WO2003067267A3 - Squid detected nmr and mri at ultralow fields - Google Patents

Squid detected nmr and mri at ultralow fields Download PDF

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Publication number
WO2003067267A3
WO2003067267A3 PCT/US2003/003712 US0303712W WO03067267A3 WO 2003067267 A3 WO2003067267 A3 WO 2003067267A3 US 0303712 W US0303712 W US 0303712W WO 03067267 A3 WO03067267 A3 WO 03067267A3
Authority
WO
WIPO (PCT)
Prior art keywords
fields
squid
mri
nmr
detected nmr
Prior art date
Application number
PCT/US2003/003712
Other languages
French (fr)
Other versions
WO2003067267A2 (en
Inventor
John Clarke
Robert Mcdermott
Alexander Pines
Andreas Heinz Trabesinger
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Priority to EA200401028A priority Critical patent/EA006832B1/en
Priority to AU2003210906A priority patent/AU2003210906B2/en
Priority to APAP/P/2004/003127A priority patent/AP2004003127A0/en
Priority to CA2478466A priority patent/CA2478466C/en
Priority to IL16366903A priority patent/IL163669A0/en
Priority to EP03737699A priority patent/EP1474707B1/en
Priority to MXPA04008593A priority patent/MXPA04008593A/en
Priority to NZ534963A priority patent/NZ534963A/en
Publication of WO2003067267A2 publication Critical patent/WO2003067267A2/en
Publication of WO2003067267A3 publication Critical patent/WO2003067267A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/323—Detection of MR without the use of RF or microwaves, e.g. force-detected MR, thermally detected MR, MR detection via electrical conductivity, optically detected MR
    • G01R33/326—Detection of MR without the use of RF or microwaves, e.g. force-detected MR, thermally detected MR, MR detection via electrical conductivity, optically detected MR involving a SQUID
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/02—Measuring direction or magnitude of magnetic fields or magnetic flux
    • G01R33/035—Measuring direction or magnitude of magnetic fields or magnetic flux using superconductive devices
    • G01R33/0354—SQUIDS
    • G01R33/0356—SQUIDS with flux feedback
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/445—MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging

Abstract

Nuclear magnetic resonance signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device 'SQUID' (31) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio 'SNR' and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields.
PCT/US2003/003712 2002-02-06 2003-02-06 Squid detected nmr and mri at ultralow fields WO2003067267A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EA200401028A EA006832B1 (en) 2002-02-06 2003-02-06 Squid detected nmr and mri at ultraflow fields
AU2003210906A AU2003210906B2 (en) 2002-02-06 2003-02-06 SQUID detected NMR and MRI at ultralow fields
APAP/P/2004/003127A AP2004003127A0 (en) 2002-02-06 2003-02-06 Squid detected NMR and MR1 at ultralow fields
CA2478466A CA2478466C (en) 2002-02-06 2003-02-06 Squid detected nmr and mri at ultralow fields
IL16366903A IL163669A0 (en) 2002-02-06 2003-02-06 Squid detected nmr and mri at ultralow fields
EP03737699A EP1474707B1 (en) 2002-02-06 2003-02-06 Squid detected nmr and mri at ultralow fields
MXPA04008593A MXPA04008593A (en) 2002-02-06 2003-02-06 Squid detected nmr and mri at ultralow fields.
NZ534963A NZ534963A (en) 2002-02-06 2003-02-06 SQUID Detected NMR and MRI at ultralow fields

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35557702P 2002-02-06 2002-02-06
US60/355,577 2002-02-06

Publications (2)

Publication Number Publication Date
WO2003067267A2 WO2003067267A2 (en) 2003-08-14
WO2003067267A3 true WO2003067267A3 (en) 2003-11-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003712 WO2003067267A2 (en) 2002-02-06 2003-02-06 Squid detected nmr and mri at ultralow fields

Country Status (12)

Country Link
US (5) US6885192B2 (en)
EP (1) EP1474707B1 (en)
CN (1) CN1287160C (en)
AP (1) AP2004003127A0 (en)
AU (1) AU2003210906B2 (en)
CA (1) CA2478466C (en)
EA (1) EA006832B1 (en)
IL (1) IL163669A0 (en)
MX (1) MXPA04008593A (en)
NZ (1) NZ534963A (en)
WO (1) WO2003067267A2 (en)
ZA (1) ZA200406984B (en)

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Publication number Publication date
EP1474707A4 (en) 2005-05-25
US7218104B2 (en) 2007-05-15
CA2478466C (en) 2013-09-17
US20040027125A1 (en) 2004-02-12
CN1287160C (en) 2006-11-29
US7053610B2 (en) 2006-05-30
CN1643403A (en) 2005-07-20
EP1474707B1 (en) 2012-07-18
EA006832B1 (en) 2006-04-28
WO2003067267A2 (en) 2003-08-14
EA200401028A1 (en) 2005-04-28
IL163669A0 (en) 2005-12-18
AP2004003127A0 (en) 2004-09-30
AU2003210906B2 (en) 2010-06-03
ZA200406984B (en) 2005-09-20
MXPA04008593A (en) 2004-12-06
US6885192B2 (en) 2005-04-26
US7466132B2 (en) 2008-12-16
AU2003210906A1 (en) 2003-09-02
EP1474707A2 (en) 2004-11-10
NZ534963A (en) 2006-02-24
US20070018643A1 (en) 2007-01-25
US20080074113A1 (en) 2008-03-27
US20060176054A1 (en) 2006-08-10
CA2478466A1 (en) 2003-08-14
US20050134262A1 (en) 2005-06-23
US7116102B2 (en) 2006-10-03

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