WO2004058329A3 - Ester combination local anesthetic - Google Patents

Ester combination local anesthetic Download PDF

Info

Publication number
WO2004058329A3
WO2004058329A3 PCT/US2003/041219 US0341219W WO2004058329A3 WO 2004058329 A3 WO2004058329 A3 WO 2004058329A3 US 0341219 W US0341219 W US 0341219W WO 2004058329 A3 WO2004058329 A3 WO 2004058329A3
Authority
WO
WIPO (PCT)
Prior art keywords
provides
ester
present
local anesthetic
ester combination
Prior art date
Application number
PCT/US2003/041219
Other languages
French (fr)
Other versions
WO2004058329A2 (en
Inventor
Steven L Shafer
Original Assignee
Univ Leland Stanford Junior
Steven L Shafer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Steven L Shafer filed Critical Univ Leland Stanford Junior
Priority to EP03800157A priority Critical patent/EP1572218A4/en
Priority to MXPA05006771A priority patent/MXPA05006771A/en
Priority to AU2003299885A priority patent/AU2003299885A1/en
Priority to JP2004564039A priority patent/JP2006513224A/en
Priority to BR0317519-7A priority patent/BR0317519A/en
Priority to CA002507511A priority patent/CA2507511A1/en
Publication of WO2004058329A2 publication Critical patent/WO2004058329A2/en
Publication of WO2004058329A3 publication Critical patent/WO2004058329A3/en
Priority to NO20053203A priority patent/NO20053203L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/625—Salicylic acid; Derivatives thereof having heterocyclic substituents, e.g. 4-salicycloylmorpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

The present invention provides compositions and methods for improved local anesthesia and/or analgesia, in which onset of action is rapid, the risk of toxicity is low, and the effect is sustained. More particularly, the present invention provides a combination of at least two ester anesthetics for administration to a subject, where at least one ester anesthetic provides a rapid onset of action and at least one ester anesthetic provides sustained activity. The compositions of the present invention are useful for the production of analgesia and/or anesthesia and are particularly useful for the prophylaxis and/or treatment of pain.
PCT/US2003/041219 2002-12-20 2003-12-18 Ester combination local anesthetic WO2004058329A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP03800157A EP1572218A4 (en) 2002-12-20 2003-12-18 Ester combination local anesthetic
MXPA05006771A MXPA05006771A (en) 2002-12-20 2003-12-18 Ester combination local anesthetic.
AU2003299885A AU2003299885A1 (en) 2002-12-20 2003-12-18 Ester combination local anesthetic
JP2004564039A JP2006513224A (en) 2002-12-20 2003-12-18 Ester local anesthetic combinations
BR0317519-7A BR0317519A (en) 2002-12-20 2003-12-18 Pharmaceutical composition for local anesthesia and its use
CA002507511A CA2507511A1 (en) 2002-12-20 2003-12-18 Ester combination local anesthetic
NO20053203A NO20053203L (en) 2002-12-20 2005-06-30 Combination of local ester anesthetics.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32731002A 2002-12-20 2002-12-20
US10/327,310 2002-12-20

Publications (2)

Publication Number Publication Date
WO2004058329A2 WO2004058329A2 (en) 2004-07-15
WO2004058329A3 true WO2004058329A3 (en) 2004-12-29

Family

ID=32680753

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/041219 WO2004058329A2 (en) 2002-12-20 2003-12-18 Ester combination local anesthetic

Country Status (10)

Country Link
EP (1) EP1572218A4 (en)
JP (1) JP2006513224A (en)
KR (1) KR20050085736A (en)
CN (1) CN1729004A (en)
AU (1) AU2003299885A1 (en)
BR (1) BR0317519A (en)
CA (1) CA2507511A1 (en)
MX (1) MXPA05006771A (en)
NO (1) NO20053203L (en)
WO (1) WO2004058329A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060062836A1 (en) * 2004-09-21 2006-03-23 Carter Stephen G Methods of device-assisted drug delivery
NZ552862A (en) 2005-03-15 2009-03-31 Animal Ethics Pty Ltd A topical analgesic composition
ITMI20051633A1 (en) * 2005-09-06 2007-03-07 Sint Sa NEW USE OF A COMPOSITION INCLUDING CHOROPROCAINE HCL NEW COMPOSITION INCLUDING CHLOROPROCAINE HCL AND METHOD FOR ITS MANUFACTURING
AU2007275200A1 (en) * 2006-07-19 2008-01-24 Pharmacofore, Inc. Anesthetic compounds
US20080220062A1 (en) * 2006-10-23 2008-09-11 Psivida, Inc. Sustained release of agents for localized pain management
WO2009091546A1 (en) * 2008-01-18 2009-07-23 Pharmacofore, Inc. Anesthetic compounds
ITMI20122120A1 (en) * 2012-12-12 2014-06-13 Sint Sa PHARMACEUTICAL COMPOSITION BASED ON CHLOROPROCAIN FOR REPEATED INTRATECAL ADMINISTRATION
ITCR20130004A1 (en) * 2013-02-05 2014-08-06 Vincenzo Vigna SALVAVITA DRUG
US10117847B2 (en) * 2015-12-04 2018-11-06 Ventis Pharma Extended duration local anesthetic formulation
DE102016215037A1 (en) 2016-08-11 2018-02-15 Franz Baur Spring device and connecting device
CR20200133A (en) * 2017-09-15 2020-05-09 Sintetica S A Topical formulations of chloroprocaine
WO2019226599A1 (en) * 2018-05-22 2019-11-28 Alkalidx, Inc. Diagnostics and treatments of anesthetic insensitive subjects
JP6886551B1 (en) * 2020-11-06 2021-06-16 医療法人祥和会 Local anesthetic for dentistry

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326020B1 (en) * 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US7273887B1 (en) * 1999-10-22 2007-09-25 Transdermatech, Inc. Topical anesthetic formulation
US6383511B1 (en) * 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US20020006435A1 (en) * 2000-01-27 2002-01-17 Samuels Paul J. Transdermal anesthetic and vasodilator composition and methods for topical administration

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326020B1 (en) * 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1572218A4 *

Also Published As

Publication number Publication date
EP1572218A2 (en) 2005-09-14
CA2507511A1 (en) 2004-07-15
AU2003299885A1 (en) 2004-07-22
BR0317519A (en) 2005-11-16
CN1729004A (en) 2006-02-01
EP1572218A4 (en) 2007-05-16
KR20050085736A (en) 2005-08-29
JP2006513224A (en) 2006-04-20
NO20053203D0 (en) 2005-06-30
WO2004058329A2 (en) 2004-07-15
NO20053203L (en) 2005-09-19
MXPA05006771A (en) 2005-09-08

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