WO1998013502A3 - Method to identify compounds for disrupting protein/protein interactions - Google Patents
Method to identify compounds for disrupting protein/protein interactions Download PDFInfo
- Publication number
- WO1998013502A3 WO1998013502A3 PCT/US1997/017276 US9717276W WO9813502A3 WO 1998013502 A3 WO1998013502 A3 WO 1998013502A3 US 9717276 W US9717276 W US 9717276W WO 9813502 A3 WO9813502 A3 WO 9813502A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- identify compounds
- disrupting
- interactions
- protein interactions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97944479A EP0915976A2 (en) | 1996-09-27 | 1997-09-26 | Method to identify compounds for disrupting protein/protein interactions |
AU45965/97A AU4596597A (en) | 1996-09-27 | 1997-09-26 | Method to identify compounds for disrupting protein/protein interactions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72173096A | 1996-09-27 | 1996-09-27 | |
US08/721,730 | 1996-09-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998013502A2 WO1998013502A2 (en) | 1998-04-02 |
WO1998013502A3 true WO1998013502A3 (en) | 1998-07-16 |
Family
ID=24899077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/017276 WO1998013502A2 (en) | 1996-09-27 | 1997-09-26 | Method to identify compounds for disrupting protein/protein interactions |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0915976A2 (en) |
AU (1) | AU4596597A (en) |
CA (1) | CA2236867A1 (en) |
WO (1) | WO1998013502A2 (en) |
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US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
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US9273308B2 (en) | 2006-05-11 | 2016-03-01 | Raindance Technologies, Inc. | Selection of compartmentalized screening method |
US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
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US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9440232B2 (en) | 2007-02-06 | 2016-09-13 | Raindance Technologies, Inc. | Manipulation of fluids and reactions in microfluidic systems |
US9448172B2 (en) | 2003-03-31 | 2016-09-20 | Medical Research Council | Selection by compartmentalised screening |
US9498759B2 (en) | 2004-10-12 | 2016-11-22 | President And Fellows Of Harvard College | Compartmentalized screening by microfluidic control |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
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US20050089896A1 (en) | 2003-02-18 | 2005-04-28 | Roy Frans V. | Method to control tumor progression and invasiveness |
AU2003210309A1 (en) | 2002-02-20 | 2003-09-09 | Universiteit Gent | Method of modulating e-cadherin mediated cell adhesion |
AU2004254552B2 (en) | 2003-01-29 | 2008-04-24 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
WO1995020652A1 (en) * | 1994-01-28 | 1995-08-03 | Medigene Gmbh | Method of determining the activity of a regulatory factor, and use of the method |
WO1995032284A1 (en) * | 1994-05-24 | 1995-11-30 | Ciba-Geigy Ag | Factor interacting with nuclear proteins |
WO1996001313A1 (en) * | 1994-07-01 | 1996-01-18 | Hermann Bujard | Tetracycline-regulated transcriptional modulators |
WO1996003499A1 (en) * | 1994-07-22 | 1996-02-08 | President And Fellows Of Harvard College | Receptor-ligand assay |
WO1996003501A1 (en) * | 1994-07-22 | 1996-02-08 | Ciba-Geigy Ag | Dual hybrid system |
-
1997
- 1997-09-26 CA CA 2236867 patent/CA2236867A1/en not_active Abandoned
- 1997-09-26 AU AU45965/97A patent/AU4596597A/en not_active Abandoned
- 1997-09-26 EP EP97944479A patent/EP0915976A2/en not_active Withdrawn
- 1997-09-26 WO PCT/US1997/017276 patent/WO1998013502A2/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
WO1995020652A1 (en) * | 1994-01-28 | 1995-08-03 | Medigene Gmbh | Method of determining the activity of a regulatory factor, and use of the method |
WO1995032284A1 (en) * | 1994-05-24 | 1995-11-30 | Ciba-Geigy Ag | Factor interacting with nuclear proteins |
WO1996001313A1 (en) * | 1994-07-01 | 1996-01-18 | Hermann Bujard | Tetracycline-regulated transcriptional modulators |
WO1996003499A1 (en) * | 1994-07-22 | 1996-02-08 | President And Fellows Of Harvard College | Receptor-ligand assay |
WO1996003501A1 (en) * | 1994-07-22 | 1996-02-08 | Ciba-Geigy Ag | Dual hybrid system |
Non-Patent Citations (3)
Title |
---|
J.C. CHRIVIA ET AL.: "Phosphorylated CREB binds specifically to the nuclear protein CBP", NATURE, vol. 365, 28 October 1993 (1993-10-28), MACMILLAN JOURNALS LTD., LONDON,UK, pages 855 - 859, XP002052727 * |
P. SUN AND R. MAURER: "An inactivating point mutation demonstrates that interaction of cAMP response element binding protein (CREB) with the CREB binding protein is not sufficient for transcriptional activation", J. BIOL. CHEM., vol. 270, no. 13, 31 March 1995 (1995-03-31), AM. SOC. BIOCHEM. MOL.BIOL.,INC.,BALTIMORE,US, pages 7041 - 7044, XP002052726 * |
SHIH H-M ET AL: "A positive genetic selection for disrupting protein-protein interactions: Identification of CREB mutations that prevent association with the coactivator CBP.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93 (24). 1996. 13896-13901. ISSN: 0027-8424, 16 November 1996 (1996-11-16), XP002052728 * |
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US9273308B2 (en) | 2006-05-11 | 2016-03-01 | Raindance Technologies, Inc. | Selection of compartmentalized screening method |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
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US9228229B2 (en) | 2010-02-12 | 2016-01-05 | Raindance Technologies, Inc. | Digital analyte analysis |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
Also Published As
Publication number | Publication date |
---|---|
CA2236867A1 (en) | 1998-04-02 |
EP0915976A2 (en) | 1999-05-19 |
AU4596597A (en) | 1998-04-17 |
WO1998013502A2 (en) | 1998-04-02 |
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