WO2006031899A2 - Intraluminal electrode assembly - Google Patents

Intraluminal electrode assembly Download PDF

Info

Publication number
WO2006031899A2
WO2006031899A2 PCT/US2005/032765 US2005032765W WO2006031899A2 WO 2006031899 A2 WO2006031899 A2 WO 2006031899A2 US 2005032765 W US2005032765 W US 2005032765W WO 2006031899 A2 WO2006031899 A2 WO 2006031899A2
Authority
WO
WIPO (PCT)
Prior art keywords
wires
electrode assembly
housing
cannulated tube
electrical contacts
Prior art date
Application number
PCT/US2005/032765
Other languages
French (fr)
Other versions
WO2006031899A3 (en
Inventor
Andre Machado
Ali Rezai
Original Assignee
The Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Cleveland Clinic Foundation filed Critical The Cleveland Clinic Foundation
Priority to EP05797614A priority Critical patent/EP1804902A4/en
Publication of WO2006031899A2 publication Critical patent/WO2006031899A2/en
Publication of WO2006031899A3 publication Critical patent/WO2006031899A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/029—Measuring or recording blood output from the heart, e.g. minute volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0558—Anchoring or fixation means therefor

Definitions

  • the present invention is directed to an expandable intraluminal electrode assembly.
  • Neuromodulation which involves delivering electrical impulses to neural target sites, has become an important therapeutic method and is an option when other forms of treatment, such as drug administration, are ineffective.
  • Neuromodulation has revolutionized the treatment of several neurological disorders, such as movement disorders and chronic pain and has been described in U.S. Patent No. 6885,888 for treating heart contractility.
  • Technical and mechanical limitations create obstacles to the final application of such methods in patients. For example, one obstacle is in the invasive nature of neuromodulation, which requires open surgery.
  • the present invention provides an intraluminal electrode assembly comprising a cannulated tube and a plurality of wires disposed in the cannulated tube.
  • Each of the plurality of wires has one of a plurality of electrical contacts at a distal end thereof.
  • the plurality of wir p s assumes a radially constrgined configuration within the cannulated tube in a retracted position and a radially extended configuration outward of the cannulated tube in a deployed position.
  • the electrode assembly further comprises a spring wire connecting the plurality of electrical contacts together to collectively form a substantially circular configuration in a deployed position.
  • FIG. 1 depicts a perspective view of an embodiment of an intraluminal electrode assembly according to the present invention in a retracted position.
  • FIG. 2 depicts a perspective view of an embodiment of an intraluminal electrode assembly according to the present invention in a deployed position.
  • FIG. 3 depicts an end view of an embodiment of an intraluminal electrode assembly according to the present invention.
  • FIG. 4 depicts a pulmonary artery catheter including an embodiment of an intraluminal electrode assembly according to the present invention.
  • FIG. 5 illustrates a step from an exemplary method of delivering a pulmonary artery catheter including an embodiment of an intraluminal electrode assembly according to the present invention.
  • FIG. 6 illustrates a step after the step illustrated in FIG. 5 from an exemplary method of delivering a pulmonary artery catheter including an embodiment of an intraluminal electrode assembly according to the present invention.
  • the present invention provides an electrode assembly 10 comprising a cannulated tube 20, which can be a catheter, housing a plurality of wires 30.
  • Each of the plurality of wires 30 has one of a plurality of electrical contacts 40 at a distal end thereof.
  • the plurality of wires 30 in a retracted position, assumes a radially constrained configuration within cannulated tube 20.
  • the distal portion of plurality of wires 30 assumes a radially extended configuration outward of cannulated tube 20.
  • a spring wire 50 connects the plurality of electrical contacts 40 (depicted as electrical contacts 40a-40g) together to form a substantially circular configuration in a deployed position.
  • plurality of wires 30, or at least the distal portion of plurality of wires 30 having electrical contacts 40 are fabricated from a shape memory material to allow the distal portion to project concentrically out of cannulated tube 20.
  • other mechanisms for allowing the distal portion of plurality of wires 30 having electrical contacts 40 to project radially outward from cannulated tube 20 can be employed.
  • electrode assembly 10 is not necessarily limited to any particular use, the substantially circular configuration of the distal end of deployed plurality of wires 30 allows electrode assembly 10 to be used for intraluminal purposes, such as transvascular electrical neuromodulation of a target site adjacent to a vessel.
  • electrode assembly 10 can be inserted into a vessel 60 and urged distally forward.
  • plurality of wires 30 can be deployed to project radially outward to reach and contact the walls of vessel 60. Since all the plurality of wires 30 have the same shape, the final resulting vector drives the distal portion of plurality of wires 30 out from cannulated tube 20 to contact the wall of vessel 60.
  • plurality of wires 30 comprises six to eight wires.
  • each of the plurality of electrical contacts 40 of the plurality of wires 30 can be selectively activated such that select electrical contacts 40 on one segment of the arc of the distal end of the plurality of wires 30 can be activated to apply focused electrical signals on a desired side of a vessel.
  • the selective powerability over each electrical contact 40 may be achieved by employing a system including a programmer coupled via a conductor to a telemetry antenna.
  • the programmer is capable of sending signals via the telemetry antenna to control the electrical signal delivered to electrical contacts 40.
  • Such a system permits the selection of various pulse output options after electrode assembly 10 is positioned using telemetry communications.
  • the present, invention als ⁇ o contemplated radio-frequency systems to selectively power electrical contacts 40.
  • the independent powerability of electrical contacts 40 also provides a practitioner with a means of modify or steering the direction and locus of application of electrical signals to precisely target portions of the target region to achieve the desired therapy.
  • electrical contact 40a may be powered to apply an electrical signal to an area adjacent thereto while the signal to electrical contact 4Oe may be substantially minimized to reduce or stop the application of an electrical signal to an area adjacent to electrical contact 4Oe.
  • the locus of stimulation can be selectively adjusted and/or steered in this embodiment of electrode assembly 10, specific areas of the target region can be precisely targeted to achieve the desired therapy.
  • Other or additional means of selectively steering the application of electrical signals may also be utilized in the present invention, such as the methods described in U.S. Patent No. 5,713,922, which is incorporated by reference herein.
  • proximal end of each of the plurality of wires 30 is in communication with rotator 70 at the proximal end of cannulated tube 20 such the distal end of the plurality of wires 30 can be rotated by similar motion of rotator 70.
  • rotator 70 could be a rotary motor or a manual dial that transfers rotational motion from rotator 70 to the distal end of the plurality of wires 30.
  • the present invention also provides an electrode assembly system including electrode assembly 10 and further including components useful in identifying, monitoring, or affecting a target region.
  • a system could include a component for lesioning and temperature monitoring, and/or a component that has a fiberoptic monitor which allows telemetric intracranial monitoring capabilities, and/or a microelectrode recording component, and/or a sensing component to incorporate a feedback mechanism to assist in determining whether electrical contacts 40 should be adjusted.
  • a sensing component a sensor can be incorporated with the electrode assembly system according to the present invention. The sensors can be used with a closed-loop feedback system in order to automatically determine the level of electrical signal to apply to provide the desired therapy.
  • the sensors may be implanted or positioned in or at a portion of the patient's body suitable for detecting characteristics, symptoms or attributes of the condition or disorder being treated, for example, such as electrical brain activity, cerebral blood flow, and/or vital signs or other chemical and electrical activity of the body.
  • Sensors suitable for use in a system according to the present invention include, for example, those disclosed in U.S. Patent No. 5,711,316, which is incorporated by reference herein.
  • stimulating electrodes may be intermittently used to record electrical activity.
  • one or more electrodes implanted or positioned within the brain may serve as a sensor or a recording electrode. When necessary, these sensing or recording electrodes may deliver stimulation therapy to the target region.
  • the output of an external feedback sensor may communicate with a pulse generator through a telemetry down-link.
  • Any sensing functions in accordance with the present invention can be performed locally, distally, or remotely from the target site.
  • the present invention also contemplates use of electrode assembly 10 integrated with imaging methods known in the art such as X-rays, computer tomography, magnetic resonance imaging, and functional magnetic resonance imaging.
  • Electrode assembly 10 may also be implemented within a drug delivery system to provide chemical stimulation utilizing a drug, pharmaceutical, or therapeutic agent.
  • the signal generator is replaced with or includes a pump and electrical contacts 10 are replaced with a drug ports.
  • the pump may be implanted below the skin of a patient and may have a port into which a hypodermic needle can be inserted through the skin to inject a quantity of a liquid, such as a drug, pharmaceutical, or therapeutic agent.
  • the liquid agent is delivered from a pump through a catheter port into a catheter.
  • the pump maybe located outside of the patient's body.
  • the catheter is positioned to deliver the liquid agent to specific infusion sites in the brain or other target site.
  • electrode assembly 10 may be combined with a drug delivery system to provide both chemical and electrical signals to target regions.
  • the present invention provides a catheter 80 having multiple lumens, wherein one of the multiple lumens houses electrode assembly 10.
  • catheter 80 is a pulmonary artery catheter, such as a Swan-Ganz type pulmonary artery catheter, wherein the multiple lumens allow for the measurement of cardiac output, pulmonary pressure, atrial pressure, and for providing an electrical signal to a target site adjacent a lumen.
  • catheter 80 comprises a thermistor lumen 31 housing a thermistor 32 to measure cardiac output; a pulmonary artery distal lumen 41 housing a sensor 42 to measure pulmonary artery pressure or pulmonary capillary wedge pressure; a proximal right atrial lumen 51 housing a sensor 52 to measure right atrial or central venous pressure; a balloon lumen 71 housing a balloon 72 to isolating the right chamber of the heart from the left chamber; and an electrode lumen 61 housing electrode assembly 10.
  • catheter 80 is delivered and implanted in a manner similar to the delivery and implantation process used in currently available pulmonary artery catheters.
  • catheter 80 is passed through an introducer up to a 20cm mark.
  • balloon 72 at the distal end of balloon lumen 71 is inflated and pressure and tracings are recorded.
  • a wedge pulmonary pressure can be obtained from the sensor of pulmonary artery distal lumen 41. This pressure indication provides the physician the necessary feedback that the distal end of catheter 80 is well positioned in the pulmonary artery.
  • the electrode assembly 10 is urged forward out from electrode lumen 61 to the walls of the pulmonary artery.
  • X- ray and fluoroscopy can be used to aid in positioning catheter 80.
  • Such a method could be used to apply an electrical signal to a target site adjacent a pulmonary nerve, such as cardiac nerves to modulate the activity thereof.
  • a method of delivering catheter 80 is only exemplary and catheter 80 is not limited by any particular method of delivery and implantation.

Abstract

A minimally invasive intraluminal electrode assembly that includes a cannulated tube and a plurality of wires disposed within the cannulated tube. Each of the plurality of wires has one of a plurality of electrical contacts on a distal end thereof. The distal portion of the plurality of wires assumes a radially constrained configuration within the cannulated tube in a retracted position and a radially extended position outward of the cannulated tube in a deployed position. The electrode assembly further comprises a spring electrode connecting the plurality of electrical contacts to collectively form a substantially circular configuration in a deployed position.

Description

INTRALUMINAL ELECTRODE ASSEMBLY
CROSS-REFERENCE TO RELATED APPLICATIONS The present application claims priority to U.S. Provisional Application No. 60/608,513, filed on September 10, 2004, which is incorporated by reference herein.
FIELD OF THE INVENTION
The present invention is directed to an expandable intraluminal electrode assembly.
BACKGROUND OF THE INVENTION
Neuromodulation, which involves delivering electrical impulses to neural target sites, has become an important therapeutic method and is an option when other forms of treatment, such as drug administration, are ineffective. Neuromodulation has revolutionized the treatment of several neurological disorders, such as movement disorders and chronic pain and has been described in U.S. Patent No. 6885,888 for treating heart contractility. Technical and mechanical limitations, however, create obstacles to the final application of such methods in patients. For example, one obstacle is in the invasive nature of neuromodulation, which requires open surgery.
As such, there is a need for further approaches for neuromodulation, particularly minimally invasive approaches.
SUMMARY OF THE INVENTION hi an embodiment, the present invention provides an intraluminal electrode assembly comprising a cannulated tube and a plurality of wires disposed in the cannulated tube. Each of the plurality of wires has one of a plurality of electrical contacts at a distal end thereof. The plurality of wirps assumes a radially constrgined configuration within the cannulated tube in a retracted position and a radially extended configuration outward of the cannulated tube in a deployed position. The electrode assembly further comprises a spring wire connecting the plurality of electrical contacts together to collectively form a substantially circular configuration in a deployed position. BRIEF DESCRIPTION OF THE DRAWINGS
The present invention will become more fully understood from the detailed description given hereinbelow and the accompanying drawings which are given by way of illustration only. It should be understood that the present invention is in no way limited to the particular arrangement or inclusion of components depicted in the accompanying drawings and wherein:
FIG. 1 depicts a perspective view of an embodiment of an intraluminal electrode assembly according to the present invention in a retracted position.
FIG. 2 depicts a perspective view of an embodiment of an intraluminal electrode assembly according to the present invention in a deployed position.
FIG. 3 depicts an end view of an embodiment of an intraluminal electrode assembly according to the present invention.
FIG. 4 depicts a pulmonary artery catheter including an embodiment of an intraluminal electrode assembly according to the present invention.
FIG. 5 illustrates a step from an exemplary method of delivering a pulmonary artery catheter including an embodiment of an intraluminal electrode assembly according to the present invention.
FIG. 6 illustrates a step after the step illustrated in FIG. 5 from an exemplary method of delivering a pulmonary artery catheter including an embodiment of an intraluminal electrode assembly according to the present invention.
DETAILED DESCRIPTION OF THE INVENTION
Referring to FIGs. 1-3, the present invention provides an electrode assembly 10 comprising a cannulated tube 20, which can be a catheter, housing a plurality of wires 30. Each of the plurality of wires 30 has one of a plurality of electrical contacts 40 at a distal end thereof. Referring specifically to FIG. 1, in a retracted position, the plurality of wires 30 assumes a radially constrained configuration within cannulated tube 20. Referring to FIG. 2, in a deployed position, the distal portion of plurality of wires 30 assumes a radially extended configuration outward of cannulated tube 20. As seen from the end view of electrode assembly 10 in FIG. 3, a spring wire 50 connects the plurality of electrical contacts 40 (depicted as electrical contacts 40a-40g) together to form a substantially circular configuration in a deployed position. Ih an embodiment, plurality of wires 30, or at least the distal portion of plurality of wires 30 having electrical contacts 40 are fabricated from a shape memory material to allow the distal portion to project concentrically out of cannulated tube 20. Of course, other mechanisms for allowing the distal portion of plurality of wires 30 having electrical contacts 40 to project radially outward from cannulated tube 20 can be employed.
Although electrode assembly 10 is not necessarily limited to any particular use, the substantially circular configuration of the distal end of deployed plurality of wires 30 allows electrode assembly 10 to be used for intraluminal purposes, such as transvascular electrical neuromodulation of a target site adjacent to a vessel. Specifically, referring to FIG. 1, electrode assembly 10 can be inserted into a vessel 60 and urged distally forward. Referring to FIG. 2, upon reaching the desired point in vessel 60, plurality of wires 30 can be deployed to project radially outward to reach and contact the walls of vessel 60. Since all the plurality of wires 30 have the same shape, the final resulting vector drives the distal portion of plurality of wires 30 out from cannulated tube 20 to contact the wall of vessel 60.
In a preferred embodiment, plurality of wires 30 comprises six to eight wires. Further preferably, each of the plurality of electrical contacts 40 of the plurality of wires 30 can be selectively activated such that select electrical contacts 40 on one segment of the arc of the distal end of the plurality of wires 30 can be activated to apply focused electrical signals on a desired side of a vessel. The selective powerability over each electrical contact 40 may be achieved by employing a system including a programmer coupled via a conductor to a telemetry antenna. The programmer is capable of sending signals via the telemetry antenna to control the electrical signal delivered to electrical contacts 40. Such a system permits the selection of various pulse output options after electrode assembly 10 is positioned using telemetry communications. The present, invention als~o contemplated radio-frequency systems to selectively power electrical contacts 40.
As will be understood by one of skill in the art, the independent powerability of electrical contacts 40 also provides a practitioner with a means of modify or steering the direction and locus of application of electrical signals to precisely target portions of the target region to achieve the desired therapy. For example, with reference to FIG. 2, electrical contact 40a may be powered to apply an electrical signal to an area adjacent thereto while the signal to electrical contact 4Oe may be substantially minimized to reduce or stop the application of an electrical signal to an area adjacent to electrical contact 4Oe. Because the locus of stimulation can be selectively adjusted and/or steered in this embodiment of electrode assembly 10, specific areas of the target region can be precisely targeted to achieve the desired therapy. Other or additional means of selectively steering the application of electrical signals may also be utilized in the present invention, such as the methods described in U.S. Patent No. 5,713,922, which is incorporated by reference herein.
Referring to FIG. 2, in a preferred embodiment, the proximal end of each of the plurality of wires 30 is in communication with rotator 70 at the proximal end of cannulated tube 20 such the distal end of the plurality of wires 30 can be rotated by similar motion of rotator 70. For example, rotator 70 could be a rotary motor or a manual dial that transfers rotational motion from rotator 70 to the distal end of the plurality of wires 30.
The present invention also provides an electrode assembly system including electrode assembly 10 and further including components useful in identifying, monitoring, or affecting a target region. For example, such a system could include a component for lesioning and temperature monitoring, and/or a component that has a fiberoptic monitor which allows telemetric intracranial monitoring capabilities, and/or a microelectrode recording component, and/or a sensing component to incorporate a feedback mechanism to assist in determining whether electrical contacts 40 should be adjusted. With respect to a sensing component, a sensor can be incorporated with the electrode assembly system according to the present invention. The sensors can be used with a closed-loop feedback system in order to automatically determine the level of electrical signal to apply to provide the desired therapy. The sensors may be implanted or positioned in or at a portion of the patient's body suitable for detecting characteristics, symptoms or attributes of the condition or disorder being treated, for example, such as electrical brain activity, cerebral blood flow, and/or vital signs or other chemical and electrical activity of the body. Sensors suitable for use in a system according to the present invention include, for example, those disclosed in U.S. Patent No. 5,711,316, which is incorporated by reference herein. In cases where the attribute of the symptom is the electrical activity of the brain, stimulating electrodes may be intermittently used to record electrical activity. Alternatively, one or more electrodes implanted or positioned within the brain may serve as a sensor or a recording electrode. When necessary, these sensing or recording electrodes may deliver stimulation therapy to the target region. The output of an external feedback sensor may communicate with a pulse generator through a telemetry down-link. Any sensing functions in accordance with the present invention can be performed locally, distally, or remotely from the target site. The present invention also contemplates use of electrode assembly 10 integrated with imaging methods known in the art such as X-rays, computer tomography, magnetic resonance imaging, and functional magnetic resonance imaging.
Electrode assembly 10 may also be implemented within a drug delivery system to provide chemical stimulation utilizing a drug, pharmaceutical, or therapeutic agent. In this embodiment, the signal generator is replaced with or includes a pump and electrical contacts 10 are replaced with a drug ports. The pump may be implanted below the skin of a patient and may have a port into which a hypodermic needle can be inserted through the skin to inject a quantity of a liquid, such as a drug, pharmaceutical, or therapeutic agent. The liquid agent is delivered from a pump through a catheter port into a catheter. Alternatively, the pump maybe located outside of the patient's body. The catheter is positioned to deliver the liquid agent to specific infusion sites in the brain or other target site. Alternatively, electrode assembly 10 may be combined with a drug delivery system to provide both chemical and electrical signals to target regions.
Referring to FIG. 4, in another embodiment, the present invention provides a catheter 80 having multiple lumens, wherein one of the multiple lumens houses electrode assembly 10. In a preferred embodiment, catheter 80 is a pulmonary artery catheter, such as a Swan-Ganz type pulmonary artery catheter, wherein the multiple lumens allow for the measurement of cardiac output, pulmonary pressure, atrial pressure, and for providing an electrical signal to a target site adjacent a lumen. Specifically, in an embodiment catheter 80 comprises a thermistor lumen 31 housing a thermistor 32 to measure cardiac output; a pulmonary artery distal lumen 41 housing a sensor 42 to measure pulmonary artery pressure or pulmonary capillary wedge pressure; a proximal right atrial lumen 51 housing a sensor 52 to measure right atrial or central venous pressure; a balloon lumen 71 housing a balloon 72 to isolating the right chamber of the heart from the left chamber; and an electrode lumen 61 housing electrode assembly 10.
In an exemplary method of using catheter 80 in a pulmonary artery, catheter 80 is delivered and implanted in a manner similar to the delivery and implantation process used in currently available pulmonary artery catheters. Referring to FIG. 5 and FIG. 6, after venous access, catheter 80 is passed through an introducer up to a 20cm mark. Then,, balloon 72 at the distal end of balloon lumen 71 is inflated and pressure and tracings are recorded. As soon as catheter 80 is advanced to the point where'the inflated balloon 72 occludes the pulmonary artery, a wedge pulmonary pressure can be obtained from the sensor of pulmonary artery distal lumen 41. This pressure indication provides the physician the necessary feedback that the distal end of catheter 80 is well positioned in the pulmonary artery. Once adequate positioning is achieved, the electrode assembly 10 is urged forward out from electrode lumen 61 to the walls of the pulmonary artery. X- ray and fluoroscopy can be used to aid in positioning catheter 80. Such a method could be used to apply an electrical signal to a target site adjacent a pulmonary nerve, such as cardiac nerves to modulate the activity thereof. Of course, such a method of delivering catheter 80 is only exemplary and catheter 80 is not limited by any particular method of delivery and implantation.
The foregoing description has been set forth merely to illustrate the invention and are not intended as being limiting. Each of the disclosed aspects and embodiments of the present invention may be considered individually or in combination with other aspects, embodiments, and variations of the invention. In addition, unless otherwise specified, none of the steps of the methods of the present invention are confined to any particular order of performance. Further, although electrode assembly 10 is occasionally described with respect to neuromodulation, electrode assembly 10 is not limited to this particular use. Modifications of the disclosed embodiments incorporating the spirit and substance of the invention may occur to persons skilled in the art and such modifications are within the scope of the present invention. For example, although catheter 80 is described as have a balloon lumen 71 with a balloon 72 at the distal end thereof, other embodiments can include catheter 80 having multiple lumens without a balloon. Furthermore, all references cited herein are incorporated by reference in their entirety.

Claims

We claim:
1. An electrode assembly comprising: a cannulated tube; a plurality of wires disposed within the cannulated tube, each of the plurality of wires having one of a plurality of electrical contacts on a distal end thereof, the distal portion of the plurality of wires assuming a radially constrained configuration within the cannulated tube in a retracted position and a radially extended position outward of the cannulated tube in a deployed position; and a spring electrode connecting the plurality of electrical contacts to collectively form a substantially circular configuration in a deployed position.
2 The electrode assembly of claim 1 , wherein the plurality of wires comprises six to eight wires.
3. The electrode assembly of claim 1, wherein the plurality of wires is fabricated from a shape memory material.
4. The electrical assembly of claim 1 , wherein a proximal end of the plurality of wires is connected to a rotator at a proximal end of the canulated tube to transfer rotational motion from the rotator to the plurality of wires.
5. The electrical assembly of claim 1, wherein each of the electrical contacts is selectively powerable.
6. A catheter comprising multiple lumens, one of the multiple lumens housing the electrode assembly of claim 1.
7. The catheter of claim 6, wherein the multiple lumens comprise: a thermistor lumen housing a thermistor to measure cardiac output; a pulmonary artery distal lumen housing a sensor to measure pulmonary artery pressure or pulmonary capillary wedge pressure; a proximal right atrial lumen for housing a sensor to measure right atrial or central venous pressure; a balloon lumen housing a balloon to isolating the right chamber of the heart from the left chamber; and an electrode lumen housing the electrode assembly of claim 1.
PCT/US2005/032765 2004-09-10 2005-09-12 Intraluminal electrode assembly WO2006031899A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05797614A EP1804902A4 (en) 2004-09-10 2005-09-12 Intraluminal electrode assembly

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60851304P 2004-09-10 2004-09-10
US60/608,513 2004-09-10

Publications (2)

Publication Number Publication Date
WO2006031899A2 true WO2006031899A2 (en) 2006-03-23
WO2006031899A3 WO2006031899A3 (en) 2006-12-21

Family

ID=36060680

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/032769 WO2006031902A2 (en) 2004-09-10 2005-09-12 Methods and systems of achieving hemodynamic control through neuromodulation
PCT/US2005/032765 WO2006031899A2 (en) 2004-09-10 2005-09-12 Intraluminal electrode assembly

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2005/032769 WO2006031902A2 (en) 2004-09-10 2005-09-12 Methods and systems of achieving hemodynamic control through neuromodulation

Country Status (3)

Country Link
US (2) US7865237B2 (en)
EP (2) EP1804907A2 (en)
WO (2) WO2006031902A2 (en)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7647115B2 (en) 2002-04-08 2010-01-12 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US7941227B2 (en) 2008-09-03 2011-05-10 Boston Scientific Neuromodulation Corporation Implantable electric stimulation system and methods of making and using
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
JP2013236662A (en) * 2012-05-11 2013-11-28 Olympus Corp Neurostimulation electrode and neurostimulation system
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8771252B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US9192715B2 (en) 2002-04-08 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal nerve blocking
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9950161B2 (en) 2004-10-05 2018-04-24 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10034708B2 (en) 2002-04-08 2018-07-31 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for thermally-induced renal neuromodulation
US10039596B2 (en) 2002-04-08 2018-08-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatus for renal neuromodulation via an intra-to-extravascular approach
US10080864B2 (en) 2012-10-19 2018-09-25 Medtronic Ardian Luxembourg S.A.R.L. Packaging for catheter treatment devices and associated devices, systems, and methods
US10124195B2 (en) 2002-04-08 2018-11-13 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermally-induced renal neuromodulation
US10130792B2 (en) 2002-04-08 2018-11-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation using neuromodulatory agents or drugs
US10179020B2 (en) 2010-10-25 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems and methods for evaluation and feedback of neuromodulation treatment
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10537385B2 (en) 2008-12-31 2020-01-21 Medtronic Ardian Luxembourg S.A.R.L. Intravascular, thermally-induced renal neuromodulation for treatment of polycystic ovary syndrome or infertility
US10874455B2 (en) 2012-03-08 2020-12-29 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
US11338140B2 (en) 2012-03-08 2022-05-24 Medtronic Ardian Luxembourg S.A.R.L. Monitoring of neuromodulation using biomarkers

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
US7689277B2 (en) * 2002-03-22 2010-03-30 Leptos Biomedical, Inc. Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
US7775087B2 (en) * 2004-03-16 2010-08-17 Northwestern University Microchannel forming method and nanotipped dispensing device having a microchannel
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US7962208B2 (en) 2005-04-25 2011-06-14 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US20110118773A1 (en) * 2005-07-25 2011-05-19 Rainbow Medical Ltd. Elliptical device for treating afterload
US20070021786A1 (en) * 2005-07-25 2007-01-25 Cyberonics, Inc. Selective nerve stimulation for the treatment of angina pectoris
US20070027497A1 (en) * 2005-07-27 2007-02-01 Cyberonics, Inc. Nerve stimulation for treatment of syncope
US8660647B2 (en) 2005-07-28 2014-02-25 Cyberonics, Inc. Stimulating cranial nerve to treat pulmonary disorder
US7706874B2 (en) 2005-07-28 2010-04-27 Cyberonics, Inc. Stimulating cranial nerve to treat disorders associated with the thyroid gland
US20070092591A1 (en) * 2005-10-24 2007-04-26 Cyberonics, Inc. Vacuum mandrel for use in fabricating an implantable electrode
US8509914B2 (en) * 2005-10-28 2013-08-13 Cyberonics, Inc. Insert for implantable electrode
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US7467016B2 (en) * 2006-01-27 2008-12-16 Cyberonics, Inc. Multipolar stimulation electrode with mating structures for gripping targeted tissue
US8615309B2 (en) 2006-03-29 2013-12-24 Catholic Healthcare West Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US8180462B2 (en) * 2006-04-18 2012-05-15 Cyberonics, Inc. Heat dissipation for a lead assembly
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US10499937B2 (en) 2006-05-19 2019-12-10 Recor Medical, Inc. Ablation device with optimized input power profile and method of using the same
US8478420B2 (en) * 2006-07-12 2013-07-02 Cyberonics, Inc. Implantable medical device charge balance assessment
US20080027524A1 (en) * 2006-07-26 2008-01-31 Maschino Steven E Multi-electrode assembly for an implantable medical device
US20080071315A1 (en) * 2006-08-31 2008-03-20 Tamara Colette Baynham Integrated catheter and pulse generator systems and methods
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
WO2008070189A2 (en) 2006-12-06 2008-06-12 The Cleveland Clinic Foundation Method and system for treating acute heart failure by neuromodulation
US7974707B2 (en) * 2007-01-26 2011-07-05 Cyberonics, Inc. Electrode assembly with fibers for a medical device
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US7818069B2 (en) * 2007-07-27 2010-10-19 Cyberonics, Inc. Ribbon electrode
US8942798B2 (en) 2007-10-26 2015-01-27 Cyberonics, Inc. Alternative operation mode for an implantable medical device based upon lead condition
US8868203B2 (en) 2007-10-26 2014-10-21 Cyberonics, Inc. Dynamic lead condition detection for an implantable medical device
JP5116856B2 (en) 2007-12-28 2013-01-09 シーブイアールエックス，インコーポレイテッド Measurement of patient physiological parameters
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US7925352B2 (en) 2008-03-27 2011-04-12 Synecor Llc System and method for transvascularly stimulating contents of the carotid sheath
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
US8473062B2 (en) * 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
US8401652B2 (en) 2008-06-16 2013-03-19 Cvrx, Inc. Devices and methods for treatment of heart failure and associated conditions
US8321024B2 (en) 2008-06-16 2012-11-27 Cvrx, Inc. Devices and methods for treatment of heart failure and associated conditions
US8326430B2 (en) 2008-06-16 2012-12-04 Cvrx, Inc. Devices and methods for treatment of heart failure and associated conditions
US8244352B2 (en) 2008-06-19 2012-08-14 Cardiac Pacemakers, Inc. Pacing catheter releasing conductive liquid
JP5282142B2 (en) * 2008-06-19 2013-09-04 カーディアック ペースメイカーズ， インコーポレイテッド Pacing catheter with expandable distal end
US8639357B2 (en) * 2008-06-19 2014-01-28 Cardiac Pacemakers, Inc. Pacing catheter with stent electrode
US20090318749A1 (en) * 2008-06-19 2009-12-24 Craig Stolen Method and apparatus for pacing and intermittent ischemia
US9037235B2 (en) 2008-06-19 2015-05-19 Cardiac Pacemakers, Inc. Pacing catheter with expandable distal end
US20090318984A1 (en) * 2008-06-19 2009-12-24 Mokelke Eric A External pacemaker with automatic cardioprotective pacing protocol
US9409012B2 (en) * 2008-06-19 2016-08-09 Cardiac Pacemakers, Inc. Pacemaker integrated with vascular intervention catheter
US20090318994A1 (en) * 2008-06-19 2009-12-24 Tracee Eidenschink Transvascular balloon catheter with pacing electrodes on shaft
US8457738B2 (en) * 2008-06-19 2013-06-04 Cardiac Pacemakers, Inc. Pacing catheter for access to multiple vessels
US20100056858A1 (en) * 2008-09-02 2010-03-04 Mokelke Eric A Pacing system for use during cardiac catheterization or surgery
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
WO2010080886A1 (en) 2009-01-09 2010-07-15 Recor Medical, Inc. Methods and apparatus for treatment of mitral valve in insufficiency
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US20100191304A1 (en) 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
US9149320B2 (en) * 2009-02-02 2015-10-06 Medtronic Cryocath Lp Isolation of pulmonary vein
WO2011017049A1 (en) 2009-07-27 2011-02-10 Cardiac Pacemakers, Inc. Medical device for treating heart failure through blood volume redistribution
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US8478428B2 (en) 2010-04-23 2013-07-02 Cyberonics, Inc. Helical electrode for nerve stimulation
EP2701795B1 (en) 2011-04-28 2020-12-09 Interventional Autonomics Corporation Neuromodulation systems for treating acute heart failure syndromes
US9446240B2 (en) 2011-07-11 2016-09-20 Interventional Autonomics Corporation System and method for neuromodulation
US20130072995A1 (en) 2011-07-11 2013-03-21 Terrance Ransbury Catheter system for acute neuromodulation
CA2878396A1 (en) 2011-07-11 2013-02-28 Interventional Autonomics Corporation System and method for neuromodulation
SG11201402610QA (en) 2011-12-09 2014-10-30 Metavention Inc Therapeutic neuromodulation of the hepatic system
US9126055B2 (en) 2012-04-20 2015-09-08 Cardiac Science Corporation AED faster time to shock method and device
US8612022B1 (en) 2012-09-13 2013-12-17 Invatec S.P.A. Neuromodulation catheters and associated systems and methods
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
WO2015148445A1 (en) 2014-03-24 2015-10-01 Old Dominion University Research Foundation Expandable catheter devices electrode array
AU2015264121B2 (en) 2014-05-22 2020-05-28 CARDIONOMIC, Inc. Catheter and catheter system for electrical neuromodulation
AU2015315658B2 (en) 2014-09-08 2019-05-23 CARDIONOMIC, Inc. Catheter and electrode systems for electrical neuromodulation
AU2015315570B2 (en) 2014-09-08 2020-05-14 CARDIONOMIC, Inc. Methods for electrical neuromodulation of the heart
EP3610917A1 (en) 2015-01-05 2020-02-19 Cardionomic, Inc. Cardiac modulation facilitation methods and systems
US10376308B2 (en) 2015-02-05 2019-08-13 Axon Therapies, Inc. Devices and methods for treatment of heart failure by splanchnic nerve ablation
US10207110B1 (en) 2015-10-13 2019-02-19 Axon Therapies, Inc. Devices and methods for treatment of heart failure via electrical modulation of a splanchnic nerve
AU2017229496B2 (en) 2016-03-09 2022-03-31 CARDIONOMIC, Inc. Cardiac contractility neurostimulation systems and methods
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
CN114711957A (en) 2016-07-29 2022-07-08 阿克松疗法公司 Devices, systems, and methods for treating heart failure through cardiac nerve ablation
EP3664703A4 (en) 2017-09-13 2021-05-12 Cardionomic, Inc. Neurostimulation systems and methods for affecting cardiac contractility
US10561461B2 (en) 2017-12-17 2020-02-18 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
CN111886043B (en) 2018-01-26 2024-03-29 阿克松疗法公司 Method and apparatus for intravascular ablation of visceral nerves
JP2021535776A (en) 2018-08-13 2021-12-23 カーディオノミック，インク． Systems and methods that act on systole and / or relaxation
BR112021021976A2 (en) * 2019-05-02 2022-01-11 Closed Loop Medicine Ltd Methods and systems for delivering personalized medicine to a patient
JP2022531658A (en) 2019-05-06 2022-07-08 カーディオノミック，インク． Systems and methods for noise reduction of physiological signals during electrical neural regulation
EP4241836A3 (en) 2019-06-20 2023-11-29 Axon Therapies, Inc. Devices for endovascular ablation of a splanchnic nerve
EP4209191A1 (en) 2020-01-17 2023-07-12 Axon Therapies, Inc. Catheter and computer for calculation of accumulated volume of liquid delivered into a patient

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT385894B (en) 1985-10-04 1988-05-25 Basem Dr Nashef TUBULAR PROBE
US4718423A (en) * 1986-10-17 1988-01-12 Spectramed, Inc. Multiple-function cardiovascular catheter system with very high lumenal efficiency and no crossovers
US4776249A (en) * 1986-10-29 1988-10-11 Barclay Randel L Resharpenable rotary shearing apparatus
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5318592A (en) 1991-09-12 1994-06-07 BIOTRONIK, Mess- und Therapiegerate GmbH & Co., Ingenieurburo Berlin Cardiac therapy system
SE9203733D0 (en) * 1992-12-11 1992-12-11 Siemens Elema Ab defibrillation
US5458626A (en) * 1993-12-27 1995-10-17 Krause; Horst E. Method of electrical nerve stimulation for acceleration of tissue healing
US5571159A (en) * 1994-04-04 1996-11-05 Alt; Eckhard Temporary atrial defibrillation catheter and method
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US6006134A (en) * 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6058331A (en) * 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6292695B1 (en) * 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US7805188B2 (en) 2000-03-24 2010-09-28 Micor, Inc. Anesthesia conduction catheter for delivery of electrical stimulus
US7616997B2 (en) * 2000-09-27 2009-11-10 Kieval Robert S Devices and methods for cardiovascular reflex control via coupled electrodes
US8086314B1 (en) * 2000-09-27 2011-12-27 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US20030004549A1 (en) * 2000-10-26 2003-01-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
US8417334B2 (en) * 2000-10-26 2013-04-09 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions
US6564096B2 (en) * 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
EP1429839A2 (en) * 2001-08-28 2004-06-23 Medtronic, Inc. Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation
US7778711B2 (en) * 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Reduction of heart rate variability by parasympathetic stimulation
US7239912B2 (en) * 2002-03-22 2007-07-03 Leptos Biomedical, Inc. Electric modulation of sympathetic nervous system
US7551964B2 (en) * 2002-03-22 2009-06-23 Leptos Biomedical, Inc. Splanchnic nerve stimulation for treatment of obesity
US7123959B2 (en) * 2002-03-25 2006-10-17 Cardiac Pacemakers, Inc. Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation
US7162303B2 (en) * 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
EP1682196A2 (en) * 2003-11-10 2006-07-26 Angiotech International Ag Medical implants and anti-scarring agents
US8024050B2 (en) 2003-12-24 2011-09-20 Cardiac Pacemakers, Inc. Lead for stimulating the baroreceptors in the pulmonary artery
US8175705B2 (en) * 2004-10-12 2012-05-08 Cardiac Pacemakers, Inc. System and method for sustained baroreflex stimulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of EP1804902A4 *

Cited By (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9956410B2 (en) 2002-04-08 2018-05-01 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US10179027B2 (en) 2002-04-08 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable baskets for renal neuromodulation and associated systems and methods
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US11033328B2 (en) 2002-04-08 2021-06-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9895195B2 (en) 2002-04-08 2018-02-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8131372B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Renal nerve stimulation method for treatment of patients
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8150518B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US10850091B2 (en) 2002-04-08 2020-12-01 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8551069B2 (en) 2002-04-08 2013-10-08 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for treating contrast nephropathy
US9907611B2 (en) 2002-04-08 2018-03-06 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8771252B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US9072527B2 (en) 2002-04-08 2015-07-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatuses and methods for renal neuromodulation
US9192715B2 (en) 2002-04-08 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal nerve blocking
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9675413B2 (en) 2002-04-08 2017-06-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9731132B2 (en) 2002-04-08 2017-08-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation
US9743983B2 (en) 2002-04-08 2017-08-29 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9757193B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatus for renal neuromodulation
US9757192B2 (en) 2002-04-08 2017-09-12 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of patients
US9814873B2 (en) 2002-04-08 2017-11-14 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US9827040B2 (en) 2002-04-08 2017-11-28 Medtronic Adrian Luxembourg S.a.r.l. Methods and apparatus for intravascularly-induced neuromodulation
US9827041B2 (en) 2002-04-08 2017-11-28 Medtronic Ardian Luxembourg S.A.R.L. Balloon catheter apparatuses for renal denervation
US10441356B2 (en) 2002-04-08 2019-10-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for renal neuromodulation via neuromodulatory agents
US10420606B2 (en) 2002-04-08 2019-09-24 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US7647115B2 (en) 2002-04-08 2010-01-12 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US9968611B2 (en) 2002-04-08 2018-05-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US10376311B2 (en) 2002-04-08 2019-08-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravascularly-induced neuromodulation
US10034708B2 (en) 2002-04-08 2018-07-31 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for thermally-induced renal neuromodulation
US10039596B2 (en) 2002-04-08 2018-08-07 Medtronic Ardian Luxembourg S.A.R.L. Apparatus for renal neuromodulation via an intra-to-extravascular approach
US10376516B2 (en) 2002-04-08 2019-08-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for renal nerve blocking
US10105180B2 (en) 2002-04-08 2018-10-23 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravascularly-induced neuromodulation
US10111707B2 (en) 2002-04-08 2018-10-30 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation for treatment of human patients
US10124195B2 (en) 2002-04-08 2018-11-13 Medtronic Ardian Luxembourg S.A.R.L. Methods for thermally-induced renal neuromodulation
US10130792B2 (en) 2002-04-08 2018-11-20 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation using neuromodulatory agents or drugs
US10179235B2 (en) 2002-04-08 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
US10376312B2 (en) 2002-04-08 2019-08-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for monopolar renal neuromodulation
US10179028B2 (en) 2002-04-08 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating patients via renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US10293190B2 (en) 2002-04-08 2019-05-21 Medtronic Ardian Luxembourg S.A.R.L. Thermally-induced renal neuromodulation and associated systems and methods
US10272246B2 (en) 2002-04-08 2019-04-30 Medtronic Adrian Luxembourg S.a.r.l Methods for extravascular renal neuromodulation
US10245429B2 (en) 2002-04-08 2019-04-02 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9950161B2 (en) 2004-10-05 2018-04-24 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
US10537734B2 (en) 2004-10-05 2020-01-21 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for multi-vessel renal neuromodulation
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US7941227B2 (en) 2008-09-03 2011-05-10 Boston Scientific Neuromodulation Corporation Implantable electric stimulation system and methods of making and using
US10561460B2 (en) 2008-12-31 2020-02-18 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation systems and methods for treatment of sexual dysfunction
US10537385B2 (en) 2008-12-31 2020-01-21 Medtronic Ardian Luxembourg S.A.R.L. Intravascular, thermally-induced renal neuromodulation for treatment of polycystic ovary syndrome or infertility
US10179020B2 (en) 2010-10-25 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems and methods for evaluation and feedback of neuromodulation treatment
US10874455B2 (en) 2012-03-08 2020-12-29 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
US11338140B2 (en) 2012-03-08 2022-05-24 Medtronic Ardian Luxembourg S.A.R.L. Monitoring of neuromodulation using biomarkers
JP2013236662A (en) * 2012-05-11 2013-11-28 Olympus Corp Neurostimulation electrode and neurostimulation system
US10080864B2 (en) 2012-10-19 2018-09-25 Medtronic Ardian Luxembourg S.A.R.L. Packaging for catheter treatment devices and associated devices, systems, and methods
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation

Also Published As

Publication number Publication date
US20060058597A1 (en) 2006-03-16
WO2006031902A2 (en) 2006-03-23
WO2006031902A9 (en) 2006-05-11
WO2006031899A3 (en) 2006-12-21
US7865237B2 (en) 2011-01-04
WO2006031902A3 (en) 2006-11-30
US7532938B2 (en) 2009-05-12
EP1804902A2 (en) 2007-07-11
EP1804907A2 (en) 2007-07-11
EP1804902A4 (en) 2008-04-16
US20060100667A1 (en) 2006-05-11

Similar Documents

Publication Publication Date Title
US7532938B2 (en) Intraluminal electrode assembly
US20210113266A1 (en) Systems, methods, and devices for monitoring and treatment of tissues within and/or through a lumen wall
EP2076307B1 (en) Implantable apparatus for endolymphatic drug delivery
EP1181947B1 (en) Spinal cord stimulation leads
US6845267B2 (en) Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US7254443B2 (en) Implantable medical device including a hermetic connector block extension
US6510348B2 (en) Perfusion lead and method of use
US6832115B2 (en) Catheter leads for the intrathecal space and method of use
US8417345B2 (en) Corpus callosum neuromodulation assembly
US20060025841A1 (en) Thalamic stimulation device
JP4500314B2 (en) Fixing medical leads
US20130023975A1 (en) Intravascular medical device with advancable electrode
US20080108904A1 (en) Implant for securing a sensor in a vessel
JP2006501894A (en) Active fluid delivery catheter
US7200446B2 (en) Catheter leads for the intrathecal space and method of use
JP2008521566A (en) Method and system for providing therapy in the pericardial space
CN111163834A (en) Device for preventing, reducing and/or treating cognitive impairment
US11344210B2 (en) Delivery catheter for implantable medical device
US10687794B2 (en) Delivery catheter for implantable medical device

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005797614

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2005797614

Country of ref document: EP