WO2005090302A3 - Palladium catalyzed indolization of 2-bromo or chloroanilines - Google Patents
Palladium catalyzed indolization of 2-bromo or chloroanilines Download PDFInfo
- Publication number
- WO2005090302A3 WO2005090302A3 PCT/US2005/008620 US2005008620W WO2005090302A3 WO 2005090302 A3 WO2005090302 A3 WO 2005090302A3 US 2005008620 W US2005008620 W US 2005008620W WO 2005090302 A3 WO2005090302 A3 WO 2005090302A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chloroanilines
- bromo
- palladium catalyzed
- formula
- indolization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05725655A EP1727796A2 (en) | 2004-03-16 | 2005-03-14 | Palladium catalyzed indolization of 2-bromo or chloroanilines |
JP2007504038A JP4879160B2 (en) | 2004-03-16 | 2005-03-14 | Palladium-catalyzed indolization of 2-bromo or chloroaniline |
CA2558051A CA2558051C (en) | 2004-03-16 | 2005-03-14 | Palladium catalyzed indolization of 2-bromo or chloroanilines |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55359604P | 2004-03-16 | 2004-03-16 | |
US60/553,596 | 2004-03-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005090302A2 WO2005090302A2 (en) | 2005-09-29 |
WO2005090302A3 true WO2005090302A3 (en) | 2006-07-13 |
Family
ID=34994422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/008620 WO2005090302A2 (en) | 2004-03-16 | 2005-03-14 | Palladium catalyzed indolization of 2-bromo or chloroanilines |
Country Status (5)
Country | Link |
---|---|
US (2) | US7126009B2 (en) |
EP (1) | EP1727796A2 (en) |
JP (1) | JP4879160B2 (en) |
CA (1) | CA2558051C (en) |
WO (1) | WO2005090302A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CN101648944A (en) * | 2004-02-20 | 2010-02-17 | 贝林格尔.英格海姆国际有限公司 | Viral polymerase inhibitors |
AU2006204917A1 (en) * | 2005-01-14 | 2006-07-20 | Smithkline Beecham Corporation | Indole derivatives for treating viral infections |
KR20070112165A (en) * | 2005-02-11 | 2007-11-22 | 베링거 인겔하임 인터내셔날 게엠베하 | Process for preparing 2,3-disubstituted indoles |
JP5015154B2 (en) * | 2005-08-12 | 2012-08-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Viral polymerase inhibitor |
AU2006279537A1 (en) * | 2005-08-15 | 2007-02-22 | Irm Llc | Compounds and compositions as TPO mimetics |
US20080051384A1 (en) * | 2006-07-14 | 2008-02-28 | Genelabs Technologies, Inc. | Antiviral agents |
AR072297A1 (en) * | 2008-06-27 | 2010-08-18 | Novartis Ag | DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE. |
CN113527173B (en) * | 2021-08-30 | 2022-12-16 | 河南师范大学 | Method for synthesizing indole terpene analogues through Heck tandem reaction |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB427251A (en) * | 1933-08-18 | 1935-04-18 | Ici Ltd | Manufacture of intermediates for dyes |
US3905999A (en) * | 1972-06-20 | 1975-09-16 | Eastman Kodak Co | Synthesis of 2,3-substituted indoles |
KR950701317A (en) * | 1992-05-08 | 1995-03-23 | 오오쓰까 아끼히꼬 | Indole Derivative |
US6028111A (en) * | 1996-03-08 | 2000-02-22 | Oxigene, Inc. | Compositions and use of benzamides and nicotinamides as anti-inflammatory agents |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
-
2005
- 2005-03-14 JP JP2007504038A patent/JP4879160B2/en not_active Expired - Fee Related
- 2005-03-14 WO PCT/US2005/008620 patent/WO2005090302A2/en not_active Application Discontinuation
- 2005-03-14 US US11/079,636 patent/US7126009B2/en active Active
- 2005-03-14 EP EP05725655A patent/EP1727796A2/en not_active Withdrawn
- 2005-03-14 CA CA2558051A patent/CA2558051C/en not_active Expired - Fee Related
-
2006
- 2006-08-29 US US11/468,185 patent/US7408076B2/en active Active
Non-Patent Citations (8)
Title |
---|
DATABASE ZREGISTRY [online] 12 December 1987 (1987-12-12), XP002377297, retrieved from STN * |
DATABASE ZREGISTRY [online] 16 November 1984 (1984-11-16), XP002377298, retrieved from STN * |
DATABASE ZREGISTRY [online] 16 November 1984 (1984-11-16), XP002377299, retrieved from STN * |
F. MAASSARANI, M. PFEFFER, J. SPENCER, E. WEHMAN, JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol. 466, 1994, pages 265 - 271, XP002375385 * |
FIDA MAASSARANI, MICHEL PFEFFER, GUY LE BORGNE, ORGANOMETALLICS, vol. 6, 1987, pages 2029 - 2043, XP002375383 * |
FIDA MAASSARANI, MICHEL PFEFFER, GUY LE BORGNE, ORGANOMETALLICS, vol. 6, 1987, pages 2043 - 2053, XP002375384 * |
ORGANIC LETTERS, vol. 6, no. 22, 2004, pages 4129 - 4132, XP002375386 * |
R. C. LAROCK, E. K. YUM, M. D. REFVIK, J. ORG. CHEM., vol. 63, 1998, pages 7652 - 7662, XP002375382 * |
Also Published As
Publication number | Publication date |
---|---|
EP1727796A2 (en) | 2006-12-06 |
WO2005090302A2 (en) | 2005-09-29 |
CA2558051A1 (en) | 2005-09-29 |
JP2007529538A (en) | 2007-10-25 |
US20060287376A1 (en) | 2006-12-21 |
US7408076B2 (en) | 2008-08-05 |
CA2558051C (en) | 2013-03-12 |
JP4879160B2 (en) | 2012-02-22 |
US20050209465A1 (en) | 2005-09-22 |
US7126009B2 (en) | 2006-10-24 |
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