WO2006026766A3 - Frequency-multiplexed detection of multiple wavelength light for flow cytometry - Google Patents

Frequency-multiplexed detection of multiple wavelength light for flow cytometry Download PDF

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Publication number
WO2006026766A3
WO2006026766A3 PCT/US2005/031493 US2005031493W WO2006026766A3 WO 2006026766 A3 WO2006026766 A3 WO 2006026766A3 US 2005031493 W US2005031493 W US 2005031493W WO 2006026766 A3 WO2006026766 A3 WO 2006026766A3
Authority
WO
WIPO (PCT)
Prior art keywords
frequency
flow cytometry
wavelength light
multiple wavelength
multiplexed detection
Prior art date
Application number
PCT/US2005/031493
Other languages
French (fr)
Other versions
WO2006026766A2 (en
Inventor
James A Cox
David J Zook
Original Assignee
Honeywell Int Inc
James A Cox
David J Zook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Honeywell Int Inc, James A Cox, David J Zook filed Critical Honeywell Int Inc
Priority to EP05794052.0A priority Critical patent/EP1784630B1/en
Priority to CN2005800366981A priority patent/CN101052867B/en
Priority to JP2007530436A priority patent/JP2008511843A/en
Publication of WO2006026766A2 publication Critical patent/WO2006026766A2/en
Publication of WO2006026766A3 publication Critical patent/WO2006026766A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1438—Using two lasers in succession
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/069—Supply of sources
    • G01N2201/0691—Modulated (not pulsed supply)

Abstract

A multiplexed set of light sources having outputs of light with various wavelengths which are combined into one beam. The beam may impinge a particle in a flow channel of a cytometer. The light leaving the flow channel may be sensed by a detector and the light distinguished according to wavelength.
PCT/US2005/031493 2004-09-01 2005-09-01 Frequency-multiplexed detection of multiple wavelength light for flow cytometry WO2006026766A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05794052.0A EP1784630B1 (en) 2004-09-01 2005-09-01 Frequency-multiplexed detection of multiple wavelength light for flow cytometry
CN2005800366981A CN101052867B (en) 2004-09-01 2005-09-01 Frequency-multiplexed detection of multiple wavelength light for flow cytometry
JP2007530436A JP2008511843A (en) 2004-09-01 2005-09-01 Frequency multiplexed detection of multiwavelength light for flow cytometry.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/931,686 US7612871B2 (en) 2004-09-01 2004-09-01 Frequency-multiplexed detection of multiple wavelength light for flow cytometry
US10/931,686 2004-09-01

Publications (2)

Publication Number Publication Date
WO2006026766A2 WO2006026766A2 (en) 2006-03-09
WO2006026766A3 true WO2006026766A3 (en) 2006-06-01

Family

ID=35429242

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/031493 WO2006026766A2 (en) 2004-09-01 2005-09-01 Frequency-multiplexed detection of multiple wavelength light for flow cytometry

Country Status (5)

Country Link
US (1) US7612871B2 (en)
EP (1) EP1784630B1 (en)
JP (2) JP2008511843A (en)
CN (1) CN101052867B (en)
WO (1) WO2006026766A2 (en)

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US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
WO2012036794A2 (en) * 2010-08-01 2012-03-22 Array Optronix, Inc. Photodetectors with light incident surface and contact surface and applications thereof
CN102288531B (en) * 2011-04-21 2012-12-19 西北工业大学 Method and device for filtering, dyeing and counting cells
PL3521810T3 (en) * 2018-01-31 2020-05-18 Sick Engineering Gmbh Analyser for the determination of fine dust
CN114152559A (en) * 2021-12-13 2022-03-08 常州必达科生物科技有限公司 Light spot detection method and device
CN114324205A (en) * 2021-12-16 2022-04-12 赛默飞世尔（上海）仪器有限公司 Method and system for performing spectrometry on sample and flow cytometer

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Also Published As

Publication number Publication date
EP1784630A2 (en) 2007-05-16
WO2006026766A2 (en) 2006-03-09
EP1784630B1 (en) 2018-05-30
JP2008511843A (en) 2008-04-17
JP2011059127A (en) 2011-03-24
CN101052867B (en) 2012-05-02
JP5762720B2 (en) 2015-08-12
CN101052867A (en) 2007-10-10
US20060051096A1 (en) 2006-03-09
US7612871B2 (en) 2009-11-03

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