WO2004089235A3 - Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue - Google Patents

Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue Download PDF

Info

Publication number
WO2004089235A3
WO2004089235A3 PCT/US2004/010182 US2004010182W WO2004089235A3 WO 2004089235 A3 WO2004089235 A3 WO 2004089235A3 US 2004010182 W US2004010182 W US 2004010182W WO 2004089235 A3 WO2004089235 A3 WO 2004089235A3
Authority
WO
WIPO (PCT)
Prior art keywords
organ
cassette
methods
tissue
transport
Prior art date
Application number
PCT/US2004/010182
Other languages
French (fr)
Other versions
WO2004089235A2 (en
Inventor
David Walter Wright
John Brassil
Douglas Schein
Jeffrey C Garland
Lee Williams Travis
Original Assignee
Organ Recovery Systems Inc
David Walter Wright
John Brassil
Douglas Schein
Jeffrey C Garland
Lee Williams Travis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organ Recovery Systems Inc, David Walter Wright, John Brassil, Douglas Schein, Jeffrey C Garland, Lee Williams Travis filed Critical Organ Recovery Systems Inc
Priority to ES04758782T priority Critical patent/ES2885752T3/en
Priority to PL04758782T priority patent/PL1613153T3/en
Priority to EP04758782.9A priority patent/EP1613153B1/en
Priority to CA2521324A priority patent/CA2521324C/en
Publication of WO2004089235A2 publication Critical patent/WO2004089235A2/en
Publication of WO2004089235A3 publication Critical patent/WO2004089235A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A01N1/0273—Transport containers
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers

Abstract

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied. The apparatus and methods further include the cassette with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces. The apparatus and methods further include a tube frame removably connected to the cassette and configured to hold a plurality of tubes in a position to be connected to tubes in the portable housing.
PCT/US2004/010182 2003-04-04 2004-04-02 Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue WO2004089235A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES04758782T ES2885752T3 (en) 2003-04-04 2004-04-02 Methods and apparatus for perfusion, diagnosis, storage and / or transport of an organ or tissue
PL04758782T PL1613153T3 (en) 2003-04-04 2004-04-02 Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue
EP04758782.9A EP1613153B1 (en) 2003-04-04 2004-04-02 Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue
CA2521324A CA2521324C (en) 2003-04-04 2004-04-02 Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45998603P 2003-04-04 2003-04-04
US60/459,986 2003-04-04

Publications (2)

Publication Number Publication Date
WO2004089235A2 WO2004089235A2 (en) 2004-10-21
WO2004089235A3 true WO2004089235A3 (en) 2005-06-23

Family

ID=33159718

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010182 WO2004089235A2 (en) 2003-04-04 2004-04-02 Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue

Country Status (6)

Country Link
US (5) US7691622B2 (en)
EP (1) EP1613153B1 (en)
CA (3) CA2521324C (en)
ES (1) ES2885752T3 (en)
PL (1) PL1613153T3 (en)
WO (1) WO2004089235A2 (en)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US6673594B1 (en) * 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
WO2001053154A1 (en) * 2000-01-20 2001-07-26 Bioaccess, Inc. A method and apparatus for introducing a non-sterile component into a sterile device
US6677150B2 (en) * 2001-09-14 2004-01-13 Organ Transport Systems, Inc. Organ preservation apparatus and methods
US20040170950A1 (en) * 2002-09-12 2004-09-02 Prien Samuel D. Organ preservation apparatus and methods
US7691622B2 (en) * 2003-04-04 2010-04-06 Lifeline Scientific, Inc. Method and apparatus for transferring heat to or from an organ or tissue container
US20050153271A1 (en) * 2004-01-13 2005-07-14 Wenrich Marshall S. Organ preservation apparatus and methods
US7504201B2 (en) 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
US7651835B2 (en) 2004-10-07 2010-01-26 Transmedics, Inc. Method of timing pulsatile flow of normothermic perfusate to the heart
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US8147408B2 (en) * 2005-08-31 2012-04-03 Sonosite, Inc. Medical device guide locator
DK1942726T3 (en) 2006-04-19 2017-04-10 Transmedics Inc METHODS FOR EX VIVO ORGANIC CARE
US20080145919A1 (en) * 2006-12-18 2008-06-19 Franklin Thomas D Portable organ and tissue preservation apparatus, kit and methods
WO2008108996A1 (en) 2007-03-01 2008-09-12 Lifeline Scientific, Inc. Perfusion regulation
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
EP2203046B1 (en) * 2007-09-28 2015-05-27 Organ Assist B.V. Organ transport container system
US10750738B2 (en) 2008-01-31 2020-08-25 Transmedics, Inc. Systems and methods for ex vivo lung care
DE502008002609D1 (en) * 2008-03-06 2011-03-31 Eutecma Gmbh Cooling element with supercooling protection
WO2009132018A1 (en) * 2008-04-22 2009-10-29 The Board Of Regents Of The University Of Texas System Fluidics-based pulsatile perfusion organ preservation device
ES2750256T3 (en) * 2008-05-06 2020-03-25 Xvivo Perfusion Ab Apparatus to house an organ during its evaluation and conservation
CN102124333B (en) * 2008-06-17 2014-06-04 多伦多大学管理委员会 Device for investigation of a flow conduit
US9284523B2 (en) * 2008-10-27 2016-03-15 Terumo Bct, Inc. Premounted fluid conveyance assembly for cell expansion system and method of use associated therewith
WO2011002926A2 (en) 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US9084416B2 (en) 2009-09-25 2015-07-21 Vivoline Medical Ab Container and supporting structure for housing an organ
EP2480069A1 (en) * 2009-09-25 2012-08-01 Board of Regents, The University of Texas System Fluidics based pulsatile perfusion preservation device and method
WO2011126650A1 (en) * 2010-04-09 2011-10-13 Caridianbct, Inc. Air removal chamber for a cell expansion system and method of use associated therewith
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US9119392B2 (en) * 2010-11-09 2015-09-01 Biomedinnovations, Llc Articulating organ support
WO2012078968A2 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
US20120178076A1 (en) * 2011-01-07 2012-07-12 Hiroyuki Fujita Magnetic resonance and non-magnetic resonance analysis
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
CA2830225C (en) 2011-03-15 2020-03-24 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
JP6029650B2 (en) 2011-04-14 2016-11-24 トランスメディクス，インコーポレイテッド Organ protection solution for mechanical perfusion in ex-vivo of donor lung
US9955682B2 (en) * 2011-04-29 2018-05-01 Lifeline Scientific, Inc. Portable organ transportation system
US9642625B2 (en) 2011-04-29 2017-05-09 Lifeline Scientific, Inc. Cannula for a donor organ with or without an aortic cuff or patch
US9022978B2 (en) 2011-04-29 2015-05-05 Lifeline Scientific, Inc. Universal sealring cannula
US8828034B2 (en) 2011-04-29 2014-09-09 Lifeline Scientific, Inc. Cannula
US20150253232A1 (en) * 2011-05-02 2015-09-10 The Governing Council Of The University Of Toronto Device for investigation of a flow conduit
EP2750499B1 (en) 2011-09-02 2016-07-20 Organ Assist B.V. Apparatus, system and method for conditioning and preserving an organ from a donor
EP2775829B1 (en) * 2011-11-10 2018-07-11 Organox Limited Organ perfusion systems
GB201119420D0 (en) 2011-11-10 2011-12-21 Organox Ltd Oxygen supply for organ perfusion systems
CA2855337C (en) 2011-11-10 2020-08-18 Organox Limited Organ perfusion systems
US10258032B2 (en) * 2012-01-11 2019-04-16 Lifeline Scientific, Inc. Transportation bag for use with an organ transporter
US8894647B2 (en) 2012-01-13 2014-11-25 Covidien Lp System and method for performing surgical procedures with a reusable instrument module
US9636091B2 (en) 2012-01-13 2017-05-02 Covidien Lp Hand-held electromechanical surgical system
US9241757B2 (en) 2012-01-13 2016-01-26 Covidien Lp System and method for performing surgical procedures with a reusable instrument module
EP4091446A1 (en) 2012-01-17 2022-11-23 Tevosol, Inc. Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting
US9115936B2 (en) * 2012-02-15 2015-08-25 Wave Power Technology, Inc. Cooling apparatus and method using a vacuum pump
US9402389B2 (en) 2012-07-10 2016-08-02 Lifeline Scientific, Inc. Organ transport apparatus with sample compartments
US9357766B2 (en) 2012-07-10 2016-06-07 Lifeline Scientific, Inc. Organ transport apparatus with a document compartment and a tamper evident seal
US9357767B2 (en) 2012-07-10 2016-06-07 Lifeline Scientific, Inc. Organ transporter
US11439143B2 (en) 2012-07-10 2022-09-13 Lifeline Scientific, Inc. Temperature sensing in organ preservation apparatus
US10602740B2 (en) * 2012-07-10 2020-03-31 Lifeline Scientific, Inc. Organ perfusion apparatus with downstream flow control
US20140017666A1 (en) 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Filtration in organ perfusion apparatus
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
US10433538B2 (en) 2012-10-12 2019-10-08 University of Pittsburgh—of the Commonwealth System of Higher Education Compositions and methods for organ preservation
WO2015138832A1 (en) 2014-03-13 2015-09-17 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
CA3164819A1 (en) 2014-03-26 2015-10-01 Tevosol, Inc. Apparatus for maintenance of harvested hearts for transplanting
CA2950759C (en) 2014-06-02 2023-02-21 Transmedics, Inc. Ex vivo organ care system
USD765874S1 (en) 2014-10-10 2016-09-06 Paragonix Technologies, Inc. Transporter for a tissue transport system
CA3155169A1 (en) * 2014-12-12 2016-06-16 Tevosol, Inc. Apparatus and method for organ perfusion
WO2017044465A1 (en) 2015-09-09 2017-03-16 Transmedics, Inc Aortic cannula for ex vivo organ care system
WO2017070639A1 (en) * 2015-10-23 2017-04-27 Tatom Patrick Alan Device for cooling substances
US10091986B2 (en) 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
US20190183114A1 (en) * 2016-08-05 2019-06-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for the preservationof organs
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
US10602741B2 (en) * 2016-11-28 2020-03-31 Universidad Del Valle Organ-chimerization maintenance apparatus and method of use
US11129379B2 (en) 2017-04-28 2021-09-28 Lifeline Scientific, Inc. Organ transporter with supplemental oxygenation system
US11285471B2 (en) * 2017-05-30 2022-03-29 Nextern Innovation, Llc Portable controlled micro-environment device for modular bio-processing
CA3066625A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
CN107897169B (en) * 2017-11-03 2023-09-15 四川大学华西医院 Isolated organ oxygenation perfusion device
EP4017262A4 (en) * 2019-08-23 2023-09-06 Paragonix Technologies Inc. Pressurized system for tissue transport and preservation
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
EP3977854A1 (en) * 2020-10-02 2022-04-06 Aferetica S.r.l. Thermoregulation system for an ex vivo organ perfusion system and corresponding ex vivo organ perfusion system
US20230092486A1 (en) 2021-09-23 2023-03-23 Lifeline Scientific, Inc. Low fluid level detection device

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545225A (en) * 1968-08-16 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining whole organs in a viable state
US3772153A (en) * 1969-04-02 1973-11-13 Air Liquide Apparatus for the preservation of animal or human organs in living condition
US4460102A (en) * 1982-09-23 1984-07-17 Barringer Albert J Sealed container
FR2583386A1 (en) * 1985-06-12 1986-12-19 Sartec Service Ind Valve for package and package comprising such a valve.
WO1996039027A1 (en) * 1995-06-05 1996-12-12 Cytotherapeutics, Inc. Apparatus and method for storage and transportation of bioartificial organs
WO2002018210A1 (en) * 2000-08-28 2002-03-07 Automated Plastic Systems Pty Ltd. Medical transport container
WO2002026034A2 (en) * 2000-08-25 2002-04-04 Organ Recovery Systems Inc. Apparatus and method for maintaining and/or restoring viability of organs

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1682344A (en) * 1928-08-28 lesieur
US1369367A (en) * 1920-01-05 1921-02-22 Henry M Whitney Cooling-container
US1916658A (en) * 1931-10-09 1933-07-04 Louis R Davidson Pneumothorax apparatus
US3406531A (en) 1964-08-25 1968-10-22 Emil S. Swenson Apparatus for maintaining organs in a completely viable state
US3545221A (en) 1967-05-22 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining organs in vitro in a completely viable state
FR1577356A (en) * 1968-04-04 1969-08-08
SE323475B (en) 1968-11-26 1970-05-04 Aga Ab
US3632473A (en) * 1969-04-21 1972-01-04 Univ California Method and apparatus for preserving human organs extracorporeally
US3892628A (en) 1969-10-06 1975-07-01 Baxter Laboratories Inc Preservation of organs
BE755423A (en) * 1969-10-06 1971-02-01 Baxter Laboratories Inc PROCESS AND APPARATUS FOR ORGAN PRESERVATION
US3660241A (en) * 1970-01-12 1972-05-02 Baxter Laboratories Inc Container for organ perfusion or the like
US3639084A (en) 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
US3810367A (en) 1970-07-16 1974-05-14 W Peterson Container for cooling, storage, and shipping of human organ for transplant
US3712583A (en) 1971-01-25 1973-01-23 Ametek Inc Valved for lines carrying extreme temperature fluids
US3753865A (en) 1971-03-12 1973-08-21 Univ California Method and apparatus for preserving human organs extracorporeally
US3713302A (en) * 1971-05-03 1973-01-30 Lek Trol Inc Personal insulin cooler
US3935065A (en) * 1971-09-02 1976-01-27 Roland Karl Doerig Procedure for conservation of living organs and apparatus for the execution of this procedure
DE2241698C2 (en) * 1971-09-02 1982-08-26 Roland Dr.med. Zürich Doerig Process for organ preservation and device for carrying out this process
US3777507A (en) 1971-11-24 1973-12-11 Waters Instr Inc Renal preservation system
US3881990A (en) 1971-11-24 1975-05-06 Waters Instr Inc Method of transporting and storing organs while retaining the organs in a viable condition
FR2169488A5 (en) * 1972-01-27 1973-09-07 Air Liquide
US3843455A (en) 1972-09-13 1974-10-22 M Bier Apparatus and technique for preservation of isolated organs through perfusion
US3877843A (en) * 1973-05-21 1975-04-15 Baxter Laboratories Inc Pulsatile pumping system
JPS5331209B2 (en) * 1973-10-05 1978-09-01
US3995444A (en) 1974-11-08 1976-12-07 American Hospital Supply Corporation Organ perfusion system
US4186565A (en) * 1978-05-19 1980-02-05 Henry Ford Hospital Perfusion system for organ preservation
US4231354A (en) 1978-07-14 1980-11-04 Howmedica, Incorporated Pulsatile blood pumping apparatus and method
US4243883A (en) 1979-01-19 1981-01-06 Midwest Cardiovascular Institute Foundation Blood hematocrit monitoring system
US4242883A (en) * 1979-04-02 1981-01-06 Henry Ford Hospital Liver preservation
US4445500A (en) 1982-03-03 1984-05-01 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4657532A (en) * 1985-07-19 1987-04-14 Thomas Jefferson University Intra-peritoneal perfusion of oxygenated fluorocarbon
US4393863A (en) * 1980-04-14 1983-07-19 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4378797A (en) * 1980-04-14 1983-04-05 Thomas Jefferson University Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US5085630A (en) * 1980-04-14 1992-02-04 Thomas Jefferson University Oxygenated fluorocarbon nutrient solution
US4717548A (en) * 1980-06-09 1988-01-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analytically controlled blood perfusion system
US4629686A (en) 1982-02-19 1986-12-16 Endotronics, Inc. Apparatus for delivering a controlled dosage of a chemical substance
US4451251A (en) 1982-03-03 1984-05-29 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
DE3366419D1 (en) * 1982-06-04 1986-10-30 Hoxan Kk Method of preserving organ and apparatus for preserving the same
US4473637A (en) * 1982-11-10 1984-09-25 Guibert, Colman & Associates System for processing an organ preparatory to transplant
US4559298A (en) 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US4474016A (en) * 1983-03-04 1984-10-02 Baxter Travenol Laboratories, Inc. Sterile cooling system
US4618586A (en) * 1983-04-08 1986-10-21 Endotronics, Inc. Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber
US4837390A (en) * 1983-05-11 1989-06-06 Keyes Offshore, Inc. Hyperbaric organ preservation apparatus and method for preserving living organs
US4462215A (en) 1983-05-31 1984-07-31 Hoxan Corporation Method of preserving organ and apparatus for preserving the same
US4471629A (en) * 1983-05-31 1984-09-18 Mount Carmel Research And Education Corporation Method of freezing and transplant of kidneys and apparatus
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4530816A (en) * 1983-06-15 1985-07-23 Hamilton Farm Method and device for cooling, preserving and safely transporting biological material
US4502295A (en) * 1984-02-21 1985-03-05 Mount Carmel Research And Education Corporation Organ hypothermic storage unit
US4596250A (en) * 1984-11-14 1986-06-24 Genetic Laboratories, Inc. Moldable cooling/heating device with directional cooling/heating
US4723974A (en) * 1985-07-26 1988-02-09 Ammerman Stephen W Transporting container for an amputated extremity
US4879283A (en) 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4666425A (en) * 1985-12-17 1987-05-19 The Dis Corporation Device for perfusing an animal head
US4704029A (en) 1985-12-26 1987-11-03 Research Corporation Blood glucose monitor
GB8619437D0 (en) * 1986-08-08 1986-09-17 Bradley L Storage & refrigeration
US4745759A (en) 1986-12-23 1988-05-24 Bauer Dan O Kidney preservation machine
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
US5051352A (en) * 1987-10-07 1991-09-24 The Regents Of The University Of California Apparatus and method of preserving the viability of animal organs
JPH0626138B2 (en) * 1987-11-20 1994-04-06 昭和電工株式会社 Secondary battery
FR2628077B1 (en) * 1988-03-07 1990-08-03 Guilhem Jacques CONTAINER FOR TRANSPORTING GRAFT
EP0337677A3 (en) * 1988-04-11 1990-04-04 Costar Corporation Vent cap
US5130230A (en) 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
AU633280B2 (en) * 1988-10-26 1993-01-28 Michael Kaye A device for transportation of human organs used for transplantation
US5013303A (en) * 1988-11-03 1991-05-07 Yehuda Tamari Constant pressure infusion device
US4951482A (en) * 1988-12-21 1990-08-28 Gilbert Gary L Hypothermic organ transport apparatus
US5110721A (en) 1989-02-10 1992-05-05 The Research Foundation Of State University Of New York Method for hypothermic organ protection during organ retrieval
US5326706A (en) 1989-07-17 1994-07-05 Research Foundation Of State University Of New York Homeostatic organ preservation system
ES2093648T3 (en) * 1989-07-27 1997-01-01 Leonora I Jost BIOLOGICAL SUPPORT SYSTEM, CONTAINER AND PROCEDURE FOR PRESERVING LIVING MAMMALS, EX VIVO.
JPH0653160B2 (en) 1989-08-18 1994-07-20 呉羽化学工業株式会社 Beat generation method and device
US5200176A (en) * 1989-10-06 1993-04-06 Genentech, Inc. Method for protection of ischemic tissues using tumor nerosis factor
US5036097A (en) 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5066578A (en) 1989-12-21 1991-11-19 The Regents Of The University Of California Long-term preservation of organs for transplantation
US5003787A (en) * 1990-01-18 1991-04-02 Savant Instruments Cell preservation system
US5145771A (en) * 1990-04-12 1992-09-08 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
US5047395A (en) 1990-07-17 1991-09-10 Nagase Co., Ltd. Reduction of oxyradical damage in biomedical applications
FR2667297B1 (en) 1990-09-28 1994-05-27 Electrolux Sarl AIR-CONDITIONED MEDICAL CONTAINER.
US5584804A (en) 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5395314A (en) 1990-10-10 1995-03-07 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5827222A (en) * 1990-10-10 1998-10-27 Life Resuscitation Technologies, Inc. Method of treating at least one of brain and associated nervous tissue injury
US5149321A (en) * 1990-10-10 1992-09-22 Klatz Ronald M Brain resuscitation device and method for performing the same
US5308320A (en) * 1990-12-28 1994-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method
US5157930A (en) * 1991-04-22 1992-10-27 Mcghee Samuel C Organ preservation apparatus
US5856081A (en) 1991-07-08 1999-01-05 The American National Red Cross Computer controlled cryoprotectant perfusion apparatus
US5723282A (en) * 1991-07-08 1998-03-03 The American National Red Cross Method of preparing organs for vitrification
US5217860A (en) * 1991-07-08 1993-06-08 The American National Red Cross Method for preserving organs for transplantation by vitrification
US5216032A (en) 1991-09-30 1993-06-01 The University Of North Carolina At Chapel Hill Selective aortic arch perfusion using perfluorochemical and alpha adrenergic agonist to treat cardiac arrest
US5328821A (en) 1991-12-12 1994-07-12 Robyn Fisher Cold and cryo-preservation methods for human tissue slices
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
DE4301524A1 (en) 1993-01-21 1994-07-28 Jostra Medizintechnik Medical unit or device for operating theaters, in particular heart-lung machine
ATE204770T1 (en) * 1993-03-03 2001-09-15 Deka Products Lp CASSETTE FOR PERIOTONEAL DIALYSIS
US5362622A (en) * 1993-03-11 1994-11-08 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation apparatus
US5356771A (en) 1993-03-11 1994-10-18 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation organ preservation apparatus
US5599659A (en) 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
AU6409594A (en) 1993-03-16 1994-10-11 Alliance Pharmaceutical Corporation Preservation solution and method for warm organ preservation
US5462416A (en) * 1993-12-22 1995-10-31 Baxter International Inc. Peristaltic pump tube cassette for blood processing systems
US5437633A (en) 1994-03-30 1995-08-01 The University Of North Carolina At Chapel Hill Selective aortic arch perfusion
AU2595195A (en) 1994-05-20 1995-12-18 Vec Tec, Inc. Method and apparatus monitoring viability of transplantable organs
US5643712A (en) 1994-05-20 1997-07-01 Brasile; Lauren Method for treating and rendering grafts nonthrombogenic and substantially nonimmunogenic using an extracellular matrix coating
US5823986A (en) * 1995-02-08 1998-10-20 Medtronic, Inc. Perfusion system
US5586438A (en) 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
US5730720A (en) 1995-08-18 1998-03-24 Ip Scientific, Inc. Perfusion hyperthermia treatment system and method
US5712084A (en) 1995-09-08 1998-01-27 Research Corporation Technologies, Inc. Donor kidney viability test for improved preservation
US5712583A (en) * 1995-11-13 1998-01-27 International Business Machines Corporation Clock phase alignment using frequency comparison
JPH09167708A (en) * 1995-12-15 1997-06-24 Toko Inc Inverter transformer
US5843024A (en) 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US5965433A (en) 1996-05-29 1999-10-12 Trans D.A.T.A. Service, Inc. Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for pulsatile cycling of oxygenated perfusate
US5716378A (en) * 1996-06-06 1998-02-10 Medtronic, Inc. Heart preservation and transportation apparatus and method employing low rate cardiac pacing for improved removal of catabolites from the myocardium
US5879329A (en) 1997-01-22 1999-03-09 Radiant Medical, Inc. Infusion systems and methods for introducing fluids into the body within a desired temperature range
US5928182A (en) * 1997-07-02 1999-07-27 Johnson & Johnson Professional, Inc. Pediatric programmable hydrocephalus valve
US6953655B1 (en) * 1997-09-23 2005-10-11 The United States Of America As Represented By The Department Of Veterans Affairs Compositions, methods and devices for maintaining an organ
US6100082A (en) * 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ
US6582953B2 (en) * 1999-04-14 2003-06-24 Breonics, Inc. Organ chamber for exsanguinous metabolic support system
US20080027368A1 (en) * 2000-09-27 2008-01-31 Sorin Group Usa, Inc. Disposable cartridge for a blood perfusion system
JP4195287B2 (en) * 2000-10-02 2008-12-10 エフ．キャノン トーマス Automated bioculture and bioculture experimental system
US6677150B2 (en) * 2001-09-14 2004-01-13 Organ Transport Systems, Inc. Organ preservation apparatus and methods
US20040029266A1 (en) * 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
US7691622B2 (en) * 2003-04-04 2010-04-06 Lifeline Scientific, Inc. Method and apparatus for transferring heat to or from an organ or tissue container

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545225A (en) * 1968-08-16 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining whole organs in a viable state
US3772153A (en) * 1969-04-02 1973-11-13 Air Liquide Apparatus for the preservation of animal or human organs in living condition
US4460102A (en) * 1982-09-23 1984-07-17 Barringer Albert J Sealed container
FR2583386A1 (en) * 1985-06-12 1986-12-19 Sartec Service Ind Valve for package and package comprising such a valve.
WO1996039027A1 (en) * 1995-06-05 1996-12-12 Cytotherapeutics, Inc. Apparatus and method for storage and transportation of bioartificial organs
WO2002026034A2 (en) * 2000-08-25 2002-04-04 Organ Recovery Systems Inc. Apparatus and method for maintaining and/or restoring viability of organs
WO2002018210A1 (en) * 2000-08-28 2002-03-07 Automated Plastic Systems Pty Ltd. Medical transport container

Also Published As

Publication number Publication date
US20100112542A1 (en) 2010-05-06
US8389271B2 (en) 2013-03-05
US7691622B2 (en) 2010-04-06
US20040224299A1 (en) 2004-11-11
PL1613153T3 (en) 2021-11-29
CA2762971A1 (en) 2004-10-21
EP1613153B1 (en) 2021-06-02
US7678563B2 (en) 2010-03-16
CA2521324A1 (en) 2004-10-21
CA2762971C (en) 2015-07-21
US7998725B2 (en) 2011-08-16
ES2885752T3 (en) 2021-12-15
CA2521324C (en) 2014-12-09
US20100151559A1 (en) 2010-06-17
EP1613153A2 (en) 2006-01-11
CA2763269C (en) 2014-03-11
US20040248281A1 (en) 2004-12-09
US8097449B2 (en) 2012-01-17
WO2004089235A2 (en) 2004-10-21
US20040235142A1 (en) 2004-11-25
CA2763269A1 (en) 2004-10-21

Similar Documents

Publication Publication Date Title
WO2004089235A3 (en) Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue
WO2008077059A3 (en) Portable organ and tissue preservation apparatus, kit and methods
WO2005099588A3 (en) Apparatus and method for perfusing an organ or tissue for isolating cells from the organ or tissue
Dehghani et al. Design and preliminary evaluation of a self-steering, pneumatically driven colonoscopy robot
FI102723B (en) Drug container for providing a controlled environment
WO2005074681A3 (en) Apparatus and method for determining effects of a substance on an organ
EP1685788A4 (en) Capsule-type medical system
US7212128B2 (en) Mobile health and life signs detector
DE10196737T1 (en) Display method and device for an x-ray projection image for medical purposes, x-ray CT device for medical purposes and storage medium for storing a program for executing the display method
BRPI0715118B8 (en) therapy prescription system and apparatus
EP1769722A3 (en) Endoscope system comprising endoscope to which medical instrument is attached
AU2001289793A1 (en) Fluid cooled apparatus for supporting diagnostic and therapeutic elements in contact with tissue
WO2006118990A3 (en) Method and device for organ perfusion
CN116267894A (en) System and method for ex vivo lung care
YU20050440A (en) Patient cooling system
WO2007078827A3 (en) Visualization esophageal-tracheal airway apparatus and methods
GB2462561A (en) Ex vivo methods for testing organ system disruption
DE60334771D1 (en) EMISSION STORAGE SCANNER WITH OPEN ACCESS
Wang et al. Endoscopic closure of large colonic perforations with a novel endoscopic clip device: An animal study (with videos)
CN213567611U (en) Portable medical examination biochemical clinical blood sampling case
CN211187374U (en) Automatic opening object taking bag and object taking bag assembly under laparoscope
JP2019048776A (en) Transport device of organs and biological tissues
BRPI0418515A (en) apparatus for receiving, preserving and supplying blood bags
Shabbir et al. Closure of gastrotomy in natural orifice transluminal endoscopic surgery: a feasibility study using an ex vivo model comparing endoloop with endoclip
CN220244028U (en) Medical science inspection sample location storage box

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2521324

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004758782

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004758782

Country of ref document: EP