WO2003068149A3 - Preparations of nucleus pulposus cells and methods for their generation, identification, and use - Google Patents

Preparations of nucleus pulposus cells and methods for their generation, identification, and use Download PDF

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Publication number
WO2003068149A3
WO2003068149A3 PCT/US2003/003608 US0303608W WO03068149A3 WO 2003068149 A3 WO2003068149 A3 WO 2003068149A3 US 0303608 W US0303608 W US 0303608W WO 03068149 A3 WO03068149 A3 WO 03068149A3
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WO
WIPO (PCT)
Prior art keywords
nucleus pulposus
methods
pulposus cells
preparations
identification
Prior art date
Application number
PCT/US2003/003608
Other languages
French (fr)
Other versions
WO2003068149A2 (en
Inventor
Irving Shapiro
Ramesh Rajpurohit
Paul Ducheyne
Original Assignee
Trustees Of The University Pen
Irving Shapiro
Ramesh Rajpurohit
Paul Ducheyne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of The University Pen, Irving Shapiro, Ramesh Rajpurohit, Paul Ducheyne filed Critical Trustees Of The University Pen
Priority to AU2003210884A priority Critical patent/AU2003210884A1/en
Publication of WO2003068149A2 publication Critical patent/WO2003068149A2/en
Publication of WO2003068149A3 publication Critical patent/WO2003068149A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/12—Glass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Abstract

The present invention is directed to novel compositions and methods for the treatment of degenerative intervertebral disc disease. In some embodiments, the invention relates to a preparation of nucleus pulposus cells comprising purified nucleus pulposus cells. In some embodiments, the invention relates to methods of treating degenerative intervertebral disc disease in an individual comprising implanting nucleus pulposus cells into the nucleus pulposus space of a degenerated disc of the individual. Other embodiments of the invention relate to methods of generating nucleus pulposus cells.
PCT/US2003/003608 2002-02-09 2003-02-07 Preparations of nucleus pulposus cells and methods for their generation, identification, and use WO2003068149A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003210884A AU2003210884A1 (en) 2002-02-09 2003-02-07 Preparations of nucleus pulposus cells and methods for their generation, identification, and use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35495602P 2002-02-09 2002-02-09
US60/354,956 2002-02-09
US10/359,419 US20030220692A1 (en) 2002-02-09 2003-02-06 Preparations of nucleus pulposus cells and methods for their generation, identification, and use
US10/359,419 2003-02-06

Publications (2)

Publication Number Publication Date
WO2003068149A2 WO2003068149A2 (en) 2003-08-21
WO2003068149A3 true WO2003068149A3 (en) 2004-01-08

Family

ID=27737479

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003608 WO2003068149A2 (en) 2002-02-09 2003-02-07 Preparations of nucleus pulposus cells and methods for their generation, identification, and use

Country Status (3)

Country Link
US (1) US20030220692A1 (en)
AU (1) AU2003210884A1 (en)
WO (1) WO2003068149A2 (en)

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US7771414B2 (en) 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642060B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs

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US7429378B2 (en) * 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US7553827B2 (en) * 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US20070093907A1 (en) * 2005-10-26 2007-04-26 Goupil Dennis W Hydrogel spinal disc implants with swellable articles
US7879027B2 (en) 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US20120100607A1 (en) * 2007-07-12 2012-04-26 Christopher Duntsch Compositions of adult disc stem cells and methods for the treatment of degenerative disc disease
US10633632B2 (en) 2007-07-12 2020-04-28 Discgenics, Inc. Human disc tissue
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US20090162351A1 (en) * 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
US8986696B2 (en) 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
US8603819B2 (en) 2008-05-23 2013-12-10 The Regents Of The University Of California Compositions and methods for generating musculoskeletal tissue
WO2010088775A1 (en) * 2009-02-06 2010-08-12 University Health Network Methods and uses of hypoxic compartment cells
CA2767715C (en) * 2009-07-10 2017-09-26 Bio2 Technologies, Inc. Synthetic bone prosthesis comprising bioactive glass fibers bonded to each other via an exothermic reaction of volatile components
US11891626B2 (en) * 2013-03-15 2024-02-06 Discgenics, Inc. Isolated discogenic cells, methods of using, and methods of preparing same from mammalian tissue
US10449055B2 (en) 2015-04-23 2019-10-22 Disc Fix L.L.C. Systems and methods for treatment of intervertebral disc derangements
JP6712740B1 (en) * 2019-03-25 2020-06-24 学校法人東海大学 Method for culturing cell population containing Tie2-positive stem/progenitor cells and use thereof
JP6905234B2 (en) * 2019-09-09 2021-07-21 学校法人東海大学 Method for culturing a cell population containing Tie2-positive stem / progenitor cells and its utilization
JP6779492B2 (en) * 2019-09-09 2020-11-04 学校法人東海大学 Method for culturing a cell population containing Tie2-positive stem / progenitor cells and its utilization
JP7421182B2 (en) 2020-04-28 2024-01-24 学校法人東海大学 Method for culturing a cell population containing Tie2-positive stem/progenitor cells and its use

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
US7771414B2 (en) 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642060B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs

Also Published As

Publication number Publication date
AU2003210884A1 (en) 2003-09-04
US20030220692A1 (en) 2003-11-27
AU2003210884A8 (en) 2003-09-04
WO2003068149A2 (en) 2003-08-21

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