WO2002047665A3 - Methods and compositions for encapsulating active agents - Google Patents

Methods and compositions for encapsulating active agents Download PDF

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Publication number
WO2002047665A3
WO2002047665A3 PCT/US2001/046181 US0146181W WO0247665A3 WO 2002047665 A3 WO2002047665 A3 WO 2002047665A3 US 0146181 W US0146181 W US 0146181W WO 0247665 A3 WO0247665 A3 WO 0247665A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
colloidosomes
methods
solvent
biocompatible
Prior art date
Application number
PCT/US2001/046181
Other languages
French (fr)
Other versions
WO2002047665A2 (en
Inventor
Andreas Bausch
Anthony Dinsmore
Ming Hsu
Michael Nikolaides
David Weitz
Original Assignee
Harvard College
Andreas Bausch
Anthony Dinsmore
Ming Hsu
Michael Nikolaides
David Weitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Andreas Bausch, Anthony Dinsmore, Ming Hsu, Michael Nikolaides, David Weitz filed Critical Harvard College
Priority to EP01989162A priority Critical patent/EP1385488A2/en
Priority to AU2002243277A priority patent/AU2002243277A1/en
Priority to US10/433,753 priority patent/US20040096515A1/en
Publication of WO2002047665A2 publication Critical patent/WO2002047665A2/en
Publication of WO2002047665A3 publication Critical patent/WO2002047665A3/en
Priority to US12/712,620 priority patent/US20100213628A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Abstract

Methods for making self-assembled, selectively permeable elastic microscopie structures, referred to herein as colloidosomes, that have controlled pore-size, porosity and advantageous mechanical properties are described. In one form of the invention, a method of forming colloidosomes includes providing particles formed from a biocompatible material in a first solvent and forming an emulsion by adding a first fluid to the first solvent wherein the emulsion is defined by droplets of the first fluid surrounded by the first solvent. The method includes coating the surface of droplet with the particles and the stabilizing the particles on the surface of droplet. The colloidosomes produced typically have a yield strength of at least about 20 Pascals. In certain forms of the invention, the particles are spherical and are formed of a biocompatible polymer. Colloidosomes formed according to the methods described herein are also provided. In one form, a colloidosome includes a shell formed of biocompatible, substantially spherical particles wherein each of the particles are linked to neighboring particles. The shell defines an inner chamber sized for housing a desired active agent and has a plurality of pores extending therethrough. The colloidosomes are structurally stable, typically having a yield strength of at least about 20 Pascals. Colloidal suspension and methods of encapsulating a desired active agent are also described.
PCT/US2001/046181 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents WO2002047665A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01989162A EP1385488A2 (en) 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents
AU2002243277A AU2002243277A1 (en) 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents
US10/433,753 US20040096515A1 (en) 2001-12-07 2001-12-07 Methods and compositions for encapsulating active agents
US12/712,620 US20100213628A1 (en) 2000-12-07 2010-02-25 Methods and compositions for encapsulating active agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25421000P 2000-12-07 2000-12-07
US60/254,210 2000-12-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/712,620 Continuation US20100213628A1 (en) 2000-12-07 2010-02-25 Methods and compositions for encapsulating active agents

Publications (2)

Publication Number Publication Date
WO2002047665A2 WO2002047665A2 (en) 2002-06-20
WO2002047665A3 true WO2002047665A3 (en) 2003-07-24

Family

ID=22963357

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046181 WO2002047665A2 (en) 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents

Country Status (3)

Country Link
EP (1) EP1385488A2 (en)
AU (1) AU2002243277A1 (en)
WO (1) WO2002047665A2 (en)

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CN102008925B (en) * 2010-12-17 2012-11-28 天津大学 Method for preparing inorganic/organic composite microspheres
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8871444B2 (en) 2004-10-08 2014-10-28 Medical Research Council In vitro evolution in microfluidic systems
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US9228229B2 (en) 2010-02-12 2016-01-05 Raindance Technologies, Inc. Digital analyte analysis
US9273308B2 (en) 2006-05-11 2016-03-01 Raindance Technologies, Inc. Selection of compartmentalized screening method
US9328344B2 (en) 2006-01-11 2016-05-03 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9440232B2 (en) 2007-02-06 2016-09-13 Raindance Technologies, Inc. Manipulation of fluids and reactions in microfluidic systems
US9448172B2 (en) 2003-03-31 2016-09-20 Medical Research Council Selection by compartmentalised screening
US9498759B2 (en) 2004-10-12 2016-11-22 President And Fellows Of Harvard College Compartmentalized screening by microfluidic control
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets

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JP2006507921A (en) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Method and apparatus for fluid dispersion
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP1610888A2 (en) 2003-04-10 2006-01-04 President And Fellows Of Harvard College Formation and control of fluidic species
BRPI0414004A (en) 2003-08-27 2006-10-24 Harvard College electronic control of fluidic species
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
CA2599683A1 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
JP5225835B2 (en) * 2005-06-07 2013-07-03 ユニバーシティー オブ サウス オーストラリア Dry formulation of nanoparticle-coated capsule
AU2006255477B2 (en) * 2005-06-07 2012-07-05 Reformpharm Pty Ltd Dried formulations of nanoparticle-coated capsules
WO2007128066A1 (en) * 2006-05-04 2007-11-15 University Of South Australia Drug release from nanoparticle-coated capsules
CN102014871A (en) 2007-03-28 2011-04-13 哈佛大学 Emulsions and techniques for formation
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8093038B2 (en) 2007-09-17 2012-01-10 Illinois Institute Of Technology Apparatus and method for encapsulating pancreatic cells
GB0718300D0 (en) * 2007-09-20 2007-10-31 Univ Leeds Microcapsules and methods
US8778400B2 (en) 2008-04-21 2014-07-15 University Of South Australia Nanoparticle-stabilized capsule formulation for treatment of inflammation
EP2128180A1 (en) 2008-05-29 2009-12-02 Unilever N.V. Amphiphilic branched polymers and their use as emulsifiers
KR20110042050A (en) * 2008-06-05 2011-04-22 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Polymersomes, colloidosomes, liposomes, and other species associated with fluidic droplets
EP4047367A1 (en) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Method for detecting target analytes with droplet libraries
WO2010033200A2 (en) 2008-09-19 2010-03-25 President And Fellows Of Harvard College Creation of libraries of droplets and related species
EP3415235A1 (en) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation of microfluidic droplets
EP2473263B1 (en) 2009-09-02 2022-11-02 President and Fellows of Harvard College Multiple emulsions created using jetting and other techniques
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
NL2004533C2 (en) 2010-04-09 2011-10-11 Friesland Brands Bv Particle preparation by centrifugal dispersing.
CN101857700B (en) * 2010-06-21 2011-08-17 郑州大学 Method for self assembling non-spherical polystyrene grains to form into multihole and ordered structure
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
GB2491387A (en) * 2011-06-02 2012-12-05 Magnequench Ltd Rare earth material capsule used in making a magnet
EP3709018A1 (en) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Microfluidic apparatus for identifying components of a chemical reaction
WO2013006661A2 (en) 2011-07-06 2013-01-10 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015069634A1 (en) 2013-11-08 2015-05-14 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
GB201319923D0 (en) * 2013-11-12 2013-12-25 Cambridge Entpr Ltd Novel composition
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN108289797B (en) 2015-10-13 2022-01-28 哈佛学院院长及董事 Systems and methods for making and using gel microspheres

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Non-Patent Citations (4)

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Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9448172B2 (en) 2003-03-31 2016-09-20 Medical Research Council Selection by compartmentalised screening
US8871444B2 (en) 2004-10-08 2014-10-28 Medical Research Council In vitro evolution in microfluidic systems
US9186643B2 (en) 2004-10-08 2015-11-17 Medical Research Council In vitro evolution in microfluidic systems
US9498759B2 (en) 2004-10-12 2016-11-22 President And Fellows Of Harvard College Compartmentalized screening by microfluidic control
US9410151B2 (en) 2006-01-11 2016-08-09 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9534216B2 (en) 2006-01-11 2017-01-03 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9328344B2 (en) 2006-01-11 2016-05-03 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9273308B2 (en) 2006-05-11 2016-03-01 Raindance Technologies, Inc. Selection of compartmentalized screening method
US9498761B2 (en) 2006-08-07 2016-11-22 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US9440232B2 (en) 2007-02-06 2016-09-13 Raindance Technologies, Inc. Manipulation of fluids and reactions in microfluidic systems
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9228229B2 (en) 2010-02-12 2016-01-05 Raindance Technologies, Inc. Digital analyte analysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
CN102008925B (en) * 2010-12-17 2012-11-28 天津大学 Method for preparing inorganic/organic composite microspheres
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing

Also Published As

Publication number Publication date
AU2002243277A1 (en) 2002-06-24
EP1385488A2 (en) 2004-02-04
WO2002047665A2 (en) 2002-06-20

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