WO2006030043A1 - System for detecting the presence of hyperactive cell accumulations in an animal organism and associated detection method - Google Patents

System for detecting the presence of hyperactive cell accumulations in an animal organism and associated detection method Download PDF

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Publication number
WO2006030043A1
WO2006030043A1 PCT/ES2005/000436 ES2005000436W WO2006030043A1 WO 2006030043 A1 WO2006030043 A1 WO 2006030043A1 ES 2005000436 W ES2005000436 W ES 2005000436W WO 2006030043 A1 WO2006030043 A1 WO 2006030043A1
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Prior art keywords
animal organism
detection
cell accumulations
contrast agent
magnetic field
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PCT/ES2005/000436
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Spanish (es)
French (fr)
Inventor
Daniel Serrano Gil
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Daniel Serrano Gil
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Publication of WO2006030043A1 publication Critical patent/WO2006030043A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/0522—Magnetic induction tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient

Definitions

  • the invention relates to an arrangement and method for detecting the presence in an animal organism of highly active cell accumulations with uncontrolled cell proliferation, which are a consequence of a tumor process.
  • the scope of the invention is the field of preventive medicine in the detection of overactive cell accumulations, although without referring to a medical diagnostic process as such.
  • Cancer is a disease whose early detection is vital for the survival and healing of the patient.
  • the non-detection of the disease allows the metastasis of the malignant tumors and thus the tumor tissue cells separate from it moving through the body through the lymphatic system or the circulatory system, depending on the type of tumor and its location, until they find an appropriate place of the organism in which they are fixed to begin their division, thus creating tumors in multiple places of the body that can give rise to new metastases and new tumors.
  • These cells lack another functional activity that is not to divide constantly, therefore, when they affect a vital organ they manage to supplant the organic tissue but without performing the functions of the original tissue; With this, as the tumor increases in size, the affected person begins to have organic difficulties. Normally when the first symptoms of the disease are Appreciable by the affected is already late, and the life expectancy is very short. It is easy to conclude that those affected by cancer die because the development of the tumor or its metastasis eventually destroys the vital organs damaged
  • metastasis depending on the type of tumor in question, occurs in a primary phase of the tumor or in a more advanced phase.
  • Skin tumors usually produce metastases rapidly, while in other types of tumors metastasis occurs when the tumor is more developed. Therefore, early detection of any type of malignant tumor is vital because, normally, when the disease shows symptoms, metastasis exists and the disease is practically irreversible.
  • CT computerized axial tomography
  • NMR nuclear magnetic resonance
  • PET positron emission tomography
  • Another purpose of the invention relates to the process a continue to reach the detection of hyperactive cell accumulations in an animal organism, to record the data obtained and its situation in the individual, to the object, if applicable, of its subsequent evaluation through a medical diagnosis.
  • the detection of an abnormal accumulation of iron oxide present in a contrast agent introduced somewhere in an animal organism provides for a very high sensitivity electromagnetic emitter and receiver suitable for creating a homogeneous magnetic field. distortible in the presence of the contrast agent, with acquisition and maintenance costs .sensibly lower than those of an MRI apparatus, for example.
  • said very high sensitivity electromagnetic emitter and receiver are transported by means of a parallel guided frame on a support table, stretcher or the like in which the patient is laid, so that a first and second sweeps of the patient can be performed.
  • lying body The electromagnetic emitter that generates the magnetic field is located in the upper part of the frame, while in the lower part of the frame, provided below the support table, the electromagnetic receiver is conveniently located opposite the emitter.
  • a digital camera is conveniently arranged in a column fixed to one side of the support table.
  • the support table comprises a protective screen that separates, from the patient, a work surface that includes at least one microprocessor connected to a keyboard and a monitor suitable for the capture, memorization and evaluation of magnetic field alterations as well as for enable the output of data for printing the records obtained on the digital image achieved with the digital camera and previously inserted into the microprocessor.
  • the frame that carries the electromagnetic emitter and receiver moves, both longitudinally and transversely, on the support table in order to perform a first scan on the patient.
  • Said first scan allows to detect, before the administration of the contrast agent, any metallic object that the patient has embedded in the body. This first detection is captured, memorized and evaluated in the microprocessor to be dismissed.
  • a second sweep over his body detects the distortion caused in the homogeneous electromagnetic field generated by the anomalous accumulation of iron that is thus transferred to the microprocessor for its memorization, evaluation and positioning on the Digital image taken with the digital camera.
  • the method for the detection of highly active cell accumulations comprises the following steps:
  • d) carry out a second scan of the patient's body by means of the emitter and an electromagnetic receiver and memorize, if it occurs, the alteration of the magnetic field of the detector, which can be notified by, for example, an acoustic or luminous signal, or both to the time
  • the single figure shows, by isometric perspective, a simplified embodiment of a practical example of the arrangement for detecting the presence of hyperactive cell accumulations in an animal organism.
  • the arrangement for detecting the presence of highly active cell accumulations in an animal organism comprises a support table (1) provided laterally of guide rails (2) that use the frame (3) in the transmitter carrier C in its displacement
  • the protective screen (6) separates a workstation that incorporates a microprocessor (7) connected to a keyboard (8) and a monitor (9), which constitute the means for capturing , memorization and evaluation of the alterations of the magnetic field and enable through a printer (not shown) the printing of the records obtained on the digital image obtained with the digital camera (10) that incorporates the column (11), conveniently arranged on the support table (1).
  • a microprocessor (7) connected to a keyboard (8) and a monitor (9), which constitute the means for capturing , memorization and evaluation of the alterations of the magnetic field and enable through a printer (not shown) the printing of the records obtained on the digital image obtained with the digital camera (10) that incorporates the column (11), conveniently arranged on the support table (1).
  • the procedure for the detection of cell accumulations of great activity with uncontrolled cell proliferation begins, once the patient is lying on the support table (1), with the photographic snapshot made using the digital camera ( 10) and subsequently stored in the microprocessor (7), connected to the keyboard
  • the frame (3) is now moved, guided in the guide rails (2) of the support table (1), sweeping the patient's body, while between the emitter (4) and receiver
  • the frame (3) performs a second scan on it, while the homogeneous magnetic field is created between the emitter (4) and the receiver (5).
  • the distortion of the created magnetic field produced before the anomalous accumulation of ferric metal in the organism, is detected by the field sensors connected to the emitter (4) and the receiver (5) to be transferred to the microprocessor (7).
  • the final data recorded in the internal memory of the microprocessor (7) and on the digital photograph taken, allow its visualization and printing, or any other subsequent handling, by conventional means for the medical evaluation of the patient.

Abstract

The invention relates to a system for detecting the presence of highly-active cell accumulations in an animal organism. The inventive system consists of a support table (1) comprising lateral guide rails (2) for the movement of a frame (3) bearing a transmitter (4) and a receiver (5) between which a magnetic field is created, whereby resulting distortions are detected by field sensors that are connected to the transmitted and receiver prior to the anomalous presence of ferrous metal in the organism.

Description

DISPOSICIÓN PARA DETECTAR LA PRESENCIA DE ACUMULACIONES CELULARES HIPERACTÍVAS EN UN ORGANISMO ANIMAL Y PROCEDIMIENTO EMPLEADO EN LA DETECCIÓNPROVISION TO DETECT THE PRESENCE OF HYPERACTIVE CELLULAR ACCUMULATIONS IN AN ANIMAL ORGANISM AND PROCEDURE USED IN THE DETECTION
SECTOR DE LA TÉCNICASECTOR OF THE TECHNIQUE
La invención se refiere a una disposición y procedimiento que permiten detectar la presencia en un organismo animal de acumulaciones celulares de gran actividad con proliferación celular incontrolada, que son consecuencia de un proceso tumoral.The invention relates to an arrangement and method for detecting the presence in an animal organism of highly active cell accumulations with uncontrolled cell proliferation, which are a consequence of a tumor process.
El ámbito de aplicación de la invención es el campo de la medicina preventiva en la detección de acumulaciones celulares hiperactivas, aunque sin referirse a un proceso diagnóstico médico como tal.The scope of the invention is the field of preventive medicine in the detection of overactive cell accumulations, although without referring to a medical diagnostic process as such.
ESTADO ANTERIOR DE LA TÉCNICAPREVIOUS STATE OF THE TECHNIQUE
El cáncer es una enfermedad cuya detección precoz resulta vital para la supervivencia y curación del paciente. La no detección de la enfermedad, en sus comienzos, permite la metástasis de los tumores malignos y asi las células del tejido tumoral se separan de éste desplazándose a través del cuerpo por el sistema linfático o por el circulatorio, según el tipo de tumor y su localización, hasta que encuentran un lugar apropiado del organismo en el que se fijan para comenzar su división, creando asi tumores en múltiples lugares del cuerpo que pueden dar lugar a nuevas metástasis y nuevos tumores. Estas células carecen de otra actividad funcional que no sea la de dividirse constantemente, por tanto, cuando afectan a un órgano vital logran suplantar al tejido orgánico aunque sin realizar las funciones del tejido original; con ello, a medida que el tumor va aumentando de tamaño el afectado comienza a tener dificultades orgánicas. Normalmente cuando los primeros síntomas de la enfermedad son apreciables por el afectado ya es tarde, y la esperanza de vida muy corta. Es fácil concluir en que los afectados de cáncer fallecen porque el desarrollo del tumor o su metástasis terminan por destruir los órganos vitales dañadosCancer is a disease whose early detection is vital for the survival and healing of the patient. The non-detection of the disease, in its beginnings, allows the metastasis of the malignant tumors and thus the tumor tissue cells separate from it moving through the body through the lymphatic system or the circulatory system, depending on the type of tumor and its location, until they find an appropriate place of the organism in which they are fixed to begin their division, thus creating tumors in multiple places of the body that can give rise to new metastases and new tumors. These cells lack another functional activity that is not to divide constantly, therefore, when they affect a vital organ they manage to supplant the organic tissue but without performing the functions of the original tissue; With this, as the tumor increases in size, the affected person begins to have organic difficulties. Normally when the first symptoms of the disease are Appreciable by the affected is already late, and the life expectancy is very short. It is easy to conclude that those affected by cancer die because the development of the tumor or its metastasis eventually destroys the vital organs damaged
Es sabido que la metástasis, dependiendo del tipo de tumor de que se trate, se produce en una fase primaria del tumor o bien en fase más avanzada. Los tumores de piel suelen producir metástasis rápidamente, mientras que en otro tipo de tumores la metástasis se produce cuando el tumor se encuentra más desarrollado. Por tanto, es vital la detección precoz de cualquier tipo de tumor maligno pues, normalmente, cuando la enfermedad muestra síntomas la metástasis existe y la enfermedad es prácticamente irreversible.It is known that metastasis, depending on the type of tumor in question, occurs in a primary phase of the tumor or in a more advanced phase. Skin tumors usually produce metastases rapidly, while in other types of tumors metastasis occurs when the tumor is more developed. Therefore, early detection of any type of malignant tumor is vital because, normally, when the disease shows symptoms, metastasis exists and the disease is practically irreversible.
En los últimos años han sido desarrolladas técnicas para el diagnostico médico que permiten ver, de manera no invasora, el interior de un organismo animal. Asi, por ejemplo, la tomografia axial computerizada (TAC) permite obtener, en distintos planos de detección alrededor del paciente, una imagen tridimensional más rica en información que las placas simples de rayos X. Una técnica más reciente de diagnostico no invasor, como es la resonancia magnética nuclear (RMN) , muestra la distribución de agua en el cuerpo humano al excitar en un potente campo magnético los protones de los átomos de hidrógeno que giran alrededor de la dirección del campo emitiendo ondas de radio, que se registran y analizan mediante un microprocesador, que produce finalmente una sección en dos dimensiones del cuerpo humano. Aún más recientemente, la tomografia por emisión de positrones (TEP) , emitidos por un isótopo introducido en el paciente a través de la glucosa que le es suministrada y aniquilados tras su encuentro con los electrones presentes en la materia, distingue entre tejido enfermo y sano, revelando además la presencia de metástasis adicionales y detectando todas las lesiones tumorales en una sola exploración. Sin embargo, aunque estas técnicas de diagnostico resultan de una gran precisión en la detección de tumores de poco tamaño, presentan limitaciones e inconvenientes que impiden su utilización preventiva como detectores precoces de la enfermedad. Los pocos aparatos de que disponen, tanto la sanidad pública como la privada, debido al altísimo coste que supone su adquisición y mantenimiento y las largas listas de espera a que están sometidos los posibles afectados para ser sometidos a las pertinentes pruebas, hacen inviable su uso preventivo.In recent years, techniques for medical diagnosis have been developed that allow to see, in a non-invasive way, the interior of an animal organism. Thus, for example, computerized axial tomography (CT) allows obtaining, in different detection planes around the patient, a three-dimensional image richer in information than simple x-ray plates. A more recent non-invasive diagnostic technique, such as nuclear magnetic resonance (NMR), shows the distribution of water in the human body by exciting in a powerful magnetic field the protons of hydrogen atoms that rotate around the direction of the field emitting radio waves, which are recorded and analyzed by a microprocessor, which finally produces a two-dimensional section of the human body. Even more recently, positron emission tomography (PET), emitted by an isotope introduced into the patient through the glucose supplied to it and annihilated after its encounter with the electrons present in the matter, distinguishes between diseased and healthy tissue. , also revealing the presence of additional metastases and detecting all tumor lesions in a single examination. However, although these diagnostic techniques are highly accurate in the detection of small tumors, they have limitations and disadvantages that prevent their preventive use as early detectors of the disease. The few devices available to them, both public and private health, due to the high cost of their acquisition and maintenance and the long waiting lists to which those affected are subjected to be subjected to the relevant tests, make their use unfeasible. preventive.
Existe, por tanto, una necesidad no cubierta en el sistema sanitario, en lo que se refiere a la detección precoz del cáncer de manera sencilla, rápida y con un bajo costo, pues no se conoce técnica o aparato adecuado para ello. Asi es obvia, para cubrir una necesidad imperiosa del sistema sanitario y poder evitar un gran número de muertes por la tardía detección de un proceso cancerígeno, la incorporación de un dispositivo que sea capaz de detectar la presencia de acumulaciones celulares hiperactivas en un organismo animal, de fácil y rápida utilización que además resulte de bajo costo de adquisición y mantenimiento, a fin de hacer masiva su presencia en hospitales, clínicas, consultas médicas u otros establecimientos.There is, therefore, a need not covered in the health system, in regard to the early detection of cancer in a simple, fast and low-cost way, since no suitable technique or apparatus is known for it. Thus it is obvious, to cover an urgent need of the health system and to avoid a large number of deaths due to the late detection of a carcinogenic process, the incorporation of a device that is capable of detecting the presence of hyperactive cell accumulations in an animal organism, of easy and fast use that also results in low cost of acquisition and maintenance, in order to make its presence massive in hospitals, clinics, medical consultations or other establishments.
OBJETO DE LA INVENCIÓNOBJECT OF THE INVENTION
Es un propósito de la invención la construcción de una disposición sencilla y eficaz que permita detectar de forma económica las acumulaciones celulares hiperactivas en un organismo animal cuando la presencia de un marcador en ellas distorsiona un campo electromagnético homogéneo creado entre un emisor y un receptor electromagnéticos.It is a purpose of the invention to construct a simple and efficient arrangement that allows to detect in an economic way the overactive cellular accumulations in an animal organism when the presence of a marker in them distorts a homogeneous electromagnetic field created between an emitter and an electromagnetic receiver.
Otro propósito de la invención se refiere al procedimiento a seguir para llegar a la detección de las acumulaciones celulares hiperactivas en un organismo animal, para registrar los datos obtenidos y su situación en el individuo, al objeto, si es el caso, de su evaluación posterior a través de un diagnostico médico.Another purpose of the invention relates to the process a continue to reach the detection of hyperactive cell accumulations in an animal organism, to record the data obtained and its situation in the individual, to the object, if applicable, of its subsequent evaluation through a medical diagnosis.
DESCRIPCIÓN DE IA INVENCIÓNDESCRIPTION OF THE INVENTION
De acuerdo con el invento, la detección de una acumulación anormal de oxido de hierro presente en un agente de contraste introducido en alguna parte de un organismo animal prevé un emisor y un receptor electromagnéticos de muy alta sensibili¬ dad aptos para crear un campo magnético homogéneo distorsio- nable en presencia del agente de contraste, con unos costos de adquisición y mantenimiento .sensiblemente inferiores a los de un aparato de resonancia magnética, por ejemplo.According to the invention, the detection of an abnormal accumulation of iron oxide present in a contrast agent introduced somewhere in an animal organism provides for a very high sensitivity electromagnetic emitter and receiver suitable for creating a homogeneous magnetic field. distortible in the presence of the contrast agent, with acquisition and maintenance costs .sensibly lower than those of an MRI apparatus, for example.
Según el invento, dichos emisor y receptor electromagnéticos de muy alta sensibilidad son transportados mediante un bastidor guiado paralelo sobre una mesa de soporte , camilla o similar en la que se tiende el paciente, de manera que puedan ser realizados un primer y un segundo barridos del cuerpo tendido. En la parte superior del bastidor está situado el emisor electromagnético que genera el campo magnético, en tanto que en la parte inferior del bastidor, prevista por debajo de la mesa de soporte, es convenientemente situado, enfrentado al emisor, el receptor electromagnético. Una cámara fotográfica digital está convenientemente dispuesta en una columna fijada a un lateral de la mesa de soporte.According to the invention, said very high sensitivity electromagnetic emitter and receiver are transported by means of a parallel guided frame on a support table, stretcher or the like in which the patient is laid, so that a first and second sweeps of the patient can be performed. lying body The electromagnetic emitter that generates the magnetic field is located in the upper part of the frame, while in the lower part of the frame, provided below the support table, the electromagnetic receiver is conveniently located opposite the emitter. A digital camera is conveniently arranged in a column fixed to one side of the support table.
La mesa de soporte comprende una pantalla protectora que separa, del paciente, una superficie de trabajo que incluye al menos un microprocesador conectado a un teclado y a un monitor aptos para la captación, memorización y evaluación de las alteraciones del campo magnético asi como para posibilitar la salida de datos para la impresión de los registros obtenidos sobre la imagen digital lograda con la cámara fotográfica digital y previamente introducida en el microprocesador.The support table comprises a protective screen that separates, from the patient, a work surface that includes at least one microprocessor connected to a keyboard and a monitor suitable for the capture, memorization and evaluation of magnetic field alterations as well as for enable the output of data for printing the records obtained on the digital image achieved with the digital camera and previously inserted into the microprocessor.
El bastidor que transporta al emisor y al receptor electromagnéticos se mueve, tanto longitudinal como transversalmente, sobre la mesa de soporte a fin de efectuar un primer barrido sobre el paciente. Dicho primer barrido permite detectar, antes de la administración del agente de contraste, cualquier objeto metálico que el paciente tenga incrustado en el cuerpo. Esta primera detección es captada, memorizada y evaluada en el microprocesador para ser desestimada. Tras la administración y absorción del agente de contraste por el paciente, un segundo barrido sobre su cuerpo detecta la distorsión provocada en el campo electromagnético homogéneo generado por la acumulación anómala del hierro que asi es trasladada al microprocesador para su memorización, evaluación y posicionamiento sobre la imagen digital tomada con la cámara digital. Impreso el registro, mostrando la localización de las acumulaciones de hierro anómalas, si existen, en la imagen digital obtenida, la detección permite ser diagnosticada y confirmada mediante, por ejemplo una RMN o un TAC.The frame that carries the electromagnetic emitter and receiver moves, both longitudinally and transversely, on the support table in order to perform a first scan on the patient. Said first scan allows to detect, before the administration of the contrast agent, any metallic object that the patient has embedded in the body. This first detection is captured, memorized and evaluated in the microprocessor to be dismissed. After administration and absorption of the contrast agent by the patient, a second sweep over his body detects the distortion caused in the homogeneous electromagnetic field generated by the anomalous accumulation of iron that is thus transferred to the microprocessor for its memorization, evaluation and positioning on the Digital image taken with the digital camera. Printed the record, showing the location of anomalous iron accumulations, if they exist, in the digital image obtained, the detection can be diagnosed and confirmed by, for example, an NMR or a CT scan.
Evidentemente, esta técnica debe ser vigilada o desestimada cuando su utilización en el paciente pueda conducir a resultados erróneos o concurran en éste factores que la hagan desaconsejable: pacientes con implantaciones electromecánicas (marcapasos, válvulas cardiacas, etc.) o alérgicos al agente de contraste.Obviously, this technique must be monitored or dismissed when its use in the patient can lead to erroneous results or factors that make it inadvisable: patients with electromechanical implants (pacemakers, heart valves, etc.) or allergic to the contrast agent.
Sustancialmente según el invento, el procedimiento para la detección de acumulaciones celulares de gran actividad comprende las siguientes etapas:Substantially according to the invention, the method for the detection of highly active cell accumulations comprises the following steps:
a) realizar una fotografía digital al paciente que se memoriza en un ordenador;a) take a digital photograph of the patient who memorize on a computer;
b) efectuar un primer barrido del cuerpo del paciente mediante un emisor y un receptor electromagnéticos y memorizar, si se produce, la alteración del campo magnético del detector, que puede ser avisada mediante, por ejemplo, una señal acústica o luminosa, o ambas a la vez;b) perform a first scan of the patient's body by means of an electromagnetic emitter and receiver and memorize, if it occurs, the alteration of the magnetic field of the detector, which can be notified by, for example, an acoustic or luminous signal, or both a the time
c) administrar al paciente un agente de contraste, esperar a la absorción del agente de contraste en las células anómalas y a la acumulación de moléculas férricas;c) administer a contrast agent to the patient, wait for the absorption of the contrast agent in the abnormal cells and the accumulation of ferric molecules;
d) efectuar un segundo barrido del cuerpo del paciente mediante el emisor y un receptor electromagnéticos y memorizar, si se produce, la alteración del campo magnético del detector, que puede ser avisada mediante, por ejemplo, una señal acústica o luminosa, o ambas a la vez;d) carry out a second scan of the patient's body by means of the emitter and an electromagnetic receiver and memorize, if it occurs, the alteration of the magnetic field of the detector, which can be notified by, for example, an acoustic or luminous signal, or both to the time
e) emitir un informe del registro que muestre la o las alteraciones magnéticas memorizadas y su situación en la fotografia digital tomada.e) issue a record report that shows the memorized magnetic alteration (s) and their situation in the digital photo taken.
BREVE DESCRIPCIÓN DE LOS DIBUJOSBRIEF DESCRIPTION OF THE DRAWINGS
Al objeto de facilitar mejor comprensión de lo ya expuesto, la descripción es completada con un juego de dibujos que muestran una realización preferida por la disposición que se preconiza, realización que no debiera ser considerada limitativa de las características peculiares de la solicitud que se formula.In order to facilitate a better understanding of the above, the description is completed with a set of drawings that show a preferred embodiment for the provision that is recommended, an embodiment that should not be considered as limiting the peculiar characteristics of the request made.
La figura única muestra, mediante perspectiva isométrica, una realización simplificada de un ejemplo práctico de la disposición para detectar la presencia de acumulaciones celulares hiperactivas en un organismo animal.The single figure shows, by isometric perspective, a simplified embodiment of a practical example of the arrangement for detecting the presence of hyperactive cell accumulations in an animal organism.
REALIZACIÓN PREFERIDA DE LA INVENCIÓN De acuerdo con el invento y según se aprecia en la figura que muestra la hoja de dibujos que se acompaña, la disposición para detectar la presencia de acumulaciones celulares de gran actividad en un organismo animal comprende una mesa de sopor¬ te (1) provista lateralmente de carriles de guia (2) que usa en su desplazamiento el bastidor (3) en C portador del emisorPREFERRED EMBODIMENT OF THE INVENTION According to the invention and as seen in the figure showing the accompanying drawing sheet, the arrangement for detecting the presence of highly active cell accumulations in an animal organism comprises a support table (1) provided laterally of guide rails (2) that use the frame (3) in the transmitter carrier C in its displacement
(4) y del receptor (5) electromagnéticos, cuyas distorsiones son detectadas por' los sensores de campo a ellos conectados ante la presencia anómala de metal férrico en el organismo.(4) and the electromagnetic receiver (5), whose distortions are detected by ' the field sensors connected to them in the presence of anomalous ferric metal in the organism.
En la mesa de soporte (1) , la pantalla protectora (6) separa un puesto de trabajo que incorpora un microprocesador (7) conectado a un teclado (8) y a un monitor (9), que constitu- yen los medios para la captación, memorización y evaluación de las alteraciones del campo magnético y posibilitan a través de una impresora (no representada) la impresión de los registros obtenidos sobre la imagen digital obtenida con la cámara fotográfica digital (10) que incorpora la columna (11) , convenientemente dispuesta en la mesa de soporte (1) .On the support table (1), the protective screen (6) separates a workstation that incorporates a microprocessor (7) connected to a keyboard (8) and a monitor (9), which constitute the means for capturing , memorization and evaluation of the alterations of the magnetic field and enable through a printer (not shown) the printing of the records obtained on the digital image obtained with the digital camera (10) that incorporates the column (11), conveniently arranged on the support table (1).
Según lo dicho, el procedimiento para la detección de acumu¬ laciones celulares de gran actividad con proliferación celu¬ lar incontrolada comienza, una vez tumbado el paciente en la mesa de soporte (1) , con la instantánea fotográfica realizada mediante la cámara fotográfica digital (10) y memorizada con posterioridad en el microprocesador (7) , conectado al tecladoAs said, the procedure for the detection of cell accumulations of great activity with uncontrolled cell proliferation begins, once the patient is lying on the support table (1), with the photographic snapshot made using the digital camera ( 10) and subsequently stored in the microprocessor (7), connected to the keyboard
(8) y al monitor (9) y separados del paciente, en la mesa de soporte (1), por la pantalla protectora (6) . El bastidor (3) es ahora desplazado, guiado en los carriles de guia (2) de la mesa de soporte (1), barriendo el cuerpo del paciente, en tanto que, entre el emisor (4) y receptor(8) and the monitor (9) and separated from the patient, on the support table (1), by the protective screen (6). The frame (3) is now moved, guided in the guide rails (2) of the support table (1), sweeping the patient's body, while between the emitter (4) and receiver
(5) que aquel porta es creado el campo magnético homogéneo que se pretende. En el supuesto de que existan alteraciones del campo magnético creado, éstas serán registradas en el microprocesador (7) para su comparación posterior. Administrado el agente de contraste y una vez absorbido por el paciente, el bastidor (3) efectúa un segundo barrido sobre éste, mientras es creado el campo magnético homogéneo entre el emisor (4) y el receptor (5) . La distorsión del campo magnético creado, producida ante la acumulación anómala de metal férrico en el organismo, es detectada por los sensores de campo conectados al emisor (4) y al receptor (5) para ser trasladado al microprocesador (7) . Los datos finales, registrados en la memoria interna del microprocesador (7) y sobre la fotografía digital tomada, permiten su visualización e impresión, o cualquier otro manejo ulterior, por medios convencionales para la evaluación médica del paciente. (5) that that portal is created the homogeneous magnetic field that is intended. In the event that there are alterations of the magnetic field created, these will be recorded in the microprocessor (7) for later comparison. Once the contrast agent is administered and once absorbed by the patient, the frame (3) performs a second scan on it, while the homogeneous magnetic field is created between the emitter (4) and the receiver (5). The distortion of the created magnetic field, produced before the anomalous accumulation of ferric metal in the organism, is detected by the field sensors connected to the emitter (4) and the receiver (5) to be transferred to the microprocessor (7). The final data, recorded in the internal memory of the microprocessor (7) and on the digital photograph taken, allow its visualization and printing, or any other subsequent handling, by conventional means for the medical evaluation of the patient.

Claims

REIVINDICACIONES
1. Disposición para detectar la presencia de acumulaciones celulares hiperactivas en un organismo animal y procedimiento empleado en la detección, que utiliza un agente de contraste introducido en un organismo animal y un medio para la deter¬ minación de la posición del agente de contraste, caracteriza¬ do por el hecho de que prevé un emisor (4) y un receptor (5) electromagnéticos, portados en un bastidor (3) montado sobre guias (2) en una mesa de soporte (1), a fin de crear un campo magnético sensiblemente homogéneo que puede ser alterado por la presencia en el campo de dicho agente de contraste.1. Provision to detect the presence of hyperactive cell accumulations in an animal organism and procedure used in the detection, which uses a contrast agent introduced into an animal organism and a means for determining the position of the contrast agent, characterizes ¬ Doing the fact that it provides an electromagnetic emitter (4) and a receiver (5), carried on a frame (3) mounted on guides (2) on a support table (1), in order to create a magnetic field substantially homogeneous that can be altered by the presence in the field of said contrast agent.
2. Disposición para detectar la presencia de acumulaciones celulares hiperactivas en un organismo animal y procedimiento empleado en la detección, según reivindicación 1, caracteri¬ zado porque dicho bastidor (3) comprende sensores del campo magnético conectados al emisor (4) y al receptor (5) , y con ellos previstos por arriba y por debajo de la mesa (1), que miden las alteraciones producidas en dicho campo magnético sensiblemente homogéneo por la presencia del agente de contraste magnetizable.2. Arrangement for detecting the presence of hyperactive cell accumulations in an animal organism and method used in the detection, according to claim 1, characterized in that said frame (3) comprises magnetic field sensors connected to the emitter (4) and the receiver ( 5), and with them provided above and below the table (1), which measure the alterations produced in said magnetic field substantially homogeneous by the presence of the magnetizable contrast agent.
3. Disposición para detectar la presencia de acumulaciones celulares hiperactivas en un organismo animal y procedimiento empleado en la detección, según reivindicación 1, caracteri¬ zado porque la disposición prevé medios (7, 8, 9) para la captación, memorización y evaluación de las alteraciones e impresión de su registro.3. Provision to detect the presence of hyperactive cell accumulations in an animal organism and method used in the detection, according to claim 1, characterized in that the provision provides means (7, 8, 9) for the collection, memorization and evaluation of the Alterations and printing of your record.
4. Disposición para detectar la presencia de acumulaciones celulares hiperactivas en un organismo animal y procedimiento empleado en la detección, según reivindicación 1, caracteri¬ zado porque la disposición prevé una cámara fotográfica digi- tal (10) en conexión con dichos medios de registro (7, 8, 9) .4. Provision for detecting the presence of hyperactive cell accumulations in an animal organism and method used in the detection, according to claim 1, characterized in that the arrangement provides for a digital camera (10) in connection with said recording means ( 7, 8, 9).
HOJADE SUSTITUCIÓN (REGLA26) SUBSTITUTE SHEET (RULE 26)
5. Procedimiento empleado en la detección de acumulaciones celulares hiperactivas en un organismo animal, caracterizado porque comprende realizar una fotografía digital al paciente que se memoriza en el microprocesador (7) .5. Procedure used in the detection of hyperactive cell accumulations in an animal organism, characterized in that it comprises taking a digital photograph of the patient stored in the microprocessor (7).
6. Procedimiento empleado en la detección de acumulaciones celulares hiperactivas en un organismo animal, según reivindicaciones anteriores, caracterizado porque comprende efectuar un primer barrido del cuerpo del paciente mediante un emisor (4) y un receptor (5) electromagnéticos y memori- zar, si se produce, la alteración del campo magnético, que puede ser avisada mediante, por ejemplo, una señal acústica o luminosa, o ambas a la vez.6. Method used in the detection of hyperactive cell accumulations in an animal organism, according to previous claims, characterized in that it comprises performing a first scan of the patient's body by means of an emitter (4) and an electromagnetic receiver (5) and memorizing, if occurs, the alteration of the magnetic field, which can be notified by, for example, an acoustic or luminous signal, or both at the same time.
7. Procedimiento empleado en la detección de acumulaciones celulares hiperactivas en un organismo animal, según reivindicaciones anteriores, caracterizado porque comprende administrar al paciente un agente de contraste, esperar a la absorción del agente de contraste en las células anómalas y a la acumulación de moléculas férricas.7. Method used in the detection of hyperactive cell accumulations in an animal organism, according to previous claims, characterized in that it comprises administering to the patient a contrast agent, waiting for the absorption of the contrast agent in the anomalous cells and the accumulation of ferric molecules.
8. Procedimiento empleado en la detección de acumulaciones celulares hiperactivas en un organismo animal, según reivindicaciones anteriores, caracterizado porque comprende efectuar un segundo barrido del cuerpo del paciente mediante el emisor (4) y el receptor (5) electromagnéticos y memori- zar, si se produce, la alteración del campo magnético, que puede ser avisada mediante, por ejemplo, una señal acústica o luminosa, o ambas a la vez.8. Method used in the detection of hyperactive cell accumulations in an animal organism, according to previous claims, characterized in that it comprises performing a second scan of the patient's body by means of the emitter (4) and the electromagnetic receiver (5) and memorizing, if occurs, the alteration of the magnetic field, which can be notified by, for example, an acoustic or luminous signal, or both at the same time.
9. Procedimiento empleado en la detección de acumulaciones celulares hiperactivas en un organismo animal, según reivin¬ dicaciones anteriores, caracterizado porque comprende emitir un informe del registro que muestre las alteraciones magnéti- cas memorizadas y su situación en la fotografía tomada.9. Procedure used in the detection of hyperactive cell accumulations in an animal organism, according to previous claims, characterized in that it comprises issuing a record report showing the memorized magnetic alterations and their situation in the picture taken.
HOJADESUSTITUCIÓN (REGLA26) SUBSTITUTE SHEETS (RULE 26)
PCT/ES2005/000436 2004-08-06 2005-07-29 System for detecting the presence of hyperactive cell accumulations in an animal organism and associated detection method WO2006030043A1 (en)

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ESP200401978 2004-08-06
ES200401978A ES2255830B1 (en) 2004-08-06 2004-08-06 PROVISION TO DETECT THE PRESENCE OF HYPERACTIVE CELLULAR ACCUMULATIONS IN AN ANIMAL ORGANISM AND PROCEDURE USED IN THE DETECTION.

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