer |
AU31274/97A AU3127497A (en) | 1996-05-20 | 1997-05-20 | Integral fluid and waste container for blood analyzer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/650,340 | 1996-05-20 | ||
US08/650,340 US5885533A (en) | 1996-05-20 | 1996-05-20 | Integral fluid and waste container for blood analyzer |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997044662A1 true WO1997044662A1 (en) | 1997-11-27 |
Family
ID=24608493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/008259 WO1997044662A1 (en) | 1996-05-20 | 1997-05-20 | Integral fluid and waste container for blood analyzer |
Country Status (4)
Country | Link |
---|---|
US (2) | US5885533A (en) |
EP (1) | EP0923732A1 (en) |
AU (1) | AU3127497A (en) |
WO (1) | WO1997044662A1 (en) |
Cited By (1)
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WO2020190633A1 (en) * | 2019-03-21 | 2020-09-24 | Siemens Healthcare Diagnostics Inc. | Fitment devices, reagent cartridges, and methods thereof |
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-
1997
- 1997-03-11 US US08/815,425 patent/US5882602A/en not_active Expired - Fee Related
- 1997-05-20 AU AU31274/97A patent/AU3127497A/en not_active Abandoned
- 1997-05-20 EP EP97926530A patent/EP0923732A1/en not_active Withdrawn
- 1997-05-20 WO PCT/US1997/008259 patent/WO1997044662A1/en not_active Application Discontinuation
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2020190633A1 (en) * | 2019-03-21 | 2020-09-24 | Siemens Healthcare Diagnostics Inc. | Fitment devices, reagent cartridges, and methods thereof |
Also Published As
Publication number | Publication date |
---|---|
US5885533A (en) | 1999-03-23 |
AU3127497A (en) | 1997-12-09 |
US5882602A (en) | 1999-03-16 |
EP0923732A1 (en) | 1999-06-23 |
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