WO2006020299A2 - Method and system to control skeletal muscles by means of neuro-electrical coded signals - Google Patents
Method and system to control skeletal muscles by means of neuro-electrical coded signals Download PDFInfo
- Publication number
- WO2006020299A2 WO2006020299A2 PCT/US2005/025622 US2005025622W WO2006020299A2 WO 2006020299 A2 WO2006020299 A2 WO 2006020299A2 US 2005025622 W US2005025622 W US 2005025622W WO 2006020299 A2 WO2006020299 A2 WO 2006020299A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- waveform
- skeletal muscle
- signal
- control
- waveform signal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36042—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of grafted tissue, e.g. skeletal muscle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
Definitions
- the present invention relates generally to medical methods and systems for monitoring and controlling skeletal muscles. More particularly, the invention relates to a method and system for controlling skeletal muscles by means of transmitted neuro- electrical coded signals.
- the brain modulates (or controls) skeletal muscles via electrical signals (i.e., action potentials or waveform signals), which are transmitted through the nervous system.
- the nervous system includes the central nervous system, which comprises the brain and the spinal cord, and the cranial and peripheral nervous systems, which generally comprise groups of nerve cells (i.e., neurons) and peripheral nerves that lie outside the brain and spinal cord.
- the various nerve networks and systems are anatomically separate, but functionally interconnected.
- the peripheral nervous system is constructed of nerve cells (or neurons) and glial cells (or glia), which support the neurons.
- Operative neuron units that carry signals from the brain are referred to as “efferent” nerves.
- "Afferent” nerves are those that carry sensor or status information to the brain. Together, these components of the nervous system are responsible for the function, regulation and modulation of the body's organs, muscles, secretory glands and other physiological systems.
- a typical neuron includes four morphologically defined regions: (i) cell body, (ii) dendrites, (iii) axon and (iv) presynaptic terminals.
- the cell body (soma) is the metabolic center of the cell.
- the cell body contains the nucleus, which stores the genes of the cell, and the rough and smooth endoplasmic reticulum, which synthesizes the proteins of the cell.
- the nerve cell body typically includes two types of outgrowths (or processes); the dendrites and the axon. Most neurons have several dendrites; these branch out in tree-like fashion and serve as the main apparatus for receiving signals from other nerve cells.
- the axon is the main conducting unit of the neuron.
- the axon carries coded electrical signals to the body's organs, skeletal muscles and other physiological systems to control the function thereof.
- the axon is capable of conveying electrical signals along distances that range from as short as 0.1 mm to as long as 2 m.
- the axon is divided into fine branches that make contact with other neurons.
- the point of contact is referred to as a synapse.
- the cell transmitting a signal is called the presynaptic cell.
- the cell receiving the signal is referred to as the postsynaptic cell.
- Specialized swellings on the axon's branches i.e., presynaptic terminals serve as the transmitting site in the presynaptic cell.
- the electrical signals transmitted along the axon are rapid and transient "all-or-none" nerve impulses.
- Action potentials typically have an amplitude of less than approximately 100 millivolts (mV) and a duration of approximately 1 msec.
- Action potentials are conducted along the axon, without failure or distortion, at rates in the range of approximately 1 - 100 meters/sec.
- the amplitude of the action potential remains constant throughout the axon, since the impulse is continually regenerated as it traverses the axon.
- a "neurosignal" is a composite signal that includes many action potentials.
- the neurosignal also includes an instruction set for proper organ function and/or system.
- a skeletal muscle neurosignal would thus include an instruction set for a muscle to perform a desired movement, including information regarding initial muscle tension, degree of muscle movement, etc.
- Neurosignals or "neuro-electrical coded signals” are thus codes that contain complete sets of information for complete organ function.
- a generated nerve-specific waveform instruction i.e., waveform signal(s)
- the noted impairments include, but are not limited to, spinal injuries, brain tumor, multiple sclerosis, cerebral palsy, radiation-induced nerve damage, stroke induced neuron damage, etc.
- U.S. Pat. No. 6,651,652 a system and method for treating sleep apnea is disclosed.
- the noted system includes a respiration sensor that is adapted to capture neuro-electrical signals and extract the signal components related to respiration. The signals are similarly processed and employed to control a ventilator.
- U.S. Patent No. 5,167,229 a method and system for inducing skeletal muscle movement is disclosed.
- the method includes the step of implanting a sensor, i.e., input command means, in the body that is adapted to sense physical movement and provide a signal "which is indicative of a selected physiological movement or group of movements.”
- the signal is then processed and employed to control implanted electrodes that are adapted to stimulate target muscles.
- control signals that are generated and transmitted are "user determined” and “device determinative”.
- the noted “control signals” are thus not related to or representative of the signals that are generated in the body and, hence, would not be operative in the control of the skeletal muscles if transmitted thereto.
- the method to control skeletal muscles in one embodiment of the invention generally comprises (i) generating at least a first coded waveform signal that substantially corresponds to at least one coded waveform signal that is generated in the body and is recognizable by at least a first skeletal muscle as a control signal and (ii) transmitting the first waveform signal to a subject to control the first skeletal muscle.
- the method to control skeletal muscles generally comprises (i) capturing coded waveform signals that are generated in the body and are operative in the control of at least a first skeletal muscle, (ii) generating at least a first waveform signal that is recognizable by the first skeletal muscle as a control signal, and (iii) transmitting the first waveform signal to a subject to control the first skeletal muscle.
- the first waveform signal includes at least a second waveform signal that substantially corresponds to at least one of the captured waveform signals and is operative in the control of the first skeletal muscle.
- the first waveform signal is transmitted to the subject's nervous system. In another embodiment, the first waveform signal is transmitted proximate to a target zone on the neck, head or spinal region.
- the method to control skeletal muscles generally comprises (i) capturing coded waveform signals that are generated in the body and are operative in the control of skeletal muscles, (ii) storing the captured waveform signals in a storage medium, the storage medium being adapted to store the components of the captured waveform signals according to the function performed by the waveform signal components, (iii) generating at least a first waveform signal that substantially corresponds to at least one of the captured waveform signals and is operative in the control of at least a first skeletal muscle, and (iv) transmitting the first waveform signal to a subject to control the first skeletal muscle.
- the method to control skeletal muscles generally comprises (i) capturing a plurality of waveform signals generated in a first subject's body that are operative in the control of skeletal muscles, (ii) generating a base ⁇ line skeletal muscle waveform signal from the plurality of captured waveform signals, the base-line skeletal muscle waveform being operative in the control of a first skeletal muscle (iii) capturing a second waveform signal generated in the first subject's body that is operative in the control of the first skeletal muscle, (iv) comparing the base-line waveform signal to the second waveform signal, (v) generating a third waveform signal based on the comparison of the base-line and second waveform signals, and (vi) transmitting the third waveform signal to the first subject's body, the third waveform signal being operative in the control of the first skeletal muscle.
- the plurality of waveform signals is captured from a second subject's body.
- the plurality of waveform signals is captured from a plurality of subjects.
- the third waveform signal is transmitted to the subject's nervous system.
- the third waveform signal is transmitted proximate to a target zone on the neck, head or spinal region.
- the method for controlling skeletal muscles generally comprises (i) monitoring the status of at least a first skeletal muscle of a subject, (ii) providing at least one skeletal muscle status signal in response to a skeletal muscle disorder of the first skeletal muscle, (iii) generating at least a first waveform signal that is operative in the control of the first skeletal muscle in response to the skeletal muscle status signal, and (iv) transmitting the first waveform signal to the subject to mitigate the skeletal muscle disorder.
- the method for controlling skeletal muscles generally comprises (i) capturing waveform signals that are generated in the body and are operative in control of skeletal muscles, the waveform signals including at least a first waveform signal that is operative in the control of a first skeletal muscle, (ii) monitoring the skeletal muscle status of the first skeletal muscle of a subject and providing at least one skeletal muscle status signal indicative of the status of the first skeletal muscle, (iii) storing the captured waveform signals and skeletal muscle status signal in a storage medium, (iv) generating at least a first waveform that is operative in the control of the first skeletal muscle in response to a skeletal muscle status signal or component of a captured waveform signal that is indicative of a skeletal muscle disorder, and (v) transmitting the first waveform signal to the subject to mitigate the skeletal muscle disorder.
- the method to control skeletal muscles generally comprises (i) capturing a first plurality of waveform signals generated in the body that are operative in the control of skeletal muscles, (ii) capturing at least a first waveform signal from a subject's body that is indicative of a skeletal muscle disorder, (iii) generating a confounding signal that is operative to mitigate the skeletal muscle disorder, and (iv) transmitting the confounding waveform signal to the subject to mitigate the skeletal muscle disorder.
- the system to control skeletal muscles in accordance with one embodiment of the invention, generally comprises (i) at least a first signal probe adapted to capture coded waveform signals from the body, the waveform signals being representative of waveform signals naturally generated in the body and operative in the control of skeletal muscles, (ii) a processor in communication with the signal probe and adapted to receive the waveform signals, the processor being further adapted to generate at least a first waveform signal based on the captured waveform signals, the first waveform signal being recognizable by at least a first skeletal muscle as a control signal and (iii) at least a second signal probe adapted to be in communication with a subject's body for transmitting the first waveform signal to the body to control the first skeletal muscle.
- the processor includes a storage medium adapted to store the captured waveform signals.
- the processor is adapted to extract and store components of the captured waveform signals in the storage means according to the function performed by the signal components.
- FIGURES I A through I D are illustrations of waveform signals captured from the body that are operative in the control of the skeletal muscles of the arm forearm, hands and fingers;
- FIGURE 2 is an illustration of the skeletal muscles of the upper body (posterior view);
- FIGURE 3 is an illustration of the skeletal muscles of the right shoulder and chest regions (anterior view);
- FIGURE 4 is an illustration of the skeletal muscles of the right arm (anterior view);
- FIGURE 5 is a further illustration of the skeletal muscles of the right arm, showing the deep layer muscle structure (anterior view);
- FIGURE 6 is an illustration of the skeletal muscles of the right arm (posterior view);
- FIGURE 7 is a further illustration of the skeletal muscles of the right arm, showing the deep layer muscle structure (posterior view);
- FIGURES 8A and 8B are illustrations of the skeletal muscles of the right forearm (posterior views);
- FIGURE 9 is an illustration of the skeletal muscles of the right hand (anterior view).
- FIGURE 10 is a schematic illustration of one embodiment of a skeletal muscle control system, according to the invention.
- FIGURE 1 1 is a schematic illustration of another embodiment of a skeletal muscle control system, according to the invention.
- FIGURE 12 is a schematic illustration of another embodiment of a skeletal muscle control system, according to the invention.
- FIGURE 13 is a schematic illustration of yet another embodiment of a skeletal muscle control system, according to the invention.
- neural system means and includes the central nervous system, including the spinal cord, medulla, pons, cerebellum, midbrain, diencephalon and cerebral hemispheres, and the cranial and peripheral nervous systems, including the neurons and glia.
- coded waveform signal and “waveform signal”, as used herein, mean and include a composite electrical signal that is generated in the body and carried by neurons in the body, including neurocodes, neurosignals and components and segments thereof.
- skeletal muscle means and includes a striated muscle, normally having at least one attachment to the skeletal system, whose contraction and extension are controlled or mediated by cognitive action.
- target zone means and includes, without limitation, a region of the body proximal to a portion of the nervous system whereon the application of electrical signals can induce the desired neural control without the direct application (or conduction) of the signals to a target nerve.
- patient and “subject”, as used herein, mean and include humans and animals.
- plexus means and includes a branching or tangle of nerve fibers outside the central nervous system.
- ganglion means and includes a group or groups of nerve cell bodies located outside the central nervous system.
- skeletal muscle impairment and “skeletal muscle disorder”, as used herein, mean and include any dysfunction of a skeletal muscle that impedes the normal function thereof. Such dysfunction can be caused by a multitude of known factors and events, including, without limitation, spinal cord injury and severance, a brain tumor, multiple sclerosis, cerebral palsy and involuntary muscle contractions.
- the system for controlling skeletal muscles generally comprises means for generating at least one waveform signal that substantially corresponds to at least one waveform signal (i.e., coded electrical neurosignal) that is generated in the body and is operative in the control of at least a first skeletal muscle and means for transmitting the waveform signal to a subject's body.
- the waveform signal is transmitted to the subject's nervous system.
- the system includes means for recording waveform signals from a subject's body that are operative in the control of at least the first skeletal muscle.
- the "subject" can be the same subject that the generated waveform signals are transmitted to or a different subject.
- Figs. 2 through 9 there are shown illustrations of various skeletal muscles and muscle structures of the upper body, which can be controlled through the use of the methods and system of the invention.
- the skeletal muscles of the shoulder and upper arm include the levator scapulae, major and minor rhomboids, deltoids, supraspinatus, trapezius, pectoralis, coracobrachialis, biceps and triceps brachii, and latissimus dorsi.
- the skeletal muscles of the forearm, wrist and hand include the extensor and flexor digitorums, extensor carpi ulnaris, abductor and flexor pollicis longus, lumbrical, opponens and adductor pollicis muscles, and finger and wrist flexors.
- skeletal muscles of the upper body are illustrated, the skeletal muscles of the lower body are similarly within the scope of the present invention.
- Such skeletal muscles include, without limitation, the quadriceps, hamstrings, adductor longus, vastus lateralis, intermedius and medialis muscles, and the sartorius.
- coded waveform signals related to skeletal muscle operation and control originate in various brain structures.
- the waveform signals are primarily transmitted through the spinal cord.
- the waveform signals that control the noted skeletal muscles of the shoulder, arm, wrist and hand are also transmitted through the brachial plexus, and the radial, median and ulnar nerves.
- the waveform signals that control a target skeletal muscle or muscles can be captured or collected along any of the nerves carrying the waveform signals to the target skeletal muscle.
- the waveform signals transmitted to the abductor pollicis muscle of the hand can be captured from the brachial plexus.
- Methods and systems for capturing coded signals from specific nerves in the body, and for storing, processing and transmitting neuro-electrical signals (or coded waveform signals) are set forth in Co-Pending Application Nos. 10/000,005, filed November 20, 2001 , and Application No. 1 1/125,480, filed May 9, 2005; which are incorporated by reference herein in their entirety.
- Figs. I A through 1 D there are shown exemplar waveform signals that are operative in the control of the skeletal muscles of the arm, forearm, hands and fingers.
- the signals 16, 17 shown in Figs. IA and IB bring the arm upward and pull the hand back with the fingers spread.
- the signals 28, 30 shown Figs. 1C and ID provide the same movement as the signals shown in Figs. IA and IB with less intensity (i.e., moderate movement).
- each signal 16, 17 includes a negative segment 18, which is believed to reflect the muscle and/or nerve setting up for movement. Following the negative segment 18 is a large positive segment 20, which produces the desired movement, and a negative segment 22, thereafter reflecting the rest and evaluation segment of the signal.
- the noted signals include coded information related to muscle movement function, such as initial muscle tension, degree (or depth) of muscle movement, etc.
- coded waveform signals generated in the body that are operative in the control of skeletal muscles are captured and transmitted to a processor or control module.
- the control module includes storage means adapted to store the captured signals.
- the control module is further adapted to store the components of the captured signals (that are extracted by the processor) in the storage means according to the function performed by the signal components.
- the stored signals can subsequently be employed to establish at least one, preferably, multiple base-line skeletal muscle waveform signals.
- the module can then be programmed to compare skeletal muscle waveform signals (and components thereof) captured from a subject and, as discussed below, generate at least one waveform signal or modified base-line waveform signal for transmission to the same or a different subject.
- Such modification can include, for example, increasing the amplitude of a skeletal muscle signal to provide a quicker or more powerful muscle movement.
- the captured waveform signals are preferably processed by proprietary means and a waveform signal (i.e., coded electrical neurosignal) that is representative of at least one captured waveform signal and operative in the control of at least one skeletal muscle (i.e., recognized by the brain or at least one skeletal muscle as a control signal) is generated by the control module.
- a waveform signal i.e., coded electrical neurosignal
- the noted waveform signal is preferably similarly stored in the storage means of the control module.
- the generated waveform signal is accessed from the storage means and transmitted to the subject via a transmitter (or treatment member) to control a target skeletal muscle or muscles.
- a transmitter or treatment member
- various transmitters can be employed within the scope of the invention to transmit the generated waveform signals to a subject.
- the applied voltage of a transmitted waveform signal can be up to 20 volts AC (up to 3 volts DC) to allow for voltage loss during the transmission of the signals.
- current is maintained to less than 2 amp output.
- Direct conduction into the nerves via electrodes connected directly to such nerves preferably have outputs less than 3 volts AC and current less than one tenth of an amp.
- the control system 2OA includes a control module 22, which is adapted to receive coded neurosignals or "waveform signals" from a skeletal muscle signal sensor (shown in phantom and designated 21) that is in communication with a subject, and at least one treatment member 24.
- a control module 22 which is adapted to receive coded neurosignals or "waveform signals" from a skeletal muscle signal sensor (shown in phantom and designated 21) that is in communication with a subject, and at least one treatment member 24.
- the treatment member 24 is adapted to communicate with the body and receives generated waveform signals from the control module 22.
- the treatment member 24 can comprise an electrode, antenna, a seismic transducer, or any other suitable form of conduction attachment for transmitting skeletal muscle waveform signals that control skeletal muscle function in human and animals.
- the treatment member 24 can be attached to appropriate nerves via a surgical process. Such surgery can, for example, be accomplished with "key-hole" entrance in a thoracic-stereo-scope procedure. If necessary, a more expansive thoracotomy or other surgical approach can be employed for placement of the treatment member 24.
- control module 22 and treatment member 24 can be entirely separate elements, which allow system 2OA to be operated remotely.
- the control module 22 can be unique, i.e., tailored to a specific operation and/or subject, or can comprise a conventional device.
- Fig 1 1 there is shown a further embodiment of a control system 2OB of the invention. As illustrated in Fig. 1 1, the system 2OB is similar to system 2OA shown in Fig. 10. However, in this embodiment, the control module 22 and treatment member 24 are connected.
- control system 2OC similarly includes a control module 22 and a treatment member 24.
- the system 2OC further includes at least one skeletal muscle signal sensor 21.
- the system 2OC also includes a processing module (or computer) 26.
- the processing module 26 can be a separate component or can be a sub-system of a control module 22', as shown in phantom.
- the processing module (or control module) 26 preferably includes storage means adapted to store the captured skeletal muscle waveform signals.
- the processing module 26 is further adapted to extract and store the components of the captured skeletal muscle waveform signals in the storage means according to the function performed by the signal components.
- the method for controlling skeletal muscles includes the following steps: (i) generating at least a first coded waveform signal that substantially corresponds to at least one coded waveform signal that is generated in the body and is recognizable by at least a first skeletal muscle as a control signal and (ii) transmitting the first waveform signal to a subject to control the first skeletal muscle.
- the first waveform signal is transmitted to the subject's nervous system. In another embodiment, the first waveform signal is transmitted proximate to a target zone on the neck, head or spinal region.
- the generated waveform signal is preferably transmitted to the subject via a constant current or constant voltage method.
- the constant current method allows for the voltage level to fluctuate as the resistance changes.
- a positive and negative probe (the negative probe located cranial to the positive probe) are attached to a target nerve.
- the distance between the probes is preferably approximately 2 cm.
- a ground connection is also made between the interior muscles and an earth ground.
- a signal probe is attached to the target nerve. While the signal probe is capable of providing both the positive and negative portions of the neuro-code, only the positive portion of the neuro-code is used to stimulate the nerve. The signal ground probe is not required. A ground connection is similarly made between the interior muscles and an earth ground.
- the method to control skeletal muscles generally comprises (i) capturing waveform signals that are generated in the body and are operative in the control of at least a first skeletal muscle, (ii) generating at least a first waveform signal that is recognizable by the first skeletal muscle as a control signal, and (iii) transmitting the first waveform signal to a subject to control the first skeletal muscle.
- the first waveform signal includes at least a second waveform signal that substantially corresponds to at least one of the captured waveform signals and is operative in the control of the first skeletal muscle.
- the first waveform signal is transmitted to the subject's nervous system. In another embodiment, the first waveform signal is transmitted proximate to a target zone on the neck, head or spinal region.
- the method to control skeletal muscles generally comprises (i) capturing waveform signals that are generated in the body and are operative in control of skeletal muscles, (ii) storing the captured waveform signals in a storage medium, the storage medium being adapted to store the components of the captured waveform signals according to the function performed by the signal components, (iii) generating at least a first waveform signal that substantially corresponds to at least one of the captured waveform signals and is operative in the control of at least a first skeletal muscle, and (iv) transmitting the first waveform signal to a subject.
- the method to control skeletal muscles generally comprises (i) capturing a first plurality of waveform signals generated in a first subject's body that are operative in the control of skeletal muscles, (ii) generating a base-line skeletal muscle waveform signal from the first plurality of waveform signals, the base-line skeletal muscle waveform being operative in the control of a first skeletal muscle (iii) capturing a second waveform signal generated in the first subject's body that is operative in the control of the first skeletal muscle, (iv) comparing the base-line waveform signal to the second waveform signal, (v) generating a third waveform signal based on the comparison of the base-line and second waveform signals, and (vi) transmitting the third waveform signal to the first subject, the third waveform signal being operative in the control of the first skeletal muscle.
- the first plurality of waveform signals is captured from a second subject's body.
- the first plurality of waveform signals is captured from a plurality of subjects.
- the first and third waveform signals are transmitted to the subject's nervous system.
- the first waveform signal is transmitted proximate to a target zone on the neck, head or spinal region.
- the step of transmitting the waveform signals of the invention to a subject can be accomplished by direct conduction via attachment of an electrode to the receiving nerve or nerve plexus. As discussed, this requires a surgical intervention to physically attach the electrode to the selected target nerve.
- the step of transmitting the waveform signals of the invention to a subject can also be accomplished by transposing the waveform signal into a seismic form.
- the seismic signal is then sent into a region of the head, neck, or spinal region in a manner that allows the appropriate "nerve” to receive and obey the coded instructions of the seismic signal.
- the present invention thus provides methods and apparatus to effectively control skeletal muscles.
- the methods and apparatus can thus be employed to restore some or most appendage (i.e., arm, hand and leg) movement in paralyzed subjects.
- the methods and apparatus of the invention can also be employed in the treatment of various skeletal muscle impairments or disorders, such as involuntary muscle contractions resulting from hypertonia and spasticity.
- a skeletal muscle control system 30 that can be employed in the treatment of various skeletal muscle impairments and disorders.
- the system 30 includes at least one skeletal muscle sensor 32 that is adapted to monitor the skeletal muscle function or status of at least a first skeletal muscle of a subject and transmit at least one signal indicative of the first skeletal muscle status.
- the first skeletal muscle status can be determined by a multitude of factors, including skeletal muscle movement or lack thereof, muscle tension, etc.
- Various sensors can thus be employed within the scope of the invention to detect the noted factors and, hence, a skeletal muscle impairment or disorder.
- the system 30 further includes a processor 36, which is adapted to receive the skeletal muscle status signal(s) from the skeletal muscle sensor 32.
- the processor 36 is further adapted to receive skeletal muscle waveform signals recorded by a skeletal muscle signal probe (shown in phantom and designated 34).
- the processor 36 includes storage means for storing the captured, waveform signals and skeletal muscle status signals.
- the processor 36 is further adapted to extract the components of the waveform signals and store the signal components in the storage means.
- the processor 36 is programmed to detect skeletal muscle status signals indicative of skeletal muscle impairments and/or disorders and/or waveform signals and components thereof indicative of skeletal muscle disorders and generate at least one waveform signal that is operative in the control of at least one skeletal muscle.
- the processor 36 is programmed to detect a skeletal muscle status signal indicative of a first skeletal muscle disorder and generate at least a first waveform signal that is operative in the control of the first skeletal muscle, which, when transmitted to the subject (as discussed below) mitigates the first skeletal muscle disorder.
- the generated waveform signal is routed to a transmitter 38 that is adapted to be in communication with the subject's body.
- the transmitter 38 is further adapted to transmit the waveform signal to the subject's body (in a similar manner as described above) to control the affected skeletal muscle and, preferably, mitigate the detected skeletal muscle disorder.
- the waveform signal is preferably transmitted to one or more nerves that are in communication with the affected skeletal muscle.
- a single waveform signal or a plurality of signals can be transmitted in conjunction with one another.
- the method for controlling skeletal muscles generally comprises (i) monitoring the status of at least a first skeletal muscle of a subject, (ii) providing at least one skeletal muscle status signal in response to a skeletal muscle disorder of the first skeletal muscle, (iii) generating at least a first waveform signal that is operative in the control of the first skeletal muscle in response to the skeletal muscle status signal, and (iv) transmitting the first waveform signal to the subject to mitigate the skeletal muscle disorder.
- the method for controlling skeletal muscles generally comprises (i) capturing waveform signals that are generated in the body and are operative in control of skeletal muscles, the waveform signals including at least a first waveform signal that is operative in the control of a first
- skeletal muscle (ii) monitoring the skeletal muscle status of the first skeletal muscle of a subject and providing at least one skeletal muscle status signal indicative of the status of the first skeletal muscle, (iii) storing the captured waveform signals and skeletal muscle status signal in a storage medium, (iv) generating at least a first waveform that is operative in the control of the first skeletal muscle in response to a skeletal muscle status signal or component of a captured waveform signal that is indicative of a skeletal muscle disorder, and (v) transmitting the first waveform signal to the subject to mitigate the skeletal muscle disorder.
- the method to control skeletal muscles generally comprises (i) capturing a first plurality of waveform signals generated in the body that are operative in the control of skeletal muscles, (ii) capturing at least a first waveform signal from a subject's body that is indicative of a skeletal muscle disorder, (iii) generating a confounding signal that is operative to mitigate the skeletal muscle disorder, and (iv) transmitting the confounding waveform signal to the subject to mitigate the skeletal muscle disorder.
- the present invention provides numerous advantages. Among the advantages are the provision of a system, apparatus and method to control skeletal muscles that can be readily and effectively employed in the treatment of various skeletal muscle impairments and disorders, including involuntary muscle movement (e.g., spasms and muscle contractions) and partial or full loss of muscle movement or control resulting from spinal injuries, multiple sclerosis, cerebral palsy, radiation-induced nerve damage, stroke induced neuron damage, etc.
- involuntary muscle movement e.g., spasms and muscle contractions
- partial or full loss of muscle movement or control resulting from spinal injuries multiple sclerosis, cerebral palsy, radiation-induced nerve damage, stroke induced neuron damage, etc.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05773503A EP1786512A2 (en) | 2004-07-30 | 2005-07-20 | Method and system to control skeletal muscles by means of neuro-electrical coded signals |
CA002575558A CA2575558A1 (en) | 2004-07-30 | 2005-07-20 | Method and system to control skeletal muscles by means of neuro-electrical coded signals |
AU2005274723A AU2005274723A1 (en) | 2004-07-30 | 2005-07-20 | Method and system to control skeletal muscles by means of neuro-electrical coded signals |
JP2007523642A JP2008508031A (en) | 2004-07-30 | 2005-07-20 | Method and apparatus for controlling skeletal muscle with a neuroelectrically encoded signal |
MX2007001056A MX2007001056A (en) | 2004-07-30 | 2005-07-20 | Method and system to control skeletal muscles by means of neuro-electrical coded signals. |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59275104P | 2004-07-30 | 2004-07-30 | |
US60/592,751 | 2004-07-30 | ||
US60243804P | 2004-08-18 | 2004-08-18 | |
US60/602,438 | 2004-08-18 | ||
US60427904P | 2004-08-24 | 2004-08-24 | |
US60/604,279 | 2004-08-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006020299A2 true WO2006020299A2 (en) | 2006-02-23 |
WO2006020299A3 WO2006020299A3 (en) | 2007-02-15 |
Family
ID=35908002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/025622 WO2006020299A2 (en) | 2004-07-30 | 2005-07-20 | Method and system to control skeletal muscles by means of neuro-electrical coded signals |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1786512A2 (en) |
JP (1) | JP2008508031A (en) |
AU (1) | AU2005274723A1 (en) |
CA (1) | CA2575558A1 (en) |
MX (1) | MX2007001056A (en) |
WO (1) | WO2006020299A2 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6633779B1 (en) * | 2000-11-27 | 2003-10-14 | Science Medicus, Inc. | Treatment of asthma and respiratory disease by means of electrical neuro-receptive waveforms |
-
2005
- 2005-07-20 JP JP2007523642A patent/JP2008508031A/en active Pending
- 2005-07-20 EP EP05773503A patent/EP1786512A2/en not_active Withdrawn
- 2005-07-20 CA CA002575558A patent/CA2575558A1/en not_active Abandoned
- 2005-07-20 AU AU2005274723A patent/AU2005274723A1/en not_active Abandoned
- 2005-07-20 MX MX2007001056A patent/MX2007001056A/en not_active Application Discontinuation
- 2005-07-20 WO PCT/US2005/025622 patent/WO2006020299A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6633779B1 (en) * | 2000-11-27 | 2003-10-14 | Science Medicus, Inc. | Treatment of asthma and respiratory disease by means of electrical neuro-receptive waveforms |
Also Published As
Publication number | Publication date |
---|---|
WO2006020299A3 (en) | 2007-02-15 |
AU2005274723A1 (en) | 2006-02-23 |
EP1786512A2 (en) | 2007-05-23 |
JP2008508031A (en) | 2008-03-21 |
MX2007001056A (en) | 2007-04-12 |
CA2575558A1 (en) | 2006-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20050288732A1 (en) | Method and system to control skeletal muscles by means of neuro-electrical coded signals | |
Micera et al. | Decoding information from neural signals recorded using intraneural electrodes: toward the development of a neurocontrolled hand prosthesis | |
Graupe | EMG pattern analysis for patient-responsive control of FES in paraplegics for walker-supported walking | |
Lynch et al. | Functional electrical stimulation | |
Del Valle et al. | Interfaces with the peripheral nerve for the control of neuroprostheses | |
US20050251061A1 (en) | Method and system to record, store and transmit waveform signals to regulate body organ function | |
CN108744270A (en) | Neural stimulation system for nervous centralis stimulation and peripheral nerve stimulation | |
WO2021036165A1 (en) | Closed-loop electrical spinal cord stimulation system | |
Hamilton et al. | Electrical nerve stimulation modulates motor unit activity in contralateral biceps brachii during steady isometric contractions | |
Weber et al. | Sensory information feedback for neural prostheses | |
CN108778404B (en) | System for regenerating at least one severed nerve conduction | |
JPH0328225B2 (en) | ||
US20140350637A1 (en) | Bioelectronics for controlling skeletal muscles by neuro-electrical coded signals | |
US20110098783A1 (en) | Method and system to regulate arms, legs, hands and other skeletal muscles by neuro-electrical coded signals | |
WO2006020299A2 (en) | Method and system to control skeletal muscles by means of neuro-electrical coded signals | |
Takahashi et al. | Fundamental research about electroencephalogram (EEG)-functional electrical stimulation (FES) rehabilitation system | |
KR102050261B1 (en) | Functional electrical stimulation system and controlling method thereof | |
Lou et al. | Research on Microelectronic System of Antagonism Inhibiting Spasticity Based on Electro-Myo-Graphic Bridge | |
Liu | The Application of Brain-computer Interface (BCI) based Functional Electrical Stimulation (FES) | |
US20040260360A1 (en) | Skeletal muscle control by means of neuro-electrical signals | |
Hwang et al. | Closed-loop control of functional electrical stimulation using a selectively recording and bidirectional nerve cuff interface | |
Chopra et al. | Brain computer interface and electro stimulation of muscles to assist paralyzed patients in limited movement of hands | |
CN112245797A (en) | Movable backpack type stroke hemiplegia upper limb function rehabilitation training system | |
Mangrulkar | Design of Neuromuscular Stimulation to Supervise Parallelized Arm Using Human-Machine-Human Interaction | |
Mohammed | SMART ELECTRICAL MUSCLE STIMULATOR USING RASPBERRY PI4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2005274723 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2005274723 Country of ref document: AU Date of ref document: 20050720 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/a/2007/001056 Country of ref document: MX |
|
WWP | Wipo information: published in national office |
Ref document number: 2005274723 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007523642 Country of ref document: JP Ref document number: 2575558 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005773503 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2005773503 Country of ref document: EP |