WO2002059602A8 - A label-free high-throughput optical technique for detecting biomolecular interactions - Google Patents
A label-free high-throughput optical technique for detecting biomolecular interactionsInfo
- Publication number
- WO2002059602A8 WO2002059602A8 PCT/US2001/050723 US0150723W WO02059602A8 WO 2002059602 A8 WO2002059602 A8 WO 2002059602A8 US 0150723 W US0150723 W US 0150723W WO 02059602 A8 WO02059602 A8 WO 02059602A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- label
- biomolecular interactions
- free high
- optical technique
- detecting biomolecular
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4788—Diffraction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B5/00—Optical elements other than lenses
- G02B5/18—Diffraction gratings
- G02B5/1809—Diffraction gratings with pitch less than or comparable to the wavelength
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/415,037 US7435385B2 (en) | 2000-10-30 | 2001-10-23 | Label-free high-throughput optical technique for detecting biomolecular interactions |
AU2002246885A AU2002246885A1 (en) | 2000-10-30 | 2001-10-23 | A label-free high-throughput optical technique for detecting biomolecular interactions |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24431200P | 2000-10-30 | 2000-10-30 | |
US60/244,312 | 2000-10-30 | ||
US28331401P | 2001-04-12 | 2001-04-12 | |
US60/283,314 | 2001-04-12 | ||
US30302801P | 2001-07-03 | 2001-07-03 | |
US60/303,028 | 2001-07-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002059602A2 WO2002059602A2 (en) | 2002-08-01 |
WO2002059602A3 WO2002059602A3 (en) | 2003-01-30 |
WO2002059602A8 true WO2002059602A8 (en) | 2003-03-20 |
Family
ID=27399745
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/050723 WO2002059602A2 (en) | 2000-10-30 | 2001-10-23 | A label-free high-throughput optical technique for detecting biomolecular interactions |
PCT/US2001/045455 WO2002061429A2 (en) | 2000-10-30 | 2001-10-23 | A label-free high-throughput optical technique for detecting biomolecular interactions |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/045455 WO2002061429A2 (en) | 2000-10-30 | 2001-10-23 | A label-free high-throughput optical technique for detecting biomolecular interactions |
Country Status (6)
Country | Link |
---|---|
US (6) | US7118710B2 (en) |
EP (2) | EP2402739A1 (en) |
JP (3) | JP4202140B2 (en) |
AU (2) | AU2002249786B2 (en) |
CA (1) | CA2427689C (en) |
WO (2) | WO2002059602A2 (en) |
Families Citing this family (241)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8111401B2 (en) | 1999-11-05 | 2012-02-07 | Robert Magnusson | Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats |
US7167615B1 (en) | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
WO2001071322A2 (en) * | 2000-03-22 | 2001-09-27 | Goh M Cynthia | Method and apparatus for multiple-analyte assay |
US6951715B2 (en) * | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7306827B2 (en) * | 2000-10-30 | 2007-12-11 | Sru Biosystems, Inc. | Method and machine for replicating holographic gratings on a substrate |
US7615339B2 (en) * | 2000-10-30 | 2009-11-10 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
US7575939B2 (en) | 2000-10-30 | 2009-08-18 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7371562B2 (en) * | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
US7217574B2 (en) * | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
US7202076B2 (en) * | 2000-10-30 | 2007-04-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US7118710B2 (en) | 2000-10-30 | 2006-10-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US7142296B2 (en) * | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
US7264973B2 (en) * | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
US20030092075A1 (en) * | 2000-10-30 | 2003-05-15 | Sru Biosystems, Llc | Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors |
US7300803B2 (en) * | 2000-10-30 | 2007-11-27 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
US7175980B2 (en) * | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
US7070987B2 (en) * | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
US7524625B2 (en) * | 2000-10-30 | 2009-04-28 | Sru Biosystems, Inc. | Real time binding analysis of antigens on a biosensor surface |
US7875434B2 (en) | 2000-10-30 | 2011-01-25 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
US7023544B2 (en) * | 2000-10-30 | 2006-04-04 | Sru Biosystems, Inc. | Method and instrument for detecting biomolecular interactions |
US7153702B2 (en) * | 2000-10-30 | 2006-12-26 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
AUPR378001A0 (en) * | 2001-03-16 | 2001-04-12 | Proteome Systems Ltd | Protein chip |
US20050019942A1 (en) * | 2001-03-16 | 2005-01-27 | Proteome Systems Ltd. | Array-based biomolecule analysis |
US6862398B2 (en) * | 2001-03-30 | 2005-03-01 | Texas Instruments Incorporated | System for directed molecular interaction in surface plasmon resonance analysis |
US20040166593A1 (en) * | 2001-06-22 | 2004-08-26 | Nolte David D. | Adaptive interferometric multi-analyte high-speed biosensor |
US6977722B2 (en) | 2001-06-29 | 2005-12-20 | Meso Scale Technologies, Llc. | Assay plates, reader systems and methods for luminescence test measurements |
WO2003014711A1 (en) * | 2001-08-07 | 2003-02-20 | Mitsubishi Chemical Corporation | Surface plasmon resonance sensor chip, and sample analysis method and analysis apparatus using the same |
US7314749B2 (en) * | 2001-09-13 | 2008-01-01 | Axela Biosensors Inc. | Method and apparatus for assay based on light diffraction |
US6908678B2 (en) * | 2002-01-18 | 2005-06-21 | Advanced Gene Technology, Corp. | Plastic slides for the fabrication of biochips |
US7428367B2 (en) * | 2002-10-17 | 2008-09-23 | Brilliant Film Llc | Light control devices and methods of making same |
US7345824B2 (en) * | 2002-03-26 | 2008-03-18 | Trivium Technologies, Inc. | Light collimating device |
US7074311B1 (en) | 2002-05-08 | 2006-07-11 | Sru Biosystems Inc. | Biosensor electrophoresis |
US20040043508A1 (en) * | 2002-09-03 | 2004-03-04 | Frutos Anthony G. | Polymer-coated substrates for binding biological molecules |
US7927822B2 (en) | 2002-09-09 | 2011-04-19 | Sru Biosystems, Inc. | Methods for screening cells and antibodies |
US7429492B2 (en) * | 2002-09-09 | 2008-09-30 | Sru Biosystems, Inc. | Multiwell plates with integrated biosensors and membranes |
EP1540588A1 (en) * | 2002-09-12 | 2005-06-15 | Cyvera Corporation | Diffraction grating-based optical identification element |
US7449146B2 (en) * | 2002-09-30 | 2008-11-11 | 3M Innovative Properties Company | Colorimetric sensor |
US20040062682A1 (en) * | 2002-09-30 | 2004-04-01 | Rakow Neal Anthony | Colorimetric sensor |
JP3786073B2 (en) | 2002-10-10 | 2006-06-14 | 株式会社日立製作所 | Biochemical sensor kit and measuring device |
AU2003286739A1 (en) | 2002-10-28 | 2004-05-25 | University Of Washington | Wavelength tunable surface plasmon resonance sensor |
US20040091397A1 (en) * | 2002-11-07 | 2004-05-13 | Corning Incorporated | Multiwell insert device that enables label free detection of cells and other objects |
US7309614B1 (en) | 2002-12-04 | 2007-12-18 | Sru Biosystems, Inc. | Self-referencing biodetection method and patterned bioassays |
US7027163B2 (en) * | 2003-01-24 | 2006-04-11 | General Dynamics Advanced Information Systems, Inc. | Grating sensor |
JP4295536B2 (en) * | 2003-03-25 | 2009-07-15 | 株式会社リコー | Image forming apparatus |
WO2005012886A1 (en) * | 2003-03-27 | 2005-02-10 | Corning Incorporated | Label-free evanescent-field detection of biological and chemical agents |
US7294360B2 (en) | 2003-03-31 | 2007-11-13 | Planar Systems, Inc. | Conformal coatings for micro-optical elements, and method for making the same |
US7497992B2 (en) * | 2003-05-08 | 2009-03-03 | Sru Biosystems, Inc. | Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers |
EP1654346B1 (en) | 2003-06-12 | 2017-08-02 | Accupath Diagnostic Laboratories, Inc. | Method and system for the analysis of high density cells samples |
US7057720B2 (en) * | 2003-06-24 | 2006-06-06 | Corning Incorporated | Optical interrogation system and method for using same |
US7292333B2 (en) * | 2003-06-24 | 2007-11-06 | Corning Incorporated | Optical interrogation system and method for 2-D sensor arrays |
US20050018944A1 (en) * | 2003-07-25 | 2005-01-27 | Mozdy Eric J. | Polarization modulation interrogation of grating-coupled waveguide sensors |
US6985664B2 (en) * | 2003-08-01 | 2006-01-10 | Corning Incorporated | Substrate index modification for increasing the sensitivity of grating-coupled waveguides |
US8298780B2 (en) | 2003-09-22 | 2012-10-30 | X-Body, Inc. | Methods of detection of changes in cells |
US20050070027A1 (en) * | 2003-09-30 | 2005-03-31 | Jacques Gollier | Double resonance interrogation of grating-coupled waveguides |
JP2007510928A (en) * | 2003-11-06 | 2007-04-26 | エス アール ユー バイオシステムズ,インコーポレイテッド | High density amine functionalized surface |
US20050148063A1 (en) * | 2003-12-24 | 2005-07-07 | Cracauer Raymond F. | Disposable reaction vessel with integrated optical elements |
US6990259B2 (en) * | 2004-03-29 | 2006-01-24 | Sru Biosystems, Inc. | Photonic crystal defect cavity biosensor |
US20060002656A1 (en) * | 2004-05-25 | 2006-01-05 | Cowan James J | Surface relief structure |
US7239395B2 (en) * | 2004-05-27 | 2007-07-03 | Corning Incorporated | Optical interrogation systems with reduced parasitic reflections and a method for filtering parasitic reflections |
US7203386B2 (en) * | 2004-09-21 | 2007-04-10 | Corning Incorporated | Self-referencing waveguide grating sensors |
US7524672B2 (en) * | 2004-09-22 | 2009-04-28 | Sandia Corporation | Microfluidic microarray systems and methods thereof |
US7592139B2 (en) | 2004-09-24 | 2009-09-22 | Sandia National Laboratories | High temperature flow-through device for rapid solubilization and analysis |
WO2006047408A2 (en) * | 2004-10-22 | 2006-05-04 | Vanderbilt University | On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes |
US7136550B2 (en) * | 2004-10-28 | 2006-11-14 | Corning Incorporated | Single-fiber launch/receive system for biosensing applications |
US7285420B2 (en) * | 2004-11-18 | 2007-10-23 | Corning Incorporated | System and method for self-referencing a sensor in a micron-sized deep flow chamber |
US20060110594A1 (en) * | 2004-11-24 | 2006-05-25 | Frutos Anthony G | Polymer-coated substrates for binding biomolecules and methods of making and using thereof |
US7629173B2 (en) * | 2004-12-29 | 2009-12-08 | Corning Incorporated | Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors |
US20060141527A1 (en) * | 2004-12-29 | 2006-06-29 | Caracci Stephen J | Method for creating a reference region and a sample region on a biosensor and the resulting biosensor |
US7604984B2 (en) * | 2004-12-29 | 2009-10-20 | Corning Incorporated | Spatially scanned optical reader system and method for using same |
US7349080B2 (en) * | 2004-12-30 | 2008-03-25 | Corning Incorporated | Label-independent detection of unpurified analytes |
US7445887B2 (en) * | 2005-01-07 | 2008-11-04 | Fortebio, Inc. | Enzyme activity measurements using bio-layer interferometry |
US7910356B2 (en) | 2005-02-01 | 2011-03-22 | Purdue Research Foundation | Multiplexed biological analyzer planar array apparatus and methods |
US7405831B2 (en) * | 2005-02-01 | 2008-07-29 | Purdue Research Foundation | Laser scanning interferometric surface metrology |
US20070023643A1 (en) * | 2005-02-01 | 2007-02-01 | Nolte David D | Differentially encoded biological analyzer planar array apparatus and methods |
US7346233B2 (en) * | 2005-02-14 | 2008-03-18 | Corning Incorporated | Single mode (SM) fiber optical reader system and method for interrogating resonant waveguide-grating sensor(s) |
US7454094B2 (en) * | 2005-02-14 | 2008-11-18 | Corning Incorporated | Optical reader system and method that uses non-coherent illumination and angular filtering to interrogate a label independent biosensor |
CN103983772A (en) | 2005-04-05 | 2014-08-13 | 康宁股份有限公司 | Method for measuring effects of stimulating incidents on cells |
US20060223111A1 (en) * | 2005-04-05 | 2006-10-05 | Chow Kai C | Biosensor system that enables spectral multiplexing |
US20060223051A1 (en) * | 2005-04-05 | 2006-10-05 | Ye Fang | System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors |
US7871811B2 (en) * | 2005-04-07 | 2011-01-18 | Corning Incorporated | Method for eliminating crosstalk between waveguide grating-based biosensors located in a microplate and the resulting microplate |
NZ562794A (en) * | 2005-04-12 | 2010-07-30 | Sru Biosystems Inc | Proteolipid membrane & lipid membrane biosensor using a titanium surface |
KR20080009280A (en) * | 2005-05-18 | 2008-01-28 | 더글라스 에스. 홉스 | Microstructured optical device for polarization and wavelength filtering |
US20070081163A1 (en) * | 2005-06-03 | 2007-04-12 | Minhua Liang | Method and apparatus for scanned beam microarray assay |
US20070139653A1 (en) * | 2005-06-07 | 2007-06-21 | Guan Hann W | MEMS Micromirror Surface Plasmon Resonance Biosensor and Method |
US20100261288A1 (en) | 2005-06-13 | 2010-10-14 | Fortebio, Inc. | Tip tray assembly for optical sensors |
US7718326B2 (en) * | 2005-06-17 | 2010-05-18 | Vincent E Stenger | Seamless stitching of patterns formed by interference lithography |
US7197198B2 (en) * | 2005-06-23 | 2007-03-27 | Sru Biosystems, Inc. | Biosensor substrate structure for reducing the effects of optical interference |
US7162125B1 (en) * | 2005-06-23 | 2007-01-09 | Sru Biosystems, Inc. | Optimized grating based biosensor and substrate combination |
US7479404B2 (en) * | 2005-07-08 | 2009-01-20 | The Board Of Trustees Of The University Of Illinois | Photonic crystal biosensor structure and fabrication method |
US7521769B2 (en) * | 2005-07-08 | 2009-04-21 | Sru Biosystems, Inc. | Photonic crystal biosensor structure and fabrication method |
CN101228446B (en) | 2005-07-20 | 2014-08-06 | 康宁股份有限公司 | Label-free high throughput biomolecular screening system and method |
US7483127B1 (en) | 2005-08-08 | 2009-01-27 | Sru Biosystems, Inc. | Method and apparatus for generating an image of biomolecular sensor target area |
KR101006793B1 (en) * | 2005-08-11 | 2011-01-10 | 에스알유 바이오시스템즈, 인코포레이티드 | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
US7790406B2 (en) * | 2005-08-11 | 2010-09-07 | Sru Biosystems, Inc | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
US7889347B2 (en) | 2005-11-21 | 2011-02-15 | Plexera Llc | Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism |
US7463358B2 (en) | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
US8355136B2 (en) | 2005-12-16 | 2013-01-15 | Indiana University Research And Technology Corporation | Sub-micron surface plasmon resonance sensor systems |
EP1969351A4 (en) * | 2005-12-16 | 2010-12-29 | Univ Indiana Res & Tech Corp | Sub-micron surface plasmon resonance sensor systems |
US7781203B2 (en) | 2005-12-29 | 2010-08-24 | Corning Incorporated | Supports for assaying analytes and methods of making and using thereof |
US7474396B2 (en) * | 2006-01-17 | 2009-01-06 | Hewlett-Packard Development Company, L.P. | Raman spectroscopy system and method using a subwavelength resonant grating filter |
AU2007217078A1 (en) * | 2006-02-16 | 2007-08-30 | Purdue Research Foundation | In-line quadrature and anti-reflection enhanced phase quadrature interferometric detection |
JP4365832B2 (en) * | 2006-03-07 | 2009-11-18 | 株式会社日立製作所 | Biochemical analysis cell, biochemical analysis kit and biochemical analysis device |
US7854505B2 (en) * | 2006-03-15 | 2010-12-21 | The Board Of Trustees Of The University Of Illinois | Passive and active photonic crystal structures and devices |
US20070223866A1 (en) * | 2006-03-22 | 2007-09-27 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Controllable electromagnetically responsive assembly of self resonant bodies |
FR2900279B1 (en) * | 2006-04-19 | 2008-06-06 | Commissariat Energie Atomique | MICRO-STRUCTURE SPECTRAL FILTER AND IMAGE SENSOR |
US20070264155A1 (en) * | 2006-05-09 | 2007-11-15 | Brady Michael D | Aerosol jet deposition method and system for creating a reference region/sample region on a biosensor |
US7809441B2 (en) | 2006-05-17 | 2010-10-05 | Cardiac Pacemakers, Inc. | Implantable medical device with chemical sensor and related methods |
US7767143B2 (en) | 2006-06-27 | 2010-08-03 | 3M Innovative Properties Company | Colorimetric sensors |
US7756365B2 (en) * | 2006-07-07 | 2010-07-13 | University Of Illinois | Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio |
US8158374B1 (en) | 2006-09-05 | 2012-04-17 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
WO2008033535A2 (en) * | 2006-09-14 | 2008-03-20 | Fortebio, Inc. | Amine-reactive biosensor |
US7976217B2 (en) * | 2006-09-15 | 2011-07-12 | Corning Incorporated | Screening system and method for analyzing a plurality of biosensors |
US20080191604A1 (en) * | 2006-09-27 | 2008-08-14 | Evident Technologies | Retro-emission systems comprising microlens arrays and luminescent emitters |
AU2007313830A1 (en) * | 2006-10-31 | 2008-05-08 | Sru Biosystems, Inc. | Method for blocking non-specific protein binding on a functionalized surface |
US7531786B2 (en) * | 2006-11-09 | 2009-05-12 | The Board Of Trustees Of The Universiy Of Illinois | Photonic crystal sensors with integrated fluid containment structure |
US7737392B2 (en) * | 2006-11-09 | 2010-06-15 | The Board Of Trustees Of The University Of Illinois | Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis |
US7628085B2 (en) * | 2006-11-17 | 2009-12-08 | Sru Biosystems, Inc. | Simultaneous aspirator and dispenser for multiwell plates and similar devices |
US7999440B2 (en) * | 2006-11-27 | 2011-08-16 | Bioscale, Inc. | Micro-fabricated devices having a suspended membrane or plate structure |
US20080230605A1 (en) * | 2006-11-30 | 2008-09-25 | Brian Weichel | Process and apparatus for maintaining data integrity |
KR100927590B1 (en) | 2006-12-05 | 2009-11-23 | 한국전자통신연구원 | Resonant Reflective Light Filter and Biosensor Using the Same |
KR100899811B1 (en) * | 2006-12-05 | 2009-05-27 | 한국전자통신연구원 | Guided mode resonance filter including high refractive index organic material and optical biosensor having the same |
GB2444962B (en) * | 2006-12-22 | 2010-01-27 | Univ Muenster Wilhelms | Adaptive crystalline X-ray reflecting device |
WO2008089495A2 (en) | 2007-01-19 | 2008-07-24 | Purdue Research Foundation | System with extended range of molecular sensing through integrated multi-modal data acquisition |
US7599055B2 (en) * | 2007-02-27 | 2009-10-06 | Corning Incorporated | Swept wavelength imaging optical interrogation system and method for using same |
CA2681722A1 (en) | 2007-03-26 | 2008-10-02 | Purdue Research Foundation | Method and apparatus for conjugate quadrature interferometric detection of an immunoassay |
CN100458444C (en) * | 2007-03-28 | 2009-02-04 | 山东轻工业学院 | Micro-pool array chip processing method capable of being as ultra microhole analytical plate |
US20080240543A1 (en) * | 2007-03-30 | 2008-10-02 | Wolfgang Ernst Gustav Budach | Calibration and normalization method for biosensors |
WO2008123927A1 (en) * | 2007-04-05 | 2008-10-16 | The Board Of Trustees Of The University Of Illinois | Biosensors with porous dielectric surface for fluorescence enhancement and methods of manufacture |
CA2683082A1 (en) * | 2007-04-19 | 2008-10-30 | Sru Biosystems, Inc. | Method for employing a biosensor to detect small molecules that bind directly to immobilized targets |
JP2010524465A (en) * | 2007-04-19 | 2010-07-22 | コーニング インコーポレイテッド | Live cell signals of pathogen invasion and methods thereof |
US7768640B2 (en) * | 2007-05-07 | 2010-08-03 | The Board Of Trustees Of The University Of Illinois | Fluorescence detection enhancement using photonic crystal extraction |
US7835013B2 (en) * | 2007-05-18 | 2010-11-16 | Vanderbilt University | Interferometric detection system and method |
US9134307B2 (en) | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
CA2693700A1 (en) | 2007-07-11 | 2009-01-15 | Sru Biosystems, Inc. | Methods for identifying modulators of ion channels |
US7576333B2 (en) * | 2007-08-01 | 2009-08-18 | Corning Incorporated | Optical interrogation system and method for using same |
US20090309617A1 (en) * | 2007-08-24 | 2009-12-17 | Ye Fang | Biosensor antibody functional mapping |
US8445217B2 (en) | 2007-09-20 | 2013-05-21 | Vanderbilt University | Free solution measurement of molecular interactions by backscattering interferometry |
JP4597175B2 (en) * | 2007-09-21 | 2010-12-15 | 株式会社日立ハイテクノロジーズ | Analytical apparatus for detecting a target substance, analytical method, or device used in these analytical apparatus and analytical method |
US20090093011A1 (en) * | 2007-10-05 | 2009-04-09 | Ye Fang | Biosensors for ligand-directed functional selectivity |
US20090325211A1 (en) * | 2007-10-06 | 2009-12-31 | Ye Fang | System and method for dual-detection of a cellular response |
US8703428B2 (en) * | 2007-10-06 | 2014-04-22 | Corning Incorporated | Single-cell label-free assay |
US8426148B2 (en) | 2007-10-06 | 2013-04-23 | Corning Incorporated | Label-free methods using a resonant waveguide grating biosensor to determine GPCR signaling pathways |
US7978893B2 (en) * | 2007-10-12 | 2011-07-12 | Corning Incorporated | System and method for microplate image analysis |
US8004669B1 (en) | 2007-12-18 | 2011-08-23 | Plexera Llc | SPR apparatus with a high performance fluid delivery system |
US20090181409A1 (en) * | 2008-01-10 | 2009-07-16 | Ye Fang | Optical biosensor method for cell-cell interaction |
TW200946775A (en) | 2008-02-27 | 2009-11-16 | Brilliant Film Llc | Concentrators for solar power generating systems |
US8759013B2 (en) | 2008-03-05 | 2014-06-24 | Corning Incorporated | Dual-target biosensor cell assays |
US8846575B2 (en) | 2008-03-05 | 2014-09-30 | Corning Incorporated | High-throughput high-information content label-free cell biology screening methods |
US8313898B2 (en) | 2008-03-05 | 2012-11-20 | Corning Incorporated | Dual-target biosensor cell assays |
US8257936B2 (en) | 2008-04-09 | 2012-09-04 | X-Body Inc. | High resolution label free analysis of cellular properties |
US20100015721A1 (en) * | 2008-06-04 | 2010-01-21 | Sru Biosystems, Inc. | Detection of Promiscuous Small Submicrometer Aggregates |
US20100008826A1 (en) * | 2008-07-10 | 2010-01-14 | Sru Biosystems, Inc. | Biosensors featuring confinement of deposited material and intra-well self-referencing |
US8384892B2 (en) | 2008-10-03 | 2013-02-26 | Board Of Trustees Of The University Of Illinois | Surface enhanced raman spectroscopy on optical resonator (e.g., photonic crystal) surfaces |
US8953159B2 (en) | 2008-10-03 | 2015-02-10 | The Board Of Trustees Of The University Of Illinois | Surface enhanced raman spectroscopy nanodome biosensors and methods of manufacturing the same |
CA2740736A1 (en) * | 2008-10-15 | 2010-04-22 | Ridge Diagnostics, Inc. | Human biomarker hypermapping for depressive disorders |
US7999944B2 (en) * | 2008-10-23 | 2011-08-16 | Corning Incorporated | Multi-channel swept wavelength optical interrogation system and method for using same |
KR101065078B1 (en) | 2008-11-05 | 2011-09-15 | 삼성전자주식회사 | A substate for bio-chip and manufacturing method of the same |
WO2010059709A2 (en) * | 2008-11-18 | 2010-05-27 | Ridge Diagnostics, Inc. | Metabolic syndrome and hpa axis biomarkers for major depressive disorder |
CA2748946A1 (en) * | 2009-02-02 | 2010-08-05 | Sru Biosystems, Inc. | Efficient optical arrangement for illumination and detection of label-free biosensors and method to reduce interference fringes in label-free imaging |
JPWO2010110415A1 (en) * | 2009-03-27 | 2012-10-04 | 株式会社村田製作所 | Method for measuring characteristics of object to be measured, structure with diffraction phenomenon, and measuring apparatus |
WO2010118035A2 (en) * | 2009-04-06 | 2010-10-14 | Ridge Diagnostics, Inc. | Biomarkers for monitoring treatment of neuropsychiatric diseases |
US20100273185A1 (en) * | 2009-04-27 | 2010-10-28 | Sru Biosystems, Inc. | Detection of Biased Agonist Activation |
EP2246693A1 (en) | 2009-04-29 | 2010-11-03 | Karlsruher Institut für Technologie | Optical element, method for proving the presence of substances and use of the optical element |
DE102009019717A1 (en) | 2009-05-05 | 2010-11-11 | Karlsruher Institut für Technologie | Method and use of an optical grating for detecting the presence of molecules |
CN102460171A (en) * | 2009-05-15 | 2012-05-16 | Sru生物系统公司 | Detection of changes in cell populations and mixed cell populations |
WO2011017147A1 (en) * | 2009-08-05 | 2011-02-10 | Corning Incorporated | Label-independent optical reader system and methods with optical scanning |
JP5384648B2 (en) * | 2009-08-21 | 2014-01-08 | 株式会社村田製作所 | Method for measuring the characteristics of the object to be measured |
US8593630B2 (en) * | 2009-10-07 | 2013-11-26 | The Board Of Trustees Of The University Of Illinois | Discrete frequency spectroscopy and instrumentation |
CN102884428A (en) * | 2010-01-26 | 2013-01-16 | 里奇诊断学股份有限公司 | Multiple biomarker panels to stratify disease severity and monitor treatment of depression |
US9151891B2 (en) * | 2010-02-12 | 2015-10-06 | The Regents Of The University Of California | Metamaterial-based optical lenses |
US20110207789A1 (en) * | 2010-02-19 | 2011-08-25 | Ye Fang | Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents |
JPWO2011111785A1 (en) | 2010-03-10 | 2013-06-27 | 国立大学法人東京工業大学 | Layer structure for measuring reflected light intensity, apparatus comprising layer structure for measuring reflected light, and method for measuring film thickness and / or mass and / or viscosity of thin film |
US20110236911A1 (en) * | 2010-03-18 | 2011-09-29 | Fortebio, Inc. | Precipitating Substrate for Bio-Layer Interferometry |
KR20110106684A (en) * | 2010-03-23 | 2011-09-29 | 삼성전자주식회사 | Microarray package device and method for manufacturing the same |
EP2553151A4 (en) * | 2010-03-26 | 2013-07-31 | X Body Inc | Use of induced pluripotent cells and other cells for screening compound libraries |
US8974651B2 (en) | 2010-04-17 | 2015-03-10 | C.C. Imex | Illuminator for visualization of fluorophores |
US8472031B2 (en) | 2010-05-25 | 2013-06-25 | Valerio Pruneri | Apparatus and method for optical interrogation |
WO2011156713A1 (en) | 2010-06-11 | 2011-12-15 | Vanderbilt University | Multiplexed interferometric detection system and method |
US8987841B2 (en) | 2010-08-09 | 2015-03-24 | Omnivision Technologies, Inc. | Backside stimulated sensor with background current manipulation |
US8519490B2 (en) * | 2010-08-09 | 2013-08-27 | Omnivision Technologies, Inc. | Backside stimulated sensor with background current manipulation |
EP2417910B1 (en) * | 2010-08-11 | 2013-06-26 | Roche Diagnostics GmbH | Analytical test unit and test system |
CN102045752B (en) * | 2010-12-23 | 2015-09-16 | 中兴通讯股份有限公司 | User media face tracking and device |
US8310679B2 (en) * | 2011-01-31 | 2012-11-13 | Indian Institute Of Science | Apparatus and methods for sensing or imaging using stacked thin films |
US9562853B2 (en) | 2011-02-22 | 2017-02-07 | Vanderbilt University | Nonaqueous backscattering interferometric methods |
US9272126B2 (en) | 2011-04-29 | 2016-03-01 | The Board Of Trustees Of The University Of Illinois | Photonic biosensors incorporated into tubing, methods of manufacture and instruments for analyzing the biosensors |
KR101799521B1 (en) * | 2011-05-24 | 2017-11-20 | 삼성전자 주식회사 | Light modulator with photonic crystal and 3D image acquisition apparatus employing the same |
AR088054A1 (en) * | 2011-09-26 | 2014-05-07 | Sicpa Holding Sa | DEVICE AND METHOD FOR AUTHENTIFYING AN OPTICALLY VARIABLE ENTITY |
US9546219B2 (en) | 2012-02-08 | 2017-01-17 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
WO2013128614A1 (en) * | 2012-03-01 | 2013-09-06 | 日本精工株式会社 | Target-material detection device and target-material detection method |
US9273949B2 (en) | 2012-05-11 | 2016-03-01 | Vanderbilt University | Backscattering interferometric methods |
US11181448B2 (en) | 2012-11-06 | 2021-11-23 | Biodot, Inc. | Controlled printing of a cell sample for karyotyping |
US8976359B2 (en) * | 2012-12-15 | 2015-03-10 | Board Of Trustees Of The University Of Alabama, For And On Behalf Of The University Of Alabama In Huntsville | Nanostructure diffraction gratings for integrated spectroscopy and sensing |
CN103398989B (en) * | 2013-08-16 | 2015-05-20 | 中国科学院光电技术研究所 | Chip-type surface plasma spectrometer |
US9835587B2 (en) | 2014-04-01 | 2017-12-05 | C.C. Imex | Electrophoresis running tank assembly |
WO2015177654A2 (en) * | 2014-05-01 | 2015-11-26 | King Abdullah University Of Science And Technology | A microfluidic device that separates cells |
JP2018506715A (en) | 2015-01-23 | 2018-03-08 | ヴァンダービルト ユニバーシティー | Robust interferometer and method of use |
WO2016137899A1 (en) | 2015-02-23 | 2016-09-01 | Li-Cor, Inc. | Fluorescence biopsy specimen imager and methods |
EP3314234B1 (en) * | 2015-06-26 | 2021-05-19 | Li-Cor, Inc. | Fluorescence biopsy specimen imager |
US10716500B2 (en) | 2015-06-29 | 2020-07-21 | Cardiac Pacemakers, Inc. | Systems and methods for normalization of chemical sensor data based on fluid state changes |
US10801956B2 (en) | 2015-08-26 | 2020-10-13 | Photonicsys Ltd. | Resonant periodic structures and methods of using them as filters and sensors |
US20170191020A1 (en) | 2015-12-30 | 2017-07-06 | Palo Alto Research Center Incorporated | Thermochromic sensing devices, systems, and methods |
US9963732B2 (en) | 2015-12-30 | 2018-05-08 | Palo Alto Research Center Incorporated | Thermochromic sensing devices, systems, and methods |
US10598554B2 (en) * | 2015-12-30 | 2020-03-24 | Palo Alto Research Center Incorporated | Thermochromic sensing for nanocalorimetry |
US10697892B2 (en) * | 2016-01-26 | 2020-06-30 | Danmarks Tekniske Universitet | Cuvette and method for measuring refractive index in a spectrophotometer |
WO2017132483A1 (en) | 2016-01-29 | 2017-08-03 | Vanderbilt University | Free-solution response function interferometry |
WO2017136187A2 (en) * | 2016-02-01 | 2017-08-10 | Micro Detect, Inc. | Uv solid state detection and methods therefor |
US10983275B2 (en) * | 2016-03-21 | 2021-04-20 | The Regents Of The University Of Colorado, A Body Corporate | Method and apparatus for optical waveguide-to-semiconductor coupling for integrated photonic circuits |
EP3446098A1 (en) | 2016-04-21 | 2019-02-27 | Li-Cor, Inc. | Multimodality multi-axis 3-d imaging |
GB201610647D0 (en) * | 2016-06-17 | 2016-08-03 | Univ York | Improved sensor and associated methods |
US10278586B2 (en) | 2016-06-23 | 2019-05-07 | Li-Cor, Inc. | Complementary color flashing for multichannel image presentation |
WO2018089335A1 (en) | 2016-11-09 | 2018-05-17 | North Carolina State University | Treatment of allergic diseases with chimeric protein |
US10993622B2 (en) | 2016-11-23 | 2021-05-04 | Li-Cor, Inc. | Motion-adaptive interactive imaging method |
WO2018106945A1 (en) * | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
US10386301B2 (en) | 2017-04-25 | 2019-08-20 | Li-Cor, Inc. | Top-down and rotational side view biopsy specimen imager and methods |
US20180315791A1 (en) * | 2017-04-30 | 2018-11-01 | Himax Technologies Limited | Image sensor structure |
CN108968976B (en) | 2017-05-31 | 2022-09-13 | 心脏起搏器股份公司 | Implantable medical device with chemical sensor |
FR3067043B1 (en) * | 2017-06-02 | 2021-06-25 | Univ De Lille 1 Sciences Et Technologies | OPTICAL DETECTION PROCESS |
DE102017115922C5 (en) * | 2017-07-14 | 2023-03-23 | Precitec Gmbh & Co. Kg | Method and device for measuring and setting a distance between a machining head and a workpiece and associated method for regulation |
CN109381195B (en) | 2017-08-10 | 2023-01-10 | 心脏起搏器股份公司 | Systems and methods including electrolyte sensor fusion |
CN109419515B (en) | 2017-08-23 | 2023-03-24 | 心脏起搏器股份公司 | Implantable chemical sensor with staged activation |
CN109864746B (en) | 2017-12-01 | 2023-09-29 | 心脏起搏器股份公司 | Multimode analyte sensor for medical devices |
CN109864747B (en) | 2017-12-05 | 2023-08-25 | 心脏起搏器股份公司 | Multimode analyte sensor optoelectronic interface |
US11402669B2 (en) | 2018-04-27 | 2022-08-02 | Apple Inc. | Housing surface with tactile friction features |
CN112585083A (en) | 2018-05-15 | 2021-03-30 | 杜兰教育基金委员会 | Refractive index sensor and method |
US11112827B2 (en) | 2018-07-20 | 2021-09-07 | Apple Inc. | Electronic device with glass housing member |
AU2019326534A1 (en) | 2018-08-24 | 2021-02-11 | Zoetis Services Llc | Microfluidic rotor device |
MX2021002156A (en) | 2018-08-24 | 2021-04-28 | Zoetis Services Llc | Methods for manufacturing a microfluidic rotor device. |
CN112638531B (en) * | 2018-08-24 | 2022-12-13 | 硕腾服务有限责任公司 | Microfluidic rotor apparatus |
US11691912B2 (en) | 2018-12-18 | 2023-07-04 | Apple Inc. | Chemically strengthened and textured glass housing member |
CN109459813A (en) * | 2018-12-26 | 2019-03-12 | 上海鲲游光电科技有限公司 | A kind of planar optical waveguide based on two-dimensional grating |
US11199929B2 (en) | 2019-03-21 | 2021-12-14 | Apple Inc. | Antireflective treatment for textured enclosure components |
CN110095416B (en) * | 2019-04-29 | 2021-10-08 | 西北核技术研究所 | Metal molten pool laser absorption rate distribution on-line measuring system and method |
US11372137B2 (en) | 2019-05-29 | 2022-06-28 | Apple Inc. | Textured cover assemblies for display applications |
US11109500B2 (en) | 2019-06-05 | 2021-08-31 | Apple Inc. | Textured glass component for an electronic device enclosure |
US11192823B2 (en) * | 2019-06-05 | 2021-12-07 | Apple Inc. | Electronic devices including laser-textured glass cover members |
US10827635B1 (en) | 2019-06-05 | 2020-11-03 | Apple Inc. | Electronic device enclosure having a textured glass component |
FR3097050B1 (en) | 2019-06-07 | 2021-08-27 | Centre Nat Rech Scient | Method and device for analyzing a sample, using a resonant support. |
US11925456B2 (en) * | 2020-04-29 | 2024-03-12 | Hyperspectral Corp. | Systems and methods for screening asymptomatic virus emitters |
CN111781672B (en) * | 2020-07-28 | 2022-02-25 | 中国人民解放军国防科技大学 | Two-dimensional single-core fiber grating and writing method thereof |
US11897809B2 (en) | 2020-09-02 | 2024-02-13 | Apple Inc. | Electronic devices with textured glass and glass ceramic components |
CN113009609A (en) * | 2021-03-01 | 2021-06-22 | 苏州大学 | Volume grating calibration assembly, volume grating preparation device, calibration method and exposure method |
Family Cites Families (211)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US457685A (en) * | 1891-08-11 | Guide for rolling-mills | ||
US707987A (en) * | 1901-07-26 | 1902-08-26 | William C Beddow | Lock-up for printers' forms. |
US3100991A (en) * | 1961-10-30 | 1963-08-20 | Gen Electric | Reversible hydraulic torque applier |
US3689346A (en) * | 1970-09-29 | 1972-09-05 | Rowland Dev Corp | Method for producing retroreflective material |
US3856604A (en) * | 1971-09-24 | 1974-12-24 | Konttorikoneteollisuus Oy | Machine for selectively cutting and gluing address labels |
US3916182A (en) | 1972-08-21 | 1975-10-28 | Western Electric Co | Periodic dielectric waveguide filter |
US3810688A (en) * | 1973-05-21 | 1974-05-14 | A Ballman | Optical waveguiding devices using monocrystalline materials of the sillenite family of bismuth oxides |
US3856404A (en) | 1973-06-06 | 1974-12-24 | Phys Chem Res Corp | Method and apparatus for measuring vapor pressure |
US4009933A (en) * | 1975-05-07 | 1977-03-01 | Rca Corporation | Polarization-selective laser mirror |
US4050895A (en) * | 1975-09-26 | 1977-09-27 | Monsanto Research Corporation | Optical analytical device, waveguide and method |
US4668558A (en) * | 1978-07-20 | 1987-05-26 | Minnesota Mining And Manufacturing Company | Shaped plastic articles having replicated microstructure surfaces |
US4576850A (en) | 1978-07-20 | 1986-03-18 | Minnesota Mining And Manufacturing Company | Shaped plastic articles having replicated microstructure surfaces |
US4344438A (en) * | 1978-08-02 | 1982-08-17 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Optical sensor of plasma constituents |
US4240751A (en) | 1978-11-09 | 1980-12-23 | Akzona Incorporated | Method and apparatus for specific binding substances |
US4289371A (en) | 1979-05-31 | 1981-09-15 | Xerox Corporation | Optical scanner using plane linear diffraction gratings on a rotating spinner |
US4321057A (en) | 1979-09-20 | 1982-03-23 | Buckles Richard G | Method for quantitative analysis using optical fibers |
US4420502A (en) * | 1980-09-05 | 1983-12-13 | Conley Kenneth E | Apparatus and method for producing a flexible sheet material having a predetermined surface characteristic |
GB2103786A (en) * | 1981-08-14 | 1983-02-23 | Ici Plc | Fibre optic sensor |
EP0075353B1 (en) | 1981-09-18 | 1987-08-19 | Battelle Memorial Institute | Method and apparatus for the determination of species in solution with an optical wave-guide |
USRE33064E (en) * | 1981-09-18 | 1989-09-19 | Prutec Limited | Method for the determination of species in solution with an optical wave-guide |
FI74371C (en) * | 1982-06-04 | 1988-01-11 | British Telecomm | Optical transmission. |
CA1237645A (en) * | 1982-12-21 | 1988-06-07 | John H. Fisher | Assay technique |
US4536608A (en) * | 1983-04-25 | 1985-08-20 | Exxon Research And Engineering Co. | Solar cell with two-dimensional hexagonal reflecting diffraction grating |
US4652290A (en) | 1983-07-05 | 1987-03-24 | Motorola, Inc. | Method for making optical channel waveguides and product manufactured thereby |
GB2156970B (en) | 1984-01-06 | 1987-09-16 | Plessey Co Plc | Optical detection of specific molecules |
CA1231136A (en) * | 1984-06-13 | 1988-01-05 | Ian A. Shanks | Capillary action chemical test device |
US4701008A (en) * | 1984-08-10 | 1987-10-20 | Motorola, Inc. | Optical waveguide including superstrate of niobium or silicon oxynitride and method of making same |
GB8423204D0 (en) * | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
US4650329A (en) * | 1984-11-29 | 1987-03-17 | The United States Of America As Represented By The Secretary Of The Navy | Optical 3-d signature device for detecting chemical agents |
EP0184600B1 (en) * | 1984-12-10 | 1990-03-14 | Prutec Limited | Method for optically ascertaining parameters of species in a liquid analyte |
GB8509491D0 (en) * | 1985-04-12 | 1985-05-15 | Plessey Co Plc | Optic waveguide biosensors |
CH670521A5 (en) | 1985-05-29 | 1989-06-15 | Oerlikon Buehrle Holding Ag | Optical sensor detecting specific substances in material |
CH669050A5 (en) | 1985-05-29 | 1989-02-15 | Oerlikon Buehrle Holding Ag | Optical sensor detecting specific substances in material |
DE3680999D1 (en) * | 1985-05-29 | 1991-09-26 | Artificial Sensing Instr Asi A | OPTICAL SENSOR FOR SELECTIVE DETECTION OF SUBSTANCES AND DETECTION OF REFRIGERATION CHANGES IN MEASURING SUBSTANCES. |
USRE33084E (en) * | 1985-11-13 | 1989-10-10 | Intermittently operating pneumatic device for pumping solid-carrying liquids and slurries | |
US5148302A (en) * | 1986-04-10 | 1992-09-15 | Akihiko Nagano | Optical modulation element having two-dimensional phase type diffraction grating |
GB8618133D0 (en) * | 1986-07-24 | 1986-09-03 | Pa Consulting Services | Biosensors |
US4876208A (en) * | 1987-01-30 | 1989-10-24 | Yellowstone Diagnostics Corporation | Diffraction immunoassay apparatus and method |
GB8705649D0 (en) * | 1987-03-10 | 1987-04-15 | Pa Consulting Services | Assay sensor |
US4999234A (en) * | 1987-08-10 | 1991-03-12 | Polaroid Corporation | Holographic optical data storage medium |
US4888260A (en) * | 1987-08-10 | 1989-12-19 | Polaroid Corporation | Volume phase reflection holograms and methods for fabricating them |
GB8801807D0 (en) | 1988-01-27 | 1988-02-24 | Amersham Int Plc | Biological sensors |
NL8800219A (en) | 1988-01-29 | 1989-08-16 | Philips Nv | ROTATABLE MAGNETIC UNIT FOR A MAGNETIC TAPE DEVICE. |
US4952056A (en) * | 1988-05-17 | 1990-08-28 | Entwicklungsgemeinschaft Asi | Method of determining the autocollimation angle of a grating coupler |
GB2220080A (en) * | 1988-06-24 | 1989-12-28 | Marconi Gec Ltd | Improvements in optical waveguides |
US6235488B1 (en) * | 1988-09-29 | 2001-05-22 | Agilent Technologies, Inc. | Surface preparation for chemical-specific binding |
SE462454B (en) * | 1988-11-10 | 1990-06-25 | Pharmacia Ab | METHOD FOR USE IN BIOSENSORS |
SE8804074D0 (en) * | 1988-11-10 | 1988-11-10 | Pharmacia Ab | SENSOR UNIT AND ITS USE IN BIOSENSOR SYSTEM |
GB2227089A (en) | 1989-01-11 | 1990-07-18 | Plessey Co Plc | An optical biosensor |
US5175030A (en) | 1989-02-10 | 1992-12-29 | Minnesota Mining And Manufacturing Company | Microstructure-bearing composite plastic articles and method of making |
GB8916764D0 (en) * | 1989-07-21 | 1989-09-06 | Sambles John R | Surface plasmon optical sensor |
US5156785A (en) * | 1991-07-10 | 1992-10-20 | Cordis Corporation | Extruded tubing and catheters having increased rotational stiffness |
US5541057A (en) * | 1989-09-18 | 1996-07-30 | Biostar, Inc. | Methods for detection of an analyte |
WO1991013339A1 (en) | 1990-03-02 | 1991-09-05 | Fisons Plc | Sample cell for use in chemical or biochemical assays |
EP0455067B1 (en) * | 1990-05-03 | 2003-02-26 | F. Hoffmann-La Roche Ag | Micro-optical sensor |
IL98150A0 (en) * | 1990-05-17 | 1992-08-18 | Adeza Biomedical Corp | Highly reflective biogratings and method for theirhighly reflective biogratings and method production |
US5478756A (en) * | 1990-07-24 | 1995-12-26 | Fisons Plc | Chemical sensor for detecting binding reactions |
US5337183A (en) * | 1991-02-01 | 1994-08-09 | Yeda Research And Development Co. Ltd. | Distributed resonant cavity light beam modulator |
SE468188B (en) * | 1991-04-08 | 1992-11-16 | Stiftelsen Inst Foer Mikroelek | METHOD FOR CONNECTING RADIATION IN AN INFRARED DETECTOR, APPLIED DEVICE |
CA2086338C (en) * | 1991-04-26 | 2002-03-26 | Rino E. Kunz | Process and device for determining measured quantities by means of an integrated optical sensor module |
US5155785A (en) * | 1991-05-01 | 1992-10-13 | At&T Bell Laboratories | Optical fiber interconnection apparatus and method |
GB9111912D0 (en) * | 1991-06-04 | 1991-07-24 | Fisons Plc | Analytical methods |
GB2256477B (en) * | 1991-06-07 | 1995-03-08 | Marconi Gec Ltd | An optical sensor |
US5216680A (en) | 1991-07-11 | 1993-06-01 | Board Of Regents, The University Of Texas System | Optical guided-mode resonance filter |
US5170448A (en) * | 1992-01-06 | 1992-12-08 | Motorola, Inc. | Optical waveguide apparatus and method for partially collecting light |
GB9200562D0 (en) | 1992-01-11 | 1992-03-11 | Fisons Plc | Analytical device with polychromatic light source |
US5268782A (en) | 1992-01-16 | 1993-12-07 | Minnesota Mining And Manufacturing Company | Micro-ridged, polymeric liquid crystal display substrate and display device |
US5494829A (en) * | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
US5413884A (en) * | 1992-12-14 | 1995-05-09 | American Telephone And Telegraph Company | Grating fabrication using electron beam lithography |
US5615052A (en) * | 1993-04-16 | 1997-03-25 | Bruce W. McCaul | Laser diode/lens assembly |
US5281343A (en) * | 1993-04-20 | 1994-01-25 | Ingersoll-Rand Company | Vacuum filtration system and method of filtering pulp fibers from pulp slurry using the same |
US5512492A (en) * | 1993-05-18 | 1996-04-30 | University Of Utah Research Foundation | Waveguide immunosensor with coating chemistry providing enhanced sensitivity |
ES2102857T3 (en) * | 1993-06-11 | 1997-08-01 | Minnesota Mining & Mfg | REPRODUCTION TOOL MACHINED BY LASER. |
US5475780A (en) * | 1993-06-17 | 1995-12-12 | At&T Corp. | Optical waveguiding component comprising a band-pass filter |
US5395587A (en) * | 1993-07-06 | 1995-03-07 | Smithkline Beecham Corporation | Surface plasmon resonance detector having collector for eluted ligate |
GB9314991D0 (en) | 1993-07-20 | 1993-09-01 | Sandoz Ltd | Mechanical device |
AU679968B2 (en) * | 1993-09-13 | 1997-07-17 | Minnesota Mining And Manufacturing Company | Abrasive article, method of manufacture of same, method of using same for finishing, and a production tool |
US6042998A (en) * | 1993-09-30 | 2000-03-28 | The University Of New Mexico | Method and apparatus for extending spatial frequencies in photolithography images |
US5691846A (en) | 1993-10-20 | 1997-11-25 | Minnesota Mining And Manufacturing Company | Ultra-flexible retroreflective cube corner composite sheetings and methods of manufacture |
US5559338A (en) * | 1994-10-04 | 1996-09-24 | Excimer Laser Systems, Inc. | Deep ultraviolet optical imaging system for microlithography and/or microfabrication |
US5955335A (en) | 1994-10-08 | 1999-09-21 | Foschungszentrum Julich GmbH | Biomaterial immobilization on an Si3 N4 surface containing Si-NH2 groups with a heterobifunctional cross-linking agent |
TW323341B (en) * | 1995-01-09 | 1997-12-21 | Minnesota Mining & Mfg | |
US5606170A (en) * | 1995-02-03 | 1997-02-25 | Research International, Inc. | Multifunctional sensor system |
US5601997A (en) * | 1995-02-03 | 1997-02-11 | Tchao; Ruy | Chemotaxis assay procedure |
WO1996027757A1 (en) * | 1995-03-03 | 1996-09-12 | Minnesota Mining And Manufacturing Company | Light directing film having variable height structured surface and light directing article constructed therefrom |
US5690894A (en) * | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5598300A (en) * | 1995-06-05 | 1997-01-28 | Board Of Regents, The University Of Texas System | Efficient bandpass reflection and transmission filters with low sidebands based on guided-mode resonance effects |
US6200737B1 (en) * | 1995-08-24 | 2001-03-13 | Trustees Of Tufts College | Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure |
EP0795121B1 (en) * | 1995-09-01 | 2003-11-12 | Paul Scherrer Institut | Process and device for measuring light beams |
GB9518429D0 (en) * | 1995-09-08 | 1995-11-08 | Pharmacia Biosensor | A rapid method for providing kinetic and structural data in molecular interaction analysis |
US5814516A (en) * | 1995-10-13 | 1998-09-29 | Lockheed Martin Energy Systems, Inc. | Surface enhanced Raman gene probe and methods thereof |
US6174677B1 (en) * | 1995-10-13 | 2001-01-16 | Ut-Battelle, Llc | Advanced surface-enhanced Raman gene probe systems and methods thereof |
US5822486A (en) * | 1995-11-02 | 1998-10-13 | General Scanning, Inc. | Scanned remote imaging method and system and method of determining optimum design characteristics of a filter for use therein |
US5814524A (en) * | 1995-12-14 | 1998-09-29 | Trustees Of Tufts College | Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations |
GB9602542D0 (en) | 1996-02-08 | 1996-04-10 | Fisons Plc | Analytical device |
US5801390A (en) * | 1996-02-09 | 1998-09-01 | Nikon Corporation | Position-detection method and apparatus with a grating mark |
US5804453A (en) * | 1996-02-09 | 1998-09-08 | Duan-Jun Chen | Fiber optic direct-sensing bioprobe using a phase-tracking approach |
AU2038897A (en) * | 1996-03-27 | 1997-10-17 | British Telecommunications Public Limited Company | Optical diffraction grating |
US5821343A (en) | 1996-04-25 | 1998-10-13 | Medtronic Inc | Oxidative method for attachment of biomolecules to surfaces of medical devices |
IL118209A0 (en) * | 1996-05-09 | 1998-02-08 | Yeda Res & Dev | Active electro-optical wavelength-selective mirrors and active electro-optic wavelength-selective filters |
US6174497B1 (en) * | 1997-06-04 | 2001-01-16 | Euro-Celtique, S.A. | Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form |
AU3794097A (en) * | 1996-06-10 | 1998-01-07 | Holographic Lithography Systems, Inc. | Holographic patterning method and tool for production environments |
US5666197A (en) | 1996-08-21 | 1997-09-09 | Polaroid Corporation | Apparatus and methods employing phase control and analysis of evanescent illumination for imaging and metrology of subwavelength lateral surface topography |
WO1998009156A1 (en) | 1996-08-29 | 1998-03-05 | Novartis Ag | Optical chemical / biochemical sensor |
US5846843A (en) | 1996-11-18 | 1998-12-08 | The University Of Toledo | Sensor using long range surface plasmon resonance with diffraction double-grating |
US5922550A (en) * | 1996-12-18 | 1999-07-13 | Kimberly-Clark Worldwide, Inc. | Biosensing devices which produce diffraction images |
CA2277278A1 (en) * | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
WO1998037417A1 (en) * | 1997-02-20 | 1998-08-27 | The Regents Of The University Of California | Plasmon resonant particles, methods and apparatus |
US5864641A (en) * | 1997-04-11 | 1999-01-26 | F&S, Inc. | Optical fiber long period sensor having a reactive coating |
US6035089A (en) * | 1997-06-11 | 2000-03-07 | Lockheed Martin Energy Research Corporation | Integrated narrowband optical filter based on embedded subwavelength resonant grating structures |
US5955378A (en) | 1997-08-20 | 1999-09-21 | Challener; William A. | Near normal incidence optical assaying method and system having wavelength and angle sensitivity |
US5925878A (en) * | 1997-08-20 | 1999-07-20 | Imation Corp. | Diffraction anomaly sensor having grating coated with protective dielectric layer |
US6902703B2 (en) * | 1999-05-03 | 2005-06-07 | Ljl Biosystems, Inc. | Integrated sample-processing system |
US6128431A (en) * | 1997-10-08 | 2000-10-03 | The Regents Of The University Of California | High efficiency source coupler for optical waveguide illumination system |
US5994150A (en) | 1997-11-19 | 1999-11-30 | Imation Corp. | Optical assaying method and system having rotatable sensor disk with multiple sensing regions |
US6338968B1 (en) * | 1998-02-02 | 2002-01-15 | Signature Bioscience, Inc. | Method and apparatus for detecting molecular binding events |
US6210910B1 (en) * | 1998-03-02 | 2001-04-03 | Trustees Of Tufts College | Optical fiber biosensor array comprising cell populations confined to microcavities |
US6054047A (en) * | 1998-03-27 | 2000-04-25 | Synsorb Biotech, Inc. | Apparatus for screening compound libraries |
DE19814811C1 (en) * | 1998-04-02 | 1999-08-05 | Inst Physikalische Hochtech Ev | Arrangement for surface plasmon resonance spectroscopy |
NL1008934C2 (en) | 1998-04-20 | 1999-10-21 | Univ Twente | Integrated optical light guide device. |
WO1999054784A1 (en) * | 1998-04-21 | 1999-10-28 | University Of Connecticut | Free-form nanofabrication using multi-photon excitation |
US5998298A (en) | 1998-04-28 | 1999-12-07 | Sandia Corporation | Use of chemical-mechanical polishing for fabricating photonic bandgap structures |
TW460758B (en) * | 1998-05-14 | 2001-10-21 | Holographic Lithography System | A holographic lithography system for generating an interference pattern suitable for selectively exposing a photosensitive material |
US6346376B1 (en) * | 1998-06-03 | 2002-02-12 | Centre Suisse D'electronique Et De Mictotechnique Sa | Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes |
US5986762A (en) | 1998-06-15 | 1999-11-16 | Imation Corp. | Optical sensor having optimized surface profile |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US6684007B2 (en) * | 1998-10-09 | 2004-01-27 | Fujitsu Limited | Optical coupling structures and the fabrication processes |
US6320991B1 (en) | 1998-10-16 | 2001-11-20 | Imation Corp. | Optical sensor having dielectric film stack |
AU1524500A (en) | 1998-11-13 | 2000-06-05 | Leica Microsystems Inc. | Refractometer and method for qualitative and quantitative measurements |
US6579673B2 (en) * | 1998-12-17 | 2003-06-17 | Kimberly-Clark Worldwide, Inc. | Patterned deposition of antibody binding protein for optical diffraction-based biosensors |
US6303179B1 (en) | 1999-02-08 | 2001-10-16 | Medtronic, Inc | Method for attachment of biomolecules to surfaces through amine-functional groups |
EP1031828B1 (en) | 1999-02-25 | 2006-09-13 | C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa | Integrated-optical sensor and method for integrated-optically sensing a substance |
JP2003501067A (en) | 1999-06-02 | 2003-01-14 | トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Compositions and methods useful for the production of recombinant viruses requiring helper virus |
US6332663B1 (en) | 1999-06-16 | 2001-12-25 | Xerox Corporation | Methods and apparatus for marking images and obtaining image data using a single marking engine platform |
US6771376B2 (en) | 1999-07-05 | 2004-08-03 | Novartis Ag | Sensor platform, apparatus incorporating the platform, and process using the platform |
EP1192448B1 (en) * | 1999-07-05 | 2006-09-27 | Novartis AG | Process of using a sensor platform |
CA2378180A1 (en) | 1999-07-12 | 2001-01-18 | Aztec Systems, Inc. | Electro-optic device allowing wavelength tuning |
DE69909480T2 (en) | 1999-09-15 | 2004-04-15 | Csem Centre Suisse D'electronique Et De Microtechnique S.A. | Integrated optical sensor |
US6376177B1 (en) | 1999-10-06 | 2002-04-23 | Virtual Pro, Inc. | Apparatus and method for the analysis of nucleic acids hybridization on high density NA chips |
US20050074825A1 (en) * | 1999-10-25 | 2005-04-07 | Ying Luo | Tankyrase H, compositions involved in the cell cycle and methods of use |
KR100390875B1 (en) * | 1999-10-27 | 2003-07-10 | (주)해빛정보 | Optical Phase Grating low pass filter |
US7167615B1 (en) * | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
FR2801977B1 (en) * | 1999-12-02 | 2002-05-17 | Commissariat Energie Atomique | AMPLIFICATION OF A FLUORESCENCE SIGNAL EMITTED BY A SURFACIC SAMPLE |
JP3886382B2 (en) | 2000-02-16 | 2007-02-28 | ウイスコンシン アラムニ リサーチ ファンデーション | Method and apparatus for detecting microscopic pathogens |
ATE469350T1 (en) | 2000-02-16 | 2010-06-15 | Wisconsin Alumni Res Found | BIOCHEMICAL BLOCKING LAYER FOR LIQUID CRYSTAL |
WO2001071410A2 (en) * | 2000-03-17 | 2001-09-27 | Zograph, Llc | High acuity lens system |
US6639674B2 (en) | 2000-03-28 | 2003-10-28 | Board Of Regents, The University Of Texas System | Methods and apparatus for polarized reflectance spectroscopy |
JP4812223B2 (en) * | 2000-06-02 | 2011-11-09 | バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Kit and method for multi-analyte determination |
US6449097B1 (en) * | 2000-06-05 | 2002-09-10 | Lightchip, Inc. | Diffraction grating for wavelength division multiplexing/demultiplexing devices |
US7399599B2 (en) | 2000-07-10 | 2008-07-15 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
CA2418871A1 (en) * | 2000-08-18 | 2002-02-28 | Lattice Intellectual Property Limited | Method and apparatus for detecting chemical contamination |
US7142296B2 (en) | 2000-10-30 | 2006-11-28 | Sru Biosystems, Inc. | Method and apparatus for detecting biomolecular interactions |
US6870624B2 (en) * | 2000-10-30 | 2005-03-22 | Coho Holdings Llc | Optical wavelength resonant device for chemical sensing |
US7202076B2 (en) * | 2000-10-30 | 2007-04-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US7175980B2 (en) * | 2000-10-30 | 2007-02-13 | Sru Biosystems, Inc. | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities |
US7575939B2 (en) * | 2000-10-30 | 2009-08-18 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7118710B2 (en) | 2000-10-30 | 2006-10-10 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US7371562B2 (en) * | 2000-10-30 | 2008-05-13 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
US7615339B2 (en) | 2000-10-30 | 2009-11-10 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
US6951715B2 (en) | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7264973B2 (en) * | 2000-10-30 | 2007-09-04 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant optical biosensor |
US7217574B2 (en) * | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
US20030113766A1 (en) * | 2000-10-30 | 2003-06-19 | Sru Biosystems, Llc | Amine activated colorimetric resonant biosensor |
US7023544B2 (en) | 2000-10-30 | 2006-04-04 | Sru Biosystems, Inc. | Method and instrument for detecting biomolecular interactions |
US7524625B2 (en) | 2000-10-30 | 2009-04-28 | Sru Biosystems, Inc. | Real time binding analysis of antigens on a biosensor surface |
US7070987B2 (en) | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
US20030092075A1 (en) * | 2000-10-30 | 2003-05-15 | Sru Biosystems, Llc | Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors |
US7306827B2 (en) * | 2000-10-30 | 2007-12-11 | Sru Biosystems, Inc. | Method and machine for replicating holographic gratings on a substrate |
US7153702B2 (en) | 2000-10-30 | 2006-12-26 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
US7101660B2 (en) * | 2000-10-30 | 2006-09-05 | Sru Biosystems, Inc. | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces |
US7300803B2 (en) * | 2000-10-30 | 2007-11-27 | Sru Biosystems, Inc. | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor |
US7033821B2 (en) * | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | Device for monitoring cell motility in real-time |
US7033819B2 (en) * | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | System for monitoring cell motility in real-time |
US6893836B2 (en) * | 2000-11-29 | 2005-05-17 | Picoliter Inc. | Spatially directed ejection of cells from a carrier fluid |
US6661952B2 (en) * | 2001-05-04 | 2003-12-09 | Ut Battelle, Llc | Sub-wavelength efficient polarization filter (SWEP filter) |
EP1499885B1 (en) | 2001-08-01 | 2009-10-21 | Cellomics, Inc. | Novel fusion proteins and assays for molecular binding |
US6748138B2 (en) * | 2001-09-14 | 2004-06-08 | Fibera, Inc. | Optical grating fabrication |
AU2002367539A1 (en) * | 2001-11-07 | 2003-09-16 | Auburn University | Phage ligand sensor devices and uses thereof |
US6982171B2 (en) * | 2002-03-12 | 2006-01-03 | Surface Logix, Inc. | Cell motility and chemotaxis test device and methods of using same |
CA2486812A1 (en) * | 2002-05-22 | 2004-05-21 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
NZ542784A (en) * | 2002-08-19 | 2008-07-31 | Astrazeneca Ab | Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof |
US7927822B2 (en) | 2002-09-09 | 2011-04-19 | Sru Biosystems, Inc. | Methods for screening cells and antibodies |
US7309614B1 (en) | 2002-12-04 | 2007-12-18 | Sru Biosystems, Inc. | Self-referencing biodetection method and patterned bioassays |
US7497992B2 (en) | 2003-05-08 | 2009-03-03 | Sru Biosystems, Inc. | Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers |
US8298780B2 (en) | 2003-09-22 | 2012-10-30 | X-Body, Inc. | Methods of detection of changes in cells |
JP2007510928A (en) | 2003-11-06 | 2007-04-26 | エス アール ユー バイオシステムズ,インコーポレイテッド | High density amine functionalized surface |
US6990259B2 (en) | 2004-03-29 | 2006-01-24 | Sru Biosystems, Inc. | Photonic crystal defect cavity biosensor |
US20060003372A1 (en) | 2004-06-28 | 2006-01-05 | Sru Biosystems, Inc. | Integration of direct binding label-free biosensors with mass spectrometry for functional and structural characterization of molecules |
DE102004052510A1 (en) | 2004-10-21 | 2006-04-27 | Wilhelm Stahlecker Gmbh | Air jet spinning machine |
NZ562794A (en) | 2005-04-12 | 2010-07-30 | Sru Biosystems Inc | Proteolipid membrane & lipid membrane biosensor using a titanium surface |
US7197198B2 (en) | 2005-06-23 | 2007-03-27 | Sru Biosystems, Inc. | Biosensor substrate structure for reducing the effects of optical interference |
US7162125B1 (en) | 2005-06-23 | 2007-01-09 | Sru Biosystems, Inc. | Optimized grating based biosensor and substrate combination |
US7521769B2 (en) | 2005-07-08 | 2009-04-21 | Sru Biosystems, Inc. | Photonic crystal biosensor structure and fabrication method |
US7479404B2 (en) | 2005-07-08 | 2009-01-20 | The Board Of Trustees Of The University Of Illinois | Photonic crystal biosensor structure and fabrication method |
US7483127B1 (en) | 2005-08-08 | 2009-01-27 | Sru Biosystems, Inc. | Method and apparatus for generating an image of biomolecular sensor target area |
KR101006793B1 (en) | 2005-08-11 | 2011-01-10 | 에스알유 바이오시스템즈, 인코포레이티드 | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
US7790406B2 (en) | 2005-08-11 | 2010-09-07 | Sru Biosystems, Inc | Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor |
US7756365B2 (en) | 2006-07-07 | 2010-07-13 | University Of Illinois | Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio |
AU2007313830A1 (en) | 2006-10-31 | 2008-05-08 | Sru Biosystems, Inc. | Method for blocking non-specific protein binding on a functionalized surface |
US7531786B2 (en) | 2006-11-09 | 2009-05-12 | The Board Of Trustees Of The Universiy Of Illinois | Photonic crystal sensors with integrated fluid containment structure |
US7628085B2 (en) | 2006-11-17 | 2009-12-08 | Sru Biosystems, Inc. | Simultaneous aspirator and dispenser for multiwell plates and similar devices |
US7497318B2 (en) | 2007-03-07 | 2009-03-03 | Chun-Wei Lin | Conveying and stacking device for corrugated boards |
US20080240543A1 (en) | 2007-03-30 | 2008-10-02 | Wolfgang Ernst Gustav Budach | Calibration and normalization method for biosensors |
CA2683082A1 (en) | 2007-04-19 | 2008-10-30 | Sru Biosystems, Inc. | Method for employing a biosensor to detect small molecules that bind directly to immobilized targets |
US9134307B2 (en) | 2007-07-11 | 2015-09-15 | X-Body, Inc. | Method for determining ion channel modulating properties of a test reagent |
US8268637B2 (en) | 2008-01-11 | 2012-09-18 | The Board Of Trustees Of The University Of Illinois | Label-free biosensors based upon distributed feedback laser |
US8257936B2 (en) | 2008-04-09 | 2012-09-04 | X-Body Inc. | High resolution label free analysis of cellular properties |
US20100015721A1 (en) | 2008-06-04 | 2010-01-21 | Sru Biosystems, Inc. | Detection of Promiscuous Small Submicrometer Aggregates |
US20100008826A1 (en) | 2008-07-10 | 2010-01-14 | Sru Biosystems, Inc. | Biosensors featuring confinement of deposited material and intra-well self-referencing |
JP2011527573A (en) | 2008-07-11 | 2011-11-04 | エス アール ユー バイオシステムズ,インコーポレイテッド | Methods for identifying regulators of ion channels |
CA2748946A1 (en) | 2009-02-02 | 2010-08-05 | Sru Biosystems, Inc. | Efficient optical arrangement for illumination and detection of label-free biosensors and method to reduce interference fringes in label-free imaging |
-
2001
- 2001-08-15 US US09/929,957 patent/US7118710B2/en not_active Expired - Fee Related
- 2001-08-15 US US09/930,352 patent/US7094595B2/en not_active Expired - Lifetime
- 2001-10-23 US US10/415,037 patent/US7435385B2/en active Active
- 2001-10-23 AU AU2002249786A patent/AU2002249786B2/en not_active Ceased
- 2001-10-23 WO PCT/US2001/050723 patent/WO2002059602A2/en active Application Filing
- 2001-10-23 WO PCT/US2001/045455 patent/WO2002061429A2/en active Application Filing
- 2001-10-23 EP EP10185633A patent/EP2402739A1/en not_active Withdrawn
- 2001-10-23 JP JP2002561944A patent/JP4202140B2/en not_active Expired - Fee Related
- 2001-10-23 AU AU2002246885A patent/AU2002246885A1/en not_active Abandoned
- 2001-10-23 CA CA2427689A patent/CA2427689C/en not_active Expired - Fee Related
- 2001-10-23 EP EP01998024A patent/EP1337847A1/en not_active Withdrawn
-
2004
- 2004-11-12 US US10/988,414 patent/US7422891B2/en not_active Expired - Lifetime
-
2005
- 2005-08-29 US US11/214,396 patent/US8101423B2/en not_active Expired - Fee Related
-
2008
- 2008-08-14 JP JP2008208966A patent/JP2009025312A/en active Pending
- 2008-08-14 JP JP2008208969A patent/JP2008309799A/en active Pending
- 2008-12-02 US US12/326,237 patent/US20090148955A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2009025312A (en) | 2009-02-05 |
US20060030033A1 (en) | 2006-02-09 |
EP1337847A1 (en) | 2003-08-27 |
US20020168295A1 (en) | 2002-11-14 |
WO2002061429A2 (en) | 2002-08-08 |
AU2002246885A1 (en) | 2002-08-06 |
CA2427689C (en) | 2012-01-24 |
WO2002061429A8 (en) | 2003-05-15 |
WO2002059602A3 (en) | 2003-01-30 |
JP2004529324A (en) | 2004-09-24 |
US20040132172A1 (en) | 2004-07-08 |
JP2008309799A (en) | 2008-12-25 |
US20020127565A1 (en) | 2002-09-12 |
US8101423B2 (en) | 2012-01-24 |
US20050227374A1 (en) | 2005-10-13 |
EP2402739A1 (en) | 2012-01-04 |
WO2002059602A2 (en) | 2002-08-01 |
US7422891B2 (en) | 2008-09-09 |
US7435385B2 (en) | 2008-10-14 |
AU2002249786B2 (en) | 2006-03-30 |
US7094595B2 (en) | 2006-08-22 |
US7118710B2 (en) | 2006-10-10 |
US20090148955A1 (en) | 2009-06-11 |
JP4202140B2 (en) | 2008-12-24 |
CA2427689A1 (en) | 2002-08-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002059602A8 (en) | A label-free high-throughput optical technique for detecting biomolecular interactions | |
WO2003064995A3 (en) | A guided mode resonant filter biosensor using a linear grating surface structure | |
AU2884401A (en) | Photothermic transducing spectroscopic analyzer | |
AU2001288293A1 (en) | Scannable barcode display and methods for using the same | |
AU2002367180A1 (en) | Concentration measuring method | |
AU2001256755A1 (en) | Biosensor and method for manufacturing the same | |
AU2003207980A1 (en) | Changing the temperature of a liquid sample and a receptacle useful therefor | |
AU2002212975A1 (en) | Methods of altering the resonance of waveguide micro-resonators | |
HK1051403A1 (en) | Devices for analyte concentration determination and methods of manufacturing and using the same | |
AU2002330406A1 (en) | Biosensing instrument and method and identifying device having biosensing function | |
AU2002231189A1 (en) | Optical bio-discs and methods relating thereto | |
AU2002243369A1 (en) | Polirized light sources and methods for making the same | |
AU2001271937A1 (en) | Apparatus and method for evanescent light fluoroassays | |
AU2690701A (en) | Spectroscopic probe | |
AU2003244812A1 (en) | Fluid analysis using photonic crystal waveguide | |
AU2002248476A1 (en) | Optimized defects in phonotic band-gap waveguides | |
AU2001224043A1 (en) | Product having glass layer and method for assessing the same | |
AU2003224085A1 (en) | Waveguide in porous substrates | |
AU2002216982A1 (en) | Reverse symmetry waveguide for optical biosensing | |
AU2001241172A1 (en) | Optical fiber and method for manufacturing the same | |
AU2002335663A1 (en) | Methods and devices for detecting cell-cell interactions | |
AU2002212184A1 (en) | Methods and reagents for protease inhibition | |
AU3386401A (en) | Fluid sample receptacle | |
AU2001230484A1 (en) | Method for the preparation of stable and reusable biosensing granules | |
AU2002325843A1 (en) | Method for determining the interaction between keratinocytes and neurons |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
WSNC | Later publication of a supplementary international search report together with a suppl. search report established by non-competent authority | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
WWE | Wipo information: entry into national phase |
Ref document number: 10415037 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: JP |