WO2005092308A3 - Neural tourniquet - Google Patents

Neural tourniquet Download PDF

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Publication number
WO2005092308A3
WO2005092308A3 PCT/US2005/009954 US2005009954W WO2005092308A3 WO 2005092308 A3 WO2005092308 A3 WO 2005092308A3 US 2005009954 W US2005009954 W US 2005009954W WO 2005092308 A3 WO2005092308 A3 WO 2005092308A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
cholinergic
inflammatory pathway
tourniquet
neural
Prior art date
Application number
PCT/US2005/009954
Other languages
French (fr)
Other versions
WO2005092308A2 (en
Inventor
Kevin J Tracey
Carol A Amella
Christopher Czura
Original Assignee
Long Island Jewish Res Inst
Kevin J Tracey
Carol A Amella
Christopher Czura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Long Island Jewish Res Inst, Kevin J Tracey, Carol A Amella, Christopher Czura filed Critical Long Island Jewish Res Inst
Priority to JP2007505209A priority Critical patent/JP2007530586A/en
Priority to EP05755668A priority patent/EP1734941A2/en
Priority to AU2005225458A priority patent/AU2005225458B2/en
Priority to CA002560756A priority patent/CA2560756A1/en
Publication of WO2005092308A2 publication Critical patent/WO2005092308A2/en
Publication of WO2005092308A3 publication Critical patent/WO2005092308A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4747Quinolines; Isoquinolines spiro-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

Disclosed is a method of reducing bleed time in a subject by activation of the cholinergic anti-inflammatory pathway in said subject. The cholinergic anti-inflammatory pathway can be activated by direct or indirect stimulation of the vagus nerve. The cholinergic anti-inflammatory pathway can also be activated by administering an effective amount of cholinergic agonist acetylcholinesterase inhibitor to the subject.
PCT/US2005/009954 2004-03-25 2005-03-24 Neural tourniquet WO2005092308A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2007505209A JP2007530586A (en) 2004-03-25 2005-03-24 Nervous hemostasis
EP05755668A EP1734941A2 (en) 2004-03-25 2005-03-24 Neural tourniquet
AU2005225458A AU2005225458B2 (en) 2004-03-25 2005-03-24 Neural tourniquet
CA002560756A CA2560756A1 (en) 2004-03-25 2005-03-24 Methods and devices for reducing bleed time using vagus nerve stimulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55609604P 2004-03-25 2004-03-25
US60/556,096 2004-03-25

Publications (2)

Publication Number Publication Date
WO2005092308A2 WO2005092308A2 (en) 2005-10-06
WO2005092308A3 true WO2005092308A3 (en) 2005-12-01

Family

ID=34971547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/009954 WO2005092308A2 (en) 2004-03-25 2005-03-24 Neural tourniquet

Country Status (6)

Country Link
US (1) US8729129B2 (en)
EP (1) EP1734941A2 (en)
JP (1) JP2007530586A (en)
AU (1) AU2005225458B2 (en)
CA (1) CA2560756A1 (en)
WO (1) WO2005092308A2 (en)

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