WO2000001850A3 - Molecular torches - Google Patents

Molecular torches Download PDF

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Publication number
WO2000001850A3
WO2000001850A3 PCT/US1999/015098 US9915098W WO0001850A3 WO 2000001850 A3 WO2000001850 A3 WO 2000001850A3 US 9915098 W US9915098 W US 9915098W WO 0001850 A3 WO0001850 A3 WO 0001850A3
Authority
WO
WIPO (PCT)
Prior art keywords
target
molecular torches
binding domain
joining region
domain
Prior art date
Application number
PCT/US1999/015098
Other languages
French (fr)
Other versions
WO2000001850A2 (en
Inventor
Michael M Becker
Gary Schroth
Original Assignee
Gen Probe Inc
Michael M Becker
Gary Schroth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc, Michael M Becker, Gary Schroth filed Critical Gen Probe Inc
Priority to AU48575/99A priority Critical patent/AU762728B2/en
Priority to EP99932220A priority patent/EP1092047B1/en
Priority to CA2333253A priority patent/CA2333253C/en
Priority to AT99932220T priority patent/ATE440963T1/en
Priority to JP2000558240A priority patent/JP4646404B2/en
Priority to DE69941333T priority patent/DE69941333D1/en
Publication of WO2000001850A2 publication Critical patent/WO2000001850A2/en
Publication of WO2000001850A3 publication Critical patent/WO2000001850A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

The present invention features 'molecular torches' and the use of molecular torches for detecting the presence of a target nucleic acid sequence. Molecular torches contain a target binding domain, a target closing domain, and a joining region. The target binding domain is biased towards the target sequence such that the target binding domain forms a more stable hybrid with the target sequence than with the target closing domain under the same hybridization conditions. The joining region facilitates the formation or maintenance of a closed torch.
PCT/US1999/015098 1998-07-02 1999-07-01 Molecular torches WO2000001850A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU48575/99A AU762728B2 (en) 1998-07-02 1999-07-01 Molecular torches
EP99932220A EP1092047B1 (en) 1998-07-02 1999-07-01 Molecular torches
CA2333253A CA2333253C (en) 1998-07-02 1999-07-01 Molecular torches
AT99932220T ATE440963T1 (en) 1998-07-02 1999-07-01 MOLECULAR TORCHES
JP2000558240A JP4646404B2 (en) 1998-07-02 1999-07-01 Molecular torch
DE69941333T DE69941333D1 (en) 1998-07-02 1999-07-01 MOLECULAR TORCHES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9161698P 1998-07-02 1998-07-02
US60/091,616 1998-07-02

Publications (2)

Publication Number Publication Date
WO2000001850A2 WO2000001850A2 (en) 2000-01-13
WO2000001850A3 true WO2000001850A3 (en) 2000-04-06

Family

ID=22228747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015098 WO2000001850A2 (en) 1998-07-02 1999-07-01 Molecular torches

Country Status (9)

Country Link
US (6) US6361945B1 (en)
EP (1) EP1092047B1 (en)
JP (2) JP4646404B2 (en)
AT (1) ATE440963T1 (en)
AU (1) AU762728B2 (en)
CA (1) CA2333253C (en)
DE (1) DE69941333D1 (en)
ES (1) ES2330812T3 (en)
WO (1) WO2000001850A2 (en)

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