WO2005115535A3 - Treating a tumor or the like with electric fields at different frequencies - Google Patents

Treating a tumor or the like with electric fields at different frequencies Download PDF

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Publication number
WO2005115535A3
WO2005115535A3 PCT/IB2005/002410 IB2005002410W WO2005115535A3 WO 2005115535 A3 WO2005115535 A3 WO 2005115535A3 IB 2005002410 W IB2005002410 W IB 2005002410W WO 2005115535 A3 WO2005115535 A3 WO 2005115535A3
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WO
WIPO (PCT)
Prior art keywords
cells
field
tumor
electric fields
treating
Prior art date
Application number
PCT/IB2005/002410
Other languages
French (fr)
Other versions
WO2005115535A2 (en
Inventor
Yoram Palti
Original Assignee
Staden Ltd
Palti Yoram Prof
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Staden Ltd, Palti Yoram Prof filed Critical Staden Ltd
Priority to EP05767642A priority Critical patent/EP1740268A2/en
Priority to JP2007509012A priority patent/JP4750784B2/en
Priority to CN200580018206.6A priority patent/CN1976738B/en
Priority to CA2563817A priority patent/CA2563817C/en
Publication of WO2005115535A2 publication Critical patent/WO2005115535A2/en
Publication of WO2005115535A3 publication Critical patent/WO2005115535A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Abstract

Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Improved results may be achieved by using a field with two or more frequencies.
PCT/IB2005/002410 2004-04-23 2005-04-21 Treating a tumor or the like with electric fields at different frequencies WO2005115535A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05767642A EP1740268A2 (en) 2004-04-23 2005-04-21 Treating a tumor or the like with electric fields at different frequencies
JP2007509012A JP4750784B2 (en) 2004-04-23 2005-04-21 Treatment of tumors by electric fields of different frequencies
CN200580018206.6A CN1976738B (en) 2004-04-23 2005-04-21 Treating a tumor or the like with an electric field
CA2563817A CA2563817C (en) 2004-04-23 2005-04-21 Treating a tumor or the like with electric fields at different frequencies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56506504P 2004-04-23 2004-04-23
US60/565,065 2004-04-23

Publications (2)

Publication Number Publication Date
WO2005115535A2 WO2005115535A2 (en) 2005-12-08
WO2005115535A3 true WO2005115535A3 (en) 2006-04-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002410 WO2005115535A2 (en) 2004-04-23 2005-04-21 Treating a tumor or the like with electric fields at different frequencies

Country Status (6)

Country Link
US (5) US7565205B2 (en)
EP (1) EP1740268A2 (en)
JP (2) JP4750784B2 (en)
CN (1) CN1976738B (en)
CA (1) CA2563817C (en)
WO (1) WO2005115535A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850422B2 (en) 2019-04-23 2023-12-26 Boston Scientific Scimed, Inc. Electrodes for electrical stimulation to treat cancer

Families Citing this family (256)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6104959A (en) 1997-07-31 2000-08-15 Microwave Medical Corp. Method and apparatus for treating subcutaneous histological features
AU3399801A (en) 2000-02-17 2001-08-27 Yoram Palti Method and apparatus for destroying dividing cells
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US7136699B2 (en) * 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US7089054B2 (en) * 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US6868289B2 (en) * 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US8447395B2 (en) * 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
DE10260149A1 (en) 2002-12-20 2004-07-01 BSH Bosch und Siemens Hausgeräte GmbH Device for determining the conductivity of laundry, clothes dryer and method for preventing layer formation on electrodes
TW200416015A (en) * 2003-02-17 2004-09-01 Wei-Gung Wang Device for selectively generating hydrogen ions in an aqueous solution
US7775087B2 (en) * 2004-03-16 2010-08-17 Northwestern University Microchannel forming method and nanotipped dispensing device having a microchannel
WO2005115535A2 (en) * 2004-04-23 2005-12-08 Novocure Ltd. Treating a tumor or the like with electric fields at different frequencies
US20060047328A1 (en) * 2004-08-31 2006-03-02 Patrick Murphy Multi-frequency electrical field generator and use thereof
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
DK2345451T3 (en) * 2004-12-07 2018-04-23 Novocure Ltd Electrodes for applying an electric field in vivo over an extended period of time
JP5559460B2 (en) * 2004-12-27 2014-07-23 スタンデン・リミテッド Method for treating tumors or the like using electric fields of different orientations
US7717853B2 (en) * 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
US20110160621A1 (en) * 2005-06-24 2011-06-30 Henry Nita Methods and apparatus for dissolving intracranial blood clots
JP2009520509A (en) * 2005-10-03 2009-05-28 ノヴォキュアー・リミテッド Electric field optimization properties to increase the effect of electric fields in proliferating cells
US8874227B2 (en) 2009-03-20 2014-10-28 ElectroCore, LLC Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
US7680543B2 (en) * 2006-09-14 2010-03-16 Lazure Technologies, Llc Tissue ablation and removal
DK2167194T3 (en) * 2007-03-06 2017-06-19 Novocure Ltd TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY
US9149331B2 (en) 2007-04-19 2015-10-06 Miramar Labs, Inc. Methods and apparatus for reducing sweat production
WO2008131306A1 (en) 2007-04-19 2008-10-30 The Foundry, Inc. Systems and methods for creating an effect using microwave energy to specified tissue
US20100114086A1 (en) 2007-04-19 2010-05-06 Deem Mark E Methods, devices, and systems for non-invasive delivery of microwave therapy
RU2523620C2 (en) 2007-04-19 2014-07-20 Мирамар Лэбс,Инк. Systems and methods for generating exposure on target tissue with using microwave energy
WO2009022225A1 (en) * 2007-08-14 2009-02-19 Novocure Ltd. Treating parasites with electric fields
US20090076500A1 (en) * 2007-09-14 2009-03-19 Lazure Technologies, Llc Multi-tine probe and treatment by activation of opposing tines
WO2009036457A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc Multi-layer electrode ablation probe and related methods
WO2009036472A1 (en) * 2007-09-14 2009-03-19 Lazure Technologies, Llc Prostate cancer ablation
BRPI0820706B8 (en) 2007-12-12 2021-06-22 Miramar Labs Inc disposable medical device for use with an applicator
EP2231274B1 (en) 2007-12-12 2014-03-12 Miramar Labs, Inc. System and apparatus for the noninvasive treatment of tissue using microwave energy
EP2271276A4 (en) 2008-04-17 2013-01-23 Miramar Labs Inc Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US20100100093A1 (en) * 2008-09-16 2010-04-22 Lazure Technologies, Llc. System and method for controlled tissue heating for destruction of cancerous cells
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8974445B2 (en) 2009-01-09 2015-03-10 Recor Medical, Inc. Methods and apparatus for treatment of cardiac valve insufficiency
US8728139B2 (en) 2009-04-16 2014-05-20 Lazure Technologies, Llc System and method for energy delivery to a tissue using an electrode array
CN101628155B (en) * 2009-08-14 2012-04-18 鞍山市嘉惠广播电子技术有限公司 Ultrahigh frequency tumor treatment equipment
US9375223B2 (en) 2009-10-06 2016-06-28 Cardioprolific Inc. Methods and devices for endovascular therapy
US20110209723A1 (en) * 2010-03-01 2011-09-01 David Hunt Sullivan Methods Of Treating Clothing And Textiles And Articles Treated Thereby
US9526911B1 (en) 2010-04-27 2016-12-27 Lazure Scientific, Inc. Immune mediated cancer cell destruction, systems and methods
US8719720B2 (en) 2010-09-24 2014-05-06 Honeywell International Inc. Economizer controller plug and play system recognition with automatic user interface population
CN107007348B (en) 2010-10-25 2019-05-31 美敦力Af卢森堡有限责任公司 For the estimation of nerve modulation treatment and device, the system and method for feedback
US8684901B1 (en) 2010-11-22 2014-04-01 Jacob Zabara Electromagnetic radiation treatment for cancer and pathological genetic regulations
US9233257B1 (en) 2010-11-22 2016-01-12 Jacob Zabara Electromagnetic radiation treatment
WO2013105987A2 (en) 2011-02-15 2013-07-18 Hemosonics, Llc Characterization of blood hemostasis and oxygen transport parameters
US9675814B2 (en) 2011-05-09 2017-06-13 Innovolink, Llc Apparatus and method for obtaining a substantially constant current across a treatment region
US9901742B2 (en) * 2011-05-09 2018-02-27 Innovolink, Llc Apparatus and method for heating a treatment region with an alternating electric field
US20120290049A1 (en) * 2011-05-09 2012-11-15 Michel Marc Apparatus and Method for Providing a Substantially Constant Voltage Between Electrodes Extending Across a Treatment Region
US9956028B2 (en) 2011-05-09 2018-05-01 Innovolink, Llc Apparatus and method for heating biological targets
US9901387B2 (en) 2011-05-09 2018-02-27 Innovolink, Llc Apparatus and method for heating adipose cells
WO2012154736A1 (en) * 2011-05-09 2012-11-15 Innovolink, Llc Apparatus and method for heating a treatment region with an alternating electric field
US9314301B2 (en) 2011-08-01 2016-04-19 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
JP2014522714A (en) 2011-08-08 2014-09-08 ルース，リチャード，ビー． Method and apparatus for treating cancer
US9486625B2 (en) 2011-08-08 2016-11-08 Medamp Electronics, Llc Method for treating benign prostate hyperplasia
RU2644933C2 (en) 2012-03-08 2018-02-14 Медтроник Аф Люксембург Сарл Biomarker samples selection as part of devices for neuromodulation and relevant systems and methods
AU2013230781B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
WO2014039569A2 (en) 2012-09-05 2014-03-13 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US10080907B1 (en) 2012-10-26 2018-09-25 University Of South Florida Systems and methods for controlling the spatial distribution of an electromagnetic field
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
WO2015013502A2 (en) 2013-07-24 2015-01-29 Miramar Labs, Inc. Apparatus and methods for the treatment of tissue using microwave energy
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US20190117963A1 (en) * 2014-07-25 2019-04-25 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
US9833617B2 (en) * 2014-07-25 2017-12-05 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
JP2018511362A (en) 2015-03-09 2018-04-26 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Iontophoresis device, apparatus and method
US9726647B2 (en) 2015-03-17 2017-08-08 Hemosonics, Llc Determining mechanical properties via ultrasound-induced resonance
US9910453B2 (en) 2015-09-25 2018-03-06 Novocure Limited High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US11571567B2 (en) * 2016-01-05 2023-02-07 Biosensor Laboratories Inc. Iontophoresis device for drug delivery and method for manufacturing the same
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
EP3478360B1 (en) 2016-06-30 2024-04-10 Novocure GmbH Arrays for longitudinal delivery of ttfields to a body
NZ750440A (en) 2016-08-18 2023-03-31 Novocure Gmbh Temperature measurement in arrays for delivering ttfields
CN110035794A (en) 2016-11-24 2019-07-19 公立大学法人横浜市立大学 Cancer therapeutic device
BR112019012033A2 (en) 2016-12-13 2020-03-03 Novocure Gmbh TREATMENT OF PATIENTS WITH TTFIELDS WITH ELECTRODE POSITIONS OPTIMIZED WITH THE USE OF DEFORMABLE GABBARITES
CN110178029B (en) * 2017-01-19 2021-11-16 诺沃库勒有限责任公司 System for observing cell cultures under a microscope while applying TTfields
CN106823125A (en) * 2017-03-24 2017-06-13 长沙利星医药科技开发有限公司 A kind of device of use amplitude modulation electric-field enhancing curative effect of medication
CN107281635B (en) * 2017-07-26 2024-01-16 江苏海莱新创医疗科技有限公司 Electrode physiotherapy device and electrode positioning method
US11338135B2 (en) * 2017-10-23 2022-05-24 Cardiac Pacemakers, Inc. Medical devices for cancer therapy with electric field shaping elements
US20190117969A1 (en) * 2017-10-23 2019-04-25 Cardiac Pacemakers, Inc. Medical devices for treatment of cancer with electric fields
US20190117970A1 (en) 2017-10-23 2019-04-25 Cardiac Pacemakers, Inc. Electric field shaping leads for treatment of cancer
US20220125510A1 (en) * 2020-10-26 2022-04-28 Evanesc Therapeutics, Inc. Apparatus for application of evanescent waves to biological tissues
CN111601641B (en) * 2017-11-07 2022-06-07 伊凡斯克医疗公司 Device for treating tumors by evanescent waves
JP2021508533A (en) 2017-12-26 2021-03-11 ギャラリー，インコーポレイテッド Optimizing energy delivery for a variety of applications
CN110115803A (en) * 2018-02-07 2019-08-13 张建义 A kind of power supply device can be used for biomedical research and auxiliary electrode Array Design
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
US11058886B1 (en) 2018-04-05 2021-07-13 Evanesc Therapeutics, Inc. Method of polarization control of evanescent waves for treating tumors
US11298422B2 (en) 2018-04-09 2022-04-12 Novocure Gmbh Treating tumors with TTFields and an aurora kinase inhibitor
PL3775956T3 (en) 2018-04-10 2022-10-10 Novocure Gmbh Low frequency (< 1 mhz) ac conductivity estimates derived from two mri images having different repetition times
JP7152709B2 (en) 2018-05-23 2022-10-13 株式会社リコー Power supply and magnetic field generation system
EP3900777A1 (en) 2018-07-03 2021-10-27 Edwin Chang Using alternating electric fields to increase cell membrane permeability
BR112020025692A2 (en) 2018-07-10 2021-03-16 Novocure Gmbh INHIBITION OF VIRAL INFECTION USING ALTERNATE ELECTRIC FIELDS
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
WO2020016840A1 (en) 2018-07-18 2020-01-23 Novocure Gmbh Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields)
HUE059062T2 (en) 2018-08-23 2022-10-28 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier
US11160977B2 (en) 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
EP3846894A1 (en) 2018-09-07 2021-07-14 Novocure GmbH Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
PL3984590T3 (en) 2018-10-15 2023-05-02 Novocure Gmbh Generating tumor treating fields (ttfields) with high uniformity throughout the brain
CN113164525A (en) 2018-10-23 2021-07-23 利兰·斯坦福青年大学托管委员会 Use of alternating electric fields for prevention and treatment of teratoma formation in stem cell-based therapies
WO2020084596A1 (en) 2018-10-25 2020-04-30 Zeev Bomzon Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy
CA3117907A1 (en) * 2018-11-01 2020-05-07 Loyalty Based Innovations, LLC Apparatus and method for treating multiple tumors in patients with metastatic disease by electric fields
EP3883642B1 (en) * 2018-11-19 2024-02-21 Novocure GmbH Arrays for delivering tumor treating fields (ttfields) with selectively addressable sub-elements
EP3886978B1 (en) 2018-11-29 2024-04-03 Novocure GmbH Enhanced-flexibility transducer arrays for delivering ttfields (tumor treating fields)
JP2019093146A (en) * 2018-12-13 2019-06-20 パルティ、ヨーラム Apparatus and methods for treating tumor with alternating electric field and for selecting treatment frequency based on estimated cell size
WO2020144582A1 (en) 2019-01-08 2020-07-16 Novocure Gmbh Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
US11027143B2 (en) 2020-02-06 2021-06-08 Vivek K. Sharma System and methods for treating cancer cells with alternating polarity magnetic fields
US11344740B2 (en) 2019-02-07 2022-05-31 Asha Medical, Inc. System and methods for treating cancer cells with alternating polarity magnetic fields
JP2022519782A (en) 2019-02-07 2022-03-24 ヴィヴェーク・ケー・シャルマ Systems and methods for treating cancer cells with alternating polar magnetic fields
CN113573774A (en) 2019-02-26 2021-10-29 诺沃库勒有限责任公司 Determining frequency of TTfield therapy based on electrical properties of targeted cancer cells
WO2020174429A1 (en) 2019-02-27 2020-09-03 Yoram Wasserman Delivering tumor treating fields (ttfields) using implantable transducer arrays
WO2020201967A1 (en) 2019-03-29 2020-10-08 Novocure Gmbh Methods for restoring sensitivity to ttfields in ttfields-resistant cancer cells with ptger3 inhibitors
PL3960232T3 (en) 2019-04-17 2023-05-15 Novocure Gmbh Uploading data from an isolated system without compromising isolation
CN110038219A (en) * 2019-04-18 2019-07-23 马冲 A kind of apparats for treating tumor
CN113727753A (en) 2019-04-22 2021-11-30 波士顿科学国际有限公司 Electrical stimulation device for cancer treatment
JP7410176B2 (en) * 2019-04-22 2024-01-09 ボストン サイエンティフィック サイムド，インコーポレイテッド System for delivering electrical stimulation to treat cancer
EP3958957A1 (en) * 2019-04-22 2022-03-02 Boston Scientific Scimed, Inc. Combination electrical and chemotherapeutic treatment of cancer
EP3958960A1 (en) * 2019-04-23 2022-03-02 Boston Scientific Scimed Inc. Electrical stimulation with thermal treatment or thermal monitoring
US11607542B2 (en) 2019-04-23 2023-03-21 Boston Scientific Scimed, Inc. Electrical stimulation for cancer treatment with internal and external electrodes
US11620789B2 (en) 2019-05-03 2023-04-04 Novocure Gmbh Methods, systems, and apparatuses for managing transducer array placement
CN110051933A (en) * 2019-05-31 2019-07-26 北京康源嘉成生物科技有限公司 A kind of wearable device inhibiting pathological tissues fast-growth using electromagnetic wave
JP2022542400A (en) * 2019-07-31 2022-10-03 ノボキュア ゲーエムベーハー Application of tumor therapeutic electric fields (TT fields) by electrodes implanted in skull implants
JP2022545344A (en) * 2019-08-05 2022-10-27 ノボキュア ゲーエムベーハー sensitize cancer cells to tumor therapeutic fields (TT fields) by inhibiting IL11 activity
US11890467B2 (en) 2019-08-30 2024-02-06 Novocure Gmbh Delivering tumor treating fields (TTFields) to the neck
CA3152250A1 (en) 2019-09-10 2021-03-18 Novocure Gmbh A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells
US20240061398A1 (en) 2019-10-07 2024-02-22 Novocure Gmbh Methods, systems, and apparatuses for guiding transducer array placement
WO2021092402A1 (en) 2019-11-08 2021-05-14 Novocure Gmbh Perforated hydrogel configurations and methods of production and use thereof
WO2021102120A1 (en) 2019-11-21 2021-05-27 Carlson Kristen W Implantable arrays for providing tumor treating fields
WO2021111186A1 (en) 2019-12-02 2021-06-10 Novocure Gmbh Methods and apparatuses for optimizing transducer array placement
JP2023505578A (en) 2019-12-11 2023-02-09 ノボキュア ゲーエムベーハー Method of changing electrical impedance to an alternating electric field
IL293418A (en) 2019-12-11 2022-07-01 Novocure Gmbh Compositions and methods for imaging a cell
CA3163262A1 (en) 2019-12-11 2021-06-17 Novocure Gmbh Compositions and methods of altering the electric impedance to an alternating electric field
US20210177492A1 (en) * 2019-12-16 2021-06-17 Loyalty Based Innovations, LLC Apparatus and method for optimizing and adapting treatment of multiple tumors in patients with metastatic disease by electric field
CN115515419B (en) 2019-12-20 2024-03-29 诺沃库勒有限责任公司 Rotary joint assembly for actively limiting cable torsion and systems and methods using same
WO2021123914A1 (en) 2019-12-20 2021-06-24 Novocure Gmbh Treatment assembly for providing tumor treating fields to animal test subjects
US11464203B2 (en) 2019-12-20 2022-10-11 Novocure Gmbh Cage assembly for animal test subjects
US20210199640A1 (en) 2019-12-26 2021-07-01 The Board of Trustees of the Leland Stanford Junior Unviersity Methods of Normalizing Aberrant Glycolytic Metabolism in Cancer Cells
JP2023510203A (en) 2019-12-31 2023-03-13 ノボキュア ゲーエムベーハー High-voltage, high-efficiency sine wave generator that prevents spikes during amplitude adjustment and channel switching
US20230147250A1 (en) 2019-12-31 2023-05-11 Novocure Gmbh Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy
WO2021136971A1 (en) 2019-12-31 2021-07-08 Novocure Gmbh Methods, systems, and apparatuses for fast approximation of electric field distribution
EP4105890A1 (en) 2019-12-31 2022-12-21 Novocure GmbH Methods, systems, and apparatuses for image segmentation
US20210196967A1 (en) 2019-12-31 2021-07-01 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
DK4074367T3 (en) 2019-12-31 2023-05-22 Novocure Gmbh ARRAYS FOR DELIVERY OF TUMOR TREATMENT FIELDS (TT FIELDS) WITH INDIVIDUALLY AVAILABLE ELECTRODE ELEMENTS AND TEMPERATURE SENSORS
WO2021136964A1 (en) 2019-12-31 2021-07-08 Novocure Gmbh Methods, systems, and apparatuses for associating dielectric properties with a patient model
TW202140096A (en) 2020-01-22 2021-11-01 瑞士商諾沃庫勒有限責任公司 Assemblies containing two conductive gel compositions and methods of production and use thereof
CN115515674A (en) 2020-02-24 2022-12-23 波士顿科学国际有限公司 Systems and methods for treating pancreatic cancer
WO2021198864A1 (en) 2020-03-30 2021-10-07 Novocure Gmbh Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases
US20210299439A1 (en) 2020-03-31 2021-09-30 Novocure Gmb Methods, systems, and apparatuses for guiding transducer placements for tumor treating fields
KR102644003B1 (en) * 2020-04-01 2024-03-07 한국전자통신연구원 Cancer treatment device
MX2022010015A (en) 2020-04-24 2022-09-05 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier.
TW202200232A (en) 2020-05-06 2022-01-01 瑞士商諾沃庫勒有限責任公司 Conductive pad generating tumor treating field and methods of production and use thereof
US11850421B2 (en) 2020-05-08 2023-12-26 Novocure Gmbh Compositions and methods of applying alternating electric fields to pluripotent stem cells
US11839771B2 (en) 2020-06-02 2023-12-12 Novocure Gmbh Implantable arrays for providing tumor treating fields
WO2021257967A1 (en) 2020-06-19 2021-12-23 The Methodist Hospital Dba Houston Methodist Hospital Method and apparatus for oncomagnetic treatment
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
WO2022003519A2 (en) 2020-06-29 2022-01-06 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
CA3178883A1 (en) 2020-06-30 2022-01-06 Novocure Gmbh Flexible transducer arrays with a polymer insulating layer for applying tumor treating fields (ttfields)
CN116390760A (en) 2020-08-03 2023-07-04 诺沃库勒有限责任公司 Compositions and methods for increasing sensitivity of cancer cells to alternating electric fields
EP4213933A1 (en) 2020-09-18 2023-07-26 Novocure Gmbh Methods and compositions for treating coronavirus
US20220096853A1 (en) 2020-09-30 2022-03-31 Novocure Gmbh Methods and systems for transducer array placement and skin surface condition avoidance
EP4268743A3 (en) 2020-09-30 2024-01-03 Novocure GmbH Implantable arrays for providing tumor treating fields
US20220096829A1 (en) 2020-09-30 2022-03-31 Novocure Gmbh Method and apparatus for delivering tumor treating fields to a torso, and method for determining locations for transducers to deliver tumor treating fields
TWI815047B (en) * 2020-10-16 2023-09-11 瑞士商諾沃庫勒有限責任公司 Methods for reducing viability of cancer cells by activation of the sting pathway with ttfields
TWI805954B (en) * 2020-10-16 2023-06-21 瑞士商諾沃庫勒有限責任公司 Applying tumor treating fields (ttfields) via electrodes embedded into skull implants
US20220148171A1 (en) 2020-11-06 2022-05-12 Novocure Gmbh Methods and apparatuses for determining transducer locations to generate tumor treating fields
CA3202404A1 (en) 2020-11-25 2022-06-02 Novocure Gmbh Increasing the efficacy of tumor treating fields (ttfields) by applying the ttfields at peak intensity less than half the time
DE102020133165B4 (en) * 2020-12-11 2024-03-07 Tdk Electronics Ag Ceramic electrode, assembly with the ceramic electrode, arrangement with the ceramic electrode and method for producing a ceramic electrode
WO2022130183A2 (en) 2020-12-17 2022-06-23 Novocure Gmbh Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields)
EP4282465A3 (en) 2020-12-21 2024-02-28 Novocure GmbH Optimization of composite electrode
JP2024502295A (en) 2020-12-24 2024-01-18 ノボキュア ゲーエムベーハー Methods and compositions for using alternating electric fields in gene therapy
WO2022147153A1 (en) 2020-12-30 2022-07-07 Novocure Gmbh Amplitude modulation for tumor treating fields
US20220203110A1 (en) 2020-12-30 2022-06-30 Novocure Gmbh Method and apparatus for determining transducer locations to generate tumor treating fields
EP4260277A1 (en) 2021-01-22 2023-10-18 Novocure Gmbh Methods, systems, and apparatuses for medical image enhancement to optimize transducer array placement
US20220241603A1 (en) 2021-02-03 2022-08-04 Novocure Gmbh Varying Parameters of Tumor Treating Fields (TTFields) Treatment to Overcome Treatment Resistance
KR20230150317A (en) 2021-03-02 2023-10-30 노보큐어 게엠베하 Method and apparatus for visualization of tumor segmentation
WO2022190067A1 (en) 2021-03-12 2022-09-15 Novocure Gmbh Compositions and methods for using alternating electric fields to disrupt nanoparticles
CN116981497A (en) 2021-03-12 2023-10-31 诺沃库勒有限责任公司 Methods for treating diseases by biasing macrophage phenotype with alternating electric field
JP2024514045A (en) 2021-03-12 2024-03-28 ノボキュア ゲーエムベーハー Electrode arrays and methods of manufacturing and using them
EP4271466A2 (en) 2021-03-18 2023-11-08 Novocure Gmbh Constructing a 3d phantom with liquid hydrogel
WO2022200964A1 (en) 2021-03-23 2022-09-29 Novocure Gmbh Transducer apparatuses for delivering tumor treating fields to a subject's body
WO2022201060A1 (en) 2021-03-23 2022-09-29 Novocure Gmbh Method and apparatus for detecting and responding to changes in subjects
JP2024511868A (en) 2021-03-31 2024-03-15 ノボキュア ゲーエムベーハー Carrier for elements of tumor treatment electric field delivery system and systems and methods using the carrier
US20220323753A1 (en) 2021-04-08 2022-10-13 Novocure Gmbh Methods of Treating Neurodegenerative Disorders with Alternating Electric Fields
EP4346998A1 (en) 2021-06-01 2024-04-10 Novocure GmbH Compositions and methods for treating with a combination of alternating electric fields and trastuzumab
CN117580614A (en) 2021-06-30 2024-02-20 诺沃库勒有限责任公司 Compositions and methods for increasing sensitivity of cancer cells to alternating electric fields
WO2023275648A1 (en) 2021-06-30 2023-01-05 Novocure Gmbh Compositions and methods for using alternating electric fields to disrupt lipid capsules
US20230024216A1 (en) 2021-07-21 2023-01-26 Novocure Gmbh Conductive pad generating tumor treating field and methods of production and use thereof
WO2023017489A1 (en) 2021-08-12 2023-02-16 Novocure Gmbh Methods and apparatuses for delivering tumor treating fields to a subject's body for near-surface tumors
WO2023017491A1 (en) 2021-08-12 2023-02-16 Novocure Gmbh Apparatuses for delivering tumor treating fields having electrode elements with nonuniform thicknesses and methods for manufacturing same
WO2023017490A1 (en) 2021-08-12 2023-02-16 Novocure Gmbh Transducer apparatuses with electrode array shaped to reduce edge effect in delivering tumor treating fields to a subject's body
WO2023017492A2 (en) 2021-08-12 2023-02-16 Novocure Gmbh Transducer apparatuses with electrode element spacing to reduce edge effect in delivering tumor treating fields to a subject's body
US11877838B2 (en) * 2021-08-14 2024-01-23 Nano Hesgarsazan Salamat Arya Preventing cytokine storm in COVID-19 patients by suppressing clonal expansion in activated lymphocytes using alternating electric fields
WO2023042080A1 (en) 2021-09-14 2023-03-23 Novocure Gmbh Temperature independent method and system for applying ttfields
WO2023051843A1 (en) * 2021-09-28 2023-04-06 江苏海莱新创医疗科技有限公司 Tumor electric field treatment system
WO2023051844A1 (en) * 2021-09-28 2023-04-06 江苏海莱新创医疗科技有限公司 Tumor electric field treatment system
WO2023051845A1 (en) * 2021-09-28 2023-04-06 江苏海莱新创医疗科技有限公司 Tumor electric field treatment system
US20230102915A1 (en) 2021-09-30 2023-03-30 Novocure Gmbh Method and system for applying tumor treating fields interfacing with hair follicles
WO2023084340A1 (en) 2021-11-12 2023-05-19 Novocure Gmbh Adjusting tumor treating fields simulation and treatment using molecular imaging
WO2023095111A1 (en) 2021-11-29 2023-06-01 Novocure Gmbh Methods of reducing ciliogenesis with alternating electric fields
US20230173288A1 (en) 2021-12-07 2023-06-08 Novocure Gmbh Compact dc system for delivering a square wave ac signal
WO2023105468A1 (en) 2021-12-10 2023-06-15 Novocure Gmbh Compression garment assembly for applying ttfields and methods of production and use thereof
US20230181898A1 (en) 2021-12-10 2023-06-15 Novocure Gmbh Compression garment assembly for applying ttfields and methods of production and use thereof
US20230173265A1 (en) 2021-12-10 2023-06-08 Novocure Gmbh Garment providing a biasing force on a transducer array
WO2023111855A1 (en) 2021-12-14 2023-06-22 Novocure Gmbh Shifting of transducer array to reduce skin irritation
US20230181919A1 (en) 2021-12-14 2023-06-15 Novocure Gmbh Transducer array with shape that contours to a subject's body and method of determining shape and placement of transducer arrays
US20230181918A1 (en) 2021-12-14 2023-06-15 Novocure Gmbh Transducer array with adhesive layer shaped to reduce skin irritation
US20230218912A1 (en) 2021-12-30 2023-07-13 Novocure Gmbh Selecting Values of Parameters for Treatment Using Tumor Treating Fields (TTFields)
TW202400265A (en) 2022-03-22 2024-01-01 瑞士商諾沃庫勒有限責任公司 Geometrically fitted transducers for tumor treating fields
US20230310848A1 (en) 2022-03-30 2023-10-05 Novocure Gmbh Using Interleaved Cooling Periods to Increase the Peak Intensity of Tumor Treating Fields
US20230310877A1 (en) 2022-03-30 2023-10-05 Novocure Gmbh Reducing Electrosensation Whilst Treating a Subject Using Alternating Electric Fields by Pairing Transducer Arrays Together
WO2023187751A1 (en) 2022-03-31 2023-10-05 Novocure Gmbh Alternating electric field waveform for electrosensation reduction
CN114949591A (en) * 2022-06-03 2022-08-30 江苏百宁盈创医疗科技有限公司 TTfield therapy device capable of being adjusted regionally and using method thereof
WO2023242741A1 (en) 2022-06-13 2023-12-21 Novocure Gmbh Systems and methods for increasing intestinal absorption of therapeutic agents
WO2023242825A1 (en) 2022-06-18 2023-12-21 Novocure Gmbh Compositions and methods for treating with a combination of alternating electric fields and fgf inhibitors
US20230405316A1 (en) 2022-06-20 2023-12-21 Novocure Gmbh Compositions, systems, and methods for treating cancer using tumor treating fields and vegf inhibitors
WO2023248085A1 (en) 2022-06-21 2023-12-28 Novocure Gmbh Systems and methods for treating conditions and diseases using alternating electric fields and crispr-cas system
US20240001133A1 (en) 2022-06-30 2024-01-04 Novocure Gmbh Tumor treating field transducers with protective border, and apparatuses and methods for active detection of improper transducer configuration
US20240081939A1 (en) 2022-09-08 2024-03-14 Novocure Gmbh Constructing a 3d phantom with a matrix material having conductive particles dispersed therein
WO2024062457A1 (en) 2022-09-23 2024-03-28 Novocure Gmbh Treating skin irritation from application of an alternating electric field
WO2024062456A1 (en) 2022-09-23 2024-03-28 Novocure Gmbh 3d models for predicting treatment responses to alternating electric fields
WO2024069488A1 (en) 2022-09-27 2024-04-04 Novocure Gmbh Ingestible implantable device to measure internal ttfield intensity
CA3180284A1 (en) 2022-09-29 2024-03-29 Novocure Gmbh Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment
WO2024069501A1 (en) 2022-09-29 2024-04-04 Novocure Gmbh System and method for maintaining ttfields during battery changes
WO2024069547A1 (en) 2022-09-29 2024-04-04 Novocure Gmbh Removal of background noise from image
WO2024069498A1 (en) 2022-09-29 2024-04-04 Novocure Gmbh Three-dimensional model generation for tumor treating fields transducer layout
US20240108888A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Reducing Electrosensation While Treating a Subject Using Alternating Electric Fields by Controlling Ramp-Up Characteristics
WO2024069321A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for reducing electrosensation and/or skin irritation
WO2024069531A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for treating cancer using alternating electric fields and apoptotic cancer cell vaccination
WO2024069538A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Compositions, systems, and methods for treating cancer using alternating electric fields and dendritic cells
WO2024069539A1 (en) 2022-09-30 2024-04-04 Novocure Gmbh Single wire temperature measurement solution for a ttfield application system and methods of production and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5269304A (en) * 1989-03-04 1993-12-14 Tony Matthews Electro-therapy apparatus
US20030191506A1 (en) * 2000-04-12 2003-10-09 Boris Shloznikov Method and apparatus for electromedical theraphy
US20040068297A1 (en) * 2002-10-02 2004-04-08 Yoram Palti Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR446660A (en) 1911-09-02 1912-12-12 Gottlieb Schuettel Device for continuous ring looms for mounting the sliders on the rings
BE794566A (en) 1972-01-28 1973-07-26 Esb Inc BIOELECTROCHEMICAL REGENERATOR AND STIMULATOR AND IN VIVO APPLICATION METHODS OF ELECTRIC ENERGY TO CELLS AND TISSUES.
US3991770A (en) * 1974-01-24 1976-11-16 Leveen Harry H Method for treating benign and malignant tumors utilizing radio frequency, electromagnetic radiation
US4016886A (en) 1974-11-26 1977-04-12 The United States Of America As Represented By The United States Energy Research And Development Administration Method for localizing heating in tumor tissue
US4230129A (en) * 1975-07-11 1980-10-28 Leveen Harry H Radio frequency, electromagnetic radiation device having orbital mount
US4119102A (en) * 1975-07-11 1978-10-10 Leveen Harry H Radio frequency treatment of tumors while inducing hypotension
US4121592A (en) 1975-08-04 1978-10-24 Critical Systems, Inc. Apparatus for heating tissue
US4154246A (en) * 1977-07-25 1979-05-15 Leveen Harry H Field intensification in radio frequency thermotherapy
JPS5547870A (en) 1978-02-24 1980-04-05 Lawrence Joseph L Medical treatment method
DE2813068A1 (en) * 1978-03-25 1979-10-04 Philips Patentverwaltung METHOD AND DEVICE FOR DETERMINING INTERNAL BODY STRUCTURES
JPS5520335A (en) * 1978-07-28 1980-02-13 Sawafuji Electric Co Ltd Cooler
US4263820A (en) 1978-08-23 1981-04-28 Wetherald Milo N Energy equalizing and storing device
GB2043453A (en) 1979-02-22 1980-10-08 Electrochem Tech Corp Improvements in or relating to an electrode
US4472506A (en) 1981-01-13 1984-09-18 Liburdy Robert P Method for determining cell membrane dielectric breakdown
US4467809A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for non-invasive electrical stimulation of epiphyseal plate growth
US4622952A (en) 1983-01-13 1986-11-18 Gordon Robert T Cancer treatment method
CA1244889A (en) 1983-01-24 1988-11-15 Kureha Chemical Ind Co Ltd Device for hyperthermia
DE3323415C2 (en) 1983-06-29 1985-04-25 Kernforschungsanlage Jülich GmbH, 5170 Jülich Use of a method and a device for the determination of cells secreting cell constituents
BR8607214A (en) * 1985-11-28 1988-11-01 Zahnradfabrik Friedrichshafen MECHANICAL INSTALLATION OF REMOTE CONTROL
SE455920B (en) * 1986-01-29 1988-08-22 Hans Wiksell TUMOR HYPERTERMY TREATMENT DEVICE
US4923814A (en) 1986-05-09 1990-05-08 Electropore, Inc. High speed, high power apparatus for vesicle prealignment, poration, loading and fusion in uniform electric fields and method therefor
CN86103803B (en) 1986-06-05 1987-11-18 北京信息工程学院 Therapeutic equipment using electrostatic field
JPH0511882Y2 (en) * 1987-01-06 1993-03-25
US4822470A (en) * 1987-10-09 1989-04-18 Baylor College Of Medicine Method of and apparatus for cell poration and cell fusion using radiofrequency electrical pulses
US4936303A (en) * 1987-11-20 1990-06-26 Ultrathermics Ultrasonic heating apparatus and method
JPH0629196B2 (en) 1987-12-01 1994-04-20 甲子郎 梅村 Physiological action enhancer for tumor treatment by ultrasound
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
FR2627987B3 (en) 1988-03-04 1990-02-02 Indiba Sa ELECTRONIC APPARATUS FOR MEDICAL AND COSMETIC THERAPY
US5158071A (en) * 1988-07-01 1992-10-27 Hitachi, Ltd. Ultrasonic apparatus for therapeutical use
US5099756A (en) * 1989-06-01 1992-03-31 Harry H. Leveen Radio frequency thermotherapy
DE3921808A1 (en) * 1989-07-03 1991-01-17 Schubert Werner Breaking up internal tumours using shock waves - involves gas bubbles to enhance effect in region of tumour
US5284144A (en) * 1989-11-22 1994-02-08 The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services Apparatus for hyperthermia treatment of cancer
US5441746A (en) 1989-12-22 1995-08-15 Molecular Bioquest, Inc. Electromagnetic wave absorbing, surface modified magnetic particles for use in medical applications, and their method of production
SE465754B (en) * 1990-03-05 1991-10-28 Dmitry Nikolaevich Kolmakov APPLICATOR FOR LOCAL HYPERTERMY INCLUDING A MICROWAVE RADIATION
US5224492A (en) * 1990-06-13 1993-07-06 Omron Corporation Thermotherapy apparatus
US5236410A (en) 1990-08-02 1993-08-17 Ferrotherm International, Inc. Tumor treatment method
CA2109084C (en) 1991-05-03 2004-02-24 John William Fisher Costerton Biofilm reduction method
US5441532A (en) 1991-06-26 1995-08-15 Massachusetts Institute Of Technology Adaptive focusing and nulling hyperthermia annular and monopole phased array applicators
US5683366A (en) * 1992-01-07 1997-11-04 Arthrocare Corporation System and method for electrosurgical tissue canalization
US5312513A (en) 1992-04-03 1994-05-17 Texas Instruments Incorporated Methods of forming multiple phase light modulators
US5412182A (en) * 1992-04-09 1995-05-02 City Of Hope Eddy current heating for hyperthermia cancer treatment
US5620479A (en) * 1992-11-13 1997-04-15 The Regents Of The University Of California Method and apparatus for thermal therapy of tumors
EP0597463A3 (en) * 1992-11-13 1996-11-06 Dornier Med Systems Inc Thermotherapiesonde.
US5468223A (en) 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
US5386837A (en) * 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
FR2703253B1 (en) 1993-03-30 1995-06-23 Centre Nat Rech Scient APPLICATOR OF ELECTRIC PULSES FOR TREATING BIOLOGICAL TISSUES.
US5386069A (en) * 1993-05-07 1995-01-31 Eastman Chemical Company Process for preparation of difluoro-tetraiodobenzene
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
US5704355A (en) * 1994-07-01 1998-01-06 Bridges; Jack E. Non-invasive system for breast cancer detection
US6447499B2 (en) 1995-07-28 2002-09-10 James R. Gray Use of a polarized field to modify the efficacy of a bioactive agent
US5606971A (en) 1995-11-13 1997-03-04 Artann Corporation, A Nj Corp. Method and device for shear wave elasticity imaging
US5718246A (en) 1996-01-03 1998-02-17 Preferential, Inc. Preferential induction of electrically mediated cell death from applied pulses
DE69735761T2 (en) * 1996-05-31 2006-09-14 Matsuura, Masayuki DEVICE FOR THERAPY BY REFERENCE TO LOW FREQUENCY SIGNALS RELATED TO CERTAIN DISEASES
US5984882A (en) 1996-08-19 1999-11-16 Angiosonics Inc. Methods for prevention and treatment of cancer and other proliferative diseases with ultrasonic energy
US5869326A (en) 1996-09-09 1999-02-09 Genetronics, Inc. Electroporation employing user-configured pulsing scheme
US6027499A (en) * 1997-05-23 2000-02-22 Fiber-Tech Medical, Inc. (Assignee Of Jennifer B. Cartledge) Method and apparatus for cryogenic spray ablation of gastrointestinal mucosa
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
AU9472998A (en) * 1997-09-04 1999-03-22 Science Research Laboratory, Inc. Cell separation using electric fields
US6497724B1 (en) * 1999-04-30 2002-12-24 The Board Of Trustees Of The Leland Stanford Junior University Expandable space frame
US6027488A (en) 1998-06-03 2000-02-22 Genetronics, Inc. Flow-through electroporation system for ex vivo gene therapy
US5976092A (en) 1998-06-15 1999-11-02 Chinn; Douglas O. Combination stereotactic surgical guide and ultrasonic probe
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
CA2337129A1 (en) * 1998-07-13 2000-01-20 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
EP2428250A1 (en) * 1998-07-13 2012-03-14 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6319901B1 (en) 1998-10-15 2001-11-20 Ichor Medical Systems, Inc. Methods for prolonging cell membrane permeability
US6398781B1 (en) * 1999-03-05 2002-06-04 Gyrus Medical Limited Electrosurgery system
ES2240078T3 (en) * 1999-03-09 2005-10-16 Thermage, Inc. APPARATUS FOR TREATMENT OF FABRICS.
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6738663B2 (en) 1999-04-09 2004-05-18 Oncostim, A Minnesota Corporation Implantable device and method for the electrical treatment of cancer
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
WO2000072912A1 (en) * 1999-05-26 2000-12-07 Impulse Dynamics Nv Local cardiac motion control using applied electrical signals and mechanical force
US6326177B1 (en) * 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US7110826B2 (en) 2000-01-18 2006-09-19 Shingo Motoi Cosmetic use alternating current wave forms and cosmetic device
US6853864B2 (en) 2000-02-02 2005-02-08 Catholic University Of America, The Use of electromagnetic fields in cancer and other therapies
US8447395B2 (en) 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7136699B2 (en) * 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
AU3399801A (en) 2000-02-17 2001-08-27 Yoram Palti Method and apparatus for destroying dividing cells
US7016725B2 (en) * 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
US7089054B2 (en) * 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US7465546B2 (en) * 2000-02-23 2008-12-16 The Trustees Of The University Of Pennsylvania Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields
JP3477514B2 (en) * 2000-07-04 2003-12-10 新潟大学長 Cancer hyperthermia treatment device
JP3493428B2 (en) * 2000-07-04 2004-02-03 新潟大学長 Cancer hyperthermia treatment device
US6466858B1 (en) * 2000-11-02 2002-10-15 General Electric Company Methods and apparatus for monitoring gas turbine engine operation
US6638475B1 (en) 2000-11-08 2003-10-28 The Regents Of The University Of California Method for inhibiting pathogenic and spoilage activity in products
CZ298160B6 (en) * 2001-01-18 2007-07-11 Apparatus for inducing an immune response in cancer therapy
US20020198567A1 (en) * 2001-06-07 2002-12-26 Yona Keisari Electro-endocytotic therapy as a treatment modality of cancer
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US7130694B1 (en) * 2001-12-26 2006-10-31 Advanced Bionics Corporation Pulse skipping strategy
US7162303B2 (en) * 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20040152997A1 (en) * 2002-05-20 2004-08-05 Davies Richard J. Electrophysiological approaches to assess resection and tumor ablation margins and responses to drug therapy
JP4152695B2 (en) 2002-08-28 2008-09-17 株式会社アビー Method for producing fresh frozen raw vegetables
US6858899B2 (en) * 2002-10-15 2005-02-22 Matrix Semiconductor, Inc. Thin film transistor with metal oxide layer and method of making same
US6964726B2 (en) * 2002-12-26 2005-11-15 Kimberly-Clark Worldwide, Inc. Absorbent webs including highly textured surface
US7720549B2 (en) * 2004-04-06 2010-05-18 Oncostim, Inc. Partially implantable system for the electrical treatment of abnormal tissue growth
WO2005115535A2 (en) * 2004-04-23 2005-12-08 Novocure Ltd. Treating a tumor or the like with electric fields at different frequencies
DE102004028156A1 (en) 2004-06-09 2006-01-05 Kalbe, Jochen, Dr. Combination of radio waves and one or more of monoclonal antibodies, tyrosine-kinase inhibitors, angiogenesisi inhibitors, farnesyl transferase inhibitors, topoisomerase - I or II inhibitors, cytokine and antisense oligonucleotides
US20060047328A1 (en) * 2004-08-31 2006-03-02 Patrick Murphy Multi-frequency electrical field generator and use thereof
DK2345451T3 (en) 2004-12-07 2018-04-23 Novocure Ltd Electrodes for applying an electric field in vivo over an extended period of time
JP5559460B2 (en) 2004-12-27 2014-07-23 スタンデン・リミテッド Method for treating tumors or the like using electric fields of different orientations
US8788044B2 (en) 2005-01-21 2014-07-22 Michael Sasha John Systems and methods for tissue stimulation in medical treatment
US7548780B2 (en) * 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
AU2006239957A1 (en) * 2005-04-21 2006-11-02 Epi-Sci, Llc Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue and epithelium
PT1899001T (en) 2005-06-08 2017-12-01 Novocure Ltd Apparatus for treating cancer with electric fields that are guided to desired locations within a body
JP2009520509A (en) 2005-10-03 2009-05-28 ノヴォキュアー・リミテッド Electric field optimization properties to increase the effect of electric fields in proliferating cells
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
US20070255320A1 (en) * 2006-04-28 2007-11-01 Cyberonics, Inc. Method and apparatus for forming insulated implantable electrodes
DE102006050369A1 (en) 2006-10-25 2008-04-30 Oncotherm Kft. Hyperthermia device for the selective treatment and monitoring of surface tissue
DK2167194T3 (en) 2007-03-06 2017-06-19 Novocure Ltd TREATMENT OF CANCER USING ELECTROMAGNETIC FIELDS IN COMBINATION WITH PHOTODYNAMIC THERAPY
WO2009022225A1 (en) 2007-08-14 2009-02-19 Novocure Ltd. Treating parasites with electric fields
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5269304A (en) * 1989-03-04 1993-12-14 Tony Matthews Electro-therapy apparatus
US20030191506A1 (en) * 2000-04-12 2003-10-09 Boris Shloznikov Method and apparatus for electromedical theraphy
US20040068297A1 (en) * 2002-10-02 2004-04-08 Yoram Palti Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11850422B2 (en) 2019-04-23 2023-12-26 Boston Scientific Scimed, Inc. Electrodes for electrical stimulation to treat cancer

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US20050240228A1 (en) 2005-10-27
US20120283726A1 (en) 2012-11-08
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