WO2004069983A3 - Microreactor architecture and methods - Google Patents

Microreactor architecture and methods Download PDF

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Publication number
WO2004069983A3
WO2004069983A3 PCT/US2003/025943 US0325943W WO2004069983A3 WO 2004069983 A3 WO2004069983 A3 WO 2004069983A3 US 0325943 W US0325943 W US 0325943W WO 2004069983 A3 WO2004069983 A3 WO 2004069983A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
reaction
chip
chips
present
Prior art date
Application number
PCT/US2003/025943
Other languages
French (fr)
Other versions
WO2004069983A9 (en
WO2004069983A2 (en
Inventor
Seth T Rodgers
Peter A Russo
Howard B Schreyer
Sean J Leblanc
Andrey J Zarur
Xinyu Li
Original Assignee
Bioprocessors Corp
Seth T Rodgers
Peter A Russo
Howard B Schreyer
Sean J Leblanc
Andrey J Zarur
Xinyu Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/457,049 external-priority patent/US20040058437A1/en
Priority claimed from US10/457,015 external-priority patent/US20040058407A1/en
Application filed by Bioprocessors Corp, Seth T Rodgers, Peter A Russo, Howard B Schreyer, Sean J Leblanc, Andrey J Zarur, Xinyu Li filed Critical Bioprocessors Corp
Priority to CA002496017A priority Critical patent/CA2496017A1/en
Priority to JP2005515706A priority patent/JP2006521786A/en
Priority to EP03815293A priority patent/EP1567637A2/en
Priority to AU2003303303A priority patent/AU2003303303A1/en
Priority to US10/664,067 priority patent/US20050032204A1/en
Publication of WO2004069983A2 publication Critical patent/WO2004069983A2/en
Publication of WO2004069983A9 publication Critical patent/WO2004069983A9/en
Publication of WO2004069983A3 publication Critical patent/WO2004069983A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH

Abstract

The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.
PCT/US2003/025943 2001-04-10 2003-08-19 Microreactor architecture and methods WO2004069983A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002496017A CA2496017A1 (en) 2002-08-19 2003-08-19 Microreactor architecture and methods
JP2005515706A JP2006521786A (en) 2002-08-19 2003-08-19 Microreactor structure and method
EP03815293A EP1567637A2 (en) 2002-08-19 2003-08-19 Microreactor architecture and methods
AU2003303303A AU2003303303A1 (en) 2002-08-19 2003-08-19 Microreactor architecture and methods
US10/664,067 US20050032204A1 (en) 2001-04-10 2003-09-16 Microreactor architecture and methods

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US22356202A 2002-08-19 2002-08-19
US10/223,562 2002-08-19
US40927302P 2002-09-09 2002-09-09
US60/409,273 2002-09-09
US45613303A 2003-06-05 2003-06-05
US45704803A 2003-06-05 2003-06-05
US45693403A 2003-06-05 2003-06-05
US10/457,049 US20040058437A1 (en) 2001-04-10 2003-06-05 Materials and reactor systems having humidity and gas control
US10/457,049 2003-06-05
US10/457,015 2003-06-05
US10/457,015 US20040058407A1 (en) 2001-04-10 2003-06-05 Reactor systems having a light-interacting component
US10/456,934 2003-06-05
US10/457,048 2003-06-05
US10/456,133 2003-06-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/664,067 Continuation US20050032204A1 (en) 2001-04-10 2003-09-16 Microreactor architecture and methods

Publications (3)

Publication Number Publication Date
WO2004069983A2 WO2004069983A2 (en) 2004-08-19
WO2004069983A9 WO2004069983A9 (en) 2005-02-03
WO2004069983A3 true WO2004069983A3 (en) 2005-07-14

Family

ID=31892403

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2003/025907 WO2004016729A2 (en) 2002-04-10 2003-08-19 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS
PCT/US2003/025956 WO2004016727A1 (en) 2001-04-10 2003-08-19 Determination and/or control of reactor environmental conditions
PCT/US2003/025943 WO2004069983A2 (en) 2001-04-10 2003-08-19 Microreactor architecture and methods

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2003/025907 WO2004016729A2 (en) 2002-04-10 2003-08-19 SYSTEMS AND METHODS FOR CONTROL OF pH AND OTHER REACTOR ENVIRONMENTAL CONDITIONS
PCT/US2003/025956 WO2004016727A1 (en) 2001-04-10 2003-08-19 Determination and/or control of reactor environmental conditions

Country Status (5)

Country Link
EP (2) EP1567637A2 (en)
JP (2) JP2005536233A (en)
AU (3) AU2003303303A1 (en)
CA (2) CA2495617A1 (en)
WO (3) WO2004016729A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
GB0210809D0 (en) * 2002-05-11 2002-06-19 Univ Durham Reactor
JP4664646B2 (en) * 2004-10-20 2011-04-06 一般社団法人オンチップ・セロミクス・コンソーシアム Cell culture microchamber and cell structure construction method
EP1815244A4 (en) * 2004-11-11 2009-07-22 Agency Science Tech & Res Cell culture device
ZA200704952B (en) 2004-12-03 2008-11-26 Cytonome Inc Unitary cartridge for particle processing
DE102005004075B4 (en) * 2005-01-28 2008-04-03 Umicore Ag & Co. Kg Ceramic microreactor
EP2537657A3 (en) 2005-08-09 2016-05-04 The University of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
DE102006030068A1 (en) 2006-06-28 2008-01-03 M2P-Labs Gmbh Apparatus and method for the supply and removal of fluids in shaken microreactors arrays
CN103203256B (en) 2006-07-19 2015-09-23 博纳基因技术有限公司 Nanometer mouth apparatus array: their preparation and the application in large analysis of molecules
US7811359B2 (en) 2007-01-18 2010-10-12 General Electric Company Composite membrane for separation of carbon dioxide
JP2008194029A (en) * 2007-01-19 2008-08-28 Tosoh Corp Cell fusion apparatus and cell fusion method using the same
CN103305402A (en) 2007-03-28 2013-09-18 博纳基因技术有限公司 Method of macromolecular analysis using nanochannel arrays
JP4963437B2 (en) * 2007-03-30 2012-06-27 京セラ株式会社 Flow path body, wiring board, flow path forming wiring board, flow path forming method, flow path body manufacturing method, and flow path body kit
JP2011500018A (en) * 2007-10-11 2011-01-06 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ Method for forming a cell structure using a temporary linker in a cage
CN102057034A (en) * 2008-06-13 2011-05-11 福斯分析股份公司 Process control of biotechnological processes
CA3062190C (en) 2008-06-30 2023-03-28 Bionano Genomics, Inc. Methods and devices for single-molecule whole genome analysis
CN104372080B (en) 2008-11-18 2018-03-30 博纳基因技术有限公司 polynucleotide mapping and sequencing
DE102014214077A1 (en) * 2014-07-18 2016-01-21 Hamilton Bonaduz Ag Laboratory containers, in particular cell culture containers, with a gas compensation line extending into the container volume
US10626365B2 (en) 2015-01-26 2020-04-21 Ube Industries, Ltd. Long-term cell-cultivation using polyimide porous membrane and cell-cryopreservation method using polyimide porous membrane
NL2020612B1 (en) 2017-12-22 2019-07-02 Illumina Inc Light detection devices with protective liner and methods of manufacturing same
CN109799012B (en) * 2019-01-23 2021-01-22 河南工程学院 Cellulose-based sandwich-like structure pressure sensor and preparation method thereof
WO2023057602A1 (en) * 2021-10-08 2023-04-13 Philip Morris Products S.A. Detection of bioactive agents in a surrounding medium

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6245295B1 (en) * 1995-05-31 2001-06-12 Bio Merieux, Inc. Sample testing apparatus with high oxygen permeable tape providing barrier for closed reaction chamber
WO2001092462A1 (en) * 1999-05-28 2001-12-06 Ashby Scientific Ltd. Culture chamber
US20020055166A1 (en) * 2000-10-02 2002-05-09 Cannon Thomas F. Automated bioculture and bioculture experiments system
EP1221617A2 (en) * 2000-12-29 2002-07-10 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Biological Assays
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
EP1226871A2 (en) * 2001-01-24 2002-07-31 Ebara Corporation Reactive probe chip and reactive detection sytem
WO2002100542A1 (en) * 2001-06-08 2002-12-19 Centre National De La Recherche Scientifique Method of manufacturing a microfluidic structure, in particular a biochip, and structure obtained by said method_________________

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19753598C1 (en) * 1997-12-03 1999-07-01 Micronas Intermetall Gmbh Device for measuring physiological parameters
JP2899701B1 (en) * 1998-06-19 1999-06-02 工業技術院長 Transmission switch type carbon film
JP2001157879A (en) * 1999-08-31 2001-06-12 Tadahiro Omi METHOD AND APPARATUS FOR CONTROLLING pH OF AQUEOUS SOLUTION
JP3200631B2 (en) * 1999-09-08 2001-08-20 北陸先端科学技術大学院大学長 Biosensor for measuring effects on cell metabolic activity
JP2001129557A (en) * 1999-11-08 2001-05-15 Japan Organo Co Ltd Water treatment method
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
US6673532B2 (en) * 2000-08-14 2004-01-06 University Of Maryland, Baltimore County Bioreactor and bioprocessing technique

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US6245295B1 (en) * 1995-05-31 2001-06-12 Bio Merieux, Inc. Sample testing apparatus with high oxygen permeable tape providing barrier for closed reaction chamber
WO2001092462A1 (en) * 1999-05-28 2001-12-06 Ashby Scientific Ltd. Culture chamber
US20020055166A1 (en) * 2000-10-02 2002-05-09 Cannon Thomas F. Automated bioculture and bioculture experiments system
EP1221617A2 (en) * 2000-12-29 2002-07-10 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Biological Assays
EP1226871A2 (en) * 2001-01-24 2002-07-31 Ebara Corporation Reactive probe chip and reactive detection sytem
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
WO2002100542A1 (en) * 2001-06-08 2002-12-19 Centre National De La Recherche Scientifique Method of manufacturing a microfluidic structure, in particular a biochip, and structure obtained by said method_________________

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1567637A2 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays

Also Published As

Publication number Publication date
WO2004016729A2 (en) 2004-02-26
EP1530626A1 (en) 2005-05-18
WO2004016729A3 (en) 2005-06-30
JP2006521786A (en) 2006-09-28
AU2003272223A1 (en) 2004-03-03
AU2003303303A1 (en) 2004-08-30
WO2004069983A9 (en) 2005-02-03
CA2496017A1 (en) 2004-08-19
AU2003265491A8 (en) 2004-03-03
WO2004069983A2 (en) 2004-08-19
JP2005536233A (en) 2005-12-02
EP1567637A2 (en) 2005-08-31
WO2004016727B1 (en) 2004-07-08
AU2003265491A1 (en) 2004-03-03
WO2004016727A9 (en) 2004-05-27
CA2495617A1 (en) 2004-02-26
WO2004016727A1 (en) 2004-02-26

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