WO2005047864A3 - Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules - Google Patents

Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules Download PDF

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Publication number
WO2005047864A3
WO2005047864A3 PCT/US2004/038485 US2004038485W WO2005047864A3 WO 2005047864 A3 WO2005047864 A3 WO 2005047864A3 US 2004038485 W US2004038485 W US 2004038485W WO 2005047864 A3 WO2005047864 A3 WO 2005047864A3
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WO
WIPO (PCT)
Prior art keywords
magnetic
methods
biological molecules
detecting biological
detector arrays
Prior art date
Application number
PCT/US2004/038485
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French (fr)
Other versions
WO2005047864A2 (en
WO2005047864A9 (en
Inventor
Shan X Wang
Robert L White
Chris D Webb
Guanxiong Li
Original Assignee
Univ Leland Stanford Junior
Shan X Wang
Robert L White
Chris D Webb
Guanxiong Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior, Shan X Wang, Robert L White, Chris D Webb, Guanxiong Li filed Critical Univ Leland Stanford Junior
Priority to DE602004030031T priority Critical patent/DE602004030031D1/en
Priority to JP2006540017A priority patent/JP5161459B2/en
Priority to EP04817832A priority patent/EP1687634B1/en
Publication of WO2005047864A2 publication Critical patent/WO2005047864A2/en
Publication of WO2005047864A9 publication Critical patent/WO2005047864A9/en
Publication of WO2005047864A3 publication Critical patent/WO2005047864A3/en

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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F10/00—Thin magnetic films, e.g. of one-domain structure
    • H01F10/32—Spin-exchange-coupled multilayers, e.g. nanostructured superlattices
    • H01F10/324—Exchange coupling of magnetic film pairs via a very thin non-magnetic spacer, e.g. by exchange with conduction electrons of the spacer
    • H01F10/3268—Exchange coupling of magnetic film pairs via a very thin non-magnetic spacer, e.g. by exchange with conduction electrons of the spacer the exchange coupling being asymmetric, e.g. by use of additional pinning, by using antiferromagnetic or ferromagnetic coupling interface, i.e. so-called spin-valve [SV] structure, e.g. NiFe/Cu/NiFe/FeMn
    • H01F10/3272—Exchange coupling of magnetic film pairs via a very thin non-magnetic spacer, e.g. by exchange with conduction electrons of the spacer the exchange coupling being asymmetric, e.g. by use of additional pinning, by using antiferromagnetic or ferromagnetic coupling interface, i.e. so-called spin-valve [SV] structure, e.g. NiFe/Cu/NiFe/FeMn by use of anti-parallel coupled [APC] ferromagnetic layers, e.g. artificial ferrimagnets [AFI], artificial [AAF] or synthetic [SAF] anti-ferromagnets
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    • B82—NANOTECHNOLOGY
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    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
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    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F10/00—Thin magnetic films, e.g. of one-domain structure
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    • H01F10/324—Exchange coupling of magnetic film pairs via a very thin non-magnetic spacer, e.g. by exchange with conduction electrons of the spacer
    • H01F10/3254—Exchange coupling of magnetic film pairs via a very thin non-magnetic spacer, e.g. by exchange with conduction electrons of the spacer the spacer being semiconducting or insulating, e.g. for spin tunnel junction [STJ]
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezo-electric or ink jet dispensers
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
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    • C40—COMBINATORIAL TECHNOLOGY
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    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
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    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
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    • C40—COMBINATORIAL TECHNOLOGY
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/10—Magnetic particle immunoreagent carriers the magnetic material being used to coat a pre-existing polymer particle but not being present in the particle core
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/00—Stock material or miscellaneous articles
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Abstract

Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
PCT/US2004/038485 2003-11-12 2004-11-12 Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules WO2005047864A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE602004030031T DE602004030031D1 (en) 2003-11-12 2004-11-12 MAGNETIC NANOPARTICLES, MAGNETIC DETECTOR ARRAYS, AND METHOD FOR USE THEREOF IN PROVING BIOLOGICAL MOLECULES
JP2006540017A JP5161459B2 (en) 2003-11-12 2004-11-12 Magnetic detector arrays and methods for their use in the detection of biological molecules
EP04817832A EP1687634B1 (en) 2003-11-12 2004-11-12 Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51937803P 2003-11-12 2003-11-12
US60/519,378 2003-11-12

Publications (3)

Publication Number Publication Date
WO2005047864A2 WO2005047864A2 (en) 2005-05-26
WO2005047864A9 WO2005047864A9 (en) 2005-07-21
WO2005047864A3 true WO2005047864A3 (en) 2005-09-29

Family

ID=34590402

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/038485 WO2005047864A2 (en) 2003-11-12 2004-11-12 Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules

Country Status (5)

Country Link
US (3) US7906345B2 (en)
EP (1) EP1687634B1 (en)
JP (3) JP5161459B2 (en)
DE (1) DE602004030031D1 (en)
WO (1) WO2005047864A2 (en)

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