WO2001098508A3 - Transgenic mice containing targeted gene disruptions - Google Patents

Transgenic mice containing targeted gene disruptions Download PDF

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Publication number
WO2001098508A3
WO2001098508A3 PCT/US2001/020015 US0120015W WO0198508A3 WO 2001098508 A3 WO2001098508 A3 WO 2001098508A3 US 0120015 W US0120015 W US 0120015W WO 0198508 A3 WO0198508 A3 WO 0198508A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
transgenic mice
targeted gene
mice containing
gene disruptions
Prior art date
Application number
PCT/US2001/020015
Other languages
French (fr)
Other versions
WO2001098508A2 (en
Inventor
Thomas J Brennan
Michael W Leviten
Robert Klein
William Matthews
Mark Moore
Original Assignee
Deltagen Inc
Thomas J Brennan
Michael W Leviten
Robert Klein
William Matthews
Mark Moore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc, Thomas J Brennan, Michael W Leviten, Robert Klein, William Matthews, Mark Moore filed Critical Deltagen Inc
Priority to JP2002504656A priority Critical patent/JP2004517605A/en
Priority to EP01967934A priority patent/EP1365645A2/en
Priority to AU2001288214A priority patent/AU2001288214A1/en
Priority to CA002411978A priority patent/CA2411978A1/en
Publication of WO2001098508A2 publication Critical patent/WO2001098508A2/en
Publication of WO2001098508A3 publication Critical patent/WO2001098508A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a platelet activating receptor gene, a platelet activating factor receptor gene, an LPR5 gene or a cerberus gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
PCT/US2001/020015 2000-06-21 2001-06-21 Transgenic mice containing targeted gene disruptions WO2001098508A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002504656A JP2004517605A (en) 2000-06-21 2001-06-21 Transgenic mice containing targeted gene disruptions
EP01967934A EP1365645A2 (en) 2000-06-21 2001-06-21 Transgenic mice containing targeted gene disruptions
AU2001288214A AU2001288214A1 (en) 2000-06-21 2001-06-21 Transgenic mice containing targeted gene disruptions
CA002411978A CA2411978A1 (en) 2000-06-21 2001-06-21 Transgenic mice containing targeted gene disruptions

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US21367100P 2000-06-21 2000-06-21
US21367000P 2000-06-21 2000-06-21
US21319000P 2000-06-21 2000-06-21
US21320100P 2000-06-21 2000-06-21
US21402800P 2000-06-21 2000-06-21
US60/213,671 2000-06-21
US60/213,670 2000-06-21
US60/213,190 2000-06-21
US60/213,201 2000-06-21
US60/214,028 2000-06-21
US22312300P 2000-08-07 2000-08-07
US60/223,123 2000-08-07
US26604601P 2001-02-01 2001-02-01
US60/266,046 2001-02-01
US28070501P 2001-03-29 2001-03-29
US60/280,705 2001-03-29
US28266801P 2001-04-09 2001-04-09
US28270101P 2001-04-09 2001-04-09
US60/282,701 2001-04-09
US60/282,668 2001-04-09

Publications (2)

Publication Number Publication Date
WO2001098508A2 WO2001098508A2 (en) 2001-12-27
WO2001098508A3 true WO2001098508A3 (en) 2003-10-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020015 WO2001098508A2 (en) 2000-06-21 2001-06-21 Transgenic mice containing targeted gene disruptions

Country Status (5)

Country Link
EP (1) EP1365645A2 (en)
JP (1) JP2004517605A (en)
AU (1) AU2001288214A1 (en)
CA (1) CA2411978A1 (en)
WO (1) WO2001098508A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002599A2 (en) * 2000-06-30 2002-01-10 Ingenium Pharmaceuticals Ag HUMAN G PROTEIN-COUPLED RECEPTOR IGPcR17, AND USES THEROF
US7514594B2 (en) 2001-05-11 2009-04-07 Wyeth Transgenic animal model of bone mass modulation
EP1483288A4 (en) * 2001-05-11 2005-09-21 Genome Therapeutics Corp Hbm variants that modulate bone mass and lipid levels
JPWO2004074483A1 (en) * 2003-02-20 2006-06-01 哲哉 野阪 TSG gene knockout animal
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US9675796B2 (en) 2013-11-10 2017-06-13 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALBERTS B ET AL.: "MOLECULAR BIOLOGY OF THE CELL, THIRD EDITION", 1994, MOLECULAR BIOLOGY OF THE CELL, NEW YORK, GARLAND PUBLISHING, US, PAGE(S) 329-330, ISBN: 0-8153-1620-8, XP002227010 *
ISHII SATOSHI ET AL: "Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor.", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 11, 1 June 1998 (1998-06-01), pages 1779 - 1788, XP002227009, ISSN: 0022-1007 *
M BUY, TRANSGENIC ANIMALS, 1997, pages 1 - 4, XP002227011, Retrieved from the Internet <URL:www.ucalgary.ca/ browder/transgenic.html> [retrieved on 20030211] *
MARCHESE ADRIANO ET AL: "Novel GPCRs and their endogenous ligands: Expanding the boundaries of physiology and pharmacology", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 20, no. 9, 1999, pages 370 - 375, XP002187420, ISSN: 0165-6147 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US8958881B2 (en) 2005-08-19 2015-02-17 Brainsgate Ltd. Neuroprotective electrical stimulation

Also Published As

Publication number Publication date
EP1365645A2 (en) 2003-12-03
CA2411978A1 (en) 2001-12-27
JP2004517605A (en) 2004-06-17
WO2001098508A2 (en) 2001-12-27
AU2001288214A1 (en) 2002-01-02

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