WO2002055058A3 - Flexible microchip devices for ophthalmic and other applications - Google Patents

Flexible microchip devices for ophthalmic and other applications Download PDF

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Publication number
WO2002055058A3
WO2002055058A3 PCT/US2002/000581 US0200581W WO02055058A3 WO 2002055058 A3 WO2002055058 A3 WO 2002055058A3 US 0200581 W US0200581 W US 0200581W WO 02055058 A3 WO02055058 A3 WO 02055058A3
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WO
WIPO (PCT)
Prior art keywords
contain
ophthalmic
applications
microchip
microchip devices
Prior art date
Application number
PCT/US2002/000581
Other languages
French (fr)
Other versions
WO2002055058A2 (en
Inventor
John T Santini Jr
Michael J Cima
Robert S Langer
Dennis Ausiello
Norman F Sheppard Jr
Stephen J Herman
Original Assignee
Microchips Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc filed Critical Microchips Inc
Priority to DE60219607T priority Critical patent/DE60219607T2/en
Priority to CA2432438A priority patent/CA2432438C/en
Priority to EP02707424A priority patent/EP1372602B1/en
Priority to AU2002241834A priority patent/AU2002241834B2/en
Priority to JP2002555792A priority patent/JP4657577B2/en
Publication of WO2002055058A2 publication Critical patent/WO2002055058A2/en
Publication of WO2002055058A3 publication Critical patent/WO2002055058A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L24/00—Arrangements for connecting or disconnecting semiconductor or solid-state bodies; Methods or apparatus related thereto
    • H01L24/93—Batch processes
    • H01L24/95—Batch processes at chip-level, i.e. with connecting carried out on a plurality of singulated devices, i.e. on diced chips
    • H01L24/96—Batch processes at chip-level, i.e. with connecting carried out on a plurality of singulated devices, i.e. on diced chips the devices being encapsulated in a common layer, e.g. neo-wafer or pseudo-wafer, said common layer being separable into individual assemblies after connecting
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    • H01L2924/01015—Phosphorus [P]
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    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L2924/00—Indexing scheme for arrangements or methods for connecting or disconnecting semiconductor or solid-state bodies as covered by H01L24/00
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    • H01L2924/0102—Calcium [Ca]
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    • H01L2924/01033—Arsenic [As]
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    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
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    • H01L2924/01—Chemical elements
    • H01L2924/01075—Rhenium [Re]
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    • H01L2924/01—Chemical elements
    • H01L2924/01079—Gold [Au]
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    • H01L2924/013—Alloys
    • H01L2924/014—Solder alloys
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    • H01L2924/10—Details of semiconductor or other solid state devices to be connected
    • H01L2924/11—Device type
    • H01L2924/12—Passive devices, e.g. 2 terminal devices
    • H01L2924/1204—Optical Diode
    • H01L2924/12041—LED
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    • H01L2924/1204—Optical Diode
    • H01L2924/12042—LASER
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    • H01L2924/12043—Photo diode
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    • H01L2924/10—Details of semiconductor or other solid state devices to be connected
    • H01L2924/146—Mixed devices
    • H01L2924/1461—MEMS
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    • H01L2924/19—Details of hybrid assemblies other than the semiconductor or other solid state devices to be connected
    • H01L2924/1901—Structure
    • H01L2924/1904—Component type
    • H01L2924/19041—Component type being a capacitor
    • H—ELECTRICITY
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    • H01L2924/19—Details of hybrid assemblies other than the semiconductor or other solid state devices to be connected
    • H01L2924/1901—Structure
    • H01L2924/1904—Component type
    • H01L2924/19043—Component type being a resistor

Abstract

Microchip device arrays that can conform to a curved surface are provided for the controlled release or exposure of reservoir contents. The arrays comprise two or more microchip device elements, each of which includes a plurality of reservoirs that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices, such as a sensor or a component thereof. Preferably, the microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules to and into the eye of a patient in need thereof.
PCT/US2002/000581 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications WO2002055058A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60219607T DE60219607T2 (en) 2001-01-09 2002-01-09 FLEXIBLE MICROCHIP DEVICES FOR OPHTHALMOLOGICAL AND OTHER APPLICATION
CA2432438A CA2432438C (en) 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications
EP02707424A EP1372602B1 (en) 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications
AU2002241834A AU2002241834B2 (en) 2001-01-09 2002-01-09 Flexible microchip devices for opthalmic and other applications
JP2002555792A JP4657577B2 (en) 2001-01-09 2002-01-09 Flexible microchip device for ocular and other applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26072501P 2001-01-09 2001-01-09
US60/260,725 2001-01-09

Publications (2)

Publication Number Publication Date
WO2002055058A2 WO2002055058A2 (en) 2002-07-18
WO2002055058A3 true WO2002055058A3 (en) 2003-10-16

Family

ID=22990347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000581 WO2002055058A2 (en) 2001-01-09 2002-01-09 Flexible microchip devices for ophthalmic and other applications

Country Status (8)

Country Link
US (5) US6976982B2 (en)
EP (1) EP1372602B1 (en)
JP (3) JP4657577B2 (en)
AT (1) ATE359762T1 (en)
AU (1) AU2002241834B2 (en)
CA (1) CA2432438C (en)
DE (1) DE60219607T2 (en)
WO (1) WO2002055058A2 (en)

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