WO1999004631A1 - Disinfecting, detergent and descaling product for medical equipment - Google Patents
Disinfecting, detergent and descaling product for medical equipment Download PDFInfo
- Publication number
- WO1999004631A1 WO1999004631A1 PCT/FR1998/001633 FR9801633W WO9904631A1 WO 1999004631 A1 WO1999004631 A1 WO 1999004631A1 FR 9801633 W FR9801633 W FR 9801633W WO 9904631 A1 WO9904631 A1 WO 9904631A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aqueous solution
- product
- benzalkonium chloride
- descaling
- lactic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
Definitions
- the subject of the invention is a disinfection, detergency and descaling product for medical equipment.
- It relates more particularly but without limitation to disinfection, detergency and descaling of hemodialysis generators as well as related water treatment circuits and in particular circuits by reverse osmosis.
- Hemodialysis machines and their water treatment circuits must be periodically disinfected in order to avoid any microbial development, such as bacteria, spores or others, which may subsequently affect the dialysis patient.
- the antiseptic agents used must have a sufficiently broad spectrum to inhibit any development of bacteria in this type of material.
- this is generally carried out using acetic acid or citric acid.
- an anti-microbial composition comprising an organic acid in proportions of between 50 and 99.9% by weight and a quaternary ammonium in proportions of between 0.1 and 50% has been proposed in document WO 98/03066. in weight.
- This composition has the drawback, due to the high concentration of organic acid, of leading to a final product that is too foaming and difficult to formulate.
- the object of the invention is therefore to propose a product which is both disinfectant, detergent and descaler for medical equipment without however generating a phenomenon of toxicity vis-à-vis the patient or staff, or lead to corrosion of the material.
- the invention provides a disinfection, detergency and descaling product for medical equipment, characterized in that it consists of an aqueous solution comprising:
- lactic acid has a synergistic effect on the detergent and disinfectant properties of benzalkonium chloride.
- quaternary ammoniums make it possible to take off the biofilm present on the walls of the material.
- lactic acid makes it possible to increase the activity of benzalkonium chloride, in particular on Pseudomonas aeruginosa by a factor of 10 compared to benzalkonium chloride alone.
- the invention consists in having selected on the one hand benzalkonium chloride as disinfecting and detergency agent and on the other hand, lactic acid as descaling agent, which considerably increases the bactericidal effect of benzalkonium chloride vis-à-vis in particular Pseudomonas aeruginosa.
- the concentration of benzalkonium chloride is between 10 and 50 grams per liter.
- the concentration of lactic acid is between 1 and 5 percent of the final aqueous solution.
- concentration of lactic acid is between 1 and 5 percent of the final aqueous solution.
- an excessively foaming product is obtained which is difficult to formulate and then to use.
- the product is not effective.
- the concentration of benzalkonium chloride is between 20 and 30 grams per liter of final aqueous solution.
- the concentration of lactic acid is between 2 and 3 percent of the final aqueous solution.
- the product of the invention comprises a complexing agent ensuring the sequestration of bivalent ions liable to appear.
- this complexing agent is ethylene diamine tetraacetic acid (EDTA).
- a solution is prepared containing: benzalkonium chloride 22 grams lactic acid 30 milliliters demineralized water sufficient quantity for one liter
- the three components are mixed at a temperature of around 23 ° C.
- a ready-to-use product is obtained, intended in particular for disinfecting and descaling hemodialysis generators and their water treatment circuit.
- the bactericidal activity of a 2.5% benzalkonium chloride solution in water was evaluated against the following bacteria: Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus faecium and by the method known as " membrane filtration method described by standard AFNOR 72151
- N Control count (incorporation)
- N ' Control count (membrane filtration)
- n Count in the tests (neutralization of the bactericidal effect of the product)
- X count final test
- N ' Control count (membrane filtration)
- n Test count (neutralization of the bactericidal effect of the product)
- X final test count
- the product of the invention has bactericidal activity on the
- Pseudomonas aeruginosa at a concentration of 0.10% by volume for a contact time of 5 minutes, that is to say an activity ten times greater than that of benzalkonium chloride used alone.
- the same renewed activity is also observed with respect to Escherichia coli and Enterococcus Faecium.
- the invention therefore has many advantages.
- lactic acid increases considerably the bactericidal activity of benzalkonium chloride, in particular on Pseudomonas aeruginosa.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- External Artificial Organs (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98939728A EP0998197A1 (en) | 1997-07-24 | 1998-07-23 | Disinfecting, detergent and descaling product for medical equipment |
AU88140/98A AU8814098A (en) | 1997-07-24 | 1998-07-23 | Disinfecting, detergent and descaling product for medical equipment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9709665A FR2766371B1 (en) | 1997-07-24 | 1997-07-24 | DISINFECTION, DETERGENCE AND DESCALING PRODUCT FOR MEDICAL EQUIPMENT |
FR97/09665 | 1997-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999004631A1 true WO1999004631A1 (en) | 1999-02-04 |
Family
ID=9509782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1998/001633 WO1999004631A1 (en) | 1997-07-24 | 1998-07-23 | Disinfecting, detergent and descaling product for medical equipment |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0998197A1 (en) |
AU (1) | AU8814098A (en) |
FR (1) | FR2766371B1 (en) |
WO (1) | WO1999004631A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9293511B2 (en) | 1998-07-08 | 2016-03-22 | E Ink Corporation | Methods for achieving improved color in microencapsulated electrophoretic devices |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2723303A1 (en) * | 1977-05-24 | 1978-11-30 | Bayer Ag | Disinfectant contg. phenolic cpd. and hydroxy-carboxylic acid - for controlling microbes in paint, dyes, water etc. |
AT382310B (en) * | 1985-09-30 | 1987-02-10 | Horst Felsch | Method for decalcifying, disinfecting and cleaning mouth rinse devices, etc |
GB2187097A (en) * | 1986-02-28 | 1987-09-03 | Unilever Plc | Disinfectant compositions |
EP0265202A2 (en) * | 1986-10-20 | 1988-04-27 | Unilever Plc | Disinfectant compositions |
EP0320786A1 (en) * | 1987-12-17 | 1989-06-21 | Dr. Wolman GmbH | Wood-protecting agent |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4137544C2 (en) * | 1991-11-12 | 1998-07-30 | Kramer Axel | Antimicrobial combination of active ingredients based on oxygen-releasing compounds |
FI103704B (en) * | 1996-07-19 | 1999-08-31 | Kemira Chemicals Oy | Antimicrobial composition, method of preparation and use thereof |
-
1997
- 1997-07-24 FR FR9709665A patent/FR2766371B1/en not_active Expired - Fee Related
-
1998
- 1998-07-23 AU AU88140/98A patent/AU8814098A/en not_active Abandoned
- 1998-07-23 WO PCT/FR1998/001633 patent/WO1999004631A1/en not_active Application Discontinuation
- 1998-07-23 EP EP98939728A patent/EP0998197A1/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2723303A1 (en) * | 1977-05-24 | 1978-11-30 | Bayer Ag | Disinfectant contg. phenolic cpd. and hydroxy-carboxylic acid - for controlling microbes in paint, dyes, water etc. |
AT382310B (en) * | 1985-09-30 | 1987-02-10 | Horst Felsch | Method for decalcifying, disinfecting and cleaning mouth rinse devices, etc |
GB2187097A (en) * | 1986-02-28 | 1987-09-03 | Unilever Plc | Disinfectant compositions |
EP0265202A2 (en) * | 1986-10-20 | 1988-04-27 | Unilever Plc | Disinfectant compositions |
EP0320786A1 (en) * | 1987-12-17 | 1989-06-21 | Dr. Wolman GmbH | Wood-protecting agent |
Non-Patent Citations (2)
Title |
---|
CHEMICAL ABSTRACTS, vol. 115, no. 7, 1991, Columbus, Ohio, US; abstract no. 70185f * |
DATABASE WPI Section Ch Week 9123, Derwent World Patents Index; Class A97, AN 91-166591, XP002061751 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9293511B2 (en) | 1998-07-08 | 2016-03-22 | E Ink Corporation | Methods for achieving improved color in microencapsulated electrophoretic devices |
Also Published As
Publication number | Publication date |
---|---|
FR2766371A1 (en) | 1999-01-29 |
EP0998197A1 (en) | 2000-05-10 |
AU8814098A (en) | 1999-02-16 |
FR2766371B1 (en) | 2000-04-14 |
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