WO2003028756A3 - An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions - Google Patents

An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions Download PDF

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Publication number
WO2003028756A3
WO2003028756A3 PCT/CA2002/001476 CA0201476W WO03028756A3 WO 2003028756 A3 WO2003028756 A3 WO 2003028756A3 CA 0201476 W CA0201476 W CA 0201476W WO 03028756 A3 WO03028756 A3 WO 03028756A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagenase
chronic arterial
occlusion
guide wire
animal
Prior art date
Application number
PCT/CA2002/001476
Other languages
French (fr)
Other versions
WO2003028756A2 (en
Inventor
Bradley H Strauss
Original Assignee
Bradley H Strauss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SI200231019T priority Critical patent/SI1438065T1/en
Priority to CA2462512A priority patent/CA2462512C/en
Priority to ES02764443T priority patent/ES2396964T3/en
Priority to DK02764443.4T priority patent/DK1438065T3/en
Application filed by Bradley H Strauss filed Critical Bradley H Strauss
Priority to AU2002328729A priority patent/AU2002328729C1/en
Priority to US10/491,424 priority patent/US20050053548A1/en
Priority to EP02764443A priority patent/EP1438065B1/en
Priority to IL16113702A priority patent/IL161137A0/en
Priority to JP2003532086A priority patent/JP2005503820A/en
Publication of WO2003028756A2 publication Critical patent/WO2003028756A2/en
Publication of WO2003028756A3 publication Critical patent/WO2003028756A3/en
Priority to IL161137A priority patent/IL161137A/en
Priority to HK05108158A priority patent/HK1076037A1/en
Priority to US11/534,351 priority patent/US7425326B2/en
Priority to US12/211,574 priority patent/US8021660B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24003—Microbial collagenase (3.4.24.3)

Abstract

The field of the invention relates to percutaneous interventions of occluded arteries using local infusion of collagenase or a combination of enzymes that include collagenase. A method of is provided for treating chronically occluded animal tubes and cavities by administering a therapeutic effective amount of a proteolytic enzyme-containing formulation adjacent to an occluding atherosclerotic plaque, waiting for a pre-angioplasty waiting period, followed by crossing the plaque with an angioplasty guide wire. An in-vivo animal model of developing a chronic arterial occlusions is provided having the steps of isolating a segment of an animal artery, stopping blood flow with occlusive ligatures in the isolated arterial segment of the animal artery, injecting topical thrombin into the isolated arterial segment to form an acute thrombotic occlusion, and waiting while the acute thrombotic occlusion is converted into a chronic fibrotic occlusion.
PCT/CA2002/001476 2001-10-01 2002-10-01 An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions WO2003028756A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
US10/491,424 US20050053548A1 (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate guide wire crossing in total arterial occlusions
ES02764443T ES2396964T3 (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate the crossing with guide wire of chronic arterial occlusions
DK02764443.4T DK1438065T3 (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate passage of a clue through chronic artery occlusions
IL16113702A IL161137A0 (en) 2001-10-01 2002-10-01 Use of a formulation containing collagenase for degrading collagen in occluded arteries
AU2002328729A AU2002328729C1 (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate guide wire crossing in total arterial occlusions
CA2462512A CA2462512C (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate guide wire crossing in total arterial occlusions
EP02764443A EP1438065B1 (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions
SI200231019T SI1438065T1 (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions
JP2003532086A JP2005503820A (en) 2001-10-01 2002-10-01 Use of collagenase to facilitate passage of guidewire in complete arterial occlusion
IL161137A IL161137A (en) 2001-10-01 2004-03-29 Collagenase enzyme containing formulation useful for treatment of a fibrotic chronic total occlusion
HK05108158A HK1076037A1 (en) 2001-10-01 2005-09-16 Use of collagenase to facilitate guide wire crossing in total arterial occlusions
US11/534,351 US7425326B2 (en) 2001-10-01 2006-09-22 Use of collagenase to facilitate guide wire crossing in total arterial occlusions
US12/211,574 US8021660B2 (en) 2001-10-01 2008-09-16 Use of collagenase to facilitate guide wire crossing in total arterial occlusions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32553901P 2001-10-01 2001-10-01
US60/325,539 2001-10-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10491424 A-371-Of-International 2002-10-01
US11/534,351 Continuation US7425326B2 (en) 2001-10-01 2006-09-22 Use of collagenase to facilitate guide wire crossing in total arterial occlusions

Publications (2)

Publication Number Publication Date
WO2003028756A2 WO2003028756A2 (en) 2003-04-10
WO2003028756A3 true WO2003028756A3 (en) 2003-08-28

Family

ID=23268311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001476 WO2003028756A2 (en) 2001-10-01 2002-10-01 An in vivo animal model of chronic arterial occlusion and use of collagenase to facilitate guide wire crossing in chronic arterial occlusions

Country Status (13)

Country Link
US (3) US20050053548A1 (en)
EP (1) EP1438065B1 (en)
JP (1) JP2005503820A (en)
CN (1) CN1327893C (en)
AU (1) AU2002328729C1 (en)
CA (1) CA2462512C (en)
DK (1) DK1438065T3 (en)
ES (1) ES2396964T3 (en)
HK (1) HK1076037A1 (en)
IL (2) IL161137A0 (en)
PT (1) PT1438065E (en)
SI (1) SI1438065T1 (en)
WO (1) WO2003028756A2 (en)

Cited By (1)

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CN103340663A (en) * 2013-06-17 2013-10-09 李宝童 Capsule type coronary oppressing device and method for manufacturing chronic myocardial ischemia animal model

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JP2003525048A (en) * 2000-03-02 2003-08-26 インサイト・ゲノミックス・インコーポレイテッド Lipid metabolizing enzymes
US6569129B1 (en) * 2000-09-13 2003-05-27 Mayo Foundation For Medical Education And Research Biological revascularization
EP1438065B1 (en) * 2001-10-01 2012-11-21 Matrizyme Pharma Corporation Use of collagenase to facilitate guide wire crossing in chronic arterial occlusions
WO2005097177A1 (en) * 2004-04-08 2005-10-20 Strauss Bradley H Use of collagenase to facilitate guide wire crossing in total arterial occlusions
ES2542987T3 (en) * 2004-12-02 2015-08-13 Bradley H. Strauss Increase in the formation of intraluminal microvessels to facilitate the crossing of probes in chronic total occlusions
JP2007181413A (en) * 2006-01-05 2007-07-19 Fujifilm Corp Method for creating vascular wall-damaged model animal
US20070184083A1 (en) * 2006-02-07 2007-08-09 Medtronic Vascular, Inc. Drug-Eluting Device for Treatment of Chronic Total Occlusions
ES2335167B1 (en) * 2007-02-26 2011-01-24 Proyecto De Biomedicina Cima, S.L. USE OF METALOPROTEINASE MATRIX-10 (MMP10) FOR THROMBOLITIC TREATMENTS.
US8541370B2 (en) 2007-02-26 2013-09-24 Proyecto De Biomedicina Cima, S.L. Use of matrix metalloproteinase-10 (MMP-10) for thrombolytic treatments
US10071143B1 (en) 2007-05-03 2018-09-11 The Research Foundation For The State University Of New York Methods for non-surgical treatment of carpal tunnel syndrome
US8016799B2 (en) * 2008-04-22 2011-09-13 Medtronic Vascular, Inc. Catheter having a detachable tip
WO2011130537A2 (en) * 2010-04-14 2011-10-20 Northwestern University Pharmaceutical compositions and methods for digesting atherosclerotic plaques
US20120259314A1 (en) * 2011-04-11 2012-10-11 Medtronic Vascular, Inc. Apparatus and Methods for Recanalization of a Chronic Total Occlusion
CN103157099B (en) * 2011-12-19 2015-03-18 吴宗贵 Mixed enzyme digestive juice for fast digestion of vascular adventitia and preparation method thereof
US9636385B2 (en) 2012-10-24 2017-05-02 The Research Foundation For The State University Of New York Use of collagenase to treat glaucoma
WO2014134532A1 (en) * 2013-02-28 2014-09-04 Ventrix, Inc. Methods and compositions for tissue therapy and analysis
EP3554626A4 (en) * 2016-12-15 2020-06-03 Luseed Vascular Ltd. Methods and devices for treating vascular related disorders
US20220265291A9 (en) * 2018-06-28 2022-08-25 Marizyme, Inc. Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices
CA3110779A1 (en) * 2018-06-28 2020-01-02 Michael K. HANDLEY Pharmaceutical compositions and methods for the treatment of thrombosis and delivery by medical devices
CN115245143A (en) * 2022-07-06 2022-10-28 上海市中西医结合医院 Construction method of artery occlusive disease animal model

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Also Published As

Publication number Publication date
HK1076037A1 (en) 2006-01-06
US20070014783A1 (en) 2007-01-18
CA2462512A1 (en) 2003-04-10
AU2002328729A2 (en) 2003-04-14
CN1327893C (en) 2007-07-25
US20050053548A1 (en) 2005-03-10
DK1438065T3 (en) 2013-02-11
AU2002328729C1 (en) 2009-11-26
PT1438065E (en) 2013-01-24
IL161137A (en) 2014-08-31
WO2003028756A2 (en) 2003-04-10
EP1438065A2 (en) 2004-07-21
AU2002328729B2 (en) 2009-07-16
EP1438065B1 (en) 2012-11-21
CN1599621A (en) 2005-03-23
JP2005503820A (en) 2005-02-10
US7425326B2 (en) 2008-09-16
ES2396964T3 (en) 2013-03-01
US8021660B2 (en) 2011-09-20
IL161137A0 (en) 2004-08-31
CA2462512C (en) 2013-11-05
SI1438065T1 (en) 2013-03-29
US20090074744A1 (en) 2009-03-19

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