WO2005016401A3 - Improved intra-dermal delivery of biologically active agents - Google Patents

Improved intra-dermal delivery of biologically active agents Download PDF

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Publication number
WO2005016401A3
WO2005016401A3 PCT/US2004/019121 US2004019121W WO2005016401A3 WO 2005016401 A3 WO2005016401 A3 WO 2005016401A3 US 2004019121 W US2004019121 W US 2004019121W WO 2005016401 A3 WO2005016401 A3 WO 2005016401A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved
biologically active
active agents
delivery
rapid
Prior art date
Application number
PCT/US2004/019121
Other languages
French (fr)
Other versions
WO2005016401A2 (en
Inventor
Colleen Nycz
Glenn Vonk
John Brittingham
Ronald J Pettis
Alfred Harvey
Robert Campbell
John Mikszta
Original Assignee
Becton Dickinson Co
Colleen Nycz
Glenn Vonk
John Brittingham
Ronald J Pettis
Alfred Harvey
Robert Campbell
John Mikszta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co, Colleen Nycz, Glenn Vonk, John Brittingham, Ronald J Pettis, Alfred Harvey, Robert Campbell, John Mikszta filed Critical Becton Dickinson Co
Priority to JP2006533803A priority Critical patent/JP2007500251A/en
Priority to EP04776619A priority patent/EP1635876A4/en
Priority to CA002529048A priority patent/CA2529048A1/en
Priority to AU2004264839A priority patent/AU2004264839B2/en
Priority to BRPI0411428-0A priority patent/BRPI0411428A/en
Publication of WO2005016401A2 publication Critical patent/WO2005016401A2/en
Publication of WO2005016401A3 publication Critical patent/WO2005016401A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Abstract

The present invention relates to methods and devices for delivering one or more biologically active agents, particularly a diagnostic agent to the intradermal compartment of a subject’s skin. The present invention provides an improved method of delivery of biologically active agents in that it provides among other benefits, rapid uptake into the local lymphatics, improved targeting to a particular tissue, improved bioavailability, improved tissue bioavailability, improved tissue specific kinetics, improved deposition of a pre-selected volume of the agent to be administered, and rapid biological and rapid biological and pharmacodynamics and biological and pharmacokinetics. This invention provides methods for rapid transport of agents through lymphatic vasculature accessed by intradermal delivery of the agent. Methods of the invention are particularly useful for delivery of diagnostic agents.
PCT/US2004/019121 2003-06-13 2004-06-14 Improved intra-dermal delivery of biologically active agents WO2005016401A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2006533803A JP2007500251A (en) 2003-06-13 2004-06-14 Improved intradermal delivery of biologically active agents
EP04776619A EP1635876A4 (en) 2003-06-13 2004-06-14 Improved intra-dermal delivery of biologically active agents
CA002529048A CA2529048A1 (en) 2003-06-13 2004-06-14 Improved intra-dermal delivery of biologically active agents
AU2004264839A AU2004264839B2 (en) 2003-06-13 2004-06-14 Improved intra-dermal delivery of biologically active agents
BRPI0411428-0A BRPI0411428A (en) 2003-06-13 2004-06-14 intradermal distribution of biologically active agents

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US47795003P 2003-06-13 2003-06-13
US60/477,950 2003-06-13
US48992003P 2003-07-25 2003-07-25
US60/489,920 2003-07-25
US50222503P 2003-09-12 2003-09-12
US60/502,225 2003-09-12
US53847304P 2004-01-26 2004-01-26
US60/538,473 2004-01-26

Publications (2)

Publication Number Publication Date
WO2005016401A2 WO2005016401A2 (en) 2005-02-24
WO2005016401A3 true WO2005016401A3 (en) 2005-11-24

Family

ID=34199237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019121 WO2005016401A2 (en) 2003-06-13 2004-06-14 Improved intra-dermal delivery of biologically active agents

Country Status (7)

Country Link
US (1) US20050163711A1 (en)
EP (1) EP1635876A4 (en)
JP (1) JP2007500251A (en)
AU (1) AU2004264839B2 (en)
BR (1) BRPI0411428A (en)
CA (1) CA2529048A1 (en)
WO (1) WO2005016401A2 (en)

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JP2007500251A (en) 2007-01-11
WO2005016401A2 (en) 2005-02-24
BRPI0411428A (en) 2006-07-25
EP1635876A2 (en) 2006-03-22
AU2004264839B2 (en) 2009-06-04
CA2529048A1 (en) 2005-02-24
EP1635876A4 (en) 2009-05-06
US20050163711A1 (en) 2005-07-28

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