WO1998027962A3 - Injectable depot gel composition and method of preparing the composition - Google Patents

Injectable depot gel composition and method of preparing the composition Download PDF

Info

Publication number
WO1998027962A3
WO1998027962A3 PCT/US1997/023341 US9723341W WO9827962A3 WO 1998027962 A3 WO1998027962 A3 WO 1998027962A3 US 9723341 W US9723341 W US 9723341W WO 9827962 A3 WO9827962 A3 WO 9827962A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
injectable depot
polymer
gel
gel composition
Prior art date
Application number
PCT/US1997/023341
Other languages
French (fr)
Other versions
WO1998027962A2 (en
Inventor
Kevin J Brodbeck
Theodore T Shen
Original Assignee
Alza Corp
Kevin J Brodbeck
Theodore T Shen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21870398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998027962(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP52891698A priority Critical patent/JP2002512597A/en
Priority to DK97952507T priority patent/DK0949905T3/en
Priority to AT97952507T priority patent/ATE203157T1/en
Priority to EP97952507A priority patent/EP0949905B1/en
Priority to AU56097/98A priority patent/AU5609798A/en
Application filed by Alza Corp, Kevin J Brodbeck, Theodore T Shen filed Critical Alza Corp
Priority to CA002275587A priority patent/CA2275587C/en
Priority to DE69705746T priority patent/DE69705746T2/en
Publication of WO1998027962A2 publication Critical patent/WO1998027962A2/en
Publication of WO1998027962A3 publication Critical patent/WO1998027962A3/en
Priority to HK99105227A priority patent/HK1020009A1/en
Priority to GR20010401458T priority patent/GR3036599T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Abstract

An injectable depot gel composition containing a polymer, a solvent that can dissolve the polymer and thereby form a viscous gel, a beneficial agent; and an emulsifying agent in the form of a dispersed droplet phase in the viscous gel. The injectable depot gel composition can be prepared by mixing the polymer and the solvent so that the solvent dissolves the polymer and forms a viscous gel. The beneficial agent is dissolved or dispersed in the viscous gel and the emulsifying agent is mixed with the beneficial agent containing viscous gel. The emulsifying agent forms a dispersed droplet phase in the viscous gel to provide the injectable depot gel composition. The injectable depot gel composition can deliver a beneficial agent to a human or animal with a desired release profile.
PCT/US1997/023341 1996-12-20 1997-12-18 Injectable depot gel composition and method of preparing the composition WO1998027962A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE69705746T DE69705746T2 (en) 1996-12-20 1997-12-18 INJECTABLE DEPOT GEL PREPARATION AND PRODUCTION METHOD
DK97952507T DK0949905T3 (en) 1996-12-20 1997-12-18 Injectable depot preparation and method of preparation
AT97952507T ATE203157T1 (en) 1996-12-20 1997-12-18 INJECTABLE DEPOSIT GEL PREPARATION AND PRODUCTION METHOD
EP97952507A EP0949905B1 (en) 1996-12-20 1997-12-18 Injectable depot gel composition and method of preparing the composition
AU56097/98A AU5609798A (en) 1996-12-20 1997-12-18 Injectable depot gel composition and method of preparing the composition
JP52891698A JP2002512597A (en) 1996-12-20 1997-12-18 Injectable reservoir gel composition and method of making the composition
CA002275587A CA2275587C (en) 1996-12-20 1997-12-18 Injectable depot gel composition and method of preparing the composition
HK99105227A HK1020009A1 (en) 1996-12-20 1999-11-12 Injectable depot gel composition and method of preparing the composition
GR20010401458T GR3036599T3 (en) 1996-12-20 2001-09-12 Injectable depot gel composition and method of preparing the composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3343996P 1996-12-20 1996-12-20
US60/033,439 1996-12-20

Publications (2)

Publication Number Publication Date
WO1998027962A2 WO1998027962A2 (en) 1998-07-02
WO1998027962A3 true WO1998027962A3 (en) 1998-10-01

Family

ID=21870398

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1997/023341 WO1998027962A2 (en) 1996-12-20 1997-12-18 Injectable depot gel composition and method of preparing the composition
PCT/US1997/023659 WO1998027963A2 (en) 1996-12-20 1997-12-18 Gel composition and methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US1997/023659 WO1998027963A2 (en) 1996-12-20 1997-12-18 Gel composition and methods

Country Status (17)

Country Link
US (6) US6130200A (en)
EP (2) EP0959873B1 (en)
JP (4) JP4642946B2 (en)
KR (1) KR100616793B1 (en)
CN (1) CN1146402C (en)
AT (2) ATE318580T1 (en)
AU (2) AU5609798A (en)
CA (3) CA2275587C (en)
DE (2) DE69705746T2 (en)
DK (2) DK0959873T3 (en)
ES (2) ES2158611T3 (en)
GR (1) GR3036599T3 (en)
HK (2) HK1020009A1 (en)
IL (1) IL130532A0 (en)
NZ (1) NZ335851A (en)
PT (2) PT959873E (en)
WO (2) WO1998027962A2 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846072B2 (en) 2004-09-17 2014-09-30 Durect Corporation Controlled delivery system
US8945614B2 (en) 2002-12-13 2015-02-03 Durect Corporation Oral drug delivery system
US8956644B2 (en) 2006-11-03 2015-02-17 Durect Corporation Transdermal delivery systems
US8992961B2 (en) 1999-02-08 2015-03-31 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US9095553B2 (en) 2005-02-03 2015-08-04 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US9592204B2 (en) 2007-12-06 2017-03-14 Durect Corporation Oral pharmaceutical dosage forms

Families Citing this family (317)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US7833543B2 (en) 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
DE19545257A1 (en) 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
DK0959873T3 (en) * 1996-12-20 2006-07-03 Alza Corp Gel composition and methods
US6977074B2 (en) 1997-07-10 2005-12-20 Mannkind Corporation Method of inducing a CTL response
US6994851B1 (en) 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US6193991B1 (en) 1997-10-29 2001-02-27 Atul J. Shukla Biodegradable delivery systems of biologically active substances
ES2359973T3 (en) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. LIQUID POLYMER COMPOSITIONS FOR THE CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES.
US7128927B1 (en) * 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
US6565874B1 (en) * 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
ES2379471T5 (en) 1999-02-08 2015-05-26 Intarcia Therapeutics, Inc Non-aqueous single phase biocompatible viscous vehicles and procedures for their preparation
IT1308187B1 (en) * 1999-02-16 2001-12-07 Formenti Farmaceutici Spa TOPICAL PHARMACEUTICAL COMPOSITIONS BASED ON NONSTEROID ANTI-INFLAMMATORY.
US7018365B2 (en) 1999-05-21 2006-03-28 Micro Therapeutics, Inc. Threaded syringe with quick stop
EP1949890A3 (en) 1999-06-04 2011-05-18 ALZA Corporation Implantable gel compositions and method of manufacture
AU779277B2 (en) * 1999-06-04 2005-01-13 Alza Corporation Implantable gel compositions and method of manufacture
AU6058000A (en) * 1999-07-12 2001-01-30 Scimed Life Systems, Inc. Liquid based vaso-occlusive compositions
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
FR2802923B1 (en) * 1999-12-28 2002-03-08 Roquette Freres PROCESS FOR THE PREPARATION OF A LACTIC ACID ESTER COMPOSITION AND ITS USE AS A SOLVENT
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US6998137B2 (en) * 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
KR100794081B1 (en) * 2000-04-12 2008-01-10 산꼬 가가꾸 고교 가부시끼가이샤 Antistatic Composition
AU5911101A (en) 2000-04-19 2001-10-30 Genentech Inc Sustained release formulations
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
AU2001245346A1 (en) * 2000-06-28 2002-01-08 Atul J. Shukla Biodegradable vehicles and delivery systems of biologically active substances
US20060177416A1 (en) * 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
US20020106406A1 (en) * 2000-12-08 2002-08-08 Mchugh Anthony J. Crystallizable/non-crystallizable polymer composites
US7088002B2 (en) * 2000-12-18 2006-08-08 Intel Corporation Interconnect
JP2004516262A (en) 2000-12-21 2004-06-03 ネクター セラピューティクス Induced phase transition method for the production of microparticles containing hydrophilic activators
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US6500408B2 (en) 2001-01-27 2002-12-31 Jc Technologies, Inc. Enamel-safe tooth bleach and method for use
WO2002067991A1 (en) 2001-02-23 2002-09-06 Genentech, Inc. Erodible polymers for injection
WO2002068676A2 (en) * 2001-02-27 2002-09-06 University Of Rochester METHODS AND COMPOSITIONS FOR MODIFYING APOLIPOPROTEIN B mRNA EDITING
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
IL159048A0 (en) * 2001-06-21 2004-05-12 Genentech Inc Sustained release formulation
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
US7342089B2 (en) * 2001-07-11 2008-03-11 Palatin Technologies, Inc. Cyclic peptides for treatment for cachexia
US7345144B2 (en) * 2001-07-11 2008-03-18 Palatin Technologies, Inc. Cyclic peptides for treatment of cachexia
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
JP2005504043A (en) * 2001-08-10 2005-02-10 パラチン テクノロジーズ インク． Peptidomimetics of biologically active metal peptides
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
GB2404865B (en) * 2001-09-11 2005-09-28 Caretek Medical Ltd Novel drug delivery technology
GB0122318D0 (en) * 2001-09-14 2001-11-07 Novartis Ag Organic compounds
ITMI20012060A1 (en) * 2001-10-05 2003-04-05 Recordati Chem Pharm NEW N-ACYLATED HETEROCYCLES
BR0206469A (en) * 2001-11-14 2004-01-13 Alza Corp Injectable Depot Composition
DE60239556D1 (en) * 2001-11-14 2011-05-05 Durect Corp CATHETERINJICIBLE DEPOT COMPOSITIONS AND THEIR USE
KR20040058100A (en) * 2001-11-14 2004-07-03 알자 코포레이션 Injectable depot compositions and uses thereof
KR100629380B1 (en) * 2001-11-30 2006-09-29 화이자 인코포레이티드 Controlled release polymeric compositions of bone growth promoting compounds
WO2003070219A1 (en) * 2002-02-22 2003-08-28 Santen Pharmaceutical Co., Ltd. Drug delivery system for the subconjunctival administration of fine grains
ES2207387B1 (en) * 2002-02-28 2005-07-16 Consejo Sup. Investig. Cientificas CHEMICAL COMPOSITION OF IGF-I FOR THE TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES.
US6960346B2 (en) * 2002-05-09 2005-11-01 University Of Tennessee Research Foundation Vehicles for delivery of biologically active substances
US7432245B2 (en) * 2002-06-07 2008-10-07 Abbott Laboratories Inc. Pharmaceutical formulation comprising a peptide angiogenesis inhibitor
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AR039729A1 (en) 2002-06-25 2005-03-09 Alza Corp SHORT-TERM DEPOSIT FORMULATIONS
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
CA2490007C (en) * 2002-07-19 2011-05-24 Omeros Corporation Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from
DE60325742D1 (en) * 2002-07-31 2009-02-26 Alza Corp INJECTABLE MULTIMODAL POLYMERS DEPOT COMPOSITIONS AND THEIR USES
CA2494342A1 (en) * 2002-07-31 2004-02-12 Alza Corporation Injectable depot compositions and uses thereof
WO2004013160A2 (en) * 2002-08-05 2004-02-12 University Of Rochester Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
CA2498276A1 (en) * 2002-10-25 2004-05-06 Pfizer Products Inc. Depot formulations of arylheterocyclic active agents in the form of a suspension
AU2003285075B2 (en) * 2002-10-29 2009-10-29 Durect Corporation Stabilized, solid-state polypeptide particles
US6918561B2 (en) * 2002-10-31 2005-07-19 Yon So Chong Shell assembly for winding tire cord strip or belt cord strip
NZ539810A (en) 2002-11-06 2008-03-28 Alza Corp Controlled release injectable depot formulations
JP2004196787A (en) * 2002-12-04 2004-07-15 Santen Pharmaceut Co Ltd Drug delivery system with subconjunctival depot
US20060039979A1 (en) * 2002-12-04 2006-02-23 Kazuhito Yamada Drug delivery system using subconjunctival depot
RU2342118C2 (en) * 2002-12-19 2008-12-27 Алза Корпорейшн Stable nonaqueous single-phase gels and compositions on their basis for delivery from implanted device
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
DK2526996T3 (en) 2002-12-20 2019-12-02 Xeris Pharmaceuticals Inc Formulation for intracutaneous injection
ES2282529T3 (en) * 2003-02-03 2007-10-16 Hans-Dietrich Dr.Techn. Polaschegg COMPOSITION FOR THE PREVENTION OF AN INFECTION DUE TO A PERMANENT DEVICE.
US6878374B2 (en) 2003-02-25 2005-04-12 Nitto Denko Corporation Biodegradable polyacetals
WO2004081196A2 (en) * 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
DE10314082A1 (en) * 2003-03-28 2004-10-21 Mcs Micro Carrier Systems Gmbh Biodegradable injectable implant
TW200507893A (en) * 2003-03-31 2005-03-01 Alza Corp Osmotic pump with means for dissipating internal pressure
EP1610761A2 (en) * 2003-03-31 2006-01-04 Alza Corporation Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
RU2005133427A (en) * 2003-03-31 2006-04-27 Алза Корпорейшн (Us) WATERLESS SINGLE-PHASE CARRIERS AND DRUGS USING SUCH CARRIERS
TW584939B (en) * 2003-04-23 2004-04-21 Nanya Technology Corp Method of forming bottle-shaped trench and the method for fabricating bottle-shaped trench capacitors
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
AR044437A1 (en) * 2003-05-29 2005-09-14 Schering Plough Ltd COMPOSITIONS AND METHOD FOR TREATMENT OF INFECTIONS IN VACCINE AND PORCINE LIVESTOCK
AU2004245022A1 (en) * 2003-05-30 2004-12-16 Alza Corporation Implantable elastomeric depot compositions, uses thereof and method of manufacturing
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
WO2005002625A2 (en) 2003-06-26 2005-01-13 Control Delivery Systems, Inc. In-situ gelling drug delivery system
CA2530113C (en) * 2003-06-26 2013-08-13 Control Delivery Systems, Inc. Bioerodible sustained release drug delivery systems
US20060286173A1 (en) * 2003-08-20 2006-12-21 Kazuhito Yamada Drug delivery system for sub-tenon s capsule adminstration of fine grains
US7048925B2 (en) 2003-08-28 2006-05-23 Nitto Denko Corporation Acid-sensitive polyacetals and methods
WO2005023985A2 (en) * 2003-09-03 2005-03-17 University Of Rochester Cytidine deaminase activators, deoxycytidine deaminase activators, vif antagonists, and methods of screening for molecules thereof
WO2005032597A1 (en) 2003-09-29 2005-04-14 Nitto Denko Corporation Biodegradable polyacetals for in vivo polynucleotide delivery
AU2004287439A1 (en) * 2003-10-29 2005-05-19 Idexx Laboratories, Inc. Salts of pharmacologically active compounds
US20050118206A1 (en) * 2003-11-14 2005-06-02 Luk Andrew S. Surfactant-based gel as an injectable, sustained drug delivery vehicle
CN1889929B (en) * 2003-11-14 2013-04-10 阿尔萨公司 Excipients in drug delivery vehicles
US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
AU2005206143B2 (en) * 2004-01-12 2010-12-16 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
US8221778B2 (en) * 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
EP1711517A4 (en) 2004-01-21 2008-02-13 Univ Utah Res Found MUTANT SODIUM CHANNEL NAv1.7 AND METHODS RELATED THERETO
US7429391B2 (en) * 2004-01-30 2008-09-30 Access Business Group International Llc Holistic composition and method for reducing skin pigmentation
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US20080248465A1 (en) * 2004-04-26 2008-10-09 Uab Research Foundation Polymorphisms in the Fcgr2b Promoter and Uses Thereof
WO2005115410A2 (en) * 2004-05-06 2005-12-08 University Of Rochester Context dependent inhibitors of cytidine deaminases and uses thereof
US7879320B2 (en) * 2004-05-17 2011-02-01 Ares Trading S.A. Hydrogel interferon formulations
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
EP1750751B1 (en) * 2004-06-01 2013-04-10 Ares Trading S.A. Stabilized interferon liquid formulations
US7858115B2 (en) * 2004-06-24 2010-12-28 Idexx Laboratories Phospholipid gel compositions for drug delivery and methods of treating conditions using same
US7854943B2 (en) * 2004-06-24 2010-12-21 Idexx Laboratories Phospholipid gel compositions for drug delivery and methods of treating conditions using same
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006032202A1 (en) * 2004-09-21 2006-03-30 Shandong Luye Pharmaceutical Co., Ltd. Long acting sustained-release formulation containing dopamine receptor agonist and the preparation method thereof
US8541413B2 (en) * 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
US9993558B2 (en) 2004-10-01 2018-06-12 Ramscor, Inc. Sustained release eye drop formulations
JP5682991B2 (en) * 2004-10-01 2015-03-11 ラムズコア， インコーポレイテッド Convenient implantable sustained release drug formulation
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
AR052155A1 (en) * 2004-12-14 2007-03-07 Novartis Ag ORGANIC COMPOUNDS
GB0428151D0 (en) 2004-12-22 2005-01-26 Novartis Ag Organic compounds
US20060141040A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
CN100425233C (en) * 2005-01-12 2008-10-15 复旦大学 Nimodipine gel for nasal cavity
EP1853221A2 (en) * 2005-02-03 2007-11-14 Duramed Pharmaceuticals, Inc. Devices for delivering agents to a vaginal tract
US20060216242A1 (en) * 2005-02-03 2006-09-28 Rohloff Catherine M Suspending vehicles and pharmaceutical suspensions for drug dosage forms
WO2006084141A2 (en) * 2005-02-03 2006-08-10 Intarcia Therapeutics, Inc Suspension formulation of interferon
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US7674452B2 (en) 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
US20060253068A1 (en) * 2005-04-20 2006-11-09 Van Bilsen Paul Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart
US20070015689A1 (en) * 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
EP1741440A1 (en) * 2005-07-08 2007-01-10 Mellitus S.L. Use of BPI protein for the treatment of disorders of the metabolism and cardiovascular disorders
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
CA2618404A1 (en) * 2005-08-04 2007-02-15 Angiotech International Ag Block copolymer compositions and uses thereof
US20070048288A1 (en) * 2005-08-30 2007-03-01 Lyu Suping Shear thinning polymer cell delivery compositions
JP5192384B2 (en) 2005-09-22 2013-05-08 メディバス エルエルシー Bis- (α-amino) -diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use
WO2007038246A2 (en) * 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US8852638B2 (en) * 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US7669732B2 (en) * 2005-10-25 2010-03-02 Imi Cornelius Inc. Cup lid dispenser
WO2007058190A1 (en) * 2005-11-16 2007-05-24 Tokai University Educational System Controlled drug release composition and drug releasing medical device
EP1962894A4 (en) * 2005-12-07 2012-11-14 Medivas Llc Method for assembling a polymer-biologic delivery composition
US20070142287A1 (en) * 2005-12-20 2007-06-21 Biomed Solutions, Llc Compositions And Methods For Treatment Of Cancer
US20070184087A1 (en) 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
US7622440B2 (en) 2006-03-30 2009-11-24 Palatin Technologies, Inc. Cyclic natriuretic peptide constructs
US7795221B2 (en) * 2006-03-30 2010-09-14 Palatin Technologies, Inc. Linear natriuretic peptide constructs
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
JP5445130B2 (en) * 2006-05-02 2014-03-19 メディバス エルエルシー Delivery of ophthalmic drugs to the exterior or interior of the eye
JP5196498B2 (en) * 2006-05-09 2013-05-15 メディバス エルエルシー Biodegradable water-soluble polymer
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
EP2051591B1 (en) 2006-08-07 2016-04-20 Novozymes A/S Enzyme granules for animal feed
ES2576580T3 (en) 2006-08-07 2016-07-08 Novozymes A/S Enzyme granules for animal feed
CN102274557B (en) 2006-08-09 2014-12-03 精达制药公司 Osmotic delivery systems and piston assemblies
US20080038332A1 (en) * 2006-08-10 2008-02-14 Cai Gu Huang Stable pharmaceutical formulation comprising atorvastatin calcium
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
US8999317B2 (en) 2006-11-01 2015-04-07 University Of Rochester Methods and compositions related to the structure and function of APOBEC3G
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
KR100825519B1 (en) * 2007-01-05 2008-04-25 주식회사 바이오폴리메드 A chitosan based polymer conjugate and a method for producing the same
NZ580447A (en) * 2007-04-23 2011-06-30 Intarcia Therapeutics Inc Suspension formulations of insulinotropic peptides and uses thereof
ES2606951T3 (en) 2007-05-18 2017-03-28 Durect Corporation Enhanced extended release formulations
CN101801415B (en) 2007-05-25 2015-09-23 Rb医药品有限公司 The sustained delivery formulations of risperidone compounds
US10092524B2 (en) * 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
US20090029937A1 (en) * 2007-07-24 2009-01-29 Cornell University Biodegradable cationic polymer gene transfer compositions and methods of use
US8470360B2 (en) * 2008-04-18 2013-06-25 Warsaw Orthopedic, Inc. Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
MX2010004366A (en) * 2007-11-05 2010-05-05 Bausch & Lomb Water-immiscible materials as vehicles for drug delivery.
WO2009060473A2 (en) * 2007-11-06 2009-05-14 Panacea Biotec Limited Injectable compositions, processes and uses thereof
CA2705520C (en) * 2007-11-13 2016-06-28 Surmodics Pharmaceuticals, Inc. Viscous terpolymers as drug delivery platform
WO2009080699A2 (en) * 2007-12-20 2009-07-02 Merck Serono S.A. Peg-interferon-beta formulations
US20090181068A1 (en) * 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
KR20100121484A (en) * 2008-02-15 2010-11-17 본 테라퓨틱스 소시에테아노님 Pharmaceutical composition for use in the treatment or prevention of osteoarticular diseases
WO2009101194A1 (en) 2008-02-15 2009-08-20 Bone Therapeutics Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases
US8828354B2 (en) * 2008-03-27 2014-09-09 Warsaw Orthopedic, Inc. Pharmaceutical gels and methods for delivering therapeutic agents to a site beneath the skin
US8629172B2 (en) 2008-04-18 2014-01-14 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising clonidine
US8889173B2 (en) * 2008-04-18 2014-11-18 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of pain and/or inflammation
US9132085B2 (en) * 2008-04-18 2015-09-15 Warsaw Orthopedic, Inc. Compositions and methods for treating post-operative pain using clonidine and bupivacaine
US20090263443A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedics, Inc. Methods for treating post-operative effects such as spasticity and shivering with clondine
US9132119B2 (en) 2008-04-18 2015-09-15 Medtronic, Inc. Clonidine formulation in a polyorthoester carrier
US20090264477A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc., An Indiana Corporation Beta adrenergic receptor agonists for treatment of pain and/or inflammation
US8557273B2 (en) * 2008-04-18 2013-10-15 Medtronic, Inc. Medical devices and methods including polymers having biologically active agents therein
US9289409B2 (en) * 2008-04-18 2016-03-22 Warsaw Orthopedic, Inc. Sulindac formulations in a biodegradable material
US8846068B2 (en) * 2008-04-18 2014-09-30 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising a local anesthetic
US8883768B2 (en) * 2008-04-18 2014-11-11 Warsaw Orthopedic, Inc. Fluocinolone implants to protect against undesirable bone and cartilage destruction
US8956641B2 (en) 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of inflammatory diseases
US9072727B2 (en) 2008-04-18 2015-07-07 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for treatment of degenerative disc disease
US8420114B2 (en) 2008-04-18 2013-04-16 Warsaw Orthopedic, Inc. Alpha and beta adrenergic receptor agonists for treatment of pain and / or inflammation
US9125917B2 (en) * 2008-04-18 2015-09-08 Warsaw Orthopedic, Inc. Fluocinolone formulations in a biodegradable polymer carrier
US8956636B2 (en) 2008-04-18 2015-02-17 Warsaw Orthopedic, Inc. Methods and compositions for treating postoperative pain comprosing ketorolac
US20090264478A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Sulfasalazine formulations in a biodegradable polymer carrier
US20090264489A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Method for Treating Acute Pain with a Formulated Drug Depot in Combination with a Liquid Formulation
US8524267B2 (en) * 2008-04-18 2013-09-03 Warsaw Orthopedic, Inc. Dexamethasone formulations in a biodegradable material
US8722079B2 (en) 2008-04-18 2014-05-13 Warsaw Orthopedic, Inc. Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US20100015049A1 (en) * 2008-07-16 2010-01-21 Warsaw Orthopedic, Inc. Methods and compositions for treating postoperative pain comprising nonsteroidal anti-inflammatory agents
US20100016808A1 (en) * 2008-07-17 2010-01-21 Bioform Medical, Inc. Thin-Walled Delivery System
US9492375B2 (en) * 2008-07-23 2016-11-15 Warsaw Orthopedic, Inc. Foam carrier for bone grafting
WO2010019716A1 (en) * 2008-08-13 2010-02-18 Medivas, Llc Aabb-poly(depsipeptide) biodegradable polymers and methods of use
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
CN102281865B (en) * 2008-10-15 2017-04-05 精达制药公司 Highly enriched drug particles, preparation, suspensoid and its application
US20100098746A1 (en) * 2008-10-20 2010-04-22 Warsaw Orthopedic, Inc. Compositions and methods for treating periodontal disease comprising clonidine, sulindac and/or fluocinolone
US9161903B2 (en) 2008-10-31 2015-10-20 Warsaw Orthopedic, Inc. Flowable composition that hardens on delivery to a target tissue site beneath the skin
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
ES2549158T3 (en) 2008-11-11 2015-10-23 Signum Biosciences, Inc. Isoprenyl compounds and methods thereof
WO2010065801A1 (en) 2008-12-04 2010-06-10 Palatin Technologies, Inc. Amine substituted piperazine melanocortin receptor-specific compounds
WO2010065802A2 (en) 2008-12-04 2010-06-10 Palatin Technologies, Inc. Substituted pyrrolidine or imidazolidine melanocortin receptor-specific compounds
WO2010065799A2 (en) 2008-12-04 2010-06-10 Palatin Technologies, Inc. Amine substituted piperidine melanocortin receptor-specific compounds
US9480643B2 (en) 2008-12-23 2016-11-01 Surmodics Pharmaceuticals, Inc. Implantable composites and implants comprising same
US9415197B2 (en) * 2008-12-23 2016-08-16 Surmodics, Inc. Implantable suction cup composites and implants comprising same
US8974808B2 (en) * 2008-12-23 2015-03-10 Surmodics, Inc. Elastic implantable composites and implants comprising same
US20100168807A1 (en) * 2008-12-23 2010-07-01 Burton Kevin W Bioactive terpolymer compositions and methods of making and using same
US8951546B2 (en) * 2008-12-23 2015-02-10 Surmodics Pharmaceuticals, Inc. Flexible implantable composites and implants comprising same
US8980317B2 (en) 2008-12-23 2015-03-17 Warsaw Orthopedic, Inc. Methods and compositions for treating infections comprising a local anesthetic
US20100228097A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Methods and compositions to diagnose pain
US20100226959A1 (en) * 2009-03-04 2010-09-09 Warsaw Orthopedic, Inc. Matrix that prolongs growth factor release
US20100239632A1 (en) * 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
AU2010259008C1 (en) 2009-06-08 2016-04-21 Palatin Technologies, Inc. Melanocortin receptor-specific peptides
US8617583B2 (en) 2009-07-17 2013-12-31 Warsaw Orthopedic, Inc. Alpha adrenergic receptor agonists for prevention or treatment of a hematoma, edema, and/or deep vein thrombosis
US8653029B2 (en) 2009-07-30 2014-02-18 Warsaw Orthopedic, Inc. Flowable paste and putty bone void filler
US8231891B2 (en) 2009-07-31 2012-07-31 Warsaw Orthopedic, Inc. Implantable drug depot for weight control
WO2011015958A2 (en) 2009-08-06 2011-02-10 Koninklijke Philips Electronics N.V. Oncology therapies employing radioactive seeds
CA2775676C (en) 2009-09-28 2016-08-16 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US20110097375A1 (en) 2009-10-26 2011-04-28 Warsaw Orthopedic, Inc. Formulation for preventing or reducing bleeding at a surgical site
US20110097380A1 (en) * 2009-10-28 2011-04-28 Warsaw Orthopedic, Inc. Clonidine formulations having antimicrobial properties
US9504698B2 (en) * 2009-10-29 2016-11-29 Warsaw Orthopedic, Inc. Flowable composition that sets to a substantially non-flowable state
US8597192B2 (en) 2009-10-30 2013-12-03 Warsaw Orthopedic, Inc. Ultrasonic devices and methods to diagnose pain generators
CN102655745B (en) 2009-11-12 2016-01-06 西格纳姆生物科学公司 Antibacterial agent is used for the treatment of the purposes of epithelial-related disease condition
US9993441B2 (en) 2009-12-30 2018-06-12 Surmodics, Inc. Controlled release matrix barrier structure for subcutaneous medical devices
US8758791B2 (en) * 2010-01-26 2014-06-24 Warsaw Orthopedic, Inc. Highly compression resistant matrix with porous skeleton
US8475824B2 (en) * 2010-01-26 2013-07-02 Warsaw Orthopedic, Inc. Resorbable matrix having elongated particles
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
US9125902B2 (en) * 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9486500B2 (en) 2010-01-28 2016-11-08 Warsaw Orthopedic, Inc. Osteoimplant and methods for making
US20110229457A1 (en) * 2010-03-12 2011-09-22 Surmodics, Inc. Injectable drug delivery system
CN102844427B (en) * 2010-03-17 2016-07-06 小利兰·斯坦福大学托管委员会 Photo-sensitive ion permeability molecule
US10285936B2 (en) 2010-05-31 2019-05-14 Laboratorios Farmacéuticos Rovi, S.A. Injectable composition with aromatase inhibitor
US10350159B2 (en) 2010-05-31 2019-07-16 Laboratories Farmacéuticos Rovi, S.A. Paliperidone implant formulation
US10335366B2 (en) 2010-05-31 2019-07-02 Laboratorios Farmacéuticos Rovi, S.A. Risperidone or paliperidone implant formulation
US10881605B2 (en) 2010-05-31 2021-01-05 Laboratorios Farmaceuticos Rovi, S.A. Methods for the preparation of injectable depot compositions
PT2394664T (en) 2010-05-31 2016-09-06 Farm Rovi Lab Sa Antipsychotic injectable depot composition
US10463607B2 (en) 2010-05-31 2019-11-05 Laboratorios Farmaceutics Rofi S.A. Antipsychotic Injectable Depot Composition
HRP20211853T1 (en) 2010-05-31 2022-03-04 Laboratorios Farmaceuticos Rovi, S.A. Compositions for injectable in-situ biodegradable implants
US9364518B2 (en) * 2010-06-24 2016-06-14 Torrent Pharmaceuticals Limited Pharmaceutical composition containing goserelin for in-situ implant
US20120046225A1 (en) 2010-07-19 2012-02-23 The Regents Of The University Of Colorado, A Body Corporate Stable glucagon formulations for the treatment of hypoglycemia
US8246571B2 (en) 2010-08-24 2012-08-21 Warsaw Orthopedic, Inc. Drug storage and delivery device having a retaining member
WO2012030822A1 (en) 2010-08-30 2012-03-08 Surmodics Pharmaceuticals, Inc. Process for reducing moisture in a biodegradable implant device
US11058796B2 (en) 2010-10-20 2021-07-13 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US10525169B2 (en) 2010-10-20 2020-01-07 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
WO2015095745A1 (en) 2010-10-20 2015-06-25 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11207109B2 (en) 2010-10-20 2021-12-28 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US11291483B2 (en) 2010-10-20 2022-04-05 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
WO2012054742A2 (en) 2010-10-20 2012-04-26 BIOS2 Medical, Inc. Implantable polymer for bone and vascular lesions
US11484627B2 (en) 2010-10-20 2022-11-01 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
US9320601B2 (en) 2011-10-20 2016-04-26 206 Ortho, Inc. Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants
US9414930B2 (en) 2010-10-26 2016-08-16 Kyphon SÀRL Activatable devices containing a chemonucleolysis agent
US8404268B2 (en) 2010-10-26 2013-03-26 Kyphon Sarl Locally targeted anti-fibrotic agents and methods of use
US8740982B2 (en) 2010-10-26 2014-06-03 Kyphon Sarl Devices containing a chemonucleolysis agent and methods for treating an intervertebral disc or spinal arachnoiditis
CN103313733A (en) 2010-11-15 2013-09-18 捷迈整形外科生物材料有限公司 Bone void fillers
WO2012075451A2 (en) 2010-12-03 2012-06-07 Warsaw Orthopedic, Inc. Clonidine and gaba compounds in a biodegradable polymer carrier
US8623396B2 (en) 2010-12-03 2014-01-07 Warsaw Orthopedic, Inc. Compositions and methods for delivering clonidine and bupivacaine to a target tissue site
US9060978B2 (en) 2011-01-24 2015-06-23 Warsaw Orthopedic, Inc. Method for treating an intervertebral disc disorder by administering a dominant negative tumor necrosis factor antagonist
US9717779B2 (en) 2011-01-31 2017-08-01 Warsaw Orthopedic, Inc. Implantable matrix having optimum ligand concentrations
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
KR101978527B1 (en) 2011-03-10 2019-09-03 엑스에리스 파머수티클스, 인크. Stable formulations for parenteral injection of peptide drugs
AU2012240131B2 (en) * 2011-04-05 2017-07-20 Edge Therapeutics Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow
US9511077B2 (en) 2011-04-25 2016-12-06 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for wound healing
US9592243B2 (en) 2011-04-25 2017-03-14 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for treatment of an injury
CA2839526A1 (en) 2011-06-23 2012-12-27 Dsm Ip Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US9132194B2 (en) 2011-07-12 2015-09-15 Warsaw Orthopedic, Inc. Medical devices and methods comprising an adhesive sheet containing a drug depot
US9205241B2 (en) 2011-07-12 2015-12-08 Warsaw Orthopedic, Inc. Medical devices and methods comprising an adhesive material
MX349383B (en) 2011-10-31 2017-07-26 Xeris Pharmaceuticals Inc Formulations for the treatment of diabetes.
MX364864B (en) * 2012-01-23 2019-05-09 Allergan Inc Time released biodegradable or bioerodible microspheres or microparticles suspended in a solidifying depot-forming injectable drug formulation.
US9534018B2 (en) 2012-03-13 2017-01-03 Tensive Controls Inc. Melanocortin analogs having enhanced activity and transport
US9511018B2 (en) 2012-04-05 2016-12-06 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable matrix
US8735504B2 (en) 2012-05-02 2014-05-27 Warsaw Orthopedic, Inc. Methods for preparing polymers having low residual monomer content
US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
US8835601B2 (en) * 2012-12-21 2014-09-16 Mayo Foundation For Medical Education And Research Natriuretic polypeptide delivery systems
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
US9018162B2 (en) 2013-02-06 2015-04-28 Xeris Pharmaceuticals, Inc. Methods for rapidly treating severe hypoglycemia
US20140308352A1 (en) 2013-03-11 2014-10-16 Zogenix Inc. Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
CN109602692B (en) 2013-03-11 2022-11-04 度瑞公司 Injectable controlled release compositions comprising high viscosity liquid carriers
KR102370470B1 (en) 2013-03-15 2022-03-04 헤론 테라퓨틱스 인코포레이티드 Compositions of a polyorthoester and an aprotic solvent
EP2999747B1 (en) 2013-05-23 2020-08-12 206 ORTHO, Inc. Apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
US10080877B2 (en) 2014-07-25 2018-09-25 Warsaw Orthopedic, Inc. Drug delivery device and methods having a drug cartridge
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
JP6982495B2 (en) 2014-08-06 2021-12-17 ゼリス ファーマシューティカルズ インコーポレイテッド Syringes, kits, and methods for intradermal and / or subcutaneous injection of paste
WO2016044683A1 (en) 2014-09-19 2016-03-24 Tensive Controls, Inc. Anti-microbial peptides
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CA2969171C (en) 2014-12-18 2023-12-12 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
CN107427670B (en) * 2014-12-29 2021-04-16 波士顿科学国际有限公司 Compositions, devices and methods for multi-stage release of chemotherapeutic agents
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
CN113598842A (en) 2015-06-03 2021-11-05 因塔西亚制药公司 Implant placement and removal system
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
EP3458084B1 (en) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US10549081B2 (en) 2016-06-23 2020-02-04 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
CN109477044B (en) 2016-07-19 2021-10-08 艺康美国股份有限公司 Method and cleaning solution for removing chewing gum and other sticky food
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
KR20190104039A (en) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Methods Including Continuous Administration of GLP-1 Receptor Agonists and Co-administration of Drugs
KR102646865B1 (en) 2017-06-02 2024-03-11 엑스에리스 파머수티클스, 인크. Precipitation-resistant small molecule drug formulation
CN107595765A (en) * 2017-09-22 2018-01-19 沈阳兴齐眼药股份有限公司 A kind of ophthalmically acceptable sustained release drug delivery system and preparation method thereof
US20210121428A1 (en) * 2019-10-25 2021-04-29 Warsaw Orthopedic, Inc. Compositions for treatment of annular spinal disc injury
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CN112516372A (en) * 2020-11-12 2021-03-19 盐城工学院 Composite drug-loaded fiber for absorbable surgical suture
AU2022343289A1 (en) 2021-09-09 2024-02-29 Xeris Pharmaceuticals, Inc. Injectable high concentration pharmaceutical formulations and methods of manufacturing and use thereof
AU2022351480A1 (en) 2021-09-21 2024-03-28 Laboratorios Farmacéuticos Rovi, S.A. Antipsychotic injectable extended-release composition

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003768A1 (en) * 1988-10-03 1990-04-19 Southern Research Institute Biodegradable in-situ forming implants
WO1991005544A1 (en) * 1989-10-23 1991-05-02 Medinvent Drug delivery system, method for preparing the same, and use thereof
EP0539751A1 (en) * 1991-10-28 1993-05-05 Atrix Laboratories, Inc. Biodegradable polymer composition
US5242910A (en) * 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
EP0640647A2 (en) * 1993-08-26 1995-03-01 Collagen Corporation Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery
WO1995027481A1 (en) * 1994-04-08 1995-10-19 Atrix Laboratories, Inc. Liquid delivery compositions
WO1997015287A1 (en) * 1995-10-25 1997-05-01 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester) block copolymers

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35338A (en) * 1862-05-20 Improvement in catamenial and urinal bandages and receptacles
FR2065764A5 (en) * 1969-10-29 1971-08-06 Dev Investisse Controlled emission insecticidal vapourisingstrips
FR2077679A7 (en) * 1970-02-04 1971-11-05 Boullenger Yvette Volatile pesticide dispensers - with evaporation rate controlled with hydrophobic esters
BE758156R (en) * 1970-05-13 1971-04-28 Ethicon Inc ABSORBABLE SUTURE ELEMENT AND ITS
US3714228A (en) * 1970-08-14 1973-01-30 Universal Oil Prod Co Preparation of esters
US3792010A (en) * 1972-03-27 1974-02-12 Ethicon Inc Plasticized polyester sutures
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3923939A (en) 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4443340A (en) * 1981-10-09 1984-04-17 Betz Laboratories, Inc. Control of iron induced fouling in water systems
DE3324192A1 (en) * 1983-07-05 1985-01-17 Troponwerke Gmbh & Co Kg DEPOT ANTIPHLOGISTICS
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
US4985404A (en) * 1984-10-04 1991-01-15 Monsanto Company Prolonged release of biologically active polypeptides
EP0226061B1 (en) * 1985-12-17 1994-02-16 United States Surgical Corporation High molecular weight bioresorbable polymers and implantation devices thereof
US4865845A (en) * 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US5227157A (en) 1986-10-14 1993-07-13 Board Of Regents, The University Of Texas System Delivery of therapeutic agents
DE3635679A1 (en) 1986-10-21 1988-05-05 Dynamit Nobel Ag Surgical suture material
US4981696A (en) 1986-12-22 1991-01-01 E. I. Du Pont De Nemours And Company Polylactide compositions
US4853218A (en) * 1987-02-24 1989-08-01 Schering Corporation Zinc-protamine-alpha interferon complex
US5229422A (en) * 1987-09-07 1993-07-20 Teijin Limited Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5632727A (en) 1988-10-03 1997-05-27 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US5725491A (en) * 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5633002A (en) 1988-10-04 1997-05-27 Boehringer Ingelheim Gmbh Implantable, biodegradable system for releasing active substance
US5085866A (en) * 1988-12-02 1992-02-04 Southern Research Institute Method of producing zero-order controlled-released devices
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5091188A (en) 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
CA2065156A1 (en) * 1990-07-03 1992-01-04 Richard L. Dunn Intragingival delivery systems for treatment of periodontal disease
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5151093A (en) * 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
GB9027422D0 (en) * 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5292782A (en) 1991-02-20 1994-03-08 Novamont S.P.A. Biodegradable polymeric compositions based on starch and thermoplastic polymers
SE9100610D0 (en) * 1991-03-04 1991-03-04 Procordia Ortech Ab BIORESORBABLE MATERIAL FOR MEDICAL USE
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5288214A (en) * 1991-09-30 1994-02-22 Toshio Fukuda Micropump
AU2605592A (en) * 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
WO1993012160A1 (en) * 1991-12-19 1993-06-24 Mitsui Toatsu Chemicals, Inc. Polyhydroxy carboxylic acid and production thereof
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5456679A (en) * 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5209746A (en) * 1992-02-18 1993-05-11 Alza Corporation Osmotically driven delivery devices with pulsatile effect
EP0560014A1 (en) 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US5656297A (en) * 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
EP0633907A1 (en) 1992-03-30 1995-01-18 Alza Corporation Additives for bioerodible polymers to regulate degradation
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5711968A (en) * 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US5674534A (en) * 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
WO1994012158A1 (en) * 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5681873A (en) 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
JPH07188059A (en) * 1993-12-28 1995-07-25 Rohto Pharmaceut Co Ltd Therapeutic agent for periodontosis
US5556905A (en) 1994-03-30 1996-09-17 Reilly Industries, Inc. Physically-modified degradable thermoplastic compositions
JPH09511666A (en) * 1994-04-08 1997-11-25 アトリックス・ラボラトリーズ・インコーポレイテッド Ancillary polymer systems for use in medical devices
FR2718642B1 (en) 1994-04-15 1996-07-12 Pf Medicament Biodegradable controlled release microspheres and their preparation process.
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
SE503644C2 (en) * 1994-10-14 1996-07-22 Eka Chemicals Ab Ways to determine the content of organic material in effluents from pulp and paper mills
WO1996021427A1 (en) * 1995-01-09 1996-07-18 Atrix Laboratories, Inc. Liquid polymer delivery system
CA2683230C (en) * 1995-02-13 2013-08-27 Intertrust Technologies Corporation Systems and methods for secure transaction management and electronic rights protection
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
AU3981097A (en) 1996-08-21 1998-03-06 Alkermes Controlled Therapeutics, Inc. Controlled release microparticles with a hydrophobic material
US6978370B1 (en) * 1996-09-03 2005-12-20 Cryptography Research, Inc. Method and system for copy-prevention of digital copyright works
DK0959873T3 (en) * 1996-12-20 2006-07-03 Alza Corp Gel composition and methods
US7233948B1 (en) * 1998-03-16 2007-06-19 Intertrust Technologies Corp. Methods and apparatus for persistent control and protection of content
US6697944B1 (en) * 1999-10-01 2004-02-24 Microsoft Corporation Digital content distribution, transmission and protection system and method, and portable device for use therewith
US7213005B2 (en) * 1999-12-09 2007-05-01 International Business Machines Corporation Digital content distribution using web broadcasting services
US6366907B1 (en) * 1999-12-15 2002-04-02 Napster, Inc. Real-time search engine
IL135555A0 (en) * 2000-04-09 2001-05-20 Vidius Inc Preventing unauthorized access to data sent via computer networks
US6947909B1 (en) * 2000-05-12 2005-09-20 Hoke Jr Clare L Distribution, recognition and accountability system for intellectual and copy written properties in digital media's

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003768A1 (en) * 1988-10-03 1990-04-19 Southern Research Institute Biodegradable in-situ forming implants
WO1991005544A1 (en) * 1989-10-23 1991-05-02 Medinvent Drug delivery system, method for preparing the same, and use thereof
EP0539751A1 (en) * 1991-10-28 1993-05-05 Atrix Laboratories, Inc. Biodegradable polymer composition
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5242910A (en) * 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
EP0640647A2 (en) * 1993-08-26 1995-03-01 Collagen Corporation Ionically crosslinked glycosaminoglycan gels for soft tissue augmentation and drug delivery
WO1995027481A1 (en) * 1994-04-08 1995-10-19 Atrix Laboratories, Inc. Liquid delivery compositions
WO1997015287A1 (en) * 1995-10-25 1997-05-01 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester) block copolymers

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992961B2 (en) 1999-02-08 2015-03-31 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US9233160B2 (en) 2002-12-13 2016-01-12 Durect Corporation Oral drug delivery system
US8945614B2 (en) 2002-12-13 2015-02-03 Durect Corporation Oral drug delivery system
US8951556B2 (en) 2002-12-13 2015-02-10 Durect Corporation Oral drug delivery system
US8974821B2 (en) 2002-12-13 2015-03-10 Durect Corporation Oral drug delivery system
US9517271B2 (en) 2002-12-13 2016-12-13 Durect Corporation Oral drug delivery system
US8846072B2 (en) 2004-09-17 2014-09-30 Durect Corporation Controlled delivery system
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9095553B2 (en) 2005-02-03 2015-08-04 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US8956644B2 (en) 2006-11-03 2015-02-17 Durect Corporation Transdermal delivery systems
US9592204B2 (en) 2007-12-06 2017-03-14 Durect Corporation Oral pharmaceutical dosage forms
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9572885B2 (en) 2013-03-15 2017-02-21 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability

Also Published As

Publication number Publication date
PT959873E (en) 2006-07-31
DK0959873T3 (en) 2006-07-03
CN1146402C (en) 2004-04-21
EP0959873A2 (en) 1999-12-01
PT949905E (en) 2001-12-28
US6673767B1 (en) 2004-01-06
EP0959873B1 (en) 2006-03-01
JP4642946B2 (en) 2011-03-02
AU5609798A (en) 1998-07-17
JP2001509146A (en) 2001-07-10
IL130532A0 (en) 2000-06-01
CN1240346A (en) 2000-01-05
AU739469B2 (en) 2001-10-11
HK1023950A1 (en) 2000-09-29
CA2275587C (en) 2006-10-24
CA2591581C (en) 2013-01-29
JP2010120952A (en) 2010-06-03
CA2275525C (en) 2011-02-08
JP2002512597A (en) 2002-04-23
US6130200A (en) 2000-10-10
JP2010095544A (en) 2010-04-30
ATE203157T1 (en) 2001-08-15
US20030044467A1 (en) 2003-03-06
NZ335851A (en) 2001-02-23
US20020034532A1 (en) 2002-03-21
AU5615498A (en) 1998-07-17
GR3036599T3 (en) 2001-12-31
ATE318580T1 (en) 2006-03-15
ES2158611T3 (en) 2001-09-01
EP0949905B1 (en) 2001-07-18
CA2275525A1 (en) 1998-07-02
US6331311B1 (en) 2001-12-18
WO1998027963A2 (en) 1998-07-02
CA2591581A1 (en) 1998-07-02
DK0949905T3 (en) 2001-10-22
CA2275587A1 (en) 1998-07-02
US6468961B1 (en) 2002-10-22
WO1998027962A2 (en) 1998-07-02
DE69735384D1 (en) 2006-04-27
DE69705746T2 (en) 2001-10-31
HK1020009A1 (en) 2000-03-10
DE69735384T2 (en) 2006-08-10
WO1998027963A3 (en) 1998-10-15
KR20000069564A (en) 2000-11-25
ES2256898T3 (en) 2006-07-16
EP0949905A2 (en) 1999-10-20
US20060013879A9 (en) 2006-01-19
KR100616793B1 (en) 2006-08-28
DE69705746D1 (en) 2001-08-23

Similar Documents

Publication Publication Date Title
WO1998027962A3 (en) Injectable depot gel composition and method of preparing the composition
ATE240718T1 (en) METHOD FOR PRODUCING MEDICINAL FORMS WITH CONTROLLED ACTIVE INGREDIENTS DELIVERY ON A POLYMER BASE
KR850007559A (en) Implantable Formulations of Regulatory Peptides
ATE200184T1 (en) MEDICINATED ANIMAL FEED
DE59901789D1 (en) Pigmentable, foamable gel
BR9712882A (en) Biodegradable heterophasic polymeric compositions
AU5290490A (en) Spray gel base and spray gel preparation using thereof
CA2176716A1 (en) Preparation of biodegradable microparticles containing a biologically active agent
CA2298470A1 (en) Emulsified bituminous binder
EP0972798A4 (en) Mixture composition of synthetic resin and rubber
EP0864312A3 (en) Two component kit and guttapercha post to be used in combination with the kit
WO1998025577A3 (en) Process for hydrating a gelling agent
CA2305492A1 (en) Reducing agent with several constituents comprising at least a composition in powder form containing an agent for reducing hair sulphur bonds and method for permanent setting of keratin fibres
WO2000024360A8 (en) Preparation and use of solidified oils
PT91649A (en) Process for the preparation of a powdered plastics composition
KR860002267A (en) Method of producing topical transdermal anesthetic composition
AU7053191A (en) Encapsulation of active substances in starch
KR850000968A (en) Method of Preparation of Skin Protective Composition
AU3776999A (en) Biologically-active microdispersion composition
IE800282L (en) Microporous bodies having agents occluded
WO2002083787A3 (en) Polymeric composition
GB1521691A (en) Oleoresin emulsions
KR960001219A (en) Biodegradable chitin fiber and preparation method thereof
BG102004A (en) Composition of tyrosine and polymerized allergen
JPS54124043A (en) Emulsification of liquid cis-1, 4-polyisoprene rubber

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2275587

Country of ref document: CA

Ref country code: CA

Ref document number: 2275587

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1997952507

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1997952507

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 1997952507

Country of ref document: EP