WO2002059602A8 - A label-free high-throughput optical technique for detecting biomolecular interactions - Google Patents

A label-free high-throughput optical technique for detecting biomolecular interactions

Info

Publication number
WO2002059602A8
WO2002059602A8 PCT/US2001/050723 US0150723W WO02059602A8 WO 2002059602 A8 WO2002059602 A8 WO 2002059602A8 US 0150723 W US0150723 W US 0150723W WO 02059602 A8 WO02059602 A8 WO 02059602A8
Authority
WO
WIPO (PCT)
Prior art keywords
label
biomolecular interactions
free high
optical technique
detecting biomolecular
Prior art date
Application number
PCT/US2001/050723
Other languages
French (fr)
Other versions
WO2002059602A3 (en
WO2002059602A2 (en
Inventor
Brian T Cunningham
Douglas Hobbs
Jane Pepper
Bo Lin
Peter Li
Homer Pien
Original Assignee
Sru Biosystems Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27399745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2002059602(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sru Biosystems Llc filed Critical Sru Biosystems Llc
Priority to US10/415,037 priority Critical patent/US7435385B2/en
Priority to AU2002246885A priority patent/AU2002246885A1/en
Publication of WO2002059602A2 publication Critical patent/WO2002059602A2/en
Publication of WO2002059602A3 publication Critical patent/WO2002059602A3/en
Publication of WO2002059602A8 publication Critical patent/WO2002059602A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4788—Diffraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/18—Diffraction gratings
    • G02B5/1809—Diffraction gratings with pitch less than or comparable to the wavelength
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
PCT/US2001/050723 2000-10-30 2001-10-23 A label-free high-throughput optical technique for detecting biomolecular interactions WO2002059602A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/415,037 US7435385B2 (en) 2000-10-30 2001-10-23 Label-free high-throughput optical technique for detecting biomolecular interactions
AU2002246885A AU2002246885A1 (en) 2000-10-30 2001-10-23 A label-free high-throughput optical technique for detecting biomolecular interactions

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24431200P 2000-10-30 2000-10-30
US60/244,312 2000-10-30
US28331401P 2001-04-12 2001-04-12
US60/283,314 2001-04-12
US30302801P 2001-07-03 2001-07-03
US60/303,028 2001-07-03

Publications (3)

Publication Number Publication Date
WO2002059602A2 WO2002059602A2 (en) 2002-08-01
WO2002059602A3 WO2002059602A3 (en) 2003-01-30
WO2002059602A8 true WO2002059602A8 (en) 2003-03-20

Family

ID=27399745

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/045455 WO2002061429A2 (en) 2000-10-30 2001-10-23 A label-free high-throughput optical technique for detecting biomolecular interactions
PCT/US2001/050723 WO2002059602A2 (en) 2000-10-30 2001-10-23 A label-free high-throughput optical technique for detecting biomolecular interactions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045455 WO2002061429A2 (en) 2000-10-30 2001-10-23 A label-free high-throughput optical technique for detecting biomolecular interactions

Country Status (6)

Country Link
US (6) US7094595B2 (en)
EP (2) EP2402739A1 (en)
JP (3) JP4202140B2 (en)
AU (2) AU2002246885A1 (en)
CA (1) CA2427689C (en)
WO (2) WO2002061429A2 (en)

Families Citing this family (241)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7754439B2 (en) * 2003-06-12 2010-07-13 Accupath Diagnostic Laboratories, Inc. Method and system for the analysis of high density cells samples
JP4999249B2 (en) 2000-03-22 2012-08-15 アクセラ インコーポレーテッド Multiple analyte assay method and assay apparatus
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7875434B2 (en) 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7524625B2 (en) 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
AUPR378001A0 (en) * 2001-03-16 2001-04-12 Proteome Systems Ltd Protein chip
US20050019942A1 (en) * 2001-03-16 2005-01-27 Proteome Systems Ltd. Array-based biomolecule analysis
US6862398B2 (en) * 2001-03-30 2005-03-01 Texas Instruments Incorporated System for directed molecular interaction in surface plasmon resonance analysis
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US7842246B2 (en) 2001-06-29 2010-11-30 Meso Scale Technologies, Llc Assay plates, reader systems and methods for luminescence test measurements
WO2003014711A1 (en) * 2001-08-07 2003-02-20 Mitsubishi Chemical Corporation Surface plasmon resonance sensor chip, and sample analysis method and analysis apparatus using the same
CA2743332A1 (en) * 2001-09-13 2003-03-20 Axela Inc. Method and apparatus for assay based on light diffraction
US6908678B2 (en) * 2002-01-18 2005-06-21 Advanced Gene Technology, Corp. Plastic slides for the fabrication of biochips
US7428367B2 (en) * 2002-10-17 2008-09-23 Brilliant Film Llc Light control devices and methods of making same
US7345824B2 (en) * 2002-03-26 2008-03-18 Trivium Technologies, Inc. Light collimating device
US7074311B1 (en) 2002-05-08 2006-07-11 Sru Biosystems Inc. Biosensor electrophoresis
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
CA2498906A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Diffraction grating-based optical identification element
US20040062682A1 (en) * 2002-09-30 2004-04-01 Rakow Neal Anthony Colorimetric sensor
US7449146B2 (en) * 2002-09-30 2008-11-11 3M Innovative Properties Company Colorimetric sensor
JP3786073B2 (en) 2002-10-10 2006-06-14 株式会社日立製作所 Biochemical sensor kit and measuring device
CN1717581A (en) 2002-10-28 2006-01-04 华盛顿大学 Wavelength tunable surface plasmon resonance sensor
US20040091397A1 (en) * 2002-11-07 2004-05-13 Corning Incorporated Multiwell insert device that enables label free detection of cells and other objects
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7027163B2 (en) * 2003-01-24 2006-04-11 General Dynamics Advanced Information Systems, Inc. Grating sensor
JP4295536B2 (en) * 2003-03-25 2009-07-15 株式会社リコー Image forming apparatus
WO2005012886A1 (en) * 2003-03-27 2005-02-10 Corning Incorporated Label-free evanescent-field detection of biological and chemical agents
US7294360B2 (en) 2003-03-31 2007-11-13 Planar Systems, Inc. Conformal coatings for micro-optical elements, and method for making the same
US7497992B2 (en) * 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US7292333B2 (en) * 2003-06-24 2007-11-06 Corning Incorporated Optical interrogation system and method for 2-D sensor arrays
US7057720B2 (en) * 2003-06-24 2006-06-06 Corning Incorporated Optical interrogation system and method for using same
US20050018944A1 (en) * 2003-07-25 2005-01-27 Mozdy Eric J. Polarization modulation interrogation of grating-coupled waveguide sensors
US6985664B2 (en) * 2003-08-01 2006-01-10 Corning Incorporated Substrate index modification for increasing the sensitivity of grating-coupled waveguides
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
US20050070027A1 (en) 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
CA2544836A1 (en) * 2003-11-06 2005-05-26 Guo Bin Wang High-density amine-functionalized surface
US20050148063A1 (en) * 2003-12-24 2005-07-07 Cracauer Raymond F. Disposable reaction vessel with integrated optical elements
US6990259B2 (en) * 2004-03-29 2006-01-24 Sru Biosystems, Inc. Photonic crystal defect cavity biosensor
US7262856B2 (en) * 2004-05-25 2007-08-28 Hobbs Douglas S Microstructured optical device for remote chemical sensing
US7239395B2 (en) * 2004-05-27 2007-07-03 Corning Incorporated Optical interrogation systems with reduced parasitic reflections and a method for filtering parasitic reflections
US7203386B2 (en) * 2004-09-21 2007-04-10 Corning Incorporated Self-referencing waveguide grating sensors
US7524672B2 (en) * 2004-09-22 2009-04-28 Sandia Corporation Microfluidic microarray systems and methods thereof
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
CA2584824A1 (en) * 2004-10-22 2006-05-04 Vanderbilt University On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes
US7136550B2 (en) * 2004-10-28 2006-11-14 Corning Incorporated Single-fiber launch/receive system for biosensing applications
US7285420B2 (en) * 2004-11-18 2007-10-23 Corning Incorporated System and method for self-referencing a sensor in a micron-sized deep flow chamber
US20060110594A1 (en) * 2004-11-24 2006-05-25 Frutos Anthony G Polymer-coated substrates for binding biomolecules and methods of making and using thereof
US7629173B2 (en) * 2004-12-29 2009-12-08 Corning Incorporated Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors
US20060141527A1 (en) * 2004-12-29 2006-06-29 Caracci Stephen J Method for creating a reference region and a sample region on a biosensor and the resulting biosensor
US7604984B2 (en) * 2004-12-29 2009-10-20 Corning Incorporated Spatially scanned optical reader system and method for using same
US7349080B2 (en) * 2004-12-30 2008-03-25 Corning Incorporated Label-independent detection of unpurified analytes
US7445887B2 (en) * 2005-01-07 2008-11-04 Fortebio, Inc. Enzyme activity measurements using bio-layer interferometry
US7405831B2 (en) * 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7346233B2 (en) * 2005-02-14 2008-03-18 Corning Incorporated Single mode (SM) fiber optical reader system and method for interrogating resonant waveguide-grating sensor(s)
US7454094B2 (en) * 2005-02-14 2008-11-18 Corning Incorporated Optical reader system and method that uses non-coherent illumination and angular filtering to interrogate a label independent biosensor
WO2006108183A2 (en) 2005-04-05 2006-10-12 Corning Incorporated Label free biosensors and cells
US20060223051A1 (en) * 2005-04-05 2006-10-05 Ye Fang System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors
US20060223111A1 (en) * 2005-04-05 2006-10-05 Chow Kai C Biosensor system that enables spectral multiplexing
US7871811B2 (en) * 2005-04-07 2011-01-18 Corning Incorporated Method for eliminating crosstalk between waveguide grating-based biosensors located in a microplate and the resulting microplate
ATE475886T1 (en) * 2005-04-12 2010-08-15 Sru Biosystems Inc PROTEOLIPID MEMBRANE AND LIPID MEMBRANE BIOSENSOR
US20060262250A1 (en) * 2005-05-18 2006-11-23 Hobbs Douglas S Microstructured optical device for polarization and wavelength filtering
US20070081163A1 (en) * 2005-06-03 2007-04-12 Minhua Liang Method and apparatus for scanned beam microarray assay
US20070139653A1 (en) * 2005-06-07 2007-06-21 Guan Hann W MEMS Micromirror Surface Plasmon Resonance Biosensor and Method
US20100261288A1 (en) 2005-06-13 2010-10-14 Fortebio, Inc. Tip tray assembly for optical sensors
US7718326B2 (en) * 2005-06-17 2010-05-18 Vincent E Stenger Seamless stitching of patterns formed by interference lithography
US7162125B1 (en) * 2005-06-23 2007-01-09 Sru Biosystems, Inc. Optimized grating based biosensor and substrate combination
US7197198B2 (en) * 2005-06-23 2007-03-27 Sru Biosystems, Inc. Biosensor substrate structure for reducing the effects of optical interference
US7521769B2 (en) * 2005-07-08 2009-04-21 Sru Biosystems, Inc. Photonic crystal biosensor structure and fabrication method
US7479404B2 (en) 2005-07-08 2009-01-20 The Board Of Trustees Of The University Of Illinois Photonic crystal biosensor structure and fabrication method
CN101228446B (en) * 2005-07-20 2014-08-06 康宁股份有限公司 Label-free high throughput biomolecular screening system and method
US7483127B1 (en) 2005-08-08 2009-01-27 Sru Biosystems, Inc. Method and apparatus for generating an image of biomolecular sensor target area
US7790406B2 (en) * 2005-08-11 2010-09-07 Sru Biosystems, Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
CA2615217A1 (en) * 2005-08-11 2007-02-15 Sru Biosystems, Inc. Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
US7889347B2 (en) 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
WO2007075444A2 (en) * 2005-12-16 2007-07-05 Indiana University Research & Technology Corporation Sub-micron surface plasmon resonance sensor systems
US8355136B2 (en) 2005-12-16 2013-01-15 Indiana University Research And Technology Corporation Sub-micron surface plasmon resonance sensor systems
US7781203B2 (en) * 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
US7474396B2 (en) * 2006-01-17 2009-01-06 Hewlett-Packard Development Company, L.P. Raman spectroscopy system and method using a subwavelength resonant grating filter
JP2009527739A (en) * 2006-02-16 2009-07-30 パーデュー・リサーチ・ファウンデーション Improved quadrature interference detection with inline quadrature and antireflection
JP4365832B2 (en) * 2006-03-07 2009-11-18 株式会社日立製作所 Biochemical analysis cell, biochemical analysis kit and biochemical analysis device
US7854505B2 (en) * 2006-03-15 2010-12-21 The Board Of Trustees Of The University Of Illinois Passive and active photonic crystal structures and devices
US20070223866A1 (en) * 2006-03-22 2007-09-27 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Controllable electromagnetically responsive assembly of self resonant bodies
FR2900279B1 (en) * 2006-04-19 2008-06-06 Commissariat Energie Atomique MICRO-STRUCTURE SPECTRAL FILTER AND IMAGE SENSOR
US20070264155A1 (en) * 2006-05-09 2007-11-15 Brady Michael D Aerosol jet deposition method and system for creating a reference region/sample region on a biosensor
US7809441B2 (en) * 2006-05-17 2010-10-05 Cardiac Pacemakers, Inc. Implantable medical device with chemical sensor and related methods
US7767143B2 (en) 2006-06-27 2010-08-03 3M Innovative Properties Company Colorimetric sensors
EP2041554A2 (en) * 2006-07-07 2009-04-01 The Board of Trustees of the University of Illinois Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio
US8158374B1 (en) 2006-09-05 2012-04-17 Ridge Diagnostics, Inc. Quantitative diagnostic methods using multiple parameters
WO2008033535A2 (en) * 2006-09-14 2008-03-20 Fortebio, Inc. Amine-reactive biosensor
US7976217B2 (en) * 2006-09-15 2011-07-12 Corning Incorporated Screening system and method for analyzing a plurality of biosensors
US20080191604A1 (en) * 2006-09-27 2008-08-14 Evident Technologies Retro-emission systems comprising microlens arrays and luminescent emitters
JP2010508520A (en) * 2006-10-31 2010-03-18 エス アール ユー バイオシステムズ，インコーポレイテッド Method for blocking non-specific protein binding on functionalized surfaces
US7737392B2 (en) * 2006-11-09 2010-06-15 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
AU2007319975B2 (en) * 2006-11-09 2011-03-03 Sru Biosystems, Inc. Photonic crystal sensors with integrated fluid containment structure
US7628085B2 (en) * 2006-11-17 2009-12-08 Sru Biosystems, Inc. Simultaneous aspirator and dispenser for multiwell plates and similar devices
US7999440B2 (en) * 2006-11-27 2011-08-16 Bioscale, Inc. Micro-fabricated devices having a suspended membrane or plate structure
US20080230605A1 (en) * 2006-11-30 2008-09-25 Brian Weichel Process and apparatus for maintaining data integrity
KR100927590B1 (en) 2006-12-05 2009-11-23 한국전자통신연구원 Resonant Reflective Light Filter and Biosensor Using the Same
KR100899811B1 (en) * 2006-12-05 2009-05-27 한국전자통신연구원 Guided mode resonance filter including high refractive index organic material and optical biosensor having the same
GB2444962B (en) * 2006-12-22 2010-01-27 Univ Muenster Wilhelms Adaptive crystalline X-ray reflecting device
US7659968B2 (en) 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
US7599055B2 (en) * 2007-02-27 2009-10-06 Corning Incorporated Swept wavelength imaging optical interrogation system and method for using same
WO2008118934A1 (en) 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
CN100458444C (en) * 2007-03-28 2009-02-04 山东轻工业学院 Micro-pool array chip processing method capable of being as ultra microhole analytical plate
US20080240543A1 (en) * 2007-03-30 2008-10-02 Wolfgang Ernst Gustav Budach Calibration and normalization method for biosensors
US7869032B2 (en) * 2007-04-05 2011-01-11 The Board Of Trustees Of The University Of Illinois Biosensors with porous dielectric surface for fluorescence enhancement and methods of manufacture
WO2008130488A1 (en) * 2007-04-19 2008-10-30 Corning Incorporated Live-cell signals of pathogen intrusion and methods thereof
US20080299673A1 (en) * 2007-04-19 2008-12-04 Sru Biosystems, Inc. Method for Employing a Biosensor to Detect Small Molecules ("Fragments") that Bind Directly to Immobilized Protein Targets
WO2008136812A2 (en) * 2007-05-07 2008-11-13 The Board Of Trustees Of The University Of Illinois Fluorescence detection enhancement using photonic crystal extraction
US7835013B2 (en) * 2007-05-18 2010-11-16 Vanderbilt University Interferometric detection system and method
CA2693700A1 (en) 2007-07-11 2009-01-15 Sru Biosystems, Inc. Methods for identifying modulators of ion channels
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US7576333B2 (en) * 2007-08-01 2009-08-18 Corning Incorporated Optical interrogation system and method for using same
US20090309617A1 (en) * 2007-08-24 2009-12-17 Ye Fang Biosensor antibody functional mapping
US8445217B2 (en) 2007-09-20 2013-05-21 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
JP4597175B2 (en) * 2007-09-21 2010-12-15 株式会社日立ハイテクノロジーズ Analytical apparatus for detecting a target substance, analytical method, or device used in these analytical apparatus and analytical method
US20090093011A1 (en) * 2007-10-05 2009-04-09 Ye Fang Biosensors for ligand-directed functional selectivity
US8703428B2 (en) * 2007-10-06 2014-04-22 Corning Incorporated Single-cell label-free assay
US8426148B2 (en) 2007-10-06 2013-04-23 Corning Incorporated Label-free methods using a resonant waveguide grating biosensor to determine GPCR signaling pathways
US20090325211A1 (en) * 2007-10-06 2009-12-31 Ye Fang System and method for dual-detection of a cellular response
US7978893B2 (en) * 2007-10-12 2011-07-12 Corning Incorporated System and method for microplate image analysis
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
US20090181409A1 (en) * 2008-01-10 2009-07-16 Ye Fang Optical biosensor method for cell-cell interaction
US8226253B2 (en) 2008-02-27 2012-07-24 Lubart Neil D Concentrators for solar power generating systems
US8313898B2 (en) 2008-03-05 2012-11-20 Corning Incorporated Dual-target biosensor cell assays
US8759013B2 (en) 2008-03-05 2014-06-24 Corning Incorporated Dual-target biosensor cell assays
US8846575B2 (en) 2008-03-05 2014-09-30 Corning Incorporated High-throughput high-information content label-free cell biology screening methods
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
WO2009149285A1 (en) * 2008-06-04 2009-12-10 Sru Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
US20100008826A1 (en) * 2008-07-10 2010-01-14 Sru Biosystems, Inc. Biosensors featuring confinement of deposited material and intra-well self-referencing
US8384892B2 (en) 2008-10-03 2013-02-26 Board Of Trustees Of The University Of Illinois Surface enhanced raman spectroscopy on optical resonator (e.g., photonic crystal) surfaces
US8953159B2 (en) 2008-10-03 2015-02-10 The Board Of Trustees Of The University Of Illinois Surface enhanced raman spectroscopy nanodome biosensors and methods of manufacturing the same
JP5540000B2 (en) * 2008-10-15 2014-07-02 リッジ ダイアグノスティックス，インコーポレイテッド Human biomarker hypermapping of depressive disorder
US7999944B2 (en) * 2008-10-23 2011-08-16 Corning Incorporated Multi-channel swept wavelength optical interrogation system and method for using same
KR101065078B1 (en) 2008-11-05 2011-09-15 삼성전자주식회사 A substate for bio-chip and manufacturing method of the same
EP2356453A4 (en) * 2008-11-18 2012-08-15 Ridge Diagnostics Inc Metabolic syndrome and hpa axis biomarkers for major depressive disorder
US8094305B2 (en) * 2009-02-02 2012-01-10 Sru Biosystems, Inc. Efficient optical arrangement for illumination and detection of label-free biosensors and method to reduce interference fringes in label-free imaging
JPWO2010110415A1 (en) 2009-03-27 2012-10-04 株式会社村田製作所 Method for measuring characteristics of object to be measured, structure with diffraction phenomenon, and measuring apparatus
EP2417448A4 (en) * 2009-04-06 2012-10-24 Ridge Diagnostics Inc Biomarkers for monitoring treatment of neuropsychiatric diseases
US20100273185A1 (en) * 2009-04-27 2010-10-28 Sru Biosystems, Inc. Detection of Biased Agonist Activation
EP2246693A1 (en) 2009-04-29 2010-11-03 Karlsruher Institut für Technologie Optical element, method for proving the presence of substances and use of the optical element
DE102009019717A1 (en) 2009-05-05 2010-11-11 Karlsruher Institut für Technologie Method and use of an optical grating for detecting the presence of molecules
US20100291575A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc. Detection of Changes in Cell Populations and Mixed Cell Populations
WO2011017147A1 (en) * 2009-08-05 2011-02-10 Corning Incorporated Label-independent optical reader system and methods with optical scanning
JP5384648B2 (en) * 2009-08-21 2014-01-08 株式会社村田製作所 Method for measuring the characteristics of the object to be measured
US8593630B2 (en) * 2009-10-07 2013-11-26 The Board Of Trustees Of The University Of Illinois Discrete frequency spectroscopy and instrumentation
EP2529222A4 (en) * 2010-01-26 2013-10-09 Ridge Diagnostics Inc Multiple biomarker panels to stratify disease severity and monitor treatment of depression
US9151891B2 (en) * 2010-02-12 2015-10-06 The Regents Of The University Of California Metamaterial-based optical lenses
US20110207789A1 (en) * 2010-02-19 2011-08-25 Ye Fang Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents
JPWO2011111785A1 (en) 2010-03-10 2013-06-27 国立大学法人東京工業大学 Layer structure for measuring reflected light intensity, apparatus comprising layer structure for measuring reflected light, and method for measuring film thickness and / or mass and / or viscosity of thin film
US20110236911A1 (en) * 2010-03-18 2011-09-29 Fortebio, Inc. Precipitating Substrate for Bio-Layer Interferometry
KR20110106684A (en) * 2010-03-23 2011-09-29 삼성전자주식회사 Microarray package device and method for manufacturing the same
US20110237535A1 (en) * 2010-03-26 2011-09-29 Sru Biosystems, Inc. Use of Induced Pluripotent Cells and other Cells for Screening Compound Libraries
US8974651B2 (en) 2010-04-17 2015-03-10 C.C. Imex Illuminator for visualization of fluorophores
US8472031B2 (en) 2010-05-25 2013-06-25 Valerio Pruneri Apparatus and method for optical interrogation
US9638632B2 (en) 2010-06-11 2017-05-02 Vanderbilt University Multiplexed interferometric detection system and method
US8519490B2 (en) * 2010-08-09 2013-08-27 Omnivision Technologies, Inc. Backside stimulated sensor with background current manipulation
US8987841B2 (en) 2010-08-09 2015-03-24 Omnivision Technologies, Inc. Backside stimulated sensor with background current manipulation
EP2417910B1 (en) * 2010-08-11 2013-06-26 Roche Diagnostics GmbH Analytical test unit and test system
CN102045752B (en) * 2010-12-23 2015-09-16 中兴通讯股份有限公司 User media face tracking and device
WO2012104680A1 (en) * 2011-01-31 2012-08-09 Indian Institute Of Science Apparatus and methods for sensing or imaging using stacked thin films
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US9272126B2 (en) 2011-04-29 2016-03-01 The Board Of Trustees Of The University Of Illinois Photonic biosensors incorporated into tubing, methods of manufacture and instruments for analyzing the biosensors
KR101799521B1 (en) * 2011-05-24 2017-11-20 삼성전자 주식회사 Light modulator with photonic crystal and 3D image acquisition apparatus employing the same
JP2014532169A (en) * 2011-09-26 2014-12-04 シクパ ホルディング ソシエテ アノニムＳｉｃｐａ Ｈｏｌｄｉｎｇ Ｓａ Optical variable entity authentication apparatus and method
US9546219B2 (en) 2012-02-08 2017-01-17 North Carolina State University Treatment of allergic diseases with recombinant antibodies
WO2013128614A1 (en) * 2012-03-01 2013-09-06 日本精工株式会社 Target-material detection device and target-material detection method
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
US11181448B2 (en) 2012-11-06 2021-11-23 Biodot, Inc. Controlled printing of a cell sample for karyotyping
US8976359B2 (en) * 2012-12-15 2015-03-10 Board Of Trustees Of The University Of Alabama, For And On Behalf Of The University Of Alabama In Huntsville Nanostructure diffraction gratings for integrated spectroscopy and sensing
CN103398989B (en) * 2013-08-16 2015-05-20 中国科学院光电技术研究所 Chip-type surface plasma spectrometer
US9835587B2 (en) 2014-04-01 2017-12-05 C.C. Imex Electrophoresis running tank assembly
EP3137591A2 (en) * 2014-05-01 2017-03-08 King Abdullah University Of Science And Technology A microfluidic device that separates cells
JP2018506715A (en) 2015-01-23 2018-03-08 ヴァンダービルト ユニバーシティー Robust interferometer and method of use
JP6585728B2 (en) 2015-02-23 2019-10-02 リ−コール，インコーポレイティド Biopsy specimen fluorescence imaging apparatus and method
WO2016210340A1 (en) * 2015-06-26 2016-12-29 Li-Cor, Inc. Fluorescence biopsy specimen imager and methods
US10716500B2 (en) 2015-06-29 2020-07-21 Cardiac Pacemakers, Inc. Systems and methods for normalization of chemical sensor data based on fluid state changes
US10801956B2 (en) 2015-08-26 2020-10-13 Photonicsys Ltd. Resonant periodic structures and methods of using them as filters and sensors
US20170191020A1 (en) 2015-12-30 2017-07-06 Palo Alto Research Center Incorporated Thermochromic sensing devices, systems, and methods
US9963732B2 (en) 2015-12-30 2018-05-08 Palo Alto Research Center Incorporated Thermochromic sensing devices, systems, and methods
US10598554B2 (en) * 2015-12-30 2020-03-24 Palo Alto Research Center Incorporated Thermochromic sensing for nanocalorimetry
US10697892B2 (en) * 2016-01-26 2020-06-30 Danmarks Tekniske Universitet Cuvette and method for measuring refractive index in a spectrophotometer
US10627396B2 (en) 2016-01-29 2020-04-21 Vanderbilt University Free-solution response function interferometry
WO2017136187A2 (en) * 2016-02-01 2017-08-10 Micro Detect, Inc. Uv solid state detection and methods therefor
US10983275B2 (en) * 2016-03-21 2021-04-20 The Regents Of The University Of Colorado, A Body Corporate Method and apparatus for optical waveguide-to-semiconductor coupling for integrated photonic circuits
EP3446098A1 (en) 2016-04-21 2019-02-27 Li-Cor, Inc. Multimodality multi-axis 3-d imaging
GB201610647D0 (en) * 2016-06-17 2016-08-03 Univ York Improved sensor and associated methods
WO2017223378A1 (en) 2016-06-23 2017-12-28 Li-Cor, Inc. Complementary color flashing for multichannel image presentation
CA3041717A1 (en) 2016-11-09 2018-05-17 North Carolina State University Treatment of allergic diseases with chimeric protein
WO2018098162A1 (en) 2016-11-23 2018-05-31 Li-Cor, Inc. Motion-adaptive interactive imaging method
EP3551047A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
EP3616158A1 (en) 2017-04-25 2020-03-04 Li-Cor, Inc. Top-down and rotational side view biopsy specimen imager and methods
US20180315791A1 (en) * 2017-04-30 2018-11-01 Himax Technologies Limited Image sensor structure
CN108968976B (en) 2017-05-31 2022-09-13 心脏起搏器股份公司 Implantable medical device with chemical sensor
FR3067043B1 (en) * 2017-06-02 2021-06-25 Univ De Lille 1 Sciences Et Technologies OPTICAL DETECTION PROCESS
DE102017115922C5 (en) * 2017-07-14 2023-03-23 Precitec Gmbh & Co. Kg Method and device for measuring and setting a distance between a machining head and a workpiece and associated method for regulation
CN109381195B (en) 2017-08-10 2023-01-10 心脏起搏器股份公司 Systems and methods including electrolyte sensor fusion
CN109419515B (en) 2017-08-23 2023-03-24 心脏起搏器股份公司 Implantable chemical sensor with staged activation
CN109864746B (en) 2017-12-01 2023-09-29 心脏起搏器股份公司 Multimode analyte sensor for medical devices
CN109864747B (en) 2017-12-05 2023-08-25 心脏起搏器股份公司 Multimode analyte sensor optoelectronic interface
US11402669B2 (en) 2018-04-27 2022-08-02 Apple Inc. Housing surface with tactile friction features
CN112585083A (en) 2018-05-15 2021-03-30 杜兰教育基金委员会 Refractive index sensor and method
US11112827B2 (en) 2018-07-20 2021-09-07 Apple Inc. Electronic device with glass housing member
AU2019325342A1 (en) * 2018-08-24 2021-02-11 Zoetis Services Llc Microfluidic rotor device
KR102600016B1 (en) 2018-08-24 2023-11-09 조에티스 서비시즈 엘엘씨 microfluidic rotor device
AU2019325343A1 (en) 2018-08-24 2021-02-18 Zoetis Services Llc Methods for manufacturing a microfluidic rotor device
US11691912B2 (en) 2018-12-18 2023-07-04 Apple Inc. Chemically strengthened and textured glass housing member
CN109459813A (en) * 2018-12-26 2019-03-12 上海鲲游光电科技有限公司 A kind of planar optical waveguide based on two-dimensional grating
US11199929B2 (en) 2019-03-21 2021-12-14 Apple Inc. Antireflective treatment for textured enclosure components
CN110095416B (en) * 2019-04-29 2021-10-08 西北核技术研究所 Metal molten pool laser absorption rate distribution on-line measuring system and method
US11372137B2 (en) 2019-05-29 2022-06-28 Apple Inc. Textured cover assemblies for display applications
US11192823B2 (en) * 2019-06-05 2021-12-07 Apple Inc. Electronic devices including laser-textured glass cover members
US10827635B1 (en) 2019-06-05 2020-11-03 Apple Inc. Electronic device enclosure having a textured glass component
US11109500B2 (en) 2019-06-05 2021-08-31 Apple Inc. Textured glass component for an electronic device enclosure
FR3097050B1 (en) 2019-06-07 2021-08-27 Centre Nat Rech Scient Method and device for analyzing a sample, using a resonant support.
US11925456B2 (en) 2020-04-29 2024-03-12 Hyperspectral Corp. Systems and methods for screening asymptomatic virus emitters
CN111781672B (en) * 2020-07-28 2022-02-25 中国人民解放军国防科技大学 Two-dimensional single-core fiber grating and writing method thereof
US11897809B2 (en) 2020-09-02 2024-02-13 Apple Inc. Electronic devices with textured glass and glass ceramic components
CN113009609A (en) * 2021-03-01 2021-06-22 苏州大学 Volume grating calibration assembly, volume grating preparation device, calibration method and exposure method

Family Cites Families (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US457685A (en) * 1891-08-11 Guide for rolling-mills
US707987A (en) * 1901-07-26 1902-08-26 William C Beddow Lock-up for printers' forms.
US3100991A (en) * 1961-10-30 1963-08-20 Gen Electric Reversible hydraulic torque applier
US3689346A (en) 1970-09-29 1972-09-05 Rowland Dev Corp Method for producing retroreflective material
US3856604A (en) * 1971-09-24 1974-12-24 Konttorikoneteollisuus Oy Machine for selectively cutting and gluing address labels
US3916182A (en) 1972-08-21 1975-10-28 Western Electric Co Periodic dielectric waveguide filter
US3810688A (en) 1973-05-21 1974-05-14 A Ballman Optical waveguiding devices using monocrystalline materials of the sillenite family of bismuth oxides
US3856404A (en) 1973-06-06 1974-12-24 Phys Chem Res Corp Method and apparatus for measuring vapor pressure
US4009933A (en) 1975-05-07 1977-03-01 Rca Corporation Polarization-selective laser mirror
US4050895A (en) 1975-09-26 1977-09-27 Monsanto Research Corporation Optical analytical device, waveguide and method
US4668558A (en) 1978-07-20 1987-05-26 Minnesota Mining And Manufacturing Company Shaped plastic articles having replicated microstructure surfaces
US4576850A (en) 1978-07-20 1986-03-18 Minnesota Mining And Manufacturing Company Shaped plastic articles having replicated microstructure surfaces
US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US4240751A (en) 1978-11-09 1980-12-23 Akzona Incorporated Method and apparatus for specific binding substances
US4289371A (en) 1979-05-31 1981-09-15 Xerox Corporation Optical scanner using plane linear diffraction gratings on a rotating spinner
US4321057A (en) 1979-09-20 1982-03-23 Buckles Richard G Method for quantitative analysis using optical fibers
US4420502A (en) 1980-09-05 1983-12-13 Conley Kenneth E Apparatus and method for producing a flexible sheet material having a predetermined surface characteristic
GB2103786A (en) 1981-08-14 1983-02-23 Ici Plc Fibre optic sensor
US4608344A (en) * 1981-09-18 1986-08-26 Battelle Memorial Institute Method for the determination of species in solution with an optical wave-guide
USRE33064E (en) 1981-09-18 1989-09-19 Prutec Limited Method for the determination of species in solution with an optical wave-guide
FI74371C (en) 1982-06-04 1988-01-11 British Telecomm Optical transmission.
CA1237645A (en) 1982-12-21 1988-06-07 John H. Fisher Assay technique
US4536608A (en) * 1983-04-25 1985-08-20 Exxon Research And Engineering Co. Solar cell with two-dimensional hexagonal reflecting diffraction grating
US4652290A (en) 1983-07-05 1987-03-24 Motorola, Inc. Method for making optical channel waveguides and product manufactured thereby
GB2156970B (en) 1984-01-06 1987-09-16 Plessey Co Plc Optical detection of specific molecules
CA1231136A (en) 1984-06-13 1988-01-05 Ian A. Shanks Capillary action chemical test device
US4701008A (en) 1984-08-10 1987-10-20 Motorola, Inc. Optical waveguide including superstrate of niobium or silicon oxynitride and method of making same
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
US4650329A (en) 1984-11-29 1987-03-17 The United States Of America As Represented By The Secretary Of The Navy Optical 3-d signature device for detecting chemical agents
EP0184600B1 (en) 1984-12-10 1990-03-14 Prutec Limited Method for optically ascertaining parameters of species in a liquid analyte
GB8509491D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
CH670521A5 (en) 1985-05-29 1989-06-15 Oerlikon Buehrle Holding Ag Optical sensor detecting specific substances in material
CH669050A5 (en) 1985-05-29 1989-02-15 Oerlikon Buehrle Holding Ag Optical sensor detecting specific substances in material
WO1986007149A1 (en) 1985-05-29 1986-12-04 Kurt Tiefenthaler Optical sensor for selectively determining the presence of substances and the variation of the refraction index in the measured substances
USRE33084E (en) * 1985-11-13 1989-10-10 Intermittently operating pneumatic device for pumping solid-carrying liquids and slurries
US5148302A (en) * 1986-04-10 1992-09-15 Akihiko Nagano Optical modulation element having two-dimensional phase type diffraction grating
GB8618133D0 (en) * 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
US4876208A (en) 1987-01-30 1989-10-24 Yellowstone Diagnostics Corporation Diffraction immunoassay apparatus and method
GB8705649D0 (en) 1987-03-10 1987-04-15 Pa Consulting Services Assay sensor
US4888260A (en) * 1987-08-10 1989-12-19 Polaroid Corporation Volume phase reflection holograms and methods for fabricating them
US4999234A (en) 1987-08-10 1991-03-12 Polaroid Corporation Holographic optical data storage medium
GB8801807D0 (en) 1988-01-27 1988-02-24 Amersham Int Plc Biological sensors
NL8800219A (en) 1988-01-29 1989-08-16 Philips Nv ROTATABLE MAGNETIC UNIT FOR A MAGNETIC TAPE DEVICE.
US4952056A (en) 1988-05-17 1990-08-28 Entwicklungsgemeinschaft Asi Method of determining the autocollimation angle of a grating coupler
GB2220080A (en) 1988-06-24 1989-12-28 Marconi Gec Ltd Improvements in optical waveguides
US6235488B1 (en) 1988-09-29 2001-05-22 Agilent Technologies, Inc. Surface preparation for chemical-specific binding
SE8804074D0 (en) * 1988-11-10 1988-11-10 Pharmacia Ab SENSOR UNIT AND ITS USE IN BIOSENSOR SYSTEM
SE462454B (en) 1988-11-10 1990-06-25 Pharmacia Ab METHOD FOR USE IN BIOSENSORS
GB2227089A (en) 1989-01-11 1990-07-18 Plessey Co Plc An optical biosensor
US5175030A (en) 1989-02-10 1992-12-29 Minnesota Mining And Manufacturing Company Microstructure-bearing composite plastic articles and method of making
GB8916764D0 (en) 1989-07-21 1989-09-06 Sambles John R Surface plasmon optical sensor
US5156785A (en) 1991-07-10 1992-10-20 Cordis Corporation Extruded tubing and catheters having increased rotational stiffness
US5541057A (en) 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
WO1991013339A1 (en) 1990-03-02 1991-09-05 Fisons Plc Sample cell for use in chemical or biochemical assays
EP0455067B1 (en) 1990-05-03 2003-02-26 F. Hoffmann-La Roche Ag Micro-optical sensor
NZ238159A (en) * 1990-05-17 1992-03-26 Adeza Biomedical Corp Reflective biograting for diffraction immunoassays
US5478756A (en) 1990-07-24 1995-12-26 Fisons Plc Chemical sensor for detecting binding reactions
US5337183A (en) * 1991-02-01 1994-08-09 Yeda Research And Development Co. Ltd. Distributed resonant cavity light beam modulator
SE468188B (en) * 1991-04-08 1992-11-16 Stiftelsen Inst Foer Mikroelek METHOD FOR CONNECTING RADIATION IN AN INFRARED DETECTOR, APPLIED DEVICE
EP0538425B1 (en) * 1991-04-26 1996-11-27 Paul Scherrer Institut Process and device for determining quantities to be measured by means of an integrated optical sensor module
US5155785A (en) 1991-05-01 1992-10-13 At&T Bell Laboratories Optical fiber interconnection apparatus and method
GB9111912D0 (en) 1991-06-04 1991-07-24 Fisons Plc Analytical methods
GB2256477B (en) * 1991-06-07 1995-03-08 Marconi Gec Ltd An optical sensor
US5216680A (en) 1991-07-11 1993-06-01 Board Of Regents, The University Of Texas System Optical guided-mode resonance filter
US5170448A (en) 1992-01-06 1992-12-08 Motorola, Inc. Optical waveguide apparatus and method for partially collecting light
GB9200562D0 (en) 1992-01-11 1992-03-11 Fisons Plc Analytical device with polychromatic light source
US5268782A (en) 1992-01-16 1993-12-07 Minnesota Mining And Manufacturing Company Micro-ridged, polymeric liquid crystal display substrate and display device
US5494829A (en) * 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5413884A (en) 1992-12-14 1995-05-09 American Telephone And Telegraph Company Grating fabrication using electron beam lithography
US5615052A (en) 1993-04-16 1997-03-25 Bruce W. McCaul Laser diode/lens assembly
US5281343A (en) * 1993-04-20 1994-01-25 Ingersoll-Rand Company Vacuum filtration system and method of filtering pulp fibers from pulp slurry using the same
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
ES2102857T3 (en) 1993-06-11 1997-08-01 Minnesota Mining & Mfg REPRODUCTION TOOL MACHINED BY LASER.
US5475780A (en) 1993-06-17 1995-12-12 At&T Corp. Optical waveguiding component comprising a band-pass filter
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
GB9314991D0 (en) 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
ATE182502T1 (en) 1993-09-13 1999-08-15 Minnesota Mining & Mfg ABRASIVE ARTICLE, METHOD FOR MANUFACTURING THE SAME, METHOD FOR USING THE SAME FOR FINISHING, AND MANUFACTURING TOOL
US6042998A (en) 1993-09-30 2000-03-28 The University Of New Mexico Method and apparatus for extending spatial frequencies in photolithography images
US5691846A (en) 1993-10-20 1997-11-25 Minnesota Mining And Manufacturing Company Ultra-flexible retroreflective cube corner composite sheetings and methods of manufacture
US5559338A (en) * 1994-10-04 1996-09-24 Excimer Laser Systems, Inc. Deep ultraviolet optical imaging system for microlithography and/or microfabrication
US5955335A (en) 1994-10-08 1999-09-21 Foschungszentrum Julich GmbH Biomaterial immobilization on an Si3 N4 surface containing Si-NH2 groups with a heterobifunctional cross-linking agent
TW323341B (en) 1995-01-09 1997-12-21 Minnesota Mining & Mfg
US5601997A (en) * 1995-02-03 1997-02-11 Tchao; Ruy Chemotaxis assay procedure
US5606170A (en) 1995-02-03 1997-02-25 Research International, Inc. Multifunctional sensor system
CA2212223C (en) 1995-03-03 2007-03-20 David L. Wortman Light directing film having variable height structured surface and light directing article constructed therefrom
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5598300A (en) * 1995-06-05 1997-01-28 Board Of Regents, The University Of Texas System Efficient bandpass reflection and transmission filters with low sidebands based on guided-mode resonance effects
US6200737B1 (en) 1995-08-24 2001-03-13 Trustees Of Tufts College Photodeposition method for fabricating a three-dimensional, patterned polymer microstructure
EP0795121B1 (en) 1995-09-01 2003-11-12 Paul Scherrer Institut Process and device for measuring light beams
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US6174677B1 (en) 1995-10-13 2001-01-16 Ut-Battelle, Llc Advanced surface-enhanced Raman gene probe systems and methods thereof
US5814516A (en) 1995-10-13 1998-09-29 Lockheed Martin Energy Systems, Inc. Surface enhanced Raman gene probe and methods thereof
US5822486A (en) 1995-11-02 1998-10-13 General Scanning, Inc. Scanned remote imaging method and system and method of determining optimum design characteristics of a filter for use therein
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
GB9602542D0 (en) 1996-02-08 1996-04-10 Fisons Plc Analytical device
US5801390A (en) * 1996-02-09 1998-09-01 Nikon Corporation Position-detection method and apparatus with a grating mark
US5804453A (en) 1996-02-09 1998-09-08 Duan-Jun Chen Fiber optic direct-sensing bioprobe using a phase-tracking approach
JP2000508083A (en) * 1996-03-27 2000-06-27 ブリティッシュ・テレコミュニケーションズ・パブリック・リミテッド・カンパニー Optical diffraction grating
US5821343A (en) 1996-04-25 1998-10-13 Medtronic Inc Oxidative method for attachment of biomolecules to surfaces of medical devices
IL118209A0 (en) * 1996-05-09 1998-02-08 Yeda Res & Dev Active electro-optical wavelength-selective mirrors and active electro-optic wavelength-selective filters
US6174497B1 (en) * 1997-06-04 2001-01-16 Euro-Celtique, S.A. Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
WO1997047997A1 (en) 1996-06-10 1997-12-18 Holographic Lithography Systems, Inc. Holographic patterning method and tool for production environments
US5666197A (en) 1996-08-21 1997-09-09 Polaroid Corporation Apparatus and methods employing phase control and analysis of evanescent illumination for imaging and metrology of subwavelength lateral surface topography
EP0922214A1 (en) * 1996-08-29 1999-06-16 Novartis AG Optical chemical / biochemical sensor
US5846843A (en) 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
US5922550A (en) * 1996-12-18 1999-07-13 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images
CA2277278A1 (en) * 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
EP0979409B1 (en) * 1997-02-20 2006-12-27 The Regents of the University of California Plasmon resonant particles, methods and apparatus
US5864641A (en) 1997-04-11 1999-01-26 F&S, Inc. Optical fiber long period sensor having a reactive coating
US6035089A (en) 1997-06-11 2000-03-07 Lockheed Martin Energy Research Corporation Integrated narrowband optical filter based on embedded subwavelength resonant grating structures
US5955378A (en) 1997-08-20 1999-09-21 Challener; William A. Near normal incidence optical assaying method and system having wavelength and angle sensitivity
US5925878A (en) 1997-08-20 1999-07-20 Imation Corp. Diffraction anomaly sensor having grating coated with protective dielectric layer
US6902703B2 (en) * 1999-05-03 2005-06-07 Ljl Biosystems, Inc. Integrated sample-processing system
US6128431A (en) 1997-10-08 2000-10-03 The Regents Of The University Of California High efficiency source coupler for optical waveguide illumination system
US5994150A (en) 1997-11-19 1999-11-30 Imation Corp. Optical assaying method and system having rotatable sensor disk with multiple sensing regions
US6338968B1 (en) 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
US6210910B1 (en) * 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6054047A (en) * 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
DE19814811C1 (en) * 1998-04-02 1999-08-05 Inst Physikalische Hochtech Ev Arrangement for surface plasmon resonance spectroscopy
NL1008934C2 (en) 1998-04-20 1999-10-21 Univ Twente Integrated optical light guide device.
EP2133725B1 (en) 1998-04-21 2018-06-06 University of Connecticut Fabrication method for nanofabrication using multi-photon excitation
US5998298A (en) 1998-04-28 1999-12-07 Sandia Corporation Use of chemical-mechanical polishing for fabricating photonic bandgap structures
TW460758B (en) * 1998-05-14 2001-10-21 Holographic Lithography System A holographic lithography system for generating an interference pattern suitable for selectively exposing a photosensitive material
US6346376B1 (en) * 1998-06-03 2002-02-12 Centre Suisse D'electronique Et De Mictotechnique Sa Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
US5986762A (en) 1998-06-15 1999-11-16 Imation Corp. Optical sensor having optimized surface profile
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6684007B2 (en) * 1998-10-09 2004-01-27 Fujitsu Limited Optical coupling structures and the fabrication processes
US6320991B1 (en) * 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
AU1524500A (en) 1998-11-13 2000-06-05 Leica Microsystems Inc. Refractometer and method for qualitative and quantitative measurements
US6579673B2 (en) * 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
US6303179B1 (en) 1999-02-08 2001-10-16 Medtronic, Inc Method for attachment of biomolecules to surfaces through amine-functional groups
EP1031828B1 (en) 1999-02-25 2006-09-13 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Integrated-optical sensor and method for integrated-optically sensing a substance
CA2375098A1 (en) 1999-06-02 2000-12-14 Trustees Of The University Of Pennsylvania Compositions and methods useful for production of recombinant viruses which require helper viruses
US6332663B1 (en) 1999-06-16 2001-12-25 Xerox Corporation Methods and apparatus for marking images and obtaining image data using a single marking engine platform
KR100883079B1 (en) * 1999-07-05 2009-02-10 노파르티스 아게 Sensor platform, apparatus incorporating the platform, and process using the platform
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
WO2001004697A1 (en) 1999-07-12 2001-01-18 Coho Holdings, Llc Electro-optic device allowing wavelength tuning
ATE244883T1 (en) 1999-09-15 2003-07-15 Suisse Electronique Microtech INTEGRATED OPTICAL SENSOR
US6376177B1 (en) 1999-10-06 2002-04-23 Virtual Pro, Inc. Apparatus and method for the analysis of nucleic acids hybridization on high density NA chips
US20050074825A1 (en) * 1999-10-25 2005-04-07 Ying Luo Tankyrase H, compositions involved in the cell cycle and methods of use
KR100390875B1 (en) * 1999-10-27 2003-07-10 (주)해빛정보 Optical Phase Grating low pass filter
US7167615B1 (en) * 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
FR2801977B1 (en) 1999-12-02 2002-05-17 Commissariat Energie Atomique AMPLIFICATION OF A FLUORESCENCE SIGNAL EMITTED BY A SURFACIC SAMPLE
JP3886382B2 (en) 2000-02-16 2007-02-28 ウイスコンシン アラムニ リサーチ ファンデーション Method and apparatus for detecting microscopic pathogens
JP3512775B2 (en) 2000-02-16 2004-03-31 ウイスコンシン アラムニ リサーチ ファンデーション Biochemical blocking layer for liquid crystal assays
WO2001071410A2 (en) 2000-03-17 2001-09-27 Zograph, Llc High acuity lens system
US6639674B2 (en) 2000-03-28 2003-10-28 Board Of Regents, The University Of Texas System Methods and apparatus for polarized reflectance spectroscopy
JP4812223B2 (en) * 2000-06-02 2011-11-09 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Kit and method for multi-analyte determination
US6449097B1 (en) * 2000-06-05 2002-09-10 Lightchip, Inc. Diffraction grating for wavelength division multiplexing/demultiplexing devices
US6969449B2 (en) 2000-07-10 2005-11-29 Vertex Pharmaceuticals (San Diego) Llc Multi-well plate and electrode assemblies for ion channel assays
AU2001282276A1 (en) * 2000-08-18 2002-03-04 Lattice Intellectual Property Ltd. Method and apparatus for detecting chemical contamination
US7524625B2 (en) 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7070987B2 (en) 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7615339B2 (en) 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US6870624B2 (en) 2000-10-30 2005-03-22 Coho Holdings Llc Optical wavelength resonant device for chemical sensing
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7153702B2 (en) 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7033821B2 (en) * 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US7033819B2 (en) * 2000-11-08 2006-04-25 Surface Logix, Inc. System for monitoring cell motility in real-time
US6893836B2 (en) * 2000-11-29 2005-05-17 Picoliter Inc. Spatially directed ejection of cells from a carrier fluid
US6661952B2 (en) * 2001-05-04 2003-12-09 Ut Battelle, Llc Sub-wavelength efficient polarization filter (SWEP filter)
JP2005507650A (en) 2001-08-01 2005-03-24 セロミックス インコーポレイテッド Assays for novel fusion proteins and molecular binding
US6748138B2 (en) * 2001-09-14 2004-06-08 Fibera, Inc. Optical grating fabrication
AU2002367539A1 (en) * 2001-11-07 2003-09-16 Auburn University Phage ligand sensor devices and uses thereof
WO2003078565A1 (en) * 2002-03-12 2003-09-25 Surface Logix, Inc. Cell motility and chemotaxis test device and methods of using same
US7018838B2 (en) * 2002-05-22 2006-03-28 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
US7202343B2 (en) * 2002-08-19 2007-04-10 Abgenix, Inc. Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7497992B2 (en) 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
CA2544836A1 (en) 2003-11-06 2005-05-26 Guo Bin Wang High-density amine-functionalized surface
US6990259B2 (en) 2004-03-29 2006-01-24 Sru Biosystems, Inc. Photonic crystal defect cavity biosensor
AU2005327173A1 (en) 2004-06-28 2006-08-17 Sru Biosystems, Inc. Integration of direct binding sensors with mass spectrometry for functional and structural characterization of molecules
DE102004052510A1 (en) 2004-10-21 2006-04-27 Wilhelm Stahlecker Gmbh Air jet spinning machine
ATE475886T1 (en) 2005-04-12 2010-08-15 Sru Biosystems Inc PROTEOLIPID MEMBRANE AND LIPID MEMBRANE BIOSENSOR
US7197198B2 (en) 2005-06-23 2007-03-27 Sru Biosystems, Inc. Biosensor substrate structure for reducing the effects of optical interference
US7162125B1 (en) 2005-06-23 2007-01-09 Sru Biosystems, Inc. Optimized grating based biosensor and substrate combination
US7479404B2 (en) 2005-07-08 2009-01-20 The Board Of Trustees Of The University Of Illinois Photonic crystal biosensor structure and fabrication method
US7521769B2 (en) 2005-07-08 2009-04-21 Sru Biosystems, Inc. Photonic crystal biosensor structure and fabrication method
US7483127B1 (en) 2005-08-08 2009-01-27 Sru Biosystems, Inc. Method and apparatus for generating an image of biomolecular sensor target area
US7790406B2 (en) 2005-08-11 2010-09-07 Sru Biosystems, Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
CA2615217A1 (en) 2005-08-11 2007-02-15 Sru Biosystems, Inc. Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
EP2041554A2 (en) 2006-07-07 2009-04-01 The Board of Trustees of the University of Illinois Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio
JP2010508520A (en) 2006-10-31 2010-03-18 エス アール ユー バイオシステムズ，インコーポレイテッド Method for blocking non-specific protein binding on functionalized surfaces
AU2007319975B2 (en) 2006-11-09 2011-03-03 Sru Biosystems, Inc. Photonic crystal sensors with integrated fluid containment structure
US7628085B2 (en) 2006-11-17 2009-12-08 Sru Biosystems, Inc. Simultaneous aspirator and dispenser for multiwell plates and similar devices
US7497318B2 (en) 2007-03-07 2009-03-03 Chun-Wei Lin Conveying and stacking device for corrugated boards
US20080240543A1 (en) 2007-03-30 2008-10-02 Wolfgang Ernst Gustav Budach Calibration and normalization method for biosensors
US20080299673A1 (en) 2007-04-19 2008-12-04 Sru Biosystems, Inc. Method for Employing a Biosensor to Detect Small Molecules ("Fragments") that Bind Directly to Immobilized Protein Targets
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US8268637B2 (en) 2008-01-11 2012-09-18 The Board Of Trustees Of The University Of Illinois Label-free biosensors based upon distributed feedback laser
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
WO2009149285A1 (en) 2008-06-04 2009-12-10 Sru Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
US20100008826A1 (en) 2008-07-10 2010-01-14 Sru Biosystems, Inc. Biosensors featuring confinement of deposited material and intra-well self-referencing
JP2011527573A (en) 2008-07-11 2011-11-04 エス アール ユー バイオシステムズ，インコーポレイテッド Methods for identifying regulators of ion channels
US8094305B2 (en) 2009-02-02 2012-01-10 Sru Biosystems, Inc. Efficient optical arrangement for illumination and detection of label-free biosensors and method to reduce interference fringes in label-free imaging

Also Published As

Publication number Publication date
EP1337847A1 (en) 2003-08-27
US7118710B2 (en) 2006-10-10
WO2002059602A3 (en) 2003-01-30
JP2009025312A (en) 2009-02-05
US20020168295A1 (en) 2002-11-14
AU2002249786B2 (en) 2006-03-30
US20060030033A1 (en) 2006-02-09
US20050227374A1 (en) 2005-10-13
JP4202140B2 (en) 2008-12-24
CA2427689C (en) 2012-01-24
US7094595B2 (en) 2006-08-22
US7422891B2 (en) 2008-09-09
WO2002061429A8 (en) 2003-05-15
US7435385B2 (en) 2008-10-14
JP2008309799A (en) 2008-12-25
CA2427689A1 (en) 2002-08-08
US8101423B2 (en) 2012-01-24
JP2004529324A (en) 2004-09-24
US20090148955A1 (en) 2009-06-11
US20020127565A1 (en) 2002-09-12
EP2402739A1 (en) 2012-01-04
WO2002059602A2 (en) 2002-08-01
AU2002246885A1 (en) 2002-08-06
WO2002061429A2 (en) 2002-08-08
US20040132172A1 (en) 2004-07-08

Similar Documents

Publication Publication Date Title
WO2002059602A8 (en) A label-free high-throughput optical technique for detecting biomolecular interactions
WO2003064995A3 (en) A guided mode resonant filter biosensor using a linear grating surface structure
AU2884401A (en) Photothermic transducing spectroscopic analyzer
AU2001288293A1 (en) Scannable barcode display and methods for using the same
AU2002367180A1 (en) Concentration measuring method
AU2003207980A1 (en) Changing the temperature of a liquid sample and a receptacle useful therefor
AU2002212975A1 (en) Methods of altering the resonance of waveguide micro-resonators
AU2002231189A1 (en) Optical bio-discs and methods relating thereto
AU2002243369A1 (en) Polirized light sources and methods for making the same
AU2001271937A1 (en) Apparatus and method for evanescent light fluoroassays
AU2690701A (en) Spectroscopic probe
AU2003244812A1 (en) Fluid analysis using photonic crystal waveguide
AU2002248476A1 (en) Optimized defects in phonotic band-gap waveguides
AU2001270152A1 (en) Optical spectrum analyzer
AU2003224085A1 (en) Waveguide in porous substrates
AU2002216982A1 (en) Reverse symmetry waveguide for optical biosensing
AU2001235807A1 (en) Laser spectroscopic remote detection of surface contamination
AU2001241172A1 (en) Optical fiber and method for manufacturing the same
AU2002335663A1 (en) Methods and devices for detecting cell-cell interactions
AU2002212184A1 (en) Methods and reagents for protease inhibition
AU3386401A (en) Fluid sample receptacle
AU2001230484A1 (en) Method for the preparation of stable and reusable biosensing granules
AU2002325843A1 (en) Method for determining the interaction between keratinocytes and neurons
AU2002239733A1 (en) Methods for the identification of inhibitors of cysteine syhthase in plants
AU9227001A (en) Inp single crystal substrate

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WSNC Later publication of a supplementary international search report together with a suppl. search report established by non-competent authority
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
WWE Wipo information: entry into national phase

Ref document number: 10415037

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP