WO2006039675A3 - Apparatus and method for nanomanipulation of biomolecules and living cells - Google Patents

Apparatus and method for nanomanipulation of biomolecules and living cells Download PDF

Info

Publication number
WO2006039675A3
WO2006039675A3 PCT/US2005/035551 US2005035551W WO2006039675A3 WO 2006039675 A3 WO2006039675 A3 WO 2006039675A3 US 2005035551 W US2005035551 W US 2005035551W WO 2006039675 A3 WO2006039675 A3 WO 2006039675A3
Authority
WO
WIPO (PCT)
Prior art keywords
electromagnetic
core
particles
biomolecules
living cells
Prior art date
Application number
PCT/US2005/035551
Other languages
French (fr)
Other versions
WO2006039675A2 (en
Inventor
Donald E Ingber
Benjamin D Matthews
David A Lavan
Darryl Overby
Original Assignee
Childrens Medical Center
Donald E Ingber
Benjamin D Matthews
David A Lavan
Darryl Overby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center, Donald E Ingber, Benjamin D Matthews, David A Lavan, Darryl Overby filed Critical Childrens Medical Center
Publication of WO2006039675A2 publication Critical patent/WO2006039675A2/en
Publication of WO2006039675A3 publication Critical patent/WO2006039675A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/002—Magnetotherapy in combination with another treatment

Abstract

The present invention relates to an electromagnetic needle for magnetically manipulating microscopic particles and a method of making the same, and more particularly, to a method for nanomanipulating biomolecules and/or living cells using the electromagnetic needle of the present invention. The temperature-controlled electromagnetic microneedle includes an electromagnetic core having a magnetic probe tip. A wire coil is wound around at least a portion of the core and electrically isolated from the core. A thermo-regulating water jacket having a first and second end and enveloping the electromagnetic core and wire coil allows the probe tip to extend from the first end. Magnetically responsive particles upon which a biologically active substance is absorbed are administered to a subject. A catheter having a magnet attached thereto is inserted into the body of the subject. The magnet guides the particles to a site to be treated with the biologically active substance.
PCT/US2005/035551 2004-10-01 2005-10-03 Apparatus and method for nanomanipulation of biomolecules and living cells WO2006039675A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61499904P 2004-10-01 2004-10-01
US60/614,999 2004-10-01

Publications (2)

Publication Number Publication Date
WO2006039675A2 WO2006039675A2 (en) 2006-04-13
WO2006039675A3 true WO2006039675A3 (en) 2006-06-29

Family

ID=36143152

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/035551 WO2006039675A2 (en) 2004-10-01 2005-10-03 Apparatus and method for nanomanipulation of biomolecules and living cells

Country Status (1)

Country Link
WO (1) WO2006039675A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694103B2 (en) 2003-04-16 2017-07-04 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
US7635734B2 (en) 2004-02-17 2009-12-22 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
US9028829B2 (en) 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US8562505B2 (en) 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US20090216320A1 (en) * 2006-04-21 2009-08-27 The Children's Hospital Of Philadelphia Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof
WO2008156904A2 (en) * 2007-04-09 2008-12-24 Children's Medical Center Corporation Systems and methods for nanomagnetic actuation of molecular cell signaling
DE102009004086A1 (en) * 2009-01-05 2010-07-22 Gottfried Wilhelm Leibniz Universität Hannover Electromagnetic microsystem for manipulating magnetic micro- or nanobeads
CN103432688A (en) * 2013-08-24 2013-12-11 仇活连 Reinforced electromagnetic therapeutic apparatus with superimposed magnetic fields
CN113143843B (en) * 2021-03-15 2023-11-28 上海交通大学 Medical nanoparticle fixed-point treatment device and manufacturing method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030083646A1 (en) * 2000-12-22 2003-05-01 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6603994B2 (en) * 2000-12-28 2003-08-05 Scimed Life Systems, Inc. Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance
US6626819B2 (en) * 2001-01-12 2003-09-30 Scimed Life Systems, Inc. Permanent magnetic and electromagnetic apparatus for embolizing an aneurysm with magnetically controllable embolic and method
US20030187320A1 (en) * 2002-03-29 2003-10-02 Toby Freyman Magnetically enhanced injection catheter
US6673104B2 (en) * 2001-03-15 2004-01-06 Scimed Life Systems, Inc. Magnetic stent
US6692490B1 (en) * 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
US20040143213A1 (en) * 2002-11-12 2004-07-22 Collegium Pharmaceutical, Inc. Inertial drug delivery system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692490B1 (en) * 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
US20030083646A1 (en) * 2000-12-22 2003-05-01 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6603994B2 (en) * 2000-12-28 2003-08-05 Scimed Life Systems, Inc. Apparatus and method for internally inducing a magnetic field in an aneurysm to embolize aneurysm with magnetically-controllable substance
US6626819B2 (en) * 2001-01-12 2003-09-30 Scimed Life Systems, Inc. Permanent magnetic and electromagnetic apparatus for embolizing an aneurysm with magnetically controllable embolic and method
US6673104B2 (en) * 2001-03-15 2004-01-06 Scimed Life Systems, Inc. Magnetic stent
US20030187320A1 (en) * 2002-03-29 2003-10-02 Toby Freyman Magnetically enhanced injection catheter
US20040143213A1 (en) * 2002-11-12 2004-07-22 Collegium Pharmaceutical, Inc. Inertial drug delivery system

Also Published As

Publication number Publication date
WO2006039675A2 (en) 2006-04-13

Similar Documents

Publication Publication Date Title
WO2006039675A3 (en) Apparatus and method for nanomanipulation of biomolecules and living cells
GB2441489A (en) Stylet apparatuses and methods of manufacture
EP2401024B1 (en) Devices, systems and methods for magnetic-assisted therapeutic agent delivery
US10188731B2 (en) Methods for killing cancer cells and cellular imaging using magneto-electric nano-particles and external magnetic field
EP2490764B1 (en) Catheter for electromagnetic thrombus treatment and method of manufacturing
DE102008018882A1 (en) System and method for integrating electromagnetic microsensors in guidewires
JP2000501319A (en) Improved skin transmitted electromagnetic energy transfer
EP2517752B1 (en) Magnet body and drug delivery control device using magnet body
EP2119392A3 (en) Device, system and method for magnetically maneuvering an in vivo device
US9750952B2 (en) Magnetic instrument for the homing of therapeutic cells and the elimination of excess therapeutic cells
EP0320623A1 (en) Device for determining the position of a catheter or a probe inside a living organ
CN111616802A (en) Superfine magnetic control flexible robot based on high molecular polymer flexible microtubes
CN201085658Y (en) Injection trocar
JP4742356B2 (en) Embedded electrode device and electrode embedded device
Hoebel Electrode-cannulas for electrical or chemical treatment of multiple brain sites
CA2655515A1 (en) Temperature sensing within a patient during mr imaging
Zhang et al. Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery
US20190111136A1 (en) System for achieving high-specificity killing of targeted cells and method thereof using magneto-electric nano-particles
US8554320B2 (en) Medical implantable lead
CN117814910A (en) Tracking sensor
CN2770689Y (en) Special particle implantation device for endoscope
CN215135985U (en) Magnetic guiding device
US20200222709A1 (en) Adjustable focus magnetic stimulation coil
Latulippe et al. Seeking optimal magnetic core shapes for strong gradient generation in dipole field navigation
JP2023090411A (en) guide wire

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase

Ref document number: 05811966

Country of ref document: EP

Kind code of ref document: A2