WO2000069449A3 - Conditioned cell culture medium compositions and methods of use - Google Patents

Conditioned cell culture medium compositions and methods of use Download PDF

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Publication number
WO2000069449A3
WO2000069449A3 PCT/US2000/013016 US0013016W WO0069449A3 WO 2000069449 A3 WO2000069449 A3 WO 2000069449A3 US 0013016 W US0013016 W US 0013016W WO 0069449 A3 WO0069449 A3 WO 0069449A3
Authority
WO
WIPO (PCT)
Prior art keywords
medium
conditioned
cells
stem cells
methods
Prior art date
Application number
PCT/US2000/013016
Other languages
French (fr)
Other versions
WO2000069449A2 (en
Inventor
Gail K Naughton
David L Horwitz
Mark A Applegate
Joan Zeltinger
Jonathan N Mansbridge
Andreas Kern
Lee K Landeen
Anthony Ratcliffe
R Emmett Pinney
Original Assignee
Advanced Tissue Sciences Inc
Gail K Naughton
David L Horwitz
Mark A Applegate
Joan Zeltinger
Jonathan N Mansbridge
Andreas Kern
Lee K Landeen
Anthony Ratcliffe
R Emmett Pinney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23216124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000069449(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU48430/00A priority Critical patent/AU772829C/en
Priority to CA2373302A priority patent/CA2373302C/en
Priority to NZ515476A priority patent/NZ515476A/en
Priority to BR0010568-6A priority patent/BR0010568A/en
Priority to US09/979,813 priority patent/US7118746B1/en
Priority to AT00930643T priority patent/ATE311894T1/en
Priority to EP00930643A priority patent/EP1178812B1/en
Priority to MXPA01011487A priority patent/MXPA01011487A/en
Priority to JP2000617908A priority patent/JP5138129B2/en
Priority to DE60024612T priority patent/DE60024612T2/en
Application filed by Advanced Tissue Sciences Inc, Gail K Naughton, David L Horwitz, Mark A Applegate, Joan Zeltinger, Jonathan N Mansbridge, Andreas Kern, Lee K Landeen, Anthony Ratcliffe, R Emmett Pinney filed Critical Advanced Tissue Sciences Inc
Publication of WO2000069449A2 publication Critical patent/WO2000069449A2/en
Publication of WO2000069449A3 publication Critical patent/WO2000069449A3/en
Priority to US11/538,380 priority patent/US8361485B2/en
Priority to US12/349,451 priority patent/US8138147B2/en
Priority to US13/417,017 priority patent/US8476231B2/en
Priority to US13/842,243 priority patent/US20130210076A1/en
Priority to US13/841,342 priority patent/US20130203169A1/en
Priority to US13/842,129 priority patent/US9458486B2/en
Priority to US13/842,324 priority patent/US20130217129A1/en
Priority to US13/841,466 priority patent/US20130210725A1/en
Priority to US13/841,139 priority patent/US20130217069A1/en
Priority to US15/284,223 priority patent/US20170055561A1/en

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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Abstract

Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
PCT/US2000/013016 1999-05-14 2000-05-12 Conditioned cell culture medium compositions and methods of use WO2000069449A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
AT00930643T ATE311894T1 (en) 1999-05-14 2000-05-12 METHOD FOR PREPARING CONDITIONED CELL CULTURE MEDIA COMPOSITIONS
MXPA01011487A MXPA01011487A (en) 1999-05-14 2000-05-12 Conditioned cell culture medium compositions and methods of use.
NZ515476A NZ515476A (en) 1999-05-14 2000-05-12 Conditioned cell culture medium compositions and methods of use
BR0010568-6A BR0010568A (en) 1999-05-14 2000-05-12 Pharmaceutical composition, three-dimensional stromal tissue, food substance, nutritional supplement, methods for manufacturing a pharmaceutical composition, for improved wound or burn healing, for making a cosmetic composition, for correcting a cosmetic defect, for inhibiting or reversing deleterious effects on cells in a person, to stimulate hair growth, and to isolate collagen
US09/979,813 US7118746B1 (en) 1999-05-14 2000-05-12 Conditioned cell culture medium compositions and methods of use
AU48430/00A AU772829C (en) 1999-05-14 2000-05-12 Conditioned cell culture medium compositions and methods of use
EP00930643A EP1178812B1 (en) 1999-05-14 2000-05-12 Methods of making conditioned cell culture medium compositions
CA2373302A CA2373302C (en) 1999-05-14 2000-05-12 Conditioned cell culture medium compositions and methods of use
JP2000617908A JP5138129B2 (en) 1999-05-14 2000-05-12 Cell culture conditioned medium composition and method of use
DE60024612T DE60024612T2 (en) 1999-05-14 2000-05-12 METHOD FOR PRODUCING CONDITIONED CELL CULTURE MEDIUM COMPOSITIONS
US11/538,380 US8361485B2 (en) 1999-05-14 2006-10-03 Conditioned cell culture medium compositions and methods of use
US12/349,451 US8138147B2 (en) 1999-05-14 2009-01-06 Conditioned cell culture medium compositions and methods of use
US13/417,017 US8476231B2 (en) 1999-05-14 2012-03-09 Conditioned cell culture medium compositions and methods of use
US13/841,139 US20130217069A1 (en) 1999-05-14 2013-03-15 Conditioned cell culture medium compositions and methods of use
US13/841,466 US20130210725A1 (en) 1999-05-14 2013-03-15 Conditioned cell culture medium compositions and methods of use
US13/842,243 US20130210076A1 (en) 1999-05-14 2013-03-15 Conditioned cell culture medium compositions and methods of use
US13/841,342 US20130203169A1 (en) 1999-05-14 2013-03-15 Conditioned cell culture medium compositions and methods of use
US13/842,129 US9458486B2 (en) 1999-05-14 2013-03-15 Conditioned cell culture medium compositions and methods of use
US13/842,324 US20130217129A1 (en) 1999-05-14 2013-03-15 Conditioned cell culture medium compositions and methods of use
US15/284,223 US20170055561A1 (en) 1999-05-14 2016-10-03 Conditioned cell culture medium compositions and methods of use

Applications Claiming Priority (2)

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US09/313,538 1999-05-14
US09/313,538 US6372494B1 (en) 1999-05-14 1999-05-14 Methods of making conditioned cell culture medium compositions

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US11/538,380 Division US8361485B2 (en) 1999-05-14 2006-10-03 Conditioned cell culture medium compositions and methods of use

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JP (2) JP5138129B2 (en)
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AT (1) ATE311894T1 (en)
AU (1) AU772829C (en)
BR (1) BR0010568A (en)
CA (1) CA2373302C (en)
DE (1) DE60024612T2 (en)
ES (1) ES2254176T3 (en)
HU (1) HUP0201887A2 (en)
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