WO2004034880A3 - Timed delay for redelivery of treatment therapy for a medical device system - Google Patents

Timed delay for redelivery of treatment therapy for a medical device system Download PDF

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Publication number
WO2004034880A3
WO2004034880A3 PCT/US2003/032909 US0332909W WO2004034880A3 WO 2004034880 A3 WO2004034880 A3 WO 2004034880A3 US 0332909 W US0332909 W US 0332909W WO 2004034880 A3 WO2004034880 A3 WO 2004034880A3
Authority
WO
WIPO (PCT)
Prior art keywords
medical device
device system
signal data
during
seizure
Prior art date
Application number
PCT/US2003/032909
Other languages
French (fr)
Other versions
WO2004034880A2 (en
Inventor
Mark G Frei
Ivan Osorio
Naresh C Bhavaraju
David L Carlson
Jonathon E Giftakis
Nina M Graves
Original Assignee
Medtronic Inc
Mark G Frei
Ivan Osorio
Naresh C Bhavaraju
David L Carlson
Jonathon E Giftakis
Nina M Graves
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc, Mark G Frei, Ivan Osorio, Naresh C Bhavaraju, David L Carlson, Jonathon E Giftakis, Nina M Graves filed Critical Medtronic Inc
Priority to US10/687,567 priority Critical patent/US7282030B2/en
Priority to AU2003301256A priority patent/AU2003301256A1/en
Priority to EP03809098A priority patent/EP1558131A4/en
Publication of WO2004034880A2 publication Critical patent/WO2004034880A2/en
Publication of WO2004034880A3 publication Critical patent/WO2004034880A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/361—Phantom sensations, e.g. tinnitus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7217—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/92—Computer assisted medical diagnostics

Abstract

Apparatus (100) and method support a repetitive administration of a therapeutic treatment through a delivery unit (953) during a neurological event, such as a seizure, of a nervous system disorder. The medical device system monitors signal data from a sensor and through an amplifier. A neurological event is detected by a medical device system using a detection algorithm. Consequently, a electrical stimulation pulse is applied to an electrode. During the delivery of the electrical stimulation pulse, the medical device system blanks signal data that is associated with the electrode. Subsequently, additional blanking is providing during a time interval in which signal artifacts may occur and the amplifier is stabilizing. The medical device system then collects signal data for the detection algorithm to stabilize. Subsequently, the medical device system collects additional signal data in order to obtain statistically meaningful data. If the medical device system detects a continuation of the seizure, therapeutic treatment continues.
PCT/US2003/032909 2002-10-15 2003-10-15 Timed delay for redelivery of treatment therapy for a medical device system WO2004034880A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/687,567 US7282030B2 (en) 2002-10-15 2003-10-15 Timed delay for redelivery of treatment therapy for a medical device system
AU2003301256A AU2003301256A1 (en) 2002-10-15 2003-10-15 Timed delay for redelivery of treatment therapy for a medical device system
EP03809098A EP1558131A4 (en) 2002-10-15 2003-10-15 Timed delay for redelivery of treatment therapy for a medical device system

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41849602P 2002-10-15 2002-10-15
US41866602P 2002-10-15 2002-10-15
US60/418,666 2002-10-15
US50379403P 2003-09-19 2003-09-19
US50400003P 2003-09-19 2003-09-19
US60/504,000 2003-09-19

Publications (2)

Publication Number Publication Date
WO2004034880A2 WO2004034880A2 (en) 2004-04-29
WO2004034880A3 true WO2004034880A3 (en) 2004-07-22

Family

ID=38683551

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/032940 WO2004034882A2 (en) 2002-10-15 2003-10-15 Measuring a neurological event using clustering
PCT/US2003/032909 WO2004034880A2 (en) 2002-10-15 2003-10-15 Timed delay for redelivery of treatment therapy for a medical device system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/032940 WO2004034882A2 (en) 2002-10-15 2003-10-15 Measuring a neurological event using clustering

Country Status (4)

Country Link
US (2) US7282030B2 (en)
EP (2) EP1583464B1 (en)
AU (2) AU2003285895A1 (en)
WO (2) WO2004034882A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8855775B2 (en) 2006-11-14 2014-10-07 Cyberonics, Inc. Systems and methods of reducing artifact in neurological stimulation systems
US9289595B2 (en) 2009-01-09 2016-03-22 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
US9445730B2 (en) 2007-03-21 2016-09-20 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject

Families Citing this family (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US8762065B2 (en) 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US9320900B2 (en) 1998-08-05 2016-04-26 Cyberonics, Inc. Methods and systems for determining subject-specific parameters for a neuromodulation therapy
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US7209787B2 (en) 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7747325B2 (en) 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
US6678548B1 (en) * 2000-10-20 2004-01-13 The Trustees Of The University Of Pennsylvania Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device
US6892098B2 (en) * 2001-04-26 2005-05-10 Biocontrol Medical Ltd. Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders
US6907295B2 (en) 2001-08-31 2005-06-14 Biocontrol Medical Ltd. Electrode assembly for nerve control
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US7904176B2 (en) 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US7778703B2 (en) * 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US8571653B2 (en) 2001-08-31 2013-10-29 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation techniques
US7974693B2 (en) 2001-08-31 2011-07-05 Bio Control Medical (B.C.M.) Ltd. Techniques for applying, configuring, and coordinating nerve fiber stimulation
US7734355B2 (en) * 2001-08-31 2010-06-08 Bio Control Medical (B.C.M.) Ltd. Treatment of disorders by unidirectional nerve stimulation
US7885709B2 (en) 2001-08-31 2011-02-08 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation for treating disorders
US7778711B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Reduction of heart rate variability by parasympathetic stimulation
US7844346B2 (en) 2002-05-23 2010-11-30 Biocontrol Medical Ltd. Electrode assembly for nerve control
WO2004110550A2 (en) 2003-06-13 2004-12-23 Biocontrol Medical Ltd. Vagal stimulation for anti-embolic therapy
US7321793B2 (en) * 2003-06-13 2008-01-22 Biocontrol Medical Ltd. Vagal stimulation for atrial fibrillation therapy
US8204591B2 (en) 2002-05-23 2012-06-19 Bio Control Medical (B.C.M.) Ltd. Techniques for prevention of atrial fibrillation
US20040093191A1 (en) * 2002-11-12 2004-05-13 The Boeing Company System and method for performing modal analysis of at least one remote structure
US7627384B2 (en) 2004-11-15 2009-12-01 Bio Control Medical (B.C.M.) Ltd. Techniques for nerve stimulation
US8880192B2 (en) 2012-04-02 2014-11-04 Bio Control Medical (B.C.M.) Ltd. Electrode cuffs
US8060197B2 (en) 2003-05-23 2011-11-15 Bio Control Medical (B.C.M.) Ltd. Parasympathetic stimulation for termination of non-sinus atrial tachycardia
US20050143589A1 (en) * 2003-11-09 2005-06-30 Donoghue John P. Calibration systems and methods for neural interface devices
US7317941B2 (en) * 2003-11-13 2008-01-08 Medtronic, Inc. Time syncrhonization of data
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
EP1734941A2 (en) 2004-03-25 2006-12-27 The Feinstein Institute for Medical Research Neural tourniquet
JP5175092B2 (en) 2004-06-01 2013-04-03 クワラタ トレーディング リミティド In vitro technology using stem cells
JP5336078B2 (en) * 2004-09-01 2013-11-06 モナシュ ユニバーシティ Neural event processing
US7526340B2 (en) * 2004-10-29 2009-04-28 Medtronic, Inc. Division approximation for implantable medical devices
US7288066B2 (en) * 2004-11-01 2007-10-30 Medtronic, Inc. Data compression method for implantable medical devices
US8768446B2 (en) * 2004-11-02 2014-07-01 Medtronic, Inc. Clustering with combined physiological signals
US8024029B2 (en) * 2004-11-02 2011-09-20 Medtronic, Inc. Techniques for user-activated data retention in an implantable medical device
WO2006050524A1 (en) * 2004-11-02 2006-05-11 Medtronic, Inc. Techniques for data retention upon detection of an event in an implantable medical device
US7917199B2 (en) * 2004-11-02 2011-03-29 Medtronic, Inc. Patient event marking in combination with physiological signals
US20060129056A1 (en) * 2004-12-10 2006-06-15 Washington University Electrocorticography telemitter
US8209019B2 (en) * 2004-12-17 2012-06-26 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US8108038B2 (en) * 2004-12-17 2012-01-31 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain activity
US8214035B2 (en) * 2004-12-17 2012-07-03 Medtronic, Inc. System and method for utilizing brain state information to modulate cardiac therapy
US8112153B2 (en) 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US8112148B2 (en) 2004-12-17 2012-02-07 Medtronic, Inc. System and method for monitoring cardiac signal activity in patients with nervous system disorders
US8485979B2 (en) 2004-12-17 2013-07-16 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
US20070239230A1 (en) * 2004-12-17 2007-10-11 Medtronic, Inc. System and method for regulating cardiac triggered therapy to the brain
US8209009B2 (en) 2004-12-17 2012-06-26 Medtronic, Inc. System and method for segmenting a cardiac signal based on brain stimulation
US8108046B2 (en) * 2004-12-17 2012-01-31 Medtronic, Inc. System and method for using cardiac events to trigger therapy for treating nervous system disorders
WO2006066098A1 (en) * 2004-12-17 2006-06-22 Medtronic, Inc. System and method for monitoring or treating nervous system disorders
CN102793972A (en) 2004-12-27 2012-11-28 范因斯坦医学研究院 Treating inflammatory disorders by electrical vagus nerve stimulation
US11207518B2 (en) 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
US8609082B2 (en) 2005-01-25 2013-12-17 Bio Control Medical Ltd. Administering bone marrow progenitor cells or myoblasts followed by application of an electrical current for cardiac repair, increasing blood supply or enhancing angiogenesis
US20070055320A1 (en) * 2005-09-07 2007-03-08 Northstar Neuroscience, Inc. Methods for treating temporal lobe epilepsy, associated neurological disorders, and other patient functions
US8165682B2 (en) * 2005-09-29 2012-04-24 Uchicago Argonne, Llc Surface acoustic wave probe implant for predicting epileptic seizures
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8868172B2 (en) 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US7657310B2 (en) * 2006-01-26 2010-02-02 Cyberonics, Inc. Treatment of reproductive endocrine disorders by vagus nerve stimulation
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
US8190251B2 (en) * 2006-03-24 2012-05-29 Medtronic, Inc. Method and apparatus for the treatment of movement disorders
US20080269835A1 (en) * 2006-04-21 2008-10-30 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US7761146B2 (en) * 2006-04-21 2010-07-20 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US20070249953A1 (en) * 2006-04-21 2007-10-25 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US7764989B2 (en) * 2006-04-21 2010-07-27 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US20070249956A1 (en) * 2006-04-21 2007-10-25 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US7761145B2 (en) * 2006-04-21 2010-07-20 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US8165683B2 (en) * 2006-04-21 2012-04-24 Medtronic, Inc. Method and apparatus for detection of nervous system disorders
US7764988B2 (en) 2006-04-27 2010-07-27 Medtronic, Inc. Flexible memory management scheme for loop recording in an implantable device
US7610083B2 (en) * 2006-04-27 2009-10-27 Medtronic, Inc. Method and system for loop recording with overlapping events
US7359837B2 (en) * 2006-04-27 2008-04-15 Medtronic, Inc. Peak data retention of signal data in an implantable medical device
US7856272B2 (en) * 2006-04-28 2010-12-21 Flint Hills Scientific, L.L.C. Implantable interface for a medical device system
US20070299317A1 (en) * 2006-06-13 2007-12-27 Hoyme Kenneth P System and method for programming customized data collection for an autonomous medical device
EP2034885A4 (en) 2006-06-23 2010-12-01 Neurovista Corp Minimally invasive monitoring systems and methods
US11389232B2 (en) 2006-06-28 2022-07-19 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US9119633B2 (en) 2006-06-28 2015-09-01 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US20080058664A1 (en) * 2006-08-29 2008-03-06 Neuropace, Inc. Patient event recording and reporting apparatus, system, and method
US20090281518A1 (en) * 2006-09-13 2009-11-12 Koninklijke Philips Electronics N.V. Device for automatic adjustment of the dose of melatonin and/or delivery of melatonin
US9898656B2 (en) 2007-01-25 2018-02-20 Cyberonics, Inc. Systems and methods for identifying a contra-ictal condition in a subject
WO2008092133A2 (en) 2007-01-25 2008-07-31 Neurovista Corporation Methods and systems for measuring a subject's susceptibility to a seizure
US7904175B2 (en) 2007-04-26 2011-03-08 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US7962214B2 (en) 2007-04-26 2011-06-14 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7869884B2 (en) 2007-04-26 2011-01-11 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US8000788B2 (en) 2007-04-27 2011-08-16 Medtronic, Inc. Implantable medical device for treating neurological conditions including ECG sensing
WO2008133626A1 (en) * 2007-04-30 2008-11-06 Medtronic, Inc. Seizure prediction
US8594779B2 (en) * 2007-04-30 2013-11-26 Medtronic, Inc. Seizure prediction
US9788750B2 (en) * 2007-04-30 2017-10-17 Medtronic, Inc. Seizure prediction
US9521955B2 (en) * 2007-05-03 2016-12-20 Cornell Research Foundtion, Inc. Subdural electro-optical sensor
WO2008151077A2 (en) * 2007-06-01 2008-12-11 Cdl Nuclear Technologies, Inc. Method, apparatus and protocol for screening appropriate patient candidates and for cardiac resychronization therapy (crt), determining cardiac functional response to adjustments of ventricular pacing devices and follow-up of crt patient outcomes
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
WO2009029614A1 (en) 2007-08-27 2009-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
US10561845B2 (en) 2007-09-24 2020-02-18 Medtronic, Inc. Therapy adjustment based on patient event indication
US8376943B2 (en) * 2007-09-24 2013-02-19 Medtronic, Inc. Patient event information
US9529972B2 (en) * 2007-09-24 2016-12-27 Medtronic, Inc. Patient event indication
US20090093686A1 (en) * 2007-10-08 2009-04-09 Xiao Hu Multi Automated Severity Scoring
WO2009046764A1 (en) * 2007-10-10 2009-04-16 Neurotech S.A. Neurostimulator and method for regulting the same
US8906011B2 (en) 2007-11-16 2014-12-09 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
ES2593091T3 (en) 2007-12-12 2016-12-05 Cardiac Pacemakers, Inc. Implantable medical device with Hall sensor
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8571643B2 (en) 2010-09-16 2013-10-29 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
WO2009140283A1 (en) * 2008-05-13 2009-11-19 The Board Of Trustees Of The University Of Illinois Apparatus for managing a neurological disorder
WO2010014686A1 (en) 2008-07-30 2010-02-04 Aleva Neurotherapeutics, S.A. Apparatus and method for optimized stimulation of a neurological target
US8280516B2 (en) 2008-10-09 2012-10-02 Daniel Graupe Method and apparatus for closed-loop deep brain stimulation in treating neurological diseases
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
EP2604313B1 (en) 2008-11-12 2014-09-17 Ecole Polytechnique Federale de Lausanne Microfabricated neurostimulation device
WO2010059617A2 (en) 2008-11-18 2010-05-27 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8239028B2 (en) 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US9155885B2 (en) 2009-04-24 2015-10-13 Medtronic, Inc. Incontinence therapy
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
CN102413871B (en) * 2009-04-30 2016-01-20 麦德托尼克公司 To detect based on the patient condition based on the algorithm of support vector machine
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8649860B2 (en) 2009-05-27 2014-02-11 Cardiac Pacemakers, Inc. Adaptive event storage in implantable device
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
CN102573986B (en) 2009-06-09 2016-01-20 赛博恩特医疗器械公司 For the nerve cuff with bag portion without wire stimulator
US8374701B2 (en) * 2009-07-28 2013-02-12 The Invention Science Fund I, Llc Stimulating a nervous system component of a mammal in response to contactlessly acquired information
US8942817B2 (en) * 2009-07-28 2015-01-27 The Invention Science Fund I, Llc Broadcasting a signal indicative of a disease, disorder, or symptom determined in response to contactlessly acquired information
US9697336B2 (en) 2009-07-28 2017-07-04 Gearbox, Llc Electronically initiating an administration of a neuromodulation treatment regimen chosen in response to contactlessly acquired information
US8346354B2 (en) * 2009-07-28 2013-01-01 The Invention Science Fund I, Llc Determining a neuromodulation treatment regimen in response to contactlessly acquired information
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
WO2014169145A1 (en) 2013-04-10 2014-10-16 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
JP2013512062A (en) 2009-12-01 2013-04-11 エコーレ ポリテクニーク フェデラーレ デ ローザンヌ Microfabricated surface nerve stimulation device and methods of making and using the same
WO2011079309A2 (en) 2009-12-23 2011-06-30 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
AU2011234422B2 (en) 2010-04-01 2015-11-05 Ecole Polytechnique Federale De Lausanne (Epfl) Device for interacting with neurological tissue and methods of making and using the same
US8296108B2 (en) * 2010-04-02 2012-10-23 Yugen Kaisha Suwa Torasuto Time series data analyzer, and a computer-readable recording medium recording a time series data analysis program
US8874229B2 (en) * 2010-04-28 2014-10-28 Cyberonics, Inc. Delivering scheduled and unscheduled therapy without detriment to battery life or accuracy of longevity predictions
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
AU2011245315B2 (en) 2010-04-29 2014-02-27 Cyberonics, Inc. Methods for detecting a seizure from cardiac data
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
US10321841B2 (en) 2010-05-26 2019-06-18 Flint Hills Scientific, Llc Quantitative multivariate analysis of seizures
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US8951192B2 (en) * 2010-06-15 2015-02-10 Flint Hills Scientific, Llc Systems approach to disease state and health assessment
JP5711363B2 (en) * 2010-06-16 2015-04-30 カーディアック ペースメイカーズ， インコーポレイテッド Automatic nerve stimulation titration sweep
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
US9669226B2 (en) 2010-09-07 2017-06-06 Empi, Inc. Methods and systems for reducing interference in stimulation treatment
JP5710767B2 (en) 2010-09-28 2015-04-30 マシモ コーポレイション Depth of consciousness monitor including oximeter
US8805519B2 (en) 2010-09-30 2014-08-12 Nevro Corporation Systems and methods for detecting intrathecal penetration
US8562524B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing a risk of death in epilepsy
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US8562523B2 (en) 2011-03-04 2013-10-22 Flint Hills Scientific, Llc Detecting, assessing and managing extreme epileptic events
US8565886B2 (en) 2010-11-10 2013-10-22 Medtronic, Inc. Arousal state modulation with electrical stimulation
US9504390B2 (en) 2011-03-04 2016-11-29 Globalfoundries Inc. Detecting, assessing and managing a risk of death in epilepsy
US9002390B2 (en) 2011-04-08 2015-04-07 Dexcom, Inc. Systems and methods for processing and transmitting sensor data
CN103501855B (en) 2011-04-20 2015-12-23 美敦力公司 The parameter of electricity treatment is determined based on bioelectric resonance response
US9173609B2 (en) 2011-04-20 2015-11-03 Medtronic, Inc. Brain condition monitoring based on co-activation of neural networks
EP2699310B1 (en) 2011-04-20 2018-09-19 Medtronic, Inc. Apparatus for assessing neural activation
US8892207B2 (en) 2011-04-20 2014-11-18 Medtronic, Inc. Electrical therapy for facilitating inter-area brain synchronization
US8725239B2 (en) 2011-04-25 2014-05-13 Cyberonics, Inc. Identifying seizures using heart rate decrease
US8812098B2 (en) 2011-04-28 2014-08-19 Medtronic, Inc. Seizure probability metrics
US9878161B2 (en) 2011-04-29 2018-01-30 Medtronic, Inc. Entrainment of bioelectrical brain signals
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection
EP2707094B1 (en) 2011-05-09 2016-02-03 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US20130172774A1 (en) * 2011-07-01 2013-07-04 Neuropace, Inc. Systems and Methods for Assessing the Effectiveness of a Therapy Including a Drug Regimen Using an Implantable Medical Device
US9888861B2 (en) 2011-08-25 2018-02-13 Medtronic, Inc. Method and apparatus for detecting a biomarker in the presence of electrical stimulation
US10206591B2 (en) * 2011-10-14 2019-02-19 Flint Hills Scientific, Llc Seizure detection methods, apparatus, and systems using an autoregression algorithm
JP6175447B2 (en) * 2011-12-16 2017-08-02 コーデイト・メディカル・アクチエボラーグＣｈｏｒｄａｔｅ Ｍｅｄｉｃａｌ ＡＢ Double stimulation
WO2013087886A1 (en) * 2011-12-16 2013-06-20 Chordate Medical Ag Device for stimulation of hypothalamus
WO2013087885A1 (en) 2011-12-16 2013-06-20 Chordate Medical Ag Device for treatment of headache disorders
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US10448839B2 (en) 2012-04-23 2019-10-22 Livanova Usa, Inc. Methods, systems and apparatuses for detecting increased risk of sudden death
US8918176B2 (en) 2012-04-23 2014-12-23 Medtronic, Inc. Assessing cognitive disorders based on non-motor epileptiform bioelectrical brain activity
US9198592B2 (en) 2012-05-21 2015-12-01 Kardium Inc. Systems and methods for activating transducers
US10827977B2 (en) 2012-05-21 2020-11-10 Kardium Inc. Systems and methods for activating transducers
US9017320B2 (en) 2012-05-21 2015-04-28 Kardium, Inc. Systems and methods for activating transducers
US10220211B2 (en) 2013-01-22 2019-03-05 Livanova Usa, Inc. Methods and systems to diagnose depression
US9056195B2 (en) 2013-03-15 2015-06-16 Cyberonics, Inc. Optimization of cranial nerve stimulation to treat seizure disorderse during sleep
US9370660B2 (en) 2013-03-29 2016-06-21 Rainbow Medical Ltd. Independently-controlled bidirectional nerve stimulation
US9092552B2 (en) 2013-04-26 2015-07-28 Cyberonics, Inc. System monitor for monitoring functional modules of a system
WO2014189770A2 (en) * 2013-05-15 2014-11-27 Zephyr Technology Corporation Two-electrode, impedance-based respiration determination
CN104225784A (en) * 2013-06-14 2014-12-24 刘东麒 Long-distance digital electrical-stimulation prescription system
US9974470B2 (en) 2013-11-07 2018-05-22 Dexcom, Inc. Systems and methods for a continuous monitoring of analyte values
US9585611B2 (en) 2014-04-25 2017-03-07 Cyberonics, Inc. Detecting seizures based on heartbeat data
US9302109B2 (en) 2014-04-25 2016-04-05 Cyberonics, Inc. Cranial nerve stimulation to treat depression during sleep
US11311718B2 (en) 2014-05-16 2022-04-26 Aleva Neurotherapeutics Sa Device for interacting with neurological tissue and methods of making and using the same
CN106455985B (en) 2014-05-16 2019-09-17 阿莱瓦神经治疗股份有限公司 With the device and production and preparation method thereof of nerve fiber interaction
JP6857499B2 (en) 2014-05-27 2021-04-14 レスメド・インコーポレイテッド Management of remote respiratory therapy equipment
US9403011B2 (en) 2014-08-27 2016-08-02 Aleva Neurotherapeutics Leadless neurostimulator
US9474894B2 (en) 2014-08-27 2016-10-25 Aleva Neurotherapeutics Deep brain stimulation lead
WO2016057553A1 (en) 2014-10-07 2016-04-14 Masimo Corporation Modular physiological sensors
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US10722184B2 (en) 2014-11-17 2020-07-28 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US10368936B2 (en) 2014-11-17 2019-08-06 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10130813B2 (en) 2015-02-10 2018-11-20 Neuropace, Inc. Seizure onset classification and stimulation parameter selection
US10105540B2 (en) 2015-11-09 2018-10-23 Bluewind Medical Ltd. Optimization of application of current
US10485471B2 (en) 2016-01-07 2019-11-26 The Trustees Of Dartmouth College System and method for identifying ictal states in a patient
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
WO2017127756A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Control of vagal stimulation
WO2017127758A1 (en) 2016-01-20 2017-07-27 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
CN109069824B (en) 2016-02-02 2022-09-16 阿莱瓦神经治疗股份有限公司 Treatment of autoimmune diseases using deep brain stimulation
US11045649B2 (en) 2016-02-19 2021-06-29 Medtronic, Inc. Incontinence therapy
EP3532154B1 (en) 2016-10-28 2023-08-23 Medtronic, Inc. Autotitration of therapy using detected electrical activity
CN107440704A (en) 2016-11-26 2017-12-08 张霞玲 A kind of adjustable neurostimulation probe in direction
WO2018120096A1 (en) 2016-12-30 2018-07-05 Medtrum Technologies Inc. System and method for algorithm adjustment applying motion sensors in cgm system
WO2018165391A1 (en) 2017-03-09 2018-09-13 Nevro Corp. Paddle leads and delivery tools, and associated systems and methods
US20200178832A1 (en) * 2017-05-25 2020-06-11 Brent M. Berry Seizure onset zone localization
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
WO2019060298A1 (en) 2017-09-19 2019-03-28 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US10729907B2 (en) 2017-10-20 2020-08-04 Neuropace, Inc. Systems and methods for clinical decision making for a patient receiving a neuromodulation therapy based on deep learning
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US10702692B2 (en) 2018-03-02 2020-07-07 Aleva Neurotherapeutics Neurostimulation device
EP3758793A4 (en) 2018-03-29 2021-12-08 Nevro Corp. Leads having sidewall openings, and associated systems and methods
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
WO2020056418A1 (en) 2018-09-14 2020-03-19 Neuroenhancement Lab, LLC System and method of improving sleep
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US11481578B2 (en) 2019-02-22 2022-10-25 Neuropace, Inc. Systems and methods for labeling large datasets of physiological records based on unsupervised machine learning
US11612750B2 (en) 2019-03-19 2023-03-28 Neuropace, Inc. Methods and systems for optimizing therapy using stimulation mimicking natural seizures
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
WO2021236977A1 (en) 2020-05-21 2021-11-25 The Feinstein Institutes For Medical Research Systems and methods for vagus nerve stimulation
WO2023015046A1 (en) * 2021-08-03 2023-02-09 Icahn School Of Medicine At Mount Sinai System to identify transitions in brain states from electrophysiological markers in dbs for depression
CN116226605B (en) * 2023-04-25 2023-07-25 北京领创医谷科技发展有限责任公司 Fitting method and system for stimulator parameters

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6366814B1 (en) * 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6587727B2 (en) * 1999-04-30 2003-07-01 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
US6597954B1 (en) * 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6609030B1 (en) * 2000-02-24 2003-08-19 Electrocore Techniques, Llc Method of treating psychiatric diseases by neuromodulation within the dorsomedial thalamus

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH480697A (en) 1967-07-18 1969-10-31 Robot Foto Electr Kg Photographic traffic monitoring device
US3522811A (en) * 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
US3967616A (en) 1972-10-24 1976-07-06 Ross Sidney A Multichannel system for and a multifactorial method of controlling the nervous system of a living organism
US3850161A (en) 1973-04-09 1974-11-26 S Liss Method and apparatus for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures and the like
US3863625A (en) 1973-11-02 1975-02-04 Us Health Epileptic seizure warning system
US3993046A (en) 1974-11-06 1976-11-23 Heriberto Fernandez Seizure suppression device
US4019518A (en) 1975-08-11 1977-04-26 Medtronic, Inc. Electrical stimulation system
US4038536A (en) 1976-03-29 1977-07-26 Rockwell International Corporation Adaptive recursive least mean square error filter
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4295474A (en) 1979-10-02 1981-10-20 The Johns Hopkins University Recorder with patient alarm and service request systems suitable for use with automatic implantable defibrillator
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US4417592A (en) 1981-05-11 1983-11-29 Roy John E Digital electroencephalographic instrument and method
US4566464A (en) 1981-07-27 1986-01-28 Piccone Vincent A Implantable epilepsy monitor apparatus
US4610259A (en) 1983-08-31 1986-09-09 Cns, Inc. EEG signal analysis system
US4702254A (en) 1983-09-14 1987-10-27 Jacob Zabara Neurocybernetic prosthesis
US4581758A (en) 1983-11-04 1986-04-08 At&T Bell Laboratories Acoustic direction identification system
US4873981A (en) * 1988-10-14 1989-10-17 Somatics, Inc. Electroconvulsive therapy apparatus and method for automatic monitoring of patient seizures
US4944299A (en) 1989-08-08 1990-07-31 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable device
US4974589A (en) 1989-10-17 1990-12-04 Siemens-Pacesetter, Inc. Automatically adjustable blanking period for implantable pacemaker
US5311869A (en) * 1990-03-24 1994-05-17 Kabushiki Kaisha Toshiba Method and apparatus for ultrasonic wave treatment in which medical progress may be evaluated
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
MY117259A (en) * 1991-05-02 2004-06-30 Thomson Consumer Electronics Autoprogrammed channel mapping for a videocassette recorder.
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5431691A (en) 1992-03-02 1995-07-11 Siemens Pacesetter, Inc. Method and system for recording and displaying a sequential series of pacing events
US5311876A (en) 1992-11-18 1994-05-17 The Johns Hopkins University Automatic detection of seizures using electroencephalographic signals
US5318591A (en) 1992-11-23 1994-06-07 Siemens Pacesetter, Inc. Implantable cardioverter-defibrillator having early charging capability
US6117066A (en) 1992-12-04 2000-09-12 Somatics, Inc. Prevention of seizure arising from medical magnetoictal non-convulsive stimulation therapy
US5458619A (en) 1993-11-29 1995-10-17 Medtronic, Inc. Apparatus and method for treating a tachyarrhythmia
US6083248A (en) 1995-06-23 2000-07-04 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US5752976A (en) 1995-06-23 1998-05-19 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US5720770A (en) 1995-10-06 1998-02-24 Pacesetter, Inc. Cardiac stimulation system with enhanced communication and control capability
US6480743B1 (en) 2000-04-05 2002-11-12 Neuropace, Inc. System and method for adaptive brain stimulation
US5995868A (en) * 1996-01-23 1999-11-30 University Of Kansas System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
US6066163A (en) 1996-02-02 2000-05-23 John; Michael Sasha Adaptive brain stimulation method and system
US5857978A (en) * 1996-03-20 1999-01-12 Lockheed Martin Energy Systems, Inc. Epileptic seizure prediction by non-linear methods
US5626145A (en) 1996-03-20 1997-05-06 Lockheed Martin Energy Systems, Inc. Method and apparatus for extraction of low-frequency artifacts from brain waves for alertness detection
US5743860A (en) 1996-03-20 1998-04-28 Lockheed Martin Energy Systems, Inc. Apparatus and method for epileptic seizure detection using non-linear techniques
US5713922A (en) 1996-04-25 1998-02-03 Medtronic, Inc. Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain
US5683422A (en) 1996-04-25 1997-11-04 Medtronic, Inc. Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5716377A (en) 1996-04-25 1998-02-10 Medtronic, Inc. Method of treating movement disorders by brain stimulation
US6094598A (en) 1996-04-25 2000-07-25 Medtronics, Inc. Method of treating movement disorders by brain stimulation and drug infusion
US5713923A (en) 1996-05-13 1998-02-03 Medtronic, Inc. Techniques for treating epilepsy by brain stimulation and drug infusion
US6128537A (en) 1997-05-01 2000-10-03 Medtronic, Inc Techniques for treating anxiety by brain stimulation and drug infusion
US6427086B1 (en) 1997-10-27 2002-07-30 Neuropace, Inc. Means and method for the intracranial placement of a neurostimulator
US6230049B1 (en) 1999-08-13 2001-05-08 Neuro Pace, Inc. Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes
US6016449A (en) 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US6459936B2 (en) 1997-10-27 2002-10-01 Neuropace, Inc. Methods for responsively treating neurological disorders
US6647296B2 (en) 1997-10-27 2003-11-11 Neuropace, Inc. Implantable apparatus for treating neurological disorders
US6227203B1 (en) 1998-02-12 2001-05-08 Medtronic, Inc. Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion
JP3365298B2 (en) * 1998-02-27 2003-01-08 松下電器産業株式会社 Video signal recording and playback device
US6018682A (en) 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system
US6374140B1 (en) 1998-04-30 2002-04-16 Medtronic, Inc. Method and apparatus for treating seizure disorders by stimulating the olfactory senses
US6366813B1 (en) 1998-08-05 2002-04-02 Dilorenzo Daniel J. Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease
US6658287B1 (en) 1998-08-24 2003-12-02 Georgia Tech Research Corporation Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity
US6385479B1 (en) 1999-03-31 2002-05-07 Science & Technology Corporation @ Unm Method for determining activity in the central nervous system
US6167308A (en) 1999-04-09 2000-12-26 Medtronic, Inc. Closed loop ATP
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6224549B1 (en) 1999-04-20 2001-05-01 Nicolet Biomedical, Inc. Medical signal monitoring and display
US6356784B1 (en) 1999-04-30 2002-03-12 Medtronic, Inc. Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus
US6923784B2 (en) 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6560486B1 (en) 1999-10-12 2003-05-06 Ivan Osorio Bi-directional cerebral interface system
US6473639B1 (en) 2000-03-02 2002-10-29 Neuropace, Inc. Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures
US6466822B1 (en) 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
US6353754B1 (en) 2000-04-24 2002-03-05 Neuropace, Inc. System for the creation of patient specific templates for epileptiform activity detection
JP2001331677A (en) 2000-05-18 2001-11-30 Koto Jimusho:Kk Person searching method using communication means and server (device) that can be applied to the same method
EP1296744A2 (en) 2000-06-23 2003-04-02 Medtronic, Inc. Network compatible rf wireless link for medical device data management
US6591138B1 (en) 2000-08-31 2003-07-08 Neuropace, Inc. Low frequency neurostimulator for the treatment of neurological disorders
US6678548B1 (en) 2000-10-20 2004-01-13 The Trustees Of The University Of Pennsylvania Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device
US6810285B2 (en) * 2001-06-28 2004-10-26 Neuropace, Inc. Seizure sensing and detection using an implantable device
US7149572B2 (en) * 2002-10-15 2006-12-12 Medtronic, Inc. Phase shifting of neurological signals in a medical device system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6597954B1 (en) * 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6366814B1 (en) * 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6587727B2 (en) * 1999-04-30 2003-07-01 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
US6609030B1 (en) * 2000-02-24 2003-08-19 Electrocore Techniques, Llc Method of treating psychiatric diseases by neuromodulation within the dorsomedial thalamus

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8855775B2 (en) 2006-11-14 2014-10-07 Cyberonics, Inc. Systems and methods of reducing artifact in neurological stimulation systems
US9445730B2 (en) 2007-03-21 2016-09-20 Cyberonics, Inc. Implantable systems and methods for identifying a contra-ictal condition in a subject
US9289595B2 (en) 2009-01-09 2016-03-22 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices

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