WO1999002214A1 - Interbody device and method for treatment of osteoporotic vertebral collapse - Google Patents
Interbody device and method for treatment of osteoporotic vertebral collapse Download PDFInfo
- Publication number
- WO1999002214A1 WO1999002214A1 PCT/US1998/014146 US9814146W WO9902214A1 WO 1999002214 A1 WO1999002214 A1 WO 1999002214A1 US 9814146 W US9814146 W US 9814146W WO 9902214 A1 WO9902214 A1 WO 9902214A1
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- vertebral
- vertebral bodies
- catheter
- introducer
- expandable membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7097—Stabilisers comprising fluid filler in an implant, e.g. balloon; devices for inserting or filling such implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8808—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it with sealing collar for bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8811—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by the introducer tip, i.e. the part inserted into or onto the bone
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- A—HUMAN NECESSITIES
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8816—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections
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- A—HUMAN NECESSITIES
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8819—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by the introducer proximal part, e.g. cannula handle, or by parts which are inserted inside each other, e.g. stylet and cannula
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
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- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/885—Tools for expanding or compacting bones or discs or cavities therein
- A61B17/8852—Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc
- A61B17/8858—Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc laterally or radially expansible
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4601—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
- A61F2002/30583—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid filled with hardenable fluid, e.g. curable in-situ
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
- A61F2002/30586—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid having two or more inflatable pockets or chambers
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- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0085—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof hardenable in situ, e.g. epoxy resins
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- A61M25/00—Catheters; Hollow probes
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- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1093—Balloon catheters with special features or adapted for special applications having particular tip characteristics
Definitions
- the present disclosure relates to an apparatus and method for treating a structural collapse of the human vertebrae, and more particularly, to an intervertebral
- Osteopenia is a bone condition resulting in a reduction in the normal content of the mineral calcium within a bone.
- Osteoporosis the pathological weakening of bone by severe demineralization, is brought about by advanced osteopenia and gives rise to significantly higher incidences of bone fractures.
- Osteopenia or osteoporosis in the spine can result in fracture collapse of one or more vertebrae or bone segments thereby shortening and deforming the spine. In some cases, these deformities inhibit a person's ability to function normally and may also affect a person's ability to breathe normally due to the collapse of the vertebral segments.
- Osteoporotic fractures are a common health problem and generally occur principally at the wrists, hip joints, ribs and collar bones.
- collapses involving the vertebrae while the most common, are the least understood of the various fractures.
- the collapsing vertebra Upon collapse of a spinal vertebra, the collapsing vertebra is transformed into the shape of a wedge having the narrow portion directed towards an anterior direction (front), thus causing the spine to exhibit the classic forward bending and the formation of a posterior hump.
- the collapse is usually opposite and away from the posterior compartment or spinal canal housing the spinal cord.
- a lesser occurring collapse of the posterior compartment of a spinal vertebra may result in a
- the vertebral collapse causes a loss of the contained vertebral bone marrow and an associated loss of vertebral body height. Due to a difference in construction and metabolism, the outer hard cortical enclosure of the vertebral bone does not suffer as much loss of mineral or strength as the softer interior cancellous bone.
- the most important risk factors for bone fractures are an individual's: (1) age, (2) genetic factors, (3) environmental factors, (4) hormone levels, (5) presence of
- vertebral collapse fractures are a significant clinical and economic problem.
- the best treatment for osteoporosis is prevention particularly since the loss of
- bone strength that accompanies bone loss is not known to be reversible. Identification of those at risk by measurement of risk factors may help target prevention efforts.
- treatable risk factors include: peptic ulcer, tuberculosis and illnesses or conditions that may cause dizziness, weakness and falling. These factors are particularly important in the elderly. It is clear that appropriate diet, exercise and supportive treatments are helpful in nearly all cases. However, a very large number of cases are not preventable since they are strongly influenced by genetic, medical or environmental circumstances. In such cases, certain new drugs including oral alendronate, an aminobisphosphonate or bisphosphonated etidronate taken daily, can progressively increase the bone mass (strength) in the body, including the spine and hip areas. Such treatments can reduce the incidence of vertebral fractures, the progression of vertebral fracture deformities and height loss in postmenopausal
- osteoporotic women Unfortunately, these drugs have no beneficial effect to reverse the collapse after it has occurred. In fact, regardless of the predisposing factors, once the collapse has occurred, pain control and immobilization are essentially the only current treatments available. There exists no present method that can acutely reverse the collapse, lead to reconstitution of the vertebra and relieve the severe associated pain.
- the current mode of treatments include bed rest, the wearing of a rigid brace, sedatives, muscle relaxers, physical therapy modalities and other palliative measures. These treatments exhibit some value in pain reduction but generally the fractured or collapsed vertebra must be stabilized or fused for the severe pain to effectively
- the injected material may leak through the fractured or collapsed portions of the vertebra and enter the adjacent major vessels, possibly causing an immediate and potentially lethal blockage.
- these materials and other self-curing thermoplastics are highly viscous and cannot be injected through a reasonably sized hypodermic tube, cannula, catheter or introducer. The use of these materials also generate significant heat which may damage the sensitive bone cells leading to bone atrophy and delayed integration.
- the above-mentioned polymerics do not form or integrate into new bone and as such may create a new problem where the bone and the plastic material have a zone of non-union or pseudoarthrosis.
- the techniques described herein may also be used in certain cases of complete or partial vertebral body collapse from erosion of the bone by a metastatic cancer or the like.
- the present disclosure is directed to an intervertebral apparatus and method for treating collapsed vertebrae due to osteoporotic weakening and collapse of vertebrae.
- the interbody device and method for treatment of osteoporotic vertebral collapse is specifically designed to re-establish or reform the lost vertebrae height attributable to
- an apparatus for repairing a collapsed space within vertebral bodies includes an introducer including an elongate member having proximal and distal ends and defining a longitudinal bore.
- the introducer further includes a projection along an external length thereof, the projection facilitating the rotation of the threaded portion into the vertebral bodies.
- the elongate member includes a threaded portion adjacent the distal end and being configured for insertion into vertebral bodies to facilitate mounting of the elongate member to the vertebral bodies and a catheter at least partially positionable within the longitudinal bore of the elongate member of the introducer.
- the threaded portion of the elongate member further includes a collar, the collar having an elastic seal adapted to form a seal along an external portion of the vertebral bodies.
- the catheter includes a catheter body member having proximal and distal ends, an inflation lumen extending along at least a portion of the catheter body and an expandable membrane adjacent the distal end of the catheter body member in fluid
- the expandable membrane is extendible beyond the distal end of the introducer and positionable between the vertebral bodies.
- the expandable membrane is expandable in response to inflation fluids conveyed by the inflation lumen to exert a force on the vertebral bodies to achieve a desired spacing therewithin.
- the apparatus includes a source of inflation fluid in communication with the inflation lumen to expand the expandable membrane.
- the source of inflation fluid includes an injected bone growth inducing material.
- the apparatus also includes a treating agent delivery lumen extending along at least a portion of the catheter body and in fluid communication with an interior of the vertebral bodies.
- An injection device is coupled to at least one of the inflation lumen and treating agent delivery lumen for providing the inflation fluids to the expandable membrane and to the treating agent delivery lumen for providing bone growth inducing materials within the interior of the vertebral bodies.
- the injection device is preferably a high injection pressure syringe.
- the expandable membrane is releasably attached to the catheter body member.
- An uncoupling sleeve is mounted about the elongate member of the introducer, wherein the uncoupling sleeve is movable to separate the expandable membrane from the catheter body member.
- a method for reforming a collapsed vertebra is also disclosed. The method
- the expanding step includes inflating the expandable member with inflation fluids.
- the catheter body includes a delivery lumen terminating in an opening in the catheter body member and wherein the step of
- injecting includes introducing the treating agent into the delivery lumen to be conveyed thereby and dispensed through the opening.
- the method further includes the step of injecting a treating agent into the collapsed area of the vertebral body portions to facilitate bone growth within
- Fig. 1 is a schematic view of the interbody device according to the present disclosure illustrating a guide needle and associated introducer
- FIG. 2 is a view illustrating a cross-sectional diagrammatic view of a typical vertebra of the spine
- FIG. 3 is a cross-sectional view of the introducer along lines 3-3 of FIG. 2;
- FIG. 4 is an oblique isometric view illustrating a hand-held, three-ring pressure syringe according to the present disclosure
- FIG. 5 is a lateral isometric view illustrating a partially collapsed vertebra prior to reforming.
- FIG. 5A is lateral isomeric view illustrating a reformed vertebra utilizing the interbody device according to the present disclosure.
- the disclosure is applicable to a wide variety of procedures including, but, not limited to joint repair, non-union fractures, spinal stabilization and the like.
- the present method and instrumentation finds application in both open and mimmally invasive procedures including endoscopic and arthroscopic procedures wherein access to the surgical site is achieved through a cannula or small incision.
- proximal will refer to the portion of the structure which is closer to the operator, while the term “distal” will refer to the portion which is further from the operator.
- distal will refer to the portion which is further from the operator.
- the following discussion includes a description of the interbody vertebral device followed by a description of the preferred method for treatment of osteoporotic vertebral collapse in accordance with the present disclosure.
- FIG. 1 is a cross-sectional representation of a collapsed vertebral spinal segment 10 with guide needle 12 engaged within its collapsed interior 11.
- the percutaneous insertion of each guide needle 12 is preferably performed under the visual aide of a continuous fluoroscopic contrast agent to ensure the proper alignment of guide needles 12 within vertebral interior 11.
- a first and second guide needle 12 (not shown) is placed from each side of the back or chest into the collapsed vertebra 10 along an insertion path through a narrow access between the costovertebral junctions.
- auger tip 22 and sealing member 24 is inserted over each needle 12 and subsequently screwed into the vertebral body 10.
- each introducer 20 includes butterfly shaped thumbscrew projections 28 for manually twisting the auger-like threaded tip 22 into the outer shell of the vertebral body 10.
- Each auger threaded tip 22 includes double start threads 23 having a high pitch so as to facilitate the initial biting into and penetration through the tough outer cortex of the vertebra 10.
- the auger threaded tip 22 facilitates in positioning, fixating or mounting introducer 20 to the vertebral body 10.
- a sealing member 24 which includes a small collar 24a and an elastic seal 24b adjacent the collar.
- the collar 24a acts as a stop against the vertebral body 10 while the elastic seal 24b assists in preventing the escape of marrow and injected materials from leaking out through the bore created by the introducer 20.
- the interbody device according to the present disclosure can be manufactured in various sizes appropriate for the safe insertion of the needles 12 and introducers 20 through the lateral structures of vertebral bodies of various dimensions.
- each catheter 30 includes a first lumen 32 and a second lumen 34 located in each introducer 20.
- At a distal end of catheter 30 is attached at least one balloon or cuff 14 preferably manufactured of a thin, flexible, high-pressure polymeric material as is known in the art. Once inflated, the balloons 14 are dimensioned to conform to the pre-collapse interior dimensions of the particular vertebra being
- the two balloons 14 are positioned bilaterally into the central marrow area of vertebral space 11 of the collapsed vertebra 10.
- the fluoroscopic contrast agent may be injected through the lumens
- the balloons 14 are preferably manufactured to withstand high pressures (up to 10 atmospheres) and retain a volume of up to 10 ml., although balloons meeting other pressures and volumes are contemplated.
- the balloon attachment to catheter 30 and associated lumens 32 and 34 is separable by an uncoupling member or device to permit the balloons 14 to be permanently left within the vertebral space 11.
- an uncoupling member includes a sleeve 26 (FIG. 3) which is slidably mounted over catheter 30 and movable in a distal direction to slide the balloon 14 off the distal end of the catheter 30.
- balloon 14 would be self-sealing, whereby upon removal, the proximal end of the balloon 14 attached to the catheter 30 would close or seal.
- the uncoupling sleeves 26 are especially beneficial when the balloons 14 are filled with a hardening material, as will be discussed below.
- the balloon membranes may be manufactured from a biodegradable material so as to permit time controlled dissolving of the balloons 14 to thereby expose the hardening materials contained therein to the interior
- biodegradable balloon membranes may be manufactured from known materials such as a polylactic acid polymer, a polygalactone biodegradable film, a hydrogel membrane such as polyvinyl acetate or an acrylonitrile.
- the balloons 14 can be fabricated where only selected segments of the balloon's membrane would slowly dissolve when exposed to body fluids. This feature initially maintains the internal balloon pressure but allows the contained injected material to slowly integrate into the recipient bone of vertebra 10.
- a single hand operated syringe 40 is shown although, as will be discussed below, as many as four syringes 40 may be used to inject materials through lumens 32 and 34 of catheter 30.
- the syringes 40 of the present disclosure are preferably used to hydraulically inflate balloons 14 and to inject medicants within vertebral space 11, although other similar injection/inflation devices such as pumps, squeezable membranes or the like may be used.
- Each lumen 32 and 34 engages a separate syringe 40 which acts to inflate balloon 14 and inject medicants within vertebral space 11, respectively.
- Syringes 40 are preferably three- ring pressure syringes having finger rings 46 on a collar 48 and a thumb ring 47 on plunger portion 49.
- the syringes 40 may be filled with a combination of injectable materials and/or solutions including sterile saline solution, fluoroscopic contrast agent, bone growth inducing materials, hardening materials and the like.
- the injectable materials may be a slurry of calcium complex known to integrate into bone with a supporting polymeric filler to improve strength until the fracture has healed or fused.
- a bone growth factor such as bone morphogenic protein may be added to the injectate to facilitate the rapid growth of firm bone within vertebra 10.
- each balloon 14 is inflated separately with a particular solution or combination thereof dependent upon the anatomical conditions of the collapsed vertebrae 10.
- the syringes 40 are connected to catheter 30 and lumens 32 and 34 via high-pressure flexible polymeric tubing 42.
- the tubing 42 is attached to each lumen 32 and 34 and respective syringes 40 with Luer connections 44.
- Valves structures 45 are placed in-line along Luer connections 44, tubing 42 or syringes 40 to maintain the inflation pressure in each balloon 14 once inflated.
- Syringes 40 are capable of manually providing high amounts of injection pressure (8 or 10 atmospheres) to balloons 14.
- the syringe solution inflates balloons 14, as well as, cause each balloon 14 to internally dissect or collapse the cancellous matrix of the vertebral marrow within vertebral space 11 thereby creating a cavity within the vertebral body 10.
- the inflation of balloons 14 create a cavity within vertebral body 10 and cause the hardened end plates 52 of vertebra 10 to separate and expand to a point 50 restoring the normal pre-collapse vertebral height of vertebra 10.
- the dimensions of the balloons 14 are such that, upon inflation, the balloons 14 are maintained within the confines of the vertebral space 11.
- the method utilizes a controlled and monitored technique which is simple to perform and provides relative safe effective treatment for the patient.
- the method is performed percutaneously as opposed to open surgery.
- the procedure is performed under aseptic conditions in the operating room or in a standard cardiac catheterization room in the X-ray department.
- the patient is partly anesthetized and sedated using appropriate intravenous medications.
- the patient is suspended in a chest and underarm supporting harness to overcome forces such as gravity and muscle spasms in the thoracic and lumbar spinal segments. These forces participate in the collapsing force imparted on the vertebrae and must be overcome to facilitate the re-expansion of the collapsed vertebral bodies.
- the points of entry and trajectory to the target vertebrae are noted and marked on the overlying skin. Attention to the patient's anatomical detail is necessary to avoid potential serious damage to structures normally found adjacent to the vertebrae, such as, segmental blood vessels and spinal nerves, as well as, avoiding penetration of the lungs and other
- TM OMNIPAQUE
- TM HYPAQUE
- introducers 20 are passed over the needles at the insertion points of the vertebra 10. With the aid of the auger-like threaded tips 22 of introducers 20, each introducer 20 is screwed into the cortical or lateral wall 54 of the collapsed vertebral body 10 using thumbscrew wings 28 positioned proximally on the introducers 20. The guide needles 12 are then removed.
- Catheter 30 includes at least one balloon 14 distally situated and coupled to a first 32 or second 34 lumen which is introduced within each catheter 30.
- One lumen 32 may be used to inflate balloon 14 while a second lumen 34 may be provided for the injection of materials such as contrast agent or bone fixation materials into the surrounding vertebral space 11.
- both balloons 14 are hydraulically inflated using a solution of sterile saline and fluoroscopic contrast agent.
- this pressure inflates balloons 14 and correspondingly expands vertebral space 11. As this pressure increases, the expanding balloons 14 create a cavity within the central soft bone area of vertebral space 11. As the balloons 14 are further inflated, the pressure resistant end plates 52 of vertebra 10 are pushed apart
- a first balloon 14 is then deflated leaving a cavity.
- rapidly hardening materials such as bone growth inducing materials are injected through lumen 34 of catheter 30 with the use of, e.g., a syringe 40 discussed above.
- These hardening materials may be a calcium based self-curing material combined with bone
- either or all of the balloons 14 fabricated from an absorbable material may be filled with the rapid hardening, bone growth inducing material and left permanently within the vertebral space 11, as discussed hereinabove. Due to the
- a first balloon 14 is deflated and removed.
- the second balloon 14 is then deflated and its cavity is likewise injected with bone growth inducing substance or the like.
- the introducers 20 with auger-like tips 22 are then unscrewed and removed from the body.
- the patient will preferably remain in the traction rigging, or wear a rigid supporting brace for a matter of several minutes or hours as the setting process proceeds to completion. A brace might be required for a matter of weeks in some
- the number and size of balloons 14 inflated within the vertebral space 11 may vary dependent upon the specific ailment, dimensions, and anatomical variants of the diseased vertebrae.
- the number of lumens 32, 34 within introducer 20 and corresponding materials transported therein may vary to accommodate delivery of solutions, bone growth inducing substances, anesthetic, contrast agent (fluoroscopic solution) and any combination thereof to the
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002328229A CA2328229C (en) | 1997-07-09 | 1998-07-09 | Interbody device and method for treatment of osteoporotic vertebral collapse |
US09/807,318 US6852095B1 (en) | 1997-07-09 | 1998-07-09 | Interbody device and method for treatment of osteoporotic vertebral collapse |
AU83867/98A AU8386798A (en) | 1997-07-09 | 1998-07-09 | Interbody device and method for treatment of osteoporotic vertebral collapse |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5284997P | 1997-07-09 | 1997-07-09 | |
US60/052,849 | 1997-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999002214A1 true WO1999002214A1 (en) | 1999-01-21 |
Family
ID=21980301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/014146 WO1999002214A1 (en) | 1997-07-09 | 1998-07-09 | Interbody device and method for treatment of osteoporotic vertebral collapse |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU8386798A (en) |
CA (1) | CA2328229C (en) |
WO (1) | WO1999002214A1 (en) |
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CA2328229C (en) | 2007-04-17 |
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