WO2001052914A1 - Expanded ptfe drug delivery graft - Google Patents
Expanded ptfe drug delivery graft Download PDFInfo
- Publication number
- WO2001052914A1 WO2001052914A1 PCT/US2001/002061 US0102061W WO0152914A1 WO 2001052914 A1 WO2001052914 A1 WO 2001052914A1 US 0102061 W US0102061 W US 0102061W WO 0152914 A1 WO0152914 A1 WO 0152914A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- graft
- porous
- hollow tubing
- drug delivery
- drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
Definitions
- the present invention relates to medical devices, and more particularly, to an expanded polytetrafluoroethylene (ePTFE) based graft for delivering an agent into a natural tissue conduit, e.g., a blood vessel.
- ePTFE expanded polytetrafluoroethylene
- the concentration of drug on the stent or other similar delivery devices will diminish, through drug inactivation, degradation, or dilution.
- the therapeutic agent may need to be refreshed or even changed after implant of the device.
- these existing devices are not capable of delivering drugs to an internal lumen along the entire length of the graft.
- a drug delivery graft capable of delivering a drug or any other agent to the internal lumen along the entire length of the graft, or restrict delivery to a finite area on the graft such that the agent may be renewed or altered after implant of the graft.
- a desirable drug delivery graft could be implanted in the same fashion as regular vascular grafts.
- an improved expanded polytetrafluoroethylene (ePTFE) drug delivery graft is provided.
- the invention can be used, for example, as a vascular graft providing sustained release of a selected bioactive or diagnostic agent directly into a blood or other fluid flow pathway.
- the graft is capable of delivering the bioactive or diagnostic agent to the internal lumen of a vascular graft along the entire length, or of restricting delivery to a finite area of the vascular graft.
- Various ePTFE grafts that are reinforced by external beading are well known in the art.
- the present design utilizes a hollow tubing as a drug conduit.
- the hollow tubing behaves much like the existing low profile solid beading in that it has a small diameter and can be readily implanted into the body.
- the hollow tubing of the present invention serves as both a spiral support and drug conduit.
- a simple tubular ePTFE graft is used, which is well known to be extremely porous.
- a hollow tubing of non-porous PTFE, fluoroethylene polymer (FEP) or other implantable polymer is wrapped around the graft and laminated or adhered in place.
- the hollow tubing may be wrapped helically; alternatively other arrangements (e.g., end to end loops) can be used. Before the wrapping occurs one surface of the hollow tubing is cut away (for example, laser cut), punctured repeatedly or otherwise rendered porous.
- the drug When an agent such as a drug is injected into the hollow tubing, e.g., from an infusion pump or a subcutaneous access port, the drug flows through the hollow tubing and leaks through the cut or porous region and diffuses into the outer surface of the ePTFE graft.
- the drug diffuses into the graft where it mixes into the blood flowing therethrough and influences biological processes along the circulatory system.
- the dispensed material could have either systemic effect or have limited local effect.
- One particularly attractive use of the device is to dispense drugs to limit the restenosis that frequently occurs due to tissue proliferation at the site of anastimosis of an ePTFE graft to a blood vessel.
- the invention takes advantage of the well-known porosity of an ePTFE graft.
- Impregnation of ePTFE grafts with therapeutic agents has been previously disclosed.
- the present invention allows the therapeutic agents to be renewed or altered following implant of the graft, something that is not possible with simple drug-impregnated graft materials.
- FIG. 1 is a side view of a drug delivery graft according to an embodiment of the present invention
- Fig. 2 is a side view of a hollow tubing according to an embodiment of the present invention.
- Fig. 3 is a cross-sectional view of the drug delivery graft showing a cut portion of the hollow tubing according to an embodiment of the present invention.
- Fig. 4 is a cross-sectional view of the drug delivery graft showing a porous hollow tubing according to an embodiment of the present invention.
- Fig. 5 is a side view of an alternate embodiment of the drug delivery graft of the present invention.
- Fig. 6 is a side view of another alternate embodiment of the drug delivery graft of the present invention.
- the present invention satisfies the need for an improved drug delivery graft capable of delivering bioactive agents, including drugs, to an internal lumen of a graft, either along its entire length or in a localized area, through the use of hollow tubing on the outside of the graft.
- bioactive agents including drugs
- a side view of a drug delivery graft 10 in accordance with an embodiment of the present invention is illustrated.
- the drug delivery graft 10 comprises a graft 2, a hollow tubing 4, and a drug source 6.
- the hollow tubing 4 is wrapped (spiraled) in a helical fashion around an abluminal surface of the graft 2.
- the drug source 6 is connected to one end 14 of the hollow tubing 4.
- the graft 2 may be a standard clinical vascular graft of any shape or size comprised preferably of expanded PTFE, which material consists of a porous network of nodes and fibrils created during the expansion process. This porous network provides a somewhat permeable wall for the graft 2.
- the graft 2 can be constructed in a variety of sizes to allow a surgeon to select the appropriate size to accommodate a particular vascular application. Likewise, the porosity (internodal distance) of the graft can be varied to affect the rate of drug or agent release.
- the drug delivery graft 10 injects a drug or other agent into the bore of the hollow tubing 4 from the drug source 6.
- the drug source 6 can be any of a variety of commercially and technologically available systems that provide constant controlled rate delivery of an agent, such as a biologically activated mini pump that is either subcutaneously or extracorporeally located, an external mechanical pump, or an access port.
- an open end 14 of the hollow tubing 4 may be connected via a micro-catheter to a subcutaneous or other drug source.
- the agent delivered to the natural tissue conduit can be any substance, including any drug, and the device can be used for local or systemic delivery of such substances to prevent or treat a variety of disease syndromes or to promote or enhance desired activity within the body.
- a bioactive or diagnostic agent may include, for example, therapeutic or prophylactic agents, such as a drug, protein, enzyme, antibody or other agent, or cells that produce a drug, protein, enzyme, antibody, or other agent.
- the diagnostic material can include, for example, a radiolabeled antibody or antigen.
- the natural tissue conduit into which the agent is ultimately delivered may include any structure of a body that functions to transport substances and includes, but is not limited to, e.g., blood vessels of the cardiovascular system (arteries and veins), the lymphatic system, the intestinal tract (esophagus, stomach, the small and large intestines, and colon), the portal system of the liver, the gall bladder and bile duct, the urinary system (bladder, and urethra), the respiratory system (trachea, bronchi and bronchioles), and ducts and ductules connecting endocrine organs to other areas of the body.
- the device of the present invention can be used in any mammal or in any animal in which natural tissue conduits are found. Suitable dosage requirements and treatment regimens for any agent delivered can be determined and will vary depending upon the tissue targeted for therapy and upon the particular agent utilized.
- the hollow tubing 4 may be manufactured from a non-expanded or partially expanded small diameter PTFE tube or any other implantable polymer (e.g. FEP).
- the hollow tubing 4 may be manufactured in very small diameters (less than 1 mm) and long lengths (more than 10 feet) to accommodate all sizes of grafts.
- the prior art beading used solely for support purposes is a solid filament
- the hollow tubing 4 has a bore to provide fluid delivery to the graft 2.
- the hollow tubing 4 has an uncut portion 16 and a partially cut portion 12 (or a porous and less or non-porous region arrange circumferentially) that allows communication between the lumen of the hollow tubing 4 and the outside surface of the graft 2.
- communication between the lumen of the hollow tubing 4 and the outside surface of the graft 2 may be achieved by using a porous hollow tubing or a hollow tubing with mechanical or laser perforations.
- the hollow tubing 4 is shown generally cylindrical in shape, it should be appreciated that alternative designs are possible including a hollow tubing that is tapered along its length as well as one that has a stepped configuration or has other, non-circular cross-sections.
- the graft may be tapered or stepped or of a special shape, such as cuffed, as is known in the art.
- a specified length of a tube made of PTFE, FEP or other any other implantable polymer may be loaded on a mandrel to secure the tube in a rigid fashion.
- the loaded tube may be placed in a cutting device where a defined portion of the tube is cut in the longitudinal direction.
- a semi-circular "half-tube" C-shaped section 12 may be created in the middle of the tube to create the hollow tubing 4.
- the cutting device may comprise a LASER cutting device.
- the tube may be punctured repeatedly or otherwise rendered porous to allow release of the agent into the ePTFE of the graft.
- One end 18 of the hollow tubing 4 may be sealed mechanically, for example by a crimp, or by a heating process to terminate the lumen.
- the terminated end 18 may also be sealed with a silicon or other self-sealing material that can advantageously serve as a primer port for infusing an agent through, for example, a syringe.
- FIG. 3 a cross-sectional view of the drug delivery graft showing a cut portion of hollow tubing according to an embodiment of the present invention is illustrated.
- Hollow tubing 4 is wound spirally around the graft 2.
- a cutaway portion 12 of the hollow tubing 4 is laminated and secured against the outer surface of the graft 2, creating a drug outflow surface that communicates with the outer lumen of the graft 2.
- Fig. 4 shows a cross-sectional view of the drug delivery graft showing a porous hollow tubing 24 according to an alternative embodiment of the present invention.
- the porous hollow tubing 24 comprises perforations or pores 22 through which an agent or drug is dispensed onto and into the graft 2.
- the agent or drug is evenly distributed and diffuses into the graft 2 through the interstices of an agent infusion area 8.
- the rate at which the drug or other agent penetrates the porous wall of the graft 2 is determined by several factors, including the size and number of the pores and the size of the drug molecule.
- the graft 2 is capable of delivering drugs or any other agents to the internal lumen along the entire length of the graft 2, or of restricting delivery to a finite area on the graft 2.
- the spacing of the hollow tubing 4 along the graft 2 can be varied to concentrate dosages in certain areas of need.
- the spiraling of the hollow tubing 4 around the graft 2 as shown in Fig. 1 , could be combined with a traditional support beading spiraled around the graft 2 for additional support.
- Drug delivery graft 30 includes graft 32 and hollow tubing 34.
- the hollow tubing 34 is arranged longitudinally along the graft 32, rather than wrapped around spirally as in Fig. 1.
- the hollow tubing 34 is arranged in a snake-like fashion, longitudinally along the outside of the graft 32, and is connected to the drug source 6 at one end.
- the longitudinally arranged strips of hollow tubing 34 loop back at the ends of the graft so that a single continuous piece of hollow tubing is employed.
- hollow tubing 44 is arranged longitudinally along a graft 42 in a slightly different configuration to make up a drug delivery graft 40.
- the longitudinally arranged hollow tubing 44 is connected to manifolds 46 and 48 at each end.
- the manifold 46 located at a proximal end of the graft 42, is circumferentially arranged around the graft 42 and is also connected to the drug source 6.
- the manifold 48 located at a distal end of the graft 42 is cirumferentially arranged around the graft 42 in a closed loop.
- the drug provided from the drug source 6 flows into the manifold 46 where it is distributed to the longitudinally placed hollow tubing 44, flowing through the hollow tubing 44 and along the manifold 48, being distributed to the graft 42 in one of the above-mentioned methods shown in Figs 2-4.
- the hollow tubing can be spaced equidistant or varied depending on the required application.
- the spiraled or longitudinally-placed hollow tubing is sintered to the graft to adhere the hollow tubing to the graft in the same manner as existing standard grafts, adhering the cut (C-shaped) portion 12 and uncut hollow tubing portion 16 as shown in Fig. 3, or the porous hollow tubing 24 as shown in Fig. 4, along the length of the graft 2.
- any of a number of known adhesive agents can be used to attach the hollow tubing.
- the hollow tubing may be produced from a plastic material such as polypropylene, which can be adhered to the graft through a partial melting process.
- the design may use the existing low profile hollow tubing on existing grafts, for example IMPRAFIex ® grafts, manufactured by IMPRA (Tempe, Arizona), a Division of C.R. Bard, Inc., and can be implanted in the same fashion as regularly used existing vascular grafts.
- existing grafts for example IMPRAFIex ® grafts, manufactured by IMPRA (Tempe, Arizona), a Division of C.R. Bard, Inc.
- the devices of the present invention can function as improved vascular grafts such that the agent or drug to be delivered prevents or treats complications associated with conventional vascular graft placement, including but not limited to platelet deposition, coagulation, thrombosis, neointimal hyperplasia and fibrosis.
- complications associated with conventional vascular graft placement including but not limited to platelet deposition, coagulation, thrombosis, neointimal hyperplasia and fibrosis.
- One particularly attractive use of the drug delivery graft would be to dispense drugs or any other agent to limit the stenosis that frequently occurs at the site of anastimosis of an ePTFE graft to a blood vessel.
- agents that prevent restenosis of a blood vessel include, but are not limited to, a growth factor, a growth factor inhibitor, growth factor receptor antagonist, transcriptional repressor, translational repressor, antisense DNA, antisense RNA, replication inhibitor, anti- microtubule agents, inhibitory antibodies, antibodies directed against growth factors or their receptors, bifunctional molecules comprising a growth factor and a cytotoxin, and bifunctional molecules comprising an antibody and a cytotoxin.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001552961A JP4969752B2 (en) | 2000-01-20 | 2001-01-18 | PTFE drug delivery implant |
CA2397654A CA2397654C (en) | 2000-01-20 | 2001-01-18 | Expanded ptfe drug delivery graft |
MXPA02007107A MXPA02007107A (en) | 2000-01-20 | 2001-01-18 | Expanded ptfe drug delivery graft. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/488,625 US6355063B1 (en) | 2000-01-20 | 2000-01-20 | Expanded PTFE drug delivery graft |
US09/488,625 | 2000-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001052914A1 true WO2001052914A1 (en) | 2001-07-26 |
Family
ID=23940445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/002061 WO2001052914A1 (en) | 2000-01-20 | 2001-01-18 | Expanded ptfe drug delivery graft |
Country Status (8)
Country | Link |
---|---|
US (2) | US6355063B1 (en) |
EP (3) | EP2301592B1 (en) |
JP (1) | JP4969752B2 (en) |
CA (1) | CA2397654C (en) |
DE (1) | DE60035404T2 (en) |
ES (3) | ES2642111T3 (en) |
MX (1) | MXPA02007107A (en) |
WO (1) | WO2001052914A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6355063B1 (en) | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
US6926735B2 (en) * | 2002-12-23 | 2005-08-09 | Scimed Life Systems, Inc. | Multi-lumen vascular grafts having improved self-sealing properties |
US6936072B2 (en) | 1999-08-18 | 2005-08-30 | Intrinsic Therapeutics, Inc. | Encapsulated intervertebral disc prosthesis and methods of manufacture |
EP1708647A2 (en) * | 2004-01-30 | 2006-10-11 | Boston Scientific Santa Rosa Corporation | Inflatable porous implants and methods for drug delivery |
JP2007501676A (en) * | 2003-05-07 | 2007-02-01 | アリーヴァ メディカル インコーポレイテッド | Treatment of low back pain by restoring nutrient and waste exchange |
US9039741B2 (en) | 2005-12-28 | 2015-05-26 | Intrinsic Therapeutics, Inc. | Bone anchor systems |
US9226832B2 (en) | 2007-09-07 | 2016-01-05 | Intrinsic Therapeutics, Inc. | Interbody fusion material retention methods |
US9333087B2 (en) | 1999-08-18 | 2016-05-10 | Intrinsic Therapeutics, Inc. | Herniated disc repair |
US9706947B2 (en) | 1999-08-18 | 2017-07-18 | Intrinsic Therapeutics, Inc. | Method of performing an anchor implantation procedure within a disc |
US9867727B2 (en) | 1998-02-09 | 2018-01-16 | Trivascular, Inc. | Endovascular graft |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7204848B1 (en) | 1995-03-01 | 2007-04-17 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US20070073384A1 (en) * | 1995-03-01 | 2007-03-29 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US6428571B1 (en) * | 1996-01-22 | 2002-08-06 | Scimed Life Systems, Inc. | Self-sealing PTFE vascular graft and manufacturing methods |
US5871537A (en) * | 1996-02-13 | 1999-02-16 | Scimed Life Systems, Inc. | Endovascular apparatus |
US7947015B2 (en) * | 1999-01-25 | 2011-05-24 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US6955661B1 (en) * | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US7572245B2 (en) * | 2003-09-15 | 2009-08-11 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
WO2009033100A1 (en) | 2007-09-07 | 2009-03-12 | Intrinsic Therapeutics, Inc. | Bone anchoring systems |
US7553329B2 (en) * | 1999-08-18 | 2009-06-30 | Intrinsic Therapeutics, Inc. | Stabilized intervertebral disc barrier |
US7220281B2 (en) | 1999-08-18 | 2007-05-22 | Intrinsic Therapeutics, Inc. | Implant for reinforcing and annulus fibrosis |
US7998213B2 (en) | 1999-08-18 | 2011-08-16 | Intrinsic Therapeutics, Inc. | Intervertebral disc herniation repair |
US20040010317A1 (en) * | 1999-08-18 | 2004-01-15 | Gregory Lambrecht | Devices and method for augmenting a vertebral disc |
WO2004100841A1 (en) | 1999-08-18 | 2004-11-25 | Intrinsic Therapeutics, Inc. | Devices and method for augmenting a vertebral disc nucleus |
US6616876B1 (en) * | 2000-10-03 | 2003-09-09 | Atrium Medical Corporation | Method for treating expandable polymer materials |
US6923927B2 (en) * | 2000-10-03 | 2005-08-02 | Atrium Medical Corporation | Method for forming expandable polymers having drugs or agents included therewith |
US6979347B1 (en) * | 2000-10-23 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | Implantable drug delivery prosthesis |
US6758859B1 (en) * | 2000-10-30 | 2004-07-06 | Kenny L. Dang | Increased drug-loading and reduced stress drug delivery device |
US10398830B2 (en) | 2000-11-17 | 2019-09-03 | Vactronix Scientific, Llc | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
US9107605B2 (en) * | 2000-11-17 | 2015-08-18 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
US6656216B1 (en) * | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
US7547321B2 (en) * | 2001-07-26 | 2009-06-16 | Alveolus Inc. | Removable stent and method of using the same |
US7125464B2 (en) | 2001-12-20 | 2006-10-24 | Boston Scientific Santa Rosa Corp. | Method for manufacturing an endovascular graft section |
US7135038B1 (en) * | 2002-09-30 | 2006-11-14 | Advanced Cardiovascular Systems, Inc. | Drug eluting stent |
US20040093056A1 (en) | 2002-10-26 | 2004-05-13 | Johnson Lianw M. | Medical appliance delivery apparatus and method of use |
US7875068B2 (en) | 2002-11-05 | 2011-01-25 | Merit Medical Systems, Inc. | Removable biliary stent |
US7637942B2 (en) * | 2002-11-05 | 2009-12-29 | Merit Medical Systems, Inc. | Coated stent with geometry determinated functionality and method of making the same |
US7959671B2 (en) | 2002-11-05 | 2011-06-14 | Merit Medical Systems, Inc. | Differential covering and coating methods |
US7637934B2 (en) | 2003-03-31 | 2009-12-29 | Merit Medical Systems, Inc. | Medical appliance optical delivery and deployment apparatus and method |
BRPI0410324A (en) * | 2003-05-15 | 2006-05-23 | Biomerix Corp | implantable device, elastomeric matrix production lyophilization processes having a cross-linked structure, polymerization for cross-linked elastomeric matrix preparation and cross-linked composite elastomeric implant preparation, and method for treating an orthopedic disorder |
US8021418B2 (en) * | 2003-06-19 | 2011-09-20 | Boston Scientific Scimed, Inc. | Sandwiched radiopaque marker on covered stent |
DK1638485T3 (en) * | 2003-06-20 | 2011-05-02 | Intrinsic Therapeutics Inc | Device for delivery of an implant through an annular defect in an intervertebral disc |
US20040260300A1 (en) * | 2003-06-20 | 2004-12-23 | Bogomir Gorensek | Method of delivering an implant through an annular defect in an intervertebral disc |
US7131993B2 (en) * | 2003-06-25 | 2006-11-07 | Boston Scientific Scimed, Inc. | Varying circumferential spanned connectors in a stent |
US8021331B2 (en) | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
US7763077B2 (en) | 2003-12-24 | 2010-07-27 | Biomerix Corporation | Repair of spinal annular defects and annulo-nucleoplasty regeneration |
US8118864B1 (en) | 2004-05-25 | 2012-02-21 | Endovascular Technologies, Inc. | Drug delivery endovascular graft |
US20060009839A1 (en) * | 2004-07-12 | 2006-01-12 | Scimed Life Systems, Inc. | Composite vascular graft including bioactive agent coating and biodegradable sheath |
WO2006026725A2 (en) | 2004-08-31 | 2006-03-09 | C.R. Bard, Inc. | Self-sealing ptfe graft with kink resistance |
US8962023B2 (en) | 2004-09-28 | 2015-02-24 | Atrium Medical Corporation | UV cured gel and method of making |
US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US7887579B2 (en) * | 2004-09-29 | 2011-02-15 | Merit Medical Systems, Inc. | Active stent |
US7806922B2 (en) * | 2004-12-31 | 2010-10-05 | Boston Scientific Scimed, Inc. | Sintered ring supported vascular graft |
US7857843B2 (en) * | 2004-12-31 | 2010-12-28 | Boston Scientific Scimed, Inc. | Differentially expanded vascular graft |
US20060233990A1 (en) | 2005-04-13 | 2006-10-19 | Trivascular, Inc. | PTFE layers and methods of manufacturing |
US20060233991A1 (en) | 2005-04-13 | 2006-10-19 | Trivascular, Inc. | PTFE layers and methods of manufacturing |
US7731654B2 (en) * | 2005-05-13 | 2010-06-08 | Merit Medical Systems, Inc. | Delivery device with viewing window and associated method |
CA2610896C (en) * | 2005-06-17 | 2014-07-08 | C.R. Bard, Inc. | Vascular graft with kink resistance after clamping |
US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
JP5280852B2 (en) | 2005-11-09 | 2013-09-04 | シー・アール・バード・インコーポレーテッド | Grafts and stent grafts with radiopaque markers |
US7988720B2 (en) | 2006-09-12 | 2011-08-02 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
EP2079575B1 (en) | 2006-10-12 | 2021-06-02 | C.R. Bard, Inc. | Methods for making vascular grafts with multiple channels |
US7938286B2 (en) * | 2007-02-13 | 2011-05-10 | Gateway Plastics, Inc. | Container system |
US20080234809A1 (en) * | 2007-03-23 | 2008-09-25 | Medtronic Vascular, Inc. | Stent Graft System With Injection Tube |
US8721711B2 (en) * | 2007-06-20 | 2014-05-13 | Oregon Health & Science University | Graft having microporous membrane for uniform fluid infusion |
US8226701B2 (en) | 2007-09-26 | 2012-07-24 | Trivascular, Inc. | Stent and delivery system for deployment thereof |
US8663309B2 (en) | 2007-09-26 | 2014-03-04 | Trivascular, Inc. | Asymmetric stent apparatus and method |
US8066755B2 (en) | 2007-09-26 | 2011-11-29 | Trivascular, Inc. | System and method of pivoted stent deployment |
CN101917929A (en) | 2007-10-04 | 2010-12-15 | 特里瓦斯库拉尔公司 | Modular vascular graft for low profile percutaneous delivery |
US20090105811A1 (en) * | 2007-10-18 | 2009-04-23 | Medtronic, Inc. | Intravascular Devices for Cell-Based Therapies |
US8083789B2 (en) | 2007-11-16 | 2011-12-27 | Trivascular, Inc. | Securement assembly and method for expandable endovascular device |
US8328861B2 (en) | 2007-11-16 | 2012-12-11 | Trivascular, Inc. | Delivery system and method for bifurcated graft |
CA2746807A1 (en) * | 2007-12-14 | 2009-06-25 | Oregon Health & Science University | Drug delivery cuff |
US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
US8696738B2 (en) | 2010-05-20 | 2014-04-15 | Maquet Cardiovascular Llc | Composite prosthesis with external polymeric support structure and methods of manufacturing the same |
WO2012009707A2 (en) | 2010-07-16 | 2012-01-19 | Atrium Medical Corporation | Composition and methods for altering the rate of hydrolysis of cured oil-based materials |
KR101241059B1 (en) * | 2011-03-04 | 2013-03-11 | 연세대학교 산학협력단 | Device and Method for Delivery of Drug to the Exterior of Vascular Vessels using Micro-needle |
US8992595B2 (en) | 2012-04-04 | 2015-03-31 | Trivascular, Inc. | Durable stent graft with tapered struts and stable delivery methods and devices |
US9498363B2 (en) | 2012-04-06 | 2016-11-22 | Trivascular, Inc. | Delivery catheter for endovascular device |
US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
WO2014164308A1 (en) * | 2013-03-13 | 2014-10-09 | Boston Scientific Scimed, Inc. | Pancreatic stent drainage system |
US9507468B2 (en) | 2013-08-30 | 2016-11-29 | Novasentis, Inc. | Electromechanical polymer-based sensor |
US10125758B2 (en) * | 2013-08-30 | 2018-11-13 | Novasentis, Inc. | Electromechanical polymer pumps |
CN110279500A (en) * | 2019-07-31 | 2019-09-27 | 乐畅医疗器械(上海)有限公司 | A kind of Inflatable medicine slow release stent |
WO2023282903A1 (en) | 2021-07-08 | 2023-01-12 | Bard Peripheral Vascular, Inc. | Prosthesis with integrated therapeutic delivery system |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3797485A (en) * | 1971-03-26 | 1974-03-19 | Alza Corp | Novel drug delivery device for administering drug into blood circulation in blood vessel |
WO1993005730A1 (en) * | 1991-09-16 | 1993-04-01 | Atrium Medical Corporation | Controlled porosity implantable primary lumen device |
WO1998023228A1 (en) * | 1996-11-25 | 1998-06-04 | Alza Corporation | Directional drug delivery stent |
US5795318A (en) * | 1993-04-30 | 1998-08-18 | Scimed Life Systems, Inc. | Method for delivering drugs to a vascular site |
US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
US5951458A (en) * | 1996-02-29 | 1999-09-14 | Scimed Life Systems, Inc. | Local application of oxidizing agents to prevent restenosis |
WO2000018331A2 (en) * | 1998-09-29 | 2000-04-06 | C. R. Bard, Inc. | Drug delivery systems |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6037734B2 (en) | 1978-10-12 | 1985-08-28 | 住友電気工業株式会社 | Tubular organ prosthesis material and its manufacturing method |
US5156620A (en) | 1991-02-04 | 1992-10-20 | Pigott John P | Intraluminal graft/stent and balloon catheter for insertion thereof |
US5411550A (en) | 1991-09-16 | 1995-05-02 | Atrium Medical Corporation | Implantable prosthetic device for the delivery of a bioactive material |
US5197976A (en) | 1991-09-16 | 1993-03-30 | Atrium Medical Corporation | Manually separable multi-lumen vascular graft |
US5192310A (en) | 1991-09-16 | 1993-03-09 | Atrium Medical Corporation | Self-sealing implantable vascular graft |
US5716395A (en) | 1992-12-11 | 1998-02-10 | W.L. Gore & Associates, Inc. | Prosthetic vascular graft |
US5399352A (en) | 1993-04-14 | 1995-03-21 | Emory University | Device for local drug delivery and methods for using the same |
US5609624A (en) * | 1993-10-08 | 1997-03-11 | Impra, Inc. | Reinforced vascular graft and method of making same |
WO1995010989A1 (en) | 1993-10-19 | 1995-04-27 | Scimed Life Systems, Inc. | Intravascular stent pump |
JPH07255756A (en) * | 1994-03-18 | 1995-10-09 | Jinkou Ketsukan Gijutsu Kenkyu Center:Kk | Antithrombus artificial blood vessel |
US5556426A (en) | 1994-08-02 | 1996-09-17 | Meadox Medicals, Inc. | PTFE implantable tubular prostheses with external coil support |
DE69524501T2 (en) | 1994-08-12 | 2002-05-29 | Meadox Medicals Inc | Vascular graft impregnated with a heparin-containing collagen sealant |
US5665114A (en) | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
ATE202971T1 (en) | 1994-09-23 | 2001-07-15 | Impra Inc | CARBON VASCULAR TRANSPLANT AND PRODUCTION METHOD |
US6053943A (en) * | 1995-12-08 | 2000-04-25 | Impra, Inc. | Endoluminal graft with integral structural support and method for making same |
WO1996040001A1 (en) * | 1995-06-07 | 1996-12-19 | Baxter International Inc. | Externally supported tape reinforced vascular graft |
US5865723A (en) | 1995-12-29 | 1999-02-02 | Ramus Medical Technologies | Method and apparatus for forming vascular prostheses |
US5800512A (en) | 1996-01-22 | 1998-09-01 | Meadox Medicals, Inc. | PTFE vascular graft |
US5871537A (en) * | 1996-02-13 | 1999-02-16 | Scimed Life Systems, Inc. | Endovascular apparatus |
US5607478A (en) | 1996-03-14 | 1997-03-04 | Meadox Medicals Inc. | Yarn wrapped PTFE tubular prosthesis |
US6162244A (en) * | 1996-03-29 | 2000-12-19 | Willy Ruesch Ag | Layered stent |
US5849036A (en) | 1996-03-29 | 1998-12-15 | Zarate; Alfredo R. | Vascular graft prosthesis |
US5833651A (en) | 1996-11-08 | 1998-11-10 | Medtronic, Inc. | Therapeutic intraluminal stents |
US6214042B1 (en) * | 1998-11-10 | 2001-04-10 | Precision Vascular Systems, Inc. | Micro-machined stent for vessels, body ducts and the like |
US6355063B1 (en) | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
-
2000
- 2000-01-20 US US09/488,625 patent/US6355063B1/en not_active Expired - Lifetime
- 2000-12-19 ES ES07000411.4T patent/ES2642111T3/en not_active Expired - Lifetime
- 2000-12-19 DE DE60035404T patent/DE60035404T2/en not_active Expired - Lifetime
- 2000-12-19 ES ES10184299.5T patent/ES2550807T3/en not_active Expired - Lifetime
- 2000-12-19 EP EP10184299.5A patent/EP2301592B1/en not_active Expired - Lifetime
- 2000-12-19 EP EP07000411.4A patent/EP1767229B1/en not_active Expired - Lifetime
- 2000-12-19 ES ES00127283T patent/ES2288462T3/en not_active Expired - Lifetime
- 2000-12-19 EP EP00127283A patent/EP1121945B1/en not_active Expired - Lifetime
-
2001
- 2001-01-18 JP JP2001552961A patent/JP4969752B2/en not_active Expired - Lifetime
- 2001-01-18 MX MXPA02007107A patent/MXPA02007107A/en not_active Application Discontinuation
- 2001-01-18 WO PCT/US2001/002061 patent/WO2001052914A1/en active Application Filing
- 2001-01-18 CA CA2397654A patent/CA2397654C/en not_active Expired - Lifetime
-
2002
- 2002-01-31 US US10/062,788 patent/US20020091440A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3797485A (en) * | 1971-03-26 | 1974-03-19 | Alza Corp | Novel drug delivery device for administering drug into blood circulation in blood vessel |
WO1993005730A1 (en) * | 1991-09-16 | 1993-04-01 | Atrium Medical Corporation | Controlled porosity implantable primary lumen device |
US5795318A (en) * | 1993-04-30 | 1998-08-18 | Scimed Life Systems, Inc. | Method for delivering drugs to a vascular site |
US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
US5951458A (en) * | 1996-02-29 | 1999-09-14 | Scimed Life Systems, Inc. | Local application of oxidizing agents to prevent restenosis |
WO1998023228A1 (en) * | 1996-11-25 | 1998-06-04 | Alza Corporation | Directional drug delivery stent |
WO2000018331A2 (en) * | 1998-09-29 | 2000-04-06 | C. R. Bard, Inc. | Drug delivery systems |
Non-Patent Citations (1)
Title |
---|
"DIRECTIONS FOR USE", ANNOUNCEMENT IMPRA,XX,XX, 1998, pages COMPLETE, XP000945424 * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10548750B2 (en) | 1998-02-09 | 2020-02-04 | Trivascular, Inc. | Endovascular graft |
US9867727B2 (en) | 1998-02-09 | 2018-01-16 | Trivascular, Inc. | Endovascular graft |
US6936072B2 (en) | 1999-08-18 | 2005-08-30 | Intrinsic Therapeutics, Inc. | Encapsulated intervertebral disc prosthesis and methods of manufacture |
US9706947B2 (en) | 1999-08-18 | 2017-07-18 | Intrinsic Therapeutics, Inc. | Method of performing an anchor implantation procedure within a disc |
US9333087B2 (en) | 1999-08-18 | 2016-05-10 | Intrinsic Therapeutics, Inc. | Herniated disc repair |
US6355063B1 (en) | 2000-01-20 | 2002-03-12 | Impra, Inc. | Expanded PTFE drug delivery graft |
US6926735B2 (en) * | 2002-12-23 | 2005-08-09 | Scimed Life Systems, Inc. | Multi-lumen vascular grafts having improved self-sealing properties |
JP2007501676A (en) * | 2003-05-07 | 2007-02-01 | アリーヴァ メディカル インコーポレイテッド | Treatment of low back pain by restoring nutrient and waste exchange |
US8267989B2 (en) | 2004-01-30 | 2012-09-18 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
EP2332493A1 (en) | 2004-01-30 | 2011-06-15 | TriVascular, Inc. | Inflatable porous implants and methods for drug delivery |
US7803178B2 (en) | 2004-01-30 | 2010-09-28 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
EP1708647A4 (en) * | 2004-01-30 | 2008-09-03 | Trivascular2 Inc | Inflatable porous implants and methods for drug delivery |
EP1708647A2 (en) * | 2004-01-30 | 2006-10-11 | Boston Scientific Santa Rosa Corporation | Inflatable porous implants and methods for drug delivery |
US9039741B2 (en) | 2005-12-28 | 2015-05-26 | Intrinsic Therapeutics, Inc. | Bone anchor systems |
US9610106B2 (en) | 2005-12-28 | 2017-04-04 | Intrinsic Therapeutics, Inc. | Bone anchor systems |
US11185354B2 (en) | 2005-12-28 | 2021-11-30 | Intrinsic Therapeutics, Inc. | Bone anchor delivery systems and methods |
US10470804B2 (en) | 2005-12-28 | 2019-11-12 | Intrinsic Therapeutics, Inc. | Bone anchor delivery systems and methods |
US9226832B2 (en) | 2007-09-07 | 2016-01-05 | Intrinsic Therapeutics, Inc. | Interbody fusion material retention methods |
US10716685B2 (en) | 2007-09-07 | 2020-07-21 | Intrinsic Therapeutics, Inc. | Bone anchor delivery systems |
US10076424B2 (en) | 2007-09-07 | 2018-09-18 | Intrinsic Therapeutics, Inc. | Impaction systems |
Also Published As
Publication number | Publication date |
---|---|
EP1121945A1 (en) | 2001-08-08 |
DE60035404T2 (en) | 2008-03-06 |
CA2397654A1 (en) | 2001-07-26 |
US20020091440A1 (en) | 2002-07-11 |
EP1767229A2 (en) | 2007-03-28 |
EP1767229A3 (en) | 2011-03-30 |
US6355063B1 (en) | 2002-03-12 |
EP2301592B1 (en) | 2015-10-14 |
MXPA02007107A (en) | 2003-01-28 |
EP1767229B1 (en) | 2017-08-16 |
JP2003520106A (en) | 2003-07-02 |
JP4969752B2 (en) | 2012-07-04 |
ES2550807T3 (en) | 2015-11-12 |
EP2301592A1 (en) | 2011-03-30 |
CA2397654C (en) | 2010-03-16 |
DE60035404D1 (en) | 2007-08-16 |
EP1121945B1 (en) | 2007-07-04 |
ES2288462T3 (en) | 2008-01-16 |
ES2642111T3 (en) | 2017-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6355063B1 (en) | Expanded PTFE drug delivery graft | |
EP0604546B1 (en) | Extruded, controlled porosity implantable multi lumen device and method for making the same | |
US8808255B2 (en) | Drug delivery cuff | |
US5411550A (en) | Implantable prosthetic device for the delivery of a bioactive material | |
US5709874A (en) | Device for local drug delivery and methods for using the same | |
US6355055B1 (en) | Endovascular support device and method of use | |
JPH06205838A (en) | Prosthesis that can be percutaneously implanted in body of patient | |
CA2389591A1 (en) | Method of manufacturing a thin-layered, endovascular, polymer coated stent device | |
CN1290152A (en) | Non-thrombogenic stent jacket | |
US8721711B2 (en) | Graft having microporous membrane for uniform fluid infusion |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): CA JP MX |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2397654 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2002/007107 Country of ref document: MX |
|
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2001 552961 Kind code of ref document: A Format of ref document f/p: F |
|
122 | Ep: pct application non-entry in european phase |