WO2003049669A3 - Methods, devices, and preparations for intervertebral disc treatment - Google Patents

Methods, devices, and preparations for intervertebral disc treatment Download PDF

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Publication number
WO2003049669A3
WO2003049669A3 PCT/IL2002/000997 IL0200997W WO03049669A3 WO 2003049669 A3 WO2003049669 A3 WO 2003049669A3 IL 0200997 W IL0200997 W IL 0200997W WO 03049669 A3 WO03049669 A3 WO 03049669A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparations
methods
devices
intervertebral disc
therapeutic method
Prior art date
Application number
PCT/IL2002/000997
Other languages
French (fr)
Other versions
WO2003049669A2 (en
Inventor
Shahar Pitaru
Matitiau Noff
Original Assignee
Colbar R & D Ltd
Shahar Pitaru
Matitiau Noff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colbar R & D Ltd, Shahar Pitaru, Matitiau Noff filed Critical Colbar R & D Ltd
Priority to AU2002358957A priority Critical patent/AU2002358957A1/en
Priority to CA002482309A priority patent/CA2482309A1/en
Priority to BRPI0215131A priority patent/BRPI0215131A8/en
Priority to DE60232819T priority patent/DE60232819D1/en
Priority to JP2003550720A priority patent/JP2005511207A/en
Priority to EP02793301A priority patent/EP1465558B1/en
Priority to MXPA04005707A priority patent/MXPA04005707A/en
Priority to IL16241902A priority patent/IL162419A0/en
Priority to AT02793301T priority patent/ATE434996T1/en
Publication of WO2003049669A2 publication Critical patent/WO2003049669A2/en
Publication of WO2003049669A3 publication Critical patent/WO2003049669A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/044—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Abstract

A therapeutic method for treating mammalian intervertebral discs (30). A preparation of cross-linked collagen (39) is injected under pressure into the intradiscal space. The intervertebral distance in injected discs is immediately increased by the treatment. At least some mechanical properties of the treated vertebral column are preserved or partially restored. The method may be used to relieve back pain in patients, to increase patient height and to stabilized the spinal column. The therapeutic method may result in at least a partial regeneration of the nucleus pulposus (34), and/or development of cartilaginous or fibrocartilaginous tissues or dense fibrous tissues.
PCT/IL2002/000997 2001-12-10 2002-12-10 Methods, devices, and preparations for intervertebral disc treatment WO2003049669A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2002358957A AU2002358957A1 (en) 2001-12-10 2002-12-10 Methods, devices, and preparations for intervertebral disc treatment
CA002482309A CA2482309A1 (en) 2001-12-10 2002-12-10 Methods, devices, and preparations for intervertebral disc treatment
BRPI0215131A BRPI0215131A8 (en) 2001-12-10 2002-12-10 METHODS, APPLIANCES AND PREPARATIONS FOR THE TREATMENT OF INTERVERTEBRAL DISCS
DE60232819T DE60232819D1 (en) 2001-12-10 2002-12-10 USE OF NETWORKED COLLAGEN FOR THE TREATMENT OF BELTS
JP2003550720A JP2005511207A (en) 2001-12-10 2002-12-10 Intervertebral disc treatment methods, devices, and preparations
EP02793301A EP1465558B1 (en) 2001-12-10 2002-12-10 Use of cross-linked collagen for intervertebral disc treatment
MXPA04005707A MXPA04005707A (en) 2001-12-10 2002-12-10 Methods, devices, and preparations for intervertebral disc treatment.
IL16241902A IL162419A0 (en) 2001-12-10 2002-12-10 Methods, devices, and preparations for intervertebral disc treatment
AT02793301T ATE434996T1 (en) 2001-12-10 2002-12-10 USE OF CROSS-LINKED COLLAGEN TO TREAT INTERVERBAL DISCS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33714501P 2001-12-10 2001-12-10
US60/337,145 2001-12-10

Publications (2)

Publication Number Publication Date
WO2003049669A2 WO2003049669A2 (en) 2003-06-19
WO2003049669A3 true WO2003049669A3 (en) 2004-03-11

Family

ID=23319301

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000997 WO2003049669A2 (en) 2001-12-10 2002-12-10 Methods, devices, and preparations for intervertebral disc treatment

Country Status (11)

Country Link
US (1) US20040010251A1 (en)
EP (1) EP1465558B1 (en)
JP (1) JP2005511207A (en)
AT (1) ATE434996T1 (en)
AU (1) AU2002358957A1 (en)
BR (1) BRPI0215131A8 (en)
CA (1) CA2482309A1 (en)
DE (1) DE60232819D1 (en)
IL (1) IL162419A0 (en)
MX (1) MXPA04005707A (en)
WO (1) WO2003049669A2 (en)

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Also Published As

Publication number Publication date
ATE434996T1 (en) 2009-07-15
JP2005511207A (en) 2005-04-28
IL162419A0 (en) 2005-11-20
AU2002358957A1 (en) 2003-06-23
CA2482309A1 (en) 2003-06-19
EP1465558B1 (en) 2009-07-01
US20040010251A1 (en) 2004-01-15
DE60232819D1 (en) 2009-08-13
BRPI0215131A8 (en) 2017-09-12
EP1465558A2 (en) 2004-10-13
WO2003049669A2 (en) 2003-06-19
MXPA04005707A (en) 2005-06-20
EP1465558A4 (en) 2005-03-16
BR0215131A (en) 2005-04-26

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