WO2004104644B1 - Method of sample control and calibration adjustment for use with a noninvasive analyzer - Google Patents

Method of sample control and calibration adjustment for use with a noninvasive analyzer

Info

Publication number
WO2004104644B1
WO2004104644B1 PCT/US2004/016064 US2004016064W WO2004104644B1 WO 2004104644 B1 WO2004104644 B1 WO 2004104644B1 US 2004016064 W US2004016064 W US 2004016064W WO 2004104644 B1 WO2004104644 B1 WO 2004104644B1
Authority
WO
WIPO (PCT)
Prior art keywords
spectrum
model
noninvasive
spectra
tissue
Prior art date
Application number
PCT/US2004/016064
Other languages
French (fr)
Other versions
WO2004104644A2 (en
WO2004104644A3 (en
Inventor
Timothy L Ruchti
Kevin H Hazen
Thomas B Blank
Original Assignee
Sensys Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/911,588 external-priority patent/US6115673A/en
Priority claimed from US09/563,782 external-priority patent/US6415167B1/en
Priority claimed from US09/630,201 external-priority patent/US6871169B1/en
Priority claimed from US10/170,921 external-priority patent/US7206623B2/en
Priority claimed from US10/384,023 external-priority patent/US7010336B2/en
Application filed by Sensys Medical Inc filed Critical Sensys Medical Inc
Priority to EP04752964A priority Critical patent/EP1626656A4/en
Publication of WO2004104644A2 publication Critical patent/WO2004104644A2/en
Publication of WO2004104644A3 publication Critical patent/WO2004104644A3/en
Publication of WO2004104644B1 publication Critical patent/WO2004104644B1/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274Calibration, base line adjustment, drift correction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495Calibrating or testing of in-vivo probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Abstract

A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference anaiyte concentration, with or without the use of a reference spectrum collected nearby in time.

Claims

59AMENDED CLAIMS [received by the International Burea on 25 March 2005 (25.03.05); original claims 1-29 replaced by new claims 1-32 (9 pages).]
1. A noninvasive method for estimating a biological attribute of human tissue of a tested subject, comprising the steps of: providing an apparatus for measuring light throughput, said apparatus comprising an energy source emitting light, an input element, an output element, and a spectrum analyzer; coupling said input and output elements to a targeted and controlled sample volume of said human tissue; irradiating said tissue through said input element with multiple wavelengths of said light energy, wherein said sample volume results in partial absorption of said light; collecting at least a portion of non-absorbed light energy with said output element; determining the intensities of said collected portion; generating a model, wherein said model uses calibration noninvasive spectra and calibration reference concentrations; adjusting said model with an estimated error, wherein said estimated error is generated with a spectrum of said targeted and controlled sample volume and with at least one direct reference measurement; collecting at least one prediction noninvasive spectrum of said targeted and controlled tissue volume of said tested subject; and estimating said biological attribute concentration of said tested subject using said adjusted model.
2. The method of Claim 1 , wherein said biological attribute comprises a glucose concentration.
3. The method of Claim 1 , wherein said light comprises near-infrared energy. 60
4. The method of Claim 3, wherein said near-infrared region comprises 1100 to 1900 nm or at least one sub-range therein.
5. The method of Claim 1 , wherein said calibration noninvasive spectra comprise spectra from any of: a single individual; multiple individuals; a single analyzer; and multiple analyzers.
6. The method of Claim 1 , wherein said model comprises a multivariate analysis.
7. The method of Claim 6, wherein said multivariate analysis comprises at least one of principal component regression and partial least squares.
8. The method of Claim 1 , wherein said direct reference measurement comprises at least one glucose concentration.
9. The method of Claim 1 , where said adjusting said model comprises:
Ymeas ~ Yhat "*" Yerr ~ measured' V "*" Ye >
wherein Xmeasured comprises a vector of a prediction spectrum, Wτ comprises a vector of coefficients associated with the said regression model, γhat comprises a resulting anaiyte concentration generated by said model prior to any correction, γer provides an estimated error of said resulting anaiyte concentration, and ymeas comprises said biological attribute concentration.
10. The method of Claim 1 , wherein use of said adjusted model comprises a time period of at least one of: a fraction of a day; a work day; 61 a waking portion of a day; a week; and a month.
11. The method of Claim 10, wherein said direct reference measurement comprises any of: a single reference glucose concentration; a reference glucose concentration determined before or in time proximity to beginning of said time period; and a set of at least two glucose concentrations.
12. The method of Claim 1 , further comprising a guide with a sample side and an attachment side wherein said sample side of said guide replaceably attaches to said human tissue and said attachment side of said guide replaceably attaches to at least one of said input element and said output element.
13. The method of Claim 11 , wherein said sample side of said guide comprises at least one of: a flat surface, and a surface with a radius of curvature ranging from flat to 1.5 centimeters.
14. A noninvasive method for estimating a biological attribute concentration in human tissue of a tested subject, comprising the steps of: generating a model, using noninvasive spectra and associated reference concentrations; adjusting said model with at least one direct reference measurement and without use of a corresponding reference spectrum; collecting at least one noninvasive spectrum of said tissue of said tested subject with an analyzer; and estimating said biological attribute of said specific subject using said adjusted model. 62
15. The method of Claim 14, further comprising a guide wherein said guide replaceably couples said analyzer to said human tissue.
16. A noninvasive method for estimating a biological attribute concentration of human tissue of a tested subject, comprising the steps of: providing an apparatus for measuring light throughput, said apparatus comprising an energy source emitting light at multiple wavelengths, an input element, an output element, and a spectrum analyzer; coupling said input and output elements to said human tissue using a guide, wherein said guide comprises an attachment side and a sample side; irradiating said tissue through said input element with multiple wavelengths of said light with resulting absorption of at least some of said wavelengths; collecting at least a portion of non-absorbed light with said output element; determining the intensities of said collected light; generating a model using calibration spectra and calibration reference concentrations; adjusting said model with at least one direct reference measurement and a corresponding reference spectrum; collecting at least one noninvasive prediction spectrum of said tissue of said tested subject; and estimating said biological attribute of said specific subject using said adjusted model.
17. The method of Claim 16, wherein said biological attribute comprises a glucose concentration.
18. The method of Claim 16, wherein said light comprises wavelengths from 1100 to 1900 nm or at least one sub-range therein.
19. The method of Claim 16, wherein said noninvasive calibration spectra comprise spectra from any of: 63 a single individual; multiple individuals; a single analyzer; and multiple analyzers.
20. The method of Claim 16, wherein said model comprises a multivariate analysis.
21. The method of Claim 20, wherein said multivariate analysis comprises at least one of principal component regression and partial least squares.
22. The method of Claim 16, wherein use of said adjusted model occurs for a time period comprising at least one of: a fraction of a day; a work day; a waking portion of a day; a week; and a month.
23. The method of Claim 22, wherein said direct reference measurement comprises any of: a single reference glucose concentration; a reference glucose concentration determined before or in time proximity to beginning of said time period; the first n reference glucose concentrations of said time period; and a set of at least two glucose concentrations.
24. The method of Claim 22, wherein said reference spectrum comprises any of a stored reference spectrum; a first spectrum of said time period; a spectrum of said specific subject; an average of the first n spectra of said time period; an average of the first n spectra of said specific subject; a set of at least two spectra of said specific subject; and a spectrum from a data base, wherein said spectrum is selected based upon at least one spectral feature.
25. The method of Claim 16, wherein said sample side of said guide replaceably attaches to said human tissue and said attachment side of said guide replaceably attaches to at least one of said input element and said output element.
26. The method of Claim 16, wherein said sample side of said guide comprises at least one of: a flat surface, and a surface with a radius of curvature ranging from flat to 1.5 centimeters.
27. The method of Claim 16, wherein said attachment side of said guide interfaces with at least one of: a plug; a photostimulator; a sample module; said input element; and said output element.
28. A noninvasive method for estimating a biological attribute concentration of a targeted human tissue of a tested subject, comprising the steps of: generating a model, using noninvasive spectra and associated reference concentrations; adjusting said model with an associated spectrum, wherein said associated spectrum is selected based upon spectral features representative of said targeted tissue from at least one of: a spectral library; 65 a linear combination of spectra; and at least one spectrum of said tested subject.
29. A noninvasive method for measuring a biological attribute of human tissue of a tested subject, comprising the steps of: providing an apparatus for measuring light throughput, said apparatus comprising an energy source emitting infrared energy at multiple wavelengths, an input element, an output element, and a spectrum analyzer; coupling said input and output elements to said human tissue; irradiating said tissue through said input element with multiple wavelengths of infrared energy with resulting absorption of at least some of said wavelengths; collecting at least a portion of the non-absorbed infrared energy with said output element; determining the intensities of said infrared energy; generating a model using calibration noninvasive spectra and calibration reference concentrations; adjusting said model with at least one direct reference measurement and without use of a corresponding reference spectrum; collecting at least one prediction noninvasive spectrum of said tissue of said tested subject; and estimating said biological attribute concentration of said specific subject using said adjusted model.
30. A noninvasive method for estimating a biological attribute of human tissue of a tested subject, comprising the steps of: providing an apparatus for measuring light, said apparatus comprising an energy source emitting light, an input element, an output element, a spectrum analyzer, and a model generated from calibration noninvasive spectra and calibration reference concentrations; coupling said input and output elements to a targeted and controlled sample volume of said human tissue; 66 irradiating said tissue through said input element with multiple wavelengths of said light energy, wherein said sample volume results in partial absorption of said light; collecting at least a portion of non-absorbed light energy with said output element: determining the intensities of said collected portion; adjusting said model with an estimated error, wherein said estimated error is generated with a spectrum of said targeted and controlled sample volume and with at least one direct reference measurement; collecting at least one prediction noninvasive spectrum of said targeted and controlled tissue volume of said tested subject; and estimating said biological attribute concentration of said tested subject using said adjusted model.
31. A noninvasive method for estimating a biological attribute of human tissue of a tested subject, comprising the steps of: providing an apparatus for measuring light throughput, said apparatus comprising an energy source emitting light, an input element, an output element, a spectrum analyzer, and a model generated from calibration noninvasive spectra and calibration reference concentrations; collecting at least one prediction noninvasive spectrum of a targeted and controlled tissue volume of said tested subject; adjusting said model with an estimated error, wherein said estimated error is generated with a spectrum of said targeted and controlled sample volume and with at least one direct reference measurement; and estimating said biological attribute concentration of said tested subject using said adjusted model.
32. A noninvasive analyzer for estimating a biological attribute of human tissue of a tested subject, comprising: 67 an apparatus for measuring light throughput, said apparatus comprising an energy source emitting light, an input element, an output element, and a spectrum analyzer; means for generating a model, wherein said model uses calibration noninvasive spectra and calibration reference concentrations; means for adjusting said model with an estimated error, wherein said estimated error is generated with a spectrum of said targeted and controlled sample volume and with at least one direct reference measurement.
PCT/US2004/016064 1997-08-14 2004-05-20 Method of sample control and calibration adjustment for use with a noninvasive analyzer WO2004104644A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04752964A EP1626656A4 (en) 1997-08-14 2004-05-20 Method of sample control and calibration adjustment for use with a noninvasive analyzer

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US08/911,588 US6115673A (en) 1997-08-14 1997-08-14 Method and apparatus for generating basis sets for use in spectroscopic analysis
US09/563,782 US6415167B1 (en) 2000-05-02 2000-05-02 Fiber optic probe placement guide
US61078900A 2000-07-06 2000-07-06
US09/630,201 US6871169B1 (en) 1997-08-14 2000-08-01 Combinative multivariate calibration that enhances prediction ability through removal of over-modeled regions
US10/170,921 US7206623B2 (en) 2000-05-02 2002-06-12 Optical sampling interface system for in vivo measurement of tissue
US10/384,023 US7010336B2 (en) 1997-08-14 2003-03-07 Measurement site dependent data preprocessing method for robust calibration and prediction
US47261303P 2003-05-21 2003-05-21
US60/472,613 2003-05-21
US10/849,422 US7383069B2 (en) 1997-08-14 2004-05-18 Method of sample control and calibration adjustment for use with a noninvasive analyzer
US10/849,422 2004-05-18

Publications (3)

Publication Number Publication Date
WO2004104644A2 WO2004104644A2 (en) 2004-12-02
WO2004104644A3 WO2004104644A3 (en) 2005-03-24
WO2004104644B1 true WO2004104644B1 (en) 2005-05-19

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US (2) US7383069B2 (en)
EP (1) EP1626656A4 (en)
WO (1) WO2004104644A2 (en)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE10057832C1 (en) * 2000-11-21 2002-02-21 Hartmann Paul Ag Blood analysis device has syringe mounted in casing, annular mounting carrying needles mounted behind test strip and being swiveled so that needle can be pushed through strip and aperture in casing to take blood sample
US8641644B2 (en) * 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
ES2357887T3 (en) 2001-06-12 2011-05-03 Pelikan Technologies Inc. APPARATUS FOR IMPROVING THE BLOOD OBTAINING SUCCESS RATE FROM A CAPILLARY PUNCTURE.
US20070100255A1 (en) * 2002-04-19 2007-05-03 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2002100254A2 (en) * 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CA2448902C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
EP1395185B1 (en) 2001-06-12 2010-10-27 Pelikan Technologies Inc. Electric lancet actuator
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7682318B2 (en) 2001-06-12 2010-03-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US7344507B2 (en) * 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7981056B2 (en) * 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
US7674232B2 (en) * 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7582099B2 (en) * 2002-04-19 2009-09-01 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7331931B2 (en) * 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7244265B2 (en) * 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) * 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7485128B2 (en) * 2002-04-19 2009-02-03 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7491178B2 (en) * 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7374544B2 (en) * 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7717863B2 (en) * 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7524293B2 (en) * 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) * 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US20070142748A1 (en) * 2002-04-19 2007-06-21 Ajay Deshmukh Tissue penetration device
US8784335B2 (en) * 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
EP1628567B1 (en) 2003-05-30 2010-08-04 Pelikan Technologies Inc. Method and apparatus for fluid injection
ES2490740T3 (en) 2003-06-06 2014-09-04 Sanofi-Aventis Deutschland Gmbh Apparatus for blood fluid sampling and analyte detection
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
EP1671096A4 (en) * 2003-09-29 2009-09-16 Pelikan Technologies Inc Method and apparatus for an improved sample capture device
EP1680014A4 (en) 2003-10-14 2009-01-21 Pelikan Technologies Inc Method and apparatus for a variable user interface
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9492114B2 (en) 2004-06-18 2016-11-15 Banner Health Systems, Inc. Accelerated evaluation of treatments to prevent clinical onset of alzheimer's disease
RU2266523C1 (en) * 2004-07-27 2005-12-20 Общество с ограниченной ответственностью ООО "ВИНТЕЛ" Method of producing independent multidimensional calibration models
US9471978B2 (en) 2004-10-04 2016-10-18 Banner Health Methodologies linking patterns from multi-modality datasets
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
EP1719447A1 (en) * 2005-05-07 2006-11-08 F. Hoffmann-La Roche AG Method and device for determining glucose concentration in lymph
US20070191736A1 (en) * 2005-10-04 2007-08-16 Don Alden Method for loading penetrating members in a collection device
US8419649B2 (en) 2007-06-12 2013-04-16 Sotera Wireless, Inc. Vital sign monitor for measuring blood pressure using optical, electrical and pressure waveforms
US8602997B2 (en) 2007-06-12 2013-12-10 Sotera Wireless, Inc. Body-worn system for measuring continuous non-invasive blood pressure (cNIBP)
US11330988B2 (en) 2007-06-12 2022-05-17 Sotera Wireless, Inc. Body-worn system for measuring continuous non-invasive blood pressure (cNIBP)
US11607152B2 (en) 2007-06-12 2023-03-21 Sotera Wireless, Inc. Optical sensors for use in vital sign monitoring
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US20100187132A1 (en) * 2008-12-29 2010-07-29 Don Alden Determination of the real electrochemical surface areas of screen printed electrodes
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8956294B2 (en) 2009-05-20 2015-02-17 Sotera Wireless, Inc. Body-worn system for continuously monitoring a patients BP, HR, SpO2, RR, temperature, and motion; also describes specific monitors for apnea, ASY, VTAC, VFIB, and ‘bed sore’ index
US8738118B2 (en) 2009-05-20 2014-05-27 Sotera Wireless, Inc. Cable system for generating signals for detecting motion and measuring vital signs
US11896350B2 (en) 2009-05-20 2024-02-13 Sotera Wireless, Inc. Cable system for generating signals for detecting motion and measuring vital signs
US8437824B2 (en) * 2009-06-17 2013-05-07 Sotera Wireless, Inc. Body-worn pulse oximeter
US20110066008A1 (en) 2009-09-14 2011-03-17 Matt Banet Body-worn monitor for measuring respiration rate
US20110066043A1 (en) * 2009-09-14 2011-03-17 Matt Banet System for measuring vital signs during hemodialysis
US10806351B2 (en) 2009-09-15 2020-10-20 Sotera Wireless, Inc. Body-worn vital sign monitor
US10420476B2 (en) 2009-09-15 2019-09-24 Sotera Wireless, Inc. Body-worn vital sign monitor
US8527038B2 (en) 2009-09-15 2013-09-03 Sotera Wireless, Inc. Body-worn vital sign monitor
US9060687B2 (en) 2009-10-02 2015-06-23 Sharp Kabushiki Kaisha Device for monitoring blood vessel conditions and method for monitoring same
CA2779300C (en) 2009-10-22 2018-11-27 The General Hospital Corporation Method and apparatus for skin stabilization and positioning
US20110224499A1 (en) 2010-03-10 2011-09-15 Sotera Wireless, Inc. Body-worn vital sign monitor
US9173604B2 (en) 2010-03-19 2015-11-03 Sharp Kabushiki Kaisha Measurement device, measurement method, measurement result processing device, measurement system, measurement result processing method, control program, and recording medium
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8747330B2 (en) 2010-04-19 2014-06-10 Sotera Wireless, Inc. Body-worn monitor for measuring respiratory rate
US8888700B2 (en) 2010-04-19 2014-11-18 Sotera Wireless, Inc. Body-worn monitor for measuring respiratory rate
US8979765B2 (en) 2010-04-19 2015-03-17 Sotera Wireless, Inc. Body-worn monitor for measuring respiratory rate
US9173593B2 (en) 2010-04-19 2015-11-03 Sotera Wireless, Inc. Body-worn monitor for measuring respiratory rate
US9173594B2 (en) 2010-04-19 2015-11-03 Sotera Wireless, Inc. Body-worn monitor for measuring respiratory rate
US9339209B2 (en) 2010-04-19 2016-05-17 Sotera Wireless, Inc. Body-worn monitor for measuring respiratory rate
US20120226117A1 (en) 2010-12-01 2012-09-06 Lamego Marcelo M Handheld processing device including medical applications for minimally and non invasive glucose measurements
SG191380A1 (en) 2010-12-28 2013-07-31 Sotera Wireless Inc Body-worn system for continous, noninvasive measurement of cardiac output, stroke volume, cardiac power, and blood pressure
US10357187B2 (en) 2011-02-18 2019-07-23 Sotera Wireless, Inc. Optical sensor for measuring physiological properties
SG192836A1 (en) 2011-02-18 2013-09-30 Sotera Wireless Inc Modular wrist-worn processor for patient monitoring
US20130317368A1 (en) 2012-03-12 2013-11-28 Ivwatch, Llc System for Mitigating the Effects of Tissue Blood Volume Changes to Aid in Diagnosing Infiltration or Extravasation in Animalia Tissue
US9351672B2 (en) 2012-07-16 2016-05-31 Timothy Ruchti Multiplexed pathlength resolved noninvasive analyzer apparatus with stacked filters and method of use thereof
US9351671B2 (en) 2012-07-16 2016-05-31 Timothy Ruchti Multiplexed pathlength resolved noninvasive analyzer apparatus and method of use thereof
US9766126B2 (en) 2013-07-12 2017-09-19 Zyomed Corp. Dynamic radially controlled light input to a noninvasive analyzer apparatus and method of use thereof
US9585604B2 (en) 2012-07-16 2017-03-07 Zyomed Corp. Multiplexed pathlength resolved noninvasive analyzer apparatus with dynamic optical paths and method of use thereof
CA2867138C (en) * 2013-01-22 2021-03-02 Ivwatch, Llc Geometry of a transcutaneous sensor
WO2016054079A1 (en) 2014-09-29 2016-04-07 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US11596331B2 (en) 2018-10-04 2023-03-07 Samsung Electronics Co., Ltd. Apparatus and method for estimating analyte concentration
KR20200137103A (en) 2019-05-29 2020-12-09 삼성전자주식회사 Apparatus and method for updating bio-information estimation model
US11766221B1 (en) * 2020-03-25 2023-09-26 Tula Health, Inc. Devices, systems, and methods for measurement validation for chronic health condition management
US20230038906A1 (en) * 2021-08-06 2023-02-09 Rockley Photonics Limited System and method for positioning a sensor on a subject

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5411065Y2 (en) 1975-08-11 1979-05-19
DE2640987C3 (en) 1976-09-11 1982-06-09 Drägerwerk AG, 2400 Lübeck Transducer for the transcutaneous measurement of gases in the blood
US4281645A (en) 1977-06-28 1981-08-04 Duke University, Inc. Method and apparatus for monitoring metabolism in body organs
US4893253A (en) 1988-03-10 1990-01-09 Indiana University Foundation Method for analyzing intact capsules and tablets by near-infrared reflectance spectrometry
US5077476A (en) * 1990-06-27 1991-12-31 Futrex, Inc. Instrument for non-invasive measurement of blood glucose
WO1991003755A1 (en) 1989-08-29 1991-03-21 Fibotech, Inc. High precision fiberoptic alignment spring receptacle and fiberoptic probe
JP3213307B2 (en) 1989-09-18 2001-10-02 ミネソタ マイニング アンド マニユフアクチユアリング カンパニー A method for predicting the properties of biological materials by near-infrared spectral analysis
US5070874A (en) 1990-01-30 1991-12-10 Biocontrol Technology, Inc. Non-invasive determination of glucose concentration in body of patients
EP0613652B1 (en) 1990-02-15 1997-04-16 Hewlett-Packard GmbH Apparatus and method for non-invasive measurement of oxygen saturation
US5170786A (en) 1990-09-28 1992-12-15 Novametrix Medical Systems, Inc. Reusable probe system
DE69227545T2 (en) 1991-07-12 1999-04-29 Mark R Robinson Oximeter for the reliable clinical determination of blood oxygen saturation in a fetus
DE59202684D1 (en) 1991-08-12 1995-08-03 Avl Medical Instr Ag Device for measuring at least one gas saturation, in particular the oxygen saturation of blood.
DE69218536T2 (en) 1991-10-04 1997-07-03 Perkin Elmer Corp Method and device for comparing spectra
US5239366A (en) 1992-02-12 1993-08-24 Huges Aircraft Company Compact laser probe for profilometry
DK39792D0 (en) 1992-03-25 1992-03-25 Foss Electric As PROCEDURE FOR DETERMINING A COMPONENT
US5348002A (en) 1992-04-23 1994-09-20 Sirraya, Inc. Method and apparatus for material analysis
US5542421A (en) * 1992-07-31 1996-08-06 Frederick Erdman Association Method and apparatus for cardiovascular diagnosis
US5379764A (en) 1992-12-09 1995-01-10 Diasense, Inc. Non-invasive determination of analyte concentration in body of mammals
US5636634A (en) 1993-03-16 1997-06-10 Ep Technologies, Inc. Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes
JPH0799027A (en) 1993-08-05 1995-04-11 Mitsubishi Electric Corp Electron beam focusing device
WO1995006431A2 (en) 1993-08-24 1995-03-09 Robinson Mark R A robust accurate non-invasive analyte monitor
US5462879A (en) 1993-10-14 1995-10-31 Minnesota Mining And Manufacturing Company Method of sensing with emission quenching sensors
US5492118A (en) 1993-12-16 1996-02-20 Board Of Trustees Of The University Of Illinois Determining material concentrations in tissues
DE4415896A1 (en) 1994-05-05 1995-11-09 Boehringer Mannheim Gmbh Analysis system for monitoring the concentration of an analyte in the blood of a patient
GB9415869D0 (en) 1994-08-05 1994-09-28 Univ Mcgill Substrate measurement by infrared spectroscopy
US5536634A (en) * 1994-09-30 1996-07-16 Eastman Kodak Company Silver halide emulsions spectrally sensitized in the presence of low N-alkyl pyridinium ions
EP0722691A1 (en) 1994-12-24 1996-07-24 Roche Diagnostics GmbH System for determining properties of tissue
DE19506484C2 (en) 1995-02-24 1999-09-16 Stiftung Fuer Lasertechnologie Method and device for selective non-invasive laser myography (LMG)
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
WO1996032631A1 (en) 1995-04-13 1996-10-17 Pfizer Inc. Calibration tranfer standards and methods
WO1996033459A1 (en) 1995-04-18 1996-10-24 International Business Machines Corporation High available error self-recovering shared cache for multiprocessor systems
JPH08299310A (en) 1995-05-02 1996-11-19 Toa Medical Electronics Co Ltd Non-invasive blood analysis device and method therefor
US5743262A (en) 1995-06-07 1998-04-28 Masimo Corporation Blood glucose monitoring system
US5638816A (en) 1995-06-07 1997-06-17 Masimo Corporation Active pulse blood constituent monitoring
US5606164A (en) 1996-01-16 1997-02-25 Boehringer Mannheim Corporation Method and apparatus for biological fluid analyte concentration measurement using generalized distance outlier detection
EP0846253A4 (en) 1995-08-07 2009-11-11 Roche Diagnostics Operations Biological fluid analysis using distance outlier detection
US5655530A (en) * 1995-08-09 1997-08-12 Rio Grande Medical Technologies, Inc. Method for non-invasive blood analyte measurement with improved optical interface
US6240306B1 (en) 1995-08-09 2001-05-29 Rio Grande Medical Technologies, Inc. Method and apparatus for non-invasive blood analyte measurement with fluid compartment equilibration
US6152876A (en) 1997-04-18 2000-11-28 Rio Grande Medical Technologies, Inc. Method for non-invasive blood analyte measurement with improved optical interface
JPH09122128A (en) 1995-10-31 1997-05-13 Kdk Corp Measurement condition reproducing tool, measurement condition reproducing method and biological information utilizing the same
DE19543020A1 (en) 1995-11-18 1997-05-22 Boehringer Mannheim Gmbh Method and device for determining analytical data on the interior of a scattering matrix
US5619195A (en) 1995-12-29 1997-04-08 Charles D. Hayes Multi-axial position sensing apparatus
US5661843A (en) 1996-01-30 1997-08-26 Rifocs Corporation Fiber optic probe
US5747806A (en) 1996-02-02 1998-05-05 Instrumentation Metrics, Inc Method and apparatus for multi-spectral analysis in noninvasive nir spectroscopy
US6040578A (en) 1996-02-02 2000-03-21 Instrumentation Metrics, Inc. Method and apparatus for multi-spectral analysis of organic blood analytes in noninvasive infrared spectroscopy
FI118509B (en) * 1996-02-12 2007-12-14 Nokia Oyj A method and apparatus for predicting blood glucose levels in a patient
US5725480A (en) 1996-03-06 1998-03-10 Abbott Laboratories Non-invasive calibration and categorization of individuals for subsequent non-invasive detection of biological compounds
US5671317A (en) 1996-07-16 1997-09-23 Health Research, Inc. Fiber optic positioner
DE69737031T2 (en) 1996-07-19 2007-04-26 Daedalus I, Llc DEVICE FOR NON-INVASIVE DETERMINATION OF BLOOD PARAMETERS
US6415167B1 (en) * 2000-05-02 2002-07-02 Instrumentation Metrics, Inc. Fiber optic probe placement guide
US6115673A (en) 1997-08-14 2000-09-05 Instrumentation Metrics, Inc. Method and apparatus for generating basis sets for use in spectroscopic analysis
US7206623B2 (en) 2000-05-02 2007-04-17 Sensys Medical, Inc. Optical sampling interface system for in vivo measurement of tissue
US5869075A (en) 1997-08-15 1999-02-09 Kimberly-Clark Worldwide, Inc. Soft tissue achieved by applying a solid hydrophilic lotion
ES2322782T3 (en) 1997-09-25 2009-06-26 Siemens Healthcare Diagnostics Inc. SPECTROSCOPIC ANALYSIS OF SAMPLES WITH TURBIDITY AND HIGH ABSORBANCE.
US6119026A (en) 1997-12-04 2000-09-12 Hewlett-Packard Company Radiation apparatus and method for analysis of analytes in sample
US5978697A (en) 1998-01-05 1999-11-02 Galil Medical Ltd. System and method for MRI-guided cryosurgery
US5956150A (en) 1998-02-02 1999-09-21 Motorola, Inc. Laser mount positioning device and method of using same
US5891021A (en) 1998-06-03 1999-04-06 Perdue Holdings, Inc. Partially rigid-partially flexible electro-optical sensor for fingertip transillumination
US6441388B1 (en) 1998-10-13 2002-08-27 Rio Grande Medical Technologies, Inc. Methods and apparatus for spectroscopic calibration model transfer
US6157041A (en) 1998-10-13 2000-12-05 Rio Grande Medical Technologies, Inc. Methods and apparatus for tailoring spectroscopic calibration models
WO2000022985A1 (en) 1998-10-22 2000-04-27 Children's Hospital, Inc. Apparatus for controlled ventilation of a patient
US6585370B2 (en) 1998-11-02 2003-07-01 Gary M. Zelman Removable lens frame mounted to an eyewear platform
US6280381B1 (en) 1999-07-22 2001-08-28 Instrumentation Metrics, Inc. Intelligent system for noninvasive blood analyte prediction
JP2002535023A (en) 1999-01-22 2002-10-22 インストルメンテーション メトリックス インコーポレイテッド Systems and methods for non-invasive blood analysis measurements
US6341257B1 (en) 1999-03-04 2002-01-22 Sandia Corporation Hybrid least squares multivariate spectral analysis methods
US6959211B2 (en) 1999-03-10 2005-10-25 Optiscan Biomedical Corp. Device for capturing thermal spectra from tissue
DE60032134T2 (en) 1999-06-11 2007-10-25 Altea Therapeutics Corp. ALIGNMENT DEVICES FOR FLUID RECOVERY FROM TISSUE AND FOR SUBSTANCE DISPENSING
EP1198196A4 (en) 1999-07-14 2007-05-02 Providence Health Sys Oregon Adaptive calibration pulsed oximetry method and device
IL156844A0 (en) * 2001-01-26 2004-02-08 Sensys Medical Inc Noninvasive measurement of glucose through the optical properties of tissue
US6631282B2 (en) * 2001-08-09 2003-10-07 Optiscan Biomedical Corporation Device for isolating regions of living tissue
US20070093698A1 (en) * 2005-10-20 2007-04-26 Glucon Inc. Apparatus and methods for attaching a device to a body

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