WO2001034660A3 - Screening and analysis of polymers, specialty chemicals and catalysts using radiography - Google Patents

Screening and analysis of polymers, specialty chemicals and catalysts using radiography Download PDF

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Publication number
WO2001034660A3
WO2001034660A3 PCT/US2000/030720 US0030720W WO0134660A3 WO 2001034660 A3 WO2001034660 A3 WO 2001034660A3 US 0030720 W US0030720 W US 0030720W WO 0134660 A3 WO0134660 A3 WO 0134660A3
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WO
WIPO (PCT)
Prior art keywords
catalysts
methods
polymers
analysis
chemical
Prior art date
Application number
PCT/US2000/030720
Other languages
French (fr)
Other versions
WO2001034660A2 (en
Inventor
Christopher D Tagge
Robert B Wilson
Seajin Oh
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Priority to AU14765/01A priority Critical patent/AU1476501A/en
Publication of WO2001034660A2 publication Critical patent/WO2001034660A2/en
Publication of WO2001034660A3 publication Critical patent/WO2001034660A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/088—Investigating volume, surface area, size or distribution of pores; Porosimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
    • G01N5/04—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid by removing a component, e.g. by evaporation, and weighing the remainder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00574—Chemical means radioactive
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks

Abstract

The invention relates to methods, using radiography, for the analysis of chemical compounds, such as polymers, specialty chemicals, and catalysts. In particular, the methods of the invention provide methods, which may be carried out in a highly parallel manner, for the synthesis and analysis of chemical compounds in a high-throughput or combinatorial manner. According to the invention, a substrate having a plurality of reaction regions is employed. Next, polymerization, synthesis or adsorption steps are carried out with one or more radiolabeled reagents. The radioactivity in the resulting product provides a measure of various physical properties. For instance, the methods of the invention may be used to determine the comonomer content of polymers, the productivity of catalysts, and/or the incorporation of a reagent in a specialty chemical. In addition, the invention provides means for determining a variety of chemical and physical properties of porous catalysts, including surface area, the number of active sites, the number of acidic or basic sites, pore size distribution, and chemisorption.
PCT/US2000/030720 1999-11-09 2000-11-09 Screening and analysis of polymers, specialty chemicals and catalysts using radiography WO2001034660A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14765/01A AU1476501A (en) 1999-11-09 2000-11-09 Screening and analysis of polymers, specialty chemicals and catalysts using radiography

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16434299P 1999-11-09 1999-11-09
US60/164,342 1999-11-09
US16722799P 1999-11-24 1999-11-24
US60/167,227 1999-11-24
US22441100P 2000-08-10 2000-08-10
US60/224,411 2000-08-10

Publications (2)

Publication Number Publication Date
WO2001034660A2 WO2001034660A2 (en) 2001-05-17
WO2001034660A3 true WO2001034660A3 (en) 2001-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030720 WO2001034660A2 (en) 1999-11-09 2000-11-09 Screening and analysis of polymers, specialty chemicals and catalysts using radiography

Country Status (2)

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AU (1) AU1476501A (en)
WO (1) WO2001034660A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10206988A1 (en) † 2002-02-19 2003-08-21 Basf Ag Process with high sample throughput for determining the quality of polymerization catalysts
GB0206117D0 (en) * 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7854902B2 (en) 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
WO2008118808A1 (en) 2007-03-23 2008-10-02 Advion Bioscience, Inc. Liquid chromatography-mass spectrometry
CN105116013A (en) * 2015-04-23 2015-12-02 山东农业大学 Method for determining influence of metal ions on protease hydrolysis of soybean protein isolate

Citations (8)

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Publication number Priority date Publication date Assignee Title
DE1442527A1 (en) * 1964-02-15 1968-10-31 Grillo Werke Ag Use of anodic metal oxide layers as a metering carrier
US3814769A (en) * 1969-05-01 1974-06-04 Mallinckrodt Chemical Works Catalyzed radioiodine exchange
US5088316A (en) * 1989-09-27 1992-02-18 Versar, Inc. Apparatus and method for testing material samples for gas diffusion characteristics
WO1997028168A1 (en) * 1996-02-01 1997-08-07 Pharmagenics, Inc. Non-nucleotide phosphorous ester oligomers
WO1997032208A1 (en) * 1996-02-28 1997-09-04 Technology Licensing Co. L.L.C. Catalyst testing process and apparatus
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
WO1999005318A1 (en) * 1997-07-22 1999-02-04 Symyx Technologies Encoding of organometallic libraries
WO1999051546A1 (en) * 1998-04-02 1999-10-14 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1442527A1 (en) * 1964-02-15 1968-10-31 Grillo Werke Ag Use of anodic metal oxide layers as a metering carrier
US3814769A (en) * 1969-05-01 1974-06-04 Mallinckrodt Chemical Works Catalyzed radioiodine exchange
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5088316A (en) * 1989-09-27 1992-02-18 Versar, Inc. Apparatus and method for testing material samples for gas diffusion characteristics
WO1997028168A1 (en) * 1996-02-01 1997-08-07 Pharmagenics, Inc. Non-nucleotide phosphorous ester oligomers
WO1997032208A1 (en) * 1996-02-28 1997-09-04 Technology Licensing Co. L.L.C. Catalyst testing process and apparatus
WO1999005318A1 (en) * 1997-07-22 1999-02-04 Symyx Technologies Encoding of organometallic libraries
WO1999051546A1 (en) * 1998-04-02 1999-10-14 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
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MCNEILL AND STRAITON: "Copolymerization of methyl methacrylate with 36Cl-Vinyl Chloride", EUROPEAN POLYMER JOURNAL, vol. 13, 1977, pages 17 - 18, XP000997685 *
SCHRÖDER U AND SCHÖÖN N-H: "Radioactive Tracer Techniques for Study of Reactions on Industrial Catalysts", JOURNAL OF CATALYSIS, vol. 143, 1993, pages 381 - 387, XP002169192 *

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Publication number Publication date
AU1476501A (en) 2001-06-06
WO2001034660A2 (en) 2001-05-17

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