WO2002024107A3 - Fabrication of thin sheet bio-artificial organs - Google Patents

Fabrication of thin sheet bio-artificial organs Download PDF

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Publication number
WO2002024107A3
WO2002024107A3 PCT/US2001/029586 US0129586W WO0224107A3 WO 2002024107 A3 WO2002024107 A3 WO 2002024107A3 US 0129586 W US0129586 W US 0129586W WO 0224107 A3 WO0224107 A3 WO 0224107A3
Authority
WO
WIPO (PCT)
Prior art keywords
linked
fabrication
forming
cross
thin sheet
Prior art date
Application number
PCT/US2001/029586
Other languages
French (fr)
Other versions
WO2002024107A2 (en
Inventor
Randel Dorian
Scott King
Richard Wood Storrs
Original Assignee
Islet Sheet Medical Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Islet Sheet Medical Llc filed Critical Islet Sheet Medical Llc
Priority to AU9118201A priority Critical patent/AU9118201A/en
Priority to CA002421036A priority patent/CA2421036A1/en
Publication of WO2002024107A2 publication Critical patent/WO2002024107A2/en
Publication of WO2002024107A3 publication Critical patent/WO2002024107A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells

Abstract

In one embodiment of the present invention, a method is provided for making a physiologically active and biocompatible cellular implant for implantation into a host body. The method includes the steps of: (a) forming first and second layers of first and second polymer solutions, respectively, each layer having a first substantially uncross-linked surface and an opposing second cross-linked surface; (b) forming a sandwich of a cell suspension layer of physiologically active cells in a substantially uncross-linked third solution between the first and second, and (c) cross-linking the first and second polymer solutions in a direction toward the cell suspension layer, thereby forming a cellular implant. In another embodiment, all polymer solutions initially are uncross-linked and sequentially spread in layers followed by cross-linking.
PCT/US2001/029586 2000-09-20 2001-09-19 Fabrication of thin sheet bio-artificial organs WO2002024107A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU9118201A AU9118201A (en) 2000-09-20 2001-09-19 Improved methods for fabrication of thin sheet bio-artificial organs
CA002421036A CA2421036A1 (en) 2000-09-20 2001-09-19 Fabrication of thin sheet bio-artificial organs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66548500A 2000-09-20 2000-09-20
US09/665,485 2000-09-20

Publications (2)

Publication Number Publication Date
WO2002024107A2 WO2002024107A2 (en) 2002-03-28
WO2002024107A3 true WO2002024107A3 (en) 2002-07-04

Family

ID=24670294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/029586 WO2002024107A2 (en) 2000-09-20 2001-09-19 Fabrication of thin sheet bio-artificial organs

Country Status (3)

Country Link
AU (1) AU9118201A (en)
CA (1) CA2421036A1 (en)
WO (1) WO2002024107A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
DE602004029928D1 (en) 2003-12-23 2010-12-16 Fmc Biopolymer As USE OF ALGINATE MATRICES FOR CONTROLLING CELL GROWTH
WO2009111338A1 (en) 2008-02-29 2009-09-11 Biomet Manufacturing Corp. A system and process for separating a material
US9540630B2 (en) 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
WO2011154941A2 (en) 2010-06-07 2011-12-15 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US20170304528A1 (en) * 2016-04-22 2017-10-26 DeepScience Ltd. Implantable medical device for delivering cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855613A (en) * 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5976780A (en) * 1996-07-16 1999-11-02 Shah; Kumarpal A. Encapsulated cell device

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459054A (en) 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
IL102785A (en) 1991-08-20 1998-06-15 Univ Leicester Method for removing protein from a water- soluble gum and a method of making biocompatible capsules using said gum
US5429821A (en) 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
WO1994013266A1 (en) 1992-05-29 1994-06-23 The Regents Of The University Of California Novel electrostatic process for manufacturing coated transplants and products
US5578314A (en) 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
US5643594A (en) 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
JPH09512015A (en) 1994-04-13 1997-12-02 リサーチ・コーポレイション・テクノロジーズ・インコーポレイテッド Method for treating disease using Sertoli cells and allograft or xenograft

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5855613A (en) * 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5976780A (en) * 1996-07-16 1999-11-02 Shah; Kumarpal A. Encapsulated cell device

Also Published As

Publication number Publication date
WO2002024107A2 (en) 2002-03-28
AU9118201A (en) 2002-04-02
CA2421036A1 (en) 2002-03-28

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