WO2002055058A3 - Flexible microchip devices for ophthalmic and other applications - Google Patents

Flexible microchip devices for ophthalmic and other applications Download PDF

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Publication number
WO2002055058A3
WO2002055058A3 PCT/US2002/000581 US0200581W WO02055058A3 WO 2002055058 A3 WO2002055058 A3 WO 2002055058A3 US 0200581 W US0200581 W US 0200581W WO 02055058 A3 WO02055058 A3 WO 02055058A3
Authority
WO
WIPO (PCT)
Prior art keywords
contain
ophthalmic
applications
microchip
microchip devices
Prior art date
Application number
PCT/US2002/000581
Other languages
French (fr)
Other versions
WO2002055058A2 (en
Inventor
John T Santini Jr
Michael J Cima
Robert S Langer
Dennis Ausiello
Norman F Sheppard Jr
Stephen J Herman
Original Assignee
Microchips Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc filed Critical Microchips Inc
Priority to CA2432438A priority Critical patent/CA2432438C/en
Priority to EP02707424A priority patent/EP1372602B1/en
Priority to DE60219607T priority patent/DE60219607T2/en
Priority to AU2002241834A priority patent/AU2002241834B2/en
Priority to JP2002555792A priority patent/JP4657577B2/en
Publication of WO2002055058A2 publication Critical patent/WO2002055058A2/en
Publication of WO2002055058A3 publication Critical patent/WO2002055058A3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L24/00Arrangements for connecting or disconnecting semiconductor or solid-state bodies; Methods or apparatus related thereto
    • H01L24/93Batch processes
    • H01L24/95Batch processes at chip-level, i.e. with connecting carried out on a plurality of singulated devices, i.e. on diced chips
    • H01L24/96Batch processes at chip-level, i.e. with connecting carried out on a plurality of singulated devices, i.e. on diced chips the devices being encapsulated in a common layer, e.g. neo-wafer or pseudo-wafer, said common layer being separable into individual assemblies after connecting
    • HELECTRICITY
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    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
    • H01L2924/01004Beryllium [Be]
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    • H01L2924/01005Boron [B]
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    • H01L2924/01006Carbon [C]
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    • H01L2924/01011Sodium [Na]
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    • H01L2924/01013Aluminum [Al]
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    • H01L2924/01015Phosphorus [P]
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    • H01L2924/0102Calcium [Ca]
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    • H01L2924/01027Cobalt [Co]
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    • H01L2924/01Chemical elements
    • H01L2924/01033Arsenic [As]
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    • H01L2924/01Chemical elements
    • H01L2924/01074Tungsten [W]
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    • H01L2924/01Chemical elements
    • H01L2924/01075Rhenium [Re]
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    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/01Chemical elements
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    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/013Alloys
    • H01L2924/014Solder alloys
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    • H01L2924/10Details of semiconductor or other solid state devices to be connected
    • H01L2924/11Device type
    • H01L2924/12Passive devices, e.g. 2 terminal devices
    • H01L2924/1204Optical Diode
    • H01L2924/12041LED
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    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/10Details of semiconductor or other solid state devices to be connected
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    • H01L2924/12Passive devices, e.g. 2 terminal devices
    • H01L2924/1204Optical Diode
    • H01L2924/12042LASER
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    • H01ELECTRIC ELEMENTS
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    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/10Details of semiconductor or other solid state devices to be connected
    • H01L2924/11Device type
    • H01L2924/12Passive devices, e.g. 2 terminal devices
    • H01L2924/1204Optical Diode
    • H01L2924/12043Photo diode
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    • H01L2924/10Details of semiconductor or other solid state devices to be connected
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    • H01L2924/14Integrated circuits
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    • H01L2924/10Details of semiconductor or other solid state devices to be connected
    • H01L2924/146Mixed devices
    • H01L2924/1461MEMS
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    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/19Details of hybrid assemblies other than the semiconductor or other solid state devices to be connected
    • H01L2924/1901Structure
    • H01L2924/1904Component type
    • H01L2924/19041Component type being a capacitor
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01LSEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
    • H01L2924/19Details of hybrid assemblies other than the semiconductor or other solid state devices to be connected
    • H01L2924/1901Structure
    • H01L2924/1904Component type
    • H01L2924/19043Component type being a resistor

Abstract

Microchip device arrays that can conform to a curved surface are provided for the controlled release or exposure of reservoir contents. The arrays comprise two or more microchip device elements, each of which includes a plurality of reservoirs that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices, such as a sensor or a component thereof. Preferably, the microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules to and into the eye of a patient in need thereof.
PCT/US2002/000581 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications WO2002055058A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2432438A CA2432438C (en) 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications
EP02707424A EP1372602B1 (en) 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications
DE60219607T DE60219607T2 (en) 2001-01-09 2002-01-09 FLEXIBLE MICROCHIP DEVICES FOR OPHTHALMOLOGICAL AND OTHER APPLICATION
AU2002241834A AU2002241834B2 (en) 2001-01-09 2002-01-09 Flexible microchip devices for opthalmic and other applications
JP2002555792A JP4657577B2 (en) 2001-01-09 2002-01-09 Flexible microchip device for ocular and other applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26072501P 2001-01-09 2001-01-09
US60/260,725 2001-01-09

Publications (2)

Publication Number Publication Date
WO2002055058A2 WO2002055058A2 (en) 2002-07-18
WO2002055058A3 true WO2002055058A3 (en) 2003-10-16

Family

ID=22990347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000581 WO2002055058A2 (en) 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications

Country Status (8)

Country Link
US (5) US6976982B2 (en)
EP (1) EP1372602B1 (en)
JP (3) JP4657577B2 (en)
AT (1) ATE359762T1 (en)
AU (1) AU2002241834B2 (en)
CA (1) CA2432438C (en)
DE (1) DE60219607T2 (en)
WO (1) WO2002055058A2 (en)

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