WO2001034846A3 - Direct mapping of dna chips to detector arrays - Google Patents

Direct mapping of dna chips to detector arrays Download PDF

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Publication number
WO2001034846A3
WO2001034846A3 PCT/US2000/041799 US0041799W WO0134846A3 WO 2001034846 A3 WO2001034846 A3 WO 2001034846A3 US 0041799 W US0041799 W US 0041799W WO 0134846 A3 WO0134846 A3 WO 0134846A3
Authority
WO
WIPO (PCT)
Prior art keywords
chip
detector
address
detector arrays
dna chips
Prior art date
Application number
PCT/US2000/041799
Other languages
French (fr)
Other versions
WO2001034846A2 (en
Inventor
Martin Blumenfeld
Joseph J Talghader
Mark A Sanders
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Priority to EP00991918A priority Critical patent/EP1228248A2/en
Priority to JP2001536771A priority patent/JP2003515107A/en
Priority to CA002388034A priority patent/CA2388034A1/en
Priority to AU36403/01A priority patent/AU3640301A/en
Publication of WO2001034846A2 publication Critical patent/WO2001034846A2/en
Publication of WO2001034846A3 publication Critical patent/WO2001034846A3/en

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T1/00—General purpose image data processing
    • G06T1/0007—Image acquisition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products

Abstract

A device for detecting the pattern of polynucleic acid hybridization to a surface includes a positioning device for receiving a nucleic acid chip and keeping the chip in a sampling position. The sample surface has sequences of nucleic acids immobilized thereto, with each sequence being immobilized to a particular chip address. The device further includes an electronic light detector array comprising detector pixels, the detector pixels being sensors located at particular detector pixel addresses, wherein the positioning device places the sample surface of the chip at a well-defined position relative to the electronic light detector array so that light leaving a chip address is substantially directed onto at least one detector pixel with an address that is correlated to the chip address.
PCT/US2000/041799 1999-11-04 2000-11-02 Direct mapping of dna chips to detector arrays WO2001034846A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00991918A EP1228248A2 (en) 1999-11-04 2000-11-02 Direct mapping of dna chips to detector arrays
JP2001536771A JP2003515107A (en) 1999-11-04 2000-11-02 Direct mapping of DNA chips to detector arrays
CA002388034A CA2388034A1 (en) 1999-11-04 2000-11-02 Direct mapping of dna chips to detector arrays
AU36403/01A AU3640301A (en) 1999-11-04 2000-11-02 Direct mapping of dna chips to detector arrays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/434,027 1999-11-04
US09/434,027 US6784982B1 (en) 1999-11-04 1999-11-04 Direct mapping of DNA chips to detector arrays

Publications (2)

Publication Number Publication Date
WO2001034846A2 WO2001034846A2 (en) 2001-05-17
WO2001034846A3 true WO2001034846A3 (en) 2002-01-17

Family

ID=23722513

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/041799 WO2001034846A2 (en) 1999-11-04 2000-11-02 Direct mapping of dna chips to detector arrays

Country Status (6)

Country Link
US (3) US6784982B1 (en)
EP (1) EP1228248A2 (en)
JP (1) JP2003515107A (en)
AU (1) AU3640301A (en)
CA (1) CA2388034A1 (en)
WO (1) WO2001034846A2 (en)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
ES2441412T3 (en) * 2001-03-09 2014-02-04 Trovagene, Inc. Conjugated probes and optical analyte detection
EP1373467A4 (en) * 2001-03-28 2007-06-06 Genetech Biotechnology Shangai Device and method for detection of multiple analytes
JP2003014741A (en) * 2001-05-25 2003-01-15 Akihiro Fujimura Method of manufacturing mosaic reagent, and so on, and its product and manufacturing device
US7338168B2 (en) * 2001-07-06 2008-03-04 Palantyr Research, Llc Particle analyzing system and methodology
US7109464B2 (en) * 2001-07-06 2006-09-19 Palantyr Research, Llc Semiconductor imaging system and related methodology
US7248716B2 (en) * 2001-07-06 2007-07-24 Palantyr Research, Llc Imaging system, methodology, and applications employing reciprocal space optical design
AU2002322458A1 (en) 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
DE60332406D1 (en) 2002-03-15 2010-06-17 Affymetrix Inc System and method for scanning biological materials
US7179654B2 (en) * 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US7232547B2 (en) * 2002-03-22 2007-06-19 Marshfield Clinic Apparatus and method for testing and continuously reading low-volume samples
US7154598B2 (en) 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
US20060127946A1 (en) * 2002-08-16 2006-06-15 Montagu Jean I Reading of fluorescent arrays
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
DK1424547T3 (en) * 2002-10-10 2007-04-10 Illinois Tool Works Testing of samples
CN100383573C (en) * 2002-12-02 2008-04-23 3M创新有限公司 Illumination system using a plurality of light sources
AU2003290429A1 (en) * 2002-12-25 2004-07-22 Casio Computer Co., Ltd. Optical dna sensor, dna reading apparatus, identification method of dna and manufacturing method of optical dna sensor
AU2003900924A0 (en) * 2003-02-28 2003-03-13 Medsaic Pty Ltd Imaging device
US20050116942A1 (en) * 2003-09-26 2005-06-02 Vander Jagt Peter G. Color measurement instrument
US20050116635A1 (en) * 2003-12-02 2005-06-02 Walson James E. Multiple LED source and method for assembling same
US7329887B2 (en) * 2003-12-02 2008-02-12 3M Innovative Properties Company Solid state light device
US7250611B2 (en) * 2003-12-02 2007-07-31 3M Innovative Properties Company LED curing apparatus and method
US7403680B2 (en) * 2003-12-02 2008-07-22 3M Innovative Properties Company Reflective light coupler
US20050116235A1 (en) * 2003-12-02 2005-06-02 Schultz John C. Illumination assembly
US7456805B2 (en) 2003-12-18 2008-11-25 3M Innovative Properties Company Display including a solid state light device and method using same
US20050221351A1 (en) * 2004-04-06 2005-10-06 Affymetrix, Inc. Methods and devices for microarray image analysis
US7939022B2 (en) * 2004-08-05 2011-05-10 Avago Technologies General Ip (Singapore) Pte. Ltd. Integration of colorimetric transducers and detector
US20060054801A1 (en) * 2004-08-25 2006-03-16 Long-Song Cheng Biochip scanning device
US7585664B2 (en) * 2004-10-14 2009-09-08 The Hong Kong University Of Science And Technology Integrated circuit optical detector for biological detection
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7405831B2 (en) 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US8351026B2 (en) 2005-04-22 2013-01-08 Affymetrix, Inc. Methods and devices for reading microarrays
US20060252070A1 (en) * 2005-04-28 2006-11-09 Applera Corporation Multi-Color Light Detection With Imaging Detectors
US7738086B2 (en) * 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US20070097364A1 (en) * 2005-05-09 2007-05-03 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
EP1886257A1 (en) * 2005-05-11 2008-02-13 Optosecurity Inc. Method and system for screening luggage items, cargo containers or persons
US20070041613A1 (en) * 2005-05-11 2007-02-22 Luc Perron Database of target objects suitable for use in screening receptacles or people and method and apparatus for generating same
US7991242B2 (en) 2005-05-11 2011-08-02 Optosecurity Inc. Apparatus, method and system for screening receptacles and persons, having image distortion correction functionality
CA2616376A1 (en) * 2005-07-25 2007-02-01 Duke University Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
US8320650B2 (en) * 2005-11-30 2012-11-27 Lawrence Livermore National Security, Llc In vivo spectral micro-imaging of tissue
US9445025B2 (en) 2006-01-27 2016-09-13 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
US8055098B2 (en) 2006-01-27 2011-11-08 Affymetrix, Inc. System, method, and product for imaging probe arrays with small feature sizes
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) * 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
EP2001352A4 (en) * 2006-03-17 2010-04-07 Univ Duke Monte carlo based model of fluorescence in turbid media and methods and systems for using same to determine intrinsic fluorescence of turbid media
WO2007126827A2 (en) * 2006-03-30 2007-11-08 Duke University Optical assay system for intraoperative assessment of tumor margins
CA2584683A1 (en) * 2006-04-20 2007-10-20 Optosecurity Inc. Apparatus, method and system for screening receptacles and persons
JP2007298380A (en) * 2006-04-28 2007-11-15 Hamamatsu Photonics Kk Sample holding member
US7899232B2 (en) * 2006-05-11 2011-03-01 Optosecurity Inc. Method and apparatus for providing threat image projection (TIP) in a luggage screening system, and luggage screening system implementing same
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
US8494210B2 (en) * 2007-03-30 2013-07-23 Optosecurity Inc. User interface for use in security screening providing image enhancement capabilities and apparatus for implementing same
US7803609B2 (en) * 2006-07-21 2010-09-28 Affymetrix, Inc. System, method, and product for generating patterned illumination
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
EP4220138A1 (en) * 2006-09-01 2023-08-02 Pacific Biosciences of California, Inc. Substrates, systems and methods for analyzing materials
US20080080059A1 (en) * 2006-09-28 2008-04-03 Pacific Biosciences Of California, Inc. Modular optical components and systems incorporating same
US7659968B2 (en) 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
JPWO2008099778A1 (en) * 2007-02-14 2010-05-27 株式会社ニコン Slit scanning confocal microscope
WO2008103486A1 (en) * 2007-02-23 2008-08-28 Duke University Scaling method for fast monte carlo simulation of diffuse reflectance spectra
WO2008118934A1 (en) 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US7623242B2 (en) * 2007-06-21 2009-11-24 Gideon Eden Device and method for monitoring multiple chemical samples with a fluorescent tube
GB2451443B (en) * 2007-07-30 2012-12-26 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
DE102007045897A1 (en) * 2007-09-26 2009-04-09 Carl Zeiss Microimaging Gmbh Method for the microscopic three-dimensional imaging of a sample
EP2194878A2 (en) * 2007-09-27 2010-06-16 Duke University Optical assay system with a multi-probe imaging array
US9820655B2 (en) * 2007-09-28 2017-11-21 Duke University Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo or a diffusion algorithm
JP2009236791A (en) * 2008-03-28 2009-10-15 Hitachi High-Technologies Corp Defect inspecting method and defect inspecting device
US20110105865A1 (en) * 2008-04-24 2011-05-05 Duke University Diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering
CA2974241C (en) 2008-09-16 2020-01-07 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US20110201942A1 (en) * 2008-10-27 2011-08-18 Koninklijke Philips Electronics N.V. Device and method for optically examining the interior of a body part
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8449842B2 (en) * 2009-03-19 2013-05-28 Thermo Scientific Portable Analytical Instruments Inc. Molecular reader
AU2010249678B2 (en) * 2009-05-19 2014-08-28 The Regents Of The University Of California Multi-directional microfluidic devices and methods
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
US9041790B2 (en) 2009-10-28 2015-05-26 Alentic Microscience Inc. Microscopy imaging
US9075225B2 (en) 2009-10-28 2015-07-07 Alentic Microscience Inc. Microscopy imaging
US9091637B2 (en) 2009-12-04 2015-07-28 Duke University Smart fiber optic sensors systems and methods for quantitative optical spectroscopy
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8467061B2 (en) 2010-02-19 2013-06-18 Pacific Biosciences Of California, Inc. Integrated analytical system and method
JP5707758B2 (en) * 2010-07-13 2015-04-30 ソニー株式会社 Imaging apparatus, imaging system, surgical navigation system, and imaging method
CA2816100A1 (en) 2010-11-23 2012-05-31 The Regents Of The University Of California Multi-directional microfluidic devices comprising a pan-capture binding region and methods of using the same
CA2819237A1 (en) 2010-12-03 2012-06-07 The Regents Of The University Of California Protein renaturation microfluidic devices and methods of making and using the same
AT510750B1 (en) * 2010-12-14 2012-09-15 Greiner Bio One Gmbh Measurement arrangement for the quantitative optical evaluation of a chemical reaction
US9828696B2 (en) 2011-03-23 2017-11-28 Nanohmics, Inc. Method for assembly of analyte filter arrays using biomolecules
US9252175B2 (en) 2011-03-23 2016-02-02 Nanohmics, Inc. Method for assembly of spectroscopic filter arrays using biomolecules
KR102067367B1 (en) 2011-09-07 2020-02-11 라피스캔 시스템스, 인코포레이티드 X-ray inspection method that integrates manifest data with imaging/detection processing
WO2013089887A2 (en) 2011-09-30 2013-06-20 The Regents Of The University Of California Microfluidic devices and methods for assaying a fluid sample using the same
US20140368822A1 (en) * 2011-12-30 2014-12-18 Burbidge Pty Ltd Media absorbency determination
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
US9223084B2 (en) 2012-12-18 2015-12-29 Pacific Biosciences Of California, Inc. Illumination of optical analytical devices
US10502666B2 (en) 2013-02-06 2019-12-10 Alentic Microscience Inc. Sample processing improvements for quantitative microscopy
WO2014130900A1 (en) 2013-02-22 2014-08-28 Pacific Biosciences Of California, Inc. Integrated illumination of optical analytical devices
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US9671368B2 (en) 2013-05-10 2017-06-06 The Regents Of The University Of California Two-dimensional microfluidic devices and methods of using the same
FR3007534A1 (en) * 2013-06-20 2014-12-26 St Microelectronics Crolles 2 PRODUCTION OF A NANOSTRUCTURE SPECTRAL FILTER
CN110058005A (en) 2013-06-26 2019-07-26 阿兰蒂克微科学股份有限公司 It is improved for micro- sample treatment
CN103604784B (en) * 2013-11-05 2016-05-18 浙江工业大学 Array sensing chip is analyzed in the fluoroscopic examination of CMOS contact
MX360883B (en) 2013-12-10 2018-11-21 Illumina Inc Biosensors for biological or chemical analysis and methods of manufacturing the same.
JP2017054839A (en) * 2014-01-29 2017-03-16 パナソニックＩｐマネジメント株式会社 Imaging device, electronic preparation, and solid state image pick-up device
JP6545457B2 (en) 2014-03-07 2019-07-17 パナソニック株式会社 Preparation plate, transparent plate, preparation method of preparation plate, slide glass, image photographing device, image photographing method, preparation plate preparing device, and preparation part set
US9606068B2 (en) 2014-08-27 2017-03-28 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices
CN113064236B (en) 2015-03-16 2022-11-01 加利福尼亚太平洋生物科学股份有限公司 Integrated device and system for free space optical coupling
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
CN107924027B (en) 2015-06-12 2024-01-23 加利福尼亚太平洋生物科学股份有限公司 Integrated target waveguide device and system for optical coupling
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
US10386365B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using ionic species diffusion
US10386351B2 (en) 2015-12-07 2019-08-20 Nanohmics, Inc. Methods for detecting and quantifying analytes using gas species diffusion
EP3420563A4 (en) 2016-02-22 2020-03-11 Rapiscan Systems, Inc. Systems and methods for detecting threats and contraband in cargo
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
JP7356351B2 (en) 2016-12-12 2023-10-04 エクセラ・バイオサイエンシーズ・インコーポレイテッド Methods and systems for screening using microcapillary arrays
CN106770131A (en) * 2017-01-17 2017-05-31 清华大学 Three-dimensional ultraphotic composes micro imaging system and imaging method
EP3610012A4 (en) * 2017-04-10 2020-12-23 Xcella Biosciences, Inc. High-throughput absorbance measurements of samples in microcapillary arrays
EP3711095B1 (en) 2017-12-26 2024-03-06 Illumina, Inc. Sensor system
NL2020636B1 (en) * 2017-12-28 2019-07-08 Illumina Inc Light energy fluorescence excitation
DE102018104693A1 (en) * 2018-03-01 2019-09-05 Carl Zeiss Microscopy Gmbh Method for accelerated, high-resolution scanning microscopy
FR3085072B1 (en) 2018-08-14 2021-04-16 Commissariat Energie Atomique SAMPLE OBSERVATION PROCESS
WO2020076299A1 (en) 2018-10-09 2020-04-16 Hewlett-Packard Development Company, L.P. Flat-form imaging for microscopic objects
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. Methods and systems for time-gated fluorescent-based detection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5672881A (en) * 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
WO1999036578A1 (en) * 1998-01-14 1999-07-22 Lakowicz Joseph R Method and composition for detecting the presence of a nucleic acid sequence in a sample
WO2000012123A2 (en) * 1998-08-28 2000-03-09 Febit Ferrarius Biotechnology Gmbh Method and measuring device for determining a plurality of analytes in a sample

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2378883A (en) * 1943-03-24 1945-06-19 Detroit Lubricator Co Control device
JPS50154013A (en) 1974-06-01 1975-12-11
US4002829A (en) 1974-08-29 1977-01-11 W. R. Grace & Co. Autosynchronous optical scanning and recording laser system with fiber optic light detection
CH620297A5 (en) 1976-05-04 1980-11-14 Green James E Method for the optical analysis of a sample in a double-resolution apparatus, and apparatus for implementation thereof
US4088561A (en) * 1977-06-27 1978-05-09 The United States Of America As Represented By The United States Department Of Energy Apparatus for electrophoresis separation
US4600951A (en) 1983-12-20 1986-07-15 At&T Technologies, Inc. Scanning sample, signal generation, data digitizing and retiming system
US4721851A (en) 1985-04-30 1988-01-26 Ricoh Company, Ltd. Image reading device using fiber optic bundles configured differently at each end
US4886975A (en) 1986-02-14 1989-12-12 Canon Kabushiki Kaisha Surface examining apparatus for detecting the presence of foreign particles on two or more surfaces
JPH0727125B2 (en) 1986-05-23 1995-03-29 株式会社日立製作所 Optical scanning device
US4922092A (en) * 1986-11-26 1990-05-01 Image Research Limited High sensitivity optical imaging apparatus
US4875780A (en) 1988-02-25 1989-10-24 Eastman Kodak Company Method and apparatus for inspecting reticles
US4849645A (en) 1988-03-04 1989-07-18 American Telephone And Telegraph Company Substrate inspection system having two scattered light detecting bundles orthogonally positioned to each other
US5293563A (en) 1988-12-29 1994-03-08 Sharp Kabushiki Kaisha Multi-level memory cell with increased read-out margin
US4941309A (en) * 1989-03-02 1990-07-17 Certainteed Corporation Panel packaging system
US5925525A (en) 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
JPH04296642A (en) 1991-03-27 1992-10-21 Ricoh Co Ltd Sample surface-defect detecting device
US5378883A (en) 1991-07-19 1995-01-03 Omniplanar Inc. Omnidirectional wide range hand held bar code reader
US5216485A (en) 1991-09-04 1993-06-01 International Business Machines Corporation Advanced via inspection tool (avit)
JP3067331B2 (en) 1991-10-30 2000-07-17 株式会社ニコン microscope
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5798831A (en) 1991-12-19 1998-08-25 Nikon Corporation Defect inspecting apparatus and defect inspecting method
JPH06148085A (en) 1992-11-12 1994-05-27 Sony Corp Method and device for detecting foreign matter on wafer
US5313542A (en) 1992-11-30 1994-05-17 Breault Research Organization, Inc. Apparatus and method of rapidly measuring hemispherical scattered or radiated light
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
MY111204A (en) 1993-02-26 1999-09-30 Mitsubishi Chem Ind Apparatus and method for separating a liquid mixture
US5424841A (en) * 1993-05-28 1995-06-13 Molecular Dynamics Apparatus for measuring spatial distribution of fluorescence on a substrate
US5861242A (en) 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5471066A (en) 1993-08-26 1995-11-28 Nikon Corporation Defect inspection apparatus of rotary type
JPH0798276A (en) 1993-09-28 1995-04-11 Hitachi Electron Eng Co Ltd Determining device for appangement of dna base
US5732162A (en) 1993-10-28 1998-03-24 Xerox Corporation Two dimensional linearity and registration error correction in a hyperacuity printer
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5928905A (en) 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
JP3425615B2 (en) 1994-03-24 2003-07-14 科学技術庁長官官房会計課長 Scanning near-field atomic force microscope
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
DE69527585T2 (en) 1994-06-08 2003-04-03 Affymetrix Inc Method and device for packaging chips
JP3068413B2 (en) 1994-07-13 2000-07-24 日立電子エンジニアリング株式会社 DNA base sequencer
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US5710000A (en) 1994-09-16 1998-01-20 Affymetrix, Inc. Capturing sequences adjacent to Type-IIs restriction sites for genomic library mapping
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
JPH09145631A (en) 1995-11-29 1997-06-06 Nikon Corp Surface foreign matter detector
US5871628A (en) 1996-08-22 1999-02-16 The University Of Texas System Automatic sequencer/genotyper having extended spectral response
US5872623A (en) * 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US5856104A (en) 1996-10-28 1999-01-05 Affymetrix, Inc. Polymorphisms in the glucose-6 phosphate dehydrogenase locus
DE19707227A1 (en) 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Light scanner
US5929985A (en) * 1997-03-18 1999-07-27 Sandia Corporation Multispectral imaging probe
US5874837A (en) * 1997-04-28 1999-02-23 Pericom Semiconductor Corp. CMOS PECL driver with programmable current for varying voltage swings and termination types
US6545334B2 (en) 1997-12-19 2003-04-08 Imec Vzw Device and a method for thermal sensing
US6140653A (en) * 1998-03-27 2000-10-31 Vysis, Inc. Large-field fluorescence imaging apparatus
ATE255727T1 (en) 1998-07-17 2003-12-15 Vertex Pharma San Diego Llc DETECTOR AND SCREENING DEVICE FOR ION CHANNELS
DE19914279C1 (en) 1999-03-25 2000-09-07 Jena Optronik Gmbh Sensor for optical examination of stimulated sample pixels on e.g. nano-titration screening plates or bio-chips for gene analysis, employs e.g. a liquid crystal matrix shutter and fiber optics with photomultiplier detection
US20030133009A1 (en) * 1999-04-09 2003-07-17 Carl S Brown System and method for detecting with high resolution a large, high content field
AU4990500A (en) 1999-05-07 2000-11-21 Sherry L. Acanfora-Florin Method and system for remotely collecting and evaluating chemical/biochemical information
US7072034B2 (en) 2001-06-08 2006-07-04 Kla-Tencor Corporation Systems and methods for inspection of specimen surfaces
US7113624B2 (en) 2002-10-15 2006-09-26 Palo Alto Research Center Incorporated Imaging apparatus and method employing a large linear aperture

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5672881A (en) * 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
WO1999036578A1 (en) * 1998-01-14 1999-07-22 Lakowicz Joseph R Method and composition for detecting the presence of a nucleic acid sequence in a sample
WO2000012123A2 (en) * 1998-08-28 2000-03-09 Febit Ferrarius Biotechnology Gmbh Method and measuring device for determining a plurality of analytes in a sample

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US7145645B2 (en) 2006-12-05
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EP1228248A2 (en) 2002-08-07
US6784982B1 (en) 2004-08-31
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