WO2002012437A2 - Production of humanized antibodies in transgenic animals - Google Patents
Production of humanized antibodies in transgenic animals Download PDFInfo
- Publication number
- WO2002012437A2 WO2002012437A2 PCT/US2001/024348 US0124348W WO0212437A2 WO 2002012437 A2 WO2002012437 A2 WO 2002012437A2 US 0124348 W US0124348 W US 0124348W WO 0212437 A2 WO0212437 A2 WO 0212437A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- human
- humanized
- gene
- transgenic
- animal
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0273—Cloned animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/30—Bird
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Wood Science & Technology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL15475101A IL154751A0 (en) | 2000-08-03 | 2001-08-03 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals |
EA200300233A EA007958B1 (en) | 2000-08-03 | 2001-08-03 | TRANSGENIC VECTOR COMPRISING HUMANIZED Ig LOCUS AND USE THEREOF FOR PRODUCING TRANSGENIC ANIMALS |
NZ524523A NZ524523A (en) | 2000-08-03 | 2001-08-03 | Production of humanized antibodies in transgenic animals |
AU8470301A AU8470301A (en) | 2000-08-03 | 2001-08-03 | Production of humanized antibodies in transgenic animals |
AU2001284703A AU2001284703B2 (en) | 2000-08-03 | 2001-08-03 | Production of humanized antibodies in transgenic animals |
MXPA03001915A MXPA03001915A (en) | 2000-08-03 | 2001-08-03 | Production of humanized antibodies in transgenic animals. |
CA002422155A CA2422155A1 (en) | 2000-08-03 | 2001-08-03 | Production of humanized antibodies in transgenic animals |
EP01963780A EP1311530A4 (en) | 2000-08-03 | 2001-08-03 | Production of humanized antibodies in transgenic animals |
APAP/P/2003/002756A AP2003002756A0 (en) | 2000-08-03 | 2003-03-04 | Production of humanized antibodies in transgenic animals. |
IL154751A IL154751A (en) | 2000-08-03 | 2003-03-05 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals |
NO20031054A NO20031054L (en) | 2000-08-03 | 2003-03-07 | Preparation of humanized antibodies in transgenic animals |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22287200P | 2000-08-03 | 2000-08-03 | |
US60/222,872 | 2000-08-03 | ||
US27615601P | 2001-03-15 | 2001-03-15 | |
US60/276,156 | 2001-03-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002012437A2 true WO2002012437A2 (en) | 2002-02-14 |
WO2002012437A3 WO2002012437A3 (en) | 2002-05-30 |
Family
ID=26917236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/024348 WO2002012437A2 (en) | 2000-08-03 | 2001-08-03 | Production of humanized antibodies in transgenic animals |
Country Status (12)
Country | Link |
---|---|
US (2) | US7129084B2 (en) |
EP (2) | EP2044839A3 (en) |
CN (1) | CN1468250A (en) |
AP (1) | AP2003002756A0 (en) |
AU (2) | AU2001284703B2 (en) |
CA (2) | CA2422155A1 (en) |
EA (2) | EA007958B1 (en) |
IL (2) | IL154751A0 (en) |
MX (1) | MXPA03001915A (en) |
NO (1) | NO20031054L (en) |
NZ (1) | NZ524523A (en) |
WO (1) | WO2002012437A2 (en) |
Cited By (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004035607A3 (en) * | 2002-10-17 | 2004-08-12 | Genmab As | Human monoclonal antibodies against cd20 |
WO2004072115A2 (en) * | 2003-02-05 | 2004-08-26 | Therapeutic Human Polyclonals, Inc. | Suppression of endogenous immunoglobulin expression in transgenic non-human animals expressing humanized or human antibodies |
EP1476538A2 (en) * | 2002-02-01 | 2004-11-17 | Origen Therapeutics | Chimeric bird from embryonic stem cells |
WO2005007696A2 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
WO2005019463A1 (en) * | 2003-08-11 | 2005-03-03 | Therapeutic Human Polyclonals, Inc. | Improved transgenesis with humanized immunoglobulin loci |
EP1551453A2 (en) * | 2002-06-17 | 2005-07-13 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Specificity grafting of a murine antibody onto a human framework |
WO2006047367A2 (en) * | 2004-10-22 | 2006-05-04 | Therapeutic Human Polyclonals, Inc. | Suppression of endogenous immunoglubolin expression in non-human transgenic animals |
WO2006008548A3 (en) * | 2004-07-22 | 2006-06-01 | Univ Erasmus Medical Ct | Binding molecules |
WO2006117699A2 (en) * | 2005-04-29 | 2006-11-09 | Innate Pharma | Transgenic animals and methods of making recombinant antibodies |
US7323618B2 (en) | 2002-02-01 | 2008-01-29 | Origen Therapeutics, Inc. | Tissue specific expression of exogenous proteins in transgenic chickens |
US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
WO2007096779A3 (en) * | 2006-01-25 | 2008-06-26 | Univ Erasmus Medical Ct | Generation of heavy-chain only antibodies in transgenic animals |
WO2008145140A2 (en) * | 2007-05-31 | 2008-12-04 | Genmab A/S | Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals |
WO2008035216A3 (en) * | 2006-09-18 | 2009-05-14 | Univ Erasmus Medical Ct | Generation of heavy-chain only antibodies in transgenic animals |
US7541150B2 (en) | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
US20100212035A1 (en) * | 2007-06-01 | 2010-08-19 | Omt, Inc. | Compositions and Methods for Producing Transgenic Mammals Having Recombinant Immunoglobulin Loci |
US7807863B2 (en) | 2002-11-08 | 2010-10-05 | Kyowa Hakko Kirin Co., Ltd. | Transgenic bovine having reduced prion protein activity and uses thereof |
US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
US7919672B2 (en) * | 2005-08-03 | 2011-04-05 | Therapeutic Human Polyclonals, Inc. | Suppression of B-cell apoptosis in transgenic animals expressing humanized immunoglobulin |
US7928285B2 (en) | 2004-04-22 | 2011-04-19 | Kyowa Hakko Kirin Co., Ltd. | Method of producing xenogenous antibodies using a bovine |
EP2386573A1 (en) | 2006-11-24 | 2011-11-16 | Agricultural Biotechnology Center | Transgenic animal with enhanced immune response and method for the preparation thereof |
WO2012018610A2 (en) | 2010-07-26 | 2012-02-09 | Trianni, Inc. | Transgenic animals and methods of use |
US8502014B2 (en) | 2001-04-24 | 2013-08-06 | Erasmus Universiteit Rotterdam | Method for the production of a single heavy chain antibody |
US8592644B2 (en) | 2009-08-13 | 2013-11-26 | Crystal Bioscience Inc. | Transgenic animal for production of antibodies having minimal CDRS |
US20140017238A1 (en) | 2001-02-16 | 2014-01-16 | Regeneron Pharmaceuticals, Inc. | Methods of Modifying Eukaryotic Cells |
US8865462B2 (en) | 2010-01-20 | 2014-10-21 | Crystal Bioscience Inc. | Sustained culture of avian gonocytes |
US9144229B2 (en) | 2002-02-01 | 2015-09-29 | Synageva Biopharma Corp. | Tissue specific expression of antibodies in chickens |
US9260517B2 (en) | 2009-11-17 | 2016-02-16 | Musc Foundation For Research Development | Human monoclonal antibodies to human nucleolin |
US9346873B2 (en) | 2008-09-30 | 2016-05-24 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
US9439405B2 (en) | 2001-06-21 | 2016-09-13 | Crescendo Biologics Limited | Mouse λ light chain locus |
US9452219B2 (en) | 2011-06-02 | 2016-09-27 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles |
US9476027B2 (en) | 2006-09-01 | 2016-10-25 | Roche Diagnostics Gmbh | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
US9516868B2 (en) | 2010-08-02 | 2016-12-13 | Regeneron Pharmaceuticals, Inc. | Mice that make VL binding proteins |
US9528124B2 (en) | 2013-08-27 | 2016-12-27 | Recombinetics, Inc. | Efficient non-meiotic allele introgression |
WO2017072208A1 (en) * | 2015-10-29 | 2017-05-04 | F. Hoffmann-La Roche Ag | Transgenic rabbit with common light chain |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US9888675B2 (en) | 2009-12-10 | 2018-02-13 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
US9932398B2 (en) | 2011-10-17 | 2018-04-03 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
US9930871B2 (en) | 2013-02-20 | 2018-04-03 | Regeneron Pharmaceuticals, Inc. | Non-human animals with modified immunoglobulin heavy chain sequences |
US9969814B2 (en) | 2010-02-08 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | Methods for making fully human bispecific antibodies using a common light chain |
US10130081B2 (en) | 2011-08-05 | 2018-11-20 | Regeneron Pharmaceuticals, Inc. | Humanized universal light chain mice |
US10143186B2 (en) | 2010-02-08 | 2018-12-04 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
WO2019129679A1 (en) | 2017-12-29 | 2019-07-04 | F. Hoffmann-La Roche Ag | Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody |
US10344299B2 (en) | 2000-10-31 | 2019-07-09 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for modifying cells |
US10494445B2 (en) | 2010-03-31 | 2019-12-03 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10730943B2 (en) | 2013-09-16 | 2020-08-04 | Helmholtz Zentrum München-Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | Means and methods for treating HBV infection and associated conditions |
US10787522B2 (en) | 2014-03-21 | 2020-09-29 | Regeneron Pharmaceuticals, Inc. | VL antigen binding proteins exhibiting distinct binding characteristics |
US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
US10813346B2 (en) | 2015-12-03 | 2020-10-27 | Trianni, Inc. | Enhanced immunoglobulin diversity |
US10857237B2 (en) | 2015-05-05 | 2020-12-08 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and MRI and/or X-ray contrast agents |
WO2020260326A1 (en) | 2019-06-27 | 2020-12-30 | F. Hoffmann-La Roche Ag | Novel icos antibodies and tumor-targeted antigen binding molecules comprising them |
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US10893667B2 (en) | 2011-02-25 | 2021-01-19 | Recombinetics, Inc. | Non-meiotic allele introgression |
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US11053288B2 (en) | 2016-02-04 | 2021-07-06 | Trianni, Inc. | Enhanced production of immunoglobulins |
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ES2378407T3 (en) | 2006-09-01 | 2012-04-12 | Therapeutic Human Polyclonals, Inc. | Increased expression of human or humanized immunoglobulin in non-human transgenic animals |
EP2068928A2 (en) * | 2006-09-28 | 2009-06-17 | Merck Serono SA | Junctional adhesion molecule-c (jam-c) binding compounds and methods of their use |
EP1970384A1 (en) | 2007-03-14 | 2008-09-17 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
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NO20031054D0 (en) | 2003-03-07 |
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CN1468250A (en) | 2004-01-14 |
EP2044839A2 (en) | 2009-04-08 |
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US7129084B2 (en) | 2006-10-31 |
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