WO2003072186A3 - Neurostimulation for affecting sleep disorders - Google Patents

Neurostimulation for affecting sleep disorders Download PDF

Info

Publication number
WO2003072186A3
WO2003072186A3 PCT/US2003/002860 US0302860W WO03072186A3 WO 2003072186 A3 WO2003072186 A3 WO 2003072186A3 US 0302860 W US0302860 W US 0302860W WO 03072186 A3 WO03072186 A3 WO 03072186A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleus
affecting
neurostimulation
sleep disorders
sleep
Prior art date
Application number
PCT/US2003/002860
Other languages
French (fr)
Other versions
WO2003072186A2 (en
Inventor
Ali Rezai
Jorge Alvaro Gonzalez-Martinez
Ashwini Sharan
Original Assignee
Cleveland Clinic Foundation
Ali Rezai
Jorge Alvaro Gonzalez-Martinez
Ashwini Sharan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cleveland Clinic Foundation, Ali Rezai, Jorge Alvaro Gonzalez-Martinez, Ashwini Sharan filed Critical Cleveland Clinic Foundation
Priority to US10/502,820 priority Critical patent/US8612005B2/en
Priority to AU2003241269A priority patent/AU2003241269A1/en
Publication of WO2003072186A2 publication Critical patent/WO2003072186A2/en
Publication of WO2003072186A3 publication Critical patent/WO2003072186A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation

Abstract

A method of affecting a sleep disorder in a subject having the sleep disorder and a method of affecting a normal awakeness-sleep cycle in a subject having an abnormal awakeness-sleep cycle, said methods comprising: a) identifying at least one nucleus in a brain of the subject, said nucleus being a nucleus of the sleep circuitry of the brain; and b) stimulating the at least one identified nucleus so as to modulate the nucleus, thereby affecting the sleep disorder.
PCT/US2003/002860 2002-02-01 2003-01-31 Neurostimulation for affecting sleep disorders WO2003072186A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/502,820 US8612005B2 (en) 2002-02-01 2003-01-31 Neurostimulation for affecting sleep disorders
AU2003241269A AU2003241269A1 (en) 2002-02-01 2003-01-31 Neurostimulation for affecting sleep disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35369702P 2002-02-01 2002-02-01
US60/353,697 2002-02-01

Publications (2)

Publication Number Publication Date
WO2003072186A2 WO2003072186A2 (en) 2003-09-04
WO2003072186A3 true WO2003072186A3 (en) 2004-03-25

Family

ID=27734302

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/002860 WO2003072186A2 (en) 2002-02-01 2003-01-31 Neurostimulation for affecting sleep disorders

Country Status (3)

Country Link
US (1) US8612005B2 (en)
AU (1) AU2003241269A1 (en)
WO (1) WO2003072186A2 (en)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7073501B2 (en) * 1999-02-04 2006-07-11 Univerity Technologies International Inc. Ventilatory stabilization technology
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
US8396565B2 (en) 2003-09-15 2013-03-12 Medtronic, Inc. Automatic therapy adjustments
US7792583B2 (en) 2004-03-16 2010-09-07 Medtronic, Inc. Collecting posture information to evaluate therapy
US7491181B2 (en) * 2004-03-16 2009-02-17 Medtronic, Inc. Collecting activity and sleep quality information via a medical device
US7330760B2 (en) * 2004-03-16 2008-02-12 Medtronic, Inc. Collecting posture information to evaluate therapy
US20070276439A1 (en) * 2004-03-16 2007-11-29 Medtronic, Inc. Collecting sleep quality information via a medical device
US7366572B2 (en) * 2004-03-16 2008-04-29 Medtronic, Inc. Controlling therapy based on sleep quality
US7542803B2 (en) * 2004-03-16 2009-06-02 Medtronic, Inc. Sensitivity analysis for selecting therapy parameter sets
US8308661B2 (en) * 2004-03-16 2012-11-13 Medtronic, Inc. Collecting activity and sleep quality information via a medical device
US8055348B2 (en) * 2004-03-16 2011-11-08 Medtronic, Inc. Detecting sleep to evaluate therapy
US7717848B2 (en) 2004-03-16 2010-05-18 Medtronic, Inc. Collecting sleep quality information via a medical device
US7395113B2 (en) 2004-03-16 2008-07-01 Medtronic, Inc. Collecting activity information to evaluate therapy
US20050209512A1 (en) * 2004-03-16 2005-09-22 Heruth Kenneth T Detecting sleep
US8725244B2 (en) 2004-03-16 2014-05-13 Medtronic, Inc. Determination of sleep quality for neurological disorders
US7805196B2 (en) 2004-03-16 2010-09-28 Medtronic, Inc. Collecting activity information to evaluate therapy
US7881798B2 (en) 2004-03-16 2011-02-01 Medtronic Inc. Controlling therapy based on sleep quality
WO2005102449A1 (en) * 2004-04-14 2005-11-03 Medtronic, Inc. Collecting posture and activity information to evaluate therapy
US8135473B2 (en) 2004-04-14 2012-03-13 Medtronic, Inc. Collecting posture and activity information to evaluate therapy
US7346382B2 (en) 2004-07-07 2008-03-18 The Cleveland Clinic Foundation Brain stimulation models, systems, devices, and methods
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US8021299B2 (en) * 2005-06-01 2011-09-20 Medtronic, Inc. Correlating a non-polysomnographic physiological parameter set with sleep states
US20070027484A1 (en) * 2005-07-28 2007-02-01 Cyberonics, Inc. Autonomic nerve stimulation to treat a pancreatic disorder
US8660647B2 (en) 2005-07-28 2014-02-25 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US7856273B2 (en) * 2005-07-28 2010-12-21 Cyberonics, Inc. Autonomic nerve stimulation to treat a gastrointestinal disorder
US7706874B2 (en) 2005-07-28 2010-04-27 Cyberonics, Inc. Stimulating cranial nerve to treat disorders associated with the thyroid gland
US9037247B2 (en) 2005-11-10 2015-05-19 ElectroCore, LLC Non-invasive treatment of bronchial constriction
US7747324B2 (en) 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US8812112B2 (en) 2005-11-10 2014-08-19 ElectroCore, LLC Electrical treatment of bronchial constriction
US8041428B2 (en) 2006-02-10 2011-10-18 Electrocore Llc Electrical stimulation treatment of hypotension
US7725188B2 (en) 2006-02-10 2010-05-25 Electrocore Llc Electrical stimulation treatment of hypotension
US7957809B2 (en) 2005-12-02 2011-06-07 Medtronic, Inc. Closed-loop therapy adjustment
US8016776B2 (en) * 2005-12-02 2011-09-13 Medtronic, Inc. Wearable ambulatory data recorder
US20080199538A1 (en) * 2006-01-10 2008-08-21 Yronne Filopelrick Compound to enhance lucid erotic dreams
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
CN101400402A (en) 2006-02-10 2009-04-01 电子核心公司 Electrical stimulation treatment of hypotension
WO2007112092A2 (en) 2006-03-24 2007-10-04 Medtronic, Inc. Collecting gait information for evaluation and control of therapy
US8615309B2 (en) 2006-03-29 2013-12-24 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
JP5327542B2 (en) * 2006-09-28 2013-10-30 ウイスコンシン アラムナイ リサーチ ファウンデーシヨン Method and apparatus for promoting restorative sleep
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
US20080243204A1 (en) * 2007-03-28 2008-10-02 University Of Florida Research Foundation, Inc. Variational parameter neurostimulation paradigm for treatment of neurologic disease
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
WO2009012599A1 (en) * 2007-07-26 2009-01-29 Uti Limited Partnership Transient intervention for modifying the breathing of a patient
CN101888870B (en) * 2007-10-26 2013-11-27 优特埃合伙有限公司 Ventilation stabilization system
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US8195298B2 (en) * 2008-02-15 2012-06-05 Andres M Lozano Method for treating neurological/psychiatric disorders with stimulation to the subcaudate area of the brain
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
US9776008B2 (en) 2008-07-11 2017-10-03 Medtronic, Inc. Posture state responsive therapy delivery using dwell times
US9050471B2 (en) 2008-07-11 2015-06-09 Medtronic, Inc. Posture state display on medical device user interface
US8504150B2 (en) 2008-07-11 2013-08-06 Medtronic, Inc. Associating therapy adjustments with posture states using a stability timer
US8209028B2 (en) 2008-07-11 2012-06-26 Medtronic, Inc. Objectification of posture state-responsive therapy based on patient therapy adjustments
US8437861B2 (en) 2008-07-11 2013-05-07 Medtronic, Inc. Posture state redefinition based on posture data and therapy adjustments
US8708934B2 (en) 2008-07-11 2014-04-29 Medtronic, Inc. Reorientation of patient posture states for posture-responsive therapy
US8583252B2 (en) 2008-07-11 2013-11-12 Medtronic, Inc. Patient interaction with posture-responsive therapy
US9440084B2 (en) 2008-07-11 2016-09-13 Medtronic, Inc. Programming posture responsive therapy
US8326420B2 (en) 2008-07-11 2012-12-04 Medtronic, Inc. Associating therapy adjustments with posture states using stability timers
US8280517B2 (en) 2008-09-19 2012-10-02 Medtronic, Inc. Automatic validation techniques for validating operation of medical devices
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
EP2346567A4 (en) 2008-11-13 2012-04-25 Proteus Biomedical Inc Multiplexed multi-electrode neurostimulation devices
EP2349466A4 (en) 2008-11-13 2013-03-20 Proteus Digital Health Inc Shielded stimulation and sensing system and method
US20100191304A1 (en) 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
US9026223B2 (en) 2009-04-30 2015-05-05 Medtronic, Inc. Therapy system including multiple posture sensors
US8175720B2 (en) 2009-04-30 2012-05-08 Medtronic, Inc. Posture-responsive therapy control based on patient input
US9327070B2 (en) 2009-04-30 2016-05-03 Medtronic, Inc. Medical device therapy based on posture and timing
US8273380B1 (en) 2009-05-19 2012-09-25 Jetway Inc. Fortified beverage for minimizing and/or preventing jet lag
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US8579834B2 (en) 2010-01-08 2013-11-12 Medtronic, Inc. Display of detected patient posture state
US9357949B2 (en) 2010-01-08 2016-06-07 Medtronic, Inc. User interface that displays medical therapy and posture data
US8388555B2 (en) 2010-01-08 2013-03-05 Medtronic, Inc. Posture state classification for a medical device
US9956418B2 (en) 2010-01-08 2018-05-01 Medtronic, Inc. Graphical manipulation of posture zones for posture-responsive therapy
US9566441B2 (en) 2010-04-30 2017-02-14 Medtronic, Inc. Detecting posture sensor signal shift or drift in medical devices
US9907959B2 (en) 2012-04-12 2018-03-06 Medtronic, Inc. Velocity detection for posture-responsive therapy
US9737719B2 (en) 2012-04-26 2017-08-22 Medtronic, Inc. Adjustment of therapy based on acceleration
WO2014035966A1 (en) * 2012-08-28 2014-03-06 Ohio State Innovation Foundation Devices, systems, and methods for treating circadian rhythm disorders
US10485972B2 (en) 2015-02-27 2019-11-26 Thync Global, Inc. Apparatuses and methods for neuromodulation
US10814131B2 (en) 2012-11-26 2020-10-27 Thync Global, Inc. Apparatuses and methods for neuromodulation
US10537703B2 (en) 2012-11-26 2020-01-21 Thync Global, Inc. Systems and methods for transdermal electrical stimulation to improve sleep
US11033731B2 (en) 2015-05-29 2021-06-15 Thync Global, Inc. Methods and apparatuses for transdermal electrical stimulation
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US9056195B2 (en) 2013-03-15 2015-06-16 Cyberonics, Inc. Optimization of cranial nerve stimulation to treat seizure disorderse during sleep
US10293161B2 (en) 2013-06-29 2019-05-21 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
WO2015131093A1 (en) 2014-02-27 2015-09-03 Thync, Inc. Methods and apparatuses for user control of neurostimulation
US9302109B2 (en) 2014-04-25 2016-04-05 Cyberonics, Inc. Cranial nerve stimulation to treat depression during sleep
US9585611B2 (en) 2014-04-25 2017-03-07 Cyberonics, Inc. Detecting seizures based on heartbeat data
US10426945B2 (en) 2015-01-04 2019-10-01 Thync Global, Inc. Methods and apparatuses for transdermal stimulation of the outer ear
US11534608B2 (en) 2015-01-04 2022-12-27 Ist, Llc Methods and apparatuses for transdermal stimulation of the outer ear
WO2017106411A1 (en) 2015-12-15 2017-06-22 Cerevast Medical, Inc. Electrodes having surface exclusions
WO2017106878A1 (en) 2015-12-18 2017-06-22 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
US9956405B2 (en) 2015-12-18 2018-05-01 Thyne Global, Inc. Transdermal electrical stimulation at the neck to induce neuromodulation
US10646708B2 (en) 2016-05-20 2020-05-12 Thync Global, Inc. Transdermal electrical stimulation at the neck
US10786676B2 (en) * 2016-10-21 2020-09-29 Regents Of The University Of Minnesota Deep brain stimulation system and method with multi-modal, multi-symptom neuromodulation
US20180200513A1 (en) * 2017-01-18 2018-07-19 Boston Scientific Neuromodulation Corporation Modulation of the superior cervical ganglion for the treatment of insomnia
US11596795B2 (en) 2017-07-31 2023-03-07 Medtronic, Inc. Therapeutic electrical stimulation therapy for patient gait freeze
WO2019060298A1 (en) 2017-09-19 2019-03-28 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
WO2019133997A1 (en) 2017-12-31 2019-07-04 Neuroenhancement Lab, LLC System and method for neuroenhancement to enhance emotional response
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
US11278724B2 (en) 2018-04-24 2022-03-22 Thync Global, Inc. Streamlined and pre-set neuromodulators
EP3849410A4 (en) 2018-09-14 2022-11-02 Neuroenhancement Lab, LLC System and method of improving sleep
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
CN113005150A (en) * 2019-12-20 2021-06-22 复旦大学附属华山医院 Preparation method of novel animal rapid eye movement sleep behavior disorder model
AU2021224565A1 (en) * 2020-02-19 2022-08-18 Boston Scientific Neuromodulation Corporation Methods and systems for treatment of insomnia using deep brain stimulation
US11464977B2 (en) 2020-03-23 2022-10-11 Medtronic, Inc. Obstructive and central sleep apnea combination therapy control
CN114305335B (en) * 2021-12-24 2023-10-13 中国科学院空天信息创新研究院 Head-wearing type multi-brain-area nerve detection regulation and control micro-system and micro-nano electrode array module

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3762396A (en) * 1970-10-30 1973-10-02 United Biscuits Ltd Method and apparatus for inducing sleep by applying electrical pulses to plural portions of the head
US6194437B1 (en) * 1996-08-22 2001-02-27 Warner-Lambert Company Non-peptide bombesin receptor antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572165A (en) * 1982-12-03 1986-02-25 Jacques Dodier Hydrokinetic injector, particularly for balneotherapeutic applications
US5105354A (en) * 1989-01-23 1992-04-14 Nippon Kayaku Kabushiki Kaisha Method and apparatus for correlating respiration and heartbeat variability
US5335657A (en) * 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5697975A (en) 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
US6128537A (en) * 1997-05-01 2000-10-03 Medtronic, Inc Techniques for treating anxiety by brain stimulation and drug infusion
US6368331B1 (en) 1999-02-22 2002-04-09 Vtarget Ltd. Method and system for guiding a diagnostic or therapeutic instrument towards a target region inside the patient's body
US6356784B1 (en) * 1999-04-30 2002-03-12 Medtronic, Inc. Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus
US20020032375A1 (en) 2000-09-11 2002-03-14 Brainlab Ag Method and system for visualizing a body volume and computer program product
US6885886B2 (en) 2000-09-11 2005-04-26 Brainlab Ag Method and system for visualizing a body volume and computer program product
US6597953B2 (en) * 2001-02-20 2003-07-22 Neuropace, Inc. Furcated sensing and stimulation lead
US6606521B2 (en) * 2001-07-09 2003-08-12 Neuropace, Inc. Implantable medical lead
US6760626B1 (en) * 2001-08-29 2004-07-06 Birinder R. Boveja Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3762396A (en) * 1970-10-30 1973-10-02 United Biscuits Ltd Method and apparatus for inducing sleep by applying electrical pulses to plural portions of the head
US6194437B1 (en) * 1996-08-22 2001-02-27 Warner-Lambert Company Non-peptide bombesin receptor antagonists

Also Published As

Publication number Publication date
US8612005B2 (en) 2013-12-17
WO2003072186A2 (en) 2003-09-04
US20050177192A1 (en) 2005-08-11
AU2003241269A1 (en) 2003-09-09

Similar Documents

Publication Publication Date Title
WO2003072186A3 (en) Neurostimulation for affecting sleep disorders
AU2003264847A1 (en) Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders
WO2006029257A3 (en) Neurostimulation methods and systems
AU2003215065A8 (en) Method for treating diseases associated with abnormal kinase activity
WO2003041559A3 (en) Electrical stimulation of the sympathetic nerve chain
WO2003071927A3 (en) Diagnostics and therapeutics for macular degeneration-related disorders
WO2004096018A3 (en) Apparatus and methods of optimal placement of deep brain stimulator
SG138449A1 (en) Enumeration method for the link clock rate and the pixel/audio clock rate
EP1545700A4 (en) Methods for treating central nervous system damage
AU2002950878A0 (en) Method for diagnosing disorders
WO2008002917A3 (en) Systems and methods for promoting nerve regeneration
AU2003261371A8 (en) System and method for determinig the identity of a party associated with a transaction
WO2007003019A3 (en) Means for functional restoration of a damaged nervous system
AU2003279087A1 (en) Fuel-pump monitoring system and associated method
GB0312419D0 (en) Use of a compound in the treatment of sleep disorders and the like, in providing refreshedness on waking and a method for the treatment of grogginess
WO2004024150A3 (en) Mglu receptors antagonists for treating disorders associated with mglu receptors including addiction and depression
WO2004102322A8 (en) Method and apparatus for monitoring and treating medical signs and symptoms
IL180873A0 (en) Method for producing the enantiomer forms cis-configured 3-hydroxycyclohexane carboxylic acid derivatives using hydrolases
AU5208200A (en) Screwed connection, fastener for said connection and method for the production thereof
WO2003087054A3 (en) Methods for identifying compounds that modulate enzymatic activity
AU2003297281A1 (en) Methods for treating, preventing, or reducing cardiac disorders using fadd inhibitors
ZA200501670B (en) Methods for diagnosing dementia-related neurological disorders.
AU2003276071A1 (en) Decomposition-resistant polyamide and method for the production thereof
WO2004058154A3 (en) Method of identifying therapeutic agents
TW200407316A (en) Crystal forms of quinoxaline-2-carboxylic acid [4-carbamoyl-1-(3-fluorobenzyl)-2,7-dihydroxy-7-methyl-octyl]-amide

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2003241269

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 200550016

Country of ref document: ES

Kind code of ref document: A

122 Ep: pct application non-entry in european phase
WWE Wipo information: entry into national phase

Ref document number: 10502820

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP