WO1998037928A1 - Device for magnetic resonance imagery and for treating hypothermia - Google Patents

Device for magnetic resonance imagery and for treating hypothermia Download PDF

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Publication number
WO1998037928A1
WO1998037928A1 PCT/EP1998/001073 EP9801073W WO9837928A1 WO 1998037928 A1 WO1998037928 A1 WO 1998037928A1 EP 9801073 W EP9801073 W EP 9801073W WO 9837928 A1 WO9837928 A1 WO 9837928A1
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Prior art keywords
arrangement according
antenna
coil
alternating
generating
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PCT/EP1998/001073
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German (de)
French (fr)
Inventor
Werner Alois Kaiser
Wilfried ANDRÄ
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Werner Alois Kaiser
Andrae Wilfried
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Publication of WO1998037928A1 publication Critical patent/WO1998037928A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia

Definitions

  • the invention relates to an arrangement for magnetic resonance (MR) examination and hyperthermia treatment of a body or a part of the body according to the preamble of the claims, which is used primarily for combating breast cancer.
  • MR magnetic resonance
  • Frija Superparamagnetic iron oxides as positive MR contrast agents: in vitro and in vivo-evidence. Magn. Res. Hnaging 11 (4), 509-519 (1993); B. Hamm, T. Staks, M. Taupitz, R. Maibauer, A. Speidel, A. Huppertz, T. Frenzel, R. Lawaczek, KJ Wolf, L. Lange: Contrast-enhanced MR imaging of liver and spieen: first experiences in humans with a new superparamagnetic iron oxide. J. Magn. Reson. Imaging 4 (5), 659-668 (1994).
  • MR examinations and hyperthermia treatments are carried out separately and in time.
  • the measurement of temperature changes e.g. B. by HT-Eüistrahlung, with MR methods, see US 5 492 122 A, and a fixed breast holder for Stereotactic localization of MRI findings in the breast of a patient, see DE 43 25 206 AI. It has not yet been possible to control the influence of elevated temperatures, for example on the effectiveness of local chemotherapy or magnetic field therapy, during a diagnosis and treatment process.
  • the invention is therefore based on the object of enabling control of magnetic field therapeutic and / or chemotherapeutic treatments by simultaneous or almost simultaneous MR imaging and thus preventing interim changes in the position of the body or part of the body.
  • the same substance can be used for hyperthermia and as a contrast agent for the MR examination to reduce stress on the body and to reduce the consumption of substances with magnetic particles.
  • the common carrier enables simultaneous imaging of tissue lesions and their treatment.
  • the device for generating the alternating field is arranged as close as possible to the body, that is to say between the at least one, preferably annular antenna and the body.
  • the electromagnetic alternating field required for hyperthermia can primarily be generated either as a magnetic field (by alternating currents flowing in a suitable conductor arrangement) or as an electric field (by charging electrodes).
  • the egg direction for generating the alternating magnetic field in the form of at least one coil made of a non-magnetic material, preferably copper.
  • the coil advantageously consists of copper tube through which a coolant flows.
  • a holding vessel preferably made of a flexible, non-conductive material, is essentially inside the coil provided, which is connected to an under-thickening device and which serves to keep the body part in an unchangeable position during the entire examination and treatment.
  • the egg direction for generating the alternating electric field preferably consists of two electrode plates, which can simultaneously serve as holding or pressing means for the body or body part and are further provided with an insulating layer at least on their surfaces facing the body or body part.
  • the distance of these holding means from one another can be adjusted for adaptation to the body part or body.
  • An advantageous, material-saving design of the arrangement according to the invention is obtained if the coil simultaneously serves as an antenna and device for generating the alternating magnetic field. The coil is then used for both MR examination and hyper ermia treatment.
  • FIG. 1 shows a first arrangement according to the invention, in which the MR examination and hyperthermia treatment are carried out using separate means,
  • FIG. 2 shows a second arrangement according to the invention, in which the means for hyperthermia treatment are designed as plate electrodes
  • FIG. 3 shows a third arrangement according to the invention, in which the MR examination and the hyperemia treatment are carried out with the same coil.
  • a female breast is used as an example of the body part.
  • a carrier 2 with flank parts 21, 22 for at least one ring-shaped antenna 3 and at least one coil 4 is arranged on a patient couch 1 that is partially shown.
  • An antenna 31 and a display device 32 are assigned to the antenna 3.
  • the coil 4 is connected to an alternating voltage generator 41, which supplies an alternating current> 100 A with a frequency of 0.1 to 1 MHz. It consists of a non-magnetizable copper tube, inside of which a KüMstoff 42 circulates through the action of a KüMstoffpump 43, which is connected to the coil 4 via coolant hoses 44.
  • the coil 4 is lined with a preferably flexible, electrically and magnetically inactive vessel 5 for a breast 6 which, at least in the region of the flank parts 21, 22, lies completely against the inner wall of the vessel.
  • the vessel 5 representing an examination room is connected via a vacuum hose 51 to a vacuum pump 52 which creates a desired negative pressure in the vessel 5, presses the breast 6 against the inner wall of the vessel and thus into a shape which is favorable for the subsequent process.
  • the breast 6 has been injected with a substance containing iron oxide particles, which concentrates for a limited time at the sites of the damaged tissue parts.
  • the breast 6 is first brought into a stable and favorable shape and position for the examination and treatment with the aid of the vessel 5, the vacuum hose 51 and the vacuum pump 52. Subsequently, the coil 4 is excited with the aid of the alternating voltage generator 41 and thus an alternating field is generated in the coil 4, which causes hyperthermia at the concentration points of the substance in the tissue. At the same time, the coolant circuit 42, 43 is activated. If, for example, the AC voltage field is applied within 10 minutes, it generates a temperature of 43 ° C. in the concentration points in 10 minutes, which temperature is maintained for 5 minutes. Thereafter the treatment is stopped.
  • the breast 6 can also in other ways, for. B. by compression from the outside.
  • 2 again shows a patient couch 1 with a carrier 2 with two flank parts 21, 22 in which there is an antenna 3 and in which two plate-shaped electrodes 7, 8 with associated rods 71, 81 in the direction of double arrows 72, 82 are arranged adjustable.
  • the electrodes are provided on their surfaces facing one another and a breast 6 with electrically insulating layers 73, 83.
  • a vacuum system 51, 52, as described for FIG. 1, is not necessary in this case.
  • the electric field is generated for heating the entire breast 6 between the electrodes 7 and 8. Otherwise, the treatment of the breast 6 and the display of the signals received by the antenna 3 is similar to that described in FIG. 1. During the warming of the breast 6, it can also be treated chemotherapeutically.
  • a breast 6 is held in position and shape stable by vacuum in a vessel 5, which is located in an examination room 9 between two flank parts 21, 22 and is surrounded by a coil 10, which generates a magnetic field on the one hand and to this Purpose is connected to an AC voltage generator 41, similar to that described in FIG. 1.
  • this coil 10 is an antenna which receives the signals triggered by the concentration points in the breast 6 and makes them visible in a display device 32, so that the determination of the tissue lesions by location and size, including their changes due to the treatment, is possible.
  • FIGS. 1 and 2 permit the MR examination in parallel or in series with the hyperthermia treatment; however, in this case, preference is given to the serial sequence of the processes in order to avoid their possibly adverse mutual influences. None changes in the unambiguity of the assignment of the examination results to the treatment results, because the breast 6 does not change its position and shape during the course of the processes. Otherwise, what has been said about FIGS. 1 and 2 applies analogously. All features shown in the description, the following claims and the drawing can be essential to the invention both individually and in any combination with one another.

Abstract

The invention contains a device for magnetic resonance imagery and for treating hypothermia of the body or parts thereof (6), which enables simultaneous or virtually simultaneous implementation of the above-mentioned processes and reduces the strains to which tested bodies (6) are submitted, including the consumption of substances for the purpose of the test. Furthermore, at least one antenna (3) and a device for creating an electromagnetic field are associated to a common support, and means (1, 2, 21, 22) are provided to maintain in a stationary state the body or body part concerned during the test and the treatment.

Description

Anordnung zur Magnetresonanz-Untersuchung und Hyperthermie- BehandlungArrangement for magnetic resonance examination and hyperthermia treatment
Beschreibungdescription
Die Erfindung betrifft eine Anordnung zur Magnetresonanz(MR)- Untersuchung und Hyperthermie-Behandlung eines Körpers oder eines Körperteils gemäß der Gattung der Patentansprüche, die vornehmlich zur Bekämpfung von Mammakarzinomen Verwendung findet.The invention relates to an arrangement for magnetic resonance (MR) examination and hyperthermia treatment of a body or a part of the body according to the preamble of the claims, which is used primarily for combating breast cancer.
Bekannt sind Vorrichtungen zur Ortung und Markierung von Läsionen in Gewebeschnittbildern, wobei diese Läsionen mit Antennen in verstellbaren Halterungen mit Antennen durch geeignete Kontjastmittelinjektionen in das zu untersuchende Gewebe lokalisiert werden, siehe bspw. DE 44 42 398 AI . Eine Behandlung des lädierten Gewebes ist mit dieser Vorrichtung nicht möglich. Aus der US-PS 4 323 056 ist es bekannt, in eine suspendierte Glaskeramik eingebundene magnetische Eisenoxidpartikel in Tumore zu injizieren, die zuvor lokalisiert werden müssen, und sie danach einem magnetischen Wechselfeld auszusetzen. Schließlich ist es bekannt, magnetische Substanzen in Organen, insbesondere der Leber, ohne gezielte Injektion anzureichern. Die Substanzen werden dabei intravasal injiziert, siehe C. Chambon, O. Clement, A. Le-Blanche, E. Schouman-Claeys, G. Frija: Superparamagnetic iron oxides as positive MR contrast agents: in vitro and in vivo-evidence. Magn. Res. hnaging 11 (4), 509-519 (1993); B. Hamm, T. Staks, M. Taupitz, R. Maibauer, A. Speidel, A. Huppertz, T. Frenzel, R. Lawaczek, K. J. Wolf, L. Lange: Contrast-enhanced MR imaging of liver and spieen: first experiences in humans with a new superparamagnetic iron oxide. J. Magn. Reson. Imaging 4 (5), 659-668 (1994).Devices for locating and marking lesions in tissue sectional images are known, these lesions with antennas in adjustable holders with antennas being located in the tissue to be examined by suitable injections of contaminants, see for example DE 44 42 398 AI. Treatment of the damaged tissue is not possible with this device. From US Pat. No. 4,323,056 it is known to inject magnetic iron oxide particles embedded in a suspended glass ceramic into tumors which have to be localized beforehand and then to expose them to an alternating magnetic field. Finally, it is known to accumulate magnetic substances in organs, especially the liver, without targeted injection. The substances are injected intravascularly, see C. Chambon, O. Clement, A. Le-Blanche, E. Schouman-Claeys, G. Frija: Superparamagnetic iron oxides as positive MR contrast agents: in vitro and in vivo-evidence. Magn. Res. Hnaging 11 (4), 509-519 (1993); B. Hamm, T. Staks, M. Taupitz, R. Maibauer, A. Speidel, A. Huppertz, T. Frenzel, R. Lawaczek, KJ Wolf, L. Lange: Contrast-enhanced MR imaging of liver and spieen: first experiences in humans with a new superparamagnetic iron oxide. J. Magn. Reson. Imaging 4 (5), 659-668 (1994).
Nach den bekannten Verfahren und Vorrichtungen werden MR- Untersuchungen und Hyperthermie-Behandlungen örtlich und zeitlich getrennt durchgeführt. Bekannt sind auch die Messung von Temperaturänderungen, z. B. durch HT-Eüistrahlung, mit MR-Methoden, siehe US 5 492 122 A, sowie eine feste Mammahalterung zur stereotaktischen Lokalisation von kernspintomograpliischen Befunden in der Mamma einer Patientin, siehe DE 43 25 206 AI. Eine Kontrolle des Einflusses von erhöhten Temperaturen etwa auf die Wirksamkeit lokaler Chemo- oder Magnetfeldtherapie während eines Diagnose- und Behandlungsvorganges kann bisher nicht durchgeführt werden.According to the known methods and devices, MR examinations and hyperthermia treatments are carried out separately and in time. The measurement of temperature changes, e.g. B. by HT-Eüistrahlung, with MR methods, see US 5 492 122 A, and a fixed breast holder for Stereotactic localization of MRI findings in the breast of a patient, see DE 43 25 206 AI. It has not yet been possible to control the influence of elevated temperatures, for example on the effectiveness of local chemotherapy or magnetic field therapy, during a diagnosis and treatment process.
Der Erfindung liegt daher die Aufgabe zugrunde, die Kontrolle von magnetfeldtherapeutischen und/oder chemotherapeutischen Behandlungen durch gleichzeitige oder nahezu gleichzeitige MR-Abbildung zu ermöglichen und damit zwischenzeitliche Veränderungen der Lage des Körpers oder Körperteils zu verhindern. Darüber hinaus kann zur Reduzierung von Belastungen des Körpers und zur Verringerung des Verbrauchs von Substanzen mit magnetischen Partikeln im Bedarfsfall dieselbe Substanz zur Hyperthermie und als Kontrastmittel für die MR- Untersuchung dienen.The invention is therefore based on the object of enabling control of magnetic field therapeutic and / or chemotherapeutic treatments by simultaneous or almost simultaneous MR imaging and thus preventing interim changes in the position of the body or part of the body. In addition, the same substance can be used for hyperthermia and as a contrast agent for the MR examination to reduce stress on the body and to reduce the consumption of substances with magnetic particles.
Gemäß der Erfindung wird diese Aufgabe durch die kennzeichnenden Merkmale des ersten Anspruchs gelöst. Der gemeinsame Träger ermöglicht erstmals die gleichzeitige Abbildung von Gewebeläsionen und ihre Behandlung. Durch die Vermeidung von Verschiebungen zwischen der Antenne und der Einrichtung zur Hyperthermiebehandlung werden Artefakte eliminiert. Dies ist besonders wichtig für die Auffindung, Darstellung und Behandlung kleinster Karzinome. Dabei ist es von Vorteil, wenn die Einrichtung zur Erzeugung des Wechselfeldes möglichst nahe am Köφer, also zwischen der mindestens einen, vorzugsweise ringförmigen Antenne und dem Körper angeordnet ist. Das für die Hyperthermie erforderliche elektromagnetische Wechselfeld kann primär entweder als magnetisches Feld (durch in einer geeigneten Leiteranordnung fließende Wechselströme) oder als elektrisches Feld (durch Aufladen von Elektroden) erzeugt werden. Es ist empfehlenswert, die Eifirichtung zur Erzeugung des magnetischen Wechselfeldes in Form mindestens einer Spule aus einem unmagnetischen Material, vorzugsweise Kupfer herzustellen. Vorteilhaft besteht die Spule aus Kupferrohr, das von einem Kühlmittel durchflössen wird. Für die Untersuchung von Köφerteilen ist im wesentlichen innerhalb der Spule ein vorzugsweise aus einem flexiblen, nichtleitenden Material bestehendes Haltegefaß vorgesehen, das an eine Unterdnickvorrichtung angeschlossen ist und das dazu dient, den Köφerteil während der gesamten Untersuchung und Behandlung in einer unveränderlichen Lage zu halten. Die Eiririchtung zur Erzeugung des elektrischen Wechselfeldes besteht vorzugsweise aus zwei Elektrodenplatten, die gleichzeitig als Halte- bzw. Preßmittel für den Köφer oder Köφerteil dienen können und merf r zumindest an ihren dem Köφer oder Köφerteil zugewandten Flächen mit einer isolierenden Schicht versehen sind. Der Abstand dieser Haltemittel voneinander ist zur Anpassung an den Köφerteil oder Köφer einstellbar. Eine vorteilhafte, materialsparende Ausbildung der erfϊndungsgemäßen Anordnung ergibt sich, wenn die Spule gleichzeitig als Antenne und Einrichtung zur Erzeugung des magnetischen Wechselfeldes dient. Die Spule wird dann sowohl zur MR-Untersuchung als auch der Hyper ermie-Behandlung verwendet.According to the invention, this object is achieved by the characterizing features of the first claim. For the first time, the common carrier enables simultaneous imaging of tissue lesions and their treatment. By avoiding displacements between the antenna and the device for hyperthermia treatment, artifacts are eliminated. This is particularly important for the detection, display and treatment of the smallest carcinomas. It is advantageous if the device for generating the alternating field is arranged as close as possible to the body, that is to say between the at least one, preferably annular antenna and the body. The electromagnetic alternating field required for hyperthermia can primarily be generated either as a magnetic field (by alternating currents flowing in a suitable conductor arrangement) or as an electric field (by charging electrodes). It is advisable to produce the egg direction for generating the alternating magnetic field in the form of at least one coil made of a non-magnetic material, preferably copper. The coil advantageously consists of copper tube through which a coolant flows. For the examination of body parts, a holding vessel, preferably made of a flexible, non-conductive material, is essentially inside the coil provided, which is connected to an under-thickening device and which serves to keep the body part in an unchangeable position during the entire examination and treatment. The egg direction for generating the alternating electric field preferably consists of two electrode plates, which can simultaneously serve as holding or pressing means for the body or body part and are further provided with an insulating layer at least on their surfaces facing the body or body part. The distance of these holding means from one another can be adjusted for adaptation to the body part or body. An advantageous, material-saving design of the arrangement according to the invention is obtained if the coil simultaneously serves as an antenna and device for generating the alternating magnetic field. The coil is then used for both MR examination and hyper ermia treatment.
Die Erfindung wird nachstehend an Hand der schematischen Zeichnung dreier Ausfuhrungsbeispiele näher erläutert. Es zeigen:The invention is explained below with reference to the schematic drawing of three exemplary embodiments. Show it:
Fig. 1 eine erste erfindungsgemäße Anordnung, bei der die MR- Untersuchung und Hyperthermie-Behandlung mit getrennten Mitteln durchgeführt werden,1 shows a first arrangement according to the invention, in which the MR examination and hyperthermia treatment are carried out using separate means,
Fig. 2 eine zweite erfϊndungsgemäße Anordnung, bei der die Mittel zur Hyperthermie-Behandlung als Plattenelektroden ausgebildet sind, und Fig. 3 eine dritte erfindungsgemäße Anordnung, bei der die MR- Untersuchung und die Hyperώermie-Behandlung mit derselben Spule durchgeführt werden. In allen Ausfuhrungsbeispielen wird als Köφerteil beispielhaft eine weibliche Brust verwendet.2 shows a second arrangement according to the invention, in which the means for hyperthermia treatment are designed as plate electrodes, and FIG. 3 shows a third arrangement according to the invention, in which the MR examination and the hyperemia treatment are carried out with the same coil. In all exemplary embodiments, a female breast is used as an example of the body part.
In Fig. 1 ist auf einer teilweise dargestellten Patientenliege 1 ein Träger 2 mit Flankenteilen 21, 22 für mindestens eine ringförmige Antenne 3 und mindestens eine Spule 4 angeordnet. Der Antenne 3 sind ein Verstärker 31 und eine Anzeigevorrichtung 32 zugeordnet. Die Spule 4 ist mit einem Wechselspannungsgenerator 41 verbunden, der einen Wechselstrom > 100 A mit einer Frequenz von 0,1 bis 1 MHz liefert. Sie besteht aus einem nicht magnetisierbarem Kupferrohr, in dessen Innerem ein KüMmittel 42 durch die Wirkung einer KüMmittelpumpe 43 zirkuherend fließt, die mit der Spule 4 über Kühlmittelschläuche 44 verbunden ist. Die Spule 4 ist mit einem vorzugsweise flexiblen, elektrisch und magnetisch inaktiven Gefäß 5 für eine Brust 6 ausgekleidet, die zumindest im Bereich der Flankenteile 21, 22 vollständig an der Gefaßinnenwand anliegt. Das einen Untersuchungsraum darstellende Gefäß 5 ist über einen Vakuumschlauch 51 mit einer Vakuumpumpe 52 verbunden, die einen gewünschten Unterdruck im Gefäß 5 herstellt, die Brust 6 gegen die Gefaßinnenwand und damit in eine für den anschließenden Prozeß günstige Form preßt. Für diesen Prozeß ist die Brust 6 mit einer Eisenoxidpartikel enthaltenden Substanz injiziert worden, die sich für eine beschränkte Zeit an den Stellen der lädierten Gewebeteile konzentriert. Bei Funktion der in Fig. 1 dargestellten Anordnung zur MR-Untersuchung und Hyperthermie-Behandlung wird zunächst mit Hilfe des Gefasses 5, des Vakuumschlauches 51 und der Vakuumpumpe 52 die Brust 6 in eine für die Untersuchung und Behandlung günstige, stabile Form und Lage gebracht. Anschließend wird die Spule 4 mit Hilfe des Wechselspannungsgenerators 41 erregt und damit in der Spule 4 ein Wechselfeld erzeugt, das an den Konzentrationsstellen der Substanz im Gewebe eine Hyperthermie hervorruft. Gleichzeitig wird der Kühlmittelkreislauf 42, 43 in Tätigkeit gesetzt. Wird bspw. innerhalb von 10 min das Wechselspannungsfeld angelegt, so erzeugt dieses in 10 min in den Konzentrationsstellen eine Temperatur von 43 °C, die 5 min gehalten wird. Danach wird die Behandlung beendet. Mit Hilfe der Antenne 3 und der im HF-Feld der Antenne durch die Konzentrationsstellen hervorgerufenen Veränderungen werden Signale induziert und von der Anzeigevorrichtung 32 die Lage der Läsionen (Karzinome) determiniert. Diese Lokalisierung kann während der Behandlung, also simultan, oder unmittelbar vor und/oder nach der Behandlung erfolgen, in einer Zeit also, in der die Lage und Form der Brust sich infolge der ständigen Wirksamkeit der Unterdruckanlage 51, 52 nicht ändern konnte.In FIG. 1, a carrier 2 with flank parts 21, 22 for at least one ring-shaped antenna 3 and at least one coil 4 is arranged on a patient couch 1 that is partially shown. An antenna 31 and a display device 32 are assigned to the antenna 3. The coil 4 is connected to an alternating voltage generator 41, which supplies an alternating current> 100 A with a frequency of 0.1 to 1 MHz. It consists of a non-magnetizable copper tube, inside of which a KüMmittel 42 circulates through the action of a KüMmittelpump 43, which is connected to the coil 4 via coolant hoses 44. The coil 4 is lined with a preferably flexible, electrically and magnetically inactive vessel 5 for a breast 6 which, at least in the region of the flank parts 21, 22, lies completely against the inner wall of the vessel. The vessel 5 representing an examination room is connected via a vacuum hose 51 to a vacuum pump 52 which creates a desired negative pressure in the vessel 5, presses the breast 6 against the inner wall of the vessel and thus into a shape which is favorable for the subsequent process. For this process the breast 6 has been injected with a substance containing iron oxide particles, which concentrates for a limited time at the sites of the damaged tissue parts. When the arrangement for MR examination and hyperthermia treatment shown in FIG. 1 functions, the breast 6 is first brought into a stable and favorable shape and position for the examination and treatment with the aid of the vessel 5, the vacuum hose 51 and the vacuum pump 52. Subsequently, the coil 4 is excited with the aid of the alternating voltage generator 41 and thus an alternating field is generated in the coil 4, which causes hyperthermia at the concentration points of the substance in the tissue. At the same time, the coolant circuit 42, 43 is activated. If, for example, the AC voltage field is applied within 10 minutes, it generates a temperature of 43 ° C. in the concentration points in 10 minutes, which temperature is maintained for 5 minutes. Thereafter the treatment is stopped. With the help of the antenna 3 and the changes caused by the concentration points in the RF field of the antenna, signals are induced and the position of the lesions (carcinomas) is determined by the display device 32. This localization can take place during the treatment, that is to say simultaneously, or immediately before and / or after the treatment, at a time when the position and shape of the breast could not change as a result of the constant effectiveness of the vacuum system 51, 52.
Die Brust 6 kann auch in anderer Weise, z. B. durch Kompression von außen, gepreßt werden. In Fig. 2 ist wieder eine Patientenliege 1 mit einem Träger 2 mit zwei Flankenteilen 21, 22 versehen, in denen sich eine Antenne 3 befindet und in denen zwei plattenförmige Elektroden 7, 8 mit zugehörigen Stäben 71, 81 in Richtung von Doppelpfeilen 72, 82 verstellbar angeordnet sind. Die Elektroden sind an ihren einander und einer Brust 6 zugewandten Flächen mit elektrisch isolierenden Schichten 73, 83 versehen. Zwischen den Elektrodenplatten 7, 8 befindet sich ein Untersuchungsraum 9, in den die in diesem Fall nicht mit Kontrastmittel injizierte Brust 6 während der Untersuchung und Behandlung gepreßt und in dem sie dadurch unverrückbar gehalten ist. Eine Unterdruckanlage 51, 52, wie zu Fig. 1 beschrieben, erübrigt sich in diesem Fall. Das elektrische Feld wird zur Erwärmung der gesamten Brust 6 zwischen den Elektroden 7 und 8 erzeugt. Im übrigen ist die Behandlung der Brust 6 und die Anzeige der von der Antenne 3 empfangenen Signale ähnlich wie zu Fig. 1 beschrieben. Während der Erwärmung der Brust 6 kann sie auch chemotherapeutisch behandelt werden.The breast 6 can also in other ways, for. B. by compression from the outside. 2 again shows a patient couch 1 with a carrier 2 with two flank parts 21, 22 in which there is an antenna 3 and in which two plate-shaped electrodes 7, 8 with associated rods 71, 81 in the direction of double arrows 72, 82 are arranged adjustable. The electrodes are provided on their surfaces facing one another and a breast 6 with electrically insulating layers 73, 83. Between the electrode plates 7, 8 there is an examination space 9, into which the breast 6, which in this case is not injected with contrast medium, is pressed during the examination and treatment and in which it is held immovably. A vacuum system 51, 52, as described for FIG. 1, is not necessary in this case. The electric field is generated for heating the entire breast 6 between the electrodes 7 and 8. Otherwise, the treatment of the breast 6 and the display of the signals received by the antenna 3 is similar to that described in FIG. 1. During the warming of the breast 6, it can also be treated chemotherapeutically.
In Fig. 3 ist eine Brust 6 durch Unterdruck in einem Gefäß 5 läge- und formstabil gehalten, das sich in einem Untersuchungsraum 9 zwischen zwei Flankenteilen 21, 22 befindet und von einer Spule 10 umgeben ist, die einerseits ein magnetisches Feld erzeugt und zu diesem Zweck mit einem Wechselspannungsgenerator 41, ähnlich wie zu Fig. 1 beschrieben, verbunden ist. Andererseits ist diese Spule 10 Antenne, die die von den Konzentrationsstellen in der Brust 6 ausgelösten Signale empfängt und in einem Anzeigevorrichtung 32 sichtbar werden läßt, so daß die Ermittlung der Gewebeläsien nach Ort und Größe, einschließlich ihrer Veränderungen durch die Behandlung, möglich ist. Die in Fig. 3 dargestellte erfindungsgemäße Anordnung läßt die MR-Untersuchung parallel oder seriell zur Hyperthermie-Behandlung zu; jedoch wird in diesem Fall dem seriellen Ablauf der Prozesse der Vorzug gegeben, um ihre evtl. nachteilige gegenseitige Beeinflussungen zu vermeiden. An der Eindeutigkeit der Zuordnung der Untersuchungsergebnisse zu den Behandlungsergebnissen ändert sich dabei nichts, denn die Brust 6 verändert während des Ablaufs der Prozesse ihre Lage und Form nicht. Im übrigen gilt das zu den Figuren 1 und 2 Gesagte sinngemäß. Alle in der Beschreibung, den nachfolgenden Ansprüchen und der Zeichnung dargestellten Merkmale können sowohl einzeln als auch in beliebiger Kombination miteinander erfindungswesentlich sein. In Fig. 3, a breast 6 is held in position and shape stable by vacuum in a vessel 5, which is located in an examination room 9 between two flank parts 21, 22 and is surrounded by a coil 10, which generates a magnetic field on the one hand and to this Purpose is connected to an AC voltage generator 41, similar to that described in FIG. 1. On the other hand, this coil 10 is an antenna which receives the signals triggered by the concentration points in the breast 6 and makes them visible in a display device 32, so that the determination of the tissue lesions by location and size, including their changes due to the treatment, is possible. The arrangement according to the invention shown in FIG. 3 permits the MR examination in parallel or in series with the hyperthermia treatment; however, in this case, preference is given to the serial sequence of the processes in order to avoid their possibly adverse mutual influences. Nothing changes in the unambiguity of the assignment of the examination results to the treatment results, because the breast 6 does not change its position and shape during the course of the processes. Otherwise, what has been said about FIGS. 1 and 2 applies analogously. All features shown in the description, the following claims and the drawing can be essential to the invention both individually and in any combination with one another.
BezugszeichenlisteReference list
1 Patientenliege1 patient bed
2 Träger2 carriers
3 Antenne3 antenna
4, 10 Spule4, 10 coil
5 Gefäß5 vessel
6 Brust6 chest
7, 8 Elektroden7, 8 electrodes
9 Untersuchungsraum9 examination room
21, 22 Flankenteile21, 22 flank parts
31 Verstärker31 amplifiers
32 Anzeigevorrichtung32 display device
41 Wechselspannungsgenerator41 AC voltage generator
42 Kühlmittel42 coolant
43 Kühlmittelpumpe43 coolant pump
44 Kühlmittelschläuche44 coolant hoses
51 Vakuumsehlauch51 vacuum hose
52 Vakuumpumpe52 vacuum pump
71, 81 Stäbe71, 81 bars
72, 82 Doppelpfeile72, 82 double arrows
73, 83 elektrisch isolierende Schichten 73, 83 electrically insulating layers

Claims

Patentansprüche claims
1. Anordnung zur Magnetresonanz-Untersuchung und Hyperthermie- Behandlung eines Köφers oder eines Köφerteils mit mindestens einer1. Arrangement for magnetic resonance examination and hyperthermia treatment of a body or a body part with at least one
Antenne und einer Einrichtung zur Erzeugung eines elektromagnetischen Wechselfeldes, die mindestens nahezu gleichzeitig wirksam sind, dadurch gekennzeichnet, daß die mindestens eine Antenne und die Einrichtung zur Erzeugung eines elektromagnetischen Wechselfeldes mit einem gemeinsamen Träger verbunden sind und daßAntenna and a device for generating an alternating electromagnetic field, which are effective at least almost simultaneously, characterized in that the at least one antenna and the device for generating an alternating electromagnetic field are connected to a common carrier and in that
Mittel vorgesehen sind, die den Köφer oder Köφerteil während der Untersuchung und Behandlung in einer unveränderlichen Lage bezüglich der Antenne und der Einrichtung halten.Means are provided which keep the body or body part in an invariable position with respect to the antenna and the device during the examination and treatment.
2. Anordnung gemäß Anspruch 1, dadurch gekennzeichnet, daß die Einrichtung zur Erzeugung eines elektromagnetischen Wechselfeldes zwischen der mindestens einen Antenne und dem zu untersuchenden Köφer oder Köφerteil angeordnet ist.2. Arrangement according to claim 1, characterized in that the device for generating an electromagnetic alternating field is arranged between the at least one antenna and the body to be examined or body part.
3. Anordnung gemäß Anspruch 2, dadurch gekennzeichnet, daß die Einrichtung mindestens eine Spule aus einem unmagnetischen Material ist, die ein magnetisches Wechselfeld erzeugt.3. Arrangement according to claim 2, characterized in that the device is at least one coil made of a non-magnetic material which generates an alternating magnetic field.
4. Anordnung gemäß Anspruch 3, dadurch gekennzeichnet, daß die Spule ein von einem Kühlmittel durchflossenes Kupferrohr ist.4. Arrangement according to claim 3, characterized in that the coil is a copper tube through which a coolant flows.
5. Anordnung gemäß Anspruch 2, dadurch gekennzeichnet, daß die Einrichtung aus zwei einander gegenüberstehenden Elektrodenplatten besteht, zwischen denen ein elektrisches Wechselfeld erzeugt wird.5. Arrangement according to claim 2, characterized in that the device consists of two opposing electrode plates, between which an alternating electric field is generated.
Anordnung gemäß Anspruch 5, dadurch gekennzeichnet, daß die zwei Elektrodenplatten zumindest an ihren einander zugewandten Flächen mit elektrisch isolierenden Schichten versehen sind. Arrangement according to claim 5, characterized in that the two electrode plates are provided with electrically insulating layers at least on their mutually facing surfaces.
7. Anordnung gemäß Anspruch 6, dadurch gekennzeichnet, daß die Elektrodenplatten zum Pressen des Köφers oder Köφerteils gegenläufig verstellbar angeordnet sind.7. Arrangement according to claim 6, characterized in that the electrode plates for pressing the body or body part are arranged adjustable in opposite directions.
8. Anordnung gemäß Anspruch 3, dadurch gekennzeichnet, daß in der Spule ein elektrisch und magnetisch unwirksames Gefäß zur Aumahme des Köφers oder Köφerteils angeordnet ist.8. Arrangement according to claim 3, characterized in that an electrically and magnetically ineffective vessel is arranged in the coil for taking the body or body part.
9. Anordnung gemäß Anspruch 8, dadurch gekennzeichnet, daß das Gefäß mit einer Einrichtung zur Erzeugung eines Unterdruckes im9. Arrangement according to claim 8, characterized in that the vessel with a device for generating a vacuum in
Gefäß verbunden ist.Vessel is connected.
10. Anordnung gemäß Anspruch 2, dadurch gekennzeichnet, daß nur eine Spule vorgesehen ist, die gleichzeitig als Antenne und als Einrichtung zur Erzeugung eines elektromagnetischen Wechselfeldes dient. 10. The arrangement according to claim 2, characterized in that only one coil is provided, which simultaneously serves as an antenna and as a device for generating an electromagnetic alternating field.
PCT/EP1998/001073 1997-02-25 1998-02-25 Device for magnetic resonance imagery and for treating hypothermia WO1998037928A1 (en)

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