WO2003092665A3 - Ocular drug delivery systems and use thereof - Google Patents

Ocular drug delivery systems and use thereof Download PDF

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Publication number
WO2003092665A3
WO2003092665A3 PCT/US2003/004645 US0304645W WO03092665A3 WO 2003092665 A3 WO2003092665 A3 WO 2003092665A3 US 0304645 W US0304645 W US 0304645W WO 03092665 A3 WO03092665 A3 WO 03092665A3
Authority
WO
WIPO (PCT)
Prior art keywords
aptamer
drug delivery
delivery systems
provides
ocular drug
Prior art date
Application number
PCT/US2003/004645
Other languages
French (fr)
Other versions
WO2003092665A2 (en
Inventor
Karen G Carrasquillo
Anthony Adamis
Original Assignee
Massachusetts Eye & Ear Infirm
Karen G Carrasquillo
Anthony Adamis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/139,656 external-priority patent/US7563255B2/en
Application filed by Massachusetts Eye & Ear Infirm, Karen G Carrasquillo, Anthony Adamis filed Critical Massachusetts Eye & Ear Infirm
Priority to AU2003217531A priority Critical patent/AU2003217531A1/en
Publication of WO2003092665A2 publication Critical patent/WO2003092665A2/en
Priority to US10/979,785 priority patent/US20050175708A1/en
Publication of WO2003092665A3 publication Critical patent/WO2003092665A3/en
Priority to US12/753,507 priority patent/US20100189801A1/en
Priority to US13/247,458 priority patent/US20120201859A1/en
Priority to US14/198,546 priority patent/US20140328937A1/en
Priority to US14/831,287 priority patent/US20160143844A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J14/00—Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to a scleral surface of an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.
PCT/US2003/004645 2002-05-02 2003-02-17 Ocular drug delivery systems and use thereof WO2003092665A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2003217531A AU2003217531A1 (en) 2002-05-02 2003-02-17 Ocular drug delivery systems and use thereof
US10/979,785 US20050175708A1 (en) 2002-05-02 2004-11-02 Drug delivery systems and use thereof
US12/753,507 US20100189801A1 (en) 2002-05-02 2010-04-02 Drug Delivery Systems and Use Thereof
US13/247,458 US20120201859A1 (en) 2002-05-02 2011-09-28 Drug Delivery Systems and Use Thereof
US14/198,546 US20140328937A1 (en) 2002-05-02 2014-03-05 Drug Delivery Systems and Use Thereof
US14/831,287 US20160143844A1 (en) 2002-05-02 2015-08-20 Drug Delivery Systems and Use Thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/139,656 2002-05-02
US10/139,656 US7563255B2 (en) 2001-05-03 2002-05-02 Implantable drug delivery device and use thereof
US43865103P 2003-01-08 2003-01-08
US60/438,651 2003-01-08

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/139,656 Continuation-In-Part US7563255B2 (en) 2001-05-03 2002-05-02 Implantable drug delivery device and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/979,785 Continuation-In-Part US20050175708A1 (en) 2002-05-02 2004-11-02 Drug delivery systems and use thereof

Publications (2)

Publication Number Publication Date
WO2003092665A2 WO2003092665A2 (en) 2003-11-13
WO2003092665A3 true WO2003092665A3 (en) 2009-06-18

Family

ID=29406267

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004645 WO2003092665A2 (en) 2002-05-02 2003-02-17 Ocular drug delivery systems and use thereof

Country Status (3)

Country Link
US (6) US20050175708A1 (en)
AU (1) AU2003217531A1 (en)
WO (1) WO2003092665A2 (en)

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