WO2004058349A1 - Device for electrically stimulating stomach - Google Patents
Device for electrically stimulating stomach Download PDFInfo
- Publication number
- WO2004058349A1 WO2004058349A1 PCT/JP2003/016065 JP0316065W WO2004058349A1 WO 2004058349 A1 WO2004058349 A1 WO 2004058349A1 JP 0316065 W JP0316065 W JP 0316065W WO 2004058349 A1 WO2004058349 A1 WO 2004058349A1
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- WIPO (PCT)
- Prior art keywords
- stimulation
- coil
- gastroparesis
- gastric
- long
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
Definitions
- the present invention relates to an electric stomach stimulator used for treatment of patients with gastroparesis.
- This device is particularly useful as a treatment device for gastroparesis patients whose vagus nerve has been cut.
- Gastroparesis various translations such as gastroparesis and gastric stagnation have been proposed, but here gastroparesis is a type). It is a chronic stomach dysfunction that causes a delay (Hornbuckle K, Barnett JL (2000) J Clin Gastroenterol, 30, 117-124). Gastroparesis is caused by amputation of the vagus nerve and diabetes, as well as those of unknown cause (idiopathic gastroparesis). Gastroparesis is complicatedly related to various disease states, but is deeply related to abnormalities in gastric myoelectrical activity (GMA), such as increased rhythm disturbances and reduced frequency of spike bursts.
- GMA gastric myoelectrical activity
- the devices for electrical stimulation of the stomach that have been used up to now, like many implantable pacemakers, have a circuit that generates a stimulation waveform and a battery that is a power supply embedded in the body. Reoperation is necessary.
- the primary target patient for gastric electrical stimulation is the elderly, and such devices, which require regular surgery, place a heavy burden on patients.
- IGFJ Intrinsic gastric slow wave frequency
- SPS short pulse stimulation
- IGFJ Intrinsic gastric slow wave frequency
- stimulation with a pulse width of 300 ms or more at ti frequency Bellahsene BE, Lind CD, Schirmer BD, et al. (1992) Am J Physiol, 262 , G826-834 Forster J, Sarosiek I, Delcore R, et al. (2001) Am J Surg, 182,676-681, G.EMS Study Group.
- the above-mentioned problem of power shortage in reoperation or long pulse stimulation due to battery exhaustion can be solved by embedding only a circuit for generating a stimulation waveform in the body, providing a power supply outside the body, and supplying power via a conductor.
- the conducting wire penetrates the skin, and there is a possibility that bacteria or the like may be transmitted from the penetrating portion.
- Patent Document 1 Patent No. 2710864
- Patent Document 2 U.S. Pat.No. 6,115,635
- the conventional gastric electrical stimulator imposes a heavy burden on the patient, and it was virtually impossible to apply long pulse stimulation.
- the present invention has been made in view of the above technical background, and an object of the present invention is to provide an electric stomach stimulator that can reduce the burden on a patient and can apply long-pulse stimulation.
- the present inventor has conducted intensive studies to solve the above-mentioned problems, and as a result, by supplying power to a device implanted in the body by a percutaneous power transmission system, the need for reoperation for battery replacement is eliminated. It was also found that long-pulse stimulation can be applied for a long time. The present inventors have also found that long pulse stimulation is very effective as a therapeutic tool for patients with gastroparesis in which the vagus nerve is severed. did. The present invention has been completed based on the above findings.
- the present invention includes the following (A) to (D).
- A (1) an oscillator disposed outside the body, (2) an external coil connected to the oscillator, (3) an internal coil embedded in the body and receiving power from the external coil by transcutaneous power transmission, ( 4) A waveform shaping circuit connected to the internal coil, and (5) an electric stomach stimulator having an electrode arranged in contact with the stomach wall and connected to the waveform shaping circuit.
- the stomach stimulator of the present invention has an oscillator, an extracorporeal coil, an intracorporeal coil, a waveform shaping circuit, and electrodes.
- the oscillator is not particularly limited as long as it can generate a current capable of providing an effective stimulus to the stomach.
- the extracorporeal coil is not particularly limited as long as it can transmit electric power to the internal coil. Further, the internal coil is not particularly limited as long as it can receive power from the external coil.
- the shape of the coil may be, for example, a planar coil having an outer diameter of 25 to 35 mm, an inner diameter of 0 to 20 mm, and a thickness of about 0.4 to 0.6 mm, but is not limited thereto. Copper wire of about O.lnmi can be used for the wire. Also, the number of turns of the coil can be 250 to 400, but is not limited to this.
- the surface of the coil is preferably coated with silicon or the like for waterproofing.
- the extracorporeal coil and the intracorporeal coil may have the same shape or may be different. Ferrite may be installed near the coil to improve the efficiency of power transfer between the coils. The shape and installation position of the ferrite are not particularly limited as long as power transmission can be made more efficient. For example, as shown in FIG. 1, a disc-shaped ferrite 1 can be placed at the center of the extracorporeal coil 2 and the intracorporeal coil 3 and on the side of the extracorporeal coil 2 opposite to the skin.
- the waveform shaping circuit may be any circuit that can shape an input sine wave or the like into a pulse wave (especially a square wave).
- the electrode may be any electrode that can provide effective electrical stimulation to the stomach.
- an electrode for cardiac pacing can be used.
- a sine-wave current flows from the oscillator 4 to the extracorporeal coil 2
- a sine-wave current is generated in the internal coil 3 by electromagnetic induction between the coils.
- This sine wave current is converted into a pulse current by the waveform shaping circuit 5, and this pulse current gives an electric stimulus to the stomach 7 via the electrode 6.
- the gastric stimulator of the present invention can be used for treating diseases such as gastroparesis.
- the body coil, waveform shaping circuit, and gastric stimulation electrodes Prior to treatment, are implanted in the body in advance. There are no particular restrictions on the site in which the internal coil and the waveform shaping circuit are to be implanted.
- the gastric stimulation electrode is placed in contact with the stomach wall, and is usually placed on the anterior wall of the upper stomach of the stomach. The distance between the electrodes is preferably about 5 to 10 nmi.
- the treatment is performed by applying a sinusoidal current from an oscillator to bring the extracorporeal coil closer to the implanted part of the patient's internal coil.
- the frequency and amplitude of the sinusoidal current flowing from the oscillator may be determined as appropriate so as to provide effective electrical stimulation (long pulse stimulation or short pulse stimulation) to the stomach.
- the frequency is 0.03 to 0.06 Hz and the amplitude is 4 to 6 mA.
- the frequency is 0.12 to 0.24 Hz and the amplitude is 2 to 4 mA.
- the gastric stimulator of the present invention is suitable for applying long pulse stimulation.
- long pulse stimulation is effective for patients with gastroparesis in which the vagus nerve has been cut. Therefore, the gastric stimulator of the present invention is particularly useful as a therapeutic device for gastroparesis patients whose vagus nerve is severed.
- Figure 1 shows the location of the ferrite with respect to the extracorporeal coil and the internal coil. It is.
- FIG. 2 is a diagram schematically showing a gastric stimulator of the present invention.
- FIG. 3 is a layout diagram of electrodes and various devices used in the example. .
- FIG. 4 is a block diagram of a transcutaneous power transmission system. BEST MODE FOR CARRYING OUT THE INVENTION
- Electrode implantation was performed under general anesthesia after fasting for at least 12 hours.
- Anesthetic was administered intravenously at 20 mg / kg of chemiamine at the time of introduction, tracheal intubation was performed, and respiratory management was performed with a ventilator.
- Anesthesia was maintained with about 2% of the inhaled anesthetic isoflurane.
- An abdominal midline incision was performed, and four pairs of 28-gauge stainless steel cardiac pacing wires (A & E Medical Farmingdale) were implanted from the serosal side of the stomach into the proper muscle layer on the greater anterior wall curvature.
- the distance between the paired electrodes is lcm, and the four pairs of electrodes arranged in the order of chl (61), ch2 (62), ch3 (63), and ch4 (64) from the mouth side are at 4cm intervals.
- the anal electrode was 2 cm from the pylorus.
- a force sensor, Force Transducer-1 8 (Star Medical) was applied to the serosa on the anterior wall 4 cm from the pylorus to measure the contractile force.
- Teff Ronco derived one tee one ring has been a lead is abdominal out from the upper ventral abdomen was derived from the right breast of the body further through the subcutaneous (FIG. 3) 0
- vagus nerve transection operation was performed. Anesthesia was performed in the same manner as in the first operation, and the abdomen was opened through a midline incision in the upper abdomen. ).
- the experiment was started on and after 7 days after the operation was judged to have completely recovered from the operation.
- the same individuals were tested at intervals of at least two days. After fasting for 12 hours or more, they were ingested 400 g, 340 Kcal dodduff (wet food containing beef, vegetables, etc.), and measurement was started 30 minutes later.
- the first 30 minutes consist of baseline gastric EMG activity and After that, the control group was subjected to electrical stimulation for 30 minutes without stimulation and the gastric electrical stimulation group for 30 minutes without stimulation. All experiments were performed consciously.
- the electrode closest to the mouth was connected to a stimulator 10 (DPS-1200D, Dia Medical System), and electrical stimulation was performed using a square wave (Fig. 3).
- the stimulation conditions were as follows: for long pulse stimulation, the frequency was 1.1 times the intrinsic gastric slow wave frequency, the pulse width was 550 ms, and the pulse amplitude was 4 mA.
- the frequency was 20 cpm, the pulse width was 0.3 ms, and the pulse amplitude was 2 mA.
- Gastric myoelectric activity and contractile force were measured before and after transection of the vagus nerve under three conditions: control, long pulse stimulation, and short pulse stimulation. In addition to these, gastric myoelectric activity and contractile force were measured under conditions of long pulse stimulation after vagus nerve transection using a device using a percutaneous power transmission system.
- the recording of gastric myoelectric activity was performed by connecting a recording electrode led out of the body to a multi-channel recorder 11 (Acknowledge, Biopac Systems) (Fig. 3).
- the recorded waveform was displayed on the monitor of a personal computer 12 and simultaneously saved on a hard disk (Fig. 3).
- the cut-off frequency was set to 0.05 Hz and the high cut-off frequency was set to 35 Hz.
- a 1 Hz low-pass filter was applied by software and resampled to 4 Hz.
- Gastric myoelectric activity was analyzed by running and spectrum analysis using the following two parameters.
- Stomach slow waves in normal dogs have been reported to be 3.5-7 cpm. Recording of gastric myoelectric activity One night is separated every minute, and if the value of the frequency (dominant frequency) at which the intensity of each running spectrum is the maximum is in the range of 3.5 to 7 cpm, ⁇ normal slow wave '' The ratio of the normal slow wave during the observation time was defined as the normal slow wave rate.
- the normal slow wave rate is a parameter that reflects the regularity of gastric myoelectric activity.
- the slow waves of the two channels were assumed to be “conjugated”, and the proportion conjugate during the observation period was defined as the slow wave conjugation rate.
- the slow wave conjugation ratio is a parameter that reflects the transmission of slow waves from the oral side to the anal side.
- the coil used for the transcutaneous power transmission system is a multi-layer coil of O.lmm diameter copper wire, and a magnetic material (ferrite) of Mn-Cu-Zn is used outside the contact surface. I have.
- the external dimensions of the extracorporeal coil and the internal coil are 42mm long, 32inm wide and 6mm thick.
- FIG. 4 A block diagram of the transcutaneous power transfer system is shown in Figure 4.
- a stimulating waveform of long pulse stimulation from the current generated from oscillator 13 (NF Corporation's circuit design block, WAVE FACTORY 1946 MULTIFUNCTION SYNTHESIZER)
- a 100 kHz The sine wave burst waveform was input to the extracorporeal coil 2, and the induced voltage of the extracorporeal coil 2 was passed through the waveform shaping circuit 5 to shape the sine wave into a square wave.
- the wiring of the electrode 6 was once taken out of the body, put back the shunt resistor 14 and returned to the body again.
- the voltage was adjusted with an oscillator so that the generated current had a frequency of IGFX 1.1, a pulse width of 550 ms, and a measurement current of 4 mA.
- the generated stimulus waveform was observed in real time with an oscilloscope.
- the contraction force before the transection of the vagus nerve is 0.93 soil 0.20 in the control group, whereas the long pulse stimulation group is 0.79 ⁇ 0.23 in the control group, and the short pulse stimulation group is 1.45 soil 0.62 in the control group.
- the change rate of the normal slow wave rate was 0.92 ⁇ 0.18 for the control group, 1.24 ⁇ 0.78 for the long pulse stimulation group, 0.95 ⁇ 0.20 for the short pulse stimulation group, and the change rate of the slow wave conjugation rate was 0.92 for the control group and 0.23 for long pulse stimulation.
- the rate of change of the area under the curve was 1.00 ⁇ 0.22 in the control group, 1.23 ⁇ 0.22 in the long pulse stimulation group, and 0.96 ⁇ 0.09 in the short pulse stimulation group, and the long pulse stimulation tended to increase.
- positive The rate of change in the normal slow wave rate was 0.96 ⁇ 0.07 in the control group, 1.31 ⁇ 0.39 in the long pulse stimulation group, 0.93 ⁇ 0.10 in the short pulse stimulation group, and significantly increased in the long pulse stimulation group.
- gastric electrical stimulation using a conventional stimulator and gastric electrical stimulation using a percutaneous power transmission system were compared with those in a control group.
- the ANOVA showed no significant change in the rate of change of the area under the curve between the control group, 1.00 ⁇ 0.22, the conventional group, 1.23 ⁇ 0.22, and the transcutaneous power transmission system group, 1.11 ⁇ 0.47.
- the rate of change of the normal slow wave rate was 0.96 ⁇ 0.07 for the control group, 1.31 ⁇ 0.39 for the conventional device group, and 1.39 ⁇ 0.40 for the transcutaneous power transmission system device group.
- the gastric electric stimulator of the present invention is useful for treatment of gastroparesis and the like.
- long pulse stimulation is effective for treating gastroparesis patients whose vagus nerve is severed, but the device of the present invention can continue to apply this long pulse stimulation for a long time. Therefore, the device of the present invention is particularly useful as a treatment device for gastroparesis patients whose vagus nerve has been cut.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003289098A AU2003289098A1 (en) | 2002-12-25 | 2003-12-16 | Device for electrically stimulating stomach |
EP03778941A EP1576984A4 (en) | 2002-12-25 | 2003-12-16 | Device for electrically stimulating stomach |
US10/540,386 US7363084B2 (en) | 2002-12-25 | 2003-12-16 | Device for electrically stimulating stomach |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002373975A JP2004201901A (en) | 2002-12-25 | 2002-12-25 | Stomach electrostimulator |
JP2002-373975 | 2002-12-25 |
Publications (1)
Publication Number | Publication Date |
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WO2004058349A1 true WO2004058349A1 (en) | 2004-07-15 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2003/016065 WO2004058349A1 (en) | 2002-12-25 | 2003-12-16 | Device for electrically stimulating stomach |
Country Status (5)
Country | Link |
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US (1) | US7363084B2 (en) |
EP (1) | EP1576984A4 (en) |
JP (1) | JP2004201901A (en) |
AU (1) | AU2003289098A1 (en) |
WO (1) | WO2004058349A1 (en) |
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- 2003-12-16 US US10/540,386 patent/US7363084B2/en not_active Expired - Fee Related
- 2003-12-16 EP EP03778941A patent/EP1576984A4/en not_active Withdrawn
- 2003-12-16 AU AU2003289098A patent/AU2003289098A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
US7363084B2 (en) | 2008-04-22 |
AU2003289098A1 (en) | 2004-07-22 |
US20060129200A1 (en) | 2006-06-15 |
JP2004201901A (en) | 2004-07-22 |
EP1576984A1 (en) | 2005-09-21 |
EP1576984A4 (en) | 2007-05-30 |
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