WO2002042735A3 - Human kcr1 regulation of herg potassium channel block - Google Patents

Human kcr1 regulation of herg potassium channel block Download PDF

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Publication number
WO2002042735A3
WO2002042735A3 PCT/US2001/045644 US0145644W WO0242735A3 WO 2002042735 A3 WO2002042735 A3 WO 2002042735A3 US 0145644 W US0145644 W US 0145644W WO 0242735 A3 WO0242735 A3 WO 0242735A3
Authority
WO
WIPO (PCT)
Prior art keywords
kcr1
potassium channel
methods
regulation
human
Prior art date
Application number
PCT/US2001/045644
Other languages
French (fr)
Other versions
WO2002042735A9 (en
WO2002042735A2 (en
Inventor
Jeffrey R Balser
Alfred L George Jr
Dan M Roden
Original Assignee
Vanderbuilt University
Jeffrey R Balser
Alfred L George Jr
Dan M Roden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbuilt University, Jeffrey R Balser, Alfred L George Jr, Dan M Roden filed Critical Vanderbuilt University
Priority to AU2002241555A priority Critical patent/AU2002241555A1/en
Publication of WO2002042735A2 publication Critical patent/WO2002042735A2/en
Publication of WO2002042735A9 publication Critical patent/WO2002042735A9/en
Publication of WO2002042735A3 publication Critical patent/WO2002042735A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Abstract

The present invention discloses methods relating to screening methods and methods of identifying a compound that can modulate HERG potassium channel activity. The methods generally employ at least HERG and KCR1 polypeptides. The disclosed methods can be applied in the development of a candidate pharmaceutical or they can be employed to evaluate presently marketed pharmaceuticals.
PCT/US2001/045644 2000-10-30 2001-10-30 Human kcr1 regulation of herg potassium channel block WO2002042735A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002241555A AU2002241555A1 (en) 2000-10-30 2001-10-30 Human kcr1 regulation of herg potassium channel block

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24434000P 2000-10-30 2000-10-30
US60/244,340 2000-10-30

Publications (3)

Publication Number Publication Date
WO2002042735A2 WO2002042735A2 (en) 2002-05-30
WO2002042735A9 WO2002042735A9 (en) 2003-02-06
WO2002042735A3 true WO2002042735A3 (en) 2004-05-06

Family

ID=22922326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045644 WO2002042735A2 (en) 2000-10-30 2001-10-30 Human kcr1 regulation of herg potassium channel block

Country Status (3)

Country Link
US (1) US20030013136A1 (en)
AU (1) AU2002241555A1 (en)
WO (1) WO2002042735A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1440256A (en) * 2000-05-08 2003-09-03 布雷恩斯盖特有限公司 Method and apparatus for stimulating sphenopalatine ganglion to modify properties of BBB and cerebral blood flow
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US7117033B2 (en) * 2000-05-08 2006-10-03 Brainsgate, Ltd. Stimulation for acute conditions
US6783979B2 (en) * 2001-06-06 2004-08-31 The Trustees Of Columbia University In The City Of New York Research Foundation Of State University Of New York Vectors encoding HCN channels and MiRP1
WO2002098287A2 (en) * 2001-06-06 2002-12-12 The Trustees Of Columbia University In The City Of New York A high throughput biological heart rate monitor that is molecularly determined
IL159819A0 (en) * 2001-07-13 2004-06-20 Janssen Pharmaceutica Nv Cardiovascular safety assay
KR20050000409A (en) * 2002-04-25 2005-01-03 브레인스게이트 리미티드 Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head
US7684859B2 (en) * 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
US7561919B2 (en) * 2002-11-14 2009-07-14 Brainsgate Ltd. SPG stimulation via the greater palatine canal
JP2006515999A (en) * 2002-11-14 2006-06-15 ブレインズゲート リミティド Surgical tools and techniques for stimulation
ATE415959T1 (en) * 2003-09-04 2008-12-15 Neurosearch As HERG1 CHANNEL OPENER FOR THE TREATMENT OF HEART ARRYTHMIA
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US8010189B2 (en) 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
US20090299418A1 (en) * 2004-08-23 2009-12-03 Brainsgate Ltd. Concurrent bilateral spg modulation
AU2005316270A1 (en) * 2004-12-16 2006-06-22 Novascreen Biosciences A method for identification and functional characterization of agents which modulate ion channel activity
US7396524B2 (en) * 2005-08-02 2008-07-08 Main Line Health Heart Center Methods for screening compounds for proarrhythmic risk and antiarrhythmic efficacy
US20090210026A1 (en) * 2006-08-17 2009-08-20 Brainsgate Ltd. Spg stimulation for enhancing neurogenesis and brain metabolism
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
EP2878335B1 (en) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant and delivery system for neural stimulator
EP3093043B1 (en) 2015-05-13 2018-11-14 Brainsgate Ltd. Implant and delivery system for neural stimulator

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SANGUINETTI M.C. ET AL.: "Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia", PROC. NATL. ACAD. SCI. USA, vol. 93, March 1996 (1996-03-01), pages 2208 - 2212, XP002974220 *

Also Published As

Publication number Publication date
AU2002241555A1 (en) 2002-06-03
US20030013136A1 (en) 2003-01-16
WO2002042735A9 (en) 2003-02-06
WO2002042735A2 (en) 2002-05-30

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