WO2001067855A3 - Transgenic mice containing targeted gene disruptions - Google Patents

Transgenic mice containing targeted gene disruptions Download PDF

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Publication number
WO2001067855A3
WO2001067855A3 PCT/US2001/008664 US0108664W WO0167855A3 WO 2001067855 A3 WO2001067855 A3 WO 2001067855A3 US 0108664 W US0108664 W US 0108664W WO 0167855 A3 WO0167855 A3 WO 0167855A3
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WO
WIPO (PCT)
Prior art keywords
transgenic mice
targeted gene
mice containing
gene disruptions
containing targeted
Prior art date
Application number
PCT/US2001/008664
Other languages
French (fr)
Other versions
WO2001067855A2 (en
Inventor
Keith D Allen
Catherine Guenther
Russell Phillips
Original Assignee
Deltagen Inc
Keith D Allen
Catherine Guenther
Russell Phillips
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Keith D Allen, Catherine Guenther, Russell Phillips filed Critical Deltagen Inc
Priority to CA002402912A priority Critical patent/CA2402912A1/en
Priority to EP01918805A priority patent/EP1304920A2/en
Priority to IL15175901A priority patent/IL151759A0/en
Priority to AU2001245843A priority patent/AU2001245843A1/en
Priority to JP2001566337A priority patent/JP2004500102A/en
Publication of WO2001067855A2 publication Critical patent/WO2001067855A2/en
Publication of WO2001067855A3 publication Critical patent/WO2001067855A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in genes, which are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
PCT/US2001/008664 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions WO2001067855A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002402912A CA2402912A1 (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions
EP01918805A EP1304920A2 (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions
IL15175901A IL151759A0 (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions
AU2001245843A AU2001245843A1 (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions
JP2001566337A JP2004500102A (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions

Applications Claiming Priority (36)

Application Number Priority Date Filing Date Title
US19034800P 2000-03-16 2000-03-16
US60/190,348 2000-03-16
US19112800P 2000-03-22 2000-03-22
US19123600P 2000-03-22 2000-03-22
US19123500P 2000-03-22 2000-03-22
US19112900P 2000-03-22 2000-03-22
US19114200P 2000-03-22 2000-03-22
US19124000P 2000-03-22 2000-03-22
US60/191,129 2000-03-22
US60/191,142 2000-03-22
US60/191,240 2000-03-22
US60/191,128 2000-03-22
US60/191,235 2000-03-22
US60/191,236 2000-03-22
US20422700P 2000-05-15 2000-05-15
US20423000P 2000-05-15 2000-05-15
US60/204,230 2000-05-15
US60/204,227 2000-05-15
US21521400P 2000-06-29 2000-06-29
US60/215,214 2000-06-29
US21624900P 2000-07-06 2000-07-06
US21626400P 2000-07-06 2000-07-06
US21676500P 2000-07-06 2000-07-06
US60/216,765 2000-07-06
US60/216,264 2000-07-06
US60/216,249 2000-07-06
US21807500P 2000-07-12 2000-07-12
US60/218,075 2000-07-12
US21916700P 2000-07-19 2000-07-19
US21918200P 2000-07-19 2000-07-19
US60/219,182 2000-07-19
US60/219,167 2000-07-19
US22148500P 2000-07-27 2000-07-27
US60/221,485 2000-07-27
US22317300P 2000-08-07 2000-08-07
US60/223,173 2000-08-07

Publications (2)

Publication Number Publication Date
WO2001067855A2 WO2001067855A2 (en) 2001-09-20
WO2001067855A3 true WO2001067855A3 (en) 2003-02-13

Family

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Application Number Title Priority Date Filing Date
PCT/US2001/008664 WO2001067855A2 (en) 2000-03-16 2001-03-16 Transgenic mice containing targeted gene disruptions

Country Status (6)

Country Link
EP (1) EP1304920A2 (en)
JP (1) JP2004500102A (en)
AU (1) AU2001245843A1 (en)
CA (1) CA2402912A1 (en)
IL (1) IL151759A0 (en)
WO (1) WO2001067855A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000260840A1 (en) * 2000-07-11 2002-01-21 Deltagen, Inc. Methods of creating constructs useful for introducing sequences into embryonic stem cells
US20020116729A1 (en) * 2000-12-06 2002-08-22 Allen Keith D. Transgenic mice containing NTTP1 phosphatase gene disruptions
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1994026100A1 (en) * 1993-05-18 1994-11-24 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
WO1999029725A1 (en) * 1997-12-12 1999-06-17 Merck & Co., Inc. DNA MOLECULES ENCODING HUMAN NUCLEAR RECEPTOR PROTEIN, nNR5
WO2000008052A1 (en) * 1998-08-07 2000-02-17 Tularik Inc. A novel retinal nuclear hormone receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026100A1 (en) * 1993-05-18 1994-11-24 Institut National De La Sante Et De La Recherche Medicale Genetically engineered mice containing alterations in the genes encoding retinoic acid receptor proteins
WO1999029725A1 (en) * 1997-12-12 1999-06-17 Merck & Co., Inc. DNA MOLECULES ENCODING HUMAN NUCLEAR RECEPTOR PROTEIN, nNR5
WO2000008052A1 (en) * 1998-08-07 2000-02-17 Tularik Inc. A novel retinal nuclear hormone receptor

Non-Patent Citations (5)

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Title
AKHMEDOV N B ET AL: "A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 9 MAY 2000, vol. 97, no. 10, 9 May 2000 (2000-05-09), pages 5551 - 5556, XP002203637, ISSN: 0027-8424 *
CHEN FANG ET AL: "Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Muller glial cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 96, no. 26, 21 December 1999 (1999-12-21), Dec. 21, 1999, pages 15149 - 15154, XP002203636, ISSN: 0027-8424 *
HAIDER NEENA B ET AL: "Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice.", HUMAN MOLECULAR GENETICS, vol. 10, no. 16, 2001, pages 1619 - 1626, XP002203638, ISSN: 0964-6906 *
HAIDER NEENA B ET AL: "Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.", NATURE GENETICS, vol. 24, no. 2, February 2000 (2000-02-01), pages 127 - 131, XP002203635, ISSN: 1061-4036 *
KOBAYASHI M ET AL: "IDENTIFICATION OF A PHOTORECEPTOR CELL-SPECIFIC NUCLEAR RECEPTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, April 1999 (1999-04-01), pages 4814 - 4819, XP002927708, ISSN: 0027-8424 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation

Also Published As

Publication number Publication date
EP1304920A2 (en) 2003-05-02
AU2001245843A1 (en) 2001-09-24
IL151759A0 (en) 2003-04-10
JP2004500102A (en) 2004-01-08
WO2001067855A2 (en) 2001-09-20
CA2402912A1 (en) 2001-09-20

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