WO2005021077A1 - Embryo transfer catheters and assemblies - Google Patents

Embryo transfer catheters and assemblies Download PDF

Info

Publication number
WO2005021077A1
WO2005021077A1 PCT/GB2004/003290 GB2004003290W WO2005021077A1 WO 2005021077 A1 WO2005021077 A1 WO 2005021077A1 GB 2004003290 W GB2004003290 W GB 2004003290W WO 2005021077 A1 WO2005021077 A1 WO 2005021077A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
assembly according
elongate member
tip
assembly
Prior art date
Application number
PCT/GB2004/003290
Other languages
French (fr)
Inventor
John Edward Nash
Original Assignee
Smiths Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smiths Group Plc filed Critical Smiths Group Plc
Publication of WO2005021077A1 publication Critical patent/WO2005021077A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M2025/0004—Catheters; Hollow probes having two or more concentrically arranged tubes for forming a concentric catheter system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0662—Guide tubes
    • A61M2025/0681—Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0133—Tip steering devices
    • A61M25/0147—Tip steering devices with movable mechanical means, e.g. pull wires

Definitions

  • This invention relates to assemblies of the kind including an outer sheath and an embryo transfer catheter slidably received within the sheath to project therefrom at its patient end, the catheter having a first passage therein for containing an embryo and an opening towards its patient end through which the embryo can be expelled.
  • Embryo transfer catheters are used to transfer an embryo to the uterus of a patient.
  • the catheter is usually introduced through the cervix by sliding along a shorter outer sheath, which provides greater rigidity and thereby facilitates introduction.
  • the catheter itself is preferably flexible with a soft, rounded tip to reduce the risk of damage to the lining of the uterus. This procedure is described in greater detail in GB 2209673.
  • an assembly of the above-specified kind characterised in that the assembly is arranged to enable the tip of the catheter to be bent by the user while it is position in the patient.
  • the catheter may include an elongate member extending along and attached with the catheter towards its patient end and accessible towards the machine end of the catheter whereby the patient end of the catheter protruding from the sheath can be steered by manipulating the machine end of the elongate member.
  • the elongate member is preferably a pull rod that can be pulled to cause the patient end of the catheter to bend.
  • the elongate member may be attached to a rotatable member at the machine end that is rotated to displace the elongate member axially and bend the patient end of the catheter.
  • the catheter preferably has a second passage along which the elongate member extends.
  • the catheter may include an electrical arrangement for bending the tip of the catheter.
  • the electrical arrangement may include a material that changes length when a current flows through it, the material extending along a part at least of the length of the catheter.
  • the assembly may include a handle containing a battery and a switch arranged to control the supply of power to the electrical arrangement.
  • Figure 1 is a perspective view of the assembly
  • Figure 2 is a perspective view of the patient end of the assembly showing the tip of the catheter bent
  • Figure 3 is a partly cut-away view of the patient end of the catheter
  • Figure 4 is a cross-sectional side elevation view of the machine end of the catheter
  • Figure 5 is a perspective view of an alternative catheter
  • Figure 6 is an enlarged perspective view of a part of the catheter in Figure 5 ;
  • Figure 7 is a cut-away view through the shaft of the catheter of Figures 5 and 6.
  • the assembly comprises an embryo transfer catheter 1 and an outer sheath 2 within which the catheter is slidable.
  • the catheter 1 has a shaft 10 and a hub assembly 11 at its machine end 12.
  • the shaft 10 is either 180mm or 230mm long and is extruded from a flexible plastics material such as PVC or polyurethane with a figure-of-eight cross-section having two circular bores 13 and 14 extending side-by-side along its length.
  • One bore 13 is for use in receiving and transferring an embryo and opens at the patient end 15 of the shaft 10 through a side aperture 16.
  • the patient end 15 of the shaft 10 is smoothly rounded and atraumatic.
  • the other end of the bore 13 opens through a side port 17 extending radially outwardly at an angle from a forward hub body 18.
  • the other bore 14 has a slightly larger diameter and provides a channel for a flexible pull rod 19 or similar elongate member.
  • the pull rod 19 may be of various different materials such as metal, plastics, glass fibre or the like, providing it can slide freely along the bore 14 and is relatively inextensible.
  • the forward end of the rod 19 is attached fixedly with the patient end 15 of the shaft 10 and the rear end passes through a bore 20 in the forward hub body 18, being attached fixedly with a rear hub body 21. Both the forward and rear hub bodies 18 and 21 have knurls 22 to assist gripping
  • the forward hub body 18 has an externally-threaded boss 23 through which the bore 20 and pull rod 19 extend, the boss extending axially rearwardly of the hub body.
  • the rear hub body 21 has an internally-threaded sleeve 24 extending axially forwardly and screwed onto the boss 23 of the forward body 18. If the rear hub body 21 is twisted anticlockwise relative to the forward body 18, it is jacked rearwardly relative to the forward body, thereby pulling back the pull rod 19. Because the pull rod bore 14 extends on one side of the shaft 10, pulling on the rod 19 will bend the patient end 15 of the shaft to one side, in the direction of the pull rod bore, as seen in Figure 2. If, instead, the rear hub body 21 is screwed in a clockwise direction, it moves towards the forward body 18, thereby allowing the pull rod 19 to move forwardly and the shaft 10 to straighten.
  • the assembly of the catheter 1 and sheath 2 is inserted through the cervix with the catheter initially pulled back so that its tip 15 is level with the forward end of the sheath.
  • the assembly has sufficient stiffness to be pushed through the cervix without buckling.
  • the catheter 1 can be pushed forwardly so that it slides relative to the sheath.
  • the catheter 1 is then manipulated to bring its opening 16 to the desired location.
  • the tip 15 of the catheter 1 can be bent by adjustment of the relative axial spacing of the forward and rear hub bodies 18 and 21.
  • the embryo is ejected tlirough the opening 16 by fluid pressure, such as that exerted by means of a syringe connected to the port 17.
  • the catheter could have a relatively stiff elongate member so that it could be pushed to deflect the end of the shaft in the opposite direction.
  • the pull rod or other elongate member could be displaced instead of the threaded arrangement described above.
  • the elongate member could simply have a handle that was pulled or pushed, or there could be some form of cam or lever operable to move the elongate member forwardly or rearwardly.
  • the shaft of the catheter could be bent in other ways than by means of an elongate rod that is pulled or pushed. Instead, for example, the catheter shaft could be bent electrically, as shown in Figures 5 to 7.
  • the catheter 30 shown in Figures 5 to 7 has a handle 31 and a shaft 32.
  • the handle 31 has torpedo shape and contains an integral syringe with a plunger 33, which projects from the rear of the handle.
  • the plunger 33 has a twist lock so that it can be locked in its outer position, as shown in Figures 5 and 6, and has to be twisted to unlock it before the clinician can push it in to eject the embryo from the catheter.
  • the handle 31 also houses a battery and electronics (not shown) and has two push buttons 34 and 35 towards its forward, patient end, which the clinician presses to bend or straighten respectively the tip of the catheter.
  • the shaft 32 of the catheter is shown most clearly in Figure 7.
  • the shaft 32 has a central bore 36 and is divided into two parts 37 and 38 across its diameter.
  • One part 37 is of a material that contracts when an electrical current is applied to it, such as including an electrostrictive material.
  • the other part 38 is of an electrically insulating plastics material and has an electrical wire 39 extending along its length. At its patient end, the wire 39 connects with the patient end of the contractive part 37.
  • the machine end of the contractive part 37 connects with the electronics in the handle 31. When the clinician presses the "Bend" button 34, the electronics within the handle 31 applies a current to the wire 39 so that current flows through the contractive part 37.

Abstract

An embryo transfer catheter assembly has a catheter (1), which can be advanced along an outer sheath (2). The catheter (1) has a first passage (13) opening at its tip (15) by which an embryo can be transferred to the uterus. A pull rod (19) attached at one end with the tip (15 )of the catheter extends along a second passage (14) alongside the first (13). The other end of the pull rod (19) is attached to a hub (21), which is screw threaded onto the catheter hub (18). The tip (15) of the catheter (1) can be bent to one side by unscrewing the hub (21) of the pull rod (19) from the catheter hub (18) so that it moves rearwardly and pulls the pull rod and the tip of the catheter, thereby bending it to one side. Alternatively, one side of the catheter (30) could include an electrically contractive material (37) so that, when a current is applied, the side reduces in length and pulls the tip to one side.

Description

EMBRYO TRANSFER CATHETERS AND ASSEMBLIES
This invention relates to assemblies of the kind including an outer sheath and an embryo transfer catheter slidably received within the sheath to project therefrom at its patient end, the catheter having a first passage therein for containing an embryo and an opening towards its patient end through which the embryo can be expelled.
Embryo transfer catheters are used to transfer an embryo to the uterus of a patient. The catheter is usually introduced through the cervix by sliding along a shorter outer sheath, which provides greater rigidity and thereby facilitates introduction. The catheter itself is preferably flexible with a soft, rounded tip to reduce the risk of damage to the lining of the uterus. This procedure is described in greater detail in GB 2209673.
It is an object of the present invention to provide an alternative embryo transfer catheter and assembly.
According to one aspect of the present invention there is provided an assembly of the above-specified kind, characterised in that the assembly is arranged to enable the tip of the catheter to be bent by the user while it is position in the patient.
The catheter may include an elongate member extending along and attached with the catheter towards its patient end and accessible towards the machine end of the catheter whereby the patient end of the catheter protruding from the sheath can be steered by manipulating the machine end of the elongate member. The elongate member is preferably a pull rod that can be pulled to cause the patient end of the catheter to bend. The elongate member may be attached to a rotatable member at the machine end that is rotated to displace the elongate member axially and bend the patient end of the catheter. The catheter preferably has a second passage along which the elongate member extends. Alternatively, the catheter may include an electrical arrangement for bending the tip of the catheter. The electrical arrangement may include a material that changes length when a current flows through it, the material extending along a part at least of the length of the catheter. The assembly may include a handle containing a battery and a switch arranged to control the supply of power to the electrical arrangement.
According to another aspect of the present invention there is provided a catheter for an assembly according to the above one aspect of the present invention.
Embryo transfer catheter assemblies according to the present invention, will now be described, by way of example, with reference to the accompanying drawings, in which:
Figure 1 is a perspective view of the assembly;
Figure 2 is a perspective view of the patient end of the assembly showing the tip of the catheter bent;
Figure 3 is a partly cut-away view of the patient end of the catheter;
Figure 4 is a cross-sectional side elevation view of the machine end of the catheter;
Figure 5 is a perspective view of an alternative catheter;
Figure 6 is an enlarged perspective view of a part of the catheter in Figure 5 ; and
Figure 7 is a cut-away view through the shaft of the catheter of Figures 5 and 6.
With reference first to Figures 1 to 4, the assembly comprises an embryo transfer catheter 1 and an outer sheath 2 within which the catheter is slidable.
The catheter 1 has a shaft 10 and a hub assembly 11 at its machine end 12. The shaft 10 is either 180mm or 230mm long and is extruded from a flexible plastics material such as PVC or polyurethane with a figure-of-eight cross-section having two circular bores 13 and 14 extending side-by-side along its length. One bore 13 is for use in receiving and transferring an embryo and opens at the patient end 15 of the shaft 10 through a side aperture 16. The patient end 15 of the shaft 10 is smoothly rounded and atraumatic. The other end of the bore 13 opens through a side port 17 extending radially outwardly at an angle from a forward hub body 18. The other bore 14 has a slightly larger diameter and provides a channel for a flexible pull rod 19 or similar elongate member. The pull rod 19 may be of various different materials such as metal, plastics, glass fibre or the like, providing it can slide freely along the bore 14 and is relatively inextensible. The forward end of the rod 19 is attached fixedly with the patient end 15 of the shaft 10 and the rear end passes through a bore 20 in the forward hub body 18, being attached fixedly with a rear hub body 21. Both the forward and rear hub bodies 18 and 21 have knurls 22 to assist gripping
The forward hub body 18 has an externally-threaded boss 23 through which the bore 20 and pull rod 19 extend, the boss extending axially rearwardly of the hub body. The rear hub body 21 has an internally-threaded sleeve 24 extending axially forwardly and screwed onto the boss 23 of the forward body 18. If the rear hub body 21 is twisted anticlockwise relative to the forward body 18, it is jacked rearwardly relative to the forward body, thereby pulling back the pull rod 19. Because the pull rod bore 14 extends on one side of the shaft 10, pulling on the rod 19 will bend the patient end 15 of the shaft to one side, in the direction of the pull rod bore, as seen in Figure 2. If, instead, the rear hub body 21 is screwed in a clockwise direction, it moves towards the forward body 18, thereby allowing the pull rod 19 to move forwardly and the shaft 10 to straighten.
In use, the assembly of the catheter 1 and sheath 2 is inserted through the cervix with the catheter initially pulled back so that its tip 15 is level with the forward end of the sheath. The assembly has sufficient stiffness to be pushed through the cervix without buckling. When the sheath 2 has been inserted to the desired depth, the catheter 1 can be pushed forwardly so that it slides relative to the sheath. The catheter 1 is then manipulated to bring its opening 16 to the desired location. Where necessary, the tip 15 of the catheter 1 can be bent by adjustment of the relative axial spacing of the forward and rear hub bodies 18 and 21. When correctly located, the embryo is ejected tlirough the opening 16 by fluid pressure, such as that exerted by means of a syringe connected to the port 17.
The invention could be modified in various ways. For example, instead of a pull rod, the catheter could have a relatively stiff elongate member so that it could be pushed to deflect the end of the shaft in the opposite direction. There are many arrangements by which the pull rod or other elongate member could be displaced instead of the threaded arrangement described above. For example, the elongate member could simply have a handle that was pulled or pushed, or there could be some form of cam or lever operable to move the elongate member forwardly or rearwardly.
The shaft of the catheter could be bent in other ways than by means of an elongate rod that is pulled or pushed. Instead, for example, the catheter shaft could be bent electrically, as shown in Figures 5 to 7. The catheter 30 shown in Figures 5 to 7 has a handle 31 and a shaft 32. The handle 31 has torpedo shape and contains an integral syringe with a plunger 33, which projects from the rear of the handle. The plunger 33 has a twist lock so that it can be locked in its outer position, as shown in Figures 5 and 6, and has to be twisted to unlock it before the clinician can push it in to eject the embryo from the catheter. The handle 31 also houses a battery and electronics (not shown) and has two push buttons 34 and 35 towards its forward, patient end, which the clinician presses to bend or straighten respectively the tip of the catheter.
The shaft 32 of the catheter is shown most clearly in Figure 7. The shaft 32 has a central bore 36 and is divided into two parts 37 and 38 across its diameter. One part 37 is of a material that contracts when an electrical current is applied to it, such as including an electrostrictive material. The other part 38 is of an electrically insulating plastics material and has an electrical wire 39 extending along its length. At its patient end, the wire 39 connects with the patient end of the contractive part 37. The machine end of the contractive part 37 connects with the electronics in the handle 31. When the clinician presses the "Bend" button 34, the electronics within the handle 31 applies a current to the wire 39 so that current flows through the contractive part 37. This causes the contractive part 37 to reduce in length, thereby bending the shaft 32 with the contractive part on the inside of the bend. The clinician can then release the plunger 32 and eject the embryo. When this has been done he presses the "Straighten" button 35 causing termination of current to the contractive part 37. The contractive material need not extend along the entire length of the shaft 32 since it may only be necessary for a few centimetres at the tip of the catheter to bend. It will be appreciated that, instead of a material that contracts, it would be possible to provide a shaft with a material that expands when current is applied to it. Such a shaft would bend with the expansible part on the outside of the bend.

Claims

1. An assembly of an outer sheath (2) and an embryo transfer catheter (1) slidably received within the sheath to project therefrom at its patient end, the catheter having a first passage (13) therein for containing an embryo and an opening (16) towards its patient end (15) through which the embryo can be expelled, characterised in that the assembly is arranged to enable the tip (15) of the catheter (1) to be bent by the user while it is position in the patient.
2. An assembly according to Claim 1, characterised in that the catheter (1) includes an elongate member (19) extending along and attached with the catheter towards its patient end (15) and accessible towards the machine end (12) of the catheter whereby the patient end of the catheter protruding from the sheath (2) can be steered by manipulating the machine end (21) of the elongate member.
3. An assembly according to Claim 2, characterised in that the elongate member is a pull rod (19) that can be pulled to cause the patient end (15) of the catheter (1) to bend.
4. An assembly according to Claim 2 or 3, characterised in that the elongate member (19) is attached to a rotatable member (21) at the machine end that is rotated to displace the elongate member axially and bend the patient end (15) of the catheter (1).
5. An assembly according to any one of Claims 2 to 4, characterised in that the catheter (1) has a second passage (14) along which the elongate member (19) extends.
6. An assembly according to Claim 1, characterised in that the catheter includes an electrical arrangement (31, 34, 35, 37, 39) for bending the tip of the catheter.
7. An assembly according to Claim 6, characterised in that the electrical arrangement includes a material (37) that changes length when a current flows through it, and that the material (37) extends along a part at least of the length of the catheter.
8. An assembly according to Claim 6 or 1, characterised in that the assembly includes a handle (31) containing a battery and a switch (34, 35) arranged to control the supply of power to the electrical arrangement (37, 39).
9. A catheter (1) for an assembly according to any one of the preceding claims.
PCT/GB2004/003290 2003-08-27 2004-07-29 Embryo transfer catheters and assemblies WO2005021077A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0320016A GB0320016D0 (en) 2003-08-27 2003-08-27 Embryo transfer catheters and assemblies
GB0320016.9 2003-08-27

Publications (1)

Publication Number Publication Date
WO2005021077A1 true WO2005021077A1 (en) 2005-03-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/003290 WO2005021077A1 (en) 2003-08-27 2004-07-29 Embryo transfer catheters and assemblies

Country Status (2)

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GB (1) GB0320016D0 (en)
WO (1) WO2005021077A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2000528C2 (en) * 2007-03-08 2008-09-09 Vu Medisch Ct Device suitable for the accurate and reproducible replacement of a fertilized egg (embryo) in the womb.
CN104224314A (en) * 2014-10-13 2014-12-24 湖南埃普特医疗器械有限公司 Guide catheter
CN106730246A (en) * 2017-01-16 2017-05-31 杭州唯强医疗科技有限公司 It is adapted to the adjustable bent catheter of left-handed operation
RU185028U1 (en) * 2018-05-10 2018-11-19 Денис Васильевич Огородников Embryo Transfer Device
RU187500U1 (en) * 2018-10-03 2019-03-11 Денис Васильевич Огородников Embryo Transplant Tool

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006494A1 (en) * 1993-09-03 1995-03-09 Intelliwire, Inc. Device with adjustable stiffness and bend location
WO2001023030A1 (en) * 1999-09-24 2001-04-05 Omnisonics Medical Technologies, Inc. Steerable catheter device
US6234958B1 (en) * 1998-11-30 2001-05-22 Medical Access Systems, Llc Medical device introduction system including medical introducer having a plurality of access ports and methods of performing medical procedures with same
US20020156346A1 (en) * 2001-01-12 2002-10-24 Kamrava Michael M. Endoscopic devices and method of use
US20030097080A1 (en) * 2001-11-22 2003-05-22 Masayoshi Esashi Active guide wire and method of making the same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006494A1 (en) * 1993-09-03 1995-03-09 Intelliwire, Inc. Device with adjustable stiffness and bend location
US6234958B1 (en) * 1998-11-30 2001-05-22 Medical Access Systems, Llc Medical device introduction system including medical introducer having a plurality of access ports and methods of performing medical procedures with same
WO2001023030A1 (en) * 1999-09-24 2001-04-05 Omnisonics Medical Technologies, Inc. Steerable catheter device
US20020156346A1 (en) * 2001-01-12 2002-10-24 Kamrava Michael M. Endoscopic devices and method of use
US20030097080A1 (en) * 2001-11-22 2003-05-22 Masayoshi Esashi Active guide wire and method of making the same

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2000528C2 (en) * 2007-03-08 2008-09-09 Vu Medisch Ct Device suitable for the accurate and reproducible replacement of a fertilized egg (embryo) in the womb.
WO2008108642A1 (en) * 2007-03-08 2008-09-12 Vu Medisch Centrum Suitable apparatus for precisely and reproducibly transferring a fertilized egg-cell (embryo) to the uterus
CN104224314A (en) * 2014-10-13 2014-12-24 湖南埃普特医疗器械有限公司 Guide catheter
CN106730246A (en) * 2017-01-16 2017-05-31 杭州唯强医疗科技有限公司 It is adapted to the adjustable bent catheter of left-handed operation
WO2018130074A1 (en) * 2017-01-16 2018-07-19 杭州唯强医疗科技有限公司 Adjustable bend catheter suitable for left-hand operation
US20210338983A1 (en) * 2017-01-16 2021-11-04 Hangzhou Wei Qiang Medical Technology Co., Ltd Steerable catheter suitable for left-hand operation
US11819635B2 (en) 2017-01-16 2023-11-21 Hangzhou Wei Qiang Medical Technology Co., Ltd Steerable catheter suitable for left-hand operation
RU185028U1 (en) * 2018-05-10 2018-11-19 Денис Васильевич Огородников Embryo Transfer Device
RU187500U1 (en) * 2018-10-03 2019-03-11 Денис Васильевич Огородников Embryo Transplant Tool

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