WO2002086416A3 - Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging - Google Patents

Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging Download PDF

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Publication number
WO2002086416A3
WO2002086416A3 PCT/US2002/014979 US0214979W WO02086416A3 WO 2002086416 A3 WO2002086416 A3 WO 2002086416A3 US 0214979 W US0214979 W US 0214979W WO 02086416 A3 WO02086416 A3 WO 02086416A3
Authority
WO
WIPO (PCT)
Prior art keywords
ensemble
correction
images
source
signals
Prior art date
Application number
PCT/US2002/014979
Other languages
French (fr)
Other versions
WO2002086416A2 (en
Inventor
James Riley
Keith Frost
Original Assignee
Amnis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amnis Corp filed Critical Amnis Corp
Priority to EP02764355A priority Critical patent/EP1389956B1/en
Priority to CA2445044A priority patent/CA2445044C/en
Priority to AU2002308693A priority patent/AU2002308693A1/en
Publication of WO2002086416A2 publication Critical patent/WO2002086416A2/en
Publication of WO2002086416A3 publication Critical patent/WO2002086416A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/32—Investigating bands of a spectrum in sequence by a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/36—Investigating two or more bands of a spectrum by separate detectors
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T5/00—Image enhancement or restoration
    • G06T5/50—Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/32—Determination of transform parameters for the alignment of images, i.e. image registration using correlation-based methods
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G01N15/1433—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/02—Preprocessing
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10032—Satellite or aerial image; Remote sensing
    • G06T2207/10036—Multispectral image; Hyperspectral image

Abstract

A multichannel imaging system generates an ensemble of images for each field of view of an object (401). Each image in the ensemble is intended to contain information from only one source among a plurality of sources for the object. However, due to crosstalk, at least a portion of the signal from a first source appears in a channel intended for a second source (404). Because the accuracy of the correction will be degraded if the images in an ensemble are spatially misaligned with respect to one another, the spatial offset between images is determined (408) and a correction is applied to substantially eliminate the offset. Then, a correction to the signals is determined to substantially reduce the contributions to the signal in a channel from the signals in other channels. The signal processing can be employed to process the output signals for each of a plurality of different disclosed imaging systems (409).
PCT/US2002/014979 2001-04-25 2002-04-24 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging WO2002086416A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02764355A EP1389956B1 (en) 2001-04-25 2002-04-24 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
CA2445044A CA2445044C (en) 2001-04-25 2002-04-24 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
AU2002308693A AU2002308693A1 (en) 2001-04-25 2002-04-24 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28671301P 2001-04-25 2001-04-25
US60/286,713 2001-04-25

Publications (2)

Publication Number Publication Date
WO2002086416A2 WO2002086416A2 (en) 2002-10-31
WO2002086416A3 true WO2002086416A3 (en) 2003-02-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/014979 WO2002086416A2 (en) 2001-04-25 2002-04-24 Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging

Country Status (5)

Country Link
US (4) US6763149B2 (en)
EP (1) EP1389956B1 (en)
AU (1) AU2002308693A1 (en)
CA (1) CA2445044C (en)
WO (1) WO2002086416A2 (en)

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