WO2001000783A3 - Monitorable three-dimensional scaffolds and tissue culture systems - Google Patents

Monitorable three-dimensional scaffolds and tissue culture systems Download PDF

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Publication number
WO2001000783A3
WO2001000783A3 PCT/US2000/017542 US0017542W WO0100783A3 WO 2001000783 A3 WO2001000783 A3 WO 2001000783A3 US 0017542 W US0017542 W US 0017542W WO 0100783 A3 WO0100783 A3 WO 0100783A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimensional
tissue
biocompatible
stromal
stromal cells
Prior art date
Application number
PCT/US2000/017542
Other languages
French (fr)
Other versions
WO2001000783A2 (en
Inventor
Gail K Naughton
Jonathan N Mansbridge
David L Horwitz
Joan Zeltinger
David J Cerny
Original Assignee
Advanced Tissue Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Tissue Sciences Inc filed Critical Advanced Tissue Sciences Inc
Priority to AU57679/00A priority Critical patent/AU5767900A/en
Publication of WO2001000783A2 publication Critical patent/WO2001000783A2/en
Publication of WO2001000783A3 publication Critical patent/WO2001000783A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

The present invention relates to three-dimensional scaffolds and three-dimensional stromal tissues comprising at least one biocompatible biosensor and methods of preparation and use thereof. In a preferred embodiment, the three-dimensional tissue is a living stromal tissue prepared in vitro, comprising stromal cells and connective tissue proteins naturally secreted by the stromal cells attached to and substantially enveloping a framework composed of a biocompatible, non-living material formed into a three-dimensional structure having interstitial spaces bridged by the stromal cells in operational association with a biocompatible chemical sensor. The biosensor may be used to monitor tissue growth, viability and integrity in vitro or in vivo or may be used to enhance or improve tissue function after implantation into a patient.
PCT/US2000/017542 1999-06-25 2000-06-26 Monitorable three-dimensional scaffolds and tissue culture systems WO2001000783A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU57679/00A AU5767900A (en) 1999-06-25 2000-06-26 Monitorable three-dimensional scaffolds and tissue culture systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14102999P 1999-06-25 1999-06-25
US60/141,029 1999-06-25

Publications (2)

Publication Number Publication Date
WO2001000783A2 WO2001000783A2 (en) 2001-01-04
WO2001000783A3 true WO2001000783A3 (en) 2001-05-17

Family

ID=22493847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017542 WO2001000783A2 (en) 1999-06-25 2000-06-26 Monitorable three-dimensional scaffolds and tissue culture systems

Country Status (2)

Country Link
AU (1) AU5767900A (en)
WO (1) WO2001000783A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314340B2 (en) 2009-02-27 2016-04-19 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10213809C1 (en) * 2002-03-27 2003-12-04 Innovacell Biotechnologie Gmbh Cell carrier and method for its production
AU2003218572B2 (en) * 2002-04-08 2009-08-20 Octane Biotech, Inc. Automated tissue engineering system
WO2004101743A2 (en) * 2003-05-06 2004-11-25 Bellbrook Labs, Llc Three dimensional cell cultures in a microscale fluid handling system
GB0313755D0 (en) * 2003-06-13 2003-07-23 Isis Innovation Monitoring method
WO2007008057A1 (en) * 2005-07-14 2007-01-18 Erasmus University Medical Center Rotterdam Tissue vitality monitoring system and method and surgical technique
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
CN105992816B (en) 2013-11-16 2018-04-17 泰尔茂比司特公司 Cell amplification in bioreactor
JP6783143B2 (en) 2014-03-25 2020-11-11 テルモ ビーシーティー、インコーポレーテッド Passive replenishment of medium
CN106715676A (en) 2014-09-26 2017-05-24 泰尔茂比司特公司 Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
JP7393945B2 (en) 2017-03-31 2023-12-07 テルモ ビーシーティー、インコーポレーテッド cell proliferation
CN114958772A (en) 2017-09-01 2022-08-30 隆萨沃克斯维尔股份有限公司 End-to-end cell therapy automation
WO2019197522A1 (en) * 2018-04-11 2019-10-17 Københavns Universitet Sensor functionalised bioink
KR20210107749A (en) 2018-12-21 2021-09-01 옥테인 바이오테크 인코포레이티드 Carousel for modular biological production units
US11718833B2 (en) 2018-12-21 2023-08-08 Lonza Walkersville, Inc. Automated production of viral vectors
WO2020132743A1 (en) 2018-12-28 2020-07-02 Octane Biotech Inc. Cell culture and tissue engineering systems with controlled environmental zones
KR20210125510A (en) 2019-02-08 2021-10-18 론자 워커스빌 아이엔씨. Cell Concentration Methods and Apparatus for Use in Automated Bioreactors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004645A1 (en) * 1988-10-21 1990-05-03 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
WO1999047922A2 (en) * 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004645A1 (en) * 1988-10-21 1990-05-03 Molecular Devices Corporation Methods and apparatus for detecting the effect of cell affecting agents on living cells
WO1999047922A2 (en) * 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314340B2 (en) 2009-02-27 2016-04-19 University of Pittsburgh—of the Commonwealth System of Higher Education Joint bioscaffolds

Also Published As

Publication number Publication date
WO2001000783A2 (en) 2001-01-04
AU5767900A (en) 2001-01-31

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