WO2000072870A1 - Compositions of a-beta peptide and processes for producing same - Google Patents
Compositions of a-beta peptide and processes for producing same Download PDFInfo
- Publication number
- WO2000072870A1 WO2000072870A1 PCT/US2000/015302 US0015302W WO0072870A1 WO 2000072870 A1 WO2000072870 A1 WO 2000072870A1 US 0015302 W US0015302 W US 0015302W WO 0072870 A1 WO0072870 A1 WO 0072870A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptide
- composition
- pharmaceutically acceptable
- solution
- suspension
- Prior art date
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Marine Sciences & Fisheries (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL14657500A IL146575A0 (en) | 1999-06-01 | 2000-06-01 | Compositions of a-beta peptide and processes for producing same |
NZ515744A NZ515744A (en) | 1999-06-01 | 2000-06-01 | Aqueous solutions comprising high concentrations of amyloid-beta peptide prepared by adjusting the pH of the solution to one effective to solubilise the peptide |
BR0011251-8A BR0011251A (en) | 1999-06-01 | 2000-06-01 | A-beta peptide compositions and processes for producing them |
EP00942668A EP1181040A1 (en) | 1999-06-01 | 2000-06-01 | Compositions of a-beta peptide and processes for producing same |
SK1701-2001A SK17012001A3 (en) | 1999-06-01 | 2000-06-01 | A composition comprising an aqueous solution, lyophilized composition of a-beta peptide, process for the preparation of sterile composition, method of preventing and treating, method of inducing an antibody response and the use |
KR1020017015474A KR20020016813A (en) | 1999-06-01 | 2000-06-01 | Compositions of a-beta peptide and processes for producing same |
EEP200100649A EE200100649A (en) | 1999-06-01 | 2000-06-01 | A-beta peptide compositions and methods for their preparation |
MXPA01012355A MXPA01012355A (en) | 1999-06-01 | 2000-06-01 | Compositions of a-beta peptide and processes for producing same. |
AU57261/00A AU5726100A (en) | 1999-06-01 | 2000-06-01 | Compositions of a-beta peptide and processes for producing same |
CA002374897A CA2374897A1 (en) | 1999-06-01 | 2000-06-01 | Compositions of a-beta peptide and processes for producing same |
JP2001511317A JP2003519620A (en) | 1999-06-01 | 2000-06-01 | A-beta peptide composition and method for producing the same |
IS6182A IS6182A (en) | 1999-06-01 | 2001-11-29 | A-beta peptide and process to create them |
NO20015859A NO20015859L (en) | 1999-06-01 | 2001-11-30 | A- <beta> peptide preparations and methods for their preparation |
HR20010901A HRP20010901A2 (en) | 1999-06-01 | 2001-12-04 | Compositions of a-beta peptide and processes for producing same |
BG106249A BG106249A (en) | 1999-06-01 | 2001-12-20 | Composition of a-beta peptide and process for producing same |
HK02106241.2A HK1045938A1 (en) | 1999-06-01 | 2002-08-23 | Compositions of a-beta peptide and processes for producing same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13704799P | 1999-06-01 | 1999-06-01 | |
US60/137,047 | 1999-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000072870A1 true WO2000072870A1 (en) | 2000-12-07 |
Family
ID=22475602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/015302 WO2000072870A1 (en) | 1999-06-01 | 2000-06-01 | Compositions of a-beta peptide and processes for producing same |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1181040A1 (en) |
JP (1) | JP2003519620A (en) |
KR (1) | KR20020016813A (en) |
CN (1) | CN1353615A (en) |
AR (1) | AR024558A1 (en) |
AU (1) | AU5726100A (en) |
BG (1) | BG106249A (en) |
BR (1) | BR0011251A (en) |
CA (1) | CA2374897A1 (en) |
CZ (1) | CZ20014150A3 (en) |
EE (1) | EE200100649A (en) |
HK (1) | HK1045938A1 (en) |
HR (1) | HRP20010901A2 (en) |
IL (1) | IL146575A0 (en) |
IS (1) | IS6182A (en) |
MX (1) | MXPA01012355A (en) |
NO (1) | NO20015859L (en) |
NZ (1) | NZ515744A (en) |
PE (1) | PE20010212A1 (en) |
PL (1) | PL352575A1 (en) |
RU (1) | RU2001135800A (en) |
SK (1) | SK17012001A3 (en) |
TR (1) | TR200103476T2 (en) |
WO (1) | WO2000072870A1 (en) |
ZA (1) | ZA200109704B (en) |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002025279A2 (en) * | 2000-09-19 | 2002-03-28 | Evotec Neurosciences Gmbh | Use of amyloid precursor protein for treating brain amyloidosis |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US6787140B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
US6808712B2 (en) | 1997-12-02 | 2004-10-26 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7700719B2 (en) | 2000-07-07 | 2010-04-20 | Bioarctic Neuroscience Ab | Arctic β amyloid protofibril |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7871615B2 (en) | 2003-05-30 | 2011-01-18 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7893214B2 (en) | 1997-12-02 | 2011-02-22 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US7977316B2 (en) | 1999-06-01 | 2011-07-12 | Elan Pharmaceuticals, Inc. | Prevention and treatment of amyloidogenic diseases |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
US8025878B2 (en) | 2006-03-23 | 2011-09-27 | Bioarctic Neuroscience Ab | Protofibril selective antibodies and the use thereof |
US8106164B2 (en) | 2004-06-21 | 2012-01-31 | Bioarctic Neuroscience Ab | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US8105594B2 (en) | 1998-05-21 | 2012-01-31 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US8128928B2 (en) | 2002-03-12 | 2012-03-06 | Wyeth Llc | Humanized antibodies that recognize beta amyloid peptide |
WO2013020723A1 (en) | 2011-08-05 | 2013-02-14 | Glaxosmithkline Biologicals S.A. | Compositions and uses thereof for the treatment or prevention of alzheimer's disease |
US8613920B2 (en) | 2007-07-27 | 2013-12-24 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8871212B2 (en) | 2001-08-20 | 2014-10-28 | H. Lundbeck A/S | Amyloid-beta polypeptide vaccine |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US9573994B2 (en) | 2014-07-10 | 2017-02-21 | Bioarctic Neuroscience Ab | Aβ protofibril binding antibodies |
US9644025B2 (en) | 2007-10-17 | 2017-05-09 | Wyeth Llc | Immunotherapy regimes dependent on ApoE status |
US10208109B2 (en) | 2005-11-30 | 2019-02-19 | Abbvie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
CN114957438A (en) * | 2022-06-28 | 2022-08-30 | 亿彤科技发展(福建)有限公司 | Human Abeta 1-42 antigenic determinant polypeptide for detecting Alzheimer disease and preparation method thereof |
Citations (2)
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WO1991016819A1 (en) * | 1990-04-27 | 1991-11-14 | Molecular Rx., Inc. | Method and composition for treatment of central nervous systems disease states associated with abnormal amyloid beta protein |
WO1999027944A1 (en) * | 1997-12-02 | 1999-06-10 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
-
2000
- 2000-05-31 AR ARP000102690A patent/AR024558A1/en unknown
- 2000-05-31 PE PE2000000521A patent/PE20010212A1/en not_active Application Discontinuation
- 2000-06-01 CA CA002374897A patent/CA2374897A1/en not_active Abandoned
- 2000-06-01 MX MXPA01012355A patent/MXPA01012355A/en unknown
- 2000-06-01 NZ NZ515744A patent/NZ515744A/en unknown
- 2000-06-01 RU RU2001135800/14A patent/RU2001135800A/en unknown
- 2000-06-01 CZ CZ20014150A patent/CZ20014150A3/en unknown
- 2000-06-01 JP JP2001511317A patent/JP2003519620A/en not_active Withdrawn
- 2000-06-01 CN CN00808374A patent/CN1353615A/en active Pending
- 2000-06-01 IL IL14657500A patent/IL146575A0/en unknown
- 2000-06-01 AU AU57261/00A patent/AU5726100A/en not_active Abandoned
- 2000-06-01 BR BR0011251-8A patent/BR0011251A/en not_active Application Discontinuation
- 2000-06-01 EP EP00942668A patent/EP1181040A1/en not_active Withdrawn
- 2000-06-01 EE EEP200100649A patent/EE200100649A/en unknown
- 2000-06-01 WO PCT/US2000/015302 patent/WO2000072870A1/en not_active Application Discontinuation
- 2000-06-01 TR TR2001/03476T patent/TR200103476T2/en unknown
- 2000-06-01 KR KR1020017015474A patent/KR20020016813A/en not_active Application Discontinuation
- 2000-06-01 SK SK1701-2001A patent/SK17012001A3/en unknown
- 2000-06-01 PL PL00352575A patent/PL352575A1/en not_active Application Discontinuation
-
2001
- 2001-11-26 ZA ZA200109704A patent/ZA200109704B/en unknown
- 2001-11-29 IS IS6182A patent/IS6182A/en unknown
- 2001-11-30 NO NO20015859A patent/NO20015859L/en not_active Application Discontinuation
- 2001-12-04 HR HR20010901A patent/HRP20010901A2/en not_active Application Discontinuation
- 2001-12-20 BG BG106249A patent/BG106249A/en unknown
-
2002
- 2002-08-23 HK HK02106241.2A patent/HK1045938A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991016819A1 (en) * | 1990-04-27 | 1991-11-14 | Molecular Rx., Inc. | Method and composition for treatment of central nervous systems disease states associated with abnormal amyloid beta protein |
WO1999027944A1 (en) * | 1997-12-02 | 1999-06-10 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
Cited By (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6787138B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US8034348B2 (en) | 1997-12-02 | 2011-10-11 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US8642044B2 (en) | 1997-12-02 | 2014-02-04 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US6787140B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6787139B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US8034339B2 (en) | 1997-12-02 | 2011-10-11 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US9051363B2 (en) | 1997-12-02 | 2015-06-09 | Janssen Sciences Ireland Uc | Humanized antibodies that recognize beta amyloid peptide |
US6787143B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6808712B2 (en) | 1997-12-02 | 2004-10-26 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6818218B2 (en) | 1997-12-02 | 2004-11-16 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US8535673B2 (en) | 1997-12-02 | 2013-09-17 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US7893214B2 (en) | 1997-12-02 | 2011-02-22 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6787144B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US8105594B2 (en) | 1998-05-21 | 2012-01-31 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
US7977316B2 (en) | 1999-06-01 | 2011-07-12 | Elan Pharmaceuticals, Inc. | Prevention and treatment of amyloidogenic diseases |
US8124081B2 (en) | 1999-06-01 | 2012-02-28 | Crimagua Limited | Prevention and treatment of amyloidogenic diseases |
US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US7700719B2 (en) | 2000-07-07 | 2010-04-20 | Bioarctic Neuroscience Ab | Arctic β amyloid protofibril |
US8409575B2 (en) | 2000-07-07 | 2013-04-02 | Bioarctic Neuroscience Ab | Antibodies specific for amyloid beta protofibril |
WO2002025279A2 (en) * | 2000-09-19 | 2002-03-28 | Evotec Neurosciences Gmbh | Use of amyloid precursor protein for treating brain amyloidosis |
WO2002025279A3 (en) * | 2000-09-19 | 2002-07-04 | Evotec Neurosciences Gmbh | Use of amyloid precursor protein for treating brain amyloidosis |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
US8871212B2 (en) | 2001-08-20 | 2014-10-28 | H. Lundbeck A/S | Amyloid-beta polypeptide vaccine |
US8128928B2 (en) | 2002-03-12 | 2012-03-06 | Wyeth Llc | Humanized antibodies that recognize beta amyloid peptide |
US10464976B2 (en) | 2003-01-31 | 2019-11-05 | AbbVie Deutschland GmbH & Co. KG | Amyloid β(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US7871615B2 (en) | 2003-05-30 | 2011-01-18 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US8404459B2 (en) | 2004-06-21 | 2013-03-26 | Bioarctic Neuroscience Ab | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US8106164B2 (en) | 2004-06-21 | 2012-01-31 | Bioarctic Neuroscience Ab | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US8999936B2 (en) | 2004-06-21 | 2015-04-07 | Bioarctic Neuroscience Ab | Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof |
US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
US9540432B2 (en) | 2005-11-30 | 2017-01-10 | AbbVie Deutschland GmbH & Co. KG | Anti-Aβ globulomer 7C6 antibodies |
US10538581B2 (en) | 2005-11-30 | 2020-01-21 | Abbvie Inc. | Anti-Aβ globulomer 4D10 antibodies |
US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
US10208109B2 (en) | 2005-11-30 | 2019-02-19 | Abbvie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
US10323084B2 (en) | 2005-11-30 | 2019-06-18 | Abbvie Inc. | Monoclonal antibodies against amyloid beta protein and uses thereof |
US9034334B2 (en) | 2006-03-23 | 2015-05-19 | Bioarctic Neuroscience Ab | Protofibril selective antibodies and the use thereof |
US8025878B2 (en) | 2006-03-23 | 2011-09-27 | Bioarctic Neuroscience Ab | Protofibril selective antibodies and the use thereof |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US9951125B2 (en) | 2006-11-30 | 2018-04-24 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US9359430B2 (en) | 2006-11-30 | 2016-06-07 | Abbvie Inc. | Abeta conformer selective anti-Abeta globulomer monoclonal antibodies |
US9394360B2 (en) | 2006-11-30 | 2016-07-19 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
US8613920B2 (en) | 2007-07-27 | 2013-12-24 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US9644025B2 (en) | 2007-10-17 | 2017-05-09 | Wyeth Llc | Immunotherapy regimes dependent on ApoE status |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9822171B2 (en) | 2010-04-15 | 2017-11-21 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US10047121B2 (en) | 2010-08-14 | 2018-08-14 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9062101B2 (en) | 2010-08-14 | 2015-06-23 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
WO2013020724A1 (en) | 2011-08-05 | 2013-02-14 | Glaxosmithkline Biologicals S.A. | Composition comprising a tlr agonist and an antibody specific for an antigen and uses thereof as vaccine |
WO2013020723A1 (en) | 2011-08-05 | 2013-02-14 | Glaxosmithkline Biologicals S.A. | Compositions and uses thereof for the treatment or prevention of alzheimer's disease |
US9573994B2 (en) | 2014-07-10 | 2017-02-21 | Bioarctic Neuroscience Ab | Aβ protofibril binding antibodies |
CN114957438A (en) * | 2022-06-28 | 2022-08-30 | 亿彤科技发展(福建)有限公司 | Human Abeta 1-42 antigenic determinant polypeptide for detecting Alzheimer disease and preparation method thereof |
CN114957438B (en) * | 2022-06-28 | 2024-04-02 | 福建亿彤生物科技有限公司 | Human Abeta 1-42 epitope polypeptide for detecting Alzheimer disease and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
PL352575A1 (en) | 2003-08-25 |
HRP20010901A2 (en) | 2003-04-30 |
IL146575A0 (en) | 2002-07-25 |
ZA200109704B (en) | 2003-02-26 |
AR024558A1 (en) | 2002-10-16 |
HK1045938A1 (en) | 2002-12-20 |
RU2001135800A (en) | 2003-08-20 |
EE200100649A (en) | 2003-02-17 |
PE20010212A1 (en) | 2001-02-22 |
NO20015859D0 (en) | 2001-11-30 |
JP2003519620A (en) | 2003-06-24 |
KR20020016813A (en) | 2002-03-06 |
SK17012001A3 (en) | 2002-06-04 |
NZ515744A (en) | 2004-04-30 |
BG106249A (en) | 2002-08-30 |
IS6182A (en) | 2001-11-29 |
MXPA01012355A (en) | 2003-06-24 |
CA2374897A1 (en) | 2000-12-07 |
NO20015859L (en) | 2002-02-01 |
CZ20014150A3 (en) | 2002-05-15 |
CN1353615A (en) | 2002-06-12 |
EP1181040A1 (en) | 2002-02-27 |
TR200103476T2 (en) | 2002-04-22 |
AU5726100A (en) | 2000-12-18 |
BR0011251A (en) | 2002-03-05 |
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