WO2003028756A2 - An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions - Google Patents
An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions Download PDFInfo
- Publication number
- WO2003028756A2 WO2003028756A2 PCT/CA2002/001476 CA0201476W WO03028756A2 WO 2003028756 A2 WO2003028756 A2 WO 2003028756A2 CA 0201476 W CA0201476 W CA 0201476W WO 03028756 A2 WO03028756 A2 WO 03028756A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- occlusion
- collagenase
- angioplasty
- proteolytic enzyme
- chronic
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24003—Microbial collagenase (3.4.24.3)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES02764443T ES2396964T3 (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate the crossing with guide wire of chronic arterial occlusions |
US10/491,424 US20050053548A1 (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
EP02764443A EP1438065B1 (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions |
DK02764443.4T DK1438065T3 (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate passage of a clue through chronic artery occlusions |
JP2003532086A JP2005503820A (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate passage of guidewire in complete arterial occlusion |
IL16113702A IL161137A0 (en) | 2001-10-01 | 2002-10-01 | Use of a formulation containing collagenase for degrading collagen in occluded arteries |
CA2462512A CA2462512C (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
SI200231019T SI1438065T1 (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions |
AU2002328729A AU2002328729C1 (en) | 2001-10-01 | 2002-10-01 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
IL161137A IL161137A (en) | 2001-10-01 | 2004-03-29 | Collagenase enzyme containing formulation useful for treatment of a fibrotic chronic total occlusion |
HK05108158A HK1076037A1 (en) | 2001-10-01 | 2005-09-16 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
US11/534,351 US7425326B2 (en) | 2001-10-01 | 2006-09-22 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
US12/211,574 US8021660B2 (en) | 2001-10-01 | 2008-09-16 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32553901P | 2001-10-01 | 2001-10-01 | |
US60/325,539 | 2001-10-01 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10491424 A-371-Of-International | 2002-10-01 | ||
US11/534,351 Continuation US7425326B2 (en) | 2001-10-01 | 2006-09-22 | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003028756A2 true WO2003028756A2 (en) | 2003-04-10 |
WO2003028756A3 WO2003028756A3 (en) | 2003-08-28 |
Family
ID=23268311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2002/001476 WO2003028756A2 (en) | 2001-10-01 | 2002-10-01 | An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions |
Country Status (13)
Country | Link |
---|---|
US (3) | US20050053548A1 (en) |
EP (1) | EP1438065B1 (en) |
JP (1) | JP2005503820A (en) |
CN (1) | CN1327893C (en) |
AU (1) | AU2002328729C1 (en) |
CA (1) | CA2462512C (en) |
DK (1) | DK1438065T3 (en) |
ES (1) | ES2396964T3 (en) |
HK (1) | HK1076037A1 (en) |
IL (2) | IL161137A0 (en) |
PT (1) | PT1438065E (en) |
SI (1) | SI1438065T1 (en) |
WO (1) | WO2003028756A2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005097177A1 (en) * | 2004-04-08 | 2005-10-20 | Strauss Bradley H | Use of collagenase to facilitate guide wire crossing in total arterial occlusions |
WO2006058434A1 (en) | 2004-12-02 | 2006-06-08 | Strauss Bradley H | Augmentation of intraluminal microvessel formation to facilitate guide wire crossing in chronic total occlusions |
EP1806052A1 (en) * | 2006-01-05 | 2007-07-11 | Fujifilm Corporation | Method for producing model animal of vascular wall lesion |
WO2008104620A1 (en) * | 2007-02-26 | 2008-09-04 | Proyecto De Biomedicina Cima, S.L. | Use of matrix metalloproteinase-10 (mmp-10) for thrombolytic treatments |
US8541370B2 (en) | 2007-02-26 | 2013-09-24 | Proyecto De Biomedicina Cima, S.L. | Use of matrix metalloproteinase-10 (MMP-10) for thrombolytic treatments |
CN103340663A (en) * | 2013-06-17 | 2013-10-09 | 李宝童 | Capsule type coronary oppressing device and method for manufacturing chronic myocardial ischemia animal model |
WO2020006444A1 (en) * | 2018-06-28 | 2020-01-02 | Marizyme Biotech | Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices |
CN115245143A (en) * | 2022-07-06 | 2022-10-28 | 上海市中西医结合医院 | Construction method of artery occlusive disease animal model |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003525048A (en) * | 2000-03-02 | 2003-08-26 | インサイト・ゲノミックス・インコーポレイテッド | Lipid metabolizing enzymes |
US6569129B1 (en) * | 2000-09-13 | 2003-05-27 | Mayo Foundation For Medical Education And Research | Biological revascularization |
PT1438065E (en) * | 2001-10-01 | 2013-01-24 | Matrizyme Pharma Corp | Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions |
US20070184083A1 (en) * | 2006-02-07 | 2007-08-09 | Medtronic Vascular, Inc. | Drug-Eluting Device for Treatment of Chronic Total Occlusions |
US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
US8016799B2 (en) * | 2008-04-22 | 2011-09-13 | Medtronic Vascular, Inc. | Catheter having a detachable tip |
WO2011130537A2 (en) * | 2010-04-14 | 2011-10-20 | Northwestern University | Pharmaceutical compositions and methods for digesting atherosclerotic plaques |
US20120259314A1 (en) * | 2011-04-11 | 2012-10-11 | Medtronic Vascular, Inc. | Apparatus and Methods for Recanalization of a Chronic Total Occlusion |
CN103157099B (en) * | 2011-12-19 | 2015-03-18 | 吴宗贵 | Mixed enzyme digestive juice for fast digestion of vascular adventitia and preparation method thereof |
US9636385B2 (en) | 2012-10-24 | 2017-05-02 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
WO2014134532A1 (en) * | 2013-02-28 | 2014-09-04 | Ventrix, Inc. | Methods and compositions for tissue therapy and analysis |
CN110248695B (en) * | 2016-12-15 | 2024-03-12 | 卢塞德血管有限公司 | Methods and devices for treating vascular-related diseases |
US20220265291A9 (en) * | 2018-06-28 | 2022-08-25 | Marizyme, Inc. | Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices |
Citations (3)
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US5811248A (en) | 1986-03-31 | 1998-09-22 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
US6020181A (en) | 1995-05-17 | 2000-02-01 | New York Blood, Inc. | Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase |
US6025477A (en) | 1986-03-31 | 2000-02-15 | Calenoff; Emanuel | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
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US4636195A (en) * | 1982-04-02 | 1987-01-13 | Harvey Wolinsky | Method and apparatus for removing arterial constriction |
US5955584A (en) * | 1986-03-31 | 1999-09-21 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
US5163421A (en) * | 1988-01-22 | 1992-11-17 | Angiosonics, Inc. | In vivo ultrasonic system with angioplasty and ultrasonic contrast imaging |
US5024829A (en) * | 1988-11-21 | 1991-06-18 | Centocor, Inc. | Method of imaging coronary thrombi |
US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
JPH05501855A (en) * | 1989-05-17 | 1993-04-08 | リサーチ、コーポレーション、テクノロジーズ、インコーポレーテッド | Methods and compositions for treating thrombosis in mammals |
US5422261A (en) * | 1993-04-16 | 1995-06-06 | Baxter International Inc. | Composition containing collagenase and chymopapain for hydrolyzing connective tissue to isolate cells |
US5613949A (en) * | 1994-04-01 | 1997-03-25 | Advanced Cardiovascular Systems, Inc. | Double balloon catheter assembly |
US5540637A (en) | 1995-01-25 | 1996-07-30 | Ccs, Llc | Stationary exercise apparatus having a preferred foot platform orientation |
US6306166B1 (en) * | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
EP0920882A3 (en) | 1997-12-04 | 2000-01-05 | Schneider Inc. | Balloon dilatation-drug delivery catheter and stent deployment-drug delivery catheter in rapid exchange configuration |
EP1060747A3 (en) * | 1999-06-16 | 2001-12-05 | New York Blood Center, Inc. | Fibrin(ogen) degradation and clot lysis by fibrinolytic metalloproteinase |
US6569129B1 (en) * | 2000-09-13 | 2003-05-27 | Mayo Foundation For Medical Education And Research | Biological revascularization |
US6623452B2 (en) * | 2000-12-19 | 2003-09-23 | Scimed Life Systems, Inc. | Drug delivery catheter having a highly compliant balloon with infusion holes |
US6780849B2 (en) * | 2000-12-21 | 2004-08-24 | Scimed Life Systems, Inc. | Lipid-based nitric oxide donors |
US6808518B2 (en) * | 2001-09-28 | 2004-10-26 | Ethicon, Inc. | Methods and devices for treating diseased blood vessels |
PT1438065E (en) * | 2001-10-01 | 2013-01-24 | Matrizyme Pharma Corp | Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions |
-
2002
- 2002-10-01 PT PT2764443T patent/PT1438065E/en unknown
- 2002-10-01 CN CNB028241029A patent/CN1327893C/en not_active Expired - Fee Related
- 2002-10-01 JP JP2003532086A patent/JP2005503820A/en active Pending
- 2002-10-01 WO PCT/CA2002/001476 patent/WO2003028756A2/en active Application Filing
- 2002-10-01 CA CA2462512A patent/CA2462512C/en not_active Expired - Lifetime
- 2002-10-01 US US10/491,424 patent/US20050053548A1/en not_active Abandoned
- 2002-10-01 EP EP02764443A patent/EP1438065B1/en not_active Expired - Lifetime
- 2002-10-01 DK DK02764443.4T patent/DK1438065T3/en active
- 2002-10-01 ES ES02764443T patent/ES2396964T3/en not_active Expired - Lifetime
- 2002-10-01 SI SI200231019T patent/SI1438065T1/en unknown
- 2002-10-01 AU AU2002328729A patent/AU2002328729C1/en not_active Ceased
- 2002-10-01 IL IL16113702A patent/IL161137A0/en unknown
-
2004
- 2004-03-29 IL IL161137A patent/IL161137A/en active IP Right Grant
-
2005
- 2005-09-16 HK HK05108158A patent/HK1076037A1/en not_active IP Right Cessation
-
2006
- 2006-09-22 US US11/534,351 patent/US7425326B2/en not_active Expired - Lifetime
-
2008
- 2008-09-16 US US12/211,574 patent/US8021660B2/en not_active Expired - Fee Related
Patent Citations (3)
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US5811248A (en) | 1986-03-31 | 1998-09-22 | Charter Ventures | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
US6025477A (en) | 1986-03-31 | 2000-02-15 | Calenoff; Emanuel | Atherosclerotic plaque specific antigens, antibodies thereto, and uses thereof |
US6020181A (en) | 1995-05-17 | 2000-02-01 | New York Blood, Inc. | Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase |
Non-Patent Citations (56)
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