WO1999036553A3 - Regulation of biological events using multimeric chimeric proteins - Google Patents
Regulation of biological events using multimeric chimeric proteins Download PDFInfo
- Publication number
- WO1999036553A3 WO1999036553A3 PCT/US1999/000178 US9900178W WO9936553A3 WO 1999036553 A3 WO1999036553 A3 WO 1999036553A3 US 9900178 W US9900178 W US 9900178W WO 9936553 A3 WO9936553 A3 WO 9936553A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- regulation
- biological events
- chimeric proteins
- multimeric chimeric
- multimeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000540254A JP2002508971A (en) | 1998-01-15 | 1999-01-15 | Regulation of biological events using multimeric chimeric proteins |
EP99902059A EP1045915A2 (en) | 1998-01-15 | 1999-01-15 | Regulation of biological events using multimeric chimeric proteins |
CA002318402A CA2318402A1 (en) | 1998-01-15 | 1999-01-15 | Regulation of biological events using multimeric chimeric proteins |
AU22132/99A AU755784B2 (en) | 1998-01-15 | 1999-01-15 | Regulation of biological events using multimeric chimeric proteins |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7159198P | 1998-01-15 | 1998-01-15 | |
US60/071,591 | 1998-01-15 | ||
US7201698P | 1998-01-21 | 1998-01-21 | |
US60/072,016 | 1998-01-21 | ||
US7221998P | 1998-01-22 | 1998-01-22 | |
US09/012,097 | 1998-01-22 | ||
US60/072,219 | 1998-01-22 | ||
US09/012,097 US6187757B1 (en) | 1995-06-07 | 1998-01-22 | Regulation of biological events using novel compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999036553A2 WO1999036553A2 (en) | 1999-07-22 |
WO1999036553A3 true WO1999036553A3 (en) | 1999-10-21 |
Family
ID=27486136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/000178 WO1999036553A2 (en) | 1998-01-15 | 1999-01-15 | Regulation of biological events using multimeric chimeric proteins |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1045915A2 (en) |
JP (1) | JP2002508971A (en) |
AU (1) | AU755784B2 (en) |
CA (1) | CA2318402A1 (en) |
WO (1) | WO1999036553A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8426167B2 (en) | 2001-06-22 | 2013-04-23 | Roche Diagnostics Operations, Inc. | Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
EP2022856B1 (en) | 1994-08-20 | 2011-09-14 | Gendaq Limited | Improvements in or relating to binding proteins for recognition of DNA |
US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
US5830696A (en) | 1996-12-05 | 1998-11-03 | Diversa Corporation | Directed evolution of thermophilic enzymes |
US6562594B1 (en) | 1999-09-29 | 2003-05-13 | Diversa Corporation | Saturation mutagenesis in directed evolution |
US6939689B2 (en) | 1995-12-07 | 2005-09-06 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
US6361974B1 (en) | 1995-12-07 | 2002-03-26 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
US6238884B1 (en) | 1995-12-07 | 2001-05-29 | Diversa Corporation | End selection in directed evolution |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US6713279B1 (en) | 1995-12-07 | 2004-03-30 | Diversa Corporation | Non-stochastic generation of genetic vaccines and enzymes |
US7018793B1 (en) | 1995-12-07 | 2006-03-28 | Diversa Corporation | Combinatorial screening of mixed populations of organisms |
US6352842B1 (en) | 1995-12-07 | 2002-03-05 | Diversa Corporation | Exonucease-mediated gene assembly in directed evolution |
US6358709B1 (en) | 1995-12-07 | 2002-03-19 | Diversa Corporation | End selection in directed evolution |
US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
ATE466952T1 (en) | 1998-03-02 | 2010-05-15 | Massachusetts Inst Technology | POLY ZINC FINGER PROTEINS WITH IMPROVED LINKERS |
AU751487B2 (en) | 1998-03-17 | 2002-08-15 | Gendaq Limited | Nucleic acid binding proteins |
US7013219B2 (en) | 1999-01-12 | 2006-03-14 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US7070934B2 (en) | 1999-01-12 | 2006-07-04 | Sangamo Biosciences, Inc. | Ligand-controlled regulation of endogenous gene expression |
US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
US20030104526A1 (en) | 1999-03-24 | 2003-06-05 | Qiang Liu | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
ATE264863T1 (en) * | 1999-08-24 | 2004-05-15 | Ariad Gene Therapeutics Inc | 28-EPIRAPALOGUE |
DE60023936T2 (en) | 1999-12-06 | 2006-05-24 | Sangamo Biosciences Inc., Richmond | METHODS OF USING RANDOMIZED ZINCFINGER PROTEIN LIBRARIES FOR IDENTIFYING GENERAL FUNCTIONS |
AU2001226935B2 (en) | 2000-01-24 | 2006-06-22 | Gendaq Limited | Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules |
US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
AU2884102A (en) | 2000-12-07 | 2002-06-18 | Sangamo Biosciences Inc | Regulation of angiogenesis with zinc finger proteins |
DK1353941T3 (en) | 2001-01-22 | 2013-06-17 | Sangamo Biosciences Inc | Modified zinc finger binding proteins |
US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
IL162734A0 (en) | 2002-02-01 | 2005-11-20 | Ariad Gene Therapeutics Inc | Phosphorus-containing compounds & uses thereof |
US7361635B2 (en) | 2002-08-29 | 2008-04-22 | Sangamo Biosciences, Inc. | Simultaneous modulation of multiple genes |
US20080287675A1 (en) * | 2007-05-18 | 2008-11-20 | Abbott Laboratories | Cascade system |
SG10201908848RA (en) | 2010-03-29 | 2019-10-30 | Univ Pennsylvania | Pharmacologically induced transgene ablation system |
US9315825B2 (en) | 2010-03-29 | 2016-04-19 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
US20140031418A1 (en) | 2011-04-20 | 2014-01-30 | The Trustees Of The University Of Pennsylvania | Regimens and Compositions for AAV-Mediated Passive Immunization of Airborne Pathogens |
CN110423282B (en) | 2013-02-15 | 2023-09-08 | 加利福尼亚大学董事会 | Chimeric antigen receptor and methods of use thereof |
US9719106B2 (en) | 2013-04-29 | 2017-08-01 | The Trustees Of The University Of Pennsylvania | Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof |
CA2956667A1 (en) * | 2013-07-29 | 2015-02-05 | Bluebird Bio, Inc. | Multipartite signaling proteins and uses thereof |
CA2985081A1 (en) | 2015-05-13 | 2016-12-15 | The Trustees Of The University Of Pennsylvania | Aav-mediated expression of anti-influenza antibodies and methods of use thereof |
WO2016196655A1 (en) | 2015-06-03 | 2016-12-08 | The Regents Of The University Of California | Cas9 variants and methods of use thereof |
WO2017075335A1 (en) | 2015-10-28 | 2017-05-04 | Voyager Therapeutics, Inc. | Regulatable expression using adeno-associated virus (aav) |
EP3377523A4 (en) | 2015-11-19 | 2019-06-19 | The Regents of The University of California | Conditionally repressible immune cell receptors and methods of use thereof |
CA3007473A1 (en) * | 2015-12-14 | 2017-06-22 | Bellicum Pharmaceuticals, Inc. | Dual controls for therapeutic cell activation or elimination |
WO2020047527A2 (en) | 2018-09-02 | 2020-03-05 | F1 Bioventures, Llc | Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs |
WO2018161064A1 (en) | 2017-03-03 | 2018-09-07 | F1 Oncology, Inc. | Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof |
CA3019426A1 (en) | 2016-04-15 | 2017-10-19 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
WO2018111834A1 (en) | 2016-12-13 | 2018-06-21 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of exogenous drug activation of chemical-induced signaling complexes expressed in engineered cells in vitro and in vivo |
JOP20190200A1 (en) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | Compositions useful in treatment of spinal muscular atrophy |
JP2020510430A (en) | 2017-02-28 | 2020-04-09 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Influenza vaccine based on AAV vector |
FI3589730T3 (en) | 2017-02-28 | 2024-02-22 | Univ Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
AR112834A1 (en) | 2017-09-26 | 2019-12-18 | Novartis Ag | RAPAMYCIN DERIVATIVES |
MX2020003888A (en) | 2017-10-18 | 2020-11-06 | Regenxbio Inc | Fully-human post-translationally modified antibody therapeutics. |
EP3697449A1 (en) | 2017-10-18 | 2020-08-26 | REGENXBIO Inc. | Treatment of ocular diseases and metastatic colon cancer with human post-translationally modified vegf-trap |
CN111565737A (en) | 2017-12-14 | 2020-08-21 | 蓝鸟生物公司 | DARIC interleukin receptor |
WO2019212990A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
CN112368289B (en) | 2018-05-01 | 2024-02-20 | 锐新医药公司 | C26-linked rapamycin analogues as MTOR inhibitors |
CN113286608A (en) | 2018-10-05 | 2021-08-20 | 圣安娜儿童癌症研究中心 | Chimeric Antigen Receptor (CAR) groups |
CN113164576A (en) | 2018-10-05 | 2021-07-23 | 圣安娜儿童癌症研究中心 | Chimeric Antigen Receptor (CAR) groups |
EP3632460A1 (en) | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
EP3632461A1 (en) | 2018-10-05 | 2020-04-08 | St. Anna Kinderkrebsforschung | A group of chimeric antigen receptors (cars) |
CN113966236A (en) | 2019-04-03 | 2022-01-21 | 再生生物股份有限公司 | Gene therapy for ocular conditions |
EP3959323A1 (en) | 2019-04-24 | 2022-03-02 | REGENXBIO Inc. | Fully-human post-translationally modified antibody therapeutics |
MX2022002366A (en) | 2019-08-26 | 2022-07-19 | Regenxbio Inc | Treatment of diabetic retinopathy with fully-human post-translationally modified anti-vegf fab. |
MX2022004146A (en) | 2019-10-07 | 2022-09-19 | Regenxbio Inc | Adeno-associated virus vector pharmaceutical composition and methods. |
AU2020397938A1 (en) * | 2019-12-05 | 2022-06-23 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
WO2022060916A1 (en) | 2020-09-15 | 2022-03-24 | Regenxbio Inc. | Vectorized antibodies for anti-viral therapy |
EP4213890A1 (en) | 2020-09-15 | 2023-07-26 | RegenxBio Inc. | Vectorized lanadelumab and administration thereof |
WO2022076582A1 (en) | 2020-10-07 | 2022-04-14 | Regenxbio Inc. | Gene therapy for ocular manifestations of cln2 disease |
EP4236999A1 (en) | 2020-10-28 | 2023-09-06 | RegenxBio Inc. | Vectorized anti-tnf-alfa antibodies for ocular indications |
WO2022094157A1 (en) | 2020-10-28 | 2022-05-05 | Regenxbio Inc. | Vectorized anti-cgrp and anti-cgrpr antibodies and administration thereof |
WO2022094255A2 (en) | 2020-10-29 | 2022-05-05 | Regenxbio Inc. | Vectorized factor xii antibodies and administration thereof |
MX2023004843A (en) | 2020-10-29 | 2023-05-10 | Regenxbio Inc | Vectorized tnf-alpha antagonists for ocular indications. |
CN116670152A (en) | 2020-12-01 | 2023-08-29 | 宾夕法尼亚州大学信托人 | Novel compositions having tissue-specific targeting motifs and compositions containing the same |
WO2022187289A1 (en) | 2021-03-01 | 2022-09-09 | Exuma Biotech Corp. | Methods and compositions for the delivery of retroviral particles |
BR112023021971A2 (en) | 2021-04-23 | 2024-02-20 | Univ Pennsylvania | COMPOSITIONS WITH BRAIN-SPECIFIC DIRECTION MOTIFS AND COMPOSITIONS CONTAINING THE SAME |
TW202325845A (en) | 2021-10-02 | 2023-07-01 | 賓州大學委員會 | Novel aav capsids and compositions containing same |
WO2023147304A1 (en) | 2022-01-25 | 2023-08-03 | The Trustees Of The University Of Pennsylvania | Aav capsids for improved heart transduction and detargeting of liver |
WO2023168305A1 (en) | 2022-03-01 | 2023-09-07 | Exuma Biotech Corp. | Viral particles with membrane-bound hyaluronidase |
WO2023201308A1 (en) | 2022-04-14 | 2023-10-19 | Regenxbio Inc. | Gene therapy for treating an ocular disease |
WO2023205610A2 (en) | 2022-04-18 | 2023-10-26 | Regenxbio Inc. | Hybrid aav capsids |
WO2023215807A1 (en) | 2022-05-03 | 2023-11-09 | Regenxbio Inc. | VECTORIZED ANTI-TNF-α INHIBITORS FOR OCULAR INDICATIONS |
TW202400803A (en) | 2022-05-03 | 2024-01-01 | 美商銳進科斯生物股份有限公司 | Vectorized anti-complement antibodies and complement agents and administration thereof |
WO2024073669A1 (en) | 2022-09-30 | 2024-04-04 | Regenxbio Inc. | Treatment of ocular diseases with recombinant viral vectors encoding anti-vegf fab |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
WO1996041865A1 (en) * | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Rapamcycin-based regulation of biological events |
-
1999
- 1999-01-15 JP JP2000540254A patent/JP2002508971A/en active Pending
- 1999-01-15 EP EP99902059A patent/EP1045915A2/en not_active Withdrawn
- 1999-01-15 WO PCT/US1999/000178 patent/WO1999036553A2/en not_active Application Discontinuation
- 1999-01-15 AU AU22132/99A patent/AU755784B2/en not_active Expired
- 1999-01-15 CA CA002318402A patent/CA2318402A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
WO1996041865A1 (en) * | 1995-06-07 | 1996-12-27 | Ariad Gene Therapeutics, Inc. | Rapamcycin-based regulation of biological events |
Non-Patent Citations (2)
Title |
---|
JUAN I LUENGO ET AL.: "Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domainand positioned at the FKBP12-FRAP interface", CURRENT BIOLOGY, vol. 2, 1995, pages 471 - 481, XP002045681 * |
VICTOR M. RIVERA ET AL.: "A humanized system for phamacologic control of gene expression", NATURE MEDICINE, vol. 2, no. 9, September 1996 (1996-09-01), pages 1028 - 1032, XP002018162 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8426167B2 (en) | 2001-06-22 | 2013-04-23 | Roche Diagnostics Operations, Inc. | Methods for producing fusion polypeptides or enhancing expression of fusion polypeptides |
Also Published As
Publication number | Publication date |
---|---|
AU755784B2 (en) | 2002-12-19 |
AU2213299A (en) | 1999-08-02 |
CA2318402A1 (en) | 1999-07-22 |
JP2002508971A (en) | 2002-03-26 |
WO1999036553A2 (en) | 1999-07-22 |
EP1045915A2 (en) | 2000-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1999036553A3 (en) | Regulation of biological events using multimeric chimeric proteins | |
IL206293A0 (en) | Genetically engineered duckweed | |
CA2383926A1 (en) | Functional genomics using zinc finger proteins | |
WO2002059277A3 (en) | Electroactive materials for stimulation of biological activity of stem cells | |
AU560340B2 (en) | Rennin from recombinant dna | |
AU2002250670A1 (en) | Improved culture vessel having non-flat surfaces for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same | |
AU2002235994A1 (en) | Method for producing proteins by fermentation of microorganisms from the thermus family, the protein mixture thus obtained and cosmetic compositions containing same | |
AU3462899A (en) | Sequence and method for genetic engineering of proteins with cell membrane translocating activity | |
EP1005529A4 (en) | Methods for lyophilizing competent cells | |
WO2003016511A1 (en) | Method of extended culture for antigen-specific cytotoxic t lumphocytes | |
WO2004044183A3 (en) | Feeding processes for fermentation | |
WO2000029551A3 (en) | Cells, culture methods, and their use in autologous transplantation therapy | |
WO2000004051A3 (en) | Growth differentiation factor promoter and uses therefor | |
WO2002002591A3 (en) | Peptides for use in culture media | |
GB9901499D0 (en) | Biological control | |
EP1728859A4 (en) | Sequence capable of accelerating gene expression at moderately low temperature | |
EP2281892A3 (en) | Methods for producing polypeptides in respiratory-deficient Trichoderma cells | |
AU2001278700A1 (en) | Method of culturing human chondrocytes | |
AU2787400A (en) | Compositions and methods for modulating growth or differentiation of growth-factor dependent cells | |
WO2000006713A3 (en) | Methods for recombinant protein production in mammalian cells comprising co-expression with fetuin | |
HK1052029A1 (en) | Method for increasing the yield of recombinant proteins in microbial fermentation processes. | |
CA2375549A1 (en) | Delivery system for biological material | |
WO2001040443A3 (en) | Method for producing adherent animal cells | |
WO2004096991A3 (en) | Bcl2l12 polypeptide activators and inhibitors | |
AU2003245850A1 (en) | Culture systems for the sterile continuous cultivation of cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
ENP | Entry into the national phase |
Ref document number: 2318402 Country of ref document: CA Ref country code: CA Ref document number: 2318402 Kind code of ref document: A Format of ref document f/p: F |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2000 540254 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 22132/99 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1999902059 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09600241 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1999902059 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 22132/99 Country of ref document: AU |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1999902059 Country of ref document: EP |